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https://www.readbyqxmd.com/read/29668124/a-reduced-dose-of-fluconazole-as-primary-antifungal-prophylaxis-is-not-associated-with-increased-risk-of-invasive-fungal-infections-after-allogeneic-stem-cell-transplantation-from-a-hla-identical-sibling
#1
B Sarina, J Mariotti, S Bramanti, L Morabito, R Crocchiolo, A Rimondo, F Tordato, D Pocaterra, E Casari, Chiara De Philippis, C Carlo-Stella, A Santoro, L Castagna
BACKGROUND: Invasive fungal infections (IFI) represent a common side effect of allogeneic hematopoietic stem cell transplant (allo-SCT), resulting in increased non relapse mortality (NRM) and reduced overall survival (OS) rates. 75-days of Fluconazole 400 mg/day represents the standard primary antifungal prophylaxis (PAP) after allo-SCT, especially for low-risk transplants. However, the ideal dosage of fluconazole has never been tested. METHODS: Here we report the experience of our institution on 113 consecutive patients receiving an allo-SCT from a HLA identical sibling between 1999 and 2015, where PAP consisted of fluconazole 100 mg/day only during the pre-engraftment phase...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#2
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668119/n-heterocyclic-carbene-analogues-of-thiele-and-chichibabin-hydrocarbons
#3
Dennis Rottschäfer, Nga Kim T Ho, Beate Neumann, Hans-Georg Stammler, Maurice van Gastel, Diego M Andrada, Rajendra S Ghadwal
Stable N-heterocyclic carbene analogues of Thiele and Chichibabin hydrocarbons, [(IPr)(C6 H4 )(IPr)] and [(IPr)(C6 H4 )2 (IPr)] (4 and 5, respectively; IPr=C{N(2,6-iPr2 C6 H3 )}2 CHCH), are reported. In a nickel-catalyzed double carbenylation of 1,4-Br2 C6 H4 and 4,4'-Br2 (C6 H4 )2 with IPr (1), [(IPr)(C6 H4 )(IPr)](Br)2 (2) and [(IPr)(C6 H4 )2 (IPr)](Br)2 (3) were generated, which respectively afforded 4 and 5 as crystalline solids upon reduction with KC8 . Experimental and computational studies support the semiquinoidal nature of 5 with a small singlet-triplet energy gap ΔES-T of 10...
April 18, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29668108/sonographic-assessment-of-swallowing-in-irradiated-nasopharyngeal-carcinoma-patients
#4
Dennis T H Cheng, Kathy Y S Lee, Anil T Ahuja, Michael C F Tong
OBJECTIVES/HYPOTHESIS: Ultrasonography is an emerging clinical tool to study the dysfunction of swallowing muscles. This was the first sonographic study to assess the relationship between suprahyoid muscle contraction, hyoid bone displacement, and penetration-aspiration status (PAS) during swallowing in nasopharyngeal carcinoma (NPC) patients treated with radiotherapy (RT). The study also aimed to establish reliability data for the sonographic technique described. STUDY DESIGN: Cross-sectional study...
April 18, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29668078/adherence-and-immune-response-to-revaccination-following-hematopoietic-stem-cell-transplantation-at-a-pediatric-onco-hematology-reference-center
#5
Fernanda Gouveia-Alves, Roseane Gouveia, Valéria C Ginani, Adriana Seber, Danielle A Kuramoto, Gabriel F A Murad, Fernanda G Spina, Antonio S Petrilli, Victor G Zecchin, Celso Granato, Fabianne Carlesse, M Isabel de Moraes-Pinto
BACKGROUND: Revaccination after hematopoietic stem cell transplantation (HSCT) is necessary to compensate for the loss of immunological memory. The aims of this study were to evaluate the adherence to revaccination schedule and the humoral immune response to different vaccine antigens in HSCT pediatric and young adult patients. METHODS: Patients submitted to HSCT for over 3 years were recruited. After written informed consent, a questionnaire was filled in, the vaccination card was analyzed, a blood sample was collected and tested by ELISA for diphtheria, Haemophilus influenzae type b (Hib), hepatitis A, hepatitis B, tetanus, measles, rubella and varicella antibodies...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29668030/uv-c-irradiation-on-the-quality-of-green-tea-effect-on-catechins-antioxidant-activity-and-cytotoxicity
#6
Matthew J Vergne, Ankit Patras, Manreet S Bhullar, Lincoln M Shade, Michael Sasges, Kanyasiri Rakariyatham, Che Pan, Hang Xiao
Short-wavelength ultraviolet (UV-C) irradiation is a nonthermal processing technique that is a possible alternative to the heat-pasteurization of tea beverages. This study investigated the effect of UV-C irradiation on the polyphenolic and total phenolic contents of a green tea beverage and analyzed cytotoxicity of irradiated green tea using a novel continuous flow-through UV system. UV-C fluence levels ranging from 0 to 240 mJ/cm2 were delivered to green tea, and polyphenols were chemically profiled. Continuous-flow UV-C irradiation of the green tea beverage at a fluence of 68 mJ/cm2  induced a minor reduction in the concentration of the most abundant catechin in green tea, (-)-epigallocatechin gallate (EGCG), from 145 to 131...
April 18, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29667858/longitudinal-analysis-of-varicella-zoster-virus-specific-antibodies-in-systemic-lupus-erythematosus-no-association-with-subclinical-viral-reactivations-or-lupus-disease-activity
#7
C Rondaan, C C van Leer, S van Assen, H Bootsma, K de Leeuw, S Arends, N A Bos, J Westra
Systemic lupus erythematosus (SLE) patients are at high risk of herpes zoster. Previously, we found increased immunoglobulin (Ig)G levels against varicella-zoster virus (VZV) in SLE patients compared to controls, while antibody levels against diphtheria and cellular immunity to VZV were decreased. We aimed to test our hypothesis that increased VZV-IgG levels in SLE result from subclinical VZV reactivations, caused by stress because of lupus disease activity or immunosuppressive drug use. Methods Antibody levels to VZV (IgG, IgA, IgM), total IgG and VZV-DNA were longitudinally determined in the serum of 34 SLE patients, using enzyme-linked immunosorbent assay and polymerase chain reaction...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29667842/the-role-of-pcsk9-inhibitors-in-the-treatment-of-hypercholesterolemia
#8
Roshni S Patel, Emily M Scopelliti, Oludamilola Olugbile
OBJECTIVE: To evaluate the efficacy, safety, and cost-effectiveness of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors and describe its place in therapy for the treatment of hypercholesterolemia. DATA SOURCES: A search of MEDLINE, CINAHL, and Clinicaltrials.gov was performed from January 2012 to March 2018 to identify literature pertaining to PCSK9 inhibitors using pre-specified search terms. Additional references were identified from citations of the literature...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29667824/one-and-two-carbon-homologation-of-primary-and-secondary-alcohols-to-corresponding-carboxylic-esters-using-%C3%AE-carbonyl-bt-sulfones-as-common-intermediate
#9
David J-Y D Bon, Ondřej Kováč, Vendula Ferugová, František Zálešák, Jiri Pospisil
Herein we report the efficient one- and two-carbon homologation of 1° and 2° alcohols to their corresponding homologated esters via the Mitsunobu reaction using β-carbonyl benzothiazole (BT) sulfone intermediates. The one-carbon homologation approach uses standard Mitsunobu C-S bond formation, oxidation and subsequent alkylation, while the two-carbon homologation uses a less common C-C bond forming Mitsunobu reaction. In this latter case, the use of β-BT sulfone bearing esters lowers the pKa sufficiently enough for the substrate to be used as a carbon-based nucleophile and deliver the homologated β-BT sulfone ester, this superfluous sulfone group can then be cleaved...
April 18, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29667816/nitrate-photochemistry-at-the-air-ice-interface-and-in-other-ice-reservoirs
#10
Alexander S McFall, Kasey C Edwards, Cort Anastasio
The photolysis of snowpack nitrate (NO3-) is an important source of gaseous reactive nitrogen species that affect atmospheric oxidants, particularly in remote regions. However, it is unclear whether nitrate photochemistry differs between the three solute reservoirs in/on ice: in liquid-like regions (LLRs) in the ice; within the solid ice matrix; and in a quasi-liquid layer (QLL) at the air-ice interface, where past work indicates photolysis is enhanced. In this work, we explore the photoformation of nitrite in these reservoirs using laboratory ices...
April 18, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29667773/benzyl-isothiocyanate-attenuates-the-hydrogen-peroxide-induced-interleukin-13-expression-through-glutathione-s-transferase-p-induction-in-t-lymphocytic-leukemia-cells
#11
Yue Tang, Sho Naito, Naomi Abe-Kanoh, Seiji Ogawa, Shu Yamaguchi, Beiwei Zhu, Yoshiyuki Murata, Yoshimasa Nakamura
We investigated the effect of benzyl isothiocyanate (BITC) on the hydrogen peroxide-induced gene expression of a T-helper-2 cytokine, interleukin (IL)-13, in T lymphocytic leukemia Jurkat cells. The 24-h pretreatment of BITC significantly inhibited the IL-13 expression enhanced by hydrogen peroxide. Although the BITC pretreatment did not change the enhanced level of the phosphorylated c-Jun N-terminal kinase (JNK), it significantly inhibited the nuclear translocation of c-Jun induced by hydrogen peroxide. BITC also increased the protein expression of glutathione S-transferase (GST) isozymes, GSTP1/2, as well as the total GST activity...
April 18, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29667663/spontaneous-formation-of-a-chiral-mo-2-o-2-s-2-2-based-cluster-driven-by-dimeric-te-2-o-6-based-templates
#12
Jamie W Purcell, De-Liang Long, Edward C Lee, Leroy Cronin, Haralampos N Miras
Utilization of [Mo2S2O2(H2O)6]2+ and a tellurite anion led to the formation of three new clusters, 1-3, with unique structural features. The tellurite anion not only templated the formation of [(Mo2O2S2)4(TeO3)(OH)9]3- 1 and [(Mo2O2S2)12(TeO3)4(TeO4)2 (OH)18]10- 3, but also the in situ generation of two different types of dimeric {Te2O6} based moieties induced the spontaneous assembly of the chiral [(Mo2O2S2)10(TeO3)(Te2O6)2(OH)18]8- anionic cluster, 2.
April 18, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29667604/universal-doping-evolution-of-the-superconducting-gap-anisotropy-in-single-crystals-of-electron-doped-ba-fe-sub-1-x-sub-rh-sub-x-sub-sub-2-sub-as-sub-2-sub-from-london-penetration-depth-measurements
#13
Hyunsoo Kim, Makariy A Tanatar, Catalin Martin, Erick C Blomberg, Ni Ni, Sergey L Bud'ko, Paul C Canfield, Ruslan Prozorov
Doping evolution of the superconducting gap anisotropy was studied in single crystals of 4$d$-electron doped Ba(Fe$_{1-x}$Rh$_x$)$_2$As$_2$ using tunnel diode resonator measurements of the temperature variation of London penetration depth $\Delta\lambda(T)$. Single crystals with doping level representative of underdoped regime $x$ = 0.039 ($T_c=$ 15.5 K), close to optimal doping $x=$ 0.057 ($T_c=$ 24.4 K) and overdoped $x=$ 0.079 ($T_c=$ 21.5 K) and $x=$ 0.131($T_c=$ 4.9 K) were studied. Superconducting energy gap anisotropy was characterized by the exponent, $n$, by fitting the data to the power-law, $\Delta\lambda=AT^n$...
April 18, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29667580/severe-asthma-phenotypes-classified-by-site-of-airway-involvement-and-remodeling-via-chest-ct-scan
#14
S Kim, K Nam Jin, S H Cho, C Hyun Lee, H R Kang
BACKGROUND AND OBJECTIVE: This study aimed to establish a system that can classify severe asthma on the basis of airway remodeling patterns visualized by computed tomography (CT) images and to evaluate the clinical characteristics of individual image-based subtypes. METHODS: Chest CT images of severe asthma patients were retrospectively evaluated to classify phenotypes by site of airway involvement and remodeling. The association between radiologic subtypes and clinical characteristics was assessed...
April 18, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29667575/a-cluster-of-two-human-cases-of-tick-borne-encephalitis-tbe-transmitted-by-unpasteurised-goat-milk-and-cheese-in-germany-may-2016
#15
S O Brockmann, R Oehme, T Buckenmaier, M Beer, A Jeffery-Smith, M Spannenkrebs, S Haag-Milz, C Wagner-Wiening, C Schlegel, J Fritz, S Zange, M Bestehorn, A Lindau, D Hoffmann, S Tiberi, U Mackenstedt, G Dobler
In May 2016, two cases of tick-borne encephalitis (TBE) were confirmed by serology (positive IgM and IgG antibodies against TBE virus (TBEV) in serum), with a possible link to raw milk and cheese from a goat farm in a region in Baden-Württemberg, Germany not previously known as TBE-endemic. The outbreak investigation identified 32 consumers of goat dairy products (29 consumers, one farm employee, two owners) of whom none had IgM antibodies against TBEV 3-8 weeks after consumption. Of the 27 notified TBE cases in the State, none reported consumption of raw goat milk or cheese from the suspected farm...
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29667555/synthesis-cytotoxicity-and-antioxidant-activity-of-new-analogues-of-rc-121-synthetic-derivatives-of-somatostatin
#16
Diana Wesselinova, Emilia D Naydenova, S Staykova, I G Goshev, L Vezenkov
BACKGROUND: Based on the structure of RC-121 (D-Phe-c (Cys-Tyr-D-Trp-Lys-Val-Cys)-Thr-NH2, - synthetic derivatives of somatostatin), some analogs were synthesized and tested for in vitro cytotoxic and antioxidant activity. OBJECTIVES: The new analogs were modifyed at position 5 with Dap (diaminopropanoic acid), Dab (diaminobutanoic acid) and Orn and at position 6 with the unnatural amino acids Tle (t-leucine). METHODS: The in vitro cytotoxic effects of the substances were investigated against a panel of human tumor cell lines HT-29 (human colorectal cancer cell line), MDA-MB-23 (human breast cancer cell line), Hep G-2 (human hepatocellular carcinoma cell line) and HeLa (cervical cancer cell line)...
April 17, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29667534/assessing-manual-wheelchair-caster-design-for-mobility-in-winter-conditions
#17
M Berthelette, D D Mann, J Ripat, C M Glazebrook
Wheelchair users who live in cold climates are faced with daily difficulties related to personal independence and societal inclusion, as their assistive devices are unable to overcome the physical barriers created by snow and ice. The purpose of the research was to evaluate four commercially available casters to determine which caster performed best on snow-covered surfaces. Performance measures included: travel time, force transfer through the palms of the hands, number of propulsive movements, static resistance to movement, kinetic resistance to movement, and caster penetration into the packed snow...
April 18, 2018: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/29667520/preparation-and-properties-of-cryogel-based-on-poly-hydroxypropyl-methacrylate
#18
Mengfan Zhai, Feng Ma, Junying Li, Binbin Wan, Ning Yu
A novel supermacroporous poly(hydroxypropyl methacrylate) (p(HPMA)) cryogel was synthesized by cryogelation method at -16 °C. In this synthesis process, HPMA was used as a monomer, and N,N'-methylenebisacrylamide (MBAAm) was used as cross-linker; the reaction was carried out in the presence of redox initiator pair N,N,N',N'-tetramethylene diamine (TEMED) and ammonium persulfate (APS). The effect of monomer concentration, cross-linker content, cooling rate, and dioxane co-solvent were determined with respect to the pore structure, mechanical behavior, swelling degree, and porosity of cryogel...
April 18, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29667487/pre-colonization-with-the-commensal-fungus-candida-albicans-reduces-murine-susceptibility-to-clostridium-difficile-infection
#19
Laura Markey, Lamyaa Shaban, Erin R Green, Katherine P Lemon, Joan Mecsas, Carol A Kumamoto
Clostridium difficile is a major nosocomial pathogen responsible for close to half a million infections and 27,000 deaths annually in the U.S. Preceding antibiotic treatment is a major risk factor for C. difficile infection (CDI) leading to recognition that commensal microbes play a key role in resistance to CDI. Current antibiotic treatment of CDI is only partially successful due to a high rate of relapse. As a result, there is interest in understanding the effects of microbes on CDI susceptibility to support treatment of patients with probiotic microbes or entire microbial communities (e...
April 18, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29667396/direct-printing-of-graphene-electrodes-for-high-performance-organic-inverters
#20
Aditi Naik, Jae Joon Kim, Özlem Usluer, D Leonardo Gonzalez Arellano, Ethan B Secor, Antonio Facchetti, Mark C Hersam, Alejandro L Briseno, James J Watkins
The scalable fabrication of high-resolution electrodes and interconnects is necessary to enable advanced, high-performance, printed and flexible electronics. Here, we demonstrate the direct printing of graphene patterns with feature widths from 300 µm to ~310 nm by liquid-bridge-mediated nanotransfer molding. This solution-based technique enables residue-free printing of graphene patterns on a variety of substrates with surface energies between ~43 and 73 mN m-1 . Using printed graphene source and drain electrodes, high-performance organic field-effect transistors (OFETs) are fabricated with single-crystal rubrene (p-type) and fluorocarbon-substituted dicyanoperylene-3,4:9,10-bis(dicarboximide) (PDIF-CN2 ) (n-type) semiconductors...
April 18, 2018: ACS Applied Materials & Interfaces
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