Yafei Jiang, Jinzeng Wang, Mengxiong Sun, Dongqing Zuo, Hongsheng Wang, Jiakang Shen, Wenyan Jiang, Haoran Mu, Xiaojun Ma, Fei Yin, Jun Lin, Chongren Wang, Shuting Yu, Lu Jiang, Gang Lv, Feng Liu, Linghang Xue, Kai Tian, Gangyang Wang, Zifei Zhou, Yu Lv, Zhuoying Wang, Tao Zhang, Jing Xu, Liu Yang, Kewen Zhao, Wei Sun, Yujie Tang, Zhengdong Cai, Shengyue Wang, Yingqi Hua
Osteosarcoma (OS) is a primary malignant bone tumor that most commonly affects children, adolescents, and young adults. Here, we comprehensively analyze genomic, epigenomic and transcriptomic data from 121 OS patients. Somatic mutations are diverse within the cohort, and only TP53 is significantly mutated. Through unsupervised integrative clustering of the multi-omics data, we classify OS into four subtypes with distinct molecular features and clinical prognosis: (1) Immune activated (S-IA), (2) Immune suppressed (S-IS), (3) Homologous recombination deficiency dominant (S-HRD), and (4) MYC driven (S-MD)...
November 23, 2022: Nature Communications