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https://www.readbyqxmd.com/read/29169170/mite-induced-asthma-and-ige-levels-to-shrimp-mite-tropomyosin-arginine-kinase-and-der-p-10-are-the-most-relevant-risk-factors-for-challenge-proven-shrimp-allergy
#1
Laura Farioli, Laura Michelina Losappio, Maria Gabriella Giuffrida, Valerio Pravettoni, Gianluigi Micarelli, Michele Nichelatti, Joseph Scibilia, Corrado Mirone, Laura Cavallarin, Cristina Lamberti, Luca Giuseppe Balossi, Elide Anna Pastorello
BACKGROUND: Shrimp sensitization is common in the general population, but the presence of symptoms is only moderately related to sensitization. A point still at issue is which in vivo and/or in vitro tests (food challenge, component-resolved diagnosis, house dust mite [HDM] sensitization) can help in distinguishing shrimp-allergic subjects from subjects that are sensitized but tolerant. METHODS: The aim of this study was to evaluate the role of IgE to the different shrimp and mite allergens in distinguishing shrimp challenge-positive from challenge-negative patients...
November 24, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29169144/targeting-the-wnt-beta-catenin-pathway-in-cancer-update-on-effectors-and-inhibitors
#2
REVIEW
Nithya Krishnamurthy, Razelle Kurzrock
The Wnt/beta-catenin pathway is a family of proteins that is implicated in many vital cellular functions like stem cell regeneration and organogenesis. Several intra-cellular signal transduction pathways are induced by Wnt, notably the Wnt/beta-catenin dependent pathway or canonical pathway and the non-canonical or beta-catenin-independent pathway, the latter includes the Wnt/Ca2+ and Planar Cell Polarity pathway (PCP). Wnt activation occurs at the intestinal crypt floor, and is critical to optimal maintenance of stem cells...
November 13, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29169104/reconciling-ethical-and-economic-conceptions-of-value-in-health-policy-using-the-capabilities-approach-a-qualitative-investigation-of-non-invasive-prenatal-testing
#3
Mia Kibel, Meredith Vanstone
When evaluating new morally complex health technologies, policy decision-makers consider a broad range of different evaluations, which may include the technology's clinical effectiveness, cost effectiveness, and social or ethical implications. This type of holistic assessment is challenging, because each of these evaluations may be grounded in different and potentially contradictory assumptions about the technology's value. One such technology where evaluations conflict is Non-Invasive Prenatal Testing (NIPT)...
November 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29168946/using-an-electronic-assessment-system-for-nursing-students-on-placements
#4
Julie Smith, Walter Cambers
Electronic assessment is gaining popularity in clinically based elements of pre-registration nurse education. In this study, the authors explored student nurse and mentor experiences during transition from a paper to an electronic system. Mixed research methods used included survey questionnaires and focus groups. Student nurses and their mentors (both n=5) discussed and rated their confidence and skills in information technology and their experience of an electronic assessment document before and after two successive clinical placements...
November 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29168739/early-or-late-feeding-after-icu-admission
#5
REVIEW
Annika Reintam Blaser, Mette M Berger
The feeding of critically ill patients has recently become a controversial issue, as several studies have provided unexpected and contradictory results. Earlier beliefs regarding energy requirements in critical illness-especially during the initial phase-have been challenged. In the current review, we summarize existing evidence about fasting and the impact of early vs. late feeding on the sick organism's responses. The most important points are the non-nutritional advantages of using the intestine, and recognition that early endogenous energy production as an important player in the response must be integrated in the nutrient prescription...
November 23, 2017: Nutrients
https://www.readbyqxmd.com/read/29168679/what-should-leaders-do-when-inefficiency-is-perceived-as-a-cost-of-inclusivity-in-strategic-planning-processes-in-health-care
#6
Aveena Kochar, Alia Chisty
During the development of new health care policies, quality improvement teams can face the challenge of weighing differing opinions within the group that can hinder progress. It is essential in such cases to refer to the four keys principles of quality improvement (QI) as a guide to enhance group cooperation and promote development of the mutual objective. Co-production is a model that emphasizes the participation of the patient-a service receiver-in the production of services being rendered by the health care professional...
November 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/29168669/awake-craniotomy-versus-craniotomy-under-general-anesthesia-for-the-surgical-treatment-of-insular-glioma-choices-and-outcomes
#7
B Y Gravesteijn, M E Keizer, A J P E Vincent, J W Schouten, R J Stolker, M Klimek
OBJECTIVE: To investigate differences in outcomes in patients who underwent surgery for insular glioma using an awake craniotomy (AC) vs. a craniotomy under general anesthesia (GA). METHODS: Data from patients treated at our hospital between 2005 and 2015 were analyzed retrospectively. The preoperative, intraoperative, postoperative, and longer term follow-up characteristics and outcomes of patients who underwent surgery for primary insular glioma using either an AC or GA were compared...
November 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29168667/arterial-spin-labeling-for-the-measurement-of-cerebral-perfusion-and-angiography
#8
Peter Jezzard, Michael A Chappell, Thomas W Okell
Arterial spin labeling (ASL) is an MRI technique that was first proposed a quarter of a century ago. It offers the prospect of non-invasive quantitative measurement of cerebral perfusion, making it potentially very useful for research and clinical studies, particularly where multiple longitudinal measurements are required. However, it has suffered from a number of challenges, including a relatively low signal-to-noise ratio, and a confusing number of sequence variants, thus hindering its clinical uptake. Recently, however, there has been a consensus adoption of an accepted acquisition and analysis framework for ASL, and thus a better penetration onto clinical MRI scanners...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29168466/new-delhi-metallo-%C3%AE-lactamase-type-carbapenemases-producing-escherichia-coli-isolates-from-hospitalized-patients-a-pilot-study
#9
Shyam Sunder Grover, Ananya Doda, Nupur Gupta, Inderjeet Gandhoke, Jyoti Batra, Charoo Hans, Shashi Khare
BACKGROUND & OBJECTIVES: Resistances to carbapenem group of antimicrobials among Escherichia coli due to production of carbapenemases, especially the New Delhi metallo-β-lactamase (NDM) types, pose serious challenges in the treatment of infections in healthcare settings. This study was undertaken to detect NDM producing E. coli isolates from hospitalized patients with urinary tract infection (UTI). METHODS: A total of 30 non-repetitive isolates of E. coli from hospitalized patients with clinical suspicion of UTI were subjected to antimicrobial susceptibility testing...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29168434/changes-in-knee-shape-and-geometry-resulting-from-total-knee-arthroplasty
#10
Mohsen Akbari Shandiz, Paul Boulos, Stefan Karl Saevarsson, Heiko Ramm, Chun Kit Jack Fu, Stephen Miller, Stefan Zachow, Carolyn Anglin
Changes in knee shape and geometry resulting from total knee arthroplasty can affect patients in numerous important ways: pain, function, stability, range of motion, and kinematics. Quantitative data concerning these changes have not been previously available, to our knowledge, yet are essential to understand individual experiences of total knee arthroplasty and thereby improve outcomes for all patients. The limiting factor has been the challenge of accurately measuring these changes. Our study objective was to develop a conceptual framework and analysis method to investigate changes in knee shape and geometry, and prospectively apply it to a sample total knee arthroplasty population...
November 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29168232/current-state-and-future-of-paediatric-allergology-in-europe-a-road-map
#11
Olympia Tsilochristou, Paraskevi Maggina, Zaraquiza Zolkipli, Silvia Sanchez Garcia, Pinar Uysal, Monserrat Alvaro Lozano, Marina Atanaskovic-Markovic, Astghik Baghdasaryan, Kirsten Beyer, George DuToit, Roy Gerth van Wijk, Arne Høst, Jonathan O'Hourihane, Lars Ingemann, Juho E Kivistö, Jose Manuel Lopes Dos Santos, Erik Melén, Muraro Antonella, Antonio Nieto, Giovanni Pajno, Klaus Rose, Lagos A Réthy, Cansin Sackesen, Peter Schmid Grendelmeier, Erkka Valovirta, Magnus Wickman, Philippe A Eigenmann, Ulrich Wahn, Lauri-Ann van der Poel
The history of pediatric allergology (PA) in Europe is relatively youthful, dating back to 1984, when a small group of pediatricians founded the European Working Group on Pediatric Allergy and Immunology - later giving rise to ESPACI (European Society on Pediatric Allergology and Clinical Immunology). In 1990, the first dedicated journal, Pediatric Allergy and Immunology (PAI), was founded. There are striking differences across Europe, and even within European countries, in relation to the training pathways for doctors seeing children with allergic disease(s)...
November 23, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29168190/innovative-food-products-for-cancer-patients-future-directions
#12
Itziar Tueros, Matxalen Uriarte
One of the main challenges for cancer patients under treatment is to prevent and tackle malnutrition. The current clinical nutrition market offers different food supplements or oral nutritional support products (mainly milkshakes or modified texture products) for cancer patients under risk of malnutrition. However, it is worth mentioning, that these products do not address the pleasure of eating, since they do not meet sensory requirements, such as taste and smell alterations, nor patients' food preferences, leading to a big impact on their quality of life (QOL)...
November 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29168077/progress-and-challenges-of-sequencing-and-analyzing-circulating-tumor-cells
#13
REVIEW
Zhongyi Zhu, Si Qiu, Kang Shao, Yong Hou
Circulating tumor cells (CTCs) slough off primary tumor tissues and are swept away by the circulatory system. These CTCs can remain in circulation or colonize new sites, forming metastatic clones in distant organs. Recently, CTC analyses have been successfully used as effective clinical tools to monitor tumor progression and prognosis. With advances in next-generation sequencing (NGS) and single-cell sequencing (SCS) technologies, scientists can obtain the complete genome of a CTC and compare it with corresponding primary and metastatic tumors...
November 22, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/29168073/fungus-specific-cd4-t-cells-as-specific-sensors-for-identification-of-pulmonary-fungal-infections
#14
Alexander Scheffold, Carsten Schwarz, Petra Bacher
Patients with cystic fibrosis (CF) suffer from chronic lung infections, caused by bacterial, viral or fungal pathogens, which determine morbidity and mortality. The contribution of individual pathogens to chronic disease and acute lung exacerbations is often difficult to determine due to the complex composition of the lung microbiome in CF. In particular, the relevance of fungal pathogens in CF airways remains poorly understood due to limitations of current diagnostics to identify the presence of fungal pathogens and to resolve the individual host-pathogen interaction status...
November 22, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29167954/no-implant-migration-and-good-subjective-outcome-of-a-novel-customized-femoral-resurfacing-metal-implant-for-focal-chondral-lesions
#15
Anders Stålman, Olof Sköldenberg, Nicolas Martinez-Carranza, David Roberts, Magnus Högström, Leif Ryd
PURPOSE: Managing focal cartilage injuries in the middle-aged patient poses a challenge. Focal prosthetic inlay resurfacing has been proposed to be a bridge between biologics and conventional joint arthroplasty. Patient selection and accurate implant positioning is crucial to avoid increased contact pressure to the opposite cartilage surface. A customized femoral condyle implant for focal cartilage injuries was designed to precisely fit each patient's individual size and location of damage...
November 22, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29167908/a-pilot-single-centre-cross-sectional-study-to-determine-the-knowledge-and-management-of-sports-concussion-by-emergency-physicians-an-experience-from-singapore
#16
Dinesh Sirisena, Joy Walter, Joo Haw Ong, Joanne Probert
INTRODUCTION: Sports concussion remains a challenging condition to manage despite changes to policy and practice since the 2012 Concussion in Sport Group consensus meeting. Emergency physicians (EPs) are often the first line of medical care for athletes in amateur and youth collision sports. This single-centre cross-sectional study aimed to establish the understanding and management of concussion by EPs in Singapore. METHODS: An anonymised 17-item online questionnaire was sent out to EPs using the Google Forms application, requesting information on clinical experience, training, exposure to concussion cases in the emergency department (ED) and assessed knowledge of the condition...
November 13, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29167818/a-validation-dataset-for-macaque-brain-mri-segmentation
#17
Yaël Balbastre, Denis Rivière, Nicolas Souedet, Clara Fischer, Anne-Sophie Hérard, Susannah Williams, Michel E Vandenberghe, Julien Flament, Romina Aron-Badin, Philippe Hantraye, Jean-François Mangin, Thierry Delzescaux
Validation data for segmentation algorithms dedicated to preclinical images is fiercely lacking, especially when compared to the large number of databases of Human brain images and segmentations available to the academic community. Not only is such data essential for validating methods, it is also needed for objectively comparing concurrent algorithms and detect promising paths, as segmentation challenges have shown for clinical images. The dataset we present here is a first step in this direction. It comprises 10 T2-weighted MRIs of healthy adult macaque brains, acquired on a 7 T magnet, along with corresponding manual segmentations into 17 brain anatomic labelled regions spread over 5 hierarchical levels based on a previously published macaque atlas (Calabrese et al...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29167805/clinical-potential-of-mesenchymal-stem-stromal-cell-derived-extracellular-vesicles
#18
REVIEW
Bernd Giebel, Lambros Kordelas, Verena Börger
Within the last two decades mesenchymal stem/stromal cells (MSCs) emerged after hematopoietic stem cells as the second most investigated and applied somatic stem cell entity so far. MSCs mediate immunosuppressive as well as pro-regenerative activities. Against the initial assumption, MSCs may not primarily exert their therapeutic functions in a cellular but rather in a paracrine manner. Here, extracellular vesicles (EVs), such as exosomes and microvesicles, have been identified as major mediators of these paracrine effects...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/29167687/effect-of-self-adhesive-and-separate-etch-adhesive-dual-cure-resin-cements-on-the-bond-strength-of-fiber-post-to-dentin-at-different-parts-of-the-root
#19
Ehsan Mohamadian Amiri, Fariba Balouch, Faezeh Atri
Objectives: Bonding of fiber posts to intracanal dentin is challenging in the clinical setting. This study aimed to compare the effect of self-adhesive and separate etch adhesive dual cure resin cements on the bond strength of fiber post to dentin at different parts of the root. Materials and Methods: This in-vitro experimental study was conducted on 20 single-rooted premolars. The teeth were decoronated at 1mm coronal to the cementoenamel junction (CEJ), and the roots underwent root canal treatment...
May 2017: Journal of Dentistry of Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/29167672/novel-concept-of-cd4-mediated-activation-of-regulatory-t-cells-for-the-treatment-of-graft-versus-host-disease
#20
REVIEW
Janine Schlöder, Carsten Berges, Andrea Tuettenberg, Helmut Jonuleit
Allogeneic hematopoietic stem cell transplantation is the only curative treatment option for several hematological malignancies and immune deficiency syndromes. Nevertheless, the development of a graft-versus-host disease (GvHD) after transplantation is a high risk and a severe complication with high morbidity and mortality causing therapeutic challenges. Current pharmacological therapies of GvHD lead to generalized immunosuppression followed by severe adverse side effects including infections and relapse of leukemia...
2017: Frontiers in Immunology
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