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Dean Eurich

Jessica J Hopkins, Daniel Skubleny, David L Bigam, Vickie E Baracos, Dean T Eurich, Michael B Sawyer
BACKGROUND: Measurement of body composition by computed tomography (CT) is an advancing field. Sarcopenia, myosteatosis, and visceral obesity (VO) have been identified as predictive of survival in colorectal cancer (CRC). We performed a systematic review of contemporary studies to characterize this association and highlight methodological inconsistencies. METHODS: MEDLINE and PubMed were queried for articles published from January 2000 on, with populations of resectable CRC and with CT-measured body composition and survival data...
February 27, 2018: Annals of Surgical Oncology
Dean Trevor Eurich, Karly A Achtymichuk, Jeffrey A Johnson, Jashu K Minhas-Sandhu, Mu Lin
BACKGROUND: Objectives: To develop a healthy user index to serve as a method of confounding adjustment in future observational studies of preventive therapies. METHODS: A large administrative database of patients with type 2 diabetes was split in half randomly, yielding derivation and validation cohorts. Influenza vaccination was used as a 'prototypical marker' of a healthy user. In our derivation cohort, we fitted a mixed effects logistic regression model, and a points-based system was used to construct the index...
November 22, 2017: Journal of Population Therapeutics and Clinical Pharmacology
Christopher B Chen, Maxim Eskin, Dean T Eurich, Sumit R Majumdar, Jeffrey A Johnson
BACKGROUND: Metformin is associated with a reduced risk of some cancers but its effect on prostate cancer is unclear. Some studies suggest only Asians derive this benefit. Therefore, we undertook a systematic review with particular attention to ethnicity. METHODS: Medline, Embase, Scopus, Web of Science, and EBM Reviews were searched from inception to 2015. Two reviewers identified and abstracted articles. Studies were pooled using random effects model and stratified by Western- vs Asian-based populations...
January 10, 2018: BMC Cancer
Ming Ye, Paula J Robson, Dean T Eurich, Jennifer E Vena, Jian-Yi Xu, Jeffrey A Johnson
AIMS: Previous observational studies using administrative health records have suggested an increased risk of diabetes with use of antibiotics. However, unmeasured confounding factors may explain these results. This study characterized the association between systemic use of antibiotics and risk of diabetes in a cohort of adults in Canada, accounting for both clinical and self-reported disease risk factors. MATERIALS AND METHODS: In this nested case-control study, we used data from Alberta's Tomorrow Project (ATP), a longitudinal cohort study in Canada, and the linked administrative health records (2000-2015)...
November 20, 2017: Diabetes, Obesity & Metabolism
Ming Ye, Paula J Robson, Dean T Eurich, Jennifer E Vena, Jian-Yi Xu, Jeffrey A Johnson
Although obesity is a known risk factor for diabetes, the impact of body mass index (BMI) changes over time, especially BMI reduction, on diabetes development is less than clear. The objective of this study is to characterize the association between BMI changes over time and incidence of diabetes in a cohort of adults in Alberta. From 2000 to 2008, Alberta's Tomorrow Project (ATP) enrolled participants aged 35-69 to a population-based prospective cohort study. BMI was calculated from self-reported height and weight; change in BMI (∆BMI) was calculated as the difference between baseline and follow-up measurements...
January 2018: Preventive Medicine
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: There are many case reports of septic arthritis complicating invasive pneumococcal disease (IPD); however, no study has compared patients with IPD with septic arthritis to those who didn't develop septic arthritis Thus, we aimed to determine the rates of, and risk factors for, septic arthritis in patients with invasive pneumococcal disease (IPD). METHODS: Socio-demographic, clinical, and serological data were captured on all patients with IPD in Northern Alberta, Canada from 2000 to 2014...
October 12, 2017: BMC Infectious Diseases
Allison Soprovich, Sylvia El Kurdi, Dean T Eurich
IMPORTANCE: Canada's Common Drug Review (CDR) evaluates drug data from published and unpublished research, as well as input from patient groups, to recommend provincial coverage. Currently, the CDR process gives manufacturers the opportunity to redact information in the final publicly available report. Patients often have strong feelings regarding the efficacy, harms, health-related quality of life (HRQL), and cost associated with the drugs under review and their redacted data. Highlighting Canada's approach will hopefully build on the growing international concern regarding transparency of clinical study data...
September 11, 2017: BMJ Open
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
BACKGROUND: Although a considerable amount is known about the effect of age on the manifestations and outcomes of pneumonia, the same is not true for invasive pneumococcal disease. METHODS: This was a prospective observational study of all cases (2435) of invasive pneumococcal disease in adults in Northern Alberta from 2000 to 2014. Rates of invasive pneumococcal disease per 100,000, sociodemographic variables, clinical characteristics, and invasive pneumococcal disease-related outcomes were compared for the following age groups: 17-54, 55-64, 65-74, and ≥75 years...
January 2018: American Journal of Medicine
Katelynn Crick, Denise Thomson, Ricardo M Fernandes, Megan Nuspl, Dean T Eurich, Brian H Rowe, Lisa Hartling
BACKGROUND: Systematic reviews support health systems and clinical decision-making by identifying and summarizing all existing studies on a particular topic. In 2009, a comprehensive description of child-relevant systematic reviews published in the Cochrane Database of Systematic Reviews was compiled. This study aims to provide an update, and to describe these systematic reviews according to their content and methodological approaches. METHODS: All child-relevant systematic reviews published by the Cochrane Collaboration in the Cochrane Database of Systematic Reviews (CDSR) as of March, 2013 were identified and described in relation to their content and methodological approaches...
July 11, 2017: BMC Pediatrics
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
Little is known about concurrent infection with hepatitis C virus (HCV) and Streptococcus pneumoniae, which causes invasive pneumococcal disease (IPD). We hypothesized that co-infection with HCV and S. pneumoniae would increase risk for death and complications. We captured sociodemographic and serologic data for adults with IPD in a population-based cohort study in northern Alberta, Canada, during 2000-2014. IPD patients infected with HCV were compared with IPD patients not infected with HCV for risk of in-hospital deaths and complications by using multivariable logistic regression...
July 2017: Emerging Infectious Diseases
Morgan Schultz, Stephanie O Keeling, Steven J Katz, Walter P Maksymowych, Dean T Eurich, Jill J Hall
Leflunomide is indicated for the treatment of adults with rheumatoid arthritis, yet is underutilized. Given the cost of biologic therapy, understanding real-life effectiveness, safety, and sustainability of leflunomide, particularly in patients who have failed methotrexate, would be of value. The primary objective was to assess the proportion of patients achieving clinically meaningful benefit following an adequate trial of leflunomide. A retrospective analysis of a cohort supplemented with patient self-reported data using a standardized questionnaire...
July 2017: Clinical Rheumatology
Mhd Wasem Alsabbagh, Dean Eurich, Lisa M Lix, Thomas W Wilson, David F Blackburn
BACKGROUND: The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS: A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate...
April 20, 2017: BMC Medical Research Methodology
Dax G Rumsey, Jaime Guzman, Alan M Rosenberg, Adam M Huber, Rosie Scuccimarri, Natalie J Shiff, Alessandra Bruns, Brian M Feldman, Dean T Eurich
OBJECTIVE: To describe the prevalence, associated characteristics, and course of enthesitis in a juvenile idiopathic arthritis (JIA) inception cohort. METHODS: Canadian children newly diagnosed with JIA between 2005 and 2010 were categorized using International League of Associations for Rheumatology criteria at the 6-month visit and followed in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) cohort for up to 5 years. The presence of entheseal tenderness on examination at 33 sites shown on a homunculus was recorded at 0, 6, 12, 18, 24, 36, 48, and 60 months after enrollment...
February 2018: Arthritis Care & Research
T J Marrie, G J Tyrrell, Sumit R Majumdar, Dean T Eurich
Background. Large studies of invasive pneumococcal disease (IPD) are frequently lacking detailed clinical information. Methods. A population-based 15-year study of IPD in Northern Alberta. Results. 2435 patients with a mean age of 54.2 years formed the study group. Males outnumbered females and Aboriginal and homeless persons were overrepresented. High rates of smoking, excessive alcohol use, and illicit drug use were seen. Almost all (87%) had a major comorbidity and 15% had functional limitations prior to admission...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Finlay A McAlister, Erik Youngson, Dean T Eurich
BACKGROUND: Whether treatment deintensification in Americans with diabetes mellitus varies by glycemic control, health status, and calendar year (before/after February 2008 when safety concerns about intensive glucose control were reported in the ACCORD trial [Action to Control Cardiovascular Risk in Diabetes]) is unclear. METHODS AND RESULTS: We defined deintensification as discontinuation or dosage decrease of at least 1 glycemic medication without addition of, or uptitration of, another agent in the 120 days after the index glycosylated hemoglobin (HbA1C) measurement...
April 2017: Circulation. Cardiovascular Quality and Outcomes
Scot H Simpson, Mu Lin, Dean T Eurich
BACKGROUND: Inducement programs can promote customer loyalty; however, the clinical effects of these programs are unknown. OBJECTIVE: To examine relationships among inducement program use, medication adherence, and health outcomes. METHODS: Alberta residents with ≥ 1 physician visit for diabetes or hypertension between April 2008 and March 2014 were eligible for this study and included if they were new statin users and alive at least 455 days after the first statin dispensation...
August 2017: Annals of Pharmacotherapy
Shannon L Turvey, Sean M Bagshaw, Dean T Eurich, Wendy I Sligl
Purpose. The impact of critical illness on survival of HIV-infected patients in the era of antiretroviral therapy remains uncertain. We describe the epidemiology of critical illness in this population and identify predictors of mortality. Materials and Methods. Retrospective cohort of HIV-infected patients was admitted to intensive care from 2002 to 2014. Patient sociodemographics, comorbidities, case-mix, illness severity, and 30-day mortality were captured. Multivariable Cox regression analyses were performed to identify predictors of mortality...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
Ming Ye, Paula J Robson, Dean T Eurich, Jennifer E Vena, Jian-Yi Xu, Jeffrey A Johnson
No abstract text is available yet for this article.
August 1, 2017: International Journal of Epidemiology
Tasneem Siyam, Sue Ross, Sandra Campbell, Dean T Eurich, Nesé Yuksel
BACKGROUND: It is unclear if the use of hormone therapy (HT) in carriers of BRCA mutations improves the quality of life (QOL) without increasing the risk of breast cancer following a risk-reducing salpingo-oophorectomy (RRSO). Our objective was to assess the effect of HT on QOL and breast cancer risk, after RRSO. METHODS: We searched MEDLINE, EMBASE, CINHAL, and others, from inception to July 22, 2016, to identify relevant studies. Two reviewers independently screened identified records for controlled trials and observational studies that addressed the effect of HT on QOL and breast cancer risk in women with BRCA mutations, post RRSO...
March 21, 2017: BMC Women's Health
Travis Featherstone, Dean T Eurich, Scot H Simpson
BACKGROUND: Undiagnosed diabetes can create significant management issues for seniors. OBJECTIVES: To evaluate the effectiveness of two diabetes risk surveys-the Canadian Diabetes Risk Assessment Questionnaire (CANRISK) and the Finnish Diabetes Risk Score (FINDRISC)-to identify elevated blood glucose levels in seniors. METHODS: A cross-sectional study was conducted in senior living facilities in Edmonton, Alberta, Canada. Those with known diabetes, without capacity, considered frail, or unable to communicate in English were excluded...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
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