keyword
MENU ▼
Read by QxMD icon Read
search

CRY2

keyword
https://www.readbyqxmd.com/read/29625018/sugar-sensor-genes-in-the-murine-gastrointestinal-tract-display-a-cephalocaudal-axis-of-expression-and-a-diurnal-rhythm
#1
Patrick O'Brien, Rhys Hewett, Christopher Corpe
Distributed along the length of the gastrointestinal (GI) tract are nutrient sensing cells that release numerous signalling peptides influencing GI function, nutrient homeostasis and energy balance. Recent studies have shown a diurnal rhythm in GI nutrient sensing, but the mechanisms responsible for rhythmicity are poorly understood. In this report we studied murine GI sugar sensor gene and protein expression levels in the morning (7am) and evening (7pm). Sweet taste receptor (tas1r2/tas1r3/gnat3/ gnat1) sugar transporter (slc5a1, slc2a2, slc2a5) and putative sugar sensor (slc5a4a and slc5a4b) gene expression levels were highest in tongue, proximal and distal small intestine, respectively...
April 6, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29614896/modeling-strengthens-molecular-link-between-circadian-polymorphisms-and-major-mood-disorders
#2
Amanda R Liberman, Lumbardh Halitjaha, Ahmet Ay, Krista K Ingram
Anxiety and other mood disorders, such as major depressive disorder (MDD) and seasonal affective disorder (SAD), affect nearly one-fifth of the global population and disproportionately affect young adults. Individuals affected by mood disorders are frequently plagued by sleep and circadian problems, and recent genetic studies provide ample support for the association of circadian and sleep syndromes with depression and anxiety. Mathematical modeling has been crucial in understanding some of the essential features of the mammalian circadian clock and is now a vital tool for dissecting how circadian genes regulate the molecular mechanisms that influence mood...
April 1, 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29610316/long-term-in-vivo-recording-of-circadian-rhythms-in-brains-of-freely-moving-mice
#3
Long Mei, Yanyan Fan, Xiaohua Lv, David K Welsh, Cheng Zhan, Eric Erquan Zhang
Endogenous circadian clocks control 24-h physiological and behavioral rhythms in mammals. Here, we report a real-time in vivo fluorescence recording system that enables long-term monitoring of circadian rhythms in the brains of freely moving mice. With a designed reporter of circadian clock gene expression, we tracked robust Cry1 transcription reporter rhythms in the suprachiasmatic nucleus (SCN) of WT, Cry1 -/- , and Cry2 -/- mice in LD (12 h light, 12 h dark) and DD (constant darkness) conditions and verified that signals remained stable for over 6 mo...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29593090/expression-patterns-of-cryptochrome-genes-in-avian-retina-suggest-involvement-of-cry4-in-light-dependent-magnetoreception
#4
Atticus Pinzon-Rodriguez, Staffan Bensch, Rachel Muheim
The light-dependent magnetic compass of birds provides orientation information about the spatial alignment of the geomagnetic field. It is proposed to be located in the avian retina, and be mediated by a light-induced, biochemical radical-pair mechanism involving cryptochromes as putative receptor molecules. At the same time, cryptochromes are known for their role in the negative feedback loop in the circadian clock. We measured gene expression of Cry1, Cry2 and Cry4 in the retina, muscle and brain of zebra finches over the circadian day to assess whether they showed any circadian rhythmicity...
March 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29577261/clock-genes-alterations-and-endocrine-disorders
#5
REVIEW
Anna Angelousi, Eva Kassi, Narjes Nasiri-Ansari, Martin O Weickert, Harpal Randeva, Gregory Kaltsas
BACKGROUND: Various endocrine signals oscillate over the 24-hour period and so does the responsiveness of target tissues. These daily oscillations do not occur solely in response to external stimuli but are also under the control of an intrinsic circadian clock. DESIGN: We searched the PubMed database to identify studies describing the associations of clock genes with endocrine diseases. RESULTS: Various human single nucleotide polymorphisms of BMAL1 and CLOCK genes exhibited significant associations with type 2 diabetes mellitus...
March 25, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29561841/fin219-jar1-and-cryptochrome1-antagonize-each-other-to-modulate-photomorphogenesis-under-blue-light-in-arabidopsis
#6
Huai-Ju Chen, Tsu-Yu Fu, Shao-Li Yang, Hsu-Liang Hsieh
Plant development is affected by the integration of light and phytohormones, including jasmonates (JAs). To address the molecular mechanisms of possible interactions between blue light and JA signaling in Arabidopsis thaliana, we used molecular and transgenic approaches to understand the regulatory relationships between FAR-RED INSENSITIVE 219 (FIN219)/JASMONATE RESISTANT1 (JAR1) and the blue-light photoreceptor cryptochrome1 (CRY1). FIN219 overexpression in the wild type resulted in a short-hypocotyl phenotype under blue light...
March 21, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29561690/differential-roles-for-cryptochromes-in-the-mammalian-retinal-clock
#7
Jovi C Y Wong, Nicola J Smyllie, Gareth T Banks, Carina A Pothecary, Alun R Barnard, Elizabeth S Maywood, Aarti Jagannath, Steven Hughes, Gijsbertus T J van der Horst, Robert E MacLaren, Mark W Hankins, Michael H Hastings, Patrick M Nolan, Russell G Foster, Stuart N Peirson
Cryptochromes 1 and 2 (CRY1/2) are key components of the negative limb of the mammalian circadian clock. Like many peripheral tissues, Cry1 and -2 are expressed in the retina, where they are thought to play a role in regulating rhythmic physiology. However, studies differ in consensus as to their localization and function, and CRY1 immunostaining has not been convincingly demonstrated in the retina. Here we describe the expression and function of CRY1 and -2 in the mouse retina in both sexes. Unexpectedly, we show that CRY1 is expressed throughout all retinal layers, whereas CRY2 is restricted to the photoreceptor layer...
March 21, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29556064/an-evolutionary-hotspot-defines-functional-differences-between-cryptochromes
#8
Clark Rosensweig, Kimberly A Reynolds, Peng Gao, Isara Laothamatas, Yongli Shan, Rama Ranganathan, Joseph S Takahashi, Carla B Green
Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME 1/2 (CRY1/2) and PER1/2). To understand the structural principles of regulation, we used evolutionary sequence analysis to identify co-evolving residues within the CRY/PHL protein family. Here we report the identification of an ancestral secondary cofactor-binding pocket as an interface in repressive CRYs, mediating regulation through direct interaction with CLOCK and BMAL1...
March 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29548611/circadian-calcium-feeding-regime-in-laying-hens-related-to-zinc-concentration-gene-expression-of-circadian-clock-calcium-transporters-and-oxidative-status
#9
Xue Lin, Yilin Liu, Tiantian Meng, Chunyan Xie, Xin Wu, Yulong Yin
The study was conducted to investigate the effects of different circadian calcium feeding regimes on parameters of Zn status and gene expression of circadian clock, calcium transporters and oxidative status in laying hens. In total, 180 of 41-weeks Brown Hy-line laying hens were assigned randomly into three groups, 1-CON group (Control Ca, diets contained 3.4% Ca at both 0730 and 1530 h), 2-HL group (High-low Ca, diets contained 3.6%-3.2% Ca respectively) and 3-LH group (Low-high Ca, diets contained 3.2%-3...
March 8, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29534992/the-cryptochrome-inhibitor-ks15-enhances-e-box-mediated-transcription-by-disrupting-the-feedback-action-of-a-circadian-transcription-repressor-complex
#10
Jaebong Jang, Sooyoung Chung, Youjeong Choi, Hye Young Lim, Yeongeon Son, Sung Kook Chun, Gi Hoon Son, Kyungjin Kim, Young-Ger Suh, Jong-Wha Jung
AIMS: We have previously identified a chemical scaffold possessing 2-ethoxypropanoic acid (designated as KS15) that directly binds to the C-terminal region of cryptochromes (CRYs: CRY1 and CRY2) and enhances E-box-mediated transcription. However, it is still unclear how KS15 impairs the feedback actions of the CRYs and which chemical moieties are functionally important for its actions. MAIN METHODS: The E-box-mediated transcriptional activities were mainly used to examine the effects of KS15 and its derivatives...
March 10, 2018: Life Sciences
https://www.readbyqxmd.com/read/29481323/nrf2-regulates-core-and-stabilizing-circadian-clock-loops-coupling-redox-and-timekeeping-in-mus-musculus
#11
Ryan S Wible, Chidambaram Ramanathan, Carrie Hayes Sutter, Kristin M Olesen, Thomas W Kensler, Andrew C Liu, Thomas R Sutter
Diurnal oscillation of intracellular redox potential is known to couple metabolism with the circadian clock, yet the responsible mechanisms are not well understood. We show here that chemical activation of NRF2 modifies circadian gene expression and rhythmicity, with phenotypes similar to genetic NRF2 activation. Loss of Nrf2 function in mouse fibroblasts, hepatocytes and liver also altered circadian rhythms, suggesting that NRF2 stoichiometry and/or timing of expression are important to timekeeping in some cells...
February 26, 2018: ELife
https://www.readbyqxmd.com/read/29466738/cry2-is-critical-for-circadian-regulation-of-myogenic-differentiation-by-bclaf1-mediated-mrna-stabilization-of-cyclin-d1-and-tmem176b
#12
Matthew Lowe, Jacob Lage, Ellen Paatela, Dane Munson, Reilly Hostager, Ce Yuan, Nobuko Katoku-Kikyo, Mercedes Ruiz-Estevez, Yoko Asakura, James Staats, Mulan Qahar, Michaela Lohman, Atsushi Asakura, Nobuaki Kikyo
Circadian rhythms regulate cell proliferation and differentiation; however, little is known about their roles in myogenic differentiation. Our synchronized differentiation studies demonstrate that myoblast proliferation and subsequent myotube formation by cell fusion occur in circadian manners. We found that one of the core regulators of circadian rhythms, Cry2, but not Cry1, is critical for the circadian patterns of these two critical steps in myogenic differentiation. This is achieved through the specific interaction between Cry2 and Bclaf1, which stabilizes mRNAs encoding cyclin D1, a G1/S phase transition regulator, and Tmem176b, a transmembrane regulator for myogenic cell fusion...
February 20, 2018: Cell Reports
https://www.readbyqxmd.com/read/29463750/light-activated-protein-interaction-with-high-spatial-subcellular-confinement
#13
Lorena Benedetti, Andrew E S Barentine, Mirko Messa, Heather Wheeler, Joerg Bewersdorf, Pietro De Camilli
Methods to acutely manipulate protein interactions at the subcellular level are powerful tools in cell biology. Several blue-light-dependent optical dimerization tools have been developed. In these systems one protein component of the dimer (the bait) is directed to a specific subcellular location, while the other component (the prey) is fused to the protein of interest. Upon illumination, binding of the prey to the bait results in its subcellular redistribution. Here, we compared and quantified the extent of light-dependent dimer occurrence in small, subcellular volumes controlled by three such tools: Cry2/CIB1, iLID, and Magnets...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29455641/circadian-pathway-genetic-variation-and-cancer-risk-evidence-from-genome-wide-association-studies
#14
Simone Mocellin, Saveria Tropea, Clara Benna, Carlo Riccardo Rossi
BACKGROUND: Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the association between circadian pathway genetic variation and risk of developing common cancers based on the findings of genome-wide association studies (GWASs). METHODS: Single nucleotide polymorphisms (SNPs) of 17 circadian genes reported by three GWAS meta-analyses dedicated to breast (Discovery, Biology, and Risk of Inherited Variants in Breast Cancer (DRIVE) Consortium; cases, n = 15,748; controls, n = 18,084), prostate (Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium; cases, n = 14,160; controls, n = 12,724) and lung carcinoma (Transdisciplinary Research In Cancer of the Lung (TRICL) Consortium; cases, n = 12,160; controls, n = 16,838) in patients of European ancestry were utilized to perform pathway analysis by means of the adaptive rank truncated product (ARTP) method...
February 19, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29451423/replication-of-type-2-diabetes-associated-variants-in-a-saudi-arabian-population
#15
Ruifang Li-Gao, Salma Majid Wakil, Brian F Meyer, Nduna Dzimiri, Dennis O Mook-Kanamori
Over 120 type 2 diabetes (T2D) loci have been identified from genome-wide association analysis (GWAS), mainly from Caucasian populations. Very limited knowledge is available on the Saudi Arabian population. In this study, 122 previously reported T2D related variants from 84 loci were examined in a Saudi Arabian cohort of 1,578 individuals (659 T2D cases and 919 controls). Eleven SNPs corresponding to 9 independent loci had a p-value <0.05. If a more stringent Bonferroni threshold of p=4.1×10 -4 (=0.05/122) was applied, none of the SNPs would have reached the significance level...
February 16, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29432611/when-the-whole-is-not-greater-than-the-sum-of-the-parts-a-critical-review-of-laboratory-bioassay-effects-testing-for-insecticidal-protein-interactions
#16
Frederick S Walters, Gerson Graser, Andrea Burns, Alan Raybould
Many studies have been conducted to investigate synergism among insecticidal proteins; however, a consensus on minimal data requirements and interpretation is lacking. While some have concluded that all additive predictive-type models should be abandoned, we advocate that additivity models can remain useful as assessment tools and that an appropriately designed interaction study will never systematically underestimate the existence of synergism, irrespective of which additivity model (or none at all) may be used...
February 8, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29408621/integrated-analysis-of-gene-expression-signatures-associated-with-colon-cancer-from-three-datasets
#17
Ping Gao, Miao He, Chunling Zhang, Changhui Geng
PURPOSE: The present study aimed to elucidate the pathogenesis of colon cancer and identify genes associated with tumor development. METHODS: Three datasets, two (GSE74602 and GSE44861) from the Gene Expression Omnibus database and RNA-Seq colon cancer data from The Cancer Genome Atlas data portal, were downloaded. These three datasets were grouped using a meta-analysis approach, and differentially expressed genes (DEGs) were identified between colon tumor samples and adjacent normal samples...
February 3, 2018: Gene
https://www.readbyqxmd.com/read/29371954/integrated-hepatic-transcriptional-and-serum-metabolic-studies-on-circulating-nutrient-metabolism-in-diurnal-laying-hens
#18
Wan Dan, Liu Yi-Lin, Li Guan-Ya, Huang Rui-Lin, Zhang Yi-Ming, Long Ci-Min, Ruan Zheng, Li Lan, Wu Xin, Zhou Xi-Hong, Yin Yu-Long
The aim of the study was to see the diurnal variation of nutrients metabolism and their regulation under the management of large-scaled production. The hepatic transcriptional and serum metabolic studies on circulating nutrient metabolism were investigated in diurnal laying hens. Liver and blood were collected from 36 hens that were slaughtered at 3:30, 7:30, 11:30, 15:30, 19:30, and 23:30 (n = 6), respectively. The serum amino acid, fatty acid and glucose levels, as well as the hepatic transcriptome were analyzed...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29370529/temporal-expression-of-clock-genes-in-central-and-peripheral-tissues-of-spotted-munia-under-varying-light-conditions-evidence-for-circadian-regulation-of-daily-physiology-in-a-non-photoperiodic-circannual-songbird-species
#19
Neha Agarwal, Ila Mishra, Sangeeta Rani, Vinod Kumar
We investigated if the duration and/or frequency of the light period affect 24-h rhythm of circadian clock genes in central and peripheral tissues of a non-photoperiodic songbird, the spotted munia (Lonchura punctulata), in which a circannual rhythm regulates the reproductive cycle. We monitored activity-rest pattern and measured 24-h mRNA oscillation of core clock (Bmal1, Clock, Per2, Cry1 and Cry2) and clock-controlled (E4bp4, Rorα and Rev-erbα) genes in the hypothalamus, retina, liver and gut of spotted munia subjected to an aberrant light-dark (LD) cycle (3...
January 25, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29338682/soybean-mads-box-gene-gmagl1-promotes-flowering-via-the-photoperiod-pathway
#20
Xuanrui Zeng, Hailun Liu, Hongyang Du, Sujing Wang, Wenming Yang, Yingjun Chi, Jiao Wang, Fang Huang, Deyue Yu
BACKGROUND: The MADS-box transcription factors are an ancient family of genes that regulate numerous physiological and biochemical processes in plants and facilitate the development of floral organs. However, the functions of most of these transcription factors in soybean remain unknown. RESULTS: In this work, a MADS-box gene, GmAGL1, was overexpressed in soybean. Phenotypic analysis showed that GmAGL1 overexpression not only resulted in early maturation but also promoted flowering and affected petal development...
January 16, 2018: BMC Genomics
keyword
keyword
51467
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"