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https://www.readbyqxmd.com/read/28992682/nanocurcumin-mediated-down-regulation-of-telomerase-via-stimulating-tgf%C3%AE-1-signaling-pathway-in-hepatocellular-carcinoma-cells
#1
Molood Shariati, Samira Hajigholami, Ziba Veisi Malekshahi, Maliheh Entezari, Narges Bodaghabadi, Majid Sadeghizadeh
Background: Curcumin, extracted from turmeric, represents enormous potential to serve as an anticancer agent. Telomerase is viewed as a prominent molecular target of curcumin, and Transforming growth factor-β1 (TGFβ1) has proven to be a major inhibitory signaling pathway for telomerase activity. In the current study, we aimed to explore suppressive effects of nanocurcumin on telomerase expression through TGFβ1 pathway in a hepatocellular carcinoma cell line (Huh7). Methods: MTT assay was used to determine the effect of nonocurcumin on viability of Huh7 cells...
October 10, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28991167/achiral-mannich-base-curcumin-analogs-induce-unfolded-protein-response-and-mitochondrial-membrane-depolarization-in-panc-1-cells
#2
Gábor J Szebeni, Árpád Balázs, Ildikó Madarász, Gábor Pócz, Ferhan Ayaydin, Iván Kanizsai, Roberta Fajka-Boja, Róbert Alföldi, László Hackler, László G Puskás
Achiral Mannich-type curcumin analogs have been synthetized and assayed for their cytotoxic activity. The anti-proliferative and cytotoxic activity of curcuminoids has been tested on human non-small-cell lung carcinoma (A549), hepatocellular carcinoma (HepG2) and pancreatic cancer cell line (PANC-1). Based on the highest anti-proliferative activity nine drug candidates were further tested and proved to cause phosphatidylserine exposure as an early sign of apoptosis. Curcumin analogs with the highest apoptotic activity were selected for mechanistic studies in the most sensitive PANC-1 cells...
October 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28972677/hepatocellular-uptake-of-cyclodextrin-complexed-curcumin-during-liver-preservation-a-feasibility-study
#3
Saber Abdelkader Saidi, Nicolas Meurisse, Ina Jochmans, Veerle Heedfeld, Tine Wylin, Jaakko Parkkinen, Jacques Pirenne, Diethard Monbaliu, Abdelfattah El Feki, Jos van Pelt
Increasing demand for donor organs and decreasing organ quality is prompting research toward new methods to reduce ischemia reperfusion injury (IRI). Several strategies have been proposed to protect the preserved organ from this injury. Before curcumin/dextrin complex (CDC), a potent antioxidant and anti-inflammatory agent, can be used clinically we need to better understand the intracellular uptake under hypothermic conditions on rat model of liver donation after circulatory death (DCD) and brain death (DBD)...
October 3, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28955769/electrozymographic-evaluation-of-the-attenuation-of-arsenic-induced-degradation-of-hepatic-sod-catalase-in-an-in-vitro-assay-system-by-pectic-polysaccharides-of-momordica-charantia-in-combination-with-curcumin
#4
Hasina Perveen, Moumita Dash, Shamima Khatun, Moulima Maity, Syed Sirajul Islam, Sandip Chattopadhyay
Momordica charantia (MC) fruit known as bitter gourd, is of potential nutritional and medicinal value. The objectives of the present in vitro study were to evaluate the efficacy of bioactive pectic polysaccharides (CCPS) of MC along with another well-known bioactive compound curcumin in the abrogation of hepatocellular oxidative stress persuaded by sodium arsenite. Electrozymographic method was developed for the assessment of superoxide dismutase (SOD) and catalase activities of liver tissues maintained under an in vitro system...
September 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28833603/metformin-incombination-with-curcumin-inhibits-the-growth-metastasis-and-angiogenesis-of-hepatocellular-carcinoma-in-vitro-and-in-vivo
#5
Hui-Hui Zhang, Ying Zhang, Yan-Na Cheng, Fu-Lian Gong, Zhan-Qi Cao, Lu-Gang Yu, Xiu-Li Guo
Hepatocellular carcinoma (HCC) has poor prognosis due to the advanced disease stages by the time it is diagnosed, high recurrence rates and metastasis. In the present study, we investigated the effects of metformin (a safe anti-diabetic drug) and curcumin (a turmeric polyphenol extracted from rhizome of Curcuma longa Linn.) on proliferation, apoptosis, invasion, metastasis and angiogenesis of HCC in vitro and in vivo. It was found that co-treatment of metformin and curcumin could not only induce tumor cells into apoptosis through activating the mitochondria pathways, but also suppress the invasion, metastasis of HCC cells and angiogenesis of HUVECs...
August 19, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28766664/tetrahydrocurcumin-is-more-effective-than-curcumin-in-inducing-the-apoptosis-of-h22-cells-via-regulation-of-a-mitochondrial-apoptosis-pathway-in-ascites-tumor-bearing-mice
#6
Weihai Liu, Zhenbiao Zhang, Guosheng Lin, Dandan Luo, Hanbin Chen, Hongmei Yang, Jiali Liang, Yuhong Liu, Jianhui Xie, Ziren Su, Hongying Cao
Curcumin (CUR), a widely used food additive, is derived mainly from Curcuma species that has been applied traditionally for the treatment of various diseases, including hepatocellular carcinoma (HCC). However, its poor systemic bioavailability hampers its clinical application, which may be related to its wide metabolism. Tetrahydrocurcumin (THC) is a major metabolite of CUR and has been reported to have multiple biologic activities. We investigated, for the first time, the efficacy and associated mechanism of action of THC and CUR in a H22 ascites tumor-bearing model in mice...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28652738/glycyrrhetinic-acid-functionalized-mesoporous-silica-nanoparticles-as-hepatocellular-carcinoma-targeted-drug-carrier
#7
Yongjiu Lv, Jingjing Li, Huali Chen, Yan Bai, Liangke Zhang
In this study, a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor targeting. MSN-GA exhibited satisfactory loading capacity for insoluble drugs, uniform size distribution, and specific tumor cell targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was covalently decorated on the surface of MSN via an amido bond. The successful synthesis of MSN-GA was validated by the results of Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and zeta potential measurement...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28611265/hepatoprotective-effect-of-curcumin-on-hepatocellular-carcinoma-through-autophagic-and-apoptic-pathways
#8
Ahmed Elmansi, Amro El-Karef, Mamdouh Shishtawy, Laila Eissa
BACKGROUND AND RATIONALE: Microtubule-associated protein light chain 3-II (LC3-II), and Sequestosome-1 (SQSTM1) are proteins that can be used as markers for autophagic pathway. Bcl-2 protein is reported to be inversely correlated with apoptosis. We aimed to investigate the effects of curcumin on liver inflammation and fibrosis up to the first dysplastic stage of Hepatocellular carcinoma (HCC) induced by Thioacetamide (TAA) in rats and to clarify the effects of curcumin on LC3-II, SQSTM1, and Bcl-2...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28455219/ph-sensitive-polymeric-nanoparticles-for-co-delivery-of-doxorubicin-and-curcumin-to-treat-cancer-via-enhanced-pro-apoptotic-and-anti-angiogenic-activities
#9
Jinming Zhang, Jingjing Li, Zhi Shi, Yang Yang, Xi Xie, Simon MingYuen Lee, Yitao Wang, Kam W Leong, Meiwan Chen
Co-delivery of multiple drugs with complementary anticancer mechanisms by nano-carriers offers an effective strategy to treat cancer. The combination of drugs with pro-apoptotic and anti-angiogenic activities is potentially effective in treating human hepatocellular carcinoma (HCC). Herein, we developed a co-delivery system for doxorubicin (Dox), a pro-apoptotic drug, and curcumin (Cur), a potent drug for antiangiogenesis, in pH-sensitive nanoparticles (NPs) constituted with amphiphilic poly(β-amino ester) copolymer...
April 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28357099/spontaneous-regression-of-hepatocellular-carcinoma-in-a-caucasian-male-patient-a-case-report-and-review-of-the-literature
#10
Daniel P Noij, Petrus W G van Der Linden
Hepatocellular carcinoma (HCC) is the most common primary hepatic cancer. As it often presents at an advanced stage, it generally has a poor prognosis. Spontaneous regression is a rare finding in HCC, and is often associated with tumour ischemia or a systemic inflammatory response. We herein present the case of a Caucasian patient with spontaneous regression of advanced HCC, not associated with either mechanism. Our patient was a 74-year old Caucasian male who presented with advanced biopsy-proven HCC, with α-fetoprotein levels of >16,600 kU/l...
February 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28342400/using-gene-expression-database-to-uncover-biology-functions-of-1-4-disubstituted-1-2-3-triazole-analogues-synthesized-via-a-copper-i-catalyzed-reaction
#11
Chun-Li Su, Chia-Ling Tseng, Chintakunta Ramesh, Hsiao-Sheng Liu, Chi-Ying F Huang, Ching-Fa Yao
We have synthesized bioactive 1,4-disubstituted 1,2,3-triazole analogues containing 2H-1,4-benzoxazin-3-(4H)-one derivatives via 1,3-dipolar cycloaddition in the presence of CuI. All the reactions proceeded smoothly and afforded its desired products in excellent yields. Among these analogues, 3y exhibited a better cytotoxic effect on human hepatocellular carcinoma (HCC) Hep 3B cells and displayed less cytotoxicity on normal human umbilical vein endothelial cells, compared with Sorafenib, a targeted therapy for advanced HCC...
May 26, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28338175/study-on-the-mechanism-of-ampk-signaling-pathway-and-its-effect-on-apoptosis-of-human-hepatocellular-carcinoma-smmc-7721-cells-by-curcumin
#12
Y-J Zhang, H Xiang, J-S Liu, D Li, Z-Y Fang, H Zhang
OBJECTIVE: Liver cancer is a common malignant tumor in the digestive system. Curcumin is a kind of phenolic pigment, which is extracted from herbage and has a plenty of physiological roles in anti-inflammation, anti-oxidation and anti-tumor. In our study, human hepatoma SMMC-7721 cell lines were selected and treated with curcumin to detect its effects on the apoptosis and AMPK signaling pathway. MATERIALS AND METHODS: Human liver cancer cell strain SMMC-7721 was cultured and treated with different curcumin concentrations for different times followed by measuring the changes of cell proliferation activity and cycle by MTT and flow cytometry, respectively...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28179291/synergistic-inhibitory-effect-of-traditional-chinese-medicine-astragaloside-iv-and-curcumin-on-tumor-growth-and-angiogenesis-in-an-orthotopic-nude-mouse-model-of-human-hepatocellular-carcinoma
#13
Shuo Zhang, Decai Tang, Wenhua Zang, Gang Yin, Jianguo Dai, Y U Sun, Zhijian Yang, Robert M Hoffman, Xiuxia Guo
AIM: The aim of the present study was to investigate the efficacy of the traditional Chinese medicine (TCM), astragaloside IV (AS-IV) and curcumin on tumor growth and angiogenesis in an orthotopic nude-mouse model of human hepatocellular carcinoma (HCC). We have previously shown the usefulness of orthotopic models of human cancer for evaluation of the efficacy of TCM. MATERIALS AND METHODS: Nude mice with orthotopic HepG2 HCC were treated with vehicle control (0...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28123463/novel-protective-role-of-curcumin-and-taurine-combination-against-experimental-hepatocarcinogenesis
#14
Motawa Eisa El-Houseini, Ibrahim Ali El-Agoza, Mona Mohamed Sakr, Ghada Mohamed El-Malky
Hepatocarcinogenesis is a prerequisite to hepatocellular carcinoma (HCC), which is one of the most common cancers among humans. Therefore, it is important to search for agents that protect against hepatocarcinogenesis. The present study aimed to investigate the protective effects of a combination of taurine and curcumin against experimental hepatocarcinogenesis induced by diethyl nitrosamine (DENA) in a rat model. A total of 100 rats were divided into eight groups. Eight weeks following DENA injection and treatment with curcumin and taurine, the rats were sacrificed to obtain blood and hepatic tissue samples for the evaluation of various markers and histopathological observations...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28110063/curcumin-ameliorates-liver-damage-and-progression-of-nash-in-nash-hcc-mouse-model-possibly-by-modulating-hmgb1-nf-%C3%AE%C2%BAb-translocation
#15
Rejina Afrin, Somasundaram Arumugam, Azizur Rahman, Mir Imam Ibne Wahed, Vengadeshprabhu Karuppagounder, Meilei Harima, Hiroshi Suzuki, Shizuka Miyashita, Kenji Suzuki, Hiroyuki Yoneyama, Kazuyuki Ueno, Kenichi Watanabe
Curcumin, a phenolic compound, has a wide spectrum of therapeutic effects such as antitumor, anti-inflammatory, anti-cancer and so on. The study aimed to investigate the underlying mechanisms of curcumin to protect liver damage and progression of non-alcoholic steatohepatitis (NASH) in a novel NASH-hepatocellular carcinoma (HCC) mouse model. To induce this model neonatal C57BL/6J male mice were exposed to low-dose streptozotocin and were fed a high-fat diet (HFD) from the age of 4weeks to 14weeks. Curcumin was given at 100mg/kg dose daily by oral gavage started at the age of 10weeks and continued until 14weeks along with HFD feeding...
March 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28012169/curcumin-as-a-potential-candidate-for-treating-hyperlipidemia-a-review-of-cellular-and-metabolic-mechanisms
#16
REVIEW
Yunes Panahi, Yasin Ahmadi, Manouchehr Teymouri, Thomas P Johnston, Amirhossein Sahebkar
Curcumin is an herbal polyphenol extensively investigated for antioxidant, anti-inflammatory, and hypolipidaemic properties. In the present review, the efficacy of curcumin for improving a plasma lipid profile has been evaluated and compared with statins, a well-known class of medicines for treating hypercholesterolemia and hyperlipidaemia. Curcumin is presumably most effective in reducing triglyceride (TG), while statins are most efficient in lowering low-density lipoproteins-cholesterol (LDL-C). Additionally, various molecular and metabolic mediators of cholesterol and plasma lipid homeostasis are discussed in relation to how they are modulated by curcumin or statins...
January 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27999817/ef24-suppresses-invasion-and-migration-of-hepatocellular-carcinoma-cells-in-vitro-via-inhibiting-the-phosphorylation-of-src
#17
Ran Zhao, Lamtin Tin, Yuhua Zhang, Yiqi Wu, Yinji Jin, Xiaoming Jin, Fengmin Zhang, Xiaobo Li
Diphenyl difluoroketone (EF24), a curcumin analog, is a promising anticancer compound that exerts its effects by inhibiting cell proliferation and inducing apoptosis. However, the efficacy of EF24 against cancer metastasis, particularly in hepatocellular carcinoma (HCC), remains elusive. In this study, the effect of EF24 on HCCLM-3 and HepG2 cell migration and invasion was detected by wound healing and transwell assay, respectively. The results revealed that EF24 suppressed the migration and invasion of both HCCLM-3 and HepG2 cells...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27895800/a-novel-curcumin-analogue-is-a-potent-chemotherapy-candidate-for-human-hepatocellular-carcinoma
#18
Ji-An Zhao, Mei-Xiang Sang, Cui-Zhi Geng, Shi-Jie Wang, Bao-En Shan
Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel CUR analogue, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63), to be used as a potential therapeutic agent for hepatocellular carcinoma (HCC) in vitro and in vivo. The current study demonstrated that GL63 exhibited more potent inhibition of proliferation of HCC cells than CUR...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27354595/photodynamic-therapy-potentiates-the-effects-of-curcumin-on-pediatric-epithelial-liver-tumor-cells
#19
Verena Ellerkamp, Nicola Bortel, Evi Schmid, Bettina Kirchner, Sorin Armeanu-Ebinger, Jörg Fuchs
BACKGROUND/AIM: Curcumin (CUM) is a promising agent in complementary oncology. The present study analyzed the photoactive properties of curcumin on pediatric epithelial liver tumor cell lines. MATERIALS AND METHODS: Hepatoblastoma cell lines (HuH6, HepT1) and hepatocellular carcinoma cell lines (HepG2, HC-AFW1) were treated with curcumin and exposed to blue light (phototherapy, 480 nm, 300 W). Cell viability (MTT tests), cellular oxidative stress (production of reactive oxygen species (ROS)) and cellular uptake/degradation of curcumin were analyzed...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27274242/vesicular-liposomal-and-nanoparticulated-delivery-of-curcumin-a-comparative-study-on-carbon-tetrachloride-mediated-oxidative-hepatocellular-damage-in-rat-model
#20
COMPARATIVE STUDY
Somsubhra Thakur Choudhury, Nirmalendu Das, Swarupa Ghosh, Debasree Ghosh, Somsuta Chakraborty, Nahid Ali
The liver plays a vital role in biotransforming and extricating xenobiotics and is thus prone to their toxicities. Short-term administration of carbon tetrachloride (CCl4) causes hepatic inflammation by enhancing cellular reactive oxygen species (ROS) level, promoting mitochondrial dysfunction, and inducing cellular apoptosis. Curcumin is well accepted for its antioxidative and anti-inflammatory properties and can be considered as an effective therapeutic agent against hepatotoxicity. However, its therapeutic efficacy is compromised due to its insolubility in water...
2016: International Journal of Nanomedicine
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