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https://www.readbyqxmd.com/read/28441528/phosphorylation-of-neurog3-links-endocrine-differentiation-to-the-cell-cycle-in-pancreatic-progenitors
#1
Nicole A J Krentz, Dennis van Hoof, Zhongmei Li, Akie Watanabe, Mei Tang, Cuilan Nian, Michael S German, Francis C Lynn
During pancreatic development, proliferating pancreatic progenitors activate the proendocrine transcription factor neurogenin 3 (NEUROG3), exit the cell cycle, and differentiate into islet cells. The mechanisms that direct robust NEUROG3 expression within a subset of progenitor cells control the size of the endocrine population. Here we demonstrate that NEUROG3 is phosphorylated within the nucleus on serine 183, which catalyzes its hyperphosphorylation and proteosomal degradation. During progression through the progenitor cell cycle, NEUROG3 phosphorylation is driven by the actions of cyclin-dependent kinases 2 and 4/6 at G1/S cell-cycle checkpoint...
April 24, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28441386/graft-derived-cell-free-dna-a-noninvasive-early-rejection-and-graft-damage-marker-in-liver-transplantation-a-prospective-observational-multicenter-cohort-study
#2
Ekkehard Schütz, Anna Fischer, Julia Beck, Markus Harden, Martina Koch, Tilo Wuensch, Martin Stockmann, Björn Nashan, Otto Kollmar, Johannes Matthaei, Philipp Kanzow, Philip D Walson, Jürgen Brockmöller, Michael Oellerich
BACKGROUND: Graft-derived cell-free DNA (GcfDNA), which is released into the blood stream by necrotic and apoptotic cells, is a promising noninvasive organ integrity biomarker. In liver transplantation (LTx), neither conventional liver function tests (LTFs) nor immunosuppressive drug monitoring are very effective for rejection monitoring. We therefore hypothesized that the quantitative measurement of donor-derived cell-free DNA (cfDNA) would have independent value for the assessment of graft integrity, including damage from acute rejection...
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28441085/noun-and-verb-knowledge-in-monolingual-preschool-children-across-17-languages-data-from-cross-linguistic-lexical-tasks-litmus-clt
#3
Ewa Haman, Magdalena Łuniewska, Pernille Hansen, Hanne Gram Simonsen, Shula Chiat, Jovana Bjekić, Agnė Blažienė, Katarzyna Chyl, Ineta Dabašinskienė, Pascale Engel de Abreu, Natalia Gagarina, Anna Gavarró, Gisela Håkansson, Efrat Harel, Elisabeth Holm, Svetlana Kapalková, Sari Kunnari, Chiara Levorato, Josefin Lindgren, Karolina Mieszkowska, Laia Montes Salarich, Anneke Potgieter, Ingeborg Ribu, Natalia Ringblom, Tanja Rinker, Maja Roch, Daniela Slančová, Frenette Southwood, Roberta Tedeschi, Aylin Müge Tuncer, Özlem Ünal-Logacev, Jasmina Vuksanović, Sharon Armon-Lotem
This article investigates the cross-linguistic comparability of the newly developed lexical assessment tool Cross-linguistic Lexical Tasks (LITMUS-CLT). LITMUS-CLT is a part the Language Impairment Testing in Multilingual Settings (LITMUS) battery (Armon-Lotem, de Jong & Meir, 2015). Here we analyse results on receptive and expressive word knowledge tasks for nouns and verbs across 17 languages from eight different language families: Baltic (Lithuanian), Bantu (isiXhosa), Finnic (Finnish), Germanic (Afrikaans, British English, South African English, German, Luxembourgish, Norwegian, Swedish), Romance (Catalan, Italian), Semitic (Hebrew), Slavic (Polish, Serbian, Slovak) and Turkic (Turkish)...
April 25, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28441027/cardiac-morphometry-on-computed-tomography-and-exacerbation-reduction-with-%C3%AE-blocker-therapy-in-copd
#4
Surya P Bhatt, Gonzalo Vegas-Sánchez-Ferrero, Farbod N Rahaghi, Erick S MacLean, German Gonzalez-Serrano, Carolyn E Come, Gregory L Kinney, John E Hokanson, Matthew J Budoff, Michael J Cuttica, J Michael Wells, Raúl San José Estépar, George R Washko
No abstract text is available yet for this article.
April 25, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28440286/size-and-shape-variations-of-the-bony-components-of-sperm-whale-cochleae
#5
Joseph G Schnitzler, Bruno Frédérich, Sven Früchtnicht, Tobias Schaffeld, Johannes Baltzer, Andreas Ruser, Ursula Siebert
Several mass strandings of sperm whales occurred in the North Sea during January and February 2016. Twelve animals were necropsied and sampled around 48 h after their discovery on German coasts of Schleswig Holstein. The present study aims to explore the morphological variation of the primary sensory organ of sperm whales, the left and right auditory system, using high-resolution computerised tomography imaging. We performed a quantitative analysis of size and shape of cochleae using landmark-based geometric morphometrics to reveal inter-individual anatomical variations...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#6
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28439612/-imaging-of-the-paranasal-sinuses-and-anterior-skull-base
#7
S Greschus, F Albert, K W G Eichhorn
Due to the complex anatomy of the anterior skull base and paranasal sinuses, radiologic diagnostics in this area are challenging. Magnetic resonance imaging (MRI) and computed tomography (CT) are the primary indicated modalities. Guidelines helping to select the appropriate modality have been published by the German Society of Head and Neck Radiology and the Society of Otorhinolaryngology. The present article presents an overview of the current radiologic procedures and their optimized implementation using clinical examples...
April 21, 2017: HNO
https://www.readbyqxmd.com/read/28439242/comprehensive-psychopathological-assessment-based-on-the-association-for-methodology-and-documentation-in-psychiatry-amdp-system-development-methodological-foundation-application-in-clinical-routine-and-research
#8
REVIEW
Rolf-Dieter Stieglitz, Achim Haug, Erdmann Fähndrich, Michael Rösler, Wolfgang Trabert
The documentation of psychopathology is core to the clinical practice of the psychiatrist and clinical psychologist. However, both in initial as well as further training and specialization in their fields, this particular aspect of their work receives scanty attention only. Yet, for the past 50 years, the Association for Methodology and Documentation in Psychiatry (AMDP) System has been in existence and available as a tool to serve precisely the purpose of offering a systematic introduction to the terminology and documentation of psychopathology...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28438727/influence-of-telecommunication-modality-internet-transmission-quality-and-accessories-on-speech-perception-in-cochlear-implant-users
#9
Georgios Mantokoudis, Roger Koller, Jérémie Guignard, Marco Caversaccio, Martin Kompis, Pascal Senn
BACKGROUND: Telecommunication is limited or even impossible for more than one-thirds of all cochlear implant (CI) users. OBJECTIVE: We sought therefore to study the impact of voice quality on speech perception with voice over Internet protocol (VoIP) under real and adverse network conditions. METHODS: Telephone speech perception was assessed in 19 CI users (15-69 years, average 42 years), using the German HSM (Hochmair-Schulz-Moser) sentence test comparing Skype and conventional telephone (public switched telephone networks, PSTN) transmission using a personal computer (PC) and a digital enhanced cordless telecommunications (DECT) telephone dual device...
April 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28438254/validity-and-reliability-of-the-spanish-version-of-the-somatoform-dissociation-questionnaire-sdq-20
#10
Ana I González-Vázquez, Lucía Del Río-Casanova, Natalia Seijo-Ameneiros, Paloma Cabaleiro-Fernández, Teresa Seoane-Pillado, Ania Justo-Alonso, Miguel A Santed-Germán
BACKGROUND: The Somatoform Dissociation Questionnaire (SDQ-20) is a self-reported questionnaire measuring somatoform dissociation. The aim of this study is to analyze the psychometric properties of the Spanish version of the SDQ-20 and its short version (SDQ-5). METHODS: Validity and reliability were examined in a sample of 360 psychiatric outpatients: 38 dissociative (conversion) disorders, 30 dissociative (psychoform) disorders, and 292 patients suffering from other disorders...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28438112/h3n2-canine-influenza-virus-infection-in-a-dog
#11
C E Watson, C Bell, K Toohey-Kurth
In 2015, H3N2 canine influenza emerged in dogs in the greater Chicago area. During this time, a 10-year-old German Shepherd dog presented to the referring veterinarian with lethargy and coughing that quickly progressed to death. This report describes the macroscopic and microscopic lesions and the molecular testing performed to identify the novel North American H3N2 strain of canine influenza. The larynx, pharynx, and trachea were covered by a fibrinonecrotic membrane. Bilaterally, the lungs had multifocal subpleural necrosis of the caudal lung lobes with hemorrhage, congestion, and pulmonary edema...
May 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28437823/-medicolegal-assessment-of-psychic-sequelae-after-minor-traumatic-events
#12
Bernhard Widder
The majority of medicolegal assessments in claimed psychic sequelae after accidents concerns minor traumatic events. In this case, the focus is on three questions: Was the event appropriate to cause a traumatic disturbance according to current psychiatric classification systems (especially current DSM-5)? Which psychical or physical initial injury can be proven beyond reasonable doubt ("full proof") according to German law? What is the impact of personality characteristics and competing life events in the development and maintenance of the mental disorder? Causality between mental disorders and minor traumatic events is to be confirmed especially in the case of persistent physical accident sequelae, but attention has to be paid to the differences in the various legal requirements...
April 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28437802/surveillance-after-resection-of-pancreatic-ductal-adenocarcinoma-with-curative-intent-a-multicenter-survey-in-germany-and-review-of-the-literature
#13
Thomas J Ettrich, Lucas A Schulte, Natalie Eitel, Kristin Ettrich, Andreas W Berger, Lukas Perkhofer, Thomas Seufferlein
Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high risk of relapse even after curative-intended resection. There are no evidence-based recommendations for surveillance in actual guidelines. Given this situation and as a basis for prospective studies, we wanted to determine the current practice of surveillance after pancreatic cancer resection in German institutions. Methods A web-based questionnaire was sent in 2015 to 300 German institutions (hospitals, outpatient clinics, and private practices) experienced in the care of patients with PDAC...
April 24, 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28437523/emergency-department-query-for-patient-centered-approaches-to-sexual-orientation-and-gender-identity-the-equality-study
#14
Adil H Haider, Eric B Schneider, Lisa M Kodadek, Rachel R Adler, Anju Ranjit, Maya Torain, Ryan Y Shields, Claire Snyder, Jeremiah D Schuur, Laura Vail, Danielle German, Susan Peterson, Brandyn D Lau
Importance: The Institute of Medicine and The Joint Commission recommend routine documentation of patients' sexual orientation in health care settings. Currently, very few health care systems collect these data since patient preferences and health care professionals' support regarding collection of data about patient sexual orientation are unknown. Objective: To identify the optimal patient-centered approach to collect sexual orientation data in the emergency department (ED) in the Emergency Department Query for Patient-Centered Approaches to Sexual Orientation and Gender Identity study...
April 24, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28437243/impact-of-pulmonary-hypertension-on-in-hospital-outcome-after-surgical-or-transcatheter-aortic-valve-replacement
#15
Anja Gutmann, Klaus Kaier, Holger Reinecke, Lutz Frankenstein, Andreas Zirlik, Wolfgang Bothe, Constantin von Zur Mühlen, Manfred Zehender, Jochen Reinöhl, Christoph Bode, Peter Stachon
AIMS: The impact of pulmonary hypertension (PH) on in-hospital outcome of either surgical (SAVR) or transcatheter aortic valve replacement (TAVR) was analyzed. METHODS AND RESULTS: Data from all 107,057 patients undergoing isolated SAVR or TAVR in Germany between 2007 and 2014 was provided by the German Federal Bureau of Statistics. About 18% of patients with aortic valve stenosis suffered from PH. Patients with PH had more co- morbidities with consequently increased EuroSCORE (TAVR without PH: 12...
April 25, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28436593/results-for-patients-with-sarcoma-not-otherwise-specified-and-other-diagnoses-than-ewing-sarcoma-treated-according-to-the-euro-ewing-99-trial
#16
Judith Amalie Frank, Andreas Ranft, Michael Paulussen, Heribert Juergens, Jarmila Kruseova, Sebastian Bauer, Felix Niggli, Peter Reichardt, Uta Dirksen
BACKGROUND: Euro-EWING 99 trial of the European Ewing tumor Working Initiative of National Groups (EE99) was an international phase III study in patients with Ewing sarcoma. The German Society of Pediatric Oncology and Hematology (GPOH) data center registered and followed patients with other diagnoses than Ewing sarcoma who were treated according to the EE99 protocol in an additional non-Ewing database. PROCEDURE: Data of 27 patients with other diagnoses than Ewing sarcoma treated according to the EE99 protocol were analyzed...
April 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28436126/celebrating-canadian-chemistry
#17
EDITORIAL
Douglas W Stephan, Mark Lautens
"… This issue of Angewandte Chemie commemorates the 100th anniversary of the Canadian Society for Chemistry. It contains contributions from Canadian and German chemists covering a broad and diverse array of subject areas. We are proud to reflect on the accomplishments of the Canadian chemical community and are excited about what the future holds …".
April 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28435474/the-vision-of-industrie-4-0-in-the-making-a-case-of-future-told-tamed-and-traded
#18
Sabine Pfeiffer
Since industrial trade fair Hannover Messe 2011, the term "Industrie 4.0" has ignited a vision of a new Industrial Revolution and has been inspiring a lively, ongoing debate among the German public about the future of work, and hence society, ever since. The discourse around this vision of the future eventually spread to other countries, with public awareness reaching a temporary peak in 2016 when the World Economic Forum's meeting in Davos was held with the motto "Mastering the Fourth Industrial Revolution...
2017: Nanoethics
https://www.readbyqxmd.com/read/28435280/high-adherence-to-therapy-and-low-cardiac-mortality-and-morbidity-in-patients-after-acute-coronary-syndrome-systematically-managed-by-office-based-cardiologists-in-germany-1-year-outcomes-of-the-proacor-study
#19
Franz Goss, Johannes Brachmann, Christian W Hamm, Winfried Haerer, Nicolaus Reifart, Benny Levenson
We aimed to assess patient acceptance and effectiveness of a 12-month structured management program in patients after an acute coronary syndrome (ACS) event who were treated in a special setting of office-based cardiologists. The program comprised patient documentation with a specific tool (Bundesverband Niedergelassener Kardiologen [German Federation of Office-Based Cardiologists] cardiac pass with visit scheduling) shared by the hospital physician and the office-based cardiologist, the definition of individual treatment targets, and the systematic information of patients in order to optimize adherence to therapy...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28435244/accelerometer-versus-questionnaire-based-assessment-of-physical-activity-and-their-changes-over-time-in-patients-with-copd
#20
Noriane A Sievi, Thomas Brack, Martin H Brutsche, Martin Frey, Sarosh Irani, Jörg D Leuppi, Robert Thurnheer, Malcolm Kohler, Christian F Clarenbach
BACKGROUND AND OBJECTIVE: Physical activity (PA) is an important outcome parameter in patients with COPD regarding hospitalizations and mortality. Both objective assessment by accelerometers and self-evaluation by questionnaires were used in studies investigating PA in COPD. Whether self-reported questionnaires can adequately reflect PA and its changes over time compared to objective assessments has not been thoroughly investigated in COPD. In this COPD cohort study, we evaluated whether PA measured by accelerometer and its annual changes can also be assessed by self-reported questionnaires...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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