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Dean Eurich

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https://www.readbyqxmd.com/read/28427340/does-the-association-between-adherence-to-statin-medications-and-mortality-depend-on-measurement-approach-a-retrospective-cohort-study
#1
Mhd Wasem Alsabbagh, Dean Eurich, Lisa M Lix, Thomas W Wilson, David F Blackburn
BACKGROUND: The aim of this study was to examine the relationship between mortality and statin adherence using two different approaches to adherence measurement (summary versus repeated-measures). METHODS: A retrospective cohort study was conducted using administrative data from Saskatchewan, Canada between 1994 and 2008. Eligible individuals received a prescription for a statin following hospitalization for acute coronary syndrome (ACS). Adherence was measured using proportion of days covered (PDC) expressed either as: 1) a fixed summary measure, or 2) as a repeatedly measured covariate...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28426894/characteristics-and-course-of-enthesitis-in-a-juvenile-idiopathic-arthritis-inception-cohort
#2
Dax G Rumsey, Jaime Guzman, Alan M Rosenberg, Adam M Huber, Rosie Scuccimarri, Natalie J Shiff, Alessandra Bruns, Brian M Feldman, Dean T Eurich
Objective To describe the prevalence, associated characteristics, and course of enthesitis in a juvenile idiopathic arthritis (JIA) inception cohort. Methods Canadian children newly diagnosed with JIA between 2005 and 2010 were categorized using ILAR criteria at the 6-month visit and followed in the ReACCh-Out cohort for up to 5 years. The presence of entheseal tenderness on examination at 33 sites shown on a homunculus was recorded at 0, 6, 12, 18, 24, 36, 48 and 60 months after enrolment. Enthesitis was defined as entheseal tenderness at more than one site or on more than one occasion...
April 20, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28424565/invasive-pneumococcal-disease-still-lots-to-learn-and-a-need-for-standardized-data-collection-instruments
#3
T J Marrie, G J Tyrrell, Sumit R Majumdar, Dean T Eurich
Background. Large studies of invasive pneumococcal disease (IPD) are frequently lacking detailed clinical information. Methods. A population-based 15-year study of IPD in Northern Alberta. Results. 2435 patients with a mean age of 54.2 years formed the study group. Males outnumbered females and Aboriginal and homeless persons were overrepresented. High rates of smoking, excessive alcohol use, and illicit drug use were seen. Almost all (87%) had a major comorbidity and 15% had functional limitations prior to admission...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28416531/treatment-deintensification-is-uncommon-in-adults-with-type-2-diabetes-mellitus-a-retrospective-cohort-study
#4
Finlay A McAlister, Erik Youngson, Dean T Eurich
BACKGROUND: Whether treatment deintensification in Americans with diabetes mellitus varies by glycemic control, health status, and calendar year (before/after February 2008 when safety concerns about intensive glucose control were reported in the ACCORD trial [Action to Control Cardiovascular Risk in Diabetes]) is unclear. METHODS AND RESULTS: We defined deintensification as discontinuation or dosage decrease of at least 1 glycemic medication without addition of, or uptitration of, another agent in the 120 days after the index glycosylated hemoglobin (HbA1C) measurement...
April 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28372491/community-pharmacy-based-inducement-programs-are-associated-with-better-medication-adherence-a-cohort-study
#5
Scot H Simpson, Mu Lin, Dean T Eurich
BACKGROUND: Inducement programs can promote customer loyalty; however, the clinical effects of these programs are unknown. OBJECTIVE: To examine relationships among inducement program use, medication adherence, and health outcomes. METHODS: Alberta residents with ≥ 1 physician visit for diabetes or hypertension between April 2008 and March 2014 were eligible for this study and included if they were new statin users and alive at least 455 days after the first statin dispensation...
April 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28348607/epidemiology-and-outcomes-in-critically-ill-patients-with-human-immunodeficiency-virus-infection-in-the-era-of-combination-antiretroviral-therapy
#6
Shannon L Turvey, Sean M Bagshaw, Dean T Eurich, Wendy I Sligl
Purpose. The impact of critical illness on survival of HIV-infected patients in the era of antiretroviral therapy remains uncertain. We describe the epidemiology of critical illness in this population and identify predictors of mortality. Materials and Methods. Retrospective cohort of HIV-infected patients was admitted to intensive care from 2002 to 2014. Patient sociodemographics, comorbidities, case-mix, illness severity, and 30-day mortality were captured. Multivariable Cox regression analyses were performed to identify predictors of mortality...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28338725/cohort-profile-alberta-s-tomorrow-project
#7
Ming Ye, Paula J Robson, Dean T Eurich, Jennifer E Vena, Jian-Yi Xu, Jeffrey A Johnson
No abstract text is available yet for this article.
December 21, 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28320467/the-effect-of-hormone-therapy-on-quality-of-life-and-breast-cancer-risk-after-risk-reducing-salpingo-oophorectomy-a-systematic-review
#8
Tasneem Siyam, Sue Ross, Sandra Campbell, Dean T Eurich, Nesé Yuksel
BACKGROUND: It is unclear if the use of hormone therapy (HT) in carriers of BRCA mutations improves the quality of life (QOL) without increasing the risk of breast cancer following a risk-reducing salpingo-oophorectomy (RRSO). Our objective was to assess the effect of HT on QOL and breast cancer risk, after RRSO. METHODS: We searched MEDLINE, EMBASE, CINHAL, and others, from inception to July 22, 2016, to identify relevant studies. Two reviewers independently screened identified records for controlled trials and observational studies that addressed the effect of HT on QOL and breast cancer risk in women with BRCA mutations, post RRSO...
March 21, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28292477/limited-effectiveness-of-diabetes-risk-assessment-tools-in-seniors-facility-residents
#9
Travis Featherstone, Dean T Eurich, Scot H Simpson
BACKGROUND: Undiagnosed diabetes can create significant management issues for seniors. OBJECTIVES: To evaluate the effectiveness of two diabetes risk surveys-the Canadian Diabetes Risk Assessment Questionnaire (CANRISK) and the Finnish Diabetes Risk Score (FINDRISC)-to identify elevated blood glucose levels in seniors. METHODS: A cross-sectional study was conducted in senior living facilities in Edmonton, Alberta, Canada. Those with known diabetes, without capacity, considered frail, or unable to communicate in English were excluded...
March 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28193610/risk-of-heart-failure-after-community-acquired-pneumonia-prospective-controlled-study-with-10-years-of-follow-up
#10
Dean T Eurich, Thomas J Marrie, Jasjeet K Minhas-Sandhu, Sumit R Majumdar
Objective To determine the attributable risk of community acquired pneumonia on incidence of heart failure throughout the age range of affected patients and severity of the infection.Design Cohort study.Setting Six hospitals and seven emergency departments in Edmonton, Alberta, Canada, 2000-02.Participants 4988 adults with community acquired pneumonia and no history of heart failure were prospectively recruited and matched on age, sex, and setting of treatment (inpatient or outpatient) with up to five adults without pneumonia (controls) or prevalent heart failure (n=23 060)...
February 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28166804/addressing-the-gaps-in-diabetes-care-in-first-nations-communities-with-the-reorganizing-the-approach-to-diabetes-through-the-application-of-registries-radar-the-project-protocol
#11
Dean T Eurich, Sumit R Majumdar, Lisa A Wozniak, Allison Soprovich, Kari Meneen, Jeffrey A Johnson, Salim Samanani
BACKGROUND: Type-2 diabetes rates in First Nations communities are 3-5 times higher than the general Canadian population, resulting in a high burden of disease, complications and comorbidity. Limited community nursing capacity, isolated environments and a lack of electronic health records (EHR)/registries lead to a reactive, disorganized approach to diabetes care for many First Nations people. The Reorganizing the Approach to Diabetes through the Application of Registries (RADAR) project was developed in alignments with federal calls for innovative, culturally relevant, community-specific programs for people with type-2 diabetes developed and delivered in partnership with target communities...
February 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/27908558/time-varying-risk-for-breast-cancer-following-initiation-of-glucose-lowering-therapy-in-women-with-type-2-diabetes-exploring-detection-bias
#12
Samantha L Bowker, Mu Lin, Dean T Eurich, Jeffrey A Johnson
OBJECTIVES: To explore detection bias in the association between glucose-lowering therapies and breast cancer in a cohort of women with type 2 diabetes. METHODS: This was a retrospective, population-based cohort study. We identified new users of metformin, sulfonylureas, thiazolidinediones and insulin during the index period of January 1, 2003, to December 31, 2010. The main outcome was incident breast cancer, and patients were followed up from drug exposure index date until death, diagnosis of another type of cancer, termination of medical insurance or December 31, 2010...
November 29, 2016: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/27903089/walking-and-type-2-diabetes-risk-using-canrisk-scores-among-older-adults
#13
Steven T Johnson, Dean T Eurich, Ellina Lytvyak, Ana Mladenovic, Lorian M Taylor, Jeffrey A Johnson, Jeff K Vallance
The objective of this study was to determine the association between pedometer-assessed steps and type 2 diabetes risk using the Public Health Agency of Canada-developed 16-item Canadian Diabetes Risk Questionnaire (CANRISK) among a large population-based sample of older adults across Alberta, Canada. To achieve our study objective, adults without type 2 diabetes (N = 689) aged 55 years and older provided demographic data and CANRISK scores through computer-assisted telephone interviews between September and November 2012...
January 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27861340/prognostic-factors-associated-with-mortality-and-major-in-hospital-complications-in-patients-with-bacteremic-pneumococcal-pneumonia-population-based-study
#14
Jessica A Beatty, Sumit R Majumdar, Gregory J Tyrrell, Thomas J Marrie, Dean T Eurich
Bacteremic pneumococcal pneumonia (BPP) causes considerable mortality and morbidity. We aimed to identify prognostic factors associated with mortality and major in-hospital complications in BPP.A prospective, population-based clinical registry of 1636 hospitalized adult patients (≥18 years) with BPP was established between 2000 and 2010 in Northern Alberta, Canada. Prognostic factors for mortality and major in-hospital complications (e.g., cardiac events, mechanical ventilation, aspiration) were evaluated using multivariable logistic regression...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27730284/quality-indicators-of-continuous-renal-replacement-therapy-crrt-care-in-critically-ill-patients-a-systematic-review
#15
REVIEW
Oleksa G Rewa, Pierre-Marc Villeneuve, Philippe Lachance, Dean T Eurich, Henry T Stelfox, R T Noel Gibney, Lisa Hartling, Robin Featherstone, Sean M Bagshaw
OBJECTIVES: Renal replacement therapy is increasingly utilized in the intensive care unit (ICU), of which continuous renal replacement therapy (CRRT) is most common. Despite CRRT being a relatively invasive and resource intensive technology, there remains wide practice variation in its application. This systematic review appraised the evidence for quality indicators (QIs) of CRRT care in critically ill patients. DESIGN: A comprehensive search strategy was developed and performed in five citation databases (Medline, Embase, CINAHL, Cochrane Library, and PubMed) and select grey literature sources...
October 11, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27590561/asplenic-patients-and-invasive-pneumococcal-disease-how-bad-is-it-these-days
#16
Thomas J Marrie, Gregory J Tyrrell, Sumit R Majumdar, Dean T Eurich
OBJECTIVES: Most are aware of pneumococcal infection as a complication of splenectomy and the increased risk of severe invasive pneumococcal disease (IPD) in asplenic patients. However little is known of the current status of this entity in a population with an active pneumococcal conjugate vaccine program for children. METHODS: All IPD cases reported from 2000 to 2014 in Northern Alberta, Canada were collected prospectively. Socio-demographic variables, clinical characteristics, and IPD-related outcomes were compared between patients with and without a spleen using the Student t-test, Chi-square test, or Fisher's exact test, as appropriate...
October 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27581815/community-pharmacists-assisting-in-total-cardiovascular-health-cpatch-a-cluster-randomized-controlled-trial-testing-a-focused-adherence-strategy-involving-community-pharmacies
#17
David F Blackburn, Charity D Evans, Dean T Eurich, Kerry D Mansell, Derek J Jorgenson, Jeff G Taylor, William M Semchuk, Yvonne M Shevchuk, Alfred J Remillard, David A Tran, Anne P Champagne
STUDY OBJECTIVE: To test a brief intervention for preventing statin nonadherence among community pharmacy patrons. DESIGN: Prospective, cluster-randomized, controlled trial (the Community Pharmacists Assisting in Total Cardiovascular Health [CPATCH] trial). SETTING: Thirty community pharmacies in Saskatchewan, Canada. PATIENTS: Participating pharmacies were randomized to 15 intervention pharmacies where a brief statin adherence intervention was delivered by pharmacists (intervention group [907 patients]) or 15 usual care pharmacies where no statin adherence intervention was delivered (usual care group [999 patients]) to new users of statins (defined as less than 1 yr of statin therapy)...
October 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27310986/treated-glycosylated-hemoglobin-levels-in-individuals-with-diabetes-mellitus-vary-little-by-health-status-a-retrospective-cohort-study
#18
MULTICENTER STUDY
Finlay A McAlister, Erik Youngson, Dean T Eurich
As choosing wisely has raised the issue of whether some individuals with type 2 diabetes may be overtreated, we examined the intensity of glycemic control across health status strata defined by comorbidities or frailty.This is a retrospective cohort study of commercially insured patients from 50 US states (Clinformatics Data Mart). We evaluated treated HbA1c levels in adults with new diabetes diagnosed between January 2004 and December 2009 who had HbA1C measured after at least 1 year of follow-up.Of 191,590 individuals with diabetes, 78...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27307411/medication-adherence-affects-risk-of-new-diabetes-complications-a-cohort-study
#19
Scot H Simpson, Mu Lin, Dean T Eurich
BACKGROUND: Previous outcomes-based studies of adherence to diabetes medications have focused on glycemic control and are limited by questions of temporality and uncontrolled confounding. OBJECTIVE: This retrospective cohort study of new oral antidiabetic medication users examined the effect of adherence on risk of incident macrovascular and microvascular complications. METHODS: A nationwide integrated insurance claims and laboratory database was used to identify new oral antidiabetic medication users between January 2004 and December 2009...
September 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27151328/current-smoking-and-reduced-mortality-in-bacteremic-pneumococcal-pneumonia-a-population-based-cohort-study
#20
Jessica A Beatty, Sumit R Majumdar, Gregory J Tyrrell, Thomas J Marrie, Dean T Eurich
BACKGROUND: Previous studies suggest that smoking is independently associated with decreased mortality in patients with pneumonia. We hypothesized that this is a result of acquiring differential pneumococcal serotypes (ie, smokers with pneumococcal pneumonia are more likely to experience bacteremia, with low case fatality rate (CFR) serotypes). We tested this hypothesis in a population-based cohort of patients with bacteremic pneumococcal pneumonia (BPP). METHODS: Our prospective population-based clinical registry included 1,636 adults (≥ 18 years) with BPP who were hospitalized between 2000 and 2010 in northern Alberta, Canada...
September 2016: Chest
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