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John-Michael Gamble

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https://www.readbyqxmd.com/read/27865756/association-of-insulin-dosage-with-mortality-or-major-adverse-cardiovascular-events-a-retrospective-cohort-study
#1
John-Michael Gamble, Eugene Chibrikov, Laurie K Twells, William K Midodzi, Stephanie W Young, Don MacDonald, Sumit R Majumdar
BACKGROUND: Existing studies have shown conflicting evidence regarding the safety of exogenous insulin therapy in patients with type 2 diabetes. In particular, observational studies have reported an increased risk of death and cardiovascular disease among users of higher versus lower doses of insulin. We aimed to quantify the association between increasing dosage of insulin exposure and death and cardiovascular events, while taking into account time-dependent confounding and mediation that might have biased previous studies...
November 16, 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27737686/effectiveness-of-a-pharmacist-driven-intervention-in-copd-epic-study-protocol-for-a-randomized-controlled-trial
#2
Erin Davis, Carlo Marra, John-Michael Gamble, Jamie Farrell, Joe Lockyer, J Mark FitzGerald, Waseem Abu-Ashour, Charlie Gillis, John Hawboldt
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) are often nonadherent with medications and have poor inhaler technique. Community pharmacists can help to improve health-related quality of life and overall outcomes in patients with COPD. We aim to measure the effectiveness of a systematic, pharmacist-driven intervention on patients with diagnosed COPD. METHODS/DESIGN: This pragmatic, parallel-group, cluster randomized controlled trial is designed to determine the effectiveness of a multifactorial, pharmacist-led intervention on medication adherence, inhaler technique, health-related quality of life, health care resource utilization including COPD exacerbations, and use of medications...
October 13, 2016: Trials
https://www.readbyqxmd.com/read/27589898/the-effect-of-smartphone-interventions-on-patients-with-chronic-obstructive-pulmonary-disease-exacerbations-a-systematic-review-and-meta-analysis
#3
Meshari Alwashmi, John Hawboldt, Erin Davis, Carlo Marra, John-Michael Gamble, Waseem Abu Ashour
BACKGROUND: The prevalence and mortality rates of chronic obstructive pulmonary disease (COPD) are increasing worldwide. Therefore, COPD remains a major public health problem. There is a growing interest in the use of smartphone technology for health promotion and disease management interventions. However, the effectiveness of smartphones in reducing the number of patients having a COPD exacerbation is poorly understood. OBJECTIVE: To summarize and quantify the association between smartphone interventions and COPD exacerbations through a comprehensive systematic review and meta-analysis...
September 1, 2016: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/27528374/safety-and-efficacy-of-incretin-based-therapies-in-patients-with%C3%A2-type-2-diabetes-mellitus-and-ckd-a-systematic-review%C3%A2-and-meta-analysis
#4
Patricia M Howse, Lyudmila N Chibrikova, Laurie K Twells, Brendan J Barrett, John-Michael Gamble
BACKGROUND: The pharmacokinetics and pharmacodynamics of antidiabetic therapies for patients with type 2 diabetes are often altered in the context of chronic kidney disease (CKD). STUDY DESIGN: Systematic review and meta-analysis. SETTING & POPULATION: Patients with type 2 diabetes and CKD. SELECTION CRITERIA FOR STUDIES: 2 reviewers independently screened studies identified through bibliographic databases (Cochrane Library, PubMed, Embase, International Pharmaceutical Abstracts), clinical trial registries, and references from pertinent articles and clinical practice guidelines...
August 12, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27480247/technology-enabled-remote-monitoring-and-self-management-vision-for-patient-empowerment-following-cardiac-and-vascular-surgery-user-testing-and-randomized-controlled-trial-protocol
#5
Michael McGillion, Jennifer Yost, Andrew Turner, Duane Bender, Ted Scott, Sandra Carroll, Paul Ritvo, Elizabeth Peter, Andre Lamy, Gill Furze, Kirsten Krull, Valerie Dunlop, Amber Good, Nazari Dvirnik, Debbie Bedini, Frank Naus, Shirley Pettit, Shaunattonie Henry, Christine Probst, Joseph Mills, Elaine Gossage, Irene Travale, Janine Duquette, Christy Taberner, Sanjeev Bhavnani, James S Khan, David Cowan, Eric Romeril, John Lee, Tracey Colella, Manon Choinière, Jason Busse, Joel Katz, J Charles Victor, Jeffrey Hoch, Wanrudee Isaranuwatchai, Sharon Kaasalainen, Salima Ladak, Sheila O'Keefe-McCarthy, Monica Parry, Daniel I Sessler, Michael Stacey, Bonnie Stevens, Robyn Stremler, Lehana Thabane, Judy Watt-Watson, Richard Whitlock, Joy C MacDermid, Marit Leegaard, Robert McKelvie, Michael Hillmer, Lynn Cooper, Gavin Arthur, Krista Sider, Susan Oliver, Karen Boyajian, Mark Farrow, Chris Lawton, Darryl Gamble, Jake Walsh, Mark Field, Sandra LeFort, Wendy Clyne, Maria Ricupero, Laurie Poole, Karsten Russell-Wood, Michael Weber, Jolene McNeil, Robyn Alpert, Sarah Sharpe, Sue Bhella, David Mohajer, Sem Ponnambalam, Naeem Lakhani, Rabia Khan, Peter Liu, P J Devereaux
BACKGROUND: Tens of thousands of cardiac and vascular surgeries (CaVS) are performed on seniors in Canada and the United Kingdom each year to improve survival, relieve disease symptoms, and improve health-related quality of life (HRQL). However, chronic postsurgical pain (CPSP), undetected or delayed detection of hemodynamic compromise, complications, and related poor functional status are major problems for substantial numbers of patients during the recovery process. To tackle this problem, we aim to refine and test the effectiveness of an eHealth-enabled service delivery intervention, TecHnology-Enabled remote monitoring and Self-MAnagemenT-VIsion for patient EmpoWerment following Cardiac and VasculaR surgery (THE SMArTVIEW, CoVeRed), which combines remote monitoring, education, and self-management training to optimize recovery outcomes and experience of seniors undergoing CaVS in Canada and the United Kingdom...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27450931/steep-delay-discounting-and-addictive-behavior-a-meta-analysis-of-continuous-associations
#6
Michael Amlung, Lana Vedelago, John Acker, Iris Balodis, James MacKillop
AIMS: To synthesize continuous associations between delayed reward discounting (DRD) and both addiction severity and quantity-frequency (QF); to examine moderators of these relationships; and to investigate publication bias. METHODS: Meta-analysis of published studies examining continuous associations between DRD and addictive behaviors. Published, peer-reviewed studies on addictive behaviors (alcohol, tobacco, cannabis, stimulants, opiates and gambling) were identified via PubMed, MEDLINE and PsycInfo...
July 23, 2016: Addiction
https://www.readbyqxmd.com/read/27368005/comparative-effectiveness-of-incretin-based-therapies-and-the-risk-of-death-and-cardiovascular-events-in-38-233-metformin-monotherapy-users
#7
John-Michael Gamble, Jamie M Thomas, Laurie K Twells, William K Midodzi, Sumit R Majumdar
There is limited comparative effectiveness evidence to guide approaches to managing diabetes in individuals failing metformin monotherapy. Our aim was to compare the incidence of all-cause mortality and major adverse cardiovascular events (MACEs) among new metformin monotherapy users initiating a dipeptidyl-peptidase-4 inhibitor (DPP4i), glucagon-like peptide-1 receptor agonist (GLP-1RA), sulfonylurea (SU), thiazolidinedione, or insulin.We conducted a cohort study using the UK-based Clinical Practice Research Datalink...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27177139/highway-deicing-salt-dynamic-runoff-to-surface-water-and-subsequent-infiltration-to-groundwater-during-severe-uk-winters
#8
Michael O Rivett, Mark O Cuthbert, Richard Gamble, Lucy E Connon, Andrew Pearson, Martin G Shepley, John Davis
Dynamic impact to the water environment of deicing salt application at a major highway (motorway) interchange in the UK is quantitatively evaluated for two recent severe UK winters. The contaminant transport pathway studied allowed controls on dynamic highway runoff and storm-sewer discharge to a receiving stream and its subsequent leakage to an underlying sandstone aquifer, including possible contribution to long-term chloride increases in supply wells, to be evaluated. Logged stream electrical-conductivity (EC) to estimate chloride concentrations, stream flow, climate and motorway salt application data were used to assess salt fate...
September 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/26914189/management-of-non-st-elevation-acute-coronary-syndrome-patients-in-new-zealand-a-longitudinal-analysis-results-from-the-new-zealand-acute-coronary-syndrome-national-audits-of-2002-2007-and-2012
#9
MULTICENTER STUDY
Gerry Devlin, Michael Williams, John Elliott, Harvey Douglas White, John French, Greg Gamble, Philip Matsis, Richard Troughton, Mark Richards, Chris Ellis
AIMS: The first New Zealand Acute Coronary Syndrome (ACS) national audit of 2002 was a collaborative effort between clinicians and nurses, and demonstrated important limitations to Non ST-elevation ACS patient (NSTEACS) care. A momentum for change was created. Subsequent audits in 2007 and 2012 allow assessment over time. METHODS: Over 14 days in May 2002, 2007 and 2012, patients with suspected ACS admitted to a hospital in New Zealand were audited. 'Definite' ACS was determined at discharge, after in-hospital investigations; we reviewed NSTEACS patients...
January 8, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/26795395/type-of-gambling-as-an-independent-risk-factor-for-suicidal-events-in-pathological-gamblers
#10
Anja Bischof, Christian Meyer, Gallus Bischof, Ulrich John, Friedrich Martin Wurst, Natasha Thon, Michael Lucht, Hans-Joergen Grabe, Hans-Juergen Rumpf
Individuals with pathological gambling have an increased risk for suicidal events. Additionally, the prevalence of comorbid psychiatric disorders is high among pathological gamblers. This study analyzes whether the type of gambling is associated with suicidal events in pathological gamblers independently from comorbidity. Participants were recruited in 4 different ways: via random telephone sample from the general population, via individual invitation for study participation in gambling locations, through various media and the distribution of a leaflet in various settings, and via inpatient treatment facilities for pathological gambling...
March 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/26191945/suboptimal-foraging-behavior-a-new-perspective-on-gambling
#11
Merideth A Addicott, John M Pearson, Nicole Kaiser, Michael L Platt, F Joseph McClernon
Why do people gamble? Conventional views hold that gambling may be motivated by irrational beliefs, risk-seeking, impulsive temperament, or dysfunction within the same reward circuitry affected by drugs of abuse. An alternate, unexplored perspective is that gambling is an extension of natural foraging behavior to a financial environment. However, when these foraging algorithms are applied to stochastic gambling outcomes, undesirable results may occur. To test this hypothesis, we recruited participants based on their frequency of gambling-yearly (or less), monthly, and weekly-and investigated how gambling frequency related to irrational beliefs, risk-taking/impulsivity, and foraging behavior...
October 2015: Behavioral Neuroscience
https://www.readbyqxmd.com/read/26189679/wireless-optofluidic-systems-for-programmable-in-vivo-pharmacology-and-optogenetics
#12
Jae-Woong Jeong, Jordan G McCall, Gunchul Shin, Yihui Zhang, Ream Al-Hasani, Minku Kim, Shuo Li, Joo Yong Sim, Kyung-In Jang, Yan Shi, Daniel Y Hong, Yuhao Liu, Gavin P Schmitz, Li Xia, Zhubin He, Paul Gamble, Wilson Z Ray, Yonggang Huang, Michael R Bruchas, John A Rogers
In vivo pharmacology and optogenetics hold tremendous promise for dissection of neural circuits, cellular signaling, and manipulating neurophysiological systems in awake, behaving animals. Existing neural interface technologies, such as metal cannulas connected to external drug supplies for pharmacological infusions and tethered fiber optics for optogenetics, are not ideal for minimally invasive, untethered studies on freely behaving animals. Here, we introduce wireless optofluidic neural probes that combine ultrathin, soft microfluidic drug delivery with cellular-scale inorganic light-emitting diode (μ-ILED) arrays...
July 30, 2015: Cell
https://www.readbyqxmd.com/read/26135244/valuing-child-health-utility-9d-health-states-with-young-adults-insights-from-a-time-trade-off-study
#13
Julie Ratcliffe, Gang Chen, Katherine Stevens, Sandra Bradley, Leah Couzner, John Brazier, Michael Sawyer, Rachel Roberts, Elisabeth Huynh, Terry Flynn
OBJECTIVES: In contrast to the proliferation of studies incorporating health state values from adults of all ages, relatively few studies have reported upon the application of the time trade off (TTO) approach to generate health state values from populations of younger adults. This study sought to employ a conventional TTO approach to obtain values for a selection of Child Health Utility 9D (CHU9D) health states from a sample of young adults aged 18-29 years and to compare with the values generated from application of the original UK adult standard gamble scoring algorithm and the Australian adolescent scoring algorithm...
October 2015: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/25957927/clinical-trials-of-n-acetylcysteine-in-psychiatry-and-neurology-a-systematic-review
#14
REVIEW
Deepmala, John Slattery, Nihit Kumar, Leanna Delhey, Michael Berk, Olivia Dean, Charles Spielholz, Richard Frye
N-acetylcysteine (NAC) is recognized for its role in acetaminophen overdose and as a mucolytic. Over the past decade, there has been growing evidence for the use of NAC in treating psychiatric and neurological disorders, considering its role in attenuating pathophysiological processes associated with these disorders, including oxidative stress, apoptosis, mitochondrial dysfunction, neuroinflammation and glutamate and dopamine dysregulation. In this systematic review we find favorable evidence for the use of NAC in several psychiatric and neurological disorders, particularly autism, Alzheimer's disease, cocaine and cannabis addiction, bipolar disorder, depression, trichotillomania, nail biting, skin picking, obsessive-compulsive disorder, schizophrenia, drug-induced neuropathy and progressive myoclonic epilepsy...
August 2015: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/25772666/incretin-based-medications-for-type-2-diabetes-an-overview-of-reviews
#15
REVIEW
J-M Gamble, A Clarke, K J Myers, M D Agnew, K Hatch, M M Snow, E M Davis
AIMS: To summarize evidence from and assess the quality of published systematic reviews evaluating the safety, efficacy and effectiveness of incretin-based medications used in the treatment of type 2 diabetes. METHODS: We identified systematic reviews of randomized controlled trials or observational studies published in any language that evaluated the safety and/or effectiveness of glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl-peptidase-4 (DPP-4) inhibitors...
July 2015: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/25764311/comparison-of-the-management-and-in-hospital-outcomes-of-acute-coronary-syndrome-patients-in-australia-and-new-zealand-results-from-the-binational-snapshot-acute-coronary-syndrome-2012-audit
#16
COMPARATIVE STUDY
C Ellis, C Hammett, I Ranasinghe, J French, T Briffa, G Devlin, J Elliott, J Lefkovitz, B Aliprandi-Costa, C Astley, J Redfern, T Howell, B Carr, K Lintern, S Bloomer, A Farshid, P Matsis, A Hamer, M Williams, R Troughton, M Horsfall, K Hyun, G Gamble, H White, D Brieger, D Chew
BACKGROUND/AIMS: We aimed to assess differences in patient management, and outcomes, of Australian and New Zealand patients admitted with a suspected or confirmed acute coronary syndrome (ACS). METHODS: We used comprehensive data from the binational Australia and New Zealand ACS 'SNAPSHOT' audit, acquired on individual patients admitted between 00.00 h on 14 May 2012 to 24.00 h on 27 May 2012. RESULTS: There were 4387 patient admissions, 3381 (77%) in Australia and 1006 (23%) in New Zealand; Australian patients were slightly younger (67 vs 69 years, P = 0...
May 2015: Internal Medicine Journal
https://www.readbyqxmd.com/read/25762229/comparative-cardiovascular-morbidity-and-mortality-in-patients-taking-different-insulin-regimens-for-type-2-diabetes-a-systematic-review
#17
REVIEW
Hilary I Price, Meghan D Agnew, John-Michael Gamble
OBJECTIVES: To summarise the literature evaluating the association between different insulin regimens and the incidence of cardiovascular morbidity and mortality in adults with type 2 diabetes. DESIGN: Systematic review. METHODS: Multiple biomedical databases (The Cochrane Library, PubMed, EMBASE, and International Pharmaceutical Abstracts) were searched from their inception to February 2014. References of included studies were hand searched...
2015: BMJ Open
https://www.readbyqxmd.com/read/25681479/the-characterization-of-salmonella-enterica-serotypes-isolated-from-the-scalder-tank-water-of-a-commercial-poultry-processing-plant-recovery-of-a-multidrug-resistant-heidelberg-strain
#18
Michael J Rothrock, Kimberly D Ingram, John Gamble, Jean Guard, Kellie M Cicconi-Hogan, Arthur Hinton, Kelli L Hiett
The recent multistate outbreak of a multidrug-resistant (MDR) Salmonella Heidelberg strain from commercial poultry production highlights the need to better understand the reservoirs of these zoonotic pathogens within the commercial poultry production and processing environment. As part of a larger study looking at temporal changes in microbial communities within the major water tanks within a commercial processing facility, this paper identifies and characterizes Salmonella enterica isolated from the water in a final scalder tank at 3 times during a typical processing day: prior to the birds entering the tank (start), halfway through the processing day (mid), and after the final birds were scalded (end)...
March 2015: Poultry Science
https://www.readbyqxmd.com/read/25596665/limited-impact-of-drug-exposure-misclassification-from-non-benefit-thiazolidinedione-drug-use-on-mortality-and-hospitalizations-from-saskatchewan-canada-a-cohort-study
#19
MULTICENTER STUDY
John-Michael Gamble, Jeffrey A Johnson, Finlay A McAlister, Sumit R Majumdar, Scot H Simpson, Dean T Eurich
PURPOSE: Our purpose was to measure the effect of non-benefit drug use on observed associations between exposure and outcome, thereby documenting an empirical example of the potential magnitude of biases introduced when exposure status is misclassified from a restrictive drug coverage policy. METHODS: New users of antidiabetic agents were identified with a 1-year washout period between January 1, 1995, and December 31, 2005, in Saskatchewan, Canada, and were followed until December 31, 2008...
March 1, 2015: Clinical Therapeutics
https://www.readbyqxmd.com/read/25583586/the-pathological-gambling-and-epidemiology-page-study-program-design-and-fieldwork
#20
Christian Meyer, Anja Bischof, Anja Westram, Christine Jeske, Susanna de Brito, Sonja Glorius, Daniela Schön, Sarah Porz, Diana Gürtler, Nadin Kastirke, Tobias Hayer, Frank Jacobi, Michael Lucht, Volker Premper, Reiner Gilberg, Doris Hess, Gallus Bischof, Ulrich John, Hans-Jürgen Rumpf
The German federal states initiated the "Pathological Gambling and Epidemiology" (PAGE) program to evaluate the public health relevance of pathological gambling. The aim of PAGE was to estimate the prevalence of pathological gambling and cover the heterogenic presentation in the population with respect to comorbid substance use and mental disorders, risk and protective factors, course aspects, treatment utilization, triggering and maintenance factors of remission, and biological markers. This paper describes the methodological details of the study and reports basic prevalence data...
March 2015: International Journal of Methods in Psychiatric Research
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