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Dean Eurich

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https://www.readbyqxmd.com/read/27908558/time-varying-risk-for-breast-cancer-following-initiation-of-glucose-lowering-therapy-in-women-with-type-2-diabetes-exploring-detection-bias
#1
Samantha L Bowker, Mu Lin, Dean T Eurich, Jeffrey A Johnson
OBJECTIVES: To explore detection bias in the association between glucose-lowering therapies and breast cancer in a cohort of women with type 2 diabetes. METHODS: This was a retrospective, population-based cohort study. We identified new users of metformin, sulfonylureas, thiazolidinediones and insulin during the index period of January 1, 2003, to December 31, 2010. The main outcome was incident breast cancer, and patients were followed up from drug exposure index date until death, diagnosis of another type of cancer, termination of medical insurance or December 31, 2010...
November 29, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27903089/walking-and-type-2-diabetes-risk-using-canrisk-scores-among-older-adults
#2
Steven T Johnson, Dean T Eurich, Ellina Lytvyak, Ana Mladenovic, Lorian M Taylor, Jeffrey A Johnson, Jeff K Vallance
The objective of this study was to determine the association between pedometer-assessed steps and type 2 diabetes risk using the Public Health Agency of Canada-developed 16-item Canadian Diabetes Risk Questionnaire (CANRISK) among a large population-based sample of older adults across Alberta, Canada. To achieve our study objective, adults without type 2 diabetes (N = 689) aged 55 years and older provided demographic data and CANRISK scores through computer-assisted telephone interviews between September and November 2012...
September 8, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27861340/prognostic-factors-associated-with-mortality-and-major-in-hospital-complications-in-patients-with-bacteremic-pneumococcal-pneumonia-population-based-study
#3
Jessica A Beatty, Sumit R Majumdar, Gregory J Tyrrell, Thomas J Marrie, Dean T Eurich
Bacteremic pneumococcal pneumonia (BPP) causes considerable mortality and morbidity. We aimed to identify prognostic factors associated with mortality and major in-hospital complications in BPP.A prospective, population-based clinical registry of 1636 hospitalized adult patients (≥18 years) with BPP was established between 2000 and 2010 in Northern Alberta, Canada. Prognostic factors for mortality and major in-hospital complications (e.g., cardiac events, mechanical ventilation, aspiration) were evaluated using multivariable logistic regression...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27730284/quality-indicators-of-continuous-renal-replacement-therapy-crrt-care-in-critically-ill-patients-a-systematic-review
#4
Oleksa G Rewa, Pierre-Marc Villeneuve, Philippe Lachance, Dean T Eurich, Henry T Stelfox, R T Noel Gibney, Lisa Hartling, Robin Featherstone, Sean M Bagshaw
OBJECTIVES: Renal replacement therapy is increasingly utilized in the intensive care unit (ICU), of which continuous renal replacement therapy (CRRT) is most common. Despite CRRT being a relatively invasive and resource intensive technology, there remains wide practice variation in its application. This systematic review appraised the evidence for quality indicators (QIs) of CRRT care in critically ill patients. DESIGN: A comprehensive search strategy was developed and performed in five citation databases (Medline, Embase, CINAHL, Cochrane Library, and PubMed) and select grey literature sources...
October 11, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27590561/asplenic-patients-and-invasive-pneumococcal-disease-how-bad-is-it-these-days
#5
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
OBJECTIVES: Most are aware of pneumococcal infection as a complication of splenectomy and the increased risk of severe invasive pneumococcal disease (IPD) in asplenic patients. However little is known of the current status of this entity in a population with an active pneumococcal conjugate vaccine program for children. METHODS: All IPD cases reported from 2000 to 2014 in Northern Alberta, Canada were collected prospectively. Socio-demographic variables, clinical characteristics, and IPD-related outcomes were compared between patients with and without a spleen using the Student t-test, Chi-square test, or Fisher's exact test, as appropriate...
August 30, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27581815/community-pharmacists-assisting-in-total-cardiovascular-health-cpatch-a-cluster-randomized-controlled-trial-testing-a-focused-adherence-strategy-involving-community-pharmacies
#6
David F Blackburn, Charity D Evans, Dean T Eurich, Kerry D Mansell, Derek J Jorgenson, Jeff G Taylor, William M Semchuk, Yvonne M Shevchuk, Alfred J Remillard, David A Tran, Anne P Champagne
STUDY OBJECTIVE: To test a brief intervention for preventing statin nonadherence among community pharmacy patrons. DESIGN: Prospective, cluster-randomized, controlled trial (the Community Pharmacists Assisting in Total Cardiovascular Health [CPATCH] trial). SETTING: Thirty community pharmacies in Saskatchewan, Canada. PATIENTS: Participating pharmacies were randomized to 15 intervention pharmacies where a brief statin adherence intervention was delivered by pharmacists (intervention group [907 patients]) or 15 usual care pharmacies where no statin adherence intervention was delivered (usual care group [999 patients]) to new users of statins (defined as less than 1 yr of statin therapy)...
October 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27310986/treated-glycosylated-hemoglobin-levels-in-individuals-with-diabetes-mellitus-vary-little-by-health-status-a-retrospective-cohort-study
#7
Finlay A McAlister, Erik Youngson, Dean T Eurich
As choosing wisely has raised the issue of whether some individuals with type 2 diabetes may be overtreated, we examined the intensity of glycemic control across health status strata defined by comorbidities or frailty.This is a retrospective cohort study of commercially insured patients from 50 US states (Clinformatics Data Mart). We evaluated treated HbA1c levels in adults with new diabetes diagnosed between January 2004 and December 2009 who had HbA1C measured after at least 1 year of follow-up.Of 191,590 individuals with diabetes, 78...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27307411/medication-adherence-affects-risk-of-new-diabetes-complications-a-cohort-study
#8
Scot H Simpson, Mu Lin, Dean T Eurich
BACKGROUND: Previous outcomes-based studies of adherence to diabetes medications have focused on glycemic control and are limited by questions of temporality and uncontrolled confounding. OBJECTIVE: This retrospective cohort study of new oral antidiabetic medication users examined the effect of adherence on risk of incident macrovascular and microvascular complications. METHODS: A nationwide integrated insurance claims and laboratory database was used to identify new oral antidiabetic medication users between January 2004 and December 2009...
September 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27151328/current-smoking-and-reduced-mortality-in-bacteremic-pneumococcal-pneumonia-a-population-based-cohort-study
#9
Jessica A Beatty, Sumit R Majumdar, Gregory J Tyrrell, Thomas J Marrie, Dean T Eurich
BACKGROUND: Previous studies suggest that smoking is independently associated with decreased mortality in patients with pneumonia. We hypothesized that this is a result of acquiring differential pneumococcal serotypes (ie, smokers with pneumococcal pneumonia are more likely to experience bacteremia, with low case fatality rate (CFR) serotypes). We tested this hypothesis in a population-based cohort of patients with bacteremic pneumococcal pneumonia (BPP). METHODS: Our prospective population-based clinical registry included 1,636 adults (≥ 18 years) with BPP who were hospitalized between 2000 and 2010 in northern Alberta, Canada...
September 2016: Chest
https://www.readbyqxmd.com/read/27103415/correlates-of-general-and-domain-specific-sitting-time-among-older-adults
#10
Jeff K Vallance, Dean T Eurich, Brigid M Lynch, Paul A Gardiner, Lorian M Taylor, Barbara J Jefferis, Steven T Johnson
OBJECTIVE: We examined the correlates of sitting time in a population-based sample of older adults. METHODS: Adults >55 years of age (N = 1296; N = 515 employed; N = 781 unemployed) self-reported measures of demographic and health-related variables, and a measure of sitting time (ie, SIT-Q). RESULTS: Employed total sitting time (min/day) was positively associated with home Internet access (B = 71.2, 95% CI, 8.9 to 133.4, p = .025), body mass index (BMI) (kg/m(2); B = 7...
May 2016: American Journal of Health Behavior
https://www.readbyqxmd.com/read/27102581/dose-response-relationship-between-sulfonylureas-and-major-adverse-cardiovascular-events-in-elderly-patients-with-type-2-diabetes
#11
Ahmed S Abdelmoneim, Dean T Eurich, Ambikaipakan Senthilselvan, Weiyu Qiu, Scot H Simpson
PURPOSE: The objective of this study was to determine if there is a dose-response relationship between sulfonylureas and major adverse cardiovascular events (MACE). METHODS: We conducted a retrospective cohort study among elderly patients with no history of acute coronary syndrome or stroke who initiated gliclazide or glyburide therapy between 1998 and 2010. Gliclazide and glyburide users were evaluated separately, and a high-dimensional propensity score (HDPS) was used to match patients initiating therapy with a low or high dose...
April 22, 2016: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/27061884/safety-of-concomitant-metformin-and-proton-pump-inhibitor-use-a-population-retrospective-cohort-study
#12
Christopher B Chen, Mu Lin, Dean T Eurich, Jeffrey A Johnson
PURPOSE: The purpose of this study was to investigate the effect of concomitant use on important clinical outcomes. METHODS: In this retrospective cohort study, a cohort of new metformin users was identified between 2004 and 2010 and followed up until termination of insurance coverage, December 31, 2010, or the outcomes were reached. The primary outcome was a composite of time to all-cause mortality or hospitalization; our secondary outcome was time to cardiovascular hospitalization...
June 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/26930183/does-sitagliptin-affect-the-rate-of-osteoporotic-fractures-in-type-2-diabetes-population-based-cohort-study
#13
Sumit R Majumdar, Robert G Josse, Mu Lin, Dean T Eurich
CONTEXT: Type 2 diabetes and osteoporosis are both common, chronic, and increase with age, whereas type 2 diabetes is also a risk factor for major osteoporotic fractures (MOFs). However, different treatments for type 2 diabetes can affect fracture risk differently, with metaanalyses showing some agents increase risk (eg, thiazolidinediones) and some reduce risk (eg, sitagliptin). OBJECTIVE: To determine the independent association between new use of sitagliptin and MOF in a large population-based cohort study...
May 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26807539/the-interplay-between-continuity-of-care-multimorbidity-and-adverse-events-in-patients-with-diabetes
#14
Daniala L Weir, Finlay A McAlister, Sumit R Majumdar, Dean T Eurich
OBJECTIVES: To evaluate the impact of continuity of care and multimorbidity on health outcomes in patients with diabetes. RESEARCH DESIGN: Using a US claims database of insured patients, we identified those with incident diabetes between 2004 and 2008 and followed them until death, disenrollment, or December 31, 2010. Continuity of care was defined using Breslau's Usual Provider of Continuity (UPC; proportion of visits to the usual or predominant provider within 2 y of diabetes diagnosis)...
April 2016: Medical Care
https://www.readbyqxmd.com/read/26683784/multiple-domain-versus-single-domain-measurements-of-socioeconomic-status-ses-for-predicting-nonadherence-to-statin-medications-an-observational-population-based-cohort-study
#15
Mhd Wasem Alsabbagh, Lisa M Lix, Dean Eurich, Thomas W Wilson, David F Blackburn
INTRODUCTION: Low socioeconomic status (SES) should be a robust predictor of medication nonadherence because it shares key features with the theoretical origins of this phenomenon. However, population-based studies have demonstrated weak associations overall, possibly because SES is inadequately represented. We compared the performance of multiple versus single-domain measures of SES as predictors of statin adherence. METHODS: This retrospective cohort study used population-based administrative data mapped to area-level census information of individuals who received a statin medication following a hospitalization for coronary heart disease...
February 2016: Medical Care
https://www.readbyqxmd.com/read/26645240/-1-h-nmr-urinary-metabolomic-profiling-for-diagnosis-of-gastric-cancer
#16
Angela W Chan, Pascal Mercier, Daniel Schiller, Robert Bailey, Sarah Robbins, Dean T Eurich, Michael B Sawyer, David Broadhurst
BACKGROUND: Metabolomics has shown promise in gastric cancer (GC) detection. This research sought to identify whether GC has a unique urinary metabolomic profile compared with benign gastric disease (BN) and healthy (HE) patients. METHODS: Urine from 43 GC, 40 BN, and 40 matched HE patients was analysed using (1)H nuclear magnetic resonance ((1)H-NMR) spectroscopy, generating 77 reproducible metabolites (QC-RSD <25%). Univariate and multivariate (MVA) statistics were employed...
January 12, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/26486783/associations-of-daily-pedometer-steps-and-self-reported-physical-activity-with-health-related-quality-of-life-results-from-the-alberta-older-adult-health-survey
#17
Jeff Vallance, Dean Eurich, Paul Gardiner, Lorian Taylor, Steven Johnson
OBJECTIVE: The aim of this article is to examine associations of self-reported physical activity (PA) and pedometer steps with health-related quality of life (HRQoL) among a population-based sample of older adults. METHOD: Adults ≥55 years (N = 1,296) were recruited through random-digit dialing and responded to a questionnaire via computer-assisted telephone interviewing methods. Questionnaires assessed demographic variables and validated measures of PA and HRQoL...
June 2016: Journal of Aging and Health
https://www.readbyqxmd.com/read/26386939/sulfonylurea-use-is-associated-with-larger-infarct-size-in-patients-with-diabetes-and-st-elevation-myocardial-infarction
#18
Ahmed S Abdelmoneim, Robert C Welsh, Dean T Eurich, Scot H Simpson
BACKGROUND: Animal models have demonstrated that sulfonylureas increase the size of myocardial infarction; however, data in humans is scarce. This study evaluated the association between sulfonylurea use and infarct size in diabetes patients with ST-elevation myocardial infarction (STEMI). METHODS: Consecutive STEMI patients admitted in Edmonton, Canada between 2006 and 2011 were enrolled in a regional prospective registry program. Patients with type 2 diabetes were identified from this group and the maximum recorded troponin I (max cTnI) within the first 48 h of chest pain onset was used as the primary outcome to quantify infarct size...
January 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26341583/comparison-of-drug-coverage-in-canada-before-and-after-the-establishment-of-the-pan-canadian-pharmaceutical-alliance
#19
Debbie Milliken, Jaya Venkatesh, Rebecca Yu, Zhuo Su, Melissa Thompson, Dean Eurich
OBJECTIVES: This study was conducted to determine whether establishment of the pan-Canadian Pharmaceutical Alliance (pCPA) was associated with significant changes in drug listing decisions across Canada. ANALYSIS AND RESULTS: This study included drug indications that received a Common Drug Review or pan-Canadian Oncology Drug Review listing recommendation within 3 years before ('pre-PCPA era' group; n=79) and 3 years after ('PCPA era' group; n=91) the pCPA was established in August 2010...
2015: BMJ Open
https://www.readbyqxmd.com/read/26289255/the-comparative-effectiveness-of-angiotensin-converting-enzyme-inhibitors-and-angiotensin-ii-receptor-blockers-in-patients-with-diabetes
#20
Raj Padwal, Mu Lin, Dean T Eurich
The evidence examining the effect of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) on mortality in high-risk patients is conflicting. To further examine this controversy, the authors compared outcomes between ACE inhibitors and ARBs in a large clinical diabetes registry. A retrospective cohort of 87,472 incident users followed for 105,702 patient-years was analyzed. Average age was 53.1±10.1 years, 54.2% were men, and 14.4% had cardiovascular disease. All-cause hospitalization or all-cause mortality, the composite primary endpoint, occurred in 10,943 (12...
March 2016: Journal of Clinical Hypertension
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