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JM Gamble

W Abu-Ashour, L Chibrikova, W K Midodzi, L K Twells, J-M Gamble
AIM: To examine the patient characteristics associated with early initiation of insulin after a diagnosis of Type 2 diabetes. METHODS: We analysed cross-sectional data from the 2012 Canadian Community Health Survey conducted by Statistics Canada. Multivariable logistic regression was used to explore the association between patient sociodemographic and health status characteristics and initiating insulin within 1 year of a diagnosis of Type 2 diabetes (early insulin use)...
February 2017: Diabetic Medicine: a Journal of the British Diabetic Association
A Tawfik, Jm Rhodes, Bj Campbell
INTRODUCTION: Mucosa-associated adherent, invasive E.coli (AIEC), found in increased number in Crohn disease (CD) ileal and colonic mucosa, can replicate within host mucosal macrophages(.1,2) Other pathogens, known to survive within macrophages (e.g. Mycobacteria and Salmonella), possess stress-response inducible systems that allow them to tolerate environmental stress. Here we aimed to establish whether CD AIEC are better able than non-AIEC E.coli to tolerate low pH, high nitrosative and oxidative stress conditions, that mimic the environment within the macrophage phagolysosome...
June 2014: Gut
H Simpson, A V Keita, Jd Söderholm, Jm Rhodes, Bj Campbell
INTRODUCTION: Pathogen-related diarrhoea causes significant morbidity and mortality worldwide. Our studies have previously shown that soluble dietary fibre (non-starch polysaccharides, NSP), particularly from plantain bananas, can inhibit epithelial adherence of diarrhoeal pathogens in vitro and ex vivo (J. Nutr. Biochem.2013;24:97-103). METHODS: Here we aimed to establish whether plantain NSP exerts its inhibitory effect on pathogen adhesion to intestinal epithelium through either interaction with bacterial carbohydrate-binding proteins (adhesins) or via action on the epithelium itself...
June 2014: Gut
Pk Flanagan, S Subramanian, Bj Campbell, Jm Rhodes
INTRODUCTION: Patients with Crohn's disease exhibit an attenuated inflammatory response after trauma or Escherichia coli infection and have delayed clearance of subcutaneous bacteria compared to healthy controls. Adherent, invasive E. coli, increased in Crohn's disease, replicate within macrophages and may have a primary pathogenic role. Crohn's disease patients' macrophages may have a primary defect in bacterial killing, allowing survival of AIEC. METHODS: We aimed to assess the relative ability of monocyte-derived macrophages from Crohn's patients to kill intracellular E...
June 2014: Gut
Jm Gamble, Scot H Simpson, Lauren C Brown, Jeffrey A Johnson
BACKGROUND: Although evidence-based guidelines for the treatment of type 2 diabetes mellitus provide clear recommendations for initial therapy, evidence on an optimal treatment strategy after secondary failure is unclear. PURPOSE: To compare the efficacy of add-on therapy using basal insulin versus an additional oral antidiabetic agent in patients with type 2 diabetes and secondary failure. DATA SOURCES: We searched the following electronic databases from inception until June 2007: MEDLINE; EMBASE; Cochrane Central Register of Controlled Trials; Web of Science; Scopus; CINAHL; International Pharmaceutical Abstracts; Academic OneFile; PASCAL; Global Health Database; LILACS; HealthSTAR; PubMed...
2008: Open Medicine: a Peer-reviewed, Independent, Open-access Journal
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