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https://www.readbyqxmd.com/read/29662067/author-correction-radioligand-binding-analysis-of-%C3%AE-2-adrenoceptors-with-11-c-yohimbine-in-brain-in-vivo-extended-inhibition-plot-correction-for-plasma-protein-binding
#1
Jenny-Ann Phan, Anne M Landau, Steen Jakobsen, Dean F Wong, Albert Gjedde
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29617215/phrenic-long-term-depression-evoked-by-intermittent-hypercapnia-is-modulated-by-serotonergic-and-adrenergic-receptors-in-raphe-nuclei
#2
Ivona Stipica Safic, Renata Pecotic, Ivana Pavlinac Dodig, Zoran Dogas, Zoran Valic, Maja Valic
Intermittent hypercapnia evokes prolonged depression of phrenic nerve activity (phrenic long-term depression, pLTD). This study was undertaken to investigate the role of 5-HT and α2-adrenergic receptors in the initiation of pLTD. Adult, male, urethane-anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats were exposed 5 acute intermittent hypercapnias (15% CO2 in air). Experimental group received microinjection of selective 5-HT1A receptors agonist 8-OH-DPAT, broad spectrum 5-HT antagonist methysergide or α2-adrenergic antagonist yohimbine, whereas control group received microinjection of 0...
April 4, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29616881/the-use-of-ketamine-xylazine-or-butorphanol-azaperone-medetomidine-to-immobilize-american-black-bears-ursus-americanus
#3
Ryan H Williamson, Lisa L Muller, Coy Blair
  Wildlife anesthetic protocols must offer rapid inductions and recoveries, be physiologically safe, and be minimally regulated. With this in mind, we evaluated differences in induction and recovery times and physiological parameters in 33 American black bears ( Ursus americanus) anesthetized with ketamine-xylazine (KX) or immobilized with a commercial drug combination of butorphanol, azaperone, and medetomidine (BAM). Dose was based on mass estimated from field observations. Bears were housed at Appalachian Bear Rescue, Townsend, Tennessee, US, or free-ranging within the Great Smoky Mountains National Park (Tennessee and North Carolina, US) and chemically immobilized for management purposes...
April 4, 2018: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29577284/regulation-of-eye-and-jaw-colouration-in-three-spined-stickleback-gasterosteus-aculeatus
#4
L Franco-Belussi, C De Oliveira, H N Sköld
Fish can change their skin and eye colour for background matching and signalling. Males of Gasterosteus aculeatus develop ornamental blue eyes and a red jaw during the reproductive season, colours that are further enhanced during courtship. Here, the effects of different hormones on physiological colour changes in the eyes and jaws of male and female G. aculeatus were investigated in vitro. In an in vivo experiment, G. aculeatus were injected with a receptor blocker of a pivotal hormone (noradrenaline) that controls colour change...
March 25, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29572652/differential-regulation-of-alcohol-taking-and-seeking-by-antagonism-at-%C3%AE-4%C3%AE-2-and-%C3%AE-3%C3%AE-4-nachrs
#5
Andrea Cippitelli, Gloria Brunori, Jennifer Schoch, Christopher J Armishaw, Jinhua Wu, Nurulain T Zaveri, Marc A Giulianotti, Gregory S Welmaker, Lawrence Toll
RATIONALE: Alcoholism is a serious public health problem throughout the world. Current pharmacotherapies for the treatment of this disorder are poorly effective. Preclinical and clinical findings point to nicotinic acetylcholine receptors (nAChRs) as a promising target for the development of novel and effective medications. Assuage Pharmaceuticals, in collaboration with Torrey Pines Institute for Molecular Studies, has discovered a new class of potent and selective α4β2 nAChR antagonists...
March 23, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29530492/agmatine-inhibits-nicotine-withdrawal-induced-cognitive-deficits-in-inhibitory-avoidance-task-in-rats-contribution-of-%C3%AE-2-adrenoceptors
#6
Nandkishor R Kotagale, Mir Touseef Ali, Chandrabhan T Chopde, Milind J Umekar, Brijesh G Taksande
Nicotine abstinence following chronic exposure is associated with impairments in memory and variety of cognitive functions. Daily nicotine (2 mg/kg, sc, four times daily) administration for 14 days and its abrupt withdrawal significantly impaired avoidance learning in inhibitory avoidance task as indicated by a significant decrease in the step through latency. Animals injected with agmatine (10-40 μg/rat, icv) from day 7 to 14 before the first daily dose of nicotine (2 mg/kg, sc) showed increased step through latencies during retrieval test...
April 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29522726/valnoctamide-the-effect-on-relieving-of-neuropathic-pain-and-possible-mechanisms
#7
Dilara Nemutlu Samur, Rana Arslan, Sule Aydın, Nurcan Bektas
The purpose of this study is to assess the possible anti-allodynic and antihyperalgesic effect of valnoctamide, an amide derivative of valproic acid, at the doses of 40, 70 and 100 mg/kg (i.p.) in neuropathic pain model induced by chronic constriction injury in rats, by using dynamic plantar test and plantar test (Hargreaves method), and to evaluate that the possible role of certain serotonin, noradrenergic, opioid and GABAergic receptors by pre-treatment with 1 mg/kg (i.p.) ketanserin, yohimbine, naloxone and 0...
March 6, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29510084/dexmedetomidine-reduces-ventilator-induced-lung-injury-vili-by-inhibiting-toll-like-receptor-4-tlr4-nuclear-factor-nf-%C3%AE%C2%BAb-signaling-pathway
#8
Hongli Chen, Xiaotong Sun, Xiaomei Yang, Yonghao Hou, Xiaoqian Yu, Yang Wang, Jianbo Wu, Dejie Liu, Huanliang Wang, Jingui Yu, Wenbo Yi
Mechanical ventilation (MV) may lead to ventilator-induced lung injury (VILI). Previous research has shown that dexmedetomidine attenuates pulmonary inflammation caused by MV, but the underlying mechanisms remain unclear. Our study aims to test whether dexmedetomidine has a protective effect against VILI and to explore the possible molecular mechanisms using the rat model. Thirty adult male Wistar rats weighing 200-250 g were randomly assigned to 5 groups (n = 6): control, low tidal volume MV (LMV), high tidal volume (HVT) MV (HMV), HVT MV + dexmedetomidine (DEX), HVT MV + dexmedetomidine + yohimbine (DEX+Y)...
February 20, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29504865/novel-effect-of-%C3%AE-lactalbumin-on-the-yohimbine-induced-hot-flush-increase-of-the-tail-skin-temperature-in-ovariectomized-rats
#9
Masayuki Uchida, Orie Kobayashi
5-Hydroxytryptamine (5-HT) and noradrenaline have been thought to play important roles in the mechanism of hot flush. Then, to clarify the relation between serotonergic and adrenergic nervous systems on the mechanism of hot flush, the effect of paroxetine, 5-HT reuptake inhibitor (SSRI) was evaluated on the yohimbine-induced hot flush increase of tail skin temperature in ovariectomized female rats. Yohimbine (adrenaline α2 antagonist) significantly increased the tail skin temperature in course of time. Clonidine (adrenaline α2 agonist) significantly attenuated this effect...
March 5, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29489444/opposite-effect-of-opuntia-ficus-indica-l-juice-depending-on-fruit-maturity-stage-on-gastrointestinal-physiological-parameters-in-rat
#10
Kais Rtibi, Slimen Selmi, Dhekra Grami, Mohamed Amri, Hichem Sebai, Lamjed Marzouki
The phytochemical composition and the effect of the green and ripe Opuntia ficus-indica juice on some gastrointestinal (GI) physiological parameters such as stomach emptying and small-intestinal motility and permeability were determined in rats administered multiple concentrations of the prickly pear juice (5, 10, and 20 mL kg-1 , b.w., p.o.). Other separate groups of rats were received, respectively; sodium chloride (0.9%, b.w., p.o.), clonidine (α-2 -adrenergic agonist, 1 mg kg-1 , b.w., i.p.), yohimbine (α-2 -adrenergic antagonist, 2 mg kg-1 , b...
February 28, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29488014/tyraminergic-modulation-of-agonistic-outcomes-in-crayfish
#11
Yuto Momohara, Hitoshi Aonuma, Toshiki Nagayama
Octopamine, a biogenic amine, modulates various behaviors, ranging from locomotion and aggression to learning and memory in invertebrates. Several studies recently demonstrated that tyramine, the biological precursor of octopamine, also affects behaviors independent of octopamine. Here we investigated the involvement of tyramine in agonistic interaction of the male crayfish Procambarus clarkii. When male crayfish fight, larger animals (3-7% difference in body length) are more likely to win. By contrast, direct injection of tyramine or octopamine counteracted the physical advantage of larger animals...
February 27, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29466417/epinephrine-modulates-na-k-atpase-activity-in-caco-2-cells-via-src-p38mapk-erk-and-pge2
#12
Layla El Moussawi, Mohamed Chakkour, Sawsan I Kreydiyyeh
Epinephrine, a key stress hormone, is known to affect ion transport in the colon. Stress has been associated with alterations in colonic functions leading to changes in water movements manifested as diarrhea or constipation. Colonic water movement is driven by the Na+-gradient created by the Na+/K+-ATPase. Whether epinephrine acts via an effect on the Na+/K+-ATPase hasn't been studied before. The aim of this work was to investigate the effect of epinephrine on the Na+/K+-ATPase and to elucidate the signaling pathway involved using CaCo-2 cells as a model...
2018: PloS One
https://www.readbyqxmd.com/read/29454007/destruction-of-noradrenergic-terminals-increases-dopamine-concentration-and-reduces-dopamine-metabolism-in-the-medial-prefrontal-cortex
#13
Rita Gálosi, Zoltán Petykó, Veronika Kállai, Attila Tóth, Tamás Ollmann, László Péczely, Anita Kovács, Beata Berta, László Lénárd
Effects of destroyed noradrenergic (NE) innervation in the medial prefrontal cortex (mPFC) were examined on dopamine (DA) content and metabolism. 6-hydroxy-DOPA (6-OHDOPA) or 6-hydroxy-dopamine (6-OHDA) in combination with a potent DA reuptake inhibitor GBR 12935 or 6-OHDA were injected bilaterally into the mPFC in separate groups of animals. In addition, GBR 12935 or vehicle was injected into the mPFC in two other groups of animals as control experiments. NE and DA concentrations from postmortem tissue of the mPFC were measured using HPLC with electrochemical detection...
February 14, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29448886/augmenting-treatment-efficiency-in-exposure-therapy-for-ptsd-a-randomized-double-blind-placebo-controlled-trial-of-yohimbine-hcl
#14
Peter W Tuerk, Bethany C Wangelin, Mark B Powers, Jasper A J Smits, Ron Acierno, Ursula S Myers, Scott P Orr, Edna B Foa, Mark B Hamner
The alpha-2 adrenergic receptor antagonist, yohimbine, can facilitate fear extinction in animals and humans. One potential mechanism is increased noradrenergic activity and associated arousal in the presence of conditioned stimuli. Accordingly, yohimbine might augment prolonged exposure (PE) therapy for posttraumatic stress disorder (PTSD), where heightened exposure-oriented arousal is a theorized driver and empirical predictor of treatment success. A double-blind placebo-controlled randomized trial (NCT 01031979) piloted yohimbine augmentation in 26 males with combat-related PTSD...
February 15, 2018: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/29424320/reserpine-induces-apoptosis-and-cell-cycle-arrest-in-hormone-independent-prostate-cancer-cells-through-mitochondrial-membrane-potential-failure
#15
Manjula Devi Ramamoorthy, Ashok Kumar, Mahesh Ayyau, Kannan Narayanan Dhiraviam
Reserpine, an indole alkaloid commonly used for hypertension, is found in the roots of Rauwolfia serpentina. Although the root extract has been used for the treatment of cancer, the molecular mechanism of its anti-cancer activity on hormonal independent prostate cancer remains elusive. Therefore, we evaluated the cytotoxicity of reserpine and other indole alkaloids, yohimbine and ajmaline on prostate cancer cells (PC3) using MTT assay. We investigated the mechanism of apoptosis using a combination of techniques including acridine orange/ethidium bromide staining, high content imaging of Annexin V-FITC staining, flow cytometric quantification of the mitochondrial membrane potential and reactive oxygen species (ROS) and cell cycle analysis...
February 9, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29412228/the-protective-effect-of-dexmedetomidine-in-a-rat-ex-vivo-lung-model-of-ischemia-reperfusion-injury
#16
Yan Zhou, Xinqiao Zhou, Wenjuan Zhou, Qingfeng Pang, Zhiping Wang
PURPOSE: To investigate the effect of dexmedetomidine (Dex) in a rat ex vivo lung model of ischemia-reperfusion injury. METHODS: An IL-2 ex vivo lung perfusion system was used to establish a rat ex vivo lung model of ischemia-reperfusion injury. Drugs were added to the perfusion solution for reperfusion. Lung injury was assessed by histopathological changes, airway pressure (Res), lung compliance (Compl), perfusion flow (Flow), pulmonary venous oxygen partial pressure (PaO2), and lung wet/dry (W/D) weight ratio...
January 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29408007/neuropharmacological-characterization-of-frutalin-in-mice-evidence-of-an-antidepressant-like-effect-mediated-by-the-nmda-receptor-no-cgmp-pathway
#17
João Ronielly Campêlo Araújo, José de Maria Albuquerque de Melo Júnior, Marina de Barros Mamede Vidal Damasceno, Sacha Aubrey Alves Rodrigues Santos, Antônio Eufrásio Vieira-Neto, Marina Duarte Pinto Lobo, Adriana Rolim Campos, Renato de Azevedo Moreira, Ana Cristina de Oliveira Monteiro-Moreira
In this study we evaluated the effect of frutalin (FTL) on mouse behavior. Mice (n = 6/group) were treated (i.p.) with FTL (0.25; 0.5 or 1 mg/kg) or vehicle and submitted to several tests (hole-board/HBT, elevated plus maze/PMT, open field/OFT, tail suspension/TST, or forced swimming/FST). Yohimbine, ketamine, l-NAME, aminoguanidine, 7-NI, methylene blue, l-arginine or dl-serine was administered 30 min before FTL (0.5 mg/kg). To evaluate the subchronic effect, animals were injected with FTL or vehicle for 7 days and submitted to the FST...
January 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29407513/dissociable-roles-of-glucocorticoid-and-noradrenergic-activation-on-social-discounting
#18
Zsofia Margittai, Marijn van Wingerden, Alfons Schnitzler, Marian Joëls, Tobias Kalenscher
People often exhibit prosocial tendencies towards close kin and friends, but generosity decreases as a function of increasing social distance between donor and recipient, a phenomenon called social discounting. Evidence suggests that acute stress affects prosocial behaviour in general and social discounting in particular. We tested the causal role of the important stress neuromodulators cortisol (CORT) and noradrenaline (NA) in this effect by considering two competing hypotheses. On the one hand, it is possible that CORT and NA act in concert to increase generosity towards socially close others by reducing the aversiveness of the cost component in costly altruism and enhancing the emotional salience of vicarious reward...
January 31, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29382555/reliability-and-robustness-of-feedback-evoked-brain-heart-coupling-after-placebo-dopamine-and-noradrenaline-challenge
#19
Maximilian Lueckel, Christian Panitz, Urs M Nater, Erik M Mueller
External and internal performance feedback triggers not only neural but also cardiac modulations, suggesting communication between brain and heart during feedback processing. Using Cardio-Electroencephalographic Covariance Tracing (CECT), it has accordingly been shown that feedback-evoked centromedial single-trial EEG at the P300 latency intraindividually predicts subsequent changes in heart period - the so called N300H phenomenon. While previous findings suggest that the N300H depends on serotonin, its relationship to central dopamine and noradrenaline is currently unknown...
January 27, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29374304/differences-in-trait-impulsivity-do-not-bias-the-response-to-pharmacological-drug-challenge-in-the-rat-five-choice-serial-reaction-time-task
#20
Rebecca L Barlow, Jeffrey W Dalley, Anton Pekcec
RATIONALE: Maladaptive impulsivity is symptomatic of several neuropsychiatric disorders including schizophrenia, attention-deficit hyperactivity disorder (ADHD), and substance abuse disorders; paradigms designed to assess the underlying neurobiology of this behavior are essential for the discovery of novel therapeutic agents. Various models may be used to assess impulsivity as measured by the five-choice serial reaction time task (5-CSRTT), including variable inter-trial interval (ITI) sessions, the selection of extreme high and low impulsivity phenotypes from a large outbred population of rats, as well as pharmacological challenges...
January 26, 2018: Psychopharmacology
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