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https://www.readbyqxmd.com/read/28222167/emergence-and-development-of-gut-motility-in-the-chicken-embryo
#1
N R Chevalier, V Fleury, S Dufour, V Proux-Gillardeaux, A Asnacios
The gastrointestinal tract transports the food bolus by peristalsis. Gut motility starts at an early age in the developing embryo, well before it is required for nutrition of the organism. We present a comprehensive kinematic study of the emergence and physiological development of gut motility in all regions of the lower digestive tract of the chicken embryo from embryonic days E5 through E9. We characterized motility emergence time, propagation patterns, speed, frequency and amplitude of peristalsis waves...
2017: PloS One
https://www.readbyqxmd.com/read/28214549/atp-dependent-activity-and-mitochondrial-localization-of-drug-efflux-pumps-in-doxorubicin-resistant-breast-cancer-cells
#2
Julie Dartier, Elsa Lemaitre, Igor Chourpa, Caroline Goupille, Stéphane Servais, Stéphan Chevalier, Karine Mahéo, Jean-François Dumas
BACKGROUND: We hypothesized that, among the mechanisms of drug-resistance acquired by doxorubicin (DOX)-resistant breast cancer cells to maintain cell survival, ATP-dependent drug efflux pumps could be expressed in their mitochondrial membranes and this might limit the accumulation of DOX in this subcellular compartment in relation to mitochondrial ATP production. Methods/results Mitochondrial DOX accumulation: the presence and the activity of mitochondrial efflux pumps and their relationship with mitochondrial ATP synthesis were analyzed in DOX-resistant (MCF-7dox(R)) and -sensitive (MCF-7(S)) breast cancer cells...
February 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28214227/automated-breast-density-computation-in-digital-mammography-and-digital-breast-tomosynthesis-influence-on-mean-glandular-dose-and-birads-density-categorization
#3
Maria Castillo-García, Margarita Chevalier, Julia Garayoa, Alejandro Rodriguez-Ruiz, Diego García-Pinto, Julio Valverde
RATIONALE AND OBJECTIVES: The study aimed to compare the breast density estimates from two algorithms on full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) and to analyze the clinical implications. MATERIALS AND METHODS: We selected 561 FFDM and DBT examinations from patients without breast pathologies. Two versions of a commercial software (Quantra 2D and Quantra 3D) calculated the volumetric breast density automatically in FFDM and DBT, respectively...
February 14, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28214070/microbiote-intestinal%C3%A2-qu%C3%A2-en-attendre-au-plan-physiologique-et-th%C3%A3-rapeutique%C3%A2
#4
Joël Doré, Marie-Christine Multon, Jehan-Michel Béhier, Hervé Affagard, Antoine Andremont, Philippe Barthélémy, Rui Batista, Marc Bonneville, Christophe Bonny, Gwendoline Boyaval, Mathias Chamaillard, Marie-Pierre Chevalier, Magali Cordaillat-Simmons, Fabienne Cournarie, Isabelle Diaz, Elisabeth Guillaume, Cyril Guyard, Evelyne Jouvin-Marche, François-Pierre Martin, David Petiteau
No abstract text is available yet for this article.
January 11, 2017: Thérapie
https://www.readbyqxmd.com/read/28211136/from-prioritizing-objects-to-prioritizing-cues-a-developmental-shift-for-cognitive-control
#5
Nicolas Chevalier, Bruno Dauvier, Agnès Blaye
Emerging cognitive control supports increasingly adaptive behaviors and predicts life success, while low cognitive control is a major risk factor during childhood. It is therefore essential to understand how it develops. The present study provides evidence for an age-related shift in the type of information that children prioritize in their environment, from objects that can be directly acted upon to cues signaling how to act. Specifically, gaze patterns recorded while 3- to 12-year-olds and adults engaged in a cognitive control task showed that whereas younger children fixated on targets that they needed to respond to before gazing at task cues signaling how to respond, older children and adults showed the opposite pattern (which yielded better performance)...
February 16, 2017: Developmental Science
https://www.readbyqxmd.com/read/28209261/the-feasibility-of-transcatheter-aortic-valve-implantation-using-the-edwards-sapien-3-for-patients-with-severe-bicuspid-aortic-stenosis
#6
Takahide Arai, Thierry Lefèvre, Thomas Hovasse, Marie-Claude Morice, Mauro Romano, Hakim Benamer, Philippe Garot, Kentaro Hayashida, Erik Bouvier, Bernard Chevalier
BACKGROUND: There are currently only limited data focusing on transcatheter aortic valve implantation (TAVI) for bicuspid aortic valves (BAV) patients using the Edwards SAPIEN (Irvine, CA, USA) 3 (S3) valve. The aim of this study was to evaluate the feasibility and efficacy of TAVI using the S3 in patients with BAV. METHODS: A total of 153 TAVI cases performed with the S3 were included. BAV was detected by multidetector computed tomography (MDCT) in 10 (7%) patients...
February 10, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28207586/open-partial-laryngectomy-after-failure-of-chemo-radiation-indications-oncologic-and-functional-outcomes
#7
Geoffrey Mortuaire, Dominique Chevalier, François Mouawad
PURPOSE OF REVIEW: Early-stage squamous cell carcinoma of the larynx can be successfully treated with radiotherapy or surgery (transoral or open approaches). Oncologic results are comparable while functional results may be different according to the volume of resection. In some countries radiotherapy is often preferred as primary treatment. In case of recurrence, surgical salvage is the only option. Careful examination, endoscopic assessment, computed tomography or magnetic resonance imaging are necessary to assess superficial and deep extensions into the larynx, including cartilage framework and to restage the tumor...
February 15, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28197393/preclinical-efficacy-and-safety-of-the-ty21a-vaccine-strain-for-intravesical-immunotherapy-of-non-muscle-invasive-bladder-cancer
#8
Sonia Domingos-Pereira, Valérie Cesson, Mathieu F Chevalier, Laurent Derré, Patrice Jichlinski, Denise Nardelli-Haefliger
Intravesical Bacillus-Calmette-Guérin (BCG) immunotherapy can reduce recurrence/progression of non-muscle-invasive bladder cancer (NMIBC), although significant adverse events and treatment failure argue for alternative options. Here, we examined whether another attenuated live vaccine, Vivotif/Ty21a, used since more than 30 y against typhoid fever, may be safely used intravesically to improve bladder-tumor treatment. Mice-bearing MB49 orthotopic bladder-tumors treated with intravesical Ty21a or BCG were compared for survival and bacteria recovery...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28194136/substance-p-and-calcitonin-gene-related-peptide-key-regulators-of-cutaneous-microbiota-homeostasis
#9
REVIEW
Awa N'Diaye, Andrei Gannesen, Valérie Borrel, Olivier Maillot, Jeremy Enault, Pierre-Jean Racine, Vladimir Plakunov, Sylvie Chevalier, Olivier Lesouhaitier, Marc G J Feuilloley
Neurohormones diffuse in sweat and epidermis leading skin bacterial microflora to be largely exposed to these host factors. Bacteria can sense a multitude of neurohormones, but their role in skin homeostasis was only investigated recently. The first study focused on substance P (SP), a neuropeptide produced in abundance by skin nerve terminals. SP is without effect on the growth of Gram-positive (Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis) and Gram-negative (Pseudomonas fluorescens) bacteria...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28181518/using-graphene-networks-to-build-bioinspired-self-monitoring-ceramics
#10
Olivier T Picot, Victoria G Rocha, Claudio Ferraro, Na Ni, Eleonora D'Elia, Sylvain Meille, Jerome Chevalier, Theo Saunders, Ton Peijs, Mike J Reece, Eduardo Saiz
The properties of graphene open new opportunities for the fabrication of composites exhibiting unique structural and functional capabilities. However, to achieve this goal we should build materials with carefully designed architectures. Here, we describe the fabrication of ceramic-graphene composites by combining graphene foams with pre-ceramic polymers and spark plasma sintering. The result is a material containing an interconnected, microscopic network of very thin (20-30 nm), electrically conductive, carbon interfaces...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28165139/carboxylated-nanodiamonds-can-be-used-as-negative-reference-in-in-vitro-nanogenotoxicity-studies
#11
H Moche, V Paget, D Chevalier, E Lorge, N Claude, H A Girard, J C Arnault, S Chevillard, F Nesslany
Nanodiamonds (NDs) are promising nanomaterials for biomedical applications. However, a few studies highlighted an in vitro genotoxic activity for detonation NDs, which was not evidenced in one of our previous work quantifying γ-H2Ax after 20 and 100 nm high-pressure high-temperature ND exposures of several cell lines. To confirm these results, in the present work, we investigated the genotoxicity of the same 20 and 100 nm NDs and added intermediate-sized NDs of 50 nm. Conventional in vitro genotoxicity tests were used, i...
February 6, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28160717/a-new-approach-to-characterize-very-low-level-radioactive-waste-produced-at-hadron-accelerators
#12
Biagio Zaffora, Matteo Magistris, Jean-Pierre Chevalier, Catherine Luccioni, Gilbert Saporta, Luisa Ulrici
Radioactive waste is produced as a consequence of preventive and corrective maintenance during the operation of high-energy particle accelerators or associated dismantling campaigns. Their radiological characterization must be performed to ensure an appropriate disposal in the disposal facilities. The radiological characterization of waste includes the establishment of the list of produced radionuclides, called "radionuclide inventory", and the estimation of their activity. The present paper describes the process adopted at CERN to characterize very-low-level radioactive waste with a focus on activated metals...
January 26, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28154576/regulatory-shifts-in-plastid-transcription-play-a-key-role-in-morphological-conversions-of-plastids-during-plant-development
#13
REVIEW
Monique Liebers, Björn Grübler, Fabien Chevalier, Silva Lerbs-Mache, Livia Merendino, Robert Blanvillain, Thomas Pfannschmidt
Plastids display a high morphological and functional diversity. Starting from an undifferentiated small proplastid, these plant cell organelles can develop into four major forms: etioplasts in the dark, chloroplasts in green tissues, chromoplasts in colored flowers and fruits and amyloplasts in roots. The various forms are interconvertible into each other depending on tissue context and respective environmental condition. Research of the last two decades uncovered that each plastid type contains its own specific proteome that can be highly different from that of the other types...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28152543/asporin-is-a-stromally-expressed-marker-associated-with-prostate-cancer-progression
#14
Annie Rochette, Nadia Boufaied, Eleonora Scarlata, Lucie Hamel, Fadi Brimo, Hayley C Whitaker, Antonio Ramos-Montoya, David E Neal, Alice Dragomir, Armen Aprikian, Simone Chevalier, Axel A Thomson
BACKGROUND: Prostate cancer shows considerable heterogeneity in disease progression and we propose that markers expressed in tumour stroma may be reliable predictors of aggressive tumour subtypes. METHODS: We have used Kaplan-Meier, univariate and multivariate analysis to correlate the expression of Asporin (ASPN) mRNA and protein with prostate cancer progression in independent cohorts. We used immunohistochemistry and H scoring to document stromal localisation of ASPN in a tissue microarray and mouse prostate cancer model, and correlated expression with reactive stroma, defined using Masson Trichrome staining...
February 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28139266/-characteristics-diseases-and-mortality-of-people-admitted-to-nursing-homes-for-dependent-seniors-during-the-first-quarter-of-2013%C3%A2-in-france
#15
A Atramont, A Rigault, S Chevalier, G Leblanc, A Fagot-Campagna, P Tuppin
BACKGROUND: To describe the state of health, through healthcare consumption and mortality, of people admitted to nursing homes (Ehpad) in France. METHODS: People over the age of 65 years admitted to an Ehpad institution during the first quarter of 2013, beneficiaries of the national health insurance general scheme (69% of the population of this age), were identified from the Resid-Ehpad database and their reimbursed health care was extracted from the SNIIRAM database, identifying 56 disease groups by means of algorithms (long-term disease diagnoses and hospitalisations, medicinal products, specific procedures)...
January 27, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28137741/pd-l1-protein-expression-assessed-by-immunohistochemistry-is-neither-prognostic-nor-predictive-of-benefit-from-adjuvant-chemotherapy-in-resected-non-small-cell-lung-cancer
#16
M-S Tsao, G Le Teuff, F A Shepherd, C Landais, P Hainaut, M Filipits, R Pirker, T Le Chevalier, S Graziano, R Kratze, J-C Soria, J-P Pignon, L Seymour, E Brambilla
BACKGROUND: The expression of programmed death (PD) ligand 1 (PD-L1) protein expression assessed by immunohistochemistry (IHC) has been correlated with response and survival benefit from anti-PD-1/PD-L1 immune checkpoint inhibitor therapies in advanced non-small cell lung carcinoma (NSCLC). The efficacy of several agents appears correlated with PD-L1 expression. It remains controversial whether PD-L1 is prognostic in NSCLC. We assessed the prognostic value of PD-L1 IHC and its predictive role for adjuvant chemotherapy in early stage NSCLC...
January 30, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28133662/a-luminescent-pt2fe-spin-crossover-complex
#17
Bernhard Schäfer, Thomas Bauer, Isabelle Faus, Juliusz A Wolny, Fabian Dahms, Olaf Fuhr, Sergei Lebedkin, Hans-Christian Wille, Kai Schlage, Katharina Chevalier, Fabian Rupp, Rolf Diller, Volker Schünemann, Manfred M Kappes, Mario Ruben
A heterotrinuclear [Pt2Fe] spin crossover (SCO) complex was developed and synthesized employing a ditopic bridging bpp-alkynyl ligand L and alkynyl coordinated Pt(II) terpy units: [Fe(II)(L-Pt(II))2]2(BF4)2 (1). We identified two different types of crystals of 1 which differ in their molecular packing and the number of co-crystallized solvent molecules: 1H (1·3.5CH2Cl2 in P1[combining macron]) and 1L (1·10CH2Cl2 in C2/c); while 1L shows a reversible SCO with a transition temperature of 268 K, the analogous compound 1H does not show any SCO and remains blocked in the HS state...
January 30, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28128473/obesity-and-radiological-severity-are-associated-with-viscosupplementation-failure-in-patients-with-knee-osteoarthritis
#18
Florent Eymard, Xavier Chevalier, Thierry Conrozier
Viscosupplementation (VS) is still controversial. One of the key points is the lack of well-identified factors of response. We aimed to identify clinical and radiological factors associated with lack of relevant response after intra-articular (IA) hyaluronic acid (HA) injections in symptomatic knee osteoarthritis patients. A post hoc analysis of the HAV-2012 trial, a controlled, multicentre, double-blind, randomized, non-inferiority trial comparing 3 weekly IA injections of HA (HAnox-M or BioHA) for symptomatic tibiofemoral OA was performed...
January 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28123189/health-care-professionals-opinions-and-expectations-of-clinical-pharmacy-services-on-a-surgical-ward
#19
Bernadette Chevalier, Heather L Neville, Kara Thompson, Lisa Nodwell, Michael MacNeil
BACKGROUND: Pharmacists have made significant contributions to patient care and have been recognized as integral members of the interprofessional team. Health care professionals differ in their opinions and expectations of clinical pharmacy services. Very little has been published about health care professionals' perspectives on advanced clinical pharmacy roles, such as prescriptive authority or administration of vaccines. In 2013, clinical pharmacy services were introduced in a vascular and general surgery ward where a pharmacist had not previously been assigned...
November 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28117457/the-aliphatic-amidase-amie-is-involved-in-regulation-of-pseudomonas-aeruginosa-virulence
#20
Thomas Clamens, Thibaut Rosay, Alexandre Crépin, Teddy Grandjean, Takfarinas Kentache, Julie Hardouin, Perrine Bortolotti, Anke Neidig, Marlies Mooij, Mélanie Hillion, Julien Vieillard, Pascal Cosette, Joerg Overhage, Fergal O'Gara, Emeline Bouffartigues, Alain Dufour, Sylvie Chevalier, Benoit Guery, Pierre Cornelis, Marc G J Feuilloley, Olivier Lesouhaitier
We have previously shown that the eukaryotic C-type natriuretic peptide hormone (CNP) regulates Pseudomonas aeruginosa virulence and biofilm formation after binding on the AmiC sensor, triggering the amiE transcription. Herein, the involvement of the aliphatic amidase AmiE in P. aeruginosa virulence regulation has been investigated. The proteome analysis of an AmiE over-producing strain (AmiE(+)) revealed an expression change for 138 proteins, including some that are involved in motility, synthesis of quorum sensing compounds and virulence regulation...
January 24, 2017: Scientific Reports
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