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https://www.readbyqxmd.com/read/28523421/serological-evidence-of-infection-by-paracoccidioides-brasiliensis-in-dogs-with-leishmaniasis
#1
Tatiane Ferreira Petroni, Lucas Xavier Bonfietti, Tiago Henrique Zaninelli, Eiko Nakagawa Itano, Mario Augusto Ono
Paracoccidioidomycosis is a systemic mycosis prevalent in Latin American countries, caused by the dimorphic fungi Paracoccidioides brasiliensis and P. lutzii. The habitat of these fungi in nature remains undefined, although it is believed that infection occurs by inhalation of infective propagules present in soil. Sentinel animals, such as dogs, can be valuable epidemiological markers of paracoccidioidomycosis. Taking into account that paracoccidioidomycosis and visceral leishmaniasis may occur in the same area, the objective of this study was to evaluate the occurrence of P...
May 18, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28500805/unusual-otolaryngologic-manifestations-of-paracoccidioidomycosis-a-case-report-and-review-of-literature
#2
Lucas Resende Lucinda, José Fernando Polanski
AbstractParacoccidioidomycosis is a systemic mycosis caused by Paracoccidioides brasiliensis. It occurs more frequently in its chronic form, which particularly affects male adults from rural areas. These patients present with pulmonary involvement and systemic symptoms. Skin and mucosal lesions are rather typical and might suggest the diagnosis. The involvement of the upper airway mucosa is common and the patients usually complain of dysphagia and dysphonia. Nonetheless, in endemic areas, physicians should maintain a high level of suspicion even when faced with some atypical symptoms...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28451399/preliminary-evaluation-of-circulating-micrornas-as-potential-biomarkers-in-paracoccidioidomycosis
#3
Junya De Lacorte Singulani, Julhiany De Fátima Da Silva, Fernanda Patricia Gullo, Marina Célia Costa, Ana Marisa Fusco-Almeida, Francisco Javier Enguita, Maria José Soares Mendes-Giannini
MicroRNAs (miRNAs) are small RNAs (length, 19-24 nucleotides) that regulate gene expression by either mRNA degradation or translational inhibition of proteins. Circulating miRNAs, which are extremely stable and protected from RNAse-mediated degradation in body fluids, have appeared as candidate biomarkers for numerous diseases. However, little is known about circulating miRNAs in fungal infections. Paracoccidioidomycosis (PCM) is caused by the Paracoccidioides species, and is endemic in Central and South America, with predominance in adult male workers from rural areas...
March 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28450854/microbial-disease-spectrum-linked-to-a-novel-il-12r%C3%AE-1-n-terminal-signal-peptide-stop-gain-homozygous-mutation-with-paradoxical-receptor-cell-surface-expression
#4
Thais Louvain de Souza, Regina C de Souza Campos Fernandes, Juliana Azevedo da Silva, Vladimir Gomes Alves Júnior, Adelia Gomes Coelho, Afonso C Souza Faria, Nabia M Moreira Salomão Simão, João T Souto Filho, Caroline Deswarte, Stéphanie Boisson-Dupuis, Dara Torgerson, Jean-Laurent Casanova, Jacinta Bustamante, Enrique Medina-Acosta
Patients with Mendelian Susceptibility to Mycobacterial Diseases (MSMD) exhibit variable vulnerability to infections by mycobacteria and other intramacrophagic bacteria (e.g., Salmonella and Klebsiella) and fungi (e.g., Histoplasma, Candida, Paracoccidioides, Coccidioides, and Cryptococcus). The hallmark of MSMD is the inherited impaired production of interferon gamma (IFN-γ) or the lack of response to it. Mutations in the interleukin (IL)-12 receptor subunit beta 1 (IL12RB1) gene accounts for 38% of cases of MSMD...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28380215/recombinant-60-kda-heat-shock-protein-from-paracoccidioides-brasiliensis-is-it-a-good-antigen-for-serological-diagnosis-of-paracoccidioidomycosis
#5
G Peron, F F Fernandes, T N Landgraf, R Martinez, A Panunto-Castelo
Paracoccidioides brasiliensis and P. lutzii are fungi that cause paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in South America. For serological diagnosis, although 43-kDa glycoprotein (gp43) is regarded as highly specific for PCM, the occurrence of false negative reactions in sera from patients infected with P. lutzii suggests that preparation with only one antigen is not recommended. Heat shock proteins are feasible alternatives as a second antigen because they are often highly immunogenic...
April 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28355221/acute-juvenile-paracoccidioidomycosis-a-9-year-cohort-study-in-the-endemic-area-of-rio-de-janeiro-brazil
#6
Priscila Marques de Macedo, Rodrigo Almeida-Paes, Dayvison Francis Saraiva Freitas, Andréa Gina Varon, Ariane Gomes Paixão, Anselmo Rocha Romão, Ziadir Francisco Coutinho, Claudia Vera Pizzini, Rosely Maria Zancopé-Oliveira, Antonio Carlos Francesconi do Valle
BACKGROUND: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by pathogenic dimorphic fungi of the genus Paracoccidioides. It is the most important systemic mycosis in Latin America and the leading cause of hospitalizations and death among them in Brazil. Acute PCM is less frequent but relevant because vulnerable young patients are affected and the severity is usually higher than that of the chronic type. METHODS: The authors performed a retrospective cohort study from 2001 to 2009 including acute juvenile PCM patients from a reference center in Rio de Janeiro, Brazil...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28349345/photodynamic-inactivation-of-paracoccidioides-brasiliensis-helps-the-outcome-of-oral-paracoccidiodomycosis
#7
Letícia F M Dos Santos, Nathália B Melo, Marina L de Carli, Ana Carolina S C Mendes, Giulia Maria A C Bani, Liana M Verinaud, Eva Burger, Gabriel de Oliveira I Moraes, Alessandro A C Pereira, Maísa R L Brigagão, João Adolfo C Hanemann, Felipe F Sperandio
The antifungal drug therapy often employed to treat paracoccidiodomycosis (PCM), an important neglected fungal systemic infection, leads to offensive adverse effects, besides being very long-lasting. In addition, PCM compromises the oral health of patients by leading to oral lesions that are very painful and disabling. In that way, photodynamic therapy (PDT) arises as a new promising adjuvant treatment for inactivating Paracoccidioides brasiliensis (Pb), the responsible fungus for PCM, and also for helping the patients to deal with such debilitating oral lesions...
March 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28344577/linear-epitopes-of-paracoccidioides-brasiliensis-and-other-fungal-agents-of-human-systemic-mycoses-as-vaccine-candidates
#8
REVIEW
Luiz R Travassos, Carlos P Taborda
Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America; Histoplasma capsulatum, Coccidioides posadasii, and Coccidioides immitis, and the Sporothrix spp. complex are other important pathogens. Associated with dimorphic fungi other important infections are caused by yeast such as Candida spp. and Cryptococcus spp. or mold such as Aspergillus spp...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28339963/anti-apoptotic-effects-of-decyl-gallate-on-the-induction-of-apoptosis-in-a549-pneumocytes-by-paracoccidioides-brasiliensis-gp43
#9
Thais Bernardi, Julhiany de Fátima da Silva, Juliana Vicentin, Haroldo Cesar de Oliveira, Patricia Akemi Assato, Caroline Maria Marcos, Ana Carolina Alves de Paula E Silva, Rosangela Aparecida Moraes da Silva, Luis Octávio Regasini, Dulce Helena Siqueira Silva, Vanderlan da Silva Bolzani, Ana Marisa Fusco-Almeida, Maria José Soares Mendes-Giannini
Apoptosis is considered an escape mechanism from the host immune system for the fungus Paracoccidioides spp, and it serves as a vehicle for entry into macrophages without stimulating microbicidal activities. Recently, gp43 of P. brasiliensis was demonstrated to be involved in this process. Therefore, as a new therapeutic alternative, it is very important to study compounds that could reduce the modulation of the induction of apoptosis caused by this fungus. Decyl gallate (G14) is a known antifungal compound, and we decided to investigate its anti-apoptotic properties...
March 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28337637/in-vivo-paracoccidioides-sp-biofilm-on-vascular-prosthesis
#10
Maria Emilia Cattana, Maria Fernanda Tracogna, Isabel Marques, Florencia Rojas, Mariana Fernández, María de Los Ángeles Sosa, Javier Mussin, Gustavo Giusiano
Paracoccidioidomycosis is an endemic mycosis caused by Paracoccidioides species limited to Latin America arising with the chronic form in 90% of cases. The capacity of microorganisms to form biofilms is considered of great importance medical since can contribute to the persistence and to the chronic state of the diseases. The ability of Paracoccidioides to form biofilm has been demonstrated in vitro. In our study, for the first time we have observed this capability in vivo on a vascular prosthesis using scanning electron microscope showing a dense network of Paracoccidioides yeasts covered by an extracellular matrix...
March 23, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28324244/animal-models-and-antifungal-agents-in-paracoccidioidomycosis-an-overview
#11
REVIEW
Luciano Z Goldani, Fernanda Wirth
Paracoccidioides brasiliensis is the etiologic agent of paracoccidioidomycosis, the most prevalent systemic mycosis in Latin America. The morbidity and mortality associated with paracoccidioidomycosis necessitate our understanding of fungal pathogenesis and discovering of new agents to treat this infection. Animal models have contributed much to the knowledge of fungal infections and their corresponding therapeutic treatments. This is true for animal models of the primary fungal pathogens such as P. brasiliensis...
March 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28295653/paracoccidioidomycosis-infection-in-domestic-and-wild-mammals-by-paracoccidioides-lutzii
#12
Josiara F Mendes, Gabriel B Klafke, Ana Paula N Albano, Ângela L Cabana, Alessandra J Teles, Zoilo P de Camargo, Melissa O Xavier, Mário Carlos A Meireles
Paracoccidioidomycosis (PCM) is a systemic mycosis that occurs in several Latin American countries, especially in Brazil. It is caused by the thermo-dimorphic fungus Paracoccidioides spp. Serological studies to detect animal infection represent an excellent strategy for data on the agent's ecology. Although the state of Rio Grande do Sul (RS) is an endemic area for PCM in humans, there is scarce information available on the ecology of the agent in the region. This study aimed to investigate the infection by Paracoccidioides lutzii in animals living in RS, Brazil...
June 2017: Mycoses
https://www.readbyqxmd.com/read/28279786/miltefosine-is-fungicidal-to-paracoccidioides-spp-yeast-cells-but-subinhibitory-concentrations-induce-melanisation
#13
Diego Conrado Pereira Rossi, Cristina de Castro Spadari, Joshua Daniel Nosanchuk, Carlos Pelleschi Taborda, Kelly Ishida
Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungi Paracoccidioides spp. The duration of antifungal treatment ranges from months to years and relapses may nevertheless occur despite protracted therapy. Thus, there remains an urgent need for new therapeutic options. Miltefosine (MLT), an analogue of alkylphospholipids, has antifungal activity against species of yeast and filamentous fungi. The aim of this study was to evaluate the antifungal effects of MLT on the yeast forms of Paracoccidioides brasiliensis and Paracoccidioides lutzii...
April 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28239394/standardization-and-validation-of-dot-elisa-assay-for-paracoccidioides-brasiliensis-antibody-detection
#14
Camila Mika Kamikawa, Rinaldo Poncio Mendes, Adriana Pardini Vicentini
BACKGROUND: Paracoccidioidomycosis (PCM) is a neglected systemic mycosis caused by a dimorphic fungus of the Paracoccidioides genus. The standard diagnosis is based on isolation of the fungi in culture, and by microscopic visualization of characteristic multiple budding yeast cells in biological samples. However, in some situations, access to the site of injury prevents the collection of biological material. A variety of immuno-serological techniques has proven useful for allowing inferring diagnosis with a certain degree of certainty, thus optimizing time...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28177048/use-of-fluorescent-oligonucleotide-probes-for-differentiation-between-paracoccidioides-brasiliensis-and-paracoccidioides-lutzii-in-yeast-and-mycelial-phase
#15
Thales Domingos Arantes, Raquel Cordeiro Theodoro, Marcus de Melo Teixeira, Eduardo Bagagli
BACKGROUND: Fluorescence in situ hybridisation (FISH) associated with Tyramide Signal Amplification (TSA) using oligonucleotides labeled with non-radioactive fluorophores is a promising technique for detection and differentiation of fungal species in environmental or clinical samples, being suitable for microorganisms which are difficult or even impossible to culture. OBJECTIVE: In this study, we aimed to standardise an in situ hybridisation technique for the differentiation between the pathogenic species Paracoccidioides brasiliensis and Paracoccidioides lutzii, by using species-specific DNA probes targeting the internal transcribed spacer-1 (ITS-1) of the rRNA gene...
February 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28176377/novel-taxa-of-thermally-dimorphic-systemic-pathogens-in-the-ajellomycetaceae-onygenales
#16
Karolina Dukik, Jose F Muñoz, Yanping Jiang, Peiying Feng, Lynne Sigler, J Benjamin Stielow, Joanna Freeke, Azadeh Jamalian, Bert Gerrits van den Ende, Juan G McEwen, Oliver K Clay, Ilan S Schwartz, Nelesh P Govender, Tsidiso G Maphanga, Christina A Cuomo, Leandro F Moreno, Chris Kenyon, Andrew M Borman, Sybren de Hoog
Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species...
May 2017: Mycoses
https://www.readbyqxmd.com/read/28093309/paracoccidioides-spp-catalases-and-their-role-in-antioxidant-defense-against-host-defense-responses
#17
Diana Tamayo, José F Muñoz, Agostinho J Almeida, Juan D Puerta, Ángela Restrepo, Christina A Cuomo, Juan G McEwen, Orville Hernández
Dimorphic human pathogenic fungi interact with host effector cells resisting their microbicidal mechanisms. Yeast cells are able of surviving within the tough environment of the phagolysosome by expressing an antioxidant defense system that provides protection against host-derived reactive oxygen species (ROS). This includes the production of catalases (CATs). Here we identified and analyzed the role of CAT isoforms in Paracoccidioides, the etiological agent of paracoccidioidomycosis. Firstly, we found that one of these isoforms was absent in the closely related dimorphic pathogen Coccidioides and dermatophytes, but all of them were conserved in Paracoccidioides, Histoplasma and Blastomyces species...
March 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/28074055/effects-of-two-6-quinolinyl-chalcones-on-the-integrity-of-plasma-membrane-of-paracoccidioides-brasiliensis
#18
Nívea P de Sá, Patrícia S Cisalpino, Luciana C Tavares, Leandro Espíndola, Beatriz M Borelli, Paulo Js Barbeira, Gabriele de Matos Cardoso Perdigão, Elaine M Souza-Fagundes, Carlos A Rosa, Moacir G Pizzolatti, Susana Johann
Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America, yet few therapeutic options exist. Our aim was to search for new compounds with high efficacy, low toxicity, shorter treatment time and affordable cost. We studied two synthetic 6-quinolinyl chalcones, 3b and 3e, to determine their effects on VERO cells, antifungal activity, survival curve, interaction with other drugs and phenotypic effects against several isolates of Paracoccidioides spp. In this study, we verified that the compounds were not toxic, exhibited superior in vitro activity compared with that shown by trimethoprim-sulfamethoxazole, and after 5 days of treatment, decreased the fungal cell viability by approximately 70%...
March 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28053145/study-of-differential-expression-of-mirnas-in-lung-tissue-of-mice-submitted-to-experimental-infection-by-paracoccidioides-brasiliensis
#19
Denise Turini Gonzales Marioto, Ana Carolina Navarro Dos Santos Ferraro, Fábio Goulart de Andrade, Marília Barros Oliveira, Eiko Nakagawa Itano, Silvana Petrofeza, Emerson José Venancio
MicroRNAs (miRNAs) are small single stranded RNA sequences involved in post-transcriptional regulation of different biological and physiological processes. Paracoccidioidomycosis (PCM) is an infection caused by Paracoccidioides brasiliensis, and it is a major cause of mortality due to systemic mycoses in Brazil. To date, there have been few reports on the role of miRNAs in the immune response against fungi, especially PCM. The objective of this study was to evaluate the differential expression of miRNAs related to the inflammatory response associated with pulmonary infection by P...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28039947/acute-pulmonary-involvement-by-paracoccidiodomycosis-disease-immediately-after-kidney-transplantation-case-report-and-literature-review
#20
Marcelo V Radisic, Laura Linares, Javier Afeltra, Natalia Pujato, Roxana G Vitale, Martin Bravo, Ana C Dotta, Domingo H Casadei
Paracoccidioides brasiliensis is the cause of paracoccidioidomycosis, one of the most important systemic mycoses in Latin America. Human disease has been observed in a limited geographic and ecological niche, and it is attributed to exposure to the fungus in soil. Most primary infections are subclinical, as the infection is contained by the host mainly through cell-mediated immune response. However, as the fungus has the ability to survive in a dormant state for long periods, an impairment of the immune response may lead to reactivation and clinical disease...
December 31, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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