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https://www.readbyqxmd.com/read/28928446/tumour-derived-pgd2-and-nkp30-b7h6-engagement-drives-an-immunosuppressive-ilc2-mdsc-axis
#1
Sara Trabanelli, Mathieu F Chevalier, Amaia Martinez-Usatorre, Alejandra Gomez-Cadena, Bérengère Salomé, Mariangela Lecciso, Valentina Salvestrini, Grégory Verdeil, Julien Racle, Cristina Papayannidis, Hideaki Morita, Irene Pizzitola, Camille Grandclément, Perrine Bohner, Elena Bruni, Mukul Girotra, Rani Pallavi, Paolo Falvo, Elisabeth Oppliger Leibundgut, Gabriela M Baerlocher, Carmelo Carlo-Stella, Daniela Taurino, Armando Santoro, Orietta Spinelli, Alessandro Rambaldi, Emanuela Giarin, Giuseppe Basso, Cristina Tresoldi, Fabio Ciceri, David Gfeller, Cezmi A Akdis, Luca Mazzarella, Saverio Minucci, Pier Giuseppe Pelicci, Emanuela Marcenaro, Andrew N J McKenzie, Dominique Vanhecke, George Coukos, Domenico Mavilio, Antonio Curti, Laurent Derré, Camilla Jandus
Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction of CRTH2 and NKp30 with elevated tumour-derived PGD2 and B7H6, respectively. ILC2s, in turn, activate monocytic myeloid-derived suppressor cells (M-MDSCs) via IL-13 secretion. Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28927846/cost-effectiveness-assessment-in-outpatient-sinonasal-surgery
#2
G Mortuaire, D Theis, R Fackeure, D Chevalier, I Gengler
AIMS: To assess the cost-effectiveness of outpatient sinonasal surgery in terms of clinical efficacy and control of expenses. METHODS: A retrospective study was conducted from January 2014 to January 2016. Patients scheduled for outpatient sinonasal surgery were systematically included. Clinical data were extracted from surgical and anesthesiology computer files. The cost accounting methods applied in our institution were used to evaluate logistic and technical costs...
September 15, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28903188/hair-on-hair-static-friction-coefficient-can-be-determined-by-tying-a-knot
#3
Nicolas R Chevalier
Characterizing the tribological properties of the hair-hair interface is important to quantify the manageability of hair and to assess the performance of hair care products. Audoly et al. (Phys. Rev. Lett. 99, 164301, 2007) derived an equation relating the self-friction coefficient of an elastic fiber to the dimensions of a simple, relaxed overhand knot made from this fiber. I experimentally tested and validated their equation using nylon thread and an independent measurement of its self-friction coefficient...
September 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28895012/biologic-agents-are-associated-with-excessive-weight-gain-in-children-with-inflammatory-bowel-disease
#4
Leonard Haas, Rachel Chevalier, Brittny T Major, Felicity Enders, Seema Kumar, Jeanne Tung
BACKGROUND: Children with active inflammatory bowel disease (IBD) are frequently underweight. Anti-tumor necrosis factor (anti-TNF) agents may induce remission and restore growth. However, its use in other autoimmune diseases has been associated with excess weight gain. Our aim was to examine whether children with IBD could experience excess weight gain. METHODS: A centralized diagnostic index identified pediatric IBD patients evaluated at our institution who received anti-TNF therapy for at least 1 year between August 1998 and December 2013...
September 11, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28892277/ungulates-increase-forest-plant-species-richness-to-the-benefit-of-non-forest-specialists
#5
Vincent Boulanger, Jean-Luc Dupouey, Frédéric Archaux, Vincent Badeau, Christophe Baltzinger, Richard Chevalier, Emmanuel Corcket, Yann Dumas, Françoise Forgeard, Anders Mårell, Pierre Montpied, Yoan Paillet, Jean-François Picard, Sonia Saïd, Erwin Ulrich
Large wild ungulates are a major biotic factor shaping plant communities. They influence species abundance and occurrence directly by herbivory and plant dispersal, or indirectly by modifying plant-plant interactions and through soil disturbance. In forest ecosystems, researchers' attention has been mainly focused on deer overabundance. Far less is known about the effects on understory plant dynamics and diversity of wild ungulates where their abundance is maintained at lower levels to mitigate impacts on tree regeneration...
September 11, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28881045/diagnostic-accuracy-of-immunofluorescence-versus-immunoperoxidase-staining-to-distinguish-immune-complex-mediated-glomerulonephritis-and-c3-dominant-glomerulopathy
#6
Yassine Bouatou, Jesper Kers, Marie S N Chevalier-Florquin, Nike Claessen, Tri Q Nguyen, Jeffrey Damman, Henrique Proença, Joris J T H Roelofs, Sandrine Florquin
AIMS: Membranoproliferative glomerulonephritis (MPGN) has been reclassified from an electron microscopy to an immunofluorescence (IF) based semi quantitative classification with immunoperoxidase (IP) technique as a backup option when IF is not possible. However, no data are available on the interobserver variability, the correlation and the reclassification of MPGN based on these two techniques. METHODS & RESULTS: We retrospectively analyzed cases of type 1 MPGN...
September 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28875562/a-new-composite-hydrogel-combining-the-biological-properties-of-collagen-with-the-mechanical-properties-of-a-supramolecular-scaffold-for-bone-tissue-engineering
#7
Mathieu Maisani, Sophia Ziane, Camille Ehret, Lucie Levesque, Robin Siadous, Jean-François Le Meins, Pascale Chevalier, Philippe Barthélémy, Hugo De Oliveira, Joëlle Amédée, Diego Mantovani, Olivier Chassande
Tissue engineering is a promising alternative to autografts, allografts or biomaterials to address the treatment of severe and large bone lesions. Classically, tissue engineering products associate a scaffold and cells, and are implanted or injected into the lesion. These cells must be embedded in an appropriate biocompatible scaffold, which offers a favourable environment for their survival and differentiation. Here, we designed a composite hydrogel composed of collagen I, an extracellular matrix protein widely used in several therapeutic applications, which we associated with a physical hydrogel generated from a synthetic small amphiphilic molecule...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28873300/cryogenic-photochemical-synthesis-and-electronic-spectroscopy-of-cyanotetracetylene
#8
Urszula Szczepaniak, Robert Kolos, Marcin Gronowski, Michele Chevalier, Jean-Claude Guillemin, Michal Turowski, Thomas Gage Custer, Claudine Crepin
HC9N is a molecule of astrochemical interest. In this study, it was produced in cryogenic Ar and Kr matrices from UV-photolyzed diacetylene/cyanodiacetylene mixtures. Its strong phosphorescence was discovered and served for the identification of the compound. Vibrationally-resolved phosphorescence excitation spectra gave insight into excited singlet electronic states. Two electronic systems were observed: around 26 000 - 34 000 cm(-1) and 35 000 - 50 000 cm(-1). Energies of the second excited singlet and the lowest triplet state were derived from analysis of these systems...
September 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28868953/preparation-characterization-and-in-vitro-evaluation-of-%C3%AE%C2%B5-polylysine-loaded-polymer-blend-microparticles-for-potential-pancreatic-cancer-therapy
#9
Merari T Chevalier, Mónica C García, Daniela Gonzalez, Sandro M Gomes-Filho, Daniela S Bassères, Hernan Farina, Vera A Alvarez
Peptide active ingredients show great promise regarding the treatment of various health-endangering diseases. It is reported that L-lysine inhibits the proliferation of several tumour lines in vitro and in vivo. However, proteins and peptide drugs possess certain disadvantages such as in vivo instability and short biological half-life. On the grounds that drug delivery systems can overcome a wide spectrum of bioactive compounds issues, a biopolymeric blend-based microparticulated system capable of delivering ε-polylysine (PLL) was developed...
September 3, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28866583/supporting-handoff-in-asynchronous-collaborative-sensemaking-using-knowledge-transfer-graphs
#10
Jian Zhao, Michael Glueck, Petra Isenberg, Fanny Chevalier, Azam Khan
During asynchronous collaborative analysis, handoff of partial findings is challenging because externalizations produced by analysts may not adequately communicate their investigative process. To address this challenge, we developed techniques to automatically capture and help encode tacit aspects of the investigative process based on an analyst's interactions, and streamline explicit authoring of handoff annotations. We designed our techniques to mediate awareness of analysis coverage, support explicit communication of progress and uncertainty with annotation, and implicit communication through playback of investigation histories...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28866570/phenolines-phenotype-comparison-visualizations-for-disease-subtyping-via-topic-models
#11
Michael Glueck, Mahdi Pakdaman Naeini, Finale Doshi-Velez, Fanny Chevalier, Azam Khan, Daniel Wigdor, Michael Brudno
PhenoLines is a visual analysis tool for the interpretation of disease subtypes, derived from the application of topic models to clinical data. Topic models enable one to mine cross-sectional patient comorbidity data (e.g., electronic health records) and construct disease subtypes-each with its own temporally evolving prevalence and co-occurrence of phenotypes-without requiring aligned longitudinal phenotype data for all patients. However, the dimensionality of topic models makes interpretation challenging, and de facto analyses provide little intuition regarding phenotype relevance or phenotype interrelationships...
August 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28865693/-therapeutic-education-program-on-stroke-for-prevention-of-the-vascular-risk-in-women
#12
Corinne Chevalier, Pascale Raclot, Lou Augustyniak, Marie-Ange Salisson, Magali Bougardane, Maurice Giroud, Yannick Béjot
Stroke is a disease whose frequency is increasing especially in women and in the elderly, and that is associated with major functional impairment with adverse consequences in terms of quality of life. Implementation of a therapeutic education program is helpful for patients and their relatives so as to acquire skills to manage their own health, with the goal of reducing recurrences and improving personal experience of the disease.
August 2017: Revue de L'infirmière
https://www.readbyqxmd.com/read/28865343/formation-of-peptide-layers-and-adsorption-mechanisms-on-a-negatively-charged-cation-exchange-membrane
#13
Mathieu Persico, Sergey Mikhaylin, Alain Doyen, Loubna Firdaous, Riadh Hammami, Mickaël Chevalier, Christophe Flahaut, Pascal Dhulster, Laurent Bazinet
Polypeptide/solid charged surface interactions are omnipresent in the biomedical and biochemical fields. The present study aimed to understand the adsorption mechanisms of a cation-exchange membrane (CEM) by a well-characterized peptide mixture at three different pH values. Results demonstrated that fouling was important at pH 6, twice lower at pH 2 and negligible at pH 10. At pH 6, ALPMHIR and TKIPAVFK sequences firstly established electrostatic interactions with the negative CEM charges (SO3(-)) through their positive K and R residues (NH3(+)) creating a first nanolayer...
August 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28861245/herbivore-grazing-or-trampling-trampling-effects-by-a-large-ungulate-in-cold-high-latitude-ecosystems
#14
Jan Heggenes, Arvid Odland, Tomas Chevalier, Jörgen Ahlberg, Amanda Berg, Håkan Larsson, Dag K Bjerketvedt
Mammalian herbivores have important top-down effects on ecological processes and landscapes by generating vegetation changes through grazing and trampling. For free-ranging herbivores on large landscapes, trampling is an important ecological factor. However, whereas grazing is widely studied, low-intensity trampling is rarely studied and quantified. The cold-adapted northern tundra reindeer (Rangifer tarandus) is a wide-ranging keystone herbivore in large open alpine and Arctic ecosystems. Reindeer may largely subsist on different species of slow-growing ground lichens, particularly in winter...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28845730/organizational-and-managerial-resources-and-quality-of-care-in-french-pediatric-oncology-nursing
#15
Séverine Chevalier, Julien Lejeune, Evelyne Fouquereau, Hélène Coillot, Nicolas Gillet, Virginie Gandemer, Jean Michon, Philippe Colombat
The purpose of this study was to examine the relationships between nurses' organizational and managerial resources (ie, perceived organizational support and transformational leadership) and their quality of patient care, and second, the mediating role of job satisfaction in these relationships. Participants were 510 nurses from 25 out of 29 French pediatric oncology units. Structural equation modeling results revealed that perceived organizational support and transformational leadership were related to nurses' perceived quality of care and that job satisfaction acted as a mediator between these 2 antecedents (ie, organizational and managerial determinants) and this outcome (ie, quality of care)...
August 1, 2017: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/28845468/evolutionary-nephrology
#16
Robert L Chevalier
Progressive kidney disease follows nephron loss, hyperfiltration, and incomplete repair, a process described as "maladaptive." In the past 20 years, a new discipline has emerged that expands research horizons: evolutionary medicine. In contrast to physiologic (homeostatic) adaptation, evolutionary adaptation is the result of reproductive success that reflects natural selection. Evolutionary explanations for physiologically maladaptive responses can emerge from mismatch of the phenotype with environment or evolutionary tradeoffs...
May 2017: KI Reports
https://www.readbyqxmd.com/read/28845242/a46%C3%A2-mers-cov-in-arabian-camels-in-africa-and-central-asia
#17
Daniel K W Chu, Samuel M S Chan, Ranawaka A P M Perera, Eve Miguel, F Roger, V Chevalier, Leo L M Poon, Malik Peiris
No abstract text is available yet for this article.
March 2017: Virus Evolution
https://www.readbyqxmd.com/read/28840803/isolation-and-full-genome-sequences-of-japanese-encephalitis-virus-genotype-i-strains-from-cambodian-human-patients-mosquitoes-and-pigs
#18
Veasna Duong, Rithy Choeung, Christopher Gorman, Denis Laurent, Yoann Crabol, Channa Mey, Borin Peng, Juliette Di Francesco, Vibol Hul, Heng Sothy, Ky Santy, Beat Richner, Jean-David Pommier, San Sorn, Véronique Chevalier, Philippe Buchy, Xavier de Lamballerie, Julien Cappelle, Paul Francis Horwood, Philippe Dussart
Japanese encephalitis remains the most important cause of viral encephalitis in humans in several southeast Asian countries, including Cambodia, causing at least 65 000 cases of encephalitis per year. This vector-borne viral zoonosis - caused by Japanese encephalitis virus (JEV) - is considered to be a rural disease and is transmitted by mosquitoes, with birds and pigs being the natural reservoirs, while humans are accidental hosts. In this study we report the first two JEV isolations in Cambodia from human encephalitis cases from two studies on the aetiology of central nervous system disease, conducted at the two major paediatric hospitals in the country...
September 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28826789/environmental-endocrine-disruptors-new-diabetogens
#19
Patrick Fénichel, Nicolas Chevalier
The prevalence of type-2 diabetes has dramatically increased worldwide during the last few decades. While lifestyle factors (sedentariness, noxious food), together with genetic susceptibility, are well-known actors, there is accumulating evidence suggesting that endocrine disrupting chemicals (EDCs) may also play a pathophysiological role in the occurrence of metabolic diseases. Both experimental and epidemiological evidence support a role for early and chronic exposure to low doses of chemical pollutants with endocrine and metabolic disrupting effects...
August 18, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/28818320/-use-of-a-delphi-survey-to-assess-the-hospital-economic-impact-of-innovative-products-the-example-of-idarucizumab-a-dabigatran-specific-reversal-agent
#20
N Jamet, A P Thivilliers, P Paubel, D Chevalier, S Bourguignon, Y Bézie
OBJECTIVES: The economic impact of therapeutic innovations on the hospital patient management cannot be easily estimated. The objective of this study is to illustrate the use of a Delphi survey as a support tool to identify the changes following the use of idarucizumab in dabigatran-treated patients with uncontrolled/life-threatening bleeding or who required emergency surgery/urgent procedures. METHODS: The Delphi questionnaires have been administrated to 8 emergency physicians or anesthetists from 6 different hospital centers...
August 14, 2017: Annales Pharmaceutiques Françaises
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