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https://www.readbyqxmd.com/read/28222564/neurological-and-functional-recovery-in%C3%A2-tuberculosis-patients-with-spinal-cord%C3%A2-injury-in-the-netherlands
#1
Eva M N Wouda, Ymkje Stienstra, Tjip S van der Werf, Huib Kerstjens, Wiel C M de Lange, Maarten Coppes, Jos Kuijlen, Marga Tepper, Onno W Akkerman
BACKGROUND: Spinal tuberculosis (TB) accounts for approximately 1% to 3% of all TB cases and it can cause a wide range of neurological symptoms, from none to a complete spinal cord injury (SCI), resulting in complete paraplegia or tetraplegia. OBJECTIVES: To describe the functional and neurological outcome of SCI caused by TB. METHODS: Retrospective data on the admission period was combined with prospectively collected data on long-term follow-up...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222526/the-impact-of-alzheimer-s-disease-on-the-resting-state-functional-connectivity-of-brain-regions-modulating-pain-a-cross-sectional-study
#2
Todd B Monroe, Paul A Beach, Stephen P Bruehl, Mary S Dietrich, Baxter P Rogers, John C Gore, Sebastian W Atalla, Ronald L Cowan
BACKGROUND: It is currently unknown why people with Alzheimer's disease (AD) receive less pain medication and report pain less frequently. OBJECTIVE: The purpose of this study was to determine the impact of AD on thermal psychophysics and resting-state functional connectivity (RSFC) among sensory, affective, descending modulatory, and default mode structures. METHODS: Controls (n = 23, 13 = female) and age-matched people with AD (n = 23, 13 = females) underwent psychophysical testing to rate perceptions of warmth, mild, and moderate pain and then completed resting-state fMRI...
February 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28222420/camalexin-induced-cell-membrane-scrambling-and-cell-shrinkage-in-human-erythrocytes
#3
Mustafa Almasry, Mohamed Jemaà, Morena Mischitelli, Florian Lang, Caterina Faggio
BACKGROUND/AIMS: The thaliana phytoalexin Camalexin has been proposed for the treatment of malignancy. Camalexin counteracts tumor growth in part by stimulation of suicidal death or apoptosis of tumor cells. Similar to apoptosis of nucleated cells, erythrocytes may enter suicidal death or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Cellular mechanisms contributing to the complex machinery executing eryptosis include increase of cytosolic Ca2+ activity ([Ca2+]i), oxidative stress, ceramide, protein kinase C and caspases...
February 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28222400/antiprotozoal-antimycobacterial-and-anti-inflammatory-evaluation-of-cnidoscolus-chayamansa-mc-vaugh-extract-and-the-isolated-compounds
#4
Mariana Z Pérez-González, Gabriel A Gutiérrez-Rebolledo, Lilián Yépez-Mulia, Irma S Rojas-Tomé, Julieta Luna-Herrera, María A Jiménez-Arellanes
Cnidoscolus chayamansa is a medicinal and edible plant known as Chaya, is commonly used as an anti-inflammatory, antiprotozoal, antibacterial agent and as a remedy for respiratory illness, gastrointestinal disorders, and vaginal infections related with the inflammation process. In this paper, we describe the plant's phytochemical analysis and biological activities (antimycobacterial, antibacterial, antiprotozoal, and anti-inflammatory properties) of the CHCl3:MeOH (1:1) leaves extract and isolated compounds, as well as the acute and sub-acute toxic effects...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222398/isolation-of-a-new-resorcinolic-lipid-from-mangifera-zeylanica-hook-f-bark-and-its-cytotoxic-and-apoptotic-potential
#5
Meran Keshawa Ediriweera, Kamani Hemamala Tennekoon, Sameera Ranganath Samarakoon, Achyut Adhikari, Ira Thabrew, E Dilip de Silva
Mangifera zeylanica is a plant endemic to Sri Lanka and its bark has been used in traditional medicine to treat some cancers. This study was aimed to isolate potentially cytotoxic compound/s from the hexane extract of the bark of M. zeylanica by bio-activity guided fractionation. The structure of the isolated compound (1) was elucidated using (1)H, (13)C NMR and mass spectrometric techniques. Compound 1 was identified as a new resorcinolic lipid (5-((8Z, 11Z, 14Z)-hexatriaconta-8, 11, 14-trienyl) benzene-1,3-diol)...
February 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222395/technetium-99m-radiolabeled-paclitaxel-as-an-imaging-probe-for-breast-cancer-in-vivo
#6
Liziane O F Monteiro, Renata S Fernandes, Luciano C Castro, Valbert N Cardoso, Mônica C Oliveira, Danyelle M Townsend, Alice Ferretti, Domenico Rubello, Elaine A Leite, André L B de Barros
The high incidence and mortality of breast cancer supports efforts to develop innovative imaging probes to effectively diagnose, evaluate the extent of the tumor, and predict the efficacy of tumor treatments while concurrently and selectively delivering anticancer agents to the cancer tissue. In the present study we described the preparation of technetium-99m ((99m)Tc)-labeled paclitaxel (PTX) and evaluated its feasibility as a radiotracer for breast tumors (4T1) in BALB/c mice. Thin Layer Chromatography (TLC) was used to determine the radiochemical purity and in vitro stability of (99m)Tc-PTX...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222393/caffeine-prevents-changes-in-muscle-caused-by-high-intensity-interval-training
#7
Juliano M Vieira, Jessié M Gutierres, Fabiano B Carvalho, Luciane B Pereira, Liziele S Oliveira, Vera Maria Morsch, Maria Rosa C Schetinger, Marília V Rodrigues, Jossiele Leitemperger, Vânia Loro, Cristina C Krewer, Marina S Vencato, Roselia M Spanevello
The use of ergogenic substances such as caffeine has become a strategy to enhance sports performance. In the present study we evaluated the effects of high-intensity interval training (HIIT) associated with caffeine intake on acetylcholinesterase (AChE) and Ca(2+)ATPase activity and glycogen levels in the muscles of rats were evaluated. The animals were divided in groups: control, caffeine 4 or 8mg/kg, HIIT, HIIT plus caffeine 4 or caffeine 8mg/kg. Our results showed a decrease in glycogen levels in muscle in all trained groups after acute session exercise, while that an increase in glycogen levels was observed in all groups in relation to control in chronic exercise protocol...
February 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28222383/simultaneous-biogas-upgrading-and-centrate-treatment-in-an-outdoors-pilot-scale-high-rate-algal-pond
#8
Esther Posadas, David Marín, Saúl Blanco, Raquel Lebrero, Raúl Muñoz
The bioconversion of biogas to biomethane coupled to centrate treatment was evaluated in an outdoors pilot scale high rate algal pond interconnected to an external CO2-H2S absorption column (AC) via settled broth recirculation. CO2-removal efficiencies ranged from 50 to 95% depending on the alkalinity of the cultivation broth and environmental conditions, while a complete H2S removal was achieved regardless of the operational conditions. A maximum CH4 concentration of 94% with a limited O2 and N2 stripping was recorded in the upgraded biogas at recycling liquid/biogas ratios in the AC of 1 and 2...
February 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28222379/increased-static-and-decreased-capacity-oxidation-reduction-potentials-in-plasma-are-predictive-of-metabolic-syndrome
#9
Gerd Bobe, Tora J Cobb, Scott W Leonard, Savinda Aponso, Christopher B Bahro, Dipankar Koley, Eunice Mah, Richard S Bruno, Maret G Traber
Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age- and gender-matched individuals with MetS (BMI: 22...
February 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28222370/increased-postural-sway-in-persons-with-multiple-sclerosis-during-short-term-exposure-to-warm-ambient-temperatures
#10
Paula Y S Poh, Amy N Adams, Mu Huang, Dustin R Allen, Scott L Davis, Anna S Tseng, Craig G Crandall
BACKGROUND: Multiple sclerosis (MS) is a neurological disease marked by demyelination and axonal loss. Individuals with MS experience increases in clinical signs and symptoms during heat exposure. OBJECTIVE: To test the hypothesis that moderate heat exposure adversely affects postural sway in individuals with MS. METHODS: Ten individuals with relapsing-remitting MS (50±8y) and nine controls (47±10y) were examined under a Thermal and a Time Control trial...
February 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28222356/extinction-of-avoidance-behavior-by-safety-learning-depends-on-endocannabinoid-signaling-in-the-hippocampus
#11
Vincenzo Micale, Jens Stepan, Angela Jurik, Fabricio A Pamplona, Rudolph Marsch, Filippo Drago, Matthias Eder, Carsten T Wotjak
The development of exaggerated avoidance behavior is largely responsible for the decreased quality of life in patients suffering from anxiety disorders. Studies using animal models have contributed to the understanding of the neural mechanisms underlying the acquisition of avoidance responses. However, much less is known about its extinction. Here we provide evidence in mice that learning about the safety of an environment (i.e., safety learning) rather than repeated execution of the avoided response in absence of negative consequences (i...
February 3, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28222355/neuroimaging-of-major-depression-in-parkinson-s-disease-cortical-thickness-cortical-and-subcortical-volume-and-spectroscopy-findings
#12
Marcos Hortes N Chagas, Vitor Tumas, Márcio A Pena-Pereira, João Paulo Machado-de-Sousa, Antonio Carlos Dos Santos, Rafael Faria Sanches, Jaime E C Hallak, José Alexandre S Crippa
Depression is the most common psychiatric disorder in Parkinson's disease (PD). The aim of this study was to compare PD patients with current Major Depressive Disorder (MDD), lifetime MDD, and no MDD using three neuroimaging techniques. A total of 43 PD patients were selected and divided into three groups: (i) current MDD (n = 15), (ii) previous MDD without current MDD (n = 10); and (iii) control group (no current or lifetime MDD; n = 18). All participants underwent magnetic resonance imaging to evaluate cortical thickness, cortical and subcortical volume, and spectroscopy in the bilateral putamen and cingulate cortex...
February 13, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28222351/the-land-morphology-approach-to-flood-risk-mapping-an-application-to-portugal
#13
N S Cunha, M R Magalhães, T Domingos, M M Abreu, C Küpfer
In the last decades, the increasing vulnerability of floodplains is linked to societal changes such as population density growth, land use changes, water use patterns, among other factors. Land morphology directly influences surface water flow, transport of sediments, soil genesis, local climate and vegetation distribution. Therefore, the land morphology, the land used and management directly influences flood risks genesis. However, attention is not always given to the underlying geomorphological and ecological processes that influence the dynamic of rivers and their floodplains...
February 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28222335/sensitive-simultaneous-quantitation-of-testosterone-and-estradiol-in-serum-by-lc-ms-ms-without-derivatization-and-comparison-with-the-cdc-host-program
#14
Ryan C Schofield, Damodara R Mendu, Lakshmi V Ramanathan, Melissa S Pessin, Dean C Carlow
BACKGROUND: Very sensitive measurements of serum estrogens and testosterone are important in adult and pediatric endocrinology and immunoassays are known to lack the required performance at very low levels. Our aim was to develop a sensitive HPLC-MS/MS assay for both estradiol (E2) and testosterone (Te) in serum without the need for chemical derivatization and using commercially available calibrators. METHODS: Serum samples were prepared by the addition of internal standards followed by extraction using hexane:ethyl acetate...
February 10, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28222316/discovery-and-characterization-of-novel-cyp1b1-inhibitors-based-on-heterocyclic-chalcones-overcoming-cisplatin-resistance-in-cyp1b1-overexpressing-lines
#15
Neill J Horley, Kenneth J M Beresford, Tarun Chawla, Glen J P McCann, Ketan C Ruparelia, Linda Gatchie, Vinay R Sonawane, Ibidapo S Williams, Hoon L Tan, Prashant Joshi, Sonali S Bharate, Vikas Kumar, Sandip B Bharate, Bhabatosh Chaudhuri
The structure of alpha-napthoflavone (ANF), a potent inhibitor of CYP1A1 and CYP1B1, mimics the structure of chalcones. Two potent CYP1B1 inhibitors 7k (DMU2105) and 6j (DMU2139) have been identified from two series of synthetic pyridylchalcones. They inhibit human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™) with IC50 values of 10 and 9 nM, respectively, and show a very high level of selectivity towards CYP1B1 with respect to the IC50 values obtained with CYP1A1, CYP1A2, CYP3A4, CYP2D6, CYP2C9 and CYP2C19 Sacchrosomes™...
February 9, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28222273/competencies-in-european-gerontological-higher-education-an-explorative-study-on-core-elements
#16
Eric C Schoenmakers, Joann Damron-Rodriguez, Janet C Frank, Birgit Pianosi, Jan S Jukema
This study explores whether there is a common core of competencies in European gerontology education programs by doing a cross-comparison of five undergraduate-level programs. Content analysis of competency profile documents at the five European educational programs were studied using thematic analysis. Study results document that there indeed is a common core of elements in gerontological educational programs. Three clusters which included a total of 15 categories were identified. The clusters were labeled professional attitude, communication skills, and service provision...
January 2017: Gerontology & Geriatrics Education
https://www.readbyqxmd.com/read/28222259/band-alignment-at-gan-single-layer-wse2-interface
#17
Malleswararao Tangi, Pawan Mishra, Chien-Chih Tseng, Tien Khee Ng, Mohamed Nejib Hedhili, Dalaver H Anjum, Mohd Sharizal Alias, Nini Wei, Lain-Jong Li, Boon S Ooi
We study the band discontinuity at the GaN/single-layer (SL) WSe2 heterointerface. The GaN thin layer is epitaxially grown by molecular beam epitaxy on chemically vapor deposited SL-WSe2/c-sapphire. We confirm that the WSe2 was formed as an SL from structural and optical analyses using atomic force microscopy, scanning transmission electron microscopy, micro-Raman, absorbance, and micro-photoluminescence spectra. The determination of band offset parameters at the GaN/SL-WSe2 heterojunction is obtained by high-resolution x-ray photoelectron spectroscopy, electron affinities and the electronic bandgap values of SL-WSe2 and GaN...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28222222/linear-immunoglobulin-a-dermatosis-mimicking-toxic-epidermal-necrolysis-a-case-report-of-etanercept-treatment
#18
M Prieto-Barrios, V Velasco-Tamariz, F Tous-Romero, S Burillo-Martinez, C Zarco-Olivo, J L Rodriguez-Peralto, P L Ortiz-Romero
A 65-year-old pluripathological woman attended our hospital with a cutaneous eruption of sudden appearance after vancomycin treatment. She presented targetoid lesions affecting approximately 25-30% of her body surface, large erosions, with mucosal lesions and positive Nikolsky sign. Under the initial clinical suspicion of Toxic Epidermal Necrolysis (TEN), and considering recent literature of its successful use in these cases, she was treated with a single dose of anti-Tumor Necrosis Factor (anti-TNF) agent etanercept...
February 21, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28222221/elastase-2-an-angiotensin-ii-generating-enzyme-contributes-to-increased-ang-ii-in-resistance-arteries-of-mice-with-myocardial-infarction
#19
Christiane Becari, Marcondes A B Silva, Marina T Durand, Cibele M Prado, Eduardo B Oliveira, Mauricio S Ribeiro, Helio C Salgado, Maria Cristina O Salgado, Rita C Tostes
Angiotensin II (Ang II), whose generation largely depends on angiotensin-converting enzyme activity, mediates most of the renin-angiotensin-system effects. Elastase-2 (ELA-2), a chymotrypsin-serine protease elastase family member 2A, alternatively generates Ang II in rat arteries. Myocardial infarction (MI) leads to intense RAS activation, but mechanisms involved on Ang II-generation in resistance arteries are unknown. We hypothesized that ELA-2 contributes to vascular Ang II generation and to cardiac damage in mice submitted to MI...
February 21, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28222219/longitudinal-follow-up-of-adult-survivors-of-ewing-sarcoma-a-report-from-the-childhood-cancer-survivor-study
#20
Neyssa M Marina, Qi Liu, Sarah S Donaldson, Charles A Sklar, Gregory T Armstrong, Kevin C Oeffinger, Wendy M Leisenring, Jill P Ginsberg, Tara O Henderson, Joseph P Neglia, Marilyn A Stovall, Yutaka Yasui, R Lor Randall, David S Geller, Leslie L Robison, Kirsten K Ness
BACKGROUND: Ewing sarcoma survivors (ESSs) are at increased risk for treatment-related complications. The incidence of treatment-related morbidity and late mortality with aging is unknown. METHODS: This study reports survival probabilities, estimated with the Kaplan-Meier method, and the cumulative incidence of cause-specific mortality and chronic conditions among ESSs in the Childhood Cancer Survivor Study who were treated between 1970 and 1986. Piecewise exponential models were used to estimate relative rates (RRs) and 95% confidence intervals (CIs) for these outcomes...
February 21, 2017: Cancer
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