Fengling Ning, Ling Du, Jiayang Li, Tiangang Wu, Jiacheng Zhou, Zihui Chen, Xuetao Hu, Yuai Zhang, Xin Luan, Hong Xin, Chunyan Yuan, Xuemei Zhang
AIMS: Ubiquitin specific peptidase 5 (USP5), a member of deubiquitinating enzymes, has garnered significant attention for its crucial role in cancer progression. This study aims to explore the role of USP5 and its potential molecular mechanisms in cholangiocarcinoma (CCA). MAIN METHODS: To explore the effect of USP5 on CCA, gain-of-function and loss-of-function assays were conducted in human CCA cell lines RBE and HCCC9810. The CCK8, colony-forming assay, EDU, flow cytometry, transwell assay and xenografts were used to assess cell proliferation, migration and tumorigenesis...
April 29, 2024: Life Sciences