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https://www.readbyqxmd.com/read/29325170/ecology-of-paracoccidioides-brasiliensis-p-lutzii-and-related-species-infection-in-armadillos-soil-occurrence-and-mycological-aspects
#1
Marluce Francisca Hrycyk, Hans Garcia Garces, Sandra de Moraes Gimenes Bosco, Sílvio Luis de Oliveira, Sílvio Alencar Marques, Eduardo Bagagli
Paracoccidioides brasiliensis and the related species P. americana, P. restrepiensis, P. venezuelensis, and P. lutzii (Ascomycota, Ajellomycetaceae) are the etiological agents of paracoccidoidoimycosis (PCM), one of the most important systemic mycoses in Latin America. They are dimorphic fungi, with a mycelial life cycle in soil and a yeast phase associated with tissues of mammalian hosts. This study aimed to detect Paracoccidioides spp. in armadillo tissues and associated soil samples in three well-defined geographic areas, including the Alta Floresta, an area not only endemic for PCM in the central region of Brazil but also of probable P...
January 6, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29300307/chemical-composition-and-bioactivity-of-essential-oil-from-blepharocalyx-salicifolius
#2
Fabiana Barcelos Furtado, Bruna Cristina Borges, Thaise Lara Teixeira, Hans Garcia Garces, Luiz Domingues de Almeida Junior, Fernanda Cristina Bérgamo Alves, Claudio Vieira da Silva, Ary Fernandes Junior
Natural products represent a source of biologically active molecules that have an important role in drug discovery. The aromatic plant Blepharocalyx salicifolius has a diverse chemical constitution but the biological activities of its essential oils have not been thoroughly investigated. The aims of this paper were to evaluate in vitro cytotoxic, antifungal and antibacterial activities of an essential oil from leaves of B. salicifolius and to identify its main chemical constituents. The essential oil was extracted by steam distillation, chemical composition was determined by gas chromatography/mass spectrometry, and biological activities were performed by a microdilution broth method...
January 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29230201/differential-metabolism-of-a-two-carbon-substrate-by-members-of-the-paracoccidioides-genus
#3
Lilian C Baeza, Fabiana R da Mata, Laurine L Pigosso, Maristela Pereira, Gustavo H M F de Souza, Alexandre S G Coelho, Célia M de Almeida Soares
The genus Paracoccidioides comprises known fungal pathogens of humans and can be isolated from different infection sites. Metabolic peculiarities in different members of the Paracoccidioides led us to perform proteomic studies in the presence of the two-carbon molecule acetate, which predominates in the nutrient-poor environment of the phagosome. To investigate the expression rates of proteins of different members of Paracoccidioides, including one isolate of P. lutzii (Pb01) and three isolates of P. brasiliensis (Pb03, Pb339, and PbEPM83), using sodium acetate as a carbon source, proteins were quantified using label-free and data-independent liquid chromatography-mass spectrometry...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29228322/tlr9-stimulation-induces-increase-in-fungicidal-activity-of-human-dendritic-cells-challenged-with-paracoccidioides-brasiliensis
#4
Ivy Rafacho Vieira, Reginaldo Keller Fernandes, Daniela Ramos Rodrigues, Carolina Mendonça Gorgulho, Ramon Kaneno, Ângela Maria Victoriano Campos Soares
Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends on pattern recognition receptors (PRRs) to which the microorganism will bind in these cells. Regarding this, TLR9 activation, by stimulating the oxidative metabolism, induces increase in microbicidal activity of these cells. Accordingly, we showed that DCs treatment with a TLR9 agonist results in an increase in fungicidal activity of these cells against the fungus Paracoccidioides brasiliensis (Pb), which however, was not associated to higher H2O2 levels...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29159027/a-case-of-paracoccidioidomycosis-due-to-paracoccidioides-lutzii-presenting-sarcoid-like-form
#5
Luiza Sarmento Tatagiba, Luana Bridi Pivatto, Álvaro A Faccini-Martínez, Paulo Mendes Peçanha, Tânia Regina Grão Velloso, Sarah Santos Gonçalves, Anderson Messias Rodrigues, Zoilo Pires Camargo, Aloísio Falqueto
Paracoccidioidomycosis (PCM) is a fungal disease caused by Paracoccidioides spp., which can cause a systemic granulomatous infection with tegumentary and visceral involvement. Sarcoid-like skin lesions are uncommon and can be misdiagnosed due to similarities with other granulomatous diseases. We report a case of a women presenting with erythematous infiltrated plaques on her face that was treated for leprosy and rosacea with no response and was later diagnosed with PCM, presenting positive serology for Paracoccidioides lutzii...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29134119/identification-of-membrane-proteome-of-paracoccidioides-lutzii-and-its-regulation-by-zinc
#6
Juliana Santana de Curcio, Marielle Garcia Silva, Mirelle Garcia Silva Bailão, Sônia Nair Báo, Luciana Casaletti, Alexandre Mello Bailão, Célia Maria de Almeida Soares
Aim: During infection development in the host, Paracoccidioides spp. faces the deprivation of micronutrients, a mechanism called nutritional immunity. This condition induces the remodeling of proteins present in different metabolic pathways. Therefore, we attempted to identify membrane proteins and their regulation by zinc in Paracoccidioides lutzii. Materials & methods: Membranes enriched fraction of yeast cells of P. lutzii were isolated, purified and identified by 2D LC-MS/MS detection and database search...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29110339/role-of-dectin-1-receptor-on-cytokine-production-by-human-monocytes-challenged-with-paracoccidioides-brasiliensis
#7
Alexandre Giannecchini Romagnolo, Juliana Carvalho de Quaglia E Silva, Amanda Manoel Della Coletta, Taiane Priscila Gardizani, Ana Teresa Loyola Martins, Graziela Gorete Romagnoli, Ramon Kaneno, Angela Maria Victoriano de Campos Soares, Julio Defaveri, Luciane Alarcão Dias-Melicio
Fungal recognition by Dectin-1 receptor triggers a series of cellular mechanisms involved in a protective activation of the immune system. In this study we aimed to evaluate the participation of Dectin-1 receptor in the induction of IL-8, TNF-α, IL-12, IL-10 and IL-17A secretion by human monocytes activated with different cytokines, and challenged in vitro with Paracoccidioides brasiliensis (P. brasiliensis). Our results show that monocytes challenged with P. brasiliensis (Pb265) are able to produce IL-12, IL-8, IL-17, IL-10, and TNF-α...
November 6, 2017: Mycoses
https://www.readbyqxmd.com/read/29099934/a-dectin-1-caspase-8-pathway-licenses-canonical-caspase-1-inflammasome-activation-and-il-1%C3%AE-release-in-response-to-a-pathogenic-fungus
#8
Natália Ketelut-Carneiro, Sreya Ghosh, Stuart M Levitz, Katherine A Fitzgerald, João Santana da Silva
Paracoccidioides brasiliensis is equipped with an arsenal of virulence factors that are crucial for causing infection. Our group previously defined the NLRP3 inflammasome as a mediator of P. brasiliensis-induced cell damage recognition, and induction of effective Th1 immune responses. However, deficiency of caspase-1 only partially reduced IL-1β levels. Here we identify an additional pathway for IL-1β production in response to P. brasiliensis infection. P. brasiliensis initiated caspase-8-mediated IL-1β production, an event that was necessary for transcriptional priming and posttranslational processing of pro-IL-1β...
November 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29069246/hypercalcemia-in-children-three-cases-report-with-unusual-clinical-presentations
#9
Bruna Barros Garbim, Larissa D Ávila, Sumara Zuanazi Pinto Rigatto, Kélcia Rosana da Silva Quadros, Vera Maria Santoro Belangero, Rodrigo Bueno de Oliveira
Hypercalcemia is a rare condition in childhood; the most common causes are primary hyperparathyroidism, malignancy, prolonged immobilisation, thyrotoxicosis, thiazide diuretic, supplements containing calcium, milk-alkali syndrome, vitamin D intoxication, infections and idiopathic. We present three cases of severe hypercalcemia of unusual causes in children. The first patient had high fever, poor general condition, weight loss and myalgia. Extensive preliminary investigation did not define the etiology, but a review of medical history revealed prolonged contact with pet bird and a positive serology for Chlamydia confirmed the diagnosis of psittacosis...
April 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29048286/paracoccidioidomycosis-after-highway-construction-rio-de-janeiro-brazil
#10
Antonio C Francesconi do Valle, Priscila Marques de Macedo, Rodrigo Almeida-Paes, Anselmo R Romão, Marcia Dos Santos Lazéra, Bodo Wanke
Transmission of Paracoccidioides spp. fungi to humans is usually related to manipulation of soil. Rural workers are the most affected group. We report an outbreak of paracoccidioidomycosis after deforestation and massive earth removal during construction of a highway in Rio de Janeiro, Brazil. Extensive environmental disturbances might be involved in fungal transmission.
November 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29042530/hypereosinophilia-secondary-to-disseminated-paracoccidioidomycosis
#11
Mateo Mejia-Zuluaga, Samuel Rosas, Verónica Posada Vélez, Pedro A Quintero
BACKGROUND Paracoccidioidomycosis is an endemic mycosis in Central and South America caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. Despite its self-limited course and usually asymptomatic infection, some patients may present with a systemic illness mimicking multiple conditions and thus question the general state of their immune system. CASE REPORT A 28-year-old male presented to the hospital with fever, dry cough, and non-pruritic rash with no characteristic distribution for the past 10 days...
October 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29040281/impaired-anti-fibrotic-effect-of-bone-marrow-derived-mesenchymal-stem-cell-in-a-mouse-model-of-pulmonary-paracoccidioidomycosis
#12
Julián Camilo Arango, Juan David Puerta-Arias, Paula Andrea Pino-Tamayo, Lina María Salazar-Peláez, Mauricio Rojas, Ángel González
Bone marrow-derived mesenchymal stem cells (BMMSCs) have been consider as a promising therapy in fibrotic diseases. Experimental models suggest that BMMSCs may be used as an alternative therapy to treat chemical- or physical-induced pulmonary fibrosis. We investigated the anti-fibrotic potential of BMMSCs in an experimental model of lung fibrosis by infection with Paracoccidioides brasiliensis. BMMSCs were isolated and purified from BALB/c mice using standardized methods. BALB/c male mice were inoculated by intranasal infection of 1...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29018875/human-neutrophils-are-targets-to-paracoccin-a-lectin-expressed-by-paracoccidioides-brasiliensis
#13
R Ricci-Azevedo, R A Gonçales, M C Roque-Barreira, D Girard
OBJECTIVE AND DESIGN: Paracoccin (PCN), a lectin expressed by Paracoccidioides brasiliensis (Pb), is known to exert activities on the fungal biology, as well as different immune cells of myeloid origin. The aim of this study was to investigate the direct interaction of the recombinant form of the lectin (rPCN) with neutrophils, a neglected area. MATERIALS OR SUBJECTS: Freshly isolated human neutrophils from healthy donors were used. TREATMENT: Neutrophils were incubated with rPCN in vitro...
October 10, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28992214/differential-production-of-interleukin-1-family-cytokines-il-1%C3%AE-il-18-il-33-and-il-37-in-patients-with-paracoccidioidomycosis-correlation-with-clinical-form-and-antifungal-therapy
#14
André Bueno Rocha Moreira Alves, Murilo Amato David, Lívia Furquim de Castro, Rosiane Maria da Silva, Larissa Nara Alegrini Longhi, Maria Heloisa de Souza Lima Blotta, Ronei Luciano Mamoni
Besides interleukin (IL)-1β and IL-18, the newly described cytokines of IL-1 family IL-33 and IL-37 can contribute to the differentiation and maintenance of different population of T cells. IL-33 acts as an allarmin and promotes a predominant Th2 inflammatory response, whereas IL-37 plays an important role as an antagonist of inflammation. In paracoccidioidomycosis (PCM), caused by the dimorphic fungi Paracoccidioides brasiliensis and P. lutzii, it has been shown that the acquired immune responses are associated with the diverse clinical manifestations...
July 28, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28970825/involvement-of-dihydrolipoyl-dehydrogenase-in-the-phagocytosis-and-killing-of-paracoccidioides-brasiliensis-by-macrophages
#15
Taise N Landgraf, Marcelo V Costa, Aline F Oliveira, Wander C Ribeiro, Ademilson Panunto-Castelo, Fabrício F Fernandes
Paracoccidioides brasiliensis and Paracoccidioides lutzii are fungi causing paracoccidioidomycosis (PCM), an autochthonous systemic mycosis found in Latin America. These microorganisms contain a multitude of molecules that may be associated with the complex interaction of the fungus with the host. Here, we identify the enzyme dihydrolipoyl dehydrogenase (DLD) as an exoantigen from P. brasiliensis (Pb18_Dld) by mass spectrometry. Interestingly, the DLD gene expression in yeast form showed higher expression levels than those in mycelial form and transitional phases...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28966914/laryngeal-paracoccidioidomycosis-presenting-as-solitary-true-vocal-fold-disease
#16
Walter de Araujo Eyer-Silva, Annelise Callmann Santana, Guilherme Almeida Rosa da Silva, Marcelo Costa Velho Mendes de Azevedo, Juliana Li Ting Matos Sun Barreto, Marina Apolloni Neumann, Izana Junqueira de Castro, Rodrigo Panno Basílio-de-Oliveira, Luciana Ferreira de Araujo, Nathane Zanineli Ré, Felipe Marques de Oliveira, Caio José de Araujo Simas, Marcos André de Sarvat, Fernando Raphael de Almeida Ferry
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis or P. lutzii. It is a neglected tropical infectious disease that poses a major public health burden in endemic areas of Latin America. Mucosae of the upper digestive and respiratory tracts are commonly involved and many patients have disease at multiple mucosal sites, with or without lung involvement. Mucosal PCM presenting as solitary true vocal fold disease is relatively rare. We present the case of a 67-year-old Brazilian forest guard who presented with a 6-month history of hoarseness and globus pharyngeus due to a solitary left true vocal fold infiltration and vegetation diagnosed as PCM...
2017: IDCases
https://www.readbyqxmd.com/read/28954085/case-report-of-myeloperoxidase-deficiency-associated-with-disseminated-paracoccidioidomycosis-and-peritoneal-tuberculosis
#17
Maurício Domingues-Ferreira, Ariel Levy, Noac Chuffi Barros, Dalton Luis Bertolini, Dewton de Moraes Vasconcelos
Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28951317/therapeutic-treatment-with-scfv-plga-nanoparticles-decreases-pulmonary-fungal-load-in-a-murine-model-of-paracoccidioidomycosis
#18
Grasielle Pereira Jannuzzi, Nicole de Araújo Souza, Kátia Sanches Françoso, Roney Henrique Pereira, Raquel Possemozer Santos, Gilberto Hideo Kaihami, José Roberto Fogaça de Almeida, Wagner Luiz Batista, André Corrêa Amaral, Andrea Queiroz Maranhão, Sandro Rogério de Almeida, Karen Spadari Ferreira
Paracoccidioidomycosis (PCM) is a systemic mycosis with lymphatic dissemination that is caused by Paracoccidioides species. Treatment of PCM consists of chemotherapeutics such as itraconazole, trimethoprim, sulfamethoxazole or amphotericin B. However, several studies are aiming to develop therapeutic alternatives for the treatment of fungal infection using new molecules as adjuvants. The single-chain variable fragments (scFv) from an antibody that mimics the main fungal component incorporated within poly(lactide-co-glycolic) acid (PLGA) nanoparticles helped treat the fungal disease...
September 23, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28938005/recombinant-vaccines-of-a-cd4-t-cell-epitope-promote-efficient-control-of-paracoccidioides-brasiliensis-burden-by-restraining-primary-organ-infection
#19
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived particle (VLP) as an antigen carrier. This chimera was administered to mice as a (His)6-purified protein (rPbT) or a replication-deficient human type 5 adenoviral vector (rAdPbT) in an immunoprophylaxis assay...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28903987/heat-shock-proteins-in-histoplasma-and-paracoccidioides
#20
REVIEW
Levi G Cleare, Daniel Zamith-Miranda, Joshua D Nosanchuk
Heat shock proteins (Hsps) are highly conserved biomolecules that are constitutively expressed and generally upregulated in response to various stress conditions (biotic and abiotic). Hsps have diverse functions, categorizations, and classifications. Their adaptive expression in fungi indicates their significance in these diverse species, particularly in dimorphic pathogens. Histoplasma capsulatum and Paracoccidioides species are dimorphic fungi that are the causative agents of histoplasmosis and paracoccidioidomycosis, respectively...
November 2017: Clinical and Vaccine Immunology: CVI
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