keyword
https://read.qxmd.com/read/38630385/exploring-management-and-outcomes-of-elderly-patients-with-glioblastoma-using-data-from-two-randomised-trials-geino1401-ex-tem
#21
JOURNAL ARTICLE
Lucy Gately, C Mesía, J M Sepúlveda, S Del Barco, E Pineda, R Gironés, J Fuster, M Dumas, S Gill, L M Navarro, A Herrero, A Dowling, R de Las Peñas, M A Vaz, M Alonso, Z Lwin, R Harrup, S Peralta, A Long, P Perez-Segura, E Ahern, C O Garate, M Wong, R Campbell, K Cuff, R Jennens, O Gallego, C Underhill, M Martinez-Garcia, M Covela, A Cooper, S Brown, M Rosenthal, J Torres, I M Collins, P Gibbs, C Balana
PURPOSE: The impact of age on optimal management of glioblastoma remains unclear. A recent combined analysis of two randomised trials, GEINO14-01 and EX-TEM, found no benefit from extending post-radiation temozolomide in newly diagnosed glioblastoma. Here, we explore the impact of age. METHODS: Relevant intergroup statistics were used to identify differences in tumour, treatment and outcome characteristics based on age with elderly patients (EP) defined as age 65 years and over...
April 17, 2024: Journal of Neuro-oncology
https://read.qxmd.com/read/38630333/trends-in-ototoxicity-monitoring-among-cisplatin-treated-patients-with-cancer
#22
JOURNAL ARTICLE
David S Lee, Emma Y Travis, Susan K Wong, Marie-Ange Munyemana, Lauren Mueller, Cathryn Collopy Rowling, Jason T Rich, Patrik Pipkorn, Sidharth V Puram, Ryan S Jackson, Douglas R Adkins, Peter Oppelt, Wade L Thorstad, Cameron C Wick, Jose P Zevallos, Kate McClannahan, Angela L Mazul
PURPOSE: This study aims to characterize patterns in ototoxicity monitoring and identify potential barriers to audiologic follow-up. METHODS: We performed a single-institution retrospective cohort study on adult (≥ 18 years old) cancer patients treated with cisplatin from January 2014 to September 2021. Our primary outcomes were rates of baseline and post-treatment audiograms at the following time points: 3, 6, 12, and greater than 12 months...
April 17, 2024: Journal of Cancer Survivorship: Research and Practice
https://read.qxmd.com/read/38630328/isolated-dentinogenesis-imperfecta-novel-dspp-variants-and-insights-on-genetic-counselling
#23
JOURNAL ARTICLE
Nehal F Hassib, Mennat Mehrez, Mostafa I Mostafa, Mohamed S Abdel-Hamid
OBJECTIVE: Dentinogenesis imperfecta (DI) is an inherited dentin defect and may be isolated or associated with disorders such as osteogenesis imperfecta, odontochondrodysplasia Ehler-Danlos and others. Isolated DI is caused mainly by pathogenic variants in DSPP gene and around 50 different variants have been described in this gene. Herein, we report on 19 patients from two unrelated Egyptian families with isolated DI. Additionally, we focused on genetic counselling of the two families...
April 17, 2024: Clinical Oral Investigations
https://read.qxmd.com/read/38630327/functional-expression-purification-biochemical-and-biophysical-characterizations-and-molecular-dynamics-simulation-of-a-histidine-acid-phosphatase-from-saccharomyces-cerevisiae
#24
JOURNAL ARTICLE
Nima Ghahremani Nezhad, Siti Zahra Binti Jamaludin, Raja Noor Zaliha Raja Abd Rahman, Normi Mohd Yahaya, Siti Nurbaya Oslan, Fairolniza Mohd Shariff, Nurulfiza Mat Isa, Thean Chor Leow
A histidine acid phosphatase (HAP) (PhySc) with 99.50% protein sequence similarity with PHO5 from Saccharomyces cerevisiae was expressed functionally with the molecular mass of ∼110 kDa through co-expression along with the set of molecular chaperones dnaK, dnaJ, GroESL. The purified HAP illustrated the optimum activity of 28.75 ± 0.39 U/mg at pH 5.5 and 40 ˚C. The Km and Kcat values towards calcium phytate were 0.608 ± 0.09 mM and 650.89 ± 3...
April 17, 2024: World Journal of Microbiology & Biotechnology
https://read.qxmd.com/read/38630316/teneurin-c-terminal-associated-peptide-tcap-1-attenuates-the-development-and-expression-of-naloxone-precipitated-morphine-withdrawal-in-male-swiss-webster-mice
#25
JOURNAL ARTICLE
Lauren E Mueller, Roseanne S Wexler, David A Lovejoy, Robert B Stein, Andrew M Slee
RATIONALE: Corticotropin-releasing factor (CRF), the apical stress-inducing hormone, exacerbates stress and addictive behaviors. TCAP-1 is a peptide that directly inhibits both CRF-mediated stress and addiction-related behaviors; however, the direct action of TCAP-1 on morphine withdrawal-associated behaviors has not previously been examined. OBJECTIVE: To determine whether TCAP-1 administration attenuates behavioral and physiological consequences of morphine withdrawal in mice...
April 17, 2024: Psychopharmacology
https://read.qxmd.com/read/38630247/relating-preoperative-mcs-12-to-microdiscectomy-outcomes
#26
JOURNAL ARTICLE
Jeremy C Heard, Yunsoo Lee, Teeto Ezeonu, Mark J Lambrechts, Rajkishen Narayanan, Caleb Yeung, Justin Wright, John Paulik, Caroline Purtill, John J Mangan, Mark F Kurd, Ian D Kaye, Jose A Canseco, Alan S Hilibrand, Alexander R Vaccaro, Gregory D Schroeder, Christopher K Kepler
PURPOSE: To determine the impact of poor mental health on patient-reported and surgical outcomes after microdiscectomy. METHODS: Patients ≥ 18 years who underwent a single-level lumbar microdiscectomy from 2014 to 2021 at a single academic institution were retrospectively identified. Patient-reported outcomes (PROMs) were collected at preoperative, three-month, and one-year postoperative time points. PROMs included the Oswestry Disability Index (ODI), Visual Analog Scale Back and Leg (VAS Back and VAS Leg, respectively), and the mental and physical component of the short form-12 survey (MCS and PCS)...
April 17, 2024: European Spine Journal
https://read.qxmd.com/read/38630213/italian-guidelines-for-the-management-of-adult-individuals-with-overweight-and-obesity-and-metabolic-comorbidities-that-are-resistant-to-behavioral-treatment
#27
JOURNAL ARTICLE
M Chianelli, L Busetto, R Vettor, B Annibale, A Paoletta, E Papini, A Albanese, M Carabotti, D Casarotto, G De Pergola, O E Disoteo, I Grandone, G Medea, E Nisoli, M Raffaelli, S Schiff, F Vignati, M Cinquini, M Gonzalez-Lorenzo, V A Fittipaldo, S Minozzi, M Monteforte, A C Tralongo, R Novizio, A Persichetti, I Samperi, A Scoppola, G Borretta, M Carruba, M G Carbonelli, M De Luca, S Frontoni, S G Corradini, F Muratori, R Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of adult patients with overweight or obesity associated with metabolic complications who are resistant to lifestyle modification. METHODS: Surgeons, endocrinologists, gastroenterologists, psychologists, pharmacologists, a general practitioner, a nutritionist, a nurse and a patients' representative acted as multi-disciplinary panel. This GL has been developed following the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach...
April 17, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38630189/phylodynamic-analysis-of-foot-and-mouth-disease-virus-evolution-in-mar-chiquita-argentina
#28
JOURNAL ARTICLE
Laura C Lozano Calderón, Gustavo S Cabanne, Andrea Marcos, Sabrina Galdo Novo, Carolina Torres, Andrés M Perez, Oliver G Pybus, Guido A König
Foot-and-mouth disease is a highly contagious disease affecting cloven-hoofed animals, resulting in considerable economic losses. Its causal agent is foot-and-mouth disease virus (FMDV), a picornavirus. Due to its error-prone replication and rapid evolution, the transmission and evolutionary dynamics of FMDV can be studied using genomic epidemiological approaches. To analyze FMDV evolution and identify possible transmission routes in an Argentinean region, field samples that tested positive for FMDV by PCR were obtained from 21 farms located in the Mar Chiquita district...
April 17, 2024: Archives of Virology
https://read.qxmd.com/read/38630178/the-performance-of-artificial-intelligence-large-language-model-linked-chatbots-in-surgical-decision-making-for-gastroesophageal-reflux-disease
#29
JOURNAL ARTICLE
Bright Huo, Elisa Calabrese, Patricia Sylla, Sunjay Kumar, Romeo C Ignacio, Rodolfo Oviedo, Imran Hassan, Bethany J Slater, Andreas Kaiser, Danielle S Walsh, Wesley Vosburg
BACKGROUND: Large language model (LLM)-linked chatbots may be an efficient source of clinical recommendations for healthcare providers and patients. This study evaluated the performance of LLM-linked chatbots in providing recommendations for the surgical management of gastroesophageal reflux disease (GERD). METHODS: Nine patient cases were created based on key questions addressed by the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) guidelines for the surgical treatment of GERD...
April 17, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38630048/mechanisms-of-spinophilin-dependent-pancreas-dysregulation-in-obesity
#30
JOURNAL ARTICLE
Kaitlyn C Stickel, Nikhil R Shah, Emily T Claeboe, Kara S Orr, Amber L Mosley, Emma H Doud, Teri L Belecky-Adams, Anthony J Baucum
Spinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/- ) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decreased weight gain and improved glucose tolerance in two different models of obesity...
April 17, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38629938/stable-2-azaallyl-salts-as-a-bridge-between-2-h-azirines-and-densely-functionalized-2-h-pyrroles
#31
JOURNAL ARTICLE
Julia I Pavlenko, Anastasiya V Agafonova, Pavel A Sakharov, Ilia A Smetanin, Alexander F Khlebnikov, Mariya A Kryukova, Mikhail S Novikov
An efficient protocol for the synthesis of stable 2-azaallyl anion salts by the reaction of alkyl 2-bromo-2 H -azirine-2-carboxylates with trimethylsilyl cyanide/Bu4 NF has been developed. The domino reaction proceeds in four steps via the cleavage of the azirine C-C bond to provide the tetrabutylammonium salts of stereochemically pure 2-azaallyl anions having U-configuration relative to the cyano groups. The anions with an ortho -substituted aryl group or styryl group exist as a mixture of two geometrical isomers across the N2-C3 bond...
April 17, 2024: Journal of Organic Chemistry
https://read.qxmd.com/read/38629936/minocycline-to-reduce-inflammation-and-blood-brain-barrier-leakage-in-small-vessel-disease-minerva-a-phase-ii-randomized-double-blind-placebo-controlled-experimental-medicine-trial
#32
JOURNAL ARTICLE
Robin B Brown, Daniel J Tozer, Laurence Loubière, Eric L Harshfield, Young T Hong, Tim D Fryer, Guy B Williams, Martin J Graves, Franklin I Aigbirhio, John T O'Brien, Hugh S Markus
INTRODUCTION: Cerebral small vessel disease (SVD) is a common cause of stroke/vascular dementia with few effective treatments. Neuroinflammation and increased blood-brain barrier (BBB) permeability may influence pathogenesis. In rodent models, minocycline reduced inflammation/BBB permeability. We determined whether minocycline had a similar effect in patients with SVD. METHODS: MINERVA was a single-center, phase II, randomized, double-blind, placebo-controlled trial...
April 17, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/38629928/new-dynamic-diamond-anvil-cell-for-time-resolved-radial-x-ray-diffraction
#33
JOURNAL ARTICLE
L Q Huston, L Miyagi, R J Husband, K Glazyrin, C Kiessner, M Wendt, H P Liermann, B T Sturtevant
The dynamic diamond anvil cell (dDAC) is a recently developed experimental platform that has shown promise for studying the behavior of materials at strain rates ranging from intermediate to quasi-static and shock compression regimes. Combining dDAC with time-resolved x-ray diffraction (XRD) in the radial geometry (i.e., with incident x-rays perpendicular to the axis of compression) enables the study of material properties such as strength, texture evolution, and deformation mechanisms. This work describes a radial XRD dDAC setup at beamline P02...
April 1, 2024: Review of Scientific Instruments
https://read.qxmd.com/read/38629926/aligning-the-thomson-scattering-and-charge-exchange-recombination-diagnostics-using-neutral-beam-emission-at-diii-d
#34
JOURNAL ARTICLE
A Feyrer, S R Haskey, C Chrystal, C A Aidala
This work addresses discrepancies in the alignment of the H-mode pedestal profiles of the electron and ion properties in the DIII-D tokamak as measured by Thomson Scattering (TS) and Charge Exchange Recombination Spectroscopy (CER) diagnostics. While the alignment of these profiles is key for accurate studies of tokamak physics and plasma confinement, misalignments can occur due to inaccuracies, such as in magnetic equilibrium reconstructions required to map measurements in different poloidal and toroidal locations...
April 1, 2024: Review of Scientific Instruments
https://read.qxmd.com/read/38629803/60-years-of-the-3rs-symposium-lessons-learned-and-the-road-ahead
#35
JOURNAL ARTICLE
Michael Balls, Rolf Bass, Rodger Curren, Julia Fentem, Alan Goldberg, Thomas Hartung, Kathrin Herrmann, Nicole C Kleinstreuer, Lisa Libowitz, John Parascandola, Andrew Rowan, Horst Spielmann, Martin L Stephens, Russell S Thomas, Katya Tsaioun
When The Principles of Humane Experimental Technique was published in 1959, authors William Russell and Rex Burch had a modest goal: to make researchers think about what they were doing in the laboratory - and to do it more humanely. Sixty years later, their groundbreaking book was celebrated for inspiring a revolution in science and launching a new field: The 3Rs of alternatives to animal experimentation. On November 22, 2019, some pioneering and leading scientists and researchers in the field gathered at the Johns Hopkins Bloomberg School of Public Health in Bal-timore for the 60 Years of the 3Rs Symposium: Lessons Learned and the Road Ahead...
2024: ALTEX
https://read.qxmd.com/read/38629740/validation-of-the-bcis-chip-score-in-chronic-total-occlusion-percutaneous-coronary-intervention
#36
JOURNAL ARTICLE
Athanasios Rempakos, Michaella Alexandrou, Deniz Mutlu, James W Choi, Paul Poommipanit, Jaikirshan J Khatri, Laura Young, Brian Jefferson, Sevket Gorgulu, Farouc A Jaffer, Raj Chandwaney, Rhian Davies, Stewart Benton, Khaldoon Alaswad, Lorenzo Azzalini, Kathleen E Kearney, Oleg Krestyaninov, Dmitrii Khelimskii, Philip Dattilo, Niranjan Reddy, Nidal Abi-Rafeh, Ahmed Elguindy, Omer Goktekin, Bavana V Rangan, Olga C Mastrodemos, Ahmed Al-Ogaili, Yader Sandoval, Nicholas M Burke, Emmanouil S Brilakis, Mir B Basir
BACKGROUND: The complex high-risk indicated percutaneous coronary intervention (CHIP) score is a tool developed using the British Cardiovascular Intervention Society (BCIS) database to define CHIP cases and predict in-hospital major adverse cardiac or cerebrovascular events (MACCE). AIM: To assess the validity of the CHIP score in chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: We evaluated the performance of the CHIP score on 8341 CTO PCIs from the Prospective Global Registry for the Study of Chronic Total Occlusion Intervention (PROGRESS-CTO) performed at 44 centers between 2012 and 2023...
April 17, 2024: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/38629678/the-physiological-quality-of-vigna-unguiculata-l-seeds-shows-tolerance-to-salinity
#37
JOURNAL ARTICLE
F H A Andrade, R T Silva, M A Barbosa Neto, S F Silva, A F L Cardoso, J S Lima, J H B Silva, A F S Cruz, M I B Clemente, E A Onias, W E Pereira, J T L Chaves, S G S Borges, A M F Oliveira, P C A Linhares, R R Silva
Salinity reduces feijão-caupi production, and the search for tolerant varieties becomes important within the agricultural context, as, in addition to being used in the field, they can be used in genetic improvement. The objective was to for a identify variety that is tolerant to salinity considering the physiological quality of seeds and seedling growth. A 2 × 4 factorial scheme was used, referring to the varieties Pingo-de-ouro and Coruja, and four electrical conductivities of water (0; 3.3; 6.6 and 9...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38629657/mercury-hg-concentration-in-fish-commercialized-in-the-s%C3%A3-o-lu%C3%A3-s-fish-market-ma-and-potential-exposure-of-consumers
#38
JOURNAL ARTICLE
Luiz D Lacerda, Victor L Moura, Rayone Wesley S Oliveira, Kevin Luiz C F Carmo, Jorge Luiz S Nunes, Arlan S Freitas, Moises F Bezerra
Fish consumption is the main path of human exposure to Hg and may represent a risk to public health, even with low Hg concentrations in fish, if consumption rates are high. This study quantifies, for the first time, the Hg concentrations in nine most commercialized species in the São Luís (MA) fish market, where fish consumption is high, and estimates human exposure. Average Hg concentrations were highest in carnivorous species, yellow hake (Cynoscion acoupa) (0.296 mg kg-1), the Atlantic croaker (Micropogonias undulatus) (0...
2024: Anais da Academia Brasileira de Ciências
https://read.qxmd.com/read/38629606/molecular-simulation-of-flow-enhanced-nucleation-of-polyethylene-crystallites-in-biaxial-flows
#39
JOURNAL ARTICLE
Chinmay S Gangal, Gregory C Rutledge
Flow-enhanced nucleation (FEN) of n-pentacontahectane (C150) under biaxial extensional flows of varying strain rate ratios is studied using nonequilibrium molecular dynamics simulation. The nucleation rates thus calculated are used to test previously published FEN models based on invariants of the conformation tensor of Kuhn segments and the extra stress tensor. Models based on the conformation tensor provide a more accurate description of FEN observed in biaxial flow simulations than those based on the extra stress tensor...
April 21, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38629581/chemical-kinetics-and-thermodynamics-of-ppo-activity-colour-changes-and-microbial-degradation-during-blanching-of-the-sugarcane-billets
#40
JOURNAL ARTICLE
Priyanka Singh, Anam, Pushpa Singh, Saachi Chaurasia, D Kumar
BACKGROUND: Sugarcane juice, which has a short shelf life, is a popular thirst-quenching and rejuvenating beverage worldwide. The limited shelf life is due to changes in polyphenol oxidase (PPO) activity, total plate count (TPC) and color attributes (L*, a* and b* values). We hypothesized that chemical kinetics and thermodynamics of blanched sugarcane cane juice causing alterations in PPO, TPC and L, a*, b* values shall address the challenges of sugarcane juice preservation. RESULT: Sugarcane billets were blanched at variable time-temperature combinations in the range of 0-20 min and 70-90°C...
April 17, 2024: Journal of the Science of Food and Agriculture
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