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Cai Zhengdong

Jhih-Rong Lin, Ying Cai, Quanwei Zhang, Wen Zhang, Ruben Nogales, Zhengdong Zhang
Schizophrenia is a severe mental disorder with a large genetic component. Recent genome-wide association studies (GWAS) have identified many schizophrenia-associated common variants. For most of the reported associations, however, the underlying biological mechanisms are not clear. The critical first step for their elucidation is to identify the most likely disease genes as the source of the association signals. Here, we describe a general computational framework of post-GWAS analysis for complex disease gene prioritization...
October 17, 2016: Genetics
Tao Zhang, Suoyuan Li, Jingjie Li, Fei Yin, Yingqi Hua, Zhouying Wang, Binhui Lin, Hongsheng Wang, Dongqing Zou, Zifei Zhou, Jing Xu, Chengqing Yi, Zhengdong Cai
Signal transducer and activator of transcription 3 (STAT3) has important roles in cancer aggressiveness and has been confirmed as an attractive target for cancer therapy. In this study, we used a dual-luciferase assay to identify that pectolinarigenin inhibited STAT3 activity. Further studies showed pectolinarigenin inhibited constitutive and interleukin-6-induced STAT3 signaling, diminished the accumulation of STAT3 in the nucleus and blocked STAT3 DNA-binding activity in osteosarcoma cells. Mechanism investigations indicated that pectolinarigenin disturbed the STAT3/DNA methyltransferase 1/HDAC1 histone deacetylase 1 complex formation in the promoter region of SHP-1, which reversely mediates STAT3 signaling, leading to the upregulation of SHP-1 expression in osteosarcoma...
October 13, 2016: Cell Death & Disease
Dongqing Zuo, Zifei Zhou, Hongsheng Wang, Tao Zhang, Jie Zang, Fei Yin, Wei Sun, Jiepeng Chen, Lili Duan, Jing Xu, Zhuoying Wang, Chongren Wang, Binhui Lin, Zeze Fu, Yuxin Liao, Suoyuan Li, Mengxiong Sun, Yingqi Hua, Longpo Zheng, Zhengdong Cai
Osteosarcoma (OS) is the most frequent primary malignant bone tumour. Alternol, a novel compound purified from microbial fermentation products exerts anti-tumour effects across several cancer types. The effect of alternol on human OS remains to be elucidated. We first evaluated the anti-tumour effect of alternol in several human OS cell lines in vitro and investigated its underlying mechanism. Alternol inhibited OS cell proliferation, migration and induced caspase-dependent apoptosis, G2/M cell cycle arrest in a dose and time-dependent manner...
September 14, 2016: Journal of Cellular and Molecular Medicine
Zhuoying Wang, Chongren Wang, Zifei Zhou, Mengxiong Sun, Chenghao Zhou, Jian Chen, Fei Yin, Hongsheng Wang, Binhui Lin, Dongqing Zuo, Suoyuan Li, Lijin Feng, Zhenfeng Duan, Zhengdong Cai, Yingqi Hua
CD151, a tetraspanin family protein involved in cell-cell and cell-extracellular matrix interaction, is differentially expressed in osteosarcoma cell membranes. Thus, this study aimed to investigate the role of CD151 in osteosarcoma metastasis. We analyzed CD151 expression in patient tissue samples using immunohistochemistry. CD151 expression was also silenced with shRNA in osteosarcoma cells of high metastatic potential, and cell adhesion, migration and invasion were evaluated in vitro and pulmonary metastasis was investigated in vivo...
August 19, 2016: Oncotarget
Ruben Nogales-Cadenas, Ying Cai, Jhih-Rong Lin, Quanwei Zhang, Wen Zhang, Cristina Montagna, Zhengdong D Zhang
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. Numerous studies have shown that miRNAs are not only key regulators in important cellular processes but are also drivers in the development of many diseases, especially cancer. Estrogen receptor positive luminal B is the second most common but the least studied subtype of breast cancer. Only a few studies have examined the expression profiles of miRNAs in luminal B breast cancer, and their regulatory roles in cancer progression have yet to be investigated...
2016: Breast Cancer Research: BCR
Ning Han, Zengchun Li, Zhengdong Cai, Zuoqin Yan, Yingqi Hua, Chong Xu
P-glycoprotein (P-gp) plays a role in steroid-induced osteonecrosis of the femoral head (ONFH), but the underlying mechanism remains unknown. We hypothesized that P-gp overexpression can prevent ONFH by regulating bone marrow-derived multipotent stromal cell (BMSC) adipogenesis and osteogenesis. BMSCs from Sprague-Dawley rats were transfected with green fluorescent protein (GFP) or the multidrug resistance gene 1 (MDR1) encoding GFP and P-gp. Dexamethasone was used to induce BMSC differentiation. Adipogenesis was determined by measuring peroxisome proliferator-activated receptor (PPAR-γ) expression and the triglyceride level...
July 11, 2016: Journal of Cellular and Molecular Medicine
Wei Sun, Xiaojun Ma, Jiakang Shen, Fei Yin, Chongren Wang, Zhengdong Cai
In this study, gene expression data of osteosarcoma (OSA) were analyzed to identify metastasis-related biological pathways. Four gene expression data sets (GSE21257, GSE9508, GSE49003 and GSE66673) were downloaded from Gene Expression Omnibus (GEO). An analysis of differentially expressed genes (DEGs) was performed using the Significance Analysis of Microarray (SAM) method. Gene expression levels were converted into scores of pathways by the Functional Analysis of Individual Microarray Expression (FAIME) algorithm and the differentially expressed pathways (DEPs) were then disclosed by a t-test...
August 2016: International Journal of Molecular Medicine
Dong Fu, Yiqiong Zhao, Jiakang Shen, Zhengdong Cai, Yingqi Hua
The purpose of this study was to compare and evaluate the event of VTE (Venous Thromboembolism Event) after total artificial joint replacement between two groups diagnosed with either musculoskeletal tumors or osteoarthritis (OA) of the knee. From 2004 to 2014, a total of 1,402 patients (308 in tumor group, 1,094 in OA group) were involved in this study. The rate of asymptomatic DVT (Deep vein thrombosis) was significantly higher in tumor group when compared with OA group. Though both the incidence of symptomatic DVT and PE (Pulmonary embolism) were slightly higher in tumor group, no significant difference was detected...
2016: PloS One
Quanwei Zhang, Ruben Nogales-Cadenas, Jhih-Rong Lin, Wen Zhang, Ying Cai, Jan Vijg, Zhengdong D Zhang
Although studies over the last decades have firmly connected a number of genes and molecular pathways to aging, the aging process as a whole still remains poorly understood. To gain novel insights into the mechanisms underlying aging, instead of considering aging genes individually, we studied their characteristics at the systems level in the context of biological networks. We calculated a comprehensive set of network characteristics for human aging-related genes from the GenAge database. By comparing them with other functional groups of genes, we identified a robust group of aging-specific network characteristics...
May 14, 2016: Human Molecular Genetics
Mengxiong Sun, Chenghao Zhou, Hui Zeng, Fei Yin, Zhuoying Wang, Jianzhong Yao, Yingqi Hua, Zhengdong Cai
In this study, we evaluated the photodynamic efficacy of a new photosensitizer, benzochloroporphyrin derivative 18 (BCPD-18), in Ewing sarcoma. We found that BCPD-18 decreased the viability of TC-71 cells irradiated by 670nm laser in a concentration dependent manner. We also observed cells undergoing apoptosis as well as cell cycle arrest at the G2M phase after BCPD-18-mediated photodynamic therapy (BCPD-PDT). In addition, in vivo study (subcutaneous and orthotopic models) showed that BCPD-PDT reduced tumor size, tumor weight and tumor-bearing leg weight...
July 2016: Journal of Photochemistry and Photobiology. B, Biology
Shizhi Wang, Shenshen Wu, Haixia Zhu, Bo Ding, Yunlang Cai, Jing Ni, Qiang Wu, Qingtao Meng, Xin Zhang, Chengcheng Zhang, Xiaobo Li, Meilin Wang, Rui Chen, Hua Jin, Zhengdong Zhang
Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. Given PSCA is reported to be overexpressed in cervical cancer and the rs2294008 can influence PSCA transcription, we aimed to determine the role of rs2294008 in susceptibility to cervical cancer. The genotyping was performed in the 1126 cases and 1237 controls...
2016: Scientific Reports
Chao Qin, Qiang Cao, Pu Li, Shangqian Wang, Jian Wang, Meilin Wang, Haiyan Chu, Liqun Zhou, Xuesong Li, Dingwei Ye, Hailiang Zhang, Yiran Huang, Baijun Dong, Xiaofeng Sun, Qing Zou, Hongzhou Cai, Lijiang Sun, Jian Zhu, Fade Liu, Junbiao Ji, Li Cui, Xiaoxiang Wang, Hai Zhou, Hu Zhao, Bin Wu, Jianchun Chen, Minjun Jiang, Zhengdong Zhang, Pengfei Shao, Xiaobing Ju, Changjun Yin
The purpose of the present study was to investigate whether genetic variants that influence angiogenesis and sorafenib pharmacokinetics are associated with clinical outcomes and toxic effects in advanced renal cell carcinoma patients treated with this drug. One hundred patients with advanced renal cell carcinoma were enrolled. Forty-two polymorphisms in 15 genes were selected for genotyping and analyzed for associations with progression-free survival, overall survival, and toxic effects. We found that rs1570360 in VEGF and rs2239702 in VEGFR2 were significantly associated with progression-free...
2016: Scientific Reports
Jun Gu, Yingjie Ni, Lin Xu, Hongliang Xu, Zhengdong Cai
Previous research had reported transcription factors Nanog expressed in pluripotent embryonic stem cells (ESCS) that played an important role in regulating the cell proliferation. Nanog levels are frequently elevated in ESCS, but the role in the spinal cord was not clear. To examine the biological relevance of Nanog, we studied its properties in spinal cord injury model. The expression of Nanog and PCNA was gradually increased and reached a peak at 3 day by western blot analysis. The expression of Nanog was further analyzed by immunohistochemistry...
January 22, 2016: Biochemical and Biophysical Research Communications
Xiaojun Ma, Wei Sun, Jiakang Shen, Yingqi Hua, Fei Yin, Mengxiong Sun, Zhengdong Cai
The gelsolin (GSN) has been involved in the regulation of tumor formation and development, but the biological role of GSN in the pathogenesis of osteosarcoma (OS) has not been well characterized. In this study, we show that high expression of GSN was observed in OS tissues and correlated with tumor size, advanced Enneking stage, and poor patient prognosis. Knockdown of GSN significantly inhibited cell proliferation and invasiveness in the OS cell lines. Furthermore, stable overexpression of GSN in OS cells resulted in a significant increase in cell growth and motility with the downregulation of p-AKT and p-P38 pathway...
June 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Xiaojun Ma, Sun Wei, Chunxi Yang, Yingqi Hua, Jiakang Shen, Zhengdong Cai
BACKGROUND: The goal of the present study was to assess the effects of computed tomography (CT)-guided iodine-125 (125I) seed implantation or gelatin sponge particle (GSP) embolization on patients with giant benign sacral neurogenic tumors. METHODS: A total of 24 cases with giant sacral neurogenic tumor were performed in a retrospective study between 2000 and 2012. Nineteen cases received surgical resection, and five cases received non-surgical treatment. In surgical group, patients with type III sacral tumor had received a combined anterior-posterior approach and patients with type IV were treated with simple anterior approach...
2015: World Journal of Surgical Oncology
Quanchi Chen, Zifei Zhou, Liancheng Shan, Hui Zeng, Yingqi Hua, Zhengdong Cai
Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previous studies have suggested that Src has essential functions in cell proliferation, apoptosis, invasion, metastasis and the tumor microenvironment. Thus, it may be a potential target for cancer therapy...
July 2015: Oncology Letters
Jonathan H Chung, Jinlu Cai, Barrie G Suskin, Zhengdong Zhang, Karlene Coleman, Bernice E Morrow
The 22q11.2 deletion syndrome (22q11DS) affects 1:4,000 live births and presents with highly variable phenotype expressivity. In this study, we developed an analytical approach utilizing whole-genome sequencing (WGS) and integrative analysis to discover genetic modifiers. Our pipeline combined available tools in order to prioritize rare, predicted deleterious, coding and noncoding single-nucleotide variants (SNVs), and insertion/deletions from WGS. We sequenced two unrelated probands with 22q11DS, with contrasting clinical findings, and their unaffected parents...
August 2015: Human Mutation
Dong Fu, Wei Sun, Jiakang Shen, Xiaojun Ma, Zhengdong Cai, Yingqi Hua
Inflammatory pseudotumor has been commonly reported in patients undertaking total hip replacement (THR) for different reasons. The precise etiology of this biological reaction and whether the primary disease has an influence on pseudotumor formation remain unclear. There seems to be a consensus that metal ions and debris do play an important role during this process. Recently, however, compared to metal particles along, immune response induced by metal particles attracts more attention. We present two cases of pseudotumor who have accepted THR for ankylosing spondylitis (AS) and later required revision surgery and hindquarter amputation, respectively...
2015: World Journal of Surgical Oncology
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No abstract text is available yet for this article.
2015: Journal of Orthopaedic Surgery and Research
Zifei Zhou, Yingqi Hua, Junjian Liu, Dongqing Zuo, Hongsheng Wang, Quanchi Chen, Longpo Zheng, Zhengdong Cai
PURPOSE: Glucocorticoid-induced osteonecrosis of the femoral head (GC-induced ONFH) is a rebarbative disease affecting people from all ages, especially young adults, and often leads to severe joint pain and limitations on physical activity. Numerous studies have reported that ABCB1 polymorphisms are associated with GC-induced ONFH, but the results are inconclusive, partially because the sample size of published studies is relatively small. Therefore, we performed a meta-analysis including seven case-control studies to estimate such association...
September 10, 2015: Gene
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