keyword
https://read.qxmd.com/read/33764892/antibacterial-properties-of-capsaicin-and-its-derivatives-and-their-potential-to-fight-antibiotic-resistance-a-literature-survey
#21
REVIEW
Samuel Füchtbauer, Soraya Mousavi, Stefan Bereswill, Markus M Heimesaat
Antibiotic resistance is endangering public health globally and gives reason for constant fear of virtually intractable bacterial infections. Given a limitation of novel antibiotic classes brought to market in perspective, it is indispensable to explore novel, antibiotics-independent ways to fight bacterial infections. In consequence, the antibacterial properties of natural compounds have gained increasing attention in pharmacological sciences. We here performed a literature survey regarding the antibacterial effects of capsaicin and its derivatives constituting natural compounds of chili peppers...
March 24, 2021: European Journal of Microbiology & Immunology
https://read.qxmd.com/read/33383571/capsaicinoid-and-capsinoids-as-an-ergogenic-aid-a-systematic-review-and-the-potential-mechanisms-involved
#22
JOURNAL ARTICLE
Vilton E L de Moura E Silva, Jason M Cholewa, François Billaut, Ralf Jäger, Marcelo C de Freitas, Fabio S Lira, Fabrício E Rossi
CONTEXT: Capsaicinoids and capsinoids (CAP) are natural substances found primarily in chili peppers and other spicy foods that agonize the transient receptor potential vanilloid-1 in the mouth, stomach, and small intestine. Several studies have shown CAP to be a potential antiobesity agent and to exhibit an analgesic effect in both rodents and humans. However, there is no scientific consensus about the effects of CAP on physical exercise performance and its physiological mechanisms of action...
April 1, 2021: International Journal of Sports Physiology and Performance
https://read.qxmd.com/read/33300660/the-beneficial-effects-of-red-sun-dried-capsicum-annuum-l-cv-senise-extract-with-antioxidant-properties-in-experimental-obesity-are-associated-with-modulation-of-the-intestinal-microbiota
#23
JOURNAL ARTICLE
Chiara Sinisgalli, Teresa Vezza, Patricia Diez-Echave, Angela Ostuni, Immacolata Faraone, Laura Hidalgo-Garcia, Daniela Russo, Maria Francesca Armentano, José Garrido-Mesa, Maria Elena Rodriguez-Cabezas, Alba Rodríguez-Nogales, Luigi Milella, Julio Galvez
SCOPE: Capsicum annuum L. cv Senise is a sweet pepper containing health promoting compounds that can be modified by ripening and drying. This study focuses on finding the peppers with the best antioxidant properties, which are evaluated on an experimental model of obesity. METHODS AND RESULTS: Phytochemical profile and antioxidant activity are evaluated on several peppers obtained from the same cultivar at different ripening stages. Red sweet peppers show the highest content in polyphenols, β-carotene, lycopene, and capsinoids, and demonstrate the best antioxidant activity in vitro...
February 2021: Molecular Nutrition & Food Research
https://read.qxmd.com/read/33276488/capsaicin-and-gut-microbiota-in-health-and-disease
#24
REVIEW
Adrian Eugen Rosca, Mara Ioana Iesanu, Carmen Denise Mihaela Zahiu, Suzana Elena Voiculescu, Alexandru Catalin Paslaru, Ana-Maria Zagrean
Capsaicin is a widespread spice known for its analgesic qualities. Although a comprehensive body of evidence suggests pleiotropic benefits of capsaicin, including anti-inflammatory, antioxidant, anti-proliferative, metabolic, or cardioprotective effects, it is frequently avoided due to reported digestive side-effects. As the gut bacterial profile is strongly linked to diet and capsaicin displays modulatory effects on gut microbiota, a new hypothesis has recently emerged about its possible applicability against widespread pathologies, such as metabolic and inflammatory diseases...
December 2, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/33129596/the-effects-of-capsinoids-and-fermented-red-pepper-paste-supplementation-on-blood-pressure-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#25
JOURNAL ARTICLE
Mohammad Reza Amini, Fatemeh Sheikhhossein, Elham Bazshahi, Mahdi Hajiaqaei, Anahid Shafie, Hossein Shahinfar, Neda Azizi, Hadi Eghbaljoo Gharehgheshlaghi, Sina Naghshi, Raana Babadi Fathipour, Sakineh Shab-Bidar
BACKGROUND & AIMS: The present systematic review and meta-analysis were conducted to investigate the effects of capsinoids and fermented red pepper paste (FRPP) supplementation on Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP). METHODS: Relevant studies, published up to May 2020, were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. All randomized clinical trials investigating the effect of capsinoids and FRPP supplementation on blood pressure including SBP and DBP were included...
October 24, 2020: Clinical Nutrition
https://read.qxmd.com/read/33063385/the-effect-of-capsaicinoids-or-capsinoids-in-red-pepper-on-thermogenesis-in-healthy-adults-a-systematic-review-and-meta-analysis
#26
JOURNAL ARTICLE
Pardis Irandoost, Neda Lotfi Yagin, Nazli Namazi, Abbasali Keshtkar, Farnaz Farsi, Naimeh Mesri Alamdari, Mohammadreza Vafa
The outcomes of the earlier trials are controversial concerning the effect of Capsaicinoids/Capsinoids on thermogenesis. We carried out this systematic review and meta-analysis to examine the effect of Capsaicinoids/Capsinoids on thermogenesis indices including resting metabolic rate (RMR) and respiratory quotient (RQ) in healthy adults. An electronic literature search was conducted between 1990 and 2019, using the following databases: PubMed, Web of Sciences, Scopus, Cochrane Central Register of Controlled Trials, and EMBASE...
March 2021: Phytotherapy Research: PTR
https://read.qxmd.com/read/32957596/content-of-capsaicinoids-and-capsiate-in-filius-pepper-varieties-as-affected-by-ripening
#27
JOURNAL ARTICLE
Mercedes Vázquez-Espinosa, Oreto Fayos, Ana V González-de-Peredo, Estrella Espada-Bellido, Marta Ferreiro-González, Miguel Palma, Ana Garcés-Claver, Gerardo F Barbero
Peppers are fruits with wide genetic variability and multiple ways of being consumed that hold a relevant position in the human diet. Nowadays, consumers are interested in new gastronomic experiences provided by pepper cultivars that present new shapes, colors, and flavors while preserving their bioactive compounds, such as their capsaicinoids and capsinoids. However, numerous changes take place during their development that may alter their biological properties. Therefore, this work evaluates the capsaicinoid and capsiate contents in two traditional varieties of ornamental peppers ("Filius Blue" and "Filius Green'") during fruit maturation...
September 17, 2020: Plants (Basel, Switzerland)
https://read.qxmd.com/read/32927664/effects-of-nutrition-diet-on-brown-adipose-tissue-in-humans-a-systematic-review-and-meta-analysis
#28
REVIEW
Kelsey A Heenan, Andres E Carrillo, Jacob L Fulton, Edward J Ryan, Jason R Edsall, Dimitrios Rigopoulos, Melissa M Markofski, Andreas D Flouris, Petros C Dinas
BACKGROUND: Brown adipose tissue (BAT) provides a minor contribution to diet-induced thermogenesis (DIT)-the metabolic response to food consumption. Increased BAT activity is generally considered beneficial for mammalian metabolism and has been associated with favorable health outcomes. The aim of the current systematic review was to explore whether nutritional factors and/or diet affect human BAT activity. METHODS: We searched PubMed Central, Embase and Cochrane Library (trials) to conduct this systematic review (PROSPERO protocol: CRD42018082323)...
September 10, 2020: Nutrients
https://read.qxmd.com/read/32887379/effects-of-capsinoid-intake-on-brown-adipose-tissue-vascular-density-and-resting-energy-expenditure-in-healthy-middle-aged-adults-a-randomized-double-blind-placebo-controlled-study
#29
RANDOMIZED CONTROLLED TRIAL
Sayuri Fuse, Tasuki Endo, Riki Tanaka, Miyuki Kuroiwa, Akira Ando, Ayami Kume, Akiko Yamamoto, Kanna Kuribayashi, Shinji Somekawa, Masamichi Takeshita, Masaki Hashimoto, Ryotaro Kime, Yuko Kurosawa, Takafumi Hamaoka
Capsinoids are some of the most promising ingredients to increase energy expenditure (EE) due to brown adipose tissue (BAT) activation. However, there is limited information regarding the effect of prolonged capsinoid ingestion (CI) on BAT activity and resting EE (REE) in healthy, middle-aged, normal to overweight subjects (Subhealthy ) with distinct BAT characteristics. We examined the changes in BAT density (BAT-d), using near-infrared time-resolved spectroscopy, and REE/kg induced by daily CI. Forty Subhealthy [age, 43...
September 2, 2020: Nutrients
https://read.qxmd.com/read/32838710/effect-of-capsinoids-supplementation-on-fat-oxidation-and-muscle-glycogen-restoration-during-post-exercise-recovery-in-humans
#30
JOURNAL ARTICLE
Su-Fen Liao, Mallikarjuna Korivi, Jung-Piao Taso, Chun-Ching Huang, Chia-Chen Chang, I-Shiung Cheng
Capsinoids (CSN), the novel non-pungent capsaicin analogs have been reported to promote metabolic health and exercise tolerance. However, the effect of CSN on fat oxidation and changes in skeletal muscle glycogen levels during post-exercise recovery has not been investigated in humans. <P> Purpose: We examined the effect of CSN supplementation on energy reliance, glycogen resynthesis and molecular proteins in the skeletal muscle of young adults during post-exercise recovery. <P> Methods: In this crossover-designed study, nine healthy adult male volunteers (aged 21...
August 23, 2020: Current Pharmaceutical Design
https://read.qxmd.com/read/32541662/a-feedforward-loop-within-the-thyroid-brown-fat-axis-facilitates-thermoregulation
#31
JOURNAL ARTICLE
Lijuan Sun, Hui Jen Goh, Priya Govindharajulu, Lei Sun, Christiani Jeyakumar Henry, Melvin Khee-Shing Leow
Thyroid hormones (TH) control brown adipose tissue (BAT) activation and differentiation, but their subsequent homeostatic response following BAT activation remains obscure. This study aimed to investigate the relationship between cold- and capsinoids-induced BAT activation and TH changes between baseline and 2 hours post-intervention. Nineteen healthy subjects underwent 18 F-fluorodeoxyglucose positron-emission tomography (18 F-FDG PET) and whole-body calorimetry (WBC) after 2 hours of cold exposure (~14...
June 15, 2020: Scientific Reports
https://read.qxmd.com/read/32471326/characterization-of-newly-developed-pepper-cultivars-capsicum-chinense-dieta0011-0301-dieta0011-0602-dieta0041-0401-and-dieta0041-0601-containing-high-capsinoid-concentrations-and-a-strong-fruity-aroma
#32
JOURNAL ARTICLE
Tetsuya Seki, Masafumi Ota, Hiroto Hirano, Kiyotaka Nakagawa
Capsaicinoids are responsible for the pungent flavor of peppers ( Capsicum sp.). The cultivar CH-19 Sweet is a non-pungent pepper mutant that biosynthesizes the low-pungent capsaicinoid analogs, capsinoids. Capsinoids possess important pharmaceutical properties. However, capsinoid concentrations are very low in CH-19 Sweet, and Capsicum cultivars with high content capsinoids are desirable for industrial applications of capsinoids. Habanero, Bhut Jolokia, and Infinity are species of Capsicum chinense , and have strong pungency and intense fruity flavors...
May 29, 2020: Bioscience, Biotechnology, and Biochemistry
https://read.qxmd.com/read/32429083/phytochemical-profile-of-capsicum-annuum-l-cv-senise-incorporation-into-liposomes-and-evaluation-of-cellular-antioxidant-activity
#33
JOURNAL ARTICLE
Chiara Sinisgalli, Immacolata Faraone, Antonio Vassallo, Carla Caddeo, Faustino Bisaccia, Maria Francesca Armentano, Luigi Milella, Angela Ostuni
Overproduction of oxidants in the human body is responsible for oxidative stress, which is associated with several diseases. High intake of vegetables and fruits can reduce the risk of chronic diseases, as they are sources of bioactive compounds capable of contrasting the free radical effects involved in cancer, obesity, diabetes, and neurodegenerative and cardiovascular diseases. Capsicum annuum L. cv Senise is a sweet pepper that is grown in the Basilicata region (Italy). It is an important source of polyphenols, carotenoids, and capsinoids and can play a key role in human health...
May 15, 2020: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/32373072/brown-adipose-tissue-diet-induced-thermogenesis-and-thermogenic-food-ingredients-from-mice-to-men
#34
REVIEW
Masayuki Saito, Mami Matsushita, Takeshi Yoneshiro, Yuko Okamatsu-Ogura
Since the recent rediscovery of brown adipose tissue (BAT) in adult humans, this thermogenic tissue has been attracting increasing interest. The inverse relationship between BAT activity and body fatness suggests that BAT, because of its energy dissipating activity, is protective against body fat accumulation. Cold exposure activates and recruits BAT, resulting in increased energy expenditure and decreased body fatness. The stimulatory effects of cold exposure are mediated through transient receptor potential (TRP) channels and the sympathetic nervous system (SNS)...
2020: Frontiers in Endocrinology
https://read.qxmd.com/read/32212928/factors-affecting-the-capsaicinoid-profile-of-hot-peppers-and-biological-activity-of-their-non-pungent-analogs-capsinoids-present-in-sweet-peppers
#35
REVIEW
Virgílio Gavicho Uarrota, Marcelo Maraschin, Ângela de Fátima M de Bairros, Romina Pedreschi
Capsaicinoids are acid amides of C9 -C11 branched-chain fatty acids and vanillylamine and constitute important chemical compounds of Capsicum annuum together with their non-pungent analogs (capsinoids) which have an impressive list of health benefit properties (i.e., analgesia, anti-obesity, thermogenic, cardiovascular, gastrointestinal, antioxidant, anti-bacterial, anti-virulence, anti-inflamatory, anti-diabetic, inhibits angiogenesis, and improves glucose metabolism) . In this review, the state of art on how capsaicinoids are affected by different pre- and postharvest factors is discussed together with their biological activity...
2021: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/31947529/effects-of-capsinoids-on-daily-physical-activity-body-composition-and-cold-hypersensitivity-in-middle-aged-and-older-adults-a-randomized-study
#36
JOURNAL ARTICLE
Keiichi Yokoyama, Yosuke Yamada, Yasunori Akamatsu, Yasuko Yoshinaka, Akiko Yamamoto, Tomonori Koizumi, Kana Ohyama, Katsuya Suzuki, Masaki Hashimoto, Hitoshi Sato, Misaka Kimura
Sedentary/inactive lifestyle leads middle-aged and older adults to metabolic syndrome and frailty. Capsinoids from nonpungent chili pepper cultivar have been reported to reduce body fat mass, promote metabolism, and improve unidentified complaints of chills. Additionally, they have an anti-inflammation effect; therefore, we hypothesized that continuous oral ingestion of capsinoids alleviates age-related inflammation in the brain and improves the physical activity (PA) in middle-aged and older adults. In our double-blind human study, 69 participants (17 male, 52 female; mean age: 74...
January 14, 2020: Nutrients
https://read.qxmd.com/read/31613626/assessment-of-capsaicinoid-and-capsinoid-accumulation-patterns-during-fruit-development-in-three-chili-pepper-genotypes-capsicum-spp-carrying-pun1-and-pamt-alleles-related-to-pungency
#37
JOURNAL ARTICLE
Oreto Fayos, Neftalí Ochoa-Alejo, Octavio Martínez de la Vega, María Savirón, Jesús Orduna, Cristina Mallor, Gerardo F Barbero, Ana Garcés-Claver
Quantification, using an accurate analytical approach, of capsinoids and capsaicinoids was performed on three chili pepper ( Capsicum spp.) genotypes: "Chiltepı́n", "Tampiqueño 74", and "Bhut Jolokia" at various stages of fruit development. The accumulation of capsinoids, in all these peppers started between 10 to 20 days post-anthesis (dpa), increased and reached the highest capsinoid amount at 40 dpa, and then decreased until 60 dpa. Conversely, capsaicinoids could already be determined at 10 dpa in "Bhut Jolokia" and their accumulation pattern was different from that of the capsinoids in this genotype...
November 6, 2019: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/31377620/molecular-basis-and-potential-applications-of-capsaicinoids-and-capsinoids-against-the-elongation-of-etiolated-wheat-triticum-aestivum-l-coleoptiles-in-foods
#38
JOURNAL ARTICLE
Kexian Chen, Ying Qian, Zhen Ge, Hong Chen, Chaowei Qian, Yunyou Li, Zhongxiu Chen
Capsaicinoids and capsinoids from dietary peppers have promising sensory properties and bioactivity, but the molecular basis of their penetration mechanism through cell lipid bilayers and its relationship to their bioavailability as food constituents are still poorly understood. Herein, statistically significant linear and quadratic quantitative structure-activity relationships were constructed to derive the essential structural elements required for their bioactivity against the elongation of etiolated wheat coleoptiles that mainly occurs via penetration...
July 26, 2019: Food Chemistry
https://read.qxmd.com/read/31301122/brown-adipose-tissue-multimodality-evaluation-by-pet-mri-infrared-thermography-and-whole-body-calorimetry-tactical-ii
#39
JOURNAL ARTICLE
Lijuan Sun, Sanjay Verma, Navin Michael, Siew Pang Chan, Jianhua Yan, Suresh Anand Sadananthan, Stefan G Camps, Hui Jen Goh, Priya Govindharajulu, John Totman, David Townsend, Julian Pak-Nam Goh, Lei Sun, Bernhard Otto Boehm, Su Chi Lim, Siew Kwan Sze, Christiani Jeyakumar Henry, Houchun Harry Hu, S Sendhil Velan, Melvin Khee-Shing Leow
OBJECTIVE: This study aimed to compare the associations of positron emission tomography (PET), magnetic resonance (MR), and infrared thermography (IRT) imaging modalities with energy expenditure (EE) after brown adipose tissue (BAT) activation using capsinoid ingestion and cold exposure. METHODS: Twenty participants underwent PET-MR, IRT imaging, and whole-body calorimetry after capsinoid ingestion and cold exposure. Standardized uptake values (SUV) and the fat fraction (FF) of the supraclavicular brown adipose tissue regions were estimated...
July 13, 2019: Obesity
https://read.qxmd.com/read/30896252/the-safety-and-effectiveness-of-commonly-marketed-natural-supplements-for-weight-loss-in-populations-with-obesity-a-critical-review-of-the-literature-from-2006-to-2016
#40
REVIEW
Sean Wharton, Revi Bonder, Aaron Jeffery, Rebecca A G Christensen
Objective: To evaluate the evidence published from 2006 to 2016 on the effectiveness and safety of commonly used natural supplements for weight loss in individuals with obesity. Methods: Amazon and Google were searched for names of mono-agent natural supplements marketed for weight loss and a list of the 10 supplements was created. Google Scholar, Pubmed, Science Direct, and the Cochrane Library were searched for articles that met inclusion. Results: At least one article was published on the effectiveness or safety of bitter orange, capsinoid, carnitine, chromium picolinate, Coleus forskohlii , conjugated linoleic acid, glucomannan, green tea and psyllium for weight loss in populations with obesity from 2006 to 2016...
2020: Critical Reviews in Food Science and Nutrition
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