keyword
MENU ▼
Read by QxMD icon Read
search

German

keyword
https://www.readbyqxmd.com/read/29342275/hot-spot-kif5a-mutations-cause-familial-als
#1
David Brenner, Rüstem Yilmaz, Kathrin Müller, Torsten Grehl, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Christoph Neuwirth, Markus Weber, Susana Pinto, Kristl G Claeys, Berthold Schrank, Berit Jordan, Antje Knehr, Kornelia Günther, Annemarie Hübers, Daniel Zeller, Christian Kubisch, Sibylle Jablonka, Michael Sendtner, Thomas Klopstock, Mamede de Carvalho, Anne Sperfeld, Guntram Borck, Alexander E Volk, Johannes Dorst, Joachim Weis, Markus Otto, Joachim Schuster, Kelly Del Tredici, Heiko Braak, Karin M Danzer, Axel Freischmidt, Thomas Meitinger, Tim M Strom, Albert C Ludolph, Peter M Andersen, Jochen H Weishaupt
Heterozygous missense mutations in the N-terminal motor or coiled-coil domains of the kinesin family member 5A (KIF5A) gene cause monogenic spastic paraplegia (HSP10) and Charcot-Marie-Tooth disease type 2 (CMT2). Moreover, heterozygous de novo frame-shift mutations in the C-terminal domain of KIF5A are associated with neonatal intractable myoclonus, a neurodevelopmental syndrome. These findings, together with the observation that many of the disease genes associated with amyotrophic lateral sclerosis disrupt cytoskeletal function and intracellular transport, led us to hypothesize that mutations in KIF5A are also a cause of amyotrophic lateral sclerosis...
January 12, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29342018/mini-or-less-open-sublay-operation-milos-a-new-minimally-invasive-technique-for-the-extraperitoneal-mesh-repair-of-incisional-hernias
#2
Wolfgang Reinpold, Michael Schröder, Cigdem Berger, Jennifer Nehls, Alexander Schröder, Martin Hukauf, Ferdinand Köckerling, Reinhard Bittner
OBJECTIVE: Improvement of ventral hernia repair. BACKGROUND: Despite the use of mesh and other recent improvements, the currently popular techniques of ventral hernia repair have specific disadvantages and risks. METHODS: We developed the endoscopically assisted mini- or less-open sublay (MILOS) concept. The operation is performed transhernially via a small incision with light-holding laparoscopic instruments either under direct, or endoscopic visualization...
January 16, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29341789/psychometric-properties-of-the-epworth-sleepiness-scale-a-factor-analysis-and-item-response-theory-approach
#3
June J Pilcher, Fred S Switzer, Alec Munc, Janet Donnelly, Julia C Jellen, Claus Lamm
The purpose of this study is to examine the psychometric properties of the Epworth Sleepiness Scale (ESS) in two languages, German and English. Students from a university in Austria (N = 292; 55 males; mean age = 18.71 ± 1.71 years; 237 females; mean age = 18.24 ± 0.88 years) and a university in the US (N = 329; 128 males; mean age = 18.71 ± 0.88 years; 201 females; mean age = 21.59 ± 2.27 years) completed the ESS. An exploratory-factor analysis was completed to examine dimensionality of the ESS...
January 17, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29341698/general-linearized-theory-of-quantum-fluctuations-around-arbitrary-limit-cycles
#4
Carlos Navarrete-Benlloch, Talitha Weiss, Stefan Walter, Germán J de Valcárcel
The theory of Gaussian quantum fluctuations around classical steady states in nonlinear quantum-optical systems (also known as standard linearization) is a cornerstone for the analysis of such systems. Its simplicity, together with its accuracy far from critical points or situations where the nonlinearity reaches the strong coupling regime, has turned it into a widespread technique, being the first method of choice in most works on the subject. However, such a technique finds strong practical and conceptual complications when one tries to apply it to situations in which the classical long-time solution is time dependent, a most prominent example being spontaneous limit-cycle formation...
September 29, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29341047/german-guideline-for-idiopathic-pulmonary-fibrosis-update-on-pharmacological-therapies-2017
#5
Jürgen Behr, Andreas Günther, Francesco Bonella, Klaus Geißler, Dirk Koschel, Michael Kreuter, Antje Prasse, Nicolas Schönfeld, Helmut Sitter, Joachim Müller-Quernheim, Ulrich Costabel
Idiopathic pulmonary fibrosis (IPF) is a severe and often fatal disease with a median survival of 2 - 4 years after diagnosis. Since the publication of the German IPF guideline in 2013 new treatment trials have been published, necessitating an update of the pharmacological therapy of IPF. Different from the previous guideline, the GRADE system was discarded and replaced by the Oxford evidence classification system which allows a more differentiated judgement. The following pharmacological therapies were rated not suitable for the treatment of IPF patients (recommendation A; evidence 1-b): triple therapy with prednisolone, azathioprine and acetyl-cysteine; imatinib; ambrisentan; bosentan; macitentan...
January 16, 2018: Pneumologie
https://www.readbyqxmd.com/read/29341041/screening-interval-recommendations-following-a-normal%C3%A2-colonoscopy-in-individuals-with-a-familial-risk-of%C3%A2-colorectal-cancer
#6
Jasper Plath, Andrea Siebenhofer, Corina Guethlin, Irina Blumenstein
BACKGROUND:  In view of the increased risk of developing colorectal cancer (CRC) in individuals with affected first-degree relatives (FDRs), the German evidence-based S3 guideline recommends having the first screening colonoscopy early and then, following a normal examination, repeating it at least every 10 years. The aim of this analysis was to explore colonoscopy interval recommendations in clinical practice among individuals aged < 55 years with a familial risk of CRC. METHODS:  We analyzed data from the FRIDA...
January 16, 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29341032/-epidemiology-diagnosis-and-treatment-of-adult-patients-with-nosocomial-pneumonia-update-2017-s3-guideline-of-the-german-society-for-anaesthesiology-and-intensive-care-medicine-the-german-society-for-infectious-diseases-the-german-society-for-hygiene-and-microbiology
#7
K Dalhoff, M Abele-Horn, S Andreas, M Deja, S Ewig, P Gastmeier, S Gatermann, H Gerlach, B Grabein, C P Heußel, G Höffken, M Kolditz, E Kramme, H Kühl, C Lange, K Mayer, I Nachtigall, M Panning, M Pletz, P-M Rath, G Rohde, S Rosseau, B Schaaf, D Schreiter, H Schütte, H Seifert, C Spies, T Welte
Nosocomial pneumonia (HAP) is a frequent complication of hospital care. Most data are available on ventilator-associated pneumonia. However, infections on general wards are increasing. A central issue are infections with multidrug resistant (MDR) pathogens which are difficult to treat in the empirical setting potentially leading to inappropriate use of antimicrobial therapy.This guideline update was compiled by an interdisciplinary group on the basis of a systematic literature review. Recommendations are made according to GRADE giving guidance for the diagnosis and treatment of HAP on the basis of quality of evidence and benefit/risk ratio...
January 2018: Pneumologie
https://www.readbyqxmd.com/read/29340799/fully-automated-life-support-an-implementation-and-feasibility-pilot-study-in-healthy-pigs
#8
Wilfried Klingert, Jörg Peter, Christian Thiel, Karolin Thiel, Wolfgang Rosenstiel, Kathrin Klingert, Christian Grasshoff, Alfred Königsrainer, Martin Schenk
BACKGROUND: Automated systems are available in various application areas all over the world for the purpose of reducing workload and increasing safety. However, such support systems that would aid caregivers are still lacking in the medical sector. With respect to workload and safety, especially, the intensive care unit appears to be an important and challenging application field. Whereas many closed-loop subsystems for single applications already exist, no comprehensive system covering multiple therapeutic aspects and interactions is available yet...
January 16, 2018: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29340770/-a-fresh-look-at-the-german-survey-on-aging
#9
Miranda Leontowitsch, Frank Oswald
No abstract text is available yet for this article.
January 16, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29340646/visual-fixation-instability-in-multiple-sclerosis-measured-using-slo-oct
#10
Robert M Mallery, Pieter Poolman, Matthew J Thurtell, Jan M Full, Johannes Ledolter, Dorlan Kimbrough, Elliot M Frohman, Teresa C Frohman, Randy H Kardon
Purpose: Precise measurements of visual fixation and its instability were recorded during optical coherence tomography (OCT) as a marker of neural network dysfunction in multiple sclerosis (MS), which could be used to monitor disease progression or response to treatment. Methods: A total of 16 MS patients and 26 normal subjects underwent 30 seconds of scanning laser ophthalmoscope (SLO)-based eye tracking during OCT scanning of retinal layer thickness. Study groups consisted of normal eyes, MS eyes without prior optic neuritis (MS wo ON), and MS eyes with prior optic neuritis (MS + ON)...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340631/a-better-understanding-of-ambulance-personnel-s-attitude-towards-real-time-resuscitation-feedback
#11
Peter Brinkrolf, Roman Lukas, Ulf Harding, Sebastian Thies, Joachim Gerss, Hugo Van Aken, Hans Lemke, Udo Schniedermeier, Andreas Bohn
Objective: High-quality chest compressions during cardiopulmonary resuscitation (CPR) play a significant role in surviving cardiac arrest. Chest-compression quality can be measured and corrected by real-time CPR feedback devices, which are not yet commonly used. This article looks at the acceptance of such systems in comparison of equipped and unequipped personnel. Design: Two groups of emergency medical services' (EMS) personnel were interviewed using standardized questionnaires...
January 11, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29339599/full-scale-performance-of-selected-starch-based-biodegradable-polymers-in-sludge-dewatering-and-recommendation-for-applications
#12
Kuangxin Zhou, Johan Stüber, Rabea-Luisa Schubert, Christian Kabbe, Matthias Barjenbruch
Agricultural reuse of dewatered sludge is a valid route for sludge valorization for small and mid-size wastewater treatment plants (WWTPs) due to the direct utilization of nutrients. A more stringent of German fertilizer ordinance requires the degradation of 20% of the synthetic additives like polymeric substance within two years, which came into force on 1 January 2017. This study assessed the use of starch-based polymers for full-scale dewatering of municipal sewage sludge. The laboratory-scale and pilot-scale trials paved the way for full-scale trials at three WWTPs in Germany...
January 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29338877/german-travelers-preferences-for-travel-vaccines-assessed-by-a-discrete-choice-experiment
#13
Christine Poulos, Desmond Curran, Anastassia Anastassopoulou, Laurence De Moerlooze
BACKGROUND: Many travelers to regions with endemic infectious diseases do not follow health authorities' recommendations regarding vaccination against vaccine-preventable infectious diseases, before traveling. The determinants of individual travelers' decisions to vaccinate before traveling are largely unknown. This study aimed to provide this information using a discrete choice experiment (DCE) administered to four types of German travelers: (1) business travelers; (2) travelers visiting friends and relatives (VFR); (3) leisure travelers; and (4) backpackers...
January 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29338744/new-insights-in-the-relative-radiobiological-effectiveness-of-proton-irradiation
#14
REVIEW
K Ilicic, S E Combs, T E Schmid
BACKGROUND: Proton radiotherapy is a form of charged particle therapy that is preferentially applied for the treatment of tumors positioned near to critical structures due to their physical characteristics, showing an inverted depth-dose profile. The sparing of normal tissue has additional advantages in the treatment of pediatric patients, in whom the risk of secondary cancers and late morbidity is significantly higher. Up to date, a fixed relative biological effectiveness (RBE) of 1...
January 16, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29338560/scientists-instruments-and-even-brains-in-transfer-german-spanish-postwar-networks-and-the-construction-of-the-neuroendocrine-system-1952-1960
#15
Raúl Velasco Morgado
This article presents the process of relocation of hegemonies and "center-periphery" dynamics in neuroanatomy after World War II through the study of the links between the Spanish anatomical school of José Escolar García and some German institutions. We have analyzed their works on the morphology of the neuroendocrine system as a case study, showing how the first contacts of the Spaniards with the United States started a material transfer process between centers on both sides of the Atlantic Ocean through the mediation-and adaptation-of the periphery...
January 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29338555/positive-neighborhood-norms-buffer-ethnic-diversity-effects-on-neighborhood-dissatisfaction-perceived-neighborhood-disadvantage-and-moving-intentions
#16
Jasper Van Assche, Frank Asbrock, Arne Roets, Mathias Kauff
Positive neighborhood norms, such as strong local networks, are critical to people's satisfaction with, perceived disadvantage of, and intentions to stay in their neighborhood. At the same time, local ethnic diversity is said to be detrimental for these community outcomes. Integrating both frameworks, we tested whether the negative consequences of diversity occur even when perceived social norms are positive. Study 1 ( N = 1,760 German adults) showed that perceptions of positive neighborhood norms buffered against the effects of perceived diversity on moving intentions via neighborhood satisfaction and perceived neighborhood disadvantage...
January 1, 2018: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29337605/education-and-health-across-lives-and-cohorts-a-study-of-cumulative-dis-advantage-and-its-rising-importance-in-germany
#17
Liliya Leopold, Thomas Leopold
Research from the United States has supported two hypotheses. First, educational gaps in health widen with age-the cumulative (dis)advantage hypothesis. Second, this relationship has intensified across cohorts-the rising importance hypothesis. In this article, we used 23 waves of panel data (Socio-Economic Panel Study, 1992-2014) to examine both hypotheses in the German context. We considered individual and contextual influences on the association between education and health, and we assessed gender differences in health trajectories over the life course (ages 23 to 84) and across cohorts (born between 1930 and 1969)...
January 1, 2018: Journal of Health and Social Behavior
https://www.readbyqxmd.com/read/29337444/-fumarates-far-more-than-a-dietary-supplement
#18
Wolf-Henning Boehncke, Nicolo Costantino Brembilla
Fumaric acid has an important role in the citric acid cycle. Its esters were first used by a German chemist to treat his own psoriasis, hypothesizing that the disease may be related to disturbances in this very cycle. Meanwhile, the mechanisms underlying its anti-inflammatory efficacy are much better understood. A monosubstance derived from the mix of esters used originally is now being authorized for treating multiple sclerosis, and in 2017 dimethylfumaric acid ester became a globally available option to treat psoriasis...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29336934/determination-of-recombination-and-polarity-correction-factors-ks-and-kp-for-small-cylindrical-ionization-chambers-ptw-31021-and-ptw-31022-in-pulsed-filtered-and-unfiltered-beams
#19
Gregor Bruggmoser, Rainer Saum, Rafael Kranzer
The aim of this technical communication is to provide correction factors for recombination and polarity effect for two new ionization chambers PTW PinPoint 3D (type 31022) and PTW Semiflex 3D (type 31021). The correction factors provided are for the (based on the) German DIN 6800-2 dosimetry protocol and the AAPM TG51 protocol. The measurements were made in filtered and unfiltered high-energy photon beams in a water equivalent phantom at maximum depth of the PDD and a field size on the surface of 10cm×10cm...
January 11, 2018: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29336730/motor-and-visual-spatial-cognition-development-in-primary-school-aged-children-in-cameroon-and-germany
#20
Petra Jansen, Jennifer Lehmann, Christoph Tafelmeier
It was the main goal of this study to investigate the motor and visual-spatial development in primary school-aged children in Cameroon and Germany. Thirty-four children from each country completed a motor test and a mental rotation test. It was found that children in Cameroon showed a better motor ability (better overall gross motor score and also on most single items) than children in Germany did. This can be explained by the early motor stimulation in infancy in Cameroon. Concerning mental rotation performance, Cameroonian children perform below chance level...
January 16, 2018: Journal of Genetic Psychology
keyword
keyword
51430
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"