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https://www.readbyqxmd.com/read/27895800/a-novel-curcumin-analogue-is-a-potent-chemotherapy-candidate-for-human-hepatocellular-carcinoma
#1
Ji-An Zhao, Mei-Xiang Sang, Cui-Zhi Geng, Shi-Jie Wang, Bao-En Shan
Curcumin (CUR) has been demonstrated to protect against carcinogenesis and to prevent tumor development in cancer; however, the clinical application of CUR is limited by its instability and poor metabolic properties. The present study offers an strategy for a novel CUR analogue, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63), to be used as a potential therapeutic agent for hepatocellular carcinoma (HCC) in vitro and in vivo. The current study demonstrated that GL63 exhibited more potent inhibition of proliferation of HCC cells than CUR...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27354595/photodynamic-therapy-potentiates-the-effects-of-curcumin-on-pediatric-epithelial-liver-tumor-cells
#2
Verena Ellerkamp, Nicola Bortel, Evi Schmid, Bettina Kirchner, Sorin Armeanu-Ebinger, Jörg Fuchs
BACKGROUND/AIM: Curcumin (CUM) is a promising agent in complementary oncology. The present study analyzed the photoactive properties of curcumin on pediatric epithelial liver tumor cell lines. MATERIALS AND METHODS: Hepatoblastoma cell lines (HuH6, HepT1) and hepatocellular carcinoma cell lines (HepG2, HC-AFW1) were treated with curcumin and exposed to blue light (phototherapy, 480 nm, 300 W). Cell viability (MTT tests), cellular oxidative stress (production of reactive oxygen species (ROS)) and cellular uptake/degradation of curcumin were analyzed...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27274242/vesicular-liposomal-and-nanoparticulated-delivery-of-curcumin-a-comparative-study-on-carbon-tetrachloride-mediated-oxidative-hepatocellular-damage-in-rat-model
#3
Somsubhra Thakur Choudhury, Nirmalendu Das, Swarupa Ghosh, Debasree Ghosh, Somsuta Chakraborty, Nahid Ali
The liver plays a vital role in biotransforming and extricating xenobiotics and is thus prone to their toxicities. Short-term administration of carbon tetrachloride (CCl4) causes hepatic inflammation by enhancing cellular reactive oxygen species (ROS) level, promoting mitochondrial dysfunction, and inducing cellular apoptosis. Curcumin is well accepted for its antioxidative and anti-inflammatory properties and can be considered as an effective therapeutic agent against hepatotoxicity. However, its therapeutic efficacy is compromised due to its insolubility in water...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27266713/nutritional-epigenetics-and-the-prevention-of-hepatocellular-carcinoma-with-bioactive-food-constituents
#4
Fernando Salvador Moreno, Renato Heidor, Igor P Pogribny
Hepatocellular carcinoma (HCC) is an aggressive and life-threatening disease often diagnosed at intermediate or advanced stages, which substantially limits therapeutic approaches to its successful treatment. This indicates that the prevention of HCC may be the most promising strategy in reducing its incidence and mortality. Emerging evidence indicates that numerous nutrients and nonnutrient dietary bioactive components can reduce the occurrence and/or delay the development of HCC through modifications of deregulated epigenetic mechanisms...
July 2016: Nutrition and Cancer
https://www.readbyqxmd.com/read/27234697/dendrosomal-curcumin-nanoformulation-modulate-apoptosis-related-genes-and-protein-expression-in-hepatocarcinoma-cell-lines
#5
Maryam Montazeri, Majid Sadeghizadeh, Yones Pilehvar-Soltanahmadi, Faraz Zarghami, Samaneh Khodi, Mina Mohaghegh, Hadi Sadeghzadeh, Nosratollah Zarghami
The side-effects observed in conventional therapies have made them unpromising in curing Hepatocellular carcinoma; therefore, developing novel treatments can be an overwhelming significance. One of such novel agents is curcumin which can induce apoptosis in various cancerous cells, however, its poor solubility is restricted its application. To overcome this issue, this paper employed dendrosomal curcumin (DNC) was employed to in prevent hepatocarcinoma in both RNA and protein levels. Hepatocarcinoma cells, p53 wild-type HepG2 and p53 mutant Huh7, were treated with DNC and investigated for toxicity study using MTT assay...
July 25, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27165229/evaluation-of-mir-34-family-and-dna-methyltransferases-1-3a-3b-gene-expression-levels-in-hepatocellular-carcinoma-following-treatment-with-dendrosomal-nanocurcumin
#6
Fatemeh Chamani, Majid Sadeghizadeh, Mahbobeh Masoumi, Sadegh Babashah
Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver making up more than 80 percent of cases. It is known to be the sixth most prevalent cancer and the third most frequent cause of cancer related death worldwide. Epigenetic regulation constitutes an important mechanism by which dietary components can selectively activate or inactivate target gene expression. The miR-34 family members including mir-34a, mir-34b and mir-34c are tumor suppressor micro RNAs, which are expressed in the majority of normal tissues...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27043533/hepatoprotective-effects-of-chinese-medicinal-herbs-a-focus-on-anti-inflammatory-and-anti-oxidative-activities
#7
REVIEW
Puiyan Lam, Fan Cheung, Hor Yue Tan, Ning Wang, Man Fung Yuen, Yibin Feng
The liver is intimately connected to inflammation, which is the innate defense system of the body for removing harmful stimuli and participates in the hepatic wound-healing response. Sustained inflammation and the corresponding regenerative wound-healing response can induce the development of fibrosis, cirrhosis and eventually hepatocellular carcinoma. Oxidative stress is associated with the activation of inflammatory pathways, while chronic inflammation is found associated with some human cancers. Inflammation and cancer may be connected by the effect of the inflammation-fibrosis-cancer (IFC) axis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26900700/functional-rescue-of-trafficking-impaired-abcb4-mutants-by-chemical-chaperones
#8
Raquel Gordo-Gilart, Sara Andueza, Loreto Hierro, Paloma Jara, Luis Alvarez
Multidrug resistance protein 3 (MDR3, ABCB4) is a hepatocellular membrane protein that mediates biliary secretion of phosphatidylcholine. Null mutations in ABCB4 gene give rise to severe early-onset cholestatic liver disease. We have previously shown that the disease-associated mutations p.G68R, p.G228R, p.D459H, and p.A934T resulted in retention of ABCB4 in the endoplasmic reticulum, thus failing to target the plasma membrane. In the present study, we tested the ability of two compounds with chaperone-like activity, 4-phenylbutyrate and curcumin, to rescue these ABCB4 mutants by assessing their effects on subcellular localization, protein maturation, and phospholipid efflux capability...
2016: PloS One
https://www.readbyqxmd.com/read/26707143/curcumin-enhances-the-antitumor-effect-of-abt-737-via-activation-of-the-ros-ask1-jnk-pathway-in-hepatocellular-carcinoma-cells
#9
Ruinian Zheng, Zhijian You, Jun Jia, Shunhuan Lin, Shuai Han, Aixue Liu, Huidong Long, Senming Wang
At present, the therapeutic treatment strategies for patients with hepatocellular carcinoma (HCC) remain unsatisfactory, and novel methods are urgently required to treat this disease. Members of the B cell lymphoma (Bcl)-2 family are anti‑apoptotic proteins, which are commonly expressed at high levels in certain HCC tissues and positively correlate with the treatment resistance of patients with HCC. ABT-737, an inhibitor of Bcl-2 anti-apoptotic proteins, has been demonstrated to exhibit potent antitumor effects in several types of tumor, including HCC...
February 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26633344/synthesis-and-biological-evaluation-of-curcumin-derivatives-with-water-soluble-groups-as-potential-antitumor-agents-an-in-vitro-investigation-using-tumor-cell-lines
#10
Luyang Ding, Shuli Ma, Hongxiang Lou, Longru Sun, Mei Ji
Three series of curcumin derivatives including phosphorylated, etherified, and esterified products of curcumin were synthesized, and their anti-tumor activities were assessed against human breast cancer MCF-7, hepatocellular carcinoma Hep-G2, and human cervical carcinoma HeLa cells. Compared with curcumin, compounds 3, 8, and 9 exhibited stronger antitumor cell line growth activities against HeLa cells. Compound 12 also showed higher antitumor cell line growth activities on MCF-7 cells than curcumin. Among them, 4-((1E,6E)-7-(4-Hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-dienyl)-2-methoxyphenyl dihydrogen phosphate(3) showed the strongest activity with an half maximal inhibitory concentration (IC50) of 6...
2015: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26609559/curcumin-inhibits-activation-of-trpm2-channels-in-rat-hepatocytes
#11
E Kheradpezhouh, G J Barritt, G Y Rychkov
Oxidative stress is a hallmark of many liver diseases including viral and drug-induced hepatitis, ischemia-reperfusion injury, and non-alcoholic steatohepatitis. One of the consequences of oxidative stress in the liver is deregulation of Ca(2+) homeostasis, resulting in a sustained elevation of the free cytosolic Ca(2+) concentration ([Ca(2+)]c) in hepatocytes, which leads to irreversible cellular damage. Recently it has been shown that liver damage induced by paracetamol and subsequent oxidative stress is, in large part, mediated by Ca(2+) entry through Transient Receptor Potential Melastatin 2 (TRPM2) channels...
April 2016: Redox Biology
https://www.readbyqxmd.com/read/26585812/curcumin-suppresses-phthalate-induced-metastasis-and-the-proportion-of-cancer-stem-cell-csc-like-cells-via-the-inhibition-of-ahr-erk-sk1-signaling-in-hepatocellular-carcinoma
#12
Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Kung-Kai Kuo, Hua-Lin Wu, Chien-Chih Chiu, Eing-Mei Tsai, Po-Lin Kuo
Recent evidence indicating that phthalates promote cancer development, including cell proliferation, migration, and invasion, has raised public health concerns. Here, we show that bis(2-ethylhexyl) phthalate promotes the migration, invasion, and epithelial-mesenchymal transition of hepatocellular carcinoma cells. In addition, bis(2-ethylhexyl) phthalate increased the proportion of cancer stem cell (CSC)-like cells and stemness maintenance in vitro as well as tumor growth and metastasis in vivo. The various activities of curcumin, including anticancer, anti-inflammation, antioxidation, and immunomodulation, have been investigated extensively...
December 9, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/26539482/curcumin-sensitizes-hepatocellular-carcinoma-cells-to-radiation-via-suppression-of-radiation-induced-nf-%C3%AE%C2%BAb-activity
#13
Fei-Ting Hsu, Yu-Chang Liu, Tsu-Te Liu, Jeng-Jong Hwang
The effects and possible underlying mechanism of curcumin combined with radiation in human hepatocellular carcinoma (HCC) cells in vitro were evaluated. The effects of curcumin, radiation, and combination of both on cell viability, apoptosis, NF-κB activation, and expressions of NF-κB downstream effector proteins were investigated with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), NF-κB reporter gene, mitochondrial membrane potential (MMP), electrophoretic mobility shift (EMSA), and Western blot assays in Huh7-NF-κB-luc2, Hep3B, and HepG2 cells...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26458588/the-role-of-the-vascular-endothelial-growth-factor-vascular-endothelial-growth-factor-receptors-axis-mediated-angiogenesis-in-curcumin-loaded-nanostructured-lipid-carriers-induced-human-hepg2-cells-apoptosis
#14
Fengling Wang, Zhengmin He, Wenting Dai, Qi Li, Xiuzhen Liu, Zhengsheng Zhang, Dandan Zhai, Jin Chen, Weidong Chen
BACKGROUND: Curcumin (diferuloylmethane), the active constituent of turmeric extract has potent anti-cancer properties have been demonstrated in hepatocellular carcinoma (HCC). However, its underlying molecular mechanism of therapeutic effects remains unclear. Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have crucial roles in tumor angiogenesis. PURPOSE: The goal of this study was to investigate the role of the VEGF/VEGFRs mediated angiogenesis during the proliferation and apoptosis of human HepG2 hepatoma cell line and the effect of curcumin-loaded nanostructured lipid carriers (Cur-NLC)...
July 2015: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/26457982/curcumin-silybin-phytosome-%C3%A2-and-%C3%AE-r-lipoic-acid-mitigate-chronic-hepatitis-in-rat-by-inhibiting-oxidative-stress-and-inflammatory-cytokines-production
#15
Shimaa O Ali, Hebatallah A Darwish, Nabila A Ismail
Chronic hepatitis is recognized as a worldwide health problem that gradually progresses towards cirrhosis and hepatocellular carcinoma. Despite the large number of experiments using animal models for allergic hepatitis, it is still difficult to produce a picture of chronic hepatitis. Therefore, this study was conducted to introduce an animal model approximating to the mechanism of chronicity in human hepatitis. The study also aimed to examine the hepatoprotective effects of curcumin, silybin phytosome(®) and α-R-lipoic acid against thioacetamide (TAA)-induced chronic hepatitis in rat model...
May 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/26436447/natural-antioxidants-for-non-alcoholic-fatty-liver-disease-molecular-targets-and-clinical-perspectives
#16
REVIEW
Federico Salomone, Justyna Godos, Shira Zelber-Sagi
Non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD), is emerging as a main health problem in industrialized countries. Lifestyle modifications are effective in the treatment of NAFLD; however, the long-term compliance is low. Therefore, several pharmacological treatments have been proposed but none has shown significant efficacy or long-term safety. Natural polyphenols are a heterogeneous class of polyphenolic compounds contained in vegetables, which are being proposed for the treatment of different metabolic disorders...
January 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26428113/gum-arabic-curcumin-conjugate-micelles-with-enhanced-loading-for-curcumin-delivery-to-hepatocarcinoma-cells
#17
P R Sarika, Nirmala Rachel James, P R Anil Kumar, Deepa K Raj, T V Kumary
Curcumin is conjugated to gum arabic, a highly water soluble polysaccharide to enhance the solubility and stability of curcumin. Conjugation of curcumin to gum arabic is confirmed by (1)H NMR, fluorescence and UV spectroscopy studies. The conjugate self assembles to spherical nano-micelles (270 ± 5 nm) spontaneously, when dispersed in aqueous medium. Spherical morphology of the self assembled conjugate is evidenced by field emission scanning electron microscopy and transmission electron microscopy. The self assembly of the amphiphilic conjugate into micelle in aqueous medium significantly enhances the solubility (900 fold of that of free curcumin) and stability of curcumin in physiological pH...
December 10, 2015: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26409325/novel-carbocyclic-curcumin-analog-cur3d-modulates-genes-involved-in-multiple-apoptosis-pathways-in-human-hepatocellular-carcinoma-cells
#18
Khushwant S Bhullar, Amitabh Jha, H P Vasantha Rupasinghe
Anticancer activity of a novel curcumin analog (E)-2-(4-hydroxy-3-methoxybenzylidene)-5-((E)-3-(4-hydroxy-3-methoxyphenyl)acryloyl)cyclopentanone (CUR3d) was studied using a human hepatocellular carcinoma cell line (HepG2). The results showed that CUR3d completely inhibits the tumor cell proliferation in a dose- and time-dependent manner. CUR3d at 100 μmol/L activated the pro-apoptotic caspase-3 along with downregulation of anti-apoptotic BIRC5 and Bcl2. CUR3d treatment controlled the cancer cell growth by downregulating the expression of PI3K/Akt (Akt1, Akt2) pathway along with NF-κB...
December 5, 2015: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26278679/synergistic-effect-of-curcumin-and-piperine-in-suppression-of-dena-induced-hepatocellular-carcinoma-in-rats
#19
Vikram Patial, Mahesh S, Supriya Sharma, Kunal Pratap, Damanpreet Singh, Yogendra S Padwad
Curcumin has been reported to suppress different types of clinical and experimentally-induced tumors, but due to less absorption and quick metabolism it show poor bioavailability. The present study was envisaged to investigate the possible synergistic effect of combined treatment of curcumin with piperine in suppression of diethylnitrosamine (DENA)-induced hepatocellular carcinoma (HCC) in rats, owing to permeability enhancing effect of latter. HCC was induced by supplying DENA (0.01%) in drinking water for 10 weeks...
September 2015: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/26163620/implications-of-sex-hormone-receptor-gene-expression-in-the-predominance-of-hepatocellular-carcinoma-in-males-role-of-natural-products
#20
Hanaa H Ahmed, Wafaa Gh Shousha, Aziza B Shalby, Hatem A El-Mezayen, Nora N Ismaiel, Nadia S Mahmoud
The present study was planned to investigate the role of sex hormone receptor gene expression in the pathogenesis of hepatocellular carcinoma (HCC). Adult male Wistar rats were divided into seven groups. Group (1) was negative control. Groups (2), (5), (6), and (7) were orally administered with N-nitrosodiethylamine for the induction of HCC, then group (2) was left untreated, group (5) was orally treated with curcumin, group (6) was orally treated with carvacrol, and group (7) was intraperitoneally injected with doxorubicin, whereas groups (3) and (4) were orally administered only curcumin and carvacrol, respectively...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
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