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https://www.readbyqxmd.com/read/28429171/sleeve-gastrectomy-alters-intestinal-permeability-in-diet-induced-obese-mice
#1
Claire Blanchard, François Moreau, Julien Chevalier, Audrey Ayer, Damien Garcon, Lucie Arnaud, Jean-Paul Pais de Barros, Thomas Gautier, Michel Neunlist, Bertrand Cariou, Cédric Le May
BACKGROUND: Increased lipopolysaccharide (LPS) translocation due to altered intestinal permeability has been suggested as a mechanism for obesity-associated insulin resistance. The goal of this study was to assess the effect of sleeve gastrectomy (SG) on intestinal barrier permeability in diet-induced obese mice. MATERIALS AND METHODS: Four weeks after surgery, the effects of SG on intestinal permeabilities were assessed ex vivo and in vivo in male C57Bl/6J mice fed a high-fat diet...
April 20, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28428268/salvage-use-of-allogeneic-hsct-after-reduced-intensity-conditioning-from-unrelated-donors-in-multiple-myeloma-a-study-by-the-plasma-cell-disorders-subcommittee-of-the-ebmt-chronic-malignancies-working-party
#2
Mohamad Sobh, Mauricette Michallet, Valerie Dubois, Simona Iacobelli, Linda Koster, Anja Van Biezen, Nathalie Fegueux, Reza Tabrizi, Jürgen Finke, Jean El-Cheikh, Martin Schipperus, Ellen Meijer, Peter von dem Borne, Eefke Petersen, Nigel Russell, Eleni Tholouli, Jakob Passweg, Frédé Ric Garban, Johan Maertens, Patrice Chevalier, Natacha Maillard, Liisa Volin, Sylvie Francois, Bruno Lioure, Yves Beguin, Eliane Gluckman, Annalisa Ruggeri, Laurent Garderet, Nicolaus Kröger
No abstract text is available yet for this article.
April 20, 2017: Haematologica
https://www.readbyqxmd.com/read/28427903/atrial-fibrillation-is-associated-with-hypermethylation-in-human-left-atrium-and-treatment-with-decitabine-reduces-atrial-tachyarrhythmias-in-spontaneously-hypertensive-rats
#3
R Doñate Puertas, E Meugnier, C Romestaing, C Rey, E Morel, J Lachuer, N Gadot, A Scridon, C Julien, F Tronc, B Chapuis, C Valla, A Janin, L Pirola, A Méjat, S Rome, P Chevalier
Atrial fibrillation (AF) is the most common cardiac arrhythmia. As the molecular mechanisms underlying the pathology are largely unknown, this cardiac arrhythmia remains difficult to treat. To identify specific molecular actors involved in AF, we have performed a transcriptomic analysis on left atrium (LA) from patients with valvular heart disease with or without AF. We showed that 1627 genes had altered basal expression level in LA tissue of AF patients compared with the control group. The significantly enriched gene ontology biological process "anatomical structure morphogenesis" contained the highest number of genes in line with changes in structure that occur when the human heart remodels following AF development (ie, LA dilatation and interstitial fibrosis)...
March 30, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28419117/indirect-effect-of-temperature-on-fish-population-abundances-through-phenological-changes
#4
Lucie Kuczynski, Mathieu Chevalier, Pascal Laffaille, Marion Legrand, Gaël Grenouillet
In response to climate change, earlier phenological events have been reported for a large range of taxa such that phenological shifts are considered as one of the fingerprints of the effect of climate change on organisms. Evidence further suggests that changes in the timing of phenological events might decouple biotic interactions due to differential phenological adjustment among interacting species, ultimately leading to population declines. Nonetheless, few studies have investigated how climate-driven changes in the timing of phenological events influence population abundances...
2017: PloS One
https://www.readbyqxmd.com/read/28419099/getting-ready-to-use-control-advances-in-the-measurement-of-young-children-s-use-of-proactive-control
#5
Sabine Doebel, Jane E Barker, Nicolas Chevalier, Laura E Michaelson, Anna V Fisher, Yuko Munakata
A key developmental transition in executive function is in the temporal dynamics of its engagement: children shift from reactively calling to mind task-relevant information as needed, to being able to proactively maintain information across time in anticipation of upcoming demands. This transition is important for understanding individual differences and developmental changes in executive function; however, methods targeting its assessment are limited. We tested the possibility that Track-It, a paradigm developed to measure selective sustained attention, also indexes proactive control...
2017: PloS One
https://www.readbyqxmd.com/read/28407281/multiparametric-quantitative-ultrasound-imaging-in-assessment-of-chronic-kidney-disease
#6
Jing Gao, Alan Perlman, Safa Kalache, Nathaniel Berman, Surya Seshan, Steven Salvatore, Lindsey Smith, Natasha Wehrli, Levi Waldron, Hanish Kodali, James Chevalier
OBJECTIVES: To evaluate the value of multiparametric quantitative ultrasound imaging in assessing chronic kidney disease (CKD) using kidney biopsy pathologic findings as reference standards. METHODS: We prospectively measured multiparametric quantitative ultrasound markers with grayscale, spectral Doppler, and acoustic radiation force impulse imaging in 25 patients with CKD before kidney biopsy and 10 healthy volunteers. Based on all pathologic (glomerulosclerosis, interstitial fibrosis/tubular atrophy, arteriosclerosis, and edema) scores, the patients with CKD were classified into mild (no grade 3 and <2 of grade 2) and moderate to severe (at least 2 of grade 2 or 1 of grade 3) CKD groups...
April 13, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28400425/the-logic-of-transcriptional-regulator-recruitment-architecture-at-cis-regulatory-modules-controlling-liver-functions
#7
Julie Dubois-Chevalier, Vanessa Dubois, Hélène Dehondt, Parisa Mazrooei, Claire Mazuy, Aurélien A Sérandour, Céline Gheeraert, Guillaume Penderia, Eric Baugé, Bruno Derudas, Nathalie Hennuyer, Réjane Paumelle, Guillemette Marot, Jason S Carroll, Mathieu Lupien, Bart Staels, Philippe Lefebvre, Jérôme Eeckhoute
Control of gene transcription relies on concomitant regulation by multiple transcriptional regulators (TR). However, how recruitment of a myriad of TR is orchestrated at cis-regulatory modules (CRM) to account for co-regulation of specific biological pathways is only partially understood. Here, we have used mouse liver CRM involved in regulatory activities of the hepatic TR, NR1H4 (FXR; farnesoid X receptor), as our model system to tackle this question. Using integrative cistromic, epigenomic, transcriptomic and interactomic analyses, we reveal a logical organization where trans-regulatory modules (TRM), which consist of subsets of preferentially and co-ordinately co-recruited TR, assemble into hierarchical combinations at hepatic CRM...
April 11, 2017: Genome Research
https://www.readbyqxmd.com/read/28397991/willing-to-think-hard-the-subjective-value-of-cognitive-effort-in-children
#8
Nicolas Chevalier
Cognitive effort is costly and this cost likely influences the activities in which children engage. Yet, little is known about how school-age children perceive cognitive effort. The subjective value of cognitive effort, that is, how valuable or costly effort is perceived, was investigated in seventy-three 7- to 12-year-olds using an effort discounting paradigm. In two studies, it varied with task difficulty but not age, was predicted by actual effort engagement but not actual success and related to trait interest in effortful activities and proactive control engagement...
April 11, 2017: Child Development
https://www.readbyqxmd.com/read/28392417/pharmacological-inhibition-of-carnitine-palmitoyltransferase-1-restores-mitochondrial-oxidative-phosphorylation-in-human-trifunctional-protein-deficient-fibroblasts
#9
Bruno Lefort, Elodie Gouache, Cécile Acquaviva, Marine Tardieu, Jean François Benoist, Jean-François Dumas, Stéphane Servais, Stéphan Chevalier, Christine Vianey-Saban, François Labartheh
BACKGROUND: Mitochondrial Trifunctional Protein deficiency (TFPD) is a severe genetic disease characterized by altered energy metabolism and accumulation of long-chain (LC) acylcarnitines in blood and tissues. This accumulation could impair the mitochondrial oxidative phosphorylation (OxPhos), contributing to the non-optimal outcome despite conventional diet therapy with medium-chain triglycerides (MCT). METHOD: Acylcarnitine and OxPhos parameters were measured in TFPD-fibroblasts obtained from 8 children and cultured in medium mimicking fasting (LCFA) or conventional treatment (MCT), with or without Etomoxir (ETX) an inhibitor of carnitine palmitoyltransferase 1 (CPT1) activity, and were compared to results obtained with fibroblasts from 5 healthy-control children...
April 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28390735/laboratory-based-x-ray-photoemission-core-level-spectromicroscopy-of-resistive-oxide-memories
#10
Daniel M Gottlob, Eugénie Martinez, Claire Mathieu, Christophe Lubin, Nicolas Chevalier, Munique Kazar Mendes, Christelle Charpin, Eric Jalaguier, Olivier Renault, Nicholas Barrett
HfO2-based resistive oxide memories are studied by core-level spectromicroscopy using a laboratory-based X-ray photoelectron emission microscope (XPEEM). After forming, the top electrode is thinned to about 1 nm for the XPEEM analysis, making the buried electrode/HfO2 interface accessible whilst preserving it from contamination. The results are obtained in the true photoemission channel mode from individual memory cells (5 × 5 µm) excited by low-flux laboratory X-rays, in contrast to most studies employing the X-ray absorption channel using potentially harmful bright synchrotron X-rays...
March 23, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28382915/risk-factors-for-mers-coronavirus-infection-in-dromedary-camels-in-burkina-faso-ethiopia-and-morocco-2015
#11
Eve Miguel, Véronique Chevalier, Gelagay Ayelet, Med Nadir Ben Bencheikh, Hiver Boussini, Daniel Kw Chu, Ikhlass El Berbri, Ouaffa Fassi-Fihri, Bernard Faye, Getnet Fekadu, Vladimir Grosbois, Bryan Cy Ng, Ranawaka Apm Perera, T Y So, Amadou Traore, François Roger, Malik Peiris
Understanding Middle East respiratory syndrome coronavirus (MERS-CoV) transmission in dromedary camels is important, as they consitute a source of zoonotic infection to humans. To identify risk factors for MERS-CoV infection in camels bred in diverse conditions in Burkina Faso, Ethiopia and Morocco, blood samples and nasal swabs were sampled in February-March 2015. A relatively high MERS-CoV RNA rate was detected in Ethiopia (up to 15.7%; 95% confidence interval (CI): 8.2-28.0), followed by Burkina Faso (up to 12...
March 30, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28379077/perils-of-using-speed-zone-data-to-assess-real-world-compliance-to-speed-limits
#12
Anna Chevalier, Elizabeth Clarke, Aran John Chevalier, Julie Brown, Kristy Coxon, Rebecca Ivers, Lisa Keay
OBJECTIVE: Real world driving studies, including those involving speeding alert devices and autonomous vehicles, can gauge an individual vehicle's speeding behaviour by comparing measured speed with mapped speed zone data. However, there are complexities with developing and maintaining a database of mapped speed zones over a large geographic area that may lead to inaccuracies within the dataset. When this approach is applied to large-scale real world driving data or speeding alert device data to determine speeding behaviour, these inaccuracies may result in invalid identification of speeding...
April 5, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28372279/circulating-endothelial-progenitors-in-vascular-repair
#13
S Ferratge, J Boyer, N Arouch, F Chevalier, G Uzan
Endothelial Colony Forming Cells (ECFCs) are obtained in culture from Circulating Endothelial Progenitor Cells. They display all characteristics of endothelial cells and they display stem cells features. Cord blood-derived ECFCs (CB-ECFCs) have a high clonogenic and proliferative potentials, and exhibit vascular repair capabilities useful for the treatment of ischemic diseases. However, the link between immaturity and functional properties of CB-ECFCs is still poorly defined. We showed that these cells have a high clonogenic potential and are capable to be efficiently reprogrammed into induced pluripotent stem cells...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28370932/investigating-strategies-used-by-hospital-pharmacists-to-effectively-communicate-with-patients-during-medication-counselling
#14
Bernadette A M Chevalier, Bernadette M Watson, Michael A Barras, William Neil Cottrell
BACKGROUND: Medication counselling opportunities are key times for pharmacists and patients to discuss medications and patients' concerns about their therapy. Communication Accommodation Theory (CAT) describes behavioural, motivational and emotional processes underlying communication exchanges. Five CAT strategies (approximation, interpretability, discourse management, emotional expression and interpersonal control) permit identification of effective communication. OBJECTIVE: To invoke CAT to investigate communication strategies used by hospital pharmacists during patient medication counselling...
March 30, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28369944/increasing-acetyl-coa-metabolism-attenuates-injury-and-alters-spinal-cord-lipid-content-in-mice-subjected-to-experimental-autoimmune-encephalomyelitis
#15
Amber C Chevalier, Thad A Rosenberger
Acetate supplementation increases brain acetyl-CoA metabolism, alters histone and non-histone protein acetylation, increases brain energy reserves, and is anti-inflammatory and neuroprotective in rat models of neuroinflammation and neuroborreliosis. To determine the impact acetate supplementation has on a mouse model of multiple sclerosis, we quantified the effect treatment had on injury progression, spinal cord lipid content, phospholipase levels, and myelin structure in mice subjected to experimental autoimmune encephalomyelitis (EAE)...
March 31, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28369617/cell-layer-specific-patterns-of-cell-division-and-cell-expansion-during-fruit-set-and-fruit-growth-in-tomato-pericarp
#16
Jean-Pierre Renaudin, Cynthia Deluche, Catherine Cheniclet, Christian Chevalier, Nathalie Frangne
In angiosperms, the ovary wall resumes growth after pollination through a balanced combination of cell division and cell expansion. The quantitative pattern of these events remains poorly known in fleshy fruits such as tomato (Solanum spp.), in which dramatic growth of the pericarp occurs together with endoreduplication. Here, this pattern is reported at the level of each of the cell layers or groups of cell layers composing the pericarp, except for vascular bundles. Overall, cell division and cell expansion occurred at similar rates for 9 days post anthesis (DPA), with very specific patterns according to the layers...
March 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28360020/strain-rate-influence-on-human-cortical-bone-toughness-a-comparative-study-of-four-paired-anatomical-sites
#17
Rémy Gauthier, Hélène Follet, Max Langer, Sylvain Meille, Jérôme Chevalier, Frédéric Rongiéras, Françoise Peyrin, David Mitton
Bone fracture is a major health issue worldwide and consequently there have been extensive investigations into the fracture behavior of human cortical bone. However, the fracture properties of human cortical bone under fall-like loading conditions remains poorly documented. Further, most published research has been performed on femoral diaphyseal bone, whereas it is known that the femoral neck and the radius are the most vulnerable sites to fracture. Hence, the aim of this study is to provide information on human cortical bone fracture behavior by comparing different anatomical sites including the radius and the femoral neck acquired from 32 elderly subjects (50 - 98 y...
March 22, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28358573/investigating-the-longitudinal-effects-of-surface-acting-on-managers-functioning-through-psychological-needs
#18
Tiphaine Huyghebaert, Nicolas Gillet, Claude Fernet, Fadi-Joseph Lahiani, Séverine Chevalier, Evelyne Fouquereau
This study is based on the premise that managers are expected to regulate their emotions in the form of surface acting. More specifically, drawing on self-determination theory, we explored the role of psychological needs for autonomy, competence, and relatedness in explaining the influence of surface acting on supervisors' job satisfaction and work engagement over time. Data were collected at 2 time points, over a 3-month period, from a sample of 435 French managers working in the health care industry. Results revealed that surface acting negatively predicted managers' job satisfaction and work engagement over time, through the satisfaction of their psychological needs...
March 30, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28350829/spatio-temporal-variation-of-fish-taxonomic-composition-in-a-south-east-asian-flood-pulse-system
#19
Heng Kong, Mathieu Chevalier, Pascal Laffaille, Sovan Lek
The Tonle Sap Lake (TSL) is a flood-pulse system. It is the largest natural lake in South-East Asia and constitutes one of the largest fisheries over the world, supporting the livelihood of million peoples. Nonetheless, the Mekong River Basin is changing rapidly due to accelerating water infrastructure development (hydropower, irrigation, flood control, and water supply) and climate change, bringing considerable modifications to the annual flood-pulse of the TSL. Such modifications are expected to have strong impacts on fish biodiversity and abundance...
2017: PloS One
https://www.readbyqxmd.com/read/28346869/multisensory-object-perception-in-infancy-4-month-olds-perceive-a-mistuned-harmonic-as-a-separate-auditory-and-visual-object
#20
Nicholas A Smith, Nicole A Folland, Diana M Martinez, Laurel J Trainor
Infants learn to use auditory and visual information to organize the sensory world into identifiable objects with particular locations. Here we use a behavioural method to examine infants' use of harmonicity cues to auditory object perception in a multisensory context. Sounds emitted by different objects sum in the air and the auditory system must figure out which parts of the complex waveform belong to different sources (auditory objects). One important cue to this source separation is that complex tones with pitch typically contain a fundamental frequency and harmonics at integer multiples of the fundamental...
March 24, 2017: Cognition
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