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https://www.readbyqxmd.com/read/29143887/diagnosis-and-treatment-of-aplastic-anemia
#1
REVIEW
Scott A Peslak, Timothy Olson, Daria V Babushok
Acquired aplastic anemia (AA) is a rare, life-threatening bone marrow failure (BMF) disorder that affects patients of all ages and is caused by lymphocyte destruction of early hematopoietic cells. Diagnosis of AA requires a comprehensive approach with prompt evaluation for inherited and secondary causes of bone marrow aplasia, while providing aggressive supportive care. The choice of frontline therapy is determined by a number of factors including AA severity, age of the patient, donor availability, and access to optimal therapies...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143502/-exercise-induced-bronchoconstriction-epidemiology-physiopathology-and-management
#2
Fabienne Reinhard-Groebli, Laurent P Nicod
Exercise-induced bronchoconstriction, associated or not with asthma, describes a transient limitation of airflow in the airways occurring during or after physical activity, regardless of age or training. Bronchoconstriction on exertion is principally induced by thermal and fluid losses of the bronchial mucosa by hyperventilation of large air volumes. Respiratory symptoms are variable and not specific. Among bronchial provocation test, eucapnic voluntary hyperventilation owns the best sensitivity and specificity in the diagnosis of exercise-induced bronchoconstriction...
November 15, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29141215/octopamine-drives-endurance-exercise-adaptations-in-drosophila
#3
Alyson Sujkowski, Divya Ramesh, Axel Brockmann, Robert Wessells
Endurance exercise is an effective therapeutic intervention with substantial pro-healthspan effects. Male Drosophila respond to a ramped daily program of exercise by inducing conserved physiological responses similar to those seen in mice and humans. Female flies respond to an exercise stimulus but do not experience the adaptive training response seen in males. Here, we use female flies as a model to demonstrate that differences in exercise response are mediated by differences in neuronal activity. The activity of octopaminergic neurons is specifically required to induce the conserved cellular and physiological changes seen following endurance training...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29138049/pain-neurophysiology-education-and-therapeutic-exercise-for-patients-with-chronic-low-back-pain-a-single-blind-randomized-controlled-trial
#4
Bodes Pardo Gema, Lluch Girbés Enrique, Roussel Nathalie A, Gallego Izquierdo Tomás, Jiménez Penick Virginia, Pecos Martín Daniel
AIM: To assess the effect of a pain neurophysiology education program plus therapeutic exercise for patients with chronic low back pain (CLBP). DESIGN: Single-blind randomized controlled trial. SETTING: Private clinic (Clínica Bonn) and Alcalá de Henares University, Madrid, Spain. PARTICIPANTS: 56 patients with CLBP for 6 months or more. INTERVENTION: Participants were randomized to receive either a therapeutic exercise (TE) program consisting of motor control, stretching, and aerobic exercises (TE group, n=28) or the same therapeutic exercise program in addition to a pain neurophysiology education program (PNE+TE group, n=28), conducted in two 30 to 50 minute sessions in groups of 4 to 6 participants...
November 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29135458/immediate-effects-of-osteopathic-treatment-versus-therapeutic-exercise-on-patients-with-chronic-cervical-pain
#5
Xabier Galindez-Ibarbengoetxea, Igor Setuain Chourraut, Robinson Ramírez-Velez, Lars L Andersen, Miriam González-Izal, Andoni Jauregi Crespo, Mikel Izquierdo Crespo
Context • Alternatives to medication for immediate pain relief are needed because long-term use of pain medication has been associated with adverse effects. High-velocity, low-amplitude (HVLA) manipulation techniques (MTs) and craniocervical flexion (CCF) exercises have been frequently used in the management of chronic cervical pain. Objective • The study intended to compare the immediate effects on pain of a treatment using HVLA manipulation versus one using a CCF exercise protocol. Design • The research team designed a single-blinded, randomized clinical trial...
November 14, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/29132327/explaining-variance-in-self-directed-learning-readiness-of-first-year-students-in-health-professional-programs
#6
Craig E Slater, Anne Cusick, Jimmy C Y Louie
BACKGROUND: Self-directed learning (SDL) is expected of health science graduates; it is thus a learning outcome in many pre-certification programs. Previous research identified age, gender, discipline and prior education as associated with variations in students' self-directed learning readiness (SDLR). Studies in other fields also propose personality as influential. METHOD: This study investigated relationships between SDLR and age, gender, discipline, previous education, and personality traits...
November 13, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29131007/proteinase-activated-receptor-2-sensitivity-of-amplified-trpa1-activity-in-skeletal-muscle-afferent-nerves-and-exercise-pressor-reflex-in-rats-with-femoral-artery-occlusion
#7
Jihong Xing, Jianhua Li
BACKGROUND/AIMS: Limb ischemia occurs in peripheral artery disease (PAD). Sympathetic nerve activity (SNA) that regulates blood flow directed to the ischemic limb is exaggerated during exercise in this disease, and transient receptor potential channel A1 (TRPA1) in thin-fiber muscle afferents contributes to the amplified sympathetic response. The purpose of the present study was to determine the role of proteinase-activated receptor-2 (PAR2) in regulating abnormal TRPA1 function and the TRPA1-mediated sympathetic component of the exercise pressor reflex...
November 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130633/the-mitochondrial-metabolic-reprogramming-agent-trimetazidine-as-an-exercise-mimetic-in-cachectic-c26-bearing-mice
#8
Francesca Molinari, Fabrizio Pin, Stefania Gorini, Sergio Chiandotto, Laura Pontecorvo, Fabio Penna, Emanuele Rizzuto, Simona Pisu, Antonio Musarò, Paola Costelli, Giuseppe Rosano, Elisabetta Ferraro
BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function. Some drugs are able to reprogram cell metabolism and, in some cases, to enhance metabolic efficiency. Based on these premises, we chose to investigate the ability of the metabolic modulator trimetazidine (TMZ) to counteract skeletal muscle dysfunctions and wasting occurring in cancer cachexia...
November 11, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29128055/current-treatment-of-nonalcoholic-fatty-liver-disease-nonalcoholic-steatohepatitis
#9
REVIEW
Chun Kit Hung, Henry C Bodenheimer
Treatment of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is focused on patients with NASH because they are at highest risk for progressive liver disease. Current first-line treatment consists of lifestyle modifications. Patients should lose at least 7% to 10% of body weight via a combination of physical exercise and calorie restriction dieting. Surgical or endoscopic surgery for weight loss can be considered in obese patients, depending on degree of excess body weight and comorbidities...
February 2018: Clinics in Liver Disease
https://www.readbyqxmd.com/read/29127518/identifying-molecular-mediators-of-environmentally-enhanced-neurogenesis
#10
REVIEW
Brian E Eisinger, Xinyu Zhao
Adult hippocampal neurogenesis occurs throughout life and supports healthy brain functions. The production of new neurons decreases with age, and deficiencies in adult neurogenesis are associated with neurodevelopmental and degenerative disease. The rate of neurogenesis is dynamically sensitive to an individual's environmental conditions and experiences, and certain stimuli are known robustly to enhance neurogenesis in rodent models, including voluntary exercise, enriched environment, and electroconvulsive shock...
November 10, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29125009/exercise-beliefs-and-behaviours-of-individuals-with-joint-hypermobility-syndrome-ehlers-danlos-syndrome-hypermobility-type
#11
Jane V Simmonds, Anthony Herbland, Alan Hakim, Nelly Ninis, William Lever, Qasim Aziz, Mindy Cairns
PURPOSE: To explore exercise beliefs and behaviours of individuals with Joint Hypermobility syndrome/Ehlers-Danlos syndrome - hypermobility type and to explore patient experiences of physiotherapy. METHODS: A cross sectional questionnaire survey design was used to collect quantitative and qualitative data from adult members of the Hypermobility Syndromes Association and Ehlers-Danlos Syndrome Support UK. Descriptive and inferential statistics were used to analyse the data...
November 10, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29121940/plasma-irisin-is-elevated-in-type-2-diabetes-and-is-associated-with-increased-e-selectin-levels
#12
Karan S Rana, Chathyan Pararasa, Islam Afzal, David A Nagel, Eric J Hill, Clifford J Bailey, Helen R Griffiths, Ioannis Kyrou, Harpal S Randeva, Srikanth Bellary, James E Brown
BACKGROUND: Irisin is a hormone released mainly from skeletal muscle after exercise which increases adipose tissue energy expenditure. Adipocytes can also release irisin after exercise, acting as a local adipokine to induce white adipose tissue to take on a brown adipose tissue-like phenotype, suggesting that irisin and its receptor may represent a novel molecular target for the treatment of obesity and obesity-related diabetes. Previous reports provide conflicting evidence regarding circulating irisin levels in patients with type 2 diabetes (T2DM)...
November 9, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29119963/-what-physiotherapeutic-method-for-the-treatment-of-post-mastectomy-lymphedema-is-the-most-effective
#13
T I Grushina
We have undertaken the search for the publications of interest in the following databases: Scopus, Web of Science, MedLine, The Cochrane Library, CyberLeninka, and Russian science citation index. In addition, we evaluated the effectiveness of the physical agents and procedures having different mechanisms of action of the known factors responsible for the development of post-mastectomy lymphedema. Such agents and procedures include self-massage, manual lymphatic drainage, therapeutic physical exercises, compression bandaging, wearing elastic compression garments, Kinesio Tex taping, pneumatic compression, ultrasonic, electrostatic, extracorporeal shock wave therapy, electrical muscle stimulation, microcurrent and low-intensity laser therapy...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29115485/effect-of-willed-movement-training-on-neurorehabilitation-after-focal-cerebral-ischemia-and-on-the-neural-plasticity-associated-signaling-pathway
#14
Zhi-Wen Zhou, Qi-Dong Yang, Qing-Ping Tang, Jie Yang, Rong-Jing Guo, Wen Jiang
Neurorehabilitation training is a therapeutic intervention for the loss of neural function induced by focal cerebral ischemia, however, the effect varies depending on the neurorehabilitation exercises. Willed movement (WM) training is defined as task‑oriented training, which increases enthusiasm of patients to accomplish a specific task. The current study was performed to the evaluate effect of WM training on neurorehabilitation following focal cerebral ischemia, and further investigate the influence on neural plasticity‑associated signaling pathway...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29114887/cough-strength-and-expiratory-force-in-aspirating-and-nonaspirating-postradiation-head-and-neck-cancer-survivors
#15
Katherine A Hutcheson, Martha P Barrow, Carla L Warneke, Yiqun Wang, George Eapen, Stephen Y Lai, Denise A Barringer, Emily K Plowman, Jan S Lewin
OBJECTIVE: Expiratory functions that clear aspiration from the airway are compromised in patients with neurogenic dysphagia for whom cough and expiratory force may be impaired by the primary disease process. The relationship between expiratory function, cough, and aspiration is less clear in head and neck cancer (HNC) survivors for whom the disease process does not directly impact the lower respiratory system. Our objective was to compare mechanisms of airway clearance (expiratory force and cough) with aspiration status in postradiated HNC survivors...
November 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29113760/strengths-weaknesses-and-future-challenges-of-biosimilars-development-an-opinion-on-how-to-improve-the-knowledge-and-use-of-biosimilars-in-clinical-practice
#16
Cristina Scavone, Concetta Rafaniello, Liberato Berrino, Francesco Rossi, Annalisa Capuano
Biosimilars started receiving the marketing authorization by European Medicine Agency since 2006. The development of biosimilars follows a well-defined step-wise approach, the so-called comparability exercise, which aims to compare non-clinical (mainly quality features and biological activity) and clinical (efficacy and safety profiles) features of new biosimilars with their respective reference products. Despite the undeniable advantages of such procedure, some concerns (such as the absence of switching studies or the evaluation of efficacy and safety in all therapeutic indications) still exist about its...
November 4, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29113570/a-novel-downhill-gait-training-program-following-a-total-knee-arthroplasty-a-case-report-highlighting-the-impacts-of-self-selected-speed-on-gait-symmetry
#17
Cody Blue, Sara Coomes, Yuri Yoshida
Study Design Case report. Background Walking plays an essential role in activities of daily living that lead to varied health benefits. Studies report gait speed and symmetry are impacted in individuals following TKA. Unfortunately, abnormal gait patterns persistently exist in individuals after TKA. Downhill walking may provide a simple and feasible exercise regimen to improve gait patterns. The purpose of this case report is to describe the application of a downhill treadmill training program and the subsequent changes in gait patterns in an individual following a unilateral TKA...
November 7, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29110366/energy-dissipation-differs-between-females-with-and-without-chronic-ankle-instability
#18
Ryan S McCann, Masafumi Terada, Kyle B Kosik, Phillip A Gribble
Chronic ankle instability (CAI) is associated with altered energy dissipation patterns, but comparisons to lateral ankle sprain (LAS) copers have not been explored. The purpose of this study was to examine differences in relative sagittal plane energy dissipation during a single-leg landing between female CAI and LAS coper participants. We separated 33 females (23.6±4.6yrs, 164.3±6.2cm, 69.4±13.7kg) into CAI (n=17) and LAS coper (n=16) groups. Participants completed five single-leg landings followed by a 5-second stabilization...
November 7, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29108873/the-comparison-of-the-effectiveness-of-conventional-therapeutic-exercises-and-pilates-on-pain-and-function-in-patients-with-knee-osteoarthritis
#19
Vahid Mazloum, Pouya Rabiei, Nader Rahnama, Elnaz Sabzehparvar
The aim of this study was to investigate the effectiveness of two different interventions on pain and disability in patients with knee osteoarthritis (KOA). Forty-one individuals (Mean ± SD: Age 52.1 ± 8.9 years, Height 172.8 ± 6.6 cm, Weight 80.2 ± 6.9 kg) with KOA were randomly allocated into Pilates (N = 14), conventional therapeutic exercise (CTE) (N = 14), and control (N = 13) groups. Joint position sense (JPS), functional performance, pain, and disability were examined using Biodex system, aggregate time of four daily activities, and Lequesne Index...
October 22, 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29102726/differential-gene-expression-analysis-in-ageing-muscle-and-drug-discovery-perspectives
#20
REVIEW
Aicha Melouane, Abdelaziz Ghanemi, Simon Aubé, Mayumi Yoshioka, Jonny St-Amand
Identifying therapeutic target genes represents the key step in functional genomics-based therapies. Within this context, the disease heterogeneity, the exogenous factors and the complexity of genomic structure and function represent important challenges. The functional genomics aims to overcome such obstacles via identifying the gene functions and therefore highlight disease-causing genes as therapeutic targets. Genomic technologies promise to reshape the research on ageing muscle, exercise response and drug discovery...
November 1, 2017: Ageing Research Reviews
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