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https://www.readbyqxmd.com/read/28899816/enzyme-crosslinked-gene-activated-matrix-for-the-induction-of-mesenchymal-stem-cells-in-osteochondral-tissue-regeneration
#1
Yi-Hsuan Lee, Hsi-Chin Wu, Chia-Wei Yeh, Chen-Hsiang Kuan, Han-Tsung Liao, Horng-Chaung Hsu, Jui-Che Tsai, Jui-Sheng Sun, Tzu-Wei Wang
The development of osteochondral tissue engineering is an important issue for the treatment of traumatic injury or aging associated joint disease. However, the different compositions and mechanical properties of cartilage and subchondral bone show the complexity of this tissue interface, making it challenging for the design and fabrication of osteochondral graft substitute. In this study, a bilayer scaffold is developed to promote the regeneration of osteochondral tissue within a single integrated construct...
September 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28886126/validation-of-the-18-gene-classifier-as-a-prognostic-biomarker-of-distant-metastasis-in-breast-cancer
#2
Skye Hung-Chun Cheng, Tzu-Ting Huang, Yu-Hao Cheng, Tee Benita Kiat Tan, Chen-Fang Horng, Yong Alison Wang, Nicholas Shannon Brian, Li-Sun Shih, Ben-Long Yu
We validated an 18-gene classifier (GC) initially developed to predict local/regional recurrence after mastectomy in estimating distant metastasis risk. The 18-gene scoring algorithm defines scores as: <21, low risk; ≥21, high risk. Six hundred eighty-three patients with primary operable breast cancer and fresh frozen tumor tissues available were included. The primary outcome was the 5-year probability of freedom from distant metastasis (DMFP). Two external datasets were used to test the predictive accuracy of 18-GC...
2017: PloS One
https://www.readbyqxmd.com/read/28867483/construction-of-a-versatile-expression-library-for-all-human-single-pass-transmembrane-proteins-for-receptor-pairings-by-high-throughput-screening
#3
Wei Yang, Søren Berg Padkjær, Jishu Wang, Zhe Sun, Bing Shan, Li Yang, Haibin Chen, Lishan Kang, Dennis Madsen, Xun Li, Chenxi Shen, Bingke Yu, Haisun Zhu, Tzu-Yuan Chao, Zhuoxiao Cao, Dapeng Li, Wei Liu, Yanping Du, Jinjing Xu, Dongxia Hao, Fengting Xu, Lujia Peng, Tengkun Li, Lin Wang, Lin Li, Haimei Xing, Di Liu, Zibing Liu, Zhishuang Guan, Wan Wang, Hong Cheng, Henrik Østergaard, Chihchuan Chang, Zhiru Yang, Esper Boel, Jing Su
Interactions between protein ligands and receptors play crucial roles in cell-cell signalling. Most of the human cell surface receptors have been identified in the post-Human Genome Project era but many of their corresponding ligands remain unknown. To facilitate the pairing of orphan receptors, 2762 sequences encoding all human single-pass transmembrane proteins were selected for inclusion into a mammalian-cell expression library. This expression library, consisting of all the individual extracellular domains (ECDs), was constructed as a Fab fusion for each protein...
September 1, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28793915/the-functional-property-of-royal-jelly-10-hydroxy-2-decenoic-acid-as-a-melanogenesis-inhibitor
#4
Chi-Chung Peng, Hui-Tzu Sun, I-Ping Lin, Ping-Chung Kuo, Jen-Chieh Li
BACKGROUND: It has been reported that royal jelly would reduce melanin synthesis and inhibit the expression of melanogensis related proteins and genes. In this study, we evaluate the anti-melanogenic and depigmenting activity of 10-hydroxy-2-decenoic acid (10-HDA) from royal jelly of Apis mellifera. METHODS: In this study, we assesses the 10-HDA whitening activity in comparison with the changes in the intracellular tyrosinase activity, melanin content and melanin production related protein levles in B16F1 melanoma cells after treating with 10-HDA...
August 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28758303/the-periodontal-war-microbes-and-immunity
#5
REVIEW
Jeffrey L Ebersole, Dolph Dawson, Pinar Emecen-Huja, Radhakrishnan Nagarajan, Katherine Howard, Martha E Grady, Katherine Thompson, Rebecca Peyyala, Ahmad Al-Attar, Kathryn Lethbridge, Sreenatha Kirakodu, Octavio A Gonzalez
Maintenance of periodontal health or transition to a periodontal lesion reflects the continuous and ongoing battle between the vast microbial ecology in the oral cavity and the array of resident and emigrating inflammatory/immune cells in the periodontium. This war clearly signifies many 'battlefronts' representing the interface of the mucosal-surface cells with the dynamic biofilms composed of commensal and potential pathogenic species, as well as more recent knowledge demonstrating active invasion of cells and tissues of the periodontium leading to skirmishes in connective tissue, the locality of bone and even in the local vasculature...
October 2017: Periodontology 2000
https://www.readbyqxmd.com/read/28709839/fungal-immunomodulatory-protein-fve-could-modulate-airway-remodel-through-by-affect-il17-cytokine
#6
Yu-Tzu Lee, Chia-Ta Wu, Hai-Lun Sun, Jiunn-Liang Ko, Ko-Haung Lue
BACKGROUND: Asthma is one of the most common allergic diseases. Our previous studies have reported that FIP-fve in acute allergic mouse model can reduce inflammation, improve the balance of the Th1/Th2 system. However, the effects of reducing airway remodeling on FIP-fve is still unknown. OBJECTIVE: We hypothesized that orally administrated FIP-fve should be able to reduce airway remodeling in chronic allergic models. METHODS: The chronic asthma animal model was established with 6-8 weeks female Balb/c mice...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28692255/cloning-expression-and-the-effects-of-processing-on-sarcoplasmic-calcium-binding-protein-an-important-allergen-in-mud-crab
#7
Meng-Jun Hu, Guang-Yu Liu, Yang Yang, Tzu-Ming Pan, Yi-Xiang Liu, Le-Chang Sun, Min-Jie Cao, Guang-Ming Liu
Shellfish allergy is a prevalent, long-lasting disorder usually persisting throughout life. However, the allergen information is incomprehensive in crab. This study aimed to identify a novel allergen in crab, show its potential in diagnosis and reduce the allergenicity by food processing. A 21-kDa protein was purified from Scylla paramamosain and confirmed as sarcoplasmic calcium binding protein (SCP) by matrix-assisted laser desorption ionization-time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/TOF-MS)...
August 2, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28676694/resonant-dipolar-coupling-of-microwaves-with-confined-acoustic-vibrations-in-a-rod-shaped-virus
#8
Chi-Kuang Sun, Yi-Chun Tsai, Yi-Jan E Chen, Tzu-Ming Liu, Hui-Yuan Chen, Han-Ching Wang, Chu-Fang Lo
In this letter, we treat a rod-shaped virus as a free homogenous nanorod and identify its confined acoustic vibration modes that can cause strong resonant microwave absorption through electric dipolar excitation with a core-shell charge distribution. They are found to be the n = 4N-2 modes of the longitudinal modes of the nanorods, where N is an integer starting from 1 and n is the mode order quantum number. This study was confirmed by measuring the microwave absorption spectra of white spot syndrome virus (WSSV), which is a rod-shaped virus...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622093/suppressive-effect-of-dengue-virus-envelope-protein-domain-iii-on-megakaryopoiesis
#9
Guan-Ling Lin, Hsin-Hou Chang, Te-Sheng Lien, Po-Kong Chen, Hao Chan, Mei-Tzu Su, Chi-Yuan Liao, Der-Shan Sun
Dengue virus (DENV) infection can cause severe, life-threatening events, and no specific treatments of DENV infection are currently approved. Although thrombocytopenia is frequently observed in dengue patients, its pathogenesis is still not fully understood. Previous studies have suggested that DENV-induced thrombocytopenia occurs through viral-replication-mediated megakaryopoiesis inhibition in the bone marrow; however, the exact mechanism for megakaryopoiesis suppression remains elusive. In this study, a reductionist approach was applied, in which C57B/6J mice were inoculated with recombinant DENV-envelope protein domain III (DENV-EIII) instead of the full viral particle...
June 16, 2017: Virulence
https://www.readbyqxmd.com/read/28606810/tailored-design-of-multifunctional-and-programmable-ph-responsive-self-assembling-polypeptides-as-drug-delivery-nanocarrier-for-cancer-therapy
#10
Tzu-Wei Wang, Chia-Wei Yeh, Chen-Hsiang Kuan, Li-Wen Wang, Liang-Hsin Chen, Hsi-Chin Wu, Jui-Shen Sun
Breast cancer has become the second leading cause of cancer-related mortality in female wherein more than 90% of breast cancer-related death results from cancer metastasis to distant organs at advanced stage. The purpose of this study is to develop biodegradable nanoparticles composed of natural polypeptides and calcium phosphate (CaP) with sequential pH-responsivity to tumor microenvironments for active targeted drug delivery. Two different amphiphilic copolymers, poly(ethylene glycol)3400-aconityl linkage-poly(l-glutamic acid)15-poly(l-histidine)10-poly(l-leucine)10 and LyP1-poly(ethylene glycol)1100-poly(l-glutamic acid)15-poly(l-histidine)10-poly(l-leucine)10, were exploited to self-assemble into micelles in aqueous phase...
June 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28513731/ag-au-nanoprism-metal-organic-framework-based-paper-for-extending-the-glucose-sensing-range-in-human-serum-and-urine
#11
Pin-Hsuan Huang, Chia Ping Hong, Jian Fan Zhu, Tzu-Ting Chen, Chu-Ting Chan, Yu-Chien Ko, Tien-Li Lin, Zheng-Bang Pan, Ning-Kuei Sun, Ying-Chu Wang, Jong-Jheng Luo, Tzu-Chieh Lin, Chia-Cheng Kang, Jing-Jong Shyue, Mei-Lin Ho
In this work, we present a Ag@Au nanoprism-metal-organic framework-paper based glucose sensor for rapid, sensitive, single-use and quantitative glucose determination in human serum. To achieve painless measurement of glucose with a non-invasive detection methodology, this biosensor was further tested in human urine. In this approach, a new hybrid-Ag@Au nanoprism loaded in close proximity to micrometer sized coordination polymers as phosphorescent luminophores significantly enhanced the emission intensity due to metal-enhanced phosphorescence and worked as reaction sites to support more dissolved oxygen...
May 30, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28501124/effects-of-endotoxin-absorber-hemoperfusion-on-microcirculation-in-septic-pigs
#12
Yu-Chang Yeh, Linda Chia-Hui Yu, Chun-Yu Wu, Ya-Jung Cheng, Chen-Tse Lee, Wei-Zen Sun, Jui-Chang Tsai, Tzu-Yu Lin
BACKGROUND: Endotoxins contribute to systemic inflammatory response and microcirculatory dysfunctions under conditions of sepsis. Polymyxin B hemoperfusion (PMX-HP) is used to remove circulating endotoxins and improve clinical outcomes. This study aims to investigate the effect of PMX-HP on microcirculation in septic pigs. MATERIALS AND METHODS: By using a septic pig model, we tested the hypothesis that PMX-HP can correct intestinal microcirculation, tissue oxygenation saturation, and histopathologic alterations...
May 1, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28410414/phthalate-exposure-and-reproductive-hormones-and-sex-hormone-binding-globulin-before-puberty-phthalate-contaminated-foodstuff-episode-in-taiwan
#13
Hui-Ju Wen, Chu-Chih Chen, Ming-Tsang Wu, Mei-Lien Chen, Chien-Wen Sun, Wen-Chiu Wu, I-Wen Huang, Po-Chin Huang, Tzu-Yun Yu, Chao A Hsiung, Shu-Li Wang
BACKGROUND: In May 2011, a major incident involving phthalates-contaminated foodstuffs occurred in Taiwan. Di-(2-ethylhexyl) phthalate (DEHP) was added to foodstuffs, mainly juice, jelly, tea, sports drink, and dietary supplements. Concerns arose that normal pubertal development, especially reproductive hormone regulation in children, could be disrupted by DEHP exposure. OBJECTIVE: To investigate the association between phthalate exposure and reproductive hormone levels among children following potential exposure to phthalate-tainted foodstuffs...
2017: PloS One
https://www.readbyqxmd.com/read/28212183/cxcl12-cxcr4-signaling-contributes-to-the-pathogenesis-of-opioid-tolerance-a-translational-study
#14
Chih-Peng Lin, Kai-Hsiang Kang, Huang-Ju Tu, Ming-Yueh Wu, Tzu-Hung Lin, Houng-Chi Liou, Wei-Zen Sun, Wen-Mei Fu
BACKGROUND: Long-term opioid therapy for chronic pain may lead to analgesic tolerance, especially when administered intrathecally, thus preventing adequate pain relief. Discovering drug targets to treat opioid tolerance using a mechanism-based approach targeting opioid-induced neuroinflammation provides new therapeutic opportunities. In this study, we provide translational evidence that CXCL12/CXCR4 signaling contributes to the pathogenesis of opioid tolerance. METHODS: The CXCL12 levels in the cerebrospinal fluid of opioid-tolerant patients were compared with those of opioid-naive subjects...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28032914/pleomorphic-mantle-cell-lymphoma-morphologically-mimicking-diffuse-large-b-cell-lymphoma-common-cyclin-d1-negativity-and-a-simple-immunohistochemical-algorithm-to-avoid-the-diagnostic-pitfall
#15
Wen-Yu Chuang, Hung Chang, Gwo-Jyh Chang, Tzu-Hao Wang, Yu-Sun Chang, Tong-Hong Wang, Chi-Ju Yeh, Shir-Hwa Ueng, Hui-Ping Chien, Chiu-Yueh Chang, Yung-Liang Wan, Chuen Hsueh
AIMS: To characterize the clinicopathological and genetic features of pleomorphic mantle cell lymphoma (PMCL), which morphologically mimics diffuse large B cell lymphoma (DLBCL). METHODS AND RESULTS: We screened systematically 500 B cell lymphomas morphologically compatible with DLBCL using an immunohistochemical algorithm of three markers (CD5, cyclin D1 and SOX11). Ten cases of PMCL were identified for further study and, surprisingly, four (40%) of them were cyclin D1-negative...
May 2017: Histopathology
https://www.readbyqxmd.com/read/27872410/risk-of-mortality-of-catheter-related-bloodstream-infections-caused-by-acinetobacter-species
#16
Yi Lee, Yi-Tzu Lee, Yung-Chih Wang, Chung-Ting Chen, Jun-Ren Sun, Chang-Pan Liu, Yuan-Meng Liu, Shu-Chen Kuo, Chun-Hsiang Chiu, Ya-Sung Yang, Jung-Chung Lin, Te-Li Chen
PURPOSE: Bloodstream infections (BSIs) caused by Acinetobacter species have been extensively reported, however, which majorly focused on respiratory tract infections. The risk of mortality and the effect of early catheter removal on survival in catheter-related BSIs (CRBSIs) caused by Acinetobacter spp. remain unclear. This study aims to investigate that. METHODS: This is a retrospective multicentric study conducted in Taiwan from 2012 to 2014. Patients with at least 1 positive blood culture and catheter culture for the same Acinetobacter spp...
January 1, 2016: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/27793268/spontaneous-metastases-in-immunocompetent-mice-harboring-a-primary-tumor-driven-by-oncogene-latent-membrane-protein-1-from-epstein-barr-virus
#17
Pu-Yuan Chang, Yenlin Huang, Tzu-Yuan Hung, Kowit-Yu Chong, Yu-Sun Chang, Chuck C-K Chao, Kai-Ping N Chow
BACKGROUND: In vitro and clinical studies suggest that the oncogene LMP1 (latent membrane protein 1) encoded by Epstein-Barr virus (EBV) plays a role in the development of nasopharyngeal carcinoma (NPC) and the formation of metastases in immunocompetent individuals. However, whether LMP1 itself is sufficient to drive these events in immunocompetent hosts remains elusive due to the lack of appropriate experimental models. The aim of this study was to study LMP1-dependent tumorigenesis and metastasis in BALB/c mice inoculated with BALB/c-3T3 cells expressing N-LMP1 (a Taiwanese NPC variant)...
August 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27758765/amp-activated-protein-kinase-and-sirtuin-1-coregulation-of-cortactin-contributes-to-endothelial-function
#18
Tzu-Pin Shentu, Ming He, Xiaoli Sun, Jianlin Zhang, Fan Zhang, Brendan Gongol, Traci L Marin, Jiao Zhang, Liang Wen, Yinsheng Wang, Gregory G Geary, Yi Zhu, David A Johnson, John Y-J Shyy
OBJECTIVE: Cortactin translocates to the cell periphery in vascular endothelial cells (ECs) on cortical-actin assembly in response to pulsatile shear stress. Because cortactin has putative sites for AMP-activated protein kinase (AMPK) phosphorylation and sirtuin 1 (SIRT1) deacetylation, we examined the hypothesis that AMPK and SIRT1 coregulate cortactin dynamics in response to shear stress. APPROACH AND RESULTS: Analysis of the ability of AMPK to phosphorylate recombinant cortactin and oligopeptides whose sequences matched AMPK consensus sequences in cortactin pointed to Thr-401 as the site of AMPK phosphorylation...
December 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27738429/mixed-infections-of-helicobacter-pylori-isolated-from-patients-with-gastrointestinal-diseases-in-taiwan
#19
Chih-Ho Lai, Ju-Chun Huang, Chuan Chiang-Ni, Ju-Pi Li, Lii-Tzu Wu, Hua-Shan Wu, Yu-Chen Sun, Mei-Ling Lin, Ju-Fang Lee, Hwai-Jeng Lin
Background. Persistent Helicobacter pylori infection may induce several upper gastrointestinal diseases. Two major virulence factors of H. pylori, vacuolating cytotoxin A (VacA) and cytotoxin-associated gene A (CagA), are thought to be associated with the severity of disease progression. The distribution of vacA and cag-pathogenicity island (cag-PAI) alleles varies in H. pylori isolated from patients in different geographic regions. Aim. To assess the association between mixed infection of H. pylori clinical isolates from Taiwanese patients and the severity of gastrointestinal diseases...
2016: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/27663741/saliva-protein-biomarkers-to-detect-oral-squamous-cell-carcinoma-in-a-high-risk-population-in-taiwan
#20
Jau-Song Yu, Yi-Ting Chen, Wei-Fan Chiang, Yung-Chin Hsiao, Lichieh Julie Chu, Lai-Chu See, Chi-Sheng Wu, Hui-Tzu Tu, Hsiao-Wei Chen, Chia-Chun Chen, Wei-Chao Liao, Ya-Ting Chang, Chih-Ching Wu, Che-Yi Lin, Shyun-Yeu Liu, Shu-Ti Chiou, Shu-Li Chia, Kai-Ping Chang, Chih-Yen Chien, Su-Wei Chang, Chee-Jen Chang, John D Young, Chia C Pao, Yu-Sun Chang, Leland H Hartwell
Most cases of oral squamous cell carcinoma (OSCC) develop from visible oral potentially malignant disorders (OPMDs). The latter exhibit heterogeneous subtypes with different transformation potentials, complicating the early detection of OSCC during routine visual oral cancer screenings. To develop clinically applicable biomarkers, we collected saliva samples from 96 healthy controls, 103 low-risk OPMDs, 130 high-risk OPMDs, and 131 OSCC subjects. These individuals were enrolled in Taiwan's Oral Cancer Screening Program...
October 11, 2016: Proceedings of the National Academy of Sciences of the United States of America
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