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https://www.readbyqxmd.com/read/28098161/modelling-of-occupational-exposure-to-inhalable-nickel-compounds
#1
Benjamin Kendzia, Beate Pesch, Dorothea Koppisch, Rainer Van Gelder, Katrin Pitzke, Wolfgang Zschiesche, Thomas Behrens, Tobias Weiss, Jack Siemiatycki, Jerome Lavoué, Karl-Heinz Jöckel, Roger Stamm, Thomas Brüning
The aim of this study was to estimate average occupational exposure to inhalable nickel (Ni) using the German exposure database MEGA. This database contains 8052 personal measurements of Ni collected between 1990 and 2009 in adjunct with information on the measurement and workplace conditions. The median of all Ni concentrations was 9 μg/m(3) and the 95th percentile was 460 μg/m(3). We predicted geometric means (GMs) for welders and other occupations centered to 1999. Exposure to Ni in welders is strongly influenced by the welding process applied and the Ni content of the used welding materials...
January 18, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/28098065/the-treatment-of-post-thrombotic-syndrome
#2
Karina Schleimer, Mohammad Esmaeil Barbati, Alexander Gombert, Volker Wienert, Jochen Grommes, Houman Jalaie
BACKGROUND: Post-thrombotic syndrome (PTS) arises in 20-50% of patients who have sustained a deep vein thrombosis and markedly impairs their quality of life. METHODS: This review is based on pertinent publications retrieved by a selective literature search in PubMed and the Cochrane Library, and on the guidelines of the German Societies of Phlebology and Vascular Surgery (Deutsche Gesellschaft für Phlebologie, Deutsche Gesellschaft für Gefässchirurgie). RESULTS: The treatment options are conservative treatment with compression and patient exercises, endovascular recanalization with stent angioplasty, and open bypass surgery of the iliac obstructions...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28098063/the-use-of-e-cigarettes
#3
Martin Eichler, Maria Blettner, Susanne Singer
BACKGROUND: Electronic cigarettes (e-cigarettes) are a consumer product whose benefits and risks are currently debated. Advocates of the "tobacco harm reduction" strategy emphasize their potential as an aid to smoking cessation, while advocates of the precautionary principle emphasize their risks instead. There have been only a few studies to date on the prevalence of e-cigarette use in Germany. METHODS: In May 2016, in collaboration with Forsa, an opinion research firm, we carried out a survey among 4002 randomly chosen persons aged 14 and older, asking them about their consumption of e-cigarettes with and without nicotine, reasons for using e-cigarettes, plans for future use, estimation of danger compared to that of tobacco products, smoking behavior, and sociodemographic features...
December 16, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28097610/on-the-interdependence-of-ambulatory-and-hospital-care-in-the-german-health-system
#4
Tugba Büyükdurmus, Thomas Kopetsch, Hendrik Schmitz, Harald Tauchmann
For some considerable time now the interface between ambulatory and hospital care has been mooted as a cause of inefficiencies in the German health system and there have been calls for a softening of the strict separation between the two sectors. This debate emphasizes the need for detailed empirical information on the interdependence between the two sectors. Using extensive administrative data at the level of the 412 German counties for the years 2007 to 2009 and a simultaneous equation model which allows the numbers of ambulatory and hospital cases to be mutually interdependent, we examine the connection between ambulatory and hospital specialist care separately for ten medical specialties...
December 2017: Health Economics Review
https://www.readbyqxmd.com/read/28097433/early-integration-of-palliative-supportive-cancer-care-healthcare-professionals-perspectives-on-the-support-needs-of-cancer-patients-and-their-caregivers-across-the-cancer-treatment-trajectory
#5
Amy Rohrmoser, Martina Preisler, Konrad Bär, Anne Letsch, Ute Goerling
PURPOSE: Delivering palliative/supportive cancer care (PSCC) early in the course of cancer care can enhance patients' and caregivers' quality of life, reduce anxiety and depression, and prolong patients' lives. However, their support needs are analyzed insufficiently from viewpoints other than their own. The goal of this study was to explore the perspectives of healthcare professionals on desirable standards of support for tumor patients and caregivers across the cancer treatment trajectory...
January 17, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28097013/randomised-double-blind-clinical-investigation-to-compare-orlistat-60-milligram-and-a-customized-polyglucosamine-two-treatment-methods-for-the-management-of-overweight-and-obesity
#6
Manfred Stoll, Norman Bitterlich, Umberto Cornelli
BACKGROUND: The efficacy of a non-prescription drug to support weight loss programs has yet to be compared. This clinical trial investigates the comparability of orlistat 60 milligram (mg) and polyglucosamine. METHODS: Sixty-four overweight or obese subjects were included in a two-center double-blind study. One center was in Germany [center 1] and the other was in Italy [center 2]. The subjects (26 in center 1 and 38 in center 2) were recommended to follow a calorie deficit of about 2000 kilojoules/day and to increase their physical activity to 3 metabolic equivalent hours (MET h)/day...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28095908/limiting-treatment-and-shortening-of-life-data-from-a-cross-sectional-survey-in-germany-on-frequencies-determinants-and-patients-involvement
#7
Birte Malena Dahmen, Jochen Vollmann, Stephan Nadolny, Jan Schildmann
BACKGROUND: Limiting treatment forms part of practice in many fields of medicine. There is a scarcity of robust data from Germany. Therefore, in this paper, we report results of a survey among German physicians with a focus on frequencies, aspects of decision making and determinants of limiting treatment with expected or intended shortening of life. METHODS: Postal survey among a random sample of physicians working in the area of five German state chambers of physicians using a modified version of the questionnaire of the EURELD Consortium...
January 17, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28095278/awareness-of-hiv-transmission-risks-and-determinants-of-sexual-behaviour-descriptive-and-multivariate-analyses-among-german-nursing-students
#8
Carolin Jacob, Katharina von Lindeman, Jörg Klewer, Joachim Kugler
AIM: Nursing students play a crucial role in sexual health education. Evidence suggests, however, that nursing students had several gaps in their knowledge of HIV transmission. This study investigates how nursing students in Germany assess the potential risks of spreading HIV in defined situations and which factors influence the self-expressed sexual behaviour patterns of these students. METHODS: A standardized anonymous questionnaire was administered to a sample (N=617) of nursing students in 2008 and 2013...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28095033/detection-of-the-toughest-pedestrian-injury-risk-as-a-smooth-function-of-age
#9
Tobias Niebuhr, Mirko Junge
OBJECTIVE: While it is common to regard age-specific groups (e.g. children, adults, elderly), smooth trends conditional on the age are mainly ignored in the literature. The present study examines the pedestrian injury risk in full-frontal pedestrian to passenger car accidents and incorporates the age -besides the collision speed and the injury severity- as a plug-in parameter. METHODS: Recent work introduced a model for pedestrian injury risk functions using explicit formulae with easily interpretable model parameters...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28095011/investigating-developmental-trajectories-of-morphemes-as-reading-units-in-german
#10
Jana Hasenäcker, Pauline Schröter, Sascha Schroeder
The developmental trajectory of the use of morphemes is still unclear. We investigated the emergence of morphological effects on visual word recognition in German in a large sample across the complete course of reading acquisition in elementary school. To this end, we analyzed lexical decision data on a total of 1,152 words and pseudowords from a large cross-sectional sample of German children from the beginning of Grade 2 through 6, and a group of adults. We expand earlier evidence by (a) explicitly investigating processing differences between compounds, prefixes and suffixes, (b) taking into account vocabulary knowledge as an indicator for interindividual differences...
January 16, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28094826/response-to-dittrich-et-al-non-embryo-destructive-extraction-of-pluripotent-embryonic-stem-cells-overlooked-legal-prohibitions-professional-legal-consequences-and-inconsistencies-in-patent-law
#11
REVIEW
T Faltus, U Storz
The publication of "Non-embryo-destructive Extraction of Pluripotent Embryonic Stem Cells: Implications for Regenerative Medicine and Reproductive Medicine" by Dittrich et al. in Geburtshilfe und Frauenheilkunde 2015; 75: 1239-1242 1 describes various possibilities which could result from the non-embryo-destructive extraction of embryonic stem cells from human blastocysts. But implementing this method is more problematic, both legally and ethically, than the authors have represented it to be and is illegal in Germany...
December 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28094416/-seasonal-leukotrichia-in-a-german-shepherd-dog-a-case-report
#12
Janine Classen, Sonya V Bettenay, Ralf S Mueller
Leukotrichia can be caused by a variety of metabolic and inflammatory diseases. Canine alopecia areata is a rare multifactorial benign non-scarring alopecia. This case report describes a seasonally recurrent leukotrichia associated with alopecia areata in a German shepherd dog. Important differential diagnoses were ruled out and histopathology finally confirmed the diagnosis of alopecia areata. Topical tacrolimus and hydrocortisone aceponate were ineffective. The cause for the seasonal character in this case remained undetermined...
January 17, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28094198/late-side-effects-and-cosmetic-results-of-accelerated-partial-breast-irradiation-with-interstitial-brachytherapy-versus-whole-breast-irradiation-after-breast-conserving-surgery-for-low-risk-invasive-and-in-situ-carcinoma-of-the-female-breast-5-year-results
#13
Csaba Polgár, Oliver J Ott, Guido Hildebrandt, Daniela Kauer-Dorner, Hellen Knauerhase, Tibor Major, Jaroslaw Lyczek, José Luis Guinot, Jürgen Dunst, Cristina Gutierrez Miguelez, Pavel Slampa, Michael Allgäuer, Kristina Lössl, Bülent Polat, György Kovács, Arnt-René Fischedick, Rainer Fietkau, Alexandra Resch, Anna Kulik, Leo Arribas, Peter Niehoff, Ferran Guedea, Annika Schlamann, Richard Pötter, Christine Gall, Wolfgang Uter, Vratislav Strnad
BACKGROUND: We previously confirmed the non-inferiority of accelerated partial breast irradiation (APBI) with interstitial brachytherapy in terms of local control and overall survival compared with whole-breast irradiation for patients with early-stage breast cancer who underwent breast-conserving surgery in a phase 3 randomised trial. Here, we present the 5-year late side-effects and cosmetic results of the trial. METHODS: We did this randomised, controlled, phase 3 trial at 16 centres in seven European countries...
January 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28093724/the-potential-of-high-dimensional-propensity-scores-in-health-services-research-an-exemplary-study-on-the-quality-of-care-for-elective-percutaneous-coronary-interventions
#14
Dirk Enders, Christoph Ohlmeier, Edeltraut Garbe
OBJECTIVE: Evaluating the potential of the high-dimensional propensity score (HDPS) to control for residual confounding in studies analyzing quality of care based on administrative health insurance data. DATA SOURCE: Secondary data from 2004 to 2009 from three German statutory health insurance providers. STUDY DESIGN: We conducted a retrospective cohort study in patients with elective percutaneous coronary interventions (PCIs) and compared the mortality risk between the in- and outpatient setting using Cox regression...
January 16, 2017: Health Services Research
https://www.readbyqxmd.com/read/28093627/-validation-of-the-german-version-of-the-6%C3%A2-item-screener-brief-cognitive-test-with-broad-application-possibilities
#15
S Krupp, A Seebens, J Kasper, M Willkomm, F Balck
BACKGROUND: Especially during admission the detection of cognitive deficits relevant to everyday life should burden patient and examiner as little as possible. The 6‑item screener (SIS) takes approximately 1 min, is easy to learn, does not require any material and is independent of the patient's visual and fine motor skills. The test was first published in 2002 by Callahan who approved the present German translation. OBJECTIVE: We checked the convergent and discriminant validity, reliability and sensitivity to change of the German translation among geriatric patients...
January 16, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28093615/the-open-abdomen-route-by-eurahs-introduction-of-the-data-set-and-initial-results-of-procedures-and-procedure-related-complications
#16
A Willms, F Muysoms, C Güsgen, R Schwab, J Lock, S Schaaf, C Germer, I Richardsen, U Dietz
INTRODUCTION: Open abdomen management has become a well-established strategy in the treatment of serious intra-abdominal pathologies. Key objectives are fistula prevention and high fascial closure rates. The current level of evidence on laparostoma is insufficient. This is due to the rareness of laparostomas, the heterogeneity of study cohorts, and broad diversity of techniques. Collecting data in a standardised, multicentre registry is necessary to draw up evidence-based guidelines. MATERIALS AND METHODS: In order to improve the level of evidence on laparostomy, CAMIN (surgical working group for military and emergency surgery) of DGAV (German Society for General and Visceral Surgery), initiated the implementation of a laparostomy registry...
January 16, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28093484/mic-of-amoxicillin-clavulanate-according-to-clsi-and-eucast-discrepancies-and-clinical-impact-in-patients-with-bloodstream-infections-due-to-enterobacteriaceae
#17
Mercedes Delgado-Valverde, Adoración Valiente-Mendez, Eva Torres, Benito Almirante, Silvia Gómez-Zorrilla, Nuria Borrell, Ana Isabel Aller-García, Mercedes Gurgui, Manel Almela, Mercedes Sanz, Germán Bou, Luis Martínez-Martínez, Rafael Cantón, Jose Antonio Lepe, Manuel Causse, Belén Gutiérrez-Gutiérrez, Álvaro Pascual, Jesús Rodríguez-Baño
OBJECTIVES: To compare results of amoxicillin/clavulanate susceptibility testing using CLSI and EUCAST methodologies and to evaluate their impact on outcome in patients with bacteraemia caused by Enterobacteriaceae. PATIENTS AND METHODS: A prospective observational cohort study was conducted in 13 Spanish hospitals. Patients with bacteraemia due to Enterobacteriaceae who received empirical intravenous amoxicillin/clavulanate treatment for at least 48 h were included...
January 15, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28092642/the-number-of-patients-with-chronic-hepatitis-c-in-times-of-new-therapy-options-a-retrospective-observational-study-on-german-health-insurance-funds-data
#18
Stefanie Thönnes, Heiko Friedel, Heike Fröhlich
AIM/OBJECTIVES/BACKGROUND: Chronic hepatitis C (CHC) virus infection is a leading cause of liver-related morbidity and mortality. In Germany, as in many other countries, there is a lack of comprehensive epidemiological data. Routine data from sickness funds can support the estimation of the true prevalence and incidence of CHC. METHODS: In this article, the results of annual and quarterly analyses of prevalence and incidence for the years 2007-2013 are presented using data of several German sickness funds...
January 12, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28092273/in-vivo-testing-of-extracorporeal-membrane-ventilators-ila-activve%C3%A2-vs-prototype-i-lung%C3%A2
#19
Sabine Kischkel, Stefan Bergt, Beate Brock, Johan von Grönheim, Anne Herbst, Marc-Jonas Epping, Georg Matheis, Esther Novosel, Joerg Schneider, Philipp Warnke, Andreas Podbielski, Jan P Roesner, Peter I Lelkes, Brigitte Vollmar
A side-by-side comparison of the decarboxylation efficacy of two pump-driven veno-venous extracorporeal lung assist devices, i.e. a first prototype of the new miniaturized ambulatory extracorporeal membrane ventilator, I-lung® versus the commercial system iLA-activve® over a period of 72 hours in a large animal model.Fifteen German Landrace pigs were anesthetized and underwent mechanical hypoventilation to induce severe hypercapnia. Decarboxylation was accomplished by either the I-lung® or the iLA-activve® via a double lumen catheter in the jugular vein...
January 4, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28092192/do-i-feel-ill-because-i-crave-for-work-or-do-i-crave-for-work-because-i-feel-ill-a-longitudinal-analysis-of-work-craving-self-regulation-and-health
#20
Kamila Wojdylo, Wilhelm Karlsson, Nicola Baumann
Background The theory of work craving defines workaholism as a pathological work addiction which comprises: (a) obsessive-compulsive desire to work, (b) anticipation of self-worth compensatory incentives from working, (c) anticipation of reduction of negative emotions or withdrawal symptoms from working, and (d) neurotic perfectionism. Research has shown that workaholism is associated with adverse health outcomes. However, the antecedents of workaholism and the causal direction of the relationship with health have been largely neglected...
March 2016: Journal of Behavioral Addictions
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