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Suzanne Cadarette

Natasha Nanwa, Beate Sander, Murray Krahn, Nick Daneman, Hong Lu, Peter C Austin, Anand Govindarajan, Laura C Rosella, Suzanne M Cadarette, Jeffrey C Kwong
Few studies have evaluated the mortality or quantified the economic burden of community-onset Clostridium difficile infection (CDI). We estimated the attributable mortality and costs of community-onset CDI. We conducted a population-based matched cohort study. We identified incident subjects with community-onset CDI using health administrative data (emergency department visits and hospital admissions) in Ontario, Canada between January 1, 2003 and December 31, 2010. We propensity-score matched each infected subject to one uninfected subject and followed subjects in the cohort until December 31, 2011...
2017: PloS One
Suzanne M Cadarette, Joann K Ban, Giulia P Consiglio, Cody D Black, David Dubins, Alexandra Marin, Mina Tadrous
OBJECTIVE: The objective of this study was to characterize the diffusion of methodological innovation. STUDY DESIGN AND SETTING: Comparative case study analysis of the diffusion of two methods that summarize confounder information into a single score: disease risk score (DRS) and high-dimensional propensity score (hdPS). We completed systematic searches to identify DRS and hdPS papers in the field of pharmacoepidemiology through to the end of 2013, plotted the number of papers and unique authors over time, and created sociograms and animations to visualize co-authorship networks...
December 23, 2016: Journal of Clinical Epidemiology
Petros Pechlivanoglou, Lusine Abrahamyan, Linda MacKeigan, Giulia P Consiglio, Lisa Dolovich, Ping Li, Suzanne M Cadarette, Valeria E Rac, Jonghyun Shin, Murray Krahn
BACKGROUND: Medication reviews have become part of pharmacy practice across developed countries. This study aimed to identify factors affecting the likelihood of eligible Ontario seniors receiving a pharmacy-led medication review called MedsCheck annual (MCA). METHODS: We designed a cohort study using a random sample of pharmacy claims for MCA-eligible Ontario seniors using linked administrative data from April 2012 to March 2013. Guided by a conceptual framework, we constructed a generalized-estimating-equations model to estimate the effect of patient, pharmacy and community factors on the likelihood of receiving MCA...
November 21, 2016: BMC Health Services Research
Lisa Dolovich, Giulia Consiglio, Linda MacKeigan, Lusine Abrahamyan, Petros Pechlivanoglou, Valeria E Rac, Nedzad Pojskic, Elizabeth A Bojarski, Jiandong Su, Murray Krahn, Suzanne M Cadarette
BACKGROUND: MedsCheck Annual (MCA) is an Ontario government-funded medication review service for individuals taking 3 or more prescription medications for chronic conditions. METHODS: This cohort study analyzed linked administrative claims data from April 1, 2007, to March 31, 2013. Trends in MCA claims and recipient characteristics were examined. RESULTS: A total of 1,498,440 Ontarians (55% seniors, 55% female) received an MCA. One-third (36%) had 2 or more MCAs within 6 years...
September 2016: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
Natasha Nanwa, Jeffrey C Kwong, Murray Krahn, Nick Daneman, Hong Lu, Peter C Austin, Anand Govindarajan, Laura C Rosella, Suzanne M Cadarette, Beate Sander
BACKGROUND High-quality cost estimates for hospital-acquired Clostridium difficile infection (CDI) are vital evidence for healthcare policy and decision-making. OBJECTIVE To evaluate the costs attributable to hospital-acquired CDI from the healthcare payer perspective. METHODS We conducted a population-based propensity-score matched cohort study of incident hospitalized subjects diagnosed with CDI (those with the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Canada code A04...
September 2016: Infection Control and Hospital Epidemiology
Racquel Jandoc, Muhammad Mamdani, Linda E Lévesque, Suzanne M Cadarette
UNLABELLED: We identified significantly slower uptake, and consistently lower proportions of new oral bisphosphonate formulations dispensed in rural regions compared to urban regions of Ontario. Further research examining regional differences in outcomes may provide insight as to whether urban-rural differences in prescribing translate into health disparities between regions. PURPOSE: The aim of this study was to examine urban-rural differences in the uptake of new oral bisphosphonate formulations available on the Ontario drug formulary: alendronate + vitamin D3 (January 2007), monthly risedronate (June 2009), and risedronate delayed-release (February 2012)...
2016: Archives of Osteoporosis
Mina Tadrous, Muhammad M Mamdani, David N Juurlink, Murray D Krahn, Linda E Lévesque, Suzanne M Cadarette
AIM: To examine the performance of the disease risk score (DRS) in a cohort study with evidence of policy-induced selection bias. METHODS: We examined two cohorts of new users of bisphosphonates. Estimates for 1-year hip fracture rates between agents using DRS, exposure propensity scores and traditional multivariable analysis were compared. RESULTS: The results for the cohort with no evidence of policy-induced selection bias showed little variation across analyses (-4...
November 2015: Journal of Comparative Effectiveness Research
Suzanne M Cadarette, Lindsay Wong
No abstract text is available yet for this article.
May 2015: Canadian Journal of Hospital Pharmacy
Racquel Jandoc, Nathaniel Jembere, Saba Khan, Storm J Russell, Yvon Allard, Suzanne M Cadarette
UNLABELLED: Half of Métis citizens, compared to less than 10 % of the general population of Ontario, reside in northern regions, with little access to bone mineral density (BMD) testing. Métis citizens had lower sex-specific and age-standardized rates of BMD testing, yet similar rates of fracture (both sexes) and pharmacotherapy (women only). PURPOSE: To examine osteoporosis management and common osteoporosis-related fractures among Métis citizens compared to the general population of older adults residing in Ontario...
2015: Archives of Osteoporosis
Racquel Jandoc, Andrea M Burden, Muhammad Mamdani, Linda E Lévesque, Suzanne M Cadarette
OBJECTIVES: To describe the use and reporting of interrupted time series methods in drug utilization research. STUDY DESIGN AND SETTING: We completed a systematic search of MEDLINE, Web of Science, and reference lists to identify English language articles through to December 2013 that used interrupted time series methods in drug utilization research. We tabulated the number of studies by publication year and summarized methodological detail. RESULTS: We identified 220 eligible empirical applications since 1984...
August 2015: Journal of Clinical Epidemiology
Natasha Nanwa, Tetyana Kendzerska, Murray Krahn, Jeffrey C Kwong, Nick Daneman, William Witteman, Nicole Mittmann, Suzanne M Cadarette, Laura Rosella, Beate Sander
OBJECTIVES: With Clostridium difficile infection (CDI) on the rise, knowledge of the current economic burden of CDI can inform decisions on interventions related to CDI. We systematically reviewed CDI cost-of-illness (COI) studies. METHODS: We performed literature searches in six databases: MEDLINE, Embase, the Health Technology Assessment Database, the National Health Service Economic Evaluation Database, the Cost-Effectiveness Analysis Registry, and EconLit. We also searched gray literature and conducted reference list searches...
April 2015: American Journal of Gastroenterology
Lisa-Ann Fraser, Jordan M Albaum, Mina Tadrous, Andrea M Burden, Salimah Z Shariff, Suzanne M Cadarette
BACKGROUND: Bisphosphonates are the first-line therapy for the treatment of osteoporosis. In the province of Ontario, the Ontario Drug Benefit Program funds medications for patients aged 65 years and older. The Ontario Drug Benefit Program has a generic substitution policy that requires lower-cost generic drugs to be dispensed when they are available. However, there is controversy surrounding the efficacy and tolerability of generic bisphosphonates. The objective of this study was to describe patterns in the use of brand-name versus generic formulations when dispensing oral bisphosphonate over a 13-year period...
January 2015: CMAJ Open
Jordan M Albaum, Soyoung Youn, Linda E Levesque, Andrea S Gershon, Suzanne M Cadarette
BACKGROUND: Clinical practice guidelines recommend that all patients starting chronic oral glucocorticoid (GC) therapy receive bone mineral density (BMD) testing and osteoporosis pharmacotherapy. OBJECTIVE: We completed a systematic review of observational studies to examine the proportion of patients on chronic oral GC therapy who receive osteoporosis management. METHODS: Two independent reviewers completed a systematic search of Ovid MEDLINE® and EMBASE® to identify all English language articles that examined the prevalence of osteoporosis management among chronic oral GC users...
2014: Journal of Population Therapeutics and Clinical Pharmacology
Andrea M Burden, J Michael Paterson, Andrea Gruneir, Suzanne M Cadarette
PURPOSE: Days supply (prescription duration) values are commonly used to estimate drug exposure and quantify adherence to therapy, yet accuracy is not routinely assessed, and potential inaccurate reporting has been previously identified. We examined the impact of cleaning days supply values on the measurement of adherence to oral bisphosphonates. METHODS: We identified new users of oral bisphosphonates among Ontario seniors (April 2001-March 2011). Days supply values were examined by dose, and we identified misclassification by comparing observed values to dose-specific expected values...
January 2015: Pharmacoepidemiology and Drug Safety
Suzanne M Cadarette, Linda Lévesque, Muhammad Mamdani, Sylvie Perreault, David N Juurlink, J Michael Paterson, Greg Carney, Nadia Gunraj, Gillian A Hawker, Mina Tadrous, Lindsay Wong, Colin R Dormuth
BACKGROUND: Orally administered bisphosphonate drugs (i.e., alendronate, etidronate, risedronate) can reduce the risk of vertebral fracture. However, only alendronate and risedronate have proven efficacy in reducing the risk of hip fracture. We sought to examine the comparative effectiveness of orally administered bisphosphonate drugs in reducing hip fractures among older adults. METHODS: We identified new users of orally administered bisphosphonate drugs in British Columbia and Ontario between 2001 and 2008...
September 2013: CMAJ Open
Kyla L Naylor, Eric McArthur, William D Leslie, Lisa-Ann Fraser, Sophie A Jamal, Suzanne M Cadarette, Jennie G Pouget, Charmaine E Lok, Anthony B Hodsman, Jonathan D Adachi, Amit X Garg
Knowing a person's fracture risk according to their kidney function, gender, and age may influence clinical management and decision-making. Using healthcare databases from Ontario, Canada, we conducted a cohort study of 679,114 adults of 40 years and over (mean age 62 years) stratified at cohort entry by estimated glomerular filtration rate ((eGFR) 60 and over, 45-59, 30-44, 15-29, and under 15 ml/min per 1.73 m(2)), gender, and age (40-65 and over 65 years). The primary outcome was the 3-year cumulative incidence of fracture (proportion of adults who fractured (hip, forearm, pelvis, or proximal humerus) at least once within 3-years of follow-up)...
October 2014: Kidney International
Giulia P Consiglio, Andrea M Burden, Malcolm Maclure, Lisa McCarthy, Suzanne M Cadarette
PURPOSE: The purpose of this study is to systematically identify and review articles that use the case-crossover study design in the area of pharmacoepidemiology. METHODS: A systematic search of MEDLINE® (Ovid Technologies, New York City, NY, USA), EMBASE® (Elsevier Inc., Philadelphia, PA, USA), and Web of Science® (Thomson Reuters, New York City, NY, USA) was completed to identify all English language articles that applied the case-crossover study design in the area of pharmacoepidemiology...
November 2013: Pharmacoepidemiology and Drug Safety
Andrea M Burden, Anjie Huang, Mina Tadrous, Suzanne M Cadarette
UNLABELLED: We examined pharmacy claims for osteoporosis medications dispensed in the community (78 %) and long-term care (LTC) to determine if days supply values matched expected dosing intervals. Results identify potential reporting errors that can have implications for drug exposure misclassification, particularly in LTC where only 59 % of reported values matched expected values. INTRODUCTION: The days supply field is commonly used to examine patterns of drug utilization and classify drug exposure, yet its accuracy has received little attention...
2013: Archives of Osteoporosis
Mina Tadrous, Joshua J Gagne, Til Stürmer, Suzanne M Cadarette
PURPOSE: To systematically examine trends and applications of the disease risk score (DRS) as a confounder summary method. METHODS: We completed a systematic search of MEDLINE and Web of Science® to identify all English language articles that applied DRS methods. We tabulated the number of publications by year and type (empirical application, methodological contribution, or review paper) and summarized methods used in empirical applications overall and by publication year (<2000, ≥2000)...
February 2013: Pharmacoepidemiology and Drug Safety
Andrew W Y Shih, Matthew A Weir, Kristin K Clemens, Zhan Yao, Tara Gomes, Muhammad M Mamdani, David N Juurlink, Amanda Hird, Anthony Hodsman, Chirag R Parikh, Ron Wald, Suzanne M Cadarette, Amit X Garg
Intravenous bisphosphonates can cause acute kidney injury; however, this risk was not found with oral bisphosphonates in randomized clinical trials with restrictive eligibility criteria. In order to provide complementary safety data, we studied the risk of acute kidney injury in a population-based cohort of 122,727 patients aged 66 years and older discharged from hospital following a new fragility fracture and no history of bisphosphonate use in the prior year. Bisphosphonate treatment was identified within 120 days after discharge and event rates were measured from 90 days of therapy initiation...
October 2012: Kidney International
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