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https://www.readbyqxmd.com/read/29055270/executive-functioning-concern-about-falling-and-quadriceps-strength-mediate-the-relationship-between-impaired-gait-adaptability-and-fall-risk-in-older-people
#1
Maria Joana D Caetano, Stephen R Lord, Matthew A Brodie, Daniel Schoene, Paulo H S Pelicioni, Daina L Sturnieks, Jasmine C Menant
BACKGROUND: Reduced ability to adapt gait, particularly under challenging conditions, may be an important reason why older adults have an increased risk of falling. This study aimed to identify cognitive, psychological and physical mediators of the relationship between impaired gait adaptability and fall risk in older adults. METHODS: Fifty healthy older adults (mean±SD: 74±7years) were categorised as high or low fall risk, based on past falls and their performance in the Physiological Profile Assessment...
October 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29055150/distinct-sources-of-gene-flow-produce-contrasting-population-genetic-dynamics-at-different-range-boundaries-of-a-choristoneura-budworm
#2
Gwylim S Blackburn, Bryan M T Brunet, Kevin Muirhead, Michel Cusson, Catherine Béliveau, Roger C Levesque, Lisa M Lumley, Felix A H Sperling
Populations are often exposed to multiple sources of gene flow, but accounts are lacking of the population genetic dynamics that result from these interactions or their effects on local evolution. Using a genomic clines framework applied to 1195 SNPs, we documented genome-wide, locus-specific patterns of introgression between Choristoneura occidentalis biennis spruce budworms and two ecologically divergent relatives, C. o. occidentalis and C. fumiferana, that it interacts with at alternate boundaries of its range...
October 21, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29055116/inhaled-cryptococcus-neoformans-elicits-allergic-airway-inflammation-independent-of-nf%C3%AE%C2%BAb-signaling-in-lung-epithelial-cells
#3
Andrew J McDermott, Tyler A Tumey, Mingwei Huang, Christina M Hull, Bruce S Klein
Pulmonary challenge with the ubiquitous fungus Cryptococcus neoformans results in allergic airway inflammation (AAI) characterized by robust recruitment of eosinophils and T-cells producing type 2 cytokines to the lungs. Previous studies have demonstrated a critical role for NFκB activation within lung epithelial cells (LECs) in driving AAI in response to protein allergens, yet the role of LEC-intrinsic NFκB in promoting AAI following exposure to C. neoformans is poorly understood. To investigate the role of LEC-intrinsic NFκB in promoting AAI following C...
October 20, 2017: Immunology
https://www.readbyqxmd.com/read/29055094/divergent-migration-within-lake-sturgeon-acipenser-fulvescens-populations-multiple-distinct-patterns-exist-across-an-unrestricted-migration-corridor
#4
S T Kessel, D W Hondorp, C M Holbrook, J C Boase, J A Chiotti, M V Thomas, T C Wills, E F Roseman, R Drouin, C C Krueger
1.Population structure, distribution, abundance, and dispersal arguably underpin the entire field of animal ecology, with consequences for regional species persistence, and provision of ecosystem services. Divergent migration behaviours among individuals or among populations is an important aspect of the ecology of highly-mobile animals, allowing populations to exploit spatially- or temporally-distributed food and space resources. 2.This study investigated the spatial ecology of lake sturgeon (Acipenser fulvescens) within the barrier free Huron-Erie Corridor (HEC), which connects Lake Huron and Lake Erie of the North American Laurentian Great Lakes...
October 21, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29055092/crown-initiative-and-preterm-birth-prevention-researchers-and-editors-commit-to-implement-core-outcome-sets
#5
J van 't Hooft, Z Alfirevic, E V Asztalos, J R Biggio, L Dugoff, M Hoffman, G Lee, B W Mol, R C Pacagnella, E Pajkrt, G R Saade, A H Shennan, C Vayssière, K S Khan
The emphasis on research quality has taken great strides in recent years. Publication of clinical trial protocols (i.e. SPIRIT guideline), prospective registration (e.g. ClinicalTrials. gov, WHO registry), high standards in research conduct (i.e. ICH-Good Clinical Practice guidelines) and transparent reporting of the findings (i.e. CONSORT guideline) are all becoming features of clinical effectiveness research. However, many more gains are possible to improve the efficiency of clinical research and therefore reduction of waste in health research, a problem that is estimated to consume 85% of the global medical research budget each year...
October 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29055001/listeria-monocytogenes-replicate-in-bone-marrow-derived-cd11c-cells-but-not-in-dendritic-cells-isolated-from-the-murine-gastrointestinal-tract
#6
Grant S Jones, Victoria C Smith, Sarah E F D'Orazio
Recent fate-mapping studies and gene-expression profiles suggest that commonly used protocols to generate bone marrow-derived cultured dendritic cells yield a heterogeneous mixture, including some CD11c(hi) cells that may not have a bona fide counterpart in vivo. In this study, we provide further evidence of the discordance between ex vivo-isolated and in vitro-cultured CD11c(+) cells by analyzing an additional phenotype, the ability to support cytosolic growth of the facultative intracellular bacterial pathogen Listeria monocytogenes Two days after foodborne infection of mice with GFP-expressing L...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29054991/the-influence-of-bone-mineral-density-and-cortical-index-on-the-complexity-of-fractures-of-the-proximal-humerus
#7
J W A M den Teuling, B S Pauwels, L Janssen, C E Wyers, H M J Janzing, J P W van den Bergh, J W Morrenhof
OBJECTIVES: The goal of this study is to investigate the relation between indicators of osteoporosis (i.e., bone mineral density (BMD), and Cortical Index (CI)) and the complexity of a fracture of the proximal humerus as a result of a low-energy trauma. METHODS: A retrospective chart review of 168 patients (mean age 67.2 years, range 51 to 88.7) with a fracture of the proximal humerus between 2007 and 2011, whose BMD was assessed at the Fracture Liaison Service with Dual Energy X-ray Absorptiometry (DXA) measurements of the hip, femoral neck (FN) and/or lumbar spine (LS), and whose CI and complexity of fracture were assessed on plain anteroposterior radiographs of the proximal humerus...
October 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/29054880/common-synaptic-input-to-motor-neurons-and-neural-drive-to-targeted-reinnervated-muscles
#8
D Farina, A M Castronovo, I Vujaklija, A Sturma, S Salminger, C Hofer, O C Aszmann
We compared the behaviour of motor neurons innervating their physiological muscle targets with motor neurons from the same spinal segment whose axons were surgically redirected to remnant muscles (targeted muscle reinnervation). The objective was to assess whether motor neurons with non-physiological innervation receive similar synaptic input and could be voluntary controlled as motor neurons with natural innervation. For this purpose, we acquired high-density EMG signals from the biceps brachii in 5 male trans-humeral amputees who underwent targeted reinnervation of this muscle by the ulnar nerve and from the first dorsal interosseous muscle of 5 healthy individuals to investigate the natural innervation of the ulnar nerve...
October 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29054874/extracellular-polymeric-matrix-production-and-relaxation-under-fluid-shear-and-mechanical-pressure-in-staphylococcus-aureus-biofilms
#9
Jiapeng Hou, Deepak H Veeregowda, Betsy van de Belt-Gritter, Henk J Busscher, Henny C van der Mei
The viscoelasticity of a biofilm's EPS (extracellular-polymeric-substance) matrix conveys protection against mechanical challenges, but adaptive responses of biofilm inhabitants to produce EPS are not well known. Here, we compare the response of a biofilm of an EPS producing (ATCC 12600) and non-EPS producing (5298) Staphylococcus aureus strain to fluid shear and mechanical challenge. Confocal-Laser-Scanning-Microscopy confirmed absence of calcofluorwhite-stainable EPS in biofilms of S. aureus 5298. ATR-FTIR spectroscopy combined with tribometry indicated that the polysaccharide production per bacterium in the initial adhering layer was higher during growth at high shear than at low shear and this increased EPS production extended to entire biofilms, as indicated by tribometrically measured coefficients of friction (CoF)...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054840/contemporary-risk-stratification-after-myocardial-infarction-in-the-community-performance-of-scores-and-incremental-value-of-soluble-suppression-of-tumorigenicity-2
#10
Yariv Gerber, Susan A Weston, Maurice Enriquez-Sarano, Allan S Jaffe, Sheila M Manemann, Ruoxiang Jiang, Véronique L Roger
BACKGROUND: Current American Heart Association/American College of Cardiology guidelines recommend the GRACE (Global Registry of Acute Coronary Events) and TIMI (Thrombolysis in Myocardial Infarction) scores to assess myocardial infarction (MI) prognosis. Changes in the epidemiological characteristics of MI and the availability of new biomarkers warrant an assessment of the performance of these scores in contemporary practice. We assessed the following: (1) the performance of GRACE and TIMI to predict 1-year mortality in a cohort of patients stratified by ST-segment elevation MI (STEMI) and non-STEMI (NSTEMI) and (2) the incremental discriminatory power of soluble suppression of tumorigenicity-2, a myocardial fibrosis biomarker...
October 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29054815/whole-brain-radiotherapy-or-autologous-stem-cell-transplantation-as-consolidation-strategies-after-high-dose-methotrexate-based-chemoimmunotherapy-in-patients-with-primary-cns-lymphoma-results-of-the-second-randomisation-of-the-international-extranodal-lymphoma
#11
Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Christopher P Fox, Elisabeth Schorb, Paul La Rosée, Mascha Binder, Alberto Fabbri, Valter Torri, Eleonora Minacapelli, Monica Falautano, Fiorella Ilariucci, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Peter Johnson, Kim M Linton, Tobias Pukrop, Jette Sønderskov Gørløv, Monica Balzarotti, Georg Hess, Ulrich Keller, Stephan Stilgenbauer, Jens Panse, Alessandra Tucci, Lorella Orsucci, Francesco Pisani, Alessandro Levis, Stefan W Krause, Hans J Schmoll, Bernd Hertenstein, Mathias Rummel, Jeffery Smith, Michael Pfreundschuh, Giuseppina Cabras, Francesco Angrilli, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Jürgen Finke, Michele Reni, Franco Cavalli, Emanuele Zucca, Gerald Illerhaus
BACKGROUND: The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested...
October 17, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29054749/men-with-unilateral-achilles-tendinopathy-have-impaired-balance-on-the-symptomatic-side
#12
M Scholes, S Stadler, D Connell, C Barton, R A Clarke, A L Bryant, P Malliaras
OBJECTIVES: To investigate single leg standing balance in males with mid-portion Achilles tendinopathy (AT). DESIGN: Cross sectional case study. METHODS: Centre of pressure (COP) path length was measured using a Wii Balance Board (WBB) in 21 male participants (20-60 years) with unilateral mid-portion AT during single-limb standing on each limb with eyes open and closed. Ultrasound imaging of both Achilles tendons was also performed by one blinded assessor, and the anteroposterior (AP) thickness and presence of pathology was determined...
October 6, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29054747/u-s-army-physical-demands-study-identification-and-validation-of-the-physically-demanding-tasks-of-combat-arms-occupations
#13
Marilyn A Sharp, Bruce S Cohen, Michael W Boye, Stephen A Foulis, Jan E Redmond, Kathleen Larcom, Jay R Hydren, Deborah L Gebhardt, Maria C Canino, Bradley J Warr, Edward J Zambraski
OBJECTIVES: In 2013, the U.S. Army began developing physical tests to predict a recruit's ability to perform the critical, physically demanding tasks (CPDTs) of combat arms jobs previously not open to women. The purpose of this paper is to describe the methodology and results of analyses of the accuracy and inclusiveness of the critical physically demanding task list. While the job analysis included seven combat arms jobs, only data from the 19D Cavalry Scout occupation are presented as the process was similar for all seven jobs...
October 5, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29054689/breast-cancer-survivorship-care-variations-between-adjuvant-chemotherapy-regimens
#14
Alexis D Leal, Holly Van Houten, Lindsey Sangaralingham, Rachel A Freedman, Ahmedin Jemal, Heather B Neuman, Tufia C Haddad, Robert W Mutter, Theresa H M Keegan, Sarah S Mougalian, Charles L Loprinzi, Cary P Gross, Nilay Shah, Kathryn J Ruddy
BACKGROUND: Treatment-related toxicity can vary substantially between chemotherapy regimens. In this study we evaluated the frequency of outpatient office visits among a cohort of early stage breast cancer survivors after completion of 4 different adjuvant chemotherapy regimens to better understand how differences in toxicities between regimens might affect health care use. MATERIALS AND METHODS: We analyzed administrative claims data from a US commercial insurance database (OptumLabs) to identify women who received adjuvant doxorubicin/cyclophosphamide (AC), AC followed or preceded by docetaxel or paclitaxel (AC-T), AC concurrent with docetaxel or paclitaxel (TAC), or docetaxel/cyclophosphamide (TC) between 2008 and 2014...
September 22, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29054688/collagenous-matrix-supported-by-a-3d-printed-scaffold-for-osteogenic-differentiation-of-dental-pulp-cells
#15
Farahnaz Fahimipour, Erfan Dashtimoghadam, Morteza Rasoulianboroujeni, Mostafa Yazdimamaghani, Kimia Khoshroo, Mohammadreza Tahriri, Amir Yadegari, Jose A Gonzalez, Daryoosh Vashaee, Douglas C Lobner, Tahereh S Jafarzadeh Kashi, Lobat Tayebi
OBJECTIVE: A systematic characterization of hybrid scaffolds, fabricated based on combinatorial additive manufacturing technique and freeze-drying method, is presented as a new platform for osteoblastic differentiation of dental pulp cells (DPCs). METHODS: The scaffolds were consisted of a collagenous matrix embedded in a 3D-printed beta-tricalcium phosphate (β-TCP) as the mineral phase. The developed construct design was intended to achieve mechanical robustness owing to 3D-printed β-TCP scaffold, and biologically active 3D cell culture matrix pertaining to the Collagen extracellular matrix...
October 17, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29054663/characterization-of-bacterial-diversity-in-contaminated-groundwater-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#16
Misty S Martin, Inês C Santos, Doug D Carlton, Paula Stigler-Granados, Zacariah L Hildenbrand, Kevin A Schug
Groundwater is a major source for drinking water in the United States, and therefore, its quality and quantity is of extreme importance. One major concern that has emerged is the possible contamination of groundwater due to the unconventional oil and gas extraction activities. As such, the impacts of exogenous contaminants on microbial ecology is an area to be explored to understand what are the chemical and physical conditions that allow the proliferation of pathogenic bacteria and to find alternatives for water treatment by identifying organic-degrading bacteria...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054661/coordinated-role-of-soluble-and-cell-wall-bound-phenols-is-a-key-feature-of-the-metabolic-adjustment-in-a-mining-woody-fleabane-dittrichia-viscosa-l-population-under-semi-arid-conditions
#17
Antonio López-Orenes, María C Bueso, Isabel M Párraga-Aguado, Antonio A Calderón, María A Ferrer
Environmental contamination by hazardous heavy metals/metalloids (metal(loid)s) is growing worldwide. To restrict the migration of toxic contaminants, the establishment of a self-sustainable plant cover is required. Plant growth in multi-polluted soils is a challenging issue not only by metal(loid) toxicities, but also by the co-occurrence of other stressors. Dittrichia viscosa is a pioneer Mediterranean species able to thrive in metal(loid)-enriched tailings in semi-arid areas. The aim of the present work was to examine the metabolic adjustments involved in the acclimation responses of this plant to conditions prevailing in mine-tailings during Mediterranean spring and summer...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054611/maternal-undernutrition-during-lactation-alters-nicotine-reward-and-dopac-dopamine-ratio-in-cerebral-cortex-in-adolescent-mice-but-does-not-affect-nicotine-induced-nachrs-upregulation
#18
Ana C Dutra-Tavares, Juliana O Silva, André L Nunes-Freitas, Vinícius M S Guimarães, Ulisses C Araújo, Ellen P S Conceição, Egberto G Moura, Patrícia C Lisboa, Cláudio C Filgueiras, Alex C Manhães, Yael Abreu-Villaça, Anderson Ribeiro-Carvalho
Early undernutrition causes long lasting alterations that affect the response to psychoactive drugs. Particularly, undernutrition during lactation affects the acute locomotor response to nicotine during adolescence, but the reward effect of continued exposure to nicotine remains unknown. The goal of this study was to investigate the effects of undernutrition during lactation on the nicotine susceptibility indexed via conditioned place preference (CPP), on dopamine content and turnover and on nicotine-induced nicotinic cholinergic receptor (nAChR) upregulation in the cerebral cortex, midbrain and hippocampus of adolescent mice...
October 17, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29054600/microbe-dependent-induction-of-il-9-by-cla-t-cells-in-psoriasis-and-relationship-with-il-17a
#19
Ester Ruiz-Romeu, Marta Ferran, Carmen de Jesús-Gil, Pablo García, Marc Sagristà, J M Casanova, J M Fernández, Anca Chiriac, Péter Hóllo, Antonio Celada, Ramon M Pujol, Luis F Santamaria-Babí
IL-9 is present in psoriatic lesions and produced by lymphocytes. However, it is not known whether this cytokine is induced by relevant pathogenic triggers of psoriasis, such as Streptococcus pyogenes. Here we addressed the production of IL-9 in response to various pathogens in a psoriatic ex vivo model. Extracts of S. pyogenes and C. albicans triggered the production of IL-9 and also IL-17A and IFN-γ. This induction was dependent on the interaction between CLA(+) T-cells and epidermal cells. Neutralization of IL-9 reduced S...
October 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29054595/the-n-acylethanolamine-acid-amidase-inhibitor-arn077-suppresses-inflammation-and-pruritus-in-a-mouse-model-of-allergic-dermatitis
#20
O Sasso, M Summa, A Armirotti, S Pontis, C De Mei, D Piomelli
N-acylethanolamine acid amidase (NAAA), a cysteine hydrolase highly expressed in macrophages and B-lymphocytes, catalyzes the degradation of palmitoylethanolamide (PEA). PEA is an agonist of peroxisome proliferator-activated receptor-α (PPAR-α) and an important regulator of pain and innate immunity. In the present study, we investigated the properties of the NAAA inhibitor, ARN077, in a mouse model of allergic contact dermatitis. Acute topical applications of ARN077 attenuated key signs of DNFB-induced dermatitis in a dose-dependent manner...
October 17, 2017: Journal of Investigative Dermatology
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