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https://www.readbyqxmd.com/read/28731126/mir%C3%A2-132-in-atrial-fibrillation-directly-targets-connective-tissue-growth-factor
#1
Gang Qiao, Dongsheng Xia, Zhaoyun Cheng, Guobao Zhang
Atrial fibrillation (AF) is the most frequently occurring, persistent cardiac arrhythmia, and the hallmark of AF‑dependent structural remodeling is atrial fibrosis. Connective tissue growth factor (CTGF) is important in the process of fibrosis. The association between miRNA and CTGF in AF‑dependent fibrosis remains to be elucidated. The present study aimed to determine if microRNA (miR)‑132 was able to regulate CTGF with an anti‑fibrotic effect in AF. A total of ten dogs or patients were assigned to control (n=4) and AF groups (n=6)...
July 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28730519/left-atrial-appendage-aneurysm-presenting-with-chronic-cough
#2
M Toufan, L Pourafkari, A Afrasiabi, M Sohrabi, N D Nader
No abstract text is available yet for this article.
July 20, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28725325/left-atrial-appendage-volume-and-plasma-docosahexaenoic-acid-levels-are-associated-with-atrial-fibrillation-recurrence-after-catheter-ablation
#3
Tomoyuki Shiozawa, Kazunori Shimada, Gaku Sekita, Hidemori Hayashi, Haruna Tabuchi, Seiji Miura, Shinichiro Fujimoto, Tomoyasu Kadoguchi, Shohei Ouchi, Tatsuro Aikawa, Hamad Al Shahi, Shuhei Takahashi, Tetsuro Miyazaki, Masataka Sumiyoshi, Yuji Nakazato, Hiroyuki Daida
BACKGROUND: Risk factors for atrial fibrillation (AF) recurrence in patients who have undergone AF catheter ablation have not been fully clarified. The objective of this study was to assess whether the left atrium (LA) and LA appendage (LAA) volumes, and cardio-metabolic markers such as polyunsaturated fatty acids (PUFAs) levels were associated with AF recurrence. METHODS: Seventy-seven consecutive patients with AF (mean age, 59 ± 8 years; male, 81%; paroxysmal AF, 64%) undergoing catheter ablation were enrolled...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28721464/unexpected-ubx-expression-in-the-maxilliped-of-the-mystacocarid-crustacean-derocheilocharis-remanei-evidence-for-a-different-way-of-making-a-maxilliped
#4
Martin Fritsch, Stefan Richter
In terms of morphology, crustacean maxillipeds are hybrid appendages. They arise in anterior thoracic segments and display characteristics of both locomotory (thoracic) and feeding (gnathal) appendages. Maxillipeds are functionally integrated with the anterior gnathal appendages. Hox gene expression patterns and immunolabeling with the FP6.87 antibody, which detects conserved epitopes of UBX and ABD-A proteins, reveal that maxillipeds are consistently associated with a shift in the expression of the homeotic gene Ubx...
July 18, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28717286/histological-changes-in-nasolabial-cutaneous-flaps-employed-in-intraoral-reconstruction
#5
Lazaridou Maria, Dimitrakopoulos Ioannis, Vaxtsevanos Konstantinos, Iordanidis Fotis, Antoniades Konstantinos
INTRODUCTION: Nasolabial cutaneous flaps have been routinely used to reconstruct intraoral defects. The purpose of this study was to study histological changes that may occur in the skin flap as a result of its exposure to a new environment. PATIENTS AND METHODS: Thirteen patients took part in this study. Fusiform tissue specimens were obtained from the intraoral cutaneous portion of the flap. Biopsy specimens were also taken from the skin of nasolabial region and from the buccal mucosa to serve as control...
September 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28714617/-left-atrial-appendage-occlusion-for-atrial-fibrillation
#6
Marco Roberto, Amir-Ali Fassa, Edoardo De Benedetti
Embolic stroke is the most dangerous complication of atrial fibrillation (AF). Oral anticoagulation represents the treatment of choice for thromboembolic (TE) prophylaxis in patients with a CHADS2VASc score ≥ 1 but is associated with a significant increase in haemorrhagic events. Almost 90 % of thrombi originate in the left atrial appendage. Registries have shown that percutaneous occlusion of this appendage reduces embolic risk and may be considered for TE prophylaxis in patients with a high TE (CHADS2VASc score ≥ 2) and haemorrhagic (HAS-BLED score ≥ 3) risk...
March 1, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28713823/intracardiac-hemostasis-and-fibrinolysis-parameters-in-patients-with-atrial-fibrillation
#7
Noémi Klára Tóth, Zoltán Csanádi, Orsolya Hajas, Alexandra Kiss, Edina Nagy-Baló, Kitti Bernadett Kovács, Ferenc Sarkady, László Muszbek, Zsuzsanna Bereczky, László Csiba, Zsuzsa Bagoly
AIMS: To identify intracardiac hemostasis or fibrinolysis abnormalities, which are associated with atrial fibrillation (AF) and increase the risk of thromboembolism. PATIENTS AND METHODS: Patient group consisted of 24 patients with AF and control group included 14 individuals with other supraventricular tachycardia undergoing transcatheter radiofrequency ablation. Blood samples were drawn from the femoral vein (FV), left atrium (LA), and left atrial appendage (LAA) before the ablation procedure...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28709396/rapid-diversification-of-homothorax-expression-patterns-after-gene-duplication-in-spiders
#8
Natascha Turetzek, Sara Khadjeh, Christoph Schomburg, Nikola-Michael Prpic
BACKGROUND: Gene duplications provide genetic material for the evolution of new morphological and physiological features. One copy can preserve the original gene functions while the second copy may evolve new functions (neofunctionalisation). Gene duplications may thus provide new genes involved in evolutionary novelties. RESULTS: We have studied the duplicated homeobox gene homothorax (hth) in the spider species Parasteatoda tepidariorum and Pholcus phalangioides and have compared these data with previously published data from additional spider species...
July 14, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28706589/catheter-ablation-of-atrial-fibrillation-facilitated-by-preprocedural-three-dimensional-transesophageal-echocardiography-long-term-outcome
#9
Klaus Kettering, Felix Gramley, Stephan von Bardeleben
AIM: To evaluate the long-term outcome of catheter ablation of atrial fibrillation (AF) facilitated by preprocedural three-dimensional (3-D) transesophageal echocardiography. METHODS: In 50 patients, 3D transesophageal echocardiography (3D TEE) was performed immediately prior to an ablation procedure (paroxysmal AF: 30 patients, persistent AF: 20 patients). The images were available throughout the ablation procedure. Two different ablation strategies were used. In most of the patients with paroxysmal AF, the cryoablation technique was used (Arctic Front Balloon, CryoCath Technologies/Medtronic; group A2)...
June 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28705104/asymptomatic-giant-right-atrial-appendage-aneurysm-a-7-year-follow-up
#10
Martin Chaumont, Aurélia David-Cojocariu, Kaies Akkari, Dominique Schulze, Philippe Unger
No abstract text is available yet for this article.
July 14, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28698625/ectodysplasin-target-gene-fgf20-regulates-mammary-bud-growth-and-ductal-invasion-and-branching-during-puberty
#11
Teresa Elo, Päivi H Lindfors, Qiang Lan, Maria Voutilainen, Ewelina Trela, Claes Ohlsson, Sung-Ho Huh, David M Ornitz, Matti Poutanen, Beatrice A Howard, Marja L Mikkola
Mammary gland development begins with the appearance of epithelial placodes that invaginate, sprout, and branch to form small arborized trees by birth. The second phase of ductal growth and branching is driven by the highly invasive structures called terminal end buds (TEBs) that form at ductal tips at the onset of puberty. Ectodysplasin (Eda), a tumor necrosis factor-like ligand, is essential for the development of skin appendages including the breast. In mice, Eda regulates mammary placode formation and branching morphogenesis, but the underlying molecular mechanisms are poorly understood...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28694803/comparative-genomics-identifies-a-novel-conserved-protein-hpat-in-proteobacterial-type-iii-secretion-systems-that-do-not-possess-the-putative-translocon-protein-hrpf
#12
Céline Pesce, Jonathan M Jacobs, Edwige Berthelot, Marion Perret, Taca Vancheva, Claude Bragard, Ralf Koebnik
Xanthomonas translucens is the causal agent of bacterial leaf streak, the most common bacterial disease of wheat and barley. To cause disease, most xanthomonads depend on a highly conserved type III secretion system, which translocates type III effectors into host plant cells. Mutagenesis of the conserved type III secretion gene hrcT confirmed that the X. translucens type III secretion system is required to cause disease on the host plant barley and to trigger a non-host hypersensitive response (HR) in pepper leaves...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28691914/residual-leaks-following-percutaneous-left-atrial-appendage-occlusion-assessment-and-management-implications
#13
Claire E Raphael, Paul A Friedman, Jacqueline Saw, Sorin V Pislaru, Thomas M Munger, David R Holmes
Left atrial appendage (LAA) closure for stroke prevention in the setting of non valvular atrial fibrillation is an alternative to oral anticoagulation in patients with increased bleeding risk. It allows similar reduction in thromboembolic events, in particular stroke, compared to warfarin. A common clinical dilemma is the management of patients with peri-device leak after LAA occlusion. This has been documented in both percutaneous as well as with surgical approaches. The specific definitions of leak severity, and the longer term clinical implications are poorly understood...
July 11, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28690086/combined-mitraclip-implantation-and-left-atrial-appendage-occlusion-because-it-s-there-revisited
#14
Duarte Cacela
No abstract text is available yet for this article.
July 6, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28682604/extending-the-excitation-wavelength-of-potential-photosensitizers-via-appendage-of-a-kinetically-stable-terbium-iii-macrocyclic-complex-for-applications-in-photodynamic-therapy
#15
Phuc Ung, Michèle Clerc, Huaiyi Huang, Kangqiang Qiu, Hui Chao, Michael Seitz, Ben Boyd, Bim Graham, Gilles Gasser
The development of viable photodynamic therapy protocols is often hindered by photosensitizers that require high-energy UV irradiation that has limited potential for clinical use due to its low tissue penetration. Herein, we report a strategy for extending the excitation wavelength of potential photosensitizers via the covalent attachment of a terbium(III)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetate complex (DO3A-Tb). The method was systematically demonstrated with a series of polycyclic aromatic hydrocarbons (naphthalene, phenanthrene, anthracene, pyrene, and fluoranthene) to prepare six new complexes (Tb1-Tb6) with bathochromic shifts that extended into the visible region...
July 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28680466/atrial-fibrillation-with-a-structurally-normal-heart-in-pregnancy-an-international-survey-on-current-practice
#16
Annabelle Cumyn, Nadine Sauvé, Évelyne Rey
BACKGROUND: Little evidence exists for the optimal management of atrial fibrillation with a structurally normal heart in pregnancy. METHODS: A survey was sent to members of two associations to obtain input on optimal management of atrial fibrillation in pregnancy. The survey presented four cases with respect to (1) baseline investigations; (2) rate versus rhythm control; (3) chemical versus electrical cardioversion; and (4) anticoagulation. RESULTS: Sixty-one responders from 11 countries participated...
June 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/28679318/oscillating-left-atrial-appendage-in-a-massive-pericardial-effusion-due-to-severe-paravalvular-leakage-after-mitral-valve-replacement
#17
Mahmut Yesin, Macit Kalçık, Metin Çağdaş, Süleyman Karakoyun, Emrah Bayam, Mehmet Özkan
No abstract text is available yet for this article.
July 6, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28675629/long-term-follow-up-after-left-atrial-appendage-occlusion-with-comparison-of-transesophageal-echocardiography-vs-computed-tomography-to-guide-medical-therapy-and-data-about-post-closure-cardioversion
#18
Benjamin Berte, Christine Attenhofer Jost, Dominik Maurer, Anja Fäh-Gunz, Xavier Pillois, Barbara Naegeli, Monica Pfyffer, Gabor Sütsch, Christoph Scharf
AIMS: The use of left atrial appendage (LAA)-occluders in atrial fibrillation is increasing. There are few data on the comparison between transesophageal echocardiography (TEE) and computed tomography (MDCT) assessing peridevice-flow and outcome of electrical cardioversion (ECV) in these patients. METHODS AND RESULTS: Single-center prospective registry from 2009 to 2015 including all LAA-occluders to analyze success and complications during implantation and follow-up...
July 4, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28675372/boundary-dpp-promotes-growth-of-medial-and-lateral-regions-of-the-drosophila-wing
#19
Lara Barrio, Marco Milan
The gradient of Decapentaplegic (Dpp) in the Drosophila wing has served as a paradigm to characterize the role of morphogens in regulating patterning. However, the role of this gradient in regulating tissue size is a topic of intense debate as proliferative growth is homogenous. Here we combined the Gal4/UAS system and a temperature-sensitive Gal80 molecule to induce RNAi-mediated depletion of dpp and characterise the spatial and temporal requirement of Dpp in promoting growth. We show that Dpp emanating from the AP compartment boundary is required throughout development to promote growth by regulating cell proliferation and tissue size...
July 4, 2017: ELife
https://www.readbyqxmd.com/read/28673783/combined-mitraclip-implantation-and-left-atrial-appendage-occlusion-using-the-watchman-device-a-case-series-from-a-referral-center
#20
Ana Rita G Francisco, Eduardo Infante de Oliveira, Miguel Nobre Menezes, Pedro Carrilho Ferreira, Pedro Canas da Silva, Ângelo Nobre, Fausto J Pinto
INTRODUCTION: Patients referred for percutaneous transcatheter mitral valve repair using the MitraClip(®) system frequently have atrial fibrillation, which imposes additional challenges due to the need for oral anticoagulation. Left atrial appendage occlusion is currently regarded as a non-inferior alternative to anticoagulation in patients with non-valvular atrial fibrillation and both high thromboembolic and bleeding risk. Considering that both MitraClip implantation and left atrial appendage occlusion are percutaneous techniques that require transseptal puncture, it is technically attractive to consider their concomitant use...
June 30, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
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