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https://www.readbyqxmd.com/read/27931190/daily-rhythmicity-of-clock-gene-transcript-levels-in-fast-and-slow-muscle-fibers-from-chinese-perch-siniperca-chuatsi
#1
Ping Wu, Yu-Long Li, Jia Cheng, Lin Chen, Xin Zhu, Zhi-Guo Feng, Jian-She Zhang, Wu-Ying Chu
BACKGROUND: Clock genes are considered to be the molecular core of biological clock in vertebrates and they are directly involved in the regulation of daily rhythms in vertebrate tissues such as skeletal muscles. Fish myotomes are composed of anatomically segregated fast and slow muscle fibers that possess different metabolic and contractile properties. To date, there is no report on the characterization of the circadian clock system components of slow muscles in fish. RESULTS: In the present study, the molecular clock components (clock, arntl1/2, cry1/2/3, cry-dash, npas2, nr1d1/2, per1/2/3, rorα and tim genes) and their daily transcription levels were characterized in slow and fast muscles of Chinese perch (Siniperca chuatsi)...
December 8, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27920997/cyclic-variation-of-cellular-clock-proteins-in-the-mouse-estrous-ovary
#2
George Wiggins, Michael Legge
BACKGROUND: The mammalian ovary is controlled by a number of biological rhythms, which regulate the recruitment and release of mature oocytes. The main objective of this study was to investigate the role of cellular clock proteins during follicle maturation in the mouse estrous ovary. METHODS: Immunohistochemical (IHC) studies were performed on ovaries from 50 estrous staged mice culled at two time points of 09:00 [day] and 01:00 [mid-point of the dark cycle]. Six antibodies were used to identify the expression of core cellular clock proteins (BMAL1, CLOCK, CRY1, CRY2, PER1 and PER2) within the ovary and four follicle stages, primordial, primary, antral and corpus lutea...
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27907092/unconjugated-bile-acids-influence-expression-of-circadian-genes-a-potential-mechanism-for-microbe-host-crosstalk
#3
Kalaimathi Govindarajan, John MacSharry, Patrick G Casey, Fergus Shanahan, Susan A Joyce, Cormac G M Gahan
Disruptions to circadian rhythm in mice and humans have been associated with an increased risk of obesity and metabolic syndrome. The gut microbiota is known to be essential for the maintenance of circadian rhythm in the host suggesting a role for microbe-host interactions in the regulation of the peripheral circadian clock. Previous work suggested a role for gut bacterial bile salt hydrolase (BSH) activity in the regulation of host circadian gene expression. Here we demonstrate that unconjugated bile acids, known to be generated through the BSH activity of the gut microbiota, are potentially chronobiological regulators of host circadian gene expression...
2016: PloS One
https://www.readbyqxmd.com/read/27893733/adarb1-catalyzes-circadian-a-to-i-editing-and-regulates-rna-rhythm
#4
Hideki Terajima, Hikari Yoshitane, Haruka Ozaki, Yutaka Suzuki, Shigeki Shimba, Shinya Kuroda, Wataru Iwasaki, Yoshitaka Fukada
It has been proposed that the CLOCK-ARNTL (BMAL1) complex drives circadian transcription of thousands of genes, including Per and Cry family genes that encode suppressors of CLOCK-ARNTL-dependent transcription. However, recent studies demonstrated that 70-80% of circadian-oscillating mRNAs have no obvious rhythms in their de novo transcription, indicating the potential importance of post-transcriptional regulation. Our CLOCK-ChIP-seq analysis identified rhythmic expression of adenosine deaminase, RNA-specific, B1 (Adarb1, also known as Adar2), an adenosine-to-inosine (A-to-I) RNA-editing enzyme...
November 28, 2016: Nature Genetics
https://www.readbyqxmd.com/read/27864230/the-circadian-clock-protein-cry2-promotes-myc-degradation
#5
(no author information available yet)
CRY2 recruits SCF(FBXL3) to ubiquitinate MYC, promoting MYC degradation and preventing transformation.
November 18, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27858334/identification-of-medaka-magnetoreceptor-and-cryptochromes
#6
Yunzhi Wang, Jianbin Chen, Feng Zhu, Yunhan Hong
Magnetoreception is a hallmark ability of animals for orientation and migration via sensing and utilizing geomagnetic fields. Magnetoreceptor (MagR) and cryptochromes (Cry) have recently been identified as the basis for magnetoreception in Drosophila. However, it has remained unknown whether MagR and Cry have conserved roles in diverse animals. Here we report the identification and expression of magr and cry genes in the fish medaka (Oryzias latipes). Cloning and sequencing identified a single magr gene, four cry genes and one cry-like gene in medaka...
November 17, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27846570/photoactivation-and-inactivation-of-arabidopsis-cryptochrome-2
#7
Qin Wang, Zecheng Zuo, Xu Wang, Lianfeng Gu, Takeshi Yoshizumi, Zhaohe Yang, Liang Yang, Qing Liu, Wei Liu, Yun-Jeong Han, Jeong-Il Kim, Bin Liu, James A Wohlschlegel, Minami Matsui, Yoshito Oka, Chentao Lin
Cryptochromes are blue-light receptors that regulate development and the circadian clock in plants and animals. We found that Arabidopsis cryptochrome 2 (CRY2) undergoes blue light-dependent homodimerization to become physiologically active. We identified BIC1 (blue-light inhibitor of cryptochromes 1) as an inhibitor of plant cryptochromes that binds to CRY2 to suppress the blue light-dependent dimerization, photobody formation, phosphorylation, degradation, and physiological activities of CRY2. We hypothesize that regulated dimerization governs homeostasis of the active cryptochromes in plants and other evolutionary lineages...
October 21, 2016: Science
https://www.readbyqxmd.com/read/27805417/prevalence-of-cry2-type-genes-in-bacillus-thuringiensis-isolates-recovered-from-diverse-habitats-in-india-and-isolation-of-a-novel-cry2af2-gene-toxic-to-helicoverpa-armigera-cotton-boll-worm
#8
Jawahar Lal Katara, Sarvjeet Kaur, Gouthami Krishna Kumari, Nagendra Kumar Singh
Insecticidal cry and vip genes from Bacillus thuringiensis (Bt) have been used for control of lepidopteran insects in transgenic crops. However, novel genes are required for gene pyramiding to delay evolution of resistance to the currently deployed genes. Two PCR-based techniques were employed for screening of cry2-type genes in 129 Bt isolates from diverse habitats in India and 27 known Bt strains. cry2Ab-type genes were more prevalent than cry2Aa- and cry2Ac-type genes. Correlation between source of isolates and abundance of cry2-type genes was not observed...
December 2016: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/27753938/os-06-03-diurnal-blood-pressure-rhythmicity-in-relation-to-environmental-and-genetic-cues
#9
Chang-Sheng Sheng, Yi-Bang Cheng, Fang-Fei Wei, Wen-Yi Yang, Qian-Hui Guo, Fei-Ka Li, Qi-Fang Huang, Lutgarde Thijs, Yan Li, Jan A Staessen, Ji-Guang Wang
OBJECTIVE: No previous study addressed the relative contributions of environmental and genetic cues to the diurnal blood pressure rhythmicity. We firstly investigated the explained variance of environmental and clock genes in relation to the night-to-day ratio (NDR) and morning surge (MS), respectively. DESIGN AND METHOD: From 24-h ambulatory recordings of systolic blood pressure (SBP) obtained in untreated Chinese patients (51% women; mean age, 51 years), we computed NDR in 897 and MS in 637...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27721187/prkcdbp-cavin3-and-cry2-associate-with-major-depressive-disorder
#10
Leena Kovanen, Kati Donner, Mari Kaunisto, Timo Partonen
BACKGROUND: Dysfunctions in the intrinsic clocks are suggested in patients with depressive disorders. The cryptochrome circadian clocks 1 and 2 (CRY1 and CRY2) proteins modulate circadian rhythms in a cell and influence emotional reactions and mood in an individual. The protein kinase C delta binding protein (PRKCDBP, or CAVIN3), similar to the serum deprivation response protein (SDPR, or CAVIN2), reduces metabolic stability of the PER2-CRY2 transcription factor complex that plays a role in the circadian rhythm synchronization...
September 28, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27697903/reversible-optogenetic-control-of-kinase-activity-during-differentiation-and-embryonic-development
#11
Vishnu V Krishnamurthy, John S Khamo, Wenyan Mei, Aurora J Turgeon, Humza M Ashraf, Payel Mondal, Dil B Patel, Noah Risner, Ellen E Cho, Jing Yang, Kai Zhang
A limited number of signaling pathways are repeatedly used to regulate a wide variety of processes during development and differentiation. Lack of tools to dynamically manipulate signaling pathways in space and time has been a major technical challenge for biologists. Optogenetic techniques, which utilize light to control protein functions in a reversible fashion, hold promise in modulating intracellular signaling networks with high spatial and temporal resolution. Applications of the optogenetics in multicellular organisms, however, have not been widely reported...
October 3, 2016: Development
https://www.readbyqxmd.com/read/27643333/os-06-03-diurnal-blood-pressure-rhythmicity-in-relation-to-environmental-and-genetic-cues
#12
Chang-Sheng Sheng, Yi-Bang Cheng, Fang-Fei Wei, Wen-Yi Yang, Qian-Hui Guo, Fei-Ka Li, Qi-Fang Huang, Lutgarde Thijs, Yan Li, Jan A Staessen, Ji-Guang Wang
OBJECTIVE: No previous study addressed the relative contributions of environmental and genetic cues to the diurnal blood pressure rhythmicity. We firstly investigated the explained variance of environmental and clock genes in relation to the night-to-day ratio (NDR) and morning surge (MS), respectively. DESIGN AND METHOD: From 24-h ambulatory recordings of systolic blood pressure (SBP) obtained in untreated Chinese patients (51% women; mean age, 51 years), we computed NDR in 897 and MS in 637...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27614751/identification-of-zebrafish-magnetoreceptor-and-cryptochrome-homologs
#13
Zuoqiong Zhou, Xiyang Peng, Jianbin Chen, Xiushan Wu, Yuequn Wang, Yunhan Hong
Magnetoreception is essential for magnetic orientation in animal migration. The molecular basis for magnetoreception has recently been elucidated in fruitfly as complexes between the magnetic receptor magnetoreceptor (MagR) and its ligand cryptochrome (Cry). MagR and Cry are present in the animal kingdom. However, it is unknown whether they perform a conserved role in diverse animals. Here we report the identification and expression of zebrafish MagR and Cry homologs towards understanding their roles in lower vertebrates...
September 6, 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27611874/blue-light-perception-by-both-roots-and-rhizobia-inhibits-nodule-formation-in-lotus-japonicus
#14
Aya Shimomura, Ayumi Naka, Nobuyuki Miyazaki, Sayaka Moriuchi, Susumu Arima, Shusei Sato, Hideki Hirakawa, Makoto Hayashi, Maskit Maymon, Ann M Hirsch, Akihiro Suzuki
In many legumes, roots that are exposed to light do not form nodules. Here, we report that blue light inhibits nodulation in Lotus japonicus roots inoculated with Mesorhizobium loti. Using RNA interference, we suppressed the expression of phototropin and cryptochrome genes in L. japonicus hairy roots. Under blue light, plants transformed with an empty vector did not develop nodules, whereas plants exhibiting suppressed expression of cry1 and cry2 genes formed nodules. We also measured rhizobial growth to investigate whether the inhibition of nodulation could be caused by a reduced population of rhizobia in response to light...
September 9, 2016: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/27602964/the-clock-gene-per1-plays-an-important-role-in-regulating-the-clock-gene-network-in-human-oral-squamous-cell-carcinoma-cells
#15
Qin Zhao, Gang Zheng, Kai Yang, Yi-Ran Ao, Xiao-Li Su, Yu Li, Xiao-Qiang Lv
The various clock genes in normal cells, through their interaction, establish a number of positive and negative feedback loops that compose a network structure. These genes play an important role in regulating normal physiological activities. The expression of clock gene PER1 is decreased in many types of cancer. PER1 is highly correlated with the initiation and progression of cancer by regulating numerous downstream genes. However, it is still unclear whether the lower expression of PER1 in cancer can influence the expression of other clock genes in the clock gene network...
September 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27598690/gibberellins-are-involved-in-effect-of-near-null-magnetic-field-on-arabidopsis-flowering
#16
Chunxiao Xu, Yang Yu, Yuxia Zhang, Yue Li, Shufeng Wei
We previously found that flowering of Arabidopsis was suppressed by near-null magnetic field, which was related to the modification of cryptochrome. To disclose the physiological mechanism of this effect, we detected gibberellin (GA) levels and expressions of GA biosynthetic and signaling genes in wild type Arabidopsis plants and cryptochrome double mutant, cry1/cry2, grown in near-null magnetic field. We found that levels of GA4 , GA9 , GA34 , and GA51 in wild type plants in near-null magnetic field were significantly decreased compared with local geomagnetic field controls...
September 6, 2016: Bioelectromagnetics
https://www.readbyqxmd.com/read/27529127/a-cryptochrome-2-mutation-yields-advanced-sleep-phase-in-humans
#17
Arisa Hirano, Guangsen Shi, Christopher R Jones, Anna Lipzen, Len A Pennacchio, Ying Xu, William C Hallows, Thomas McMahon, Maya Yamazaki, Louis J Ptáček, Ying-Hui Fu
Familial Advanced Sleep Phase (FASP) is a heritable human sleep phenotype characterized by very early sleep and wake times. We identified a missense mutation in the human Cryptochrome 2 (CRY2) gene that co-segregates with FASP in one family. The mutation leads to replacement of an alanine residue at position 260 with a threonine (A260T). In mice, the CRY2 mutation causes a shortened circadian period and reduced phase-shift to early-night light pulse associated with phase-advanced behavioral rhythms in the light-dark cycle...
2016: ELife
https://www.readbyqxmd.com/read/27516416/the-blue-light-dependent-polyubiquitination-and-degradation-of-arabidopsis-cryptochrome2-requires-multiple-e3-ubiquitin-ligases
#18
Qing Liu, Qin Wang, Bin Liu, Wei Wang, Xu Wang, Joon Park, Zhenming Yang, Xinglin Du, Mingdi Bian, Chentao Lin
Cryptochromes are blue light receptors regulated by light-dependent ubiquitination and degradation in both plant and animal lineages. The Arabidopsis genome encodes two cryptochromes, CRY1 and CRY2, of which CRY2 undergoes blue light-dependent ubiquitination and 26S proteasome-dependent degradation. The molecular mechanism regulating blue light-dependent proteolysis of CRY2 is still not fully understood. We found that the F-box proteins ZEITLUPE (ZTL) and Lov Kelch Protein2 (LKP2), which mediate blue light suppression of degradation of the CRY2 signaling partner CIB1, are not required for the blue light-dependent CRY2 degradation...
October 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/27492458/disruption-of-clock-gene-expression-in-human-colorectal-liver-metastases
#19
Sander A Huisman, Ali R Ahmadi, Jan N M IJzermans, Cees Verhoef, Gijsbertus T J van der Horst, Ron W F de Bruin
The circadian timing system controls about 40 % of the transcriptome and is important in the regulation of a wide variety of biological processes including metabolic and proliferative functions. Disruption of the circadian clock could have significant effect on human health and has an important role in the development of cancer. Here, we compared the expression levels of core clock genes in primary colorectal cancer (CRC), colorectal liver metastases (CRLM), and liver tissue within the same patient. Surgical specimens of 15 untreated patients with primary CRC and metachronous CRLM were studied...
October 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27446119/kinetic-modeling-of-the-arabidopsis-cryptochrome-photocycle-fadh-o-accumulation-correlates-with-biological-activity
#20
Maria Procopio, Justin Link, Dorothy Engle, Jacques Witczak, Thorsten Ritz, Margaret Ahmad
Cryptochromes are flavoprotein photoreceptors with multiple signaling roles during plant de-etiolation and development. Arabidopsis cryptochromes (cry1 and cry2) absorb light through an oxidized flavin (FADox) cofactor which undergoes reduction to both FADH° and FADH(-) redox states. Since the FADH° redox state has been linked to biological activity, it is important to estimate its concentration formed upon illumination in vivo. Here we model the photocycle of isolated cry1 and cry2 proteins with a three-state kinetic model...
2016: Frontiers in Plant Science
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