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Extracellular Dermal Matrix

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https://www.readbyqxmd.com/read/28916993/periostin-in-the-pathogenesis-of-skin-diseases
#1
REVIEW
Hiroyuki Murota, Yang Lingli, Ichiro Katayama
Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. In this process, changes in the components of the extracellular matrix are required to provide an environment that facilitates tissue remodeling...
September 15, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28911799/effects-of-glucocorticoids-on-stratum-corneum-lipids-and-function-in-human-skin-a-detailed-lipidomic-analysis
#2
Mads A Røpke, Cristina Alonso, Sora Jung, Hanne Norsgaard, Claudia Richter, Maxim E Darvin, Thomas Litman, Annika Vogt, Jürgen Lademann, Ulrike Blume-Peytavi, Jan Kottner
BACKGROUND: Topical glucocorticoids (GCs) are known to induce atrophy of human skin including thinning of epidermal and dermal compartments by influencing keratinocyte proliferation and synthesis of extracellular matrix proteins. GCs are also known to reduce skin barrier integrity but little is known about the changes in lipid composition in human skin following topical administration of GCs. OBJECTIVE: This study investigated the effects of GCs on stratum corneum (SC) function and lipid profile of human skin in vivo...
August 26, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28906033/collagen-peptides-modulates-the-metabolism-of-extracellular-matrix-by-human-dermal-fibroblasts-derived-from-sun-protected-and-sun-exposed-body-sites
#3
Vivian Zague, Jonatas Bussador do Amaral, Paula Rezende Teixeira, Evandro Luis de Oliveira Niero, Camila Lauand, Glaucia Maria Machado-Santelli
Clinical data published in recent years has demonstrated positive effects of collagen hydrolysate (CH) on skin aging clinical signs. CH use as food supplement has a long history; however, few studies have addressed the underlying purpose of CH on the cellular and molecular biology of skin cells that could elucidate clinical improvement findings. Wide diversity of characteristics has been reported for dermal fibroblasts derived from different body sites and it is unknown whether collagen peptides could modulate differently cells from chronological aged and photoaged skin areas...
September 14, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28882457/characterization-of-dermal-myofibroblast-differentiation-in-pseudoxanthoma-elasticum
#4
Isabel Faust, Elfi Donhauser, Bastian Fischer, Bettina Ibold, Joachim Kuhn, Cornelius Knabbe, Doris Hendig
Pseudoxanthoma elasticum (PXE) is a rare hereditary disorder which is caused by ABCC6 (ATP-binding cassette subfamily C member 6) gene mutations. Characteristic hallmarks of PXE are progressive calcification and degradation of the elastic fibers in skin, cardiovascular system and ocular fundus. Since the underlying pathomechanisms of PXE remain unidentified, the aim of this study was to get new insights into PXE pathophysiology by characterizing dermal myofibroblast differentiation. Fibroblasts are the key cells of extracellular matrix (ECM) remodeling and, therefore, participate not only in physiological processes, such as calcification or wound healing, but also in pathologic events, such as fibrotization...
September 4, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28874184/multipotent-stromal-cells-mesenchymal-stem-cells-and-fibroblasts-combine-to-minimize-skin-hypertrophic-scarring
#5
Cecelia C Yates, Melanie Rodrigues, Austin Nuschke, Zariel I Johnson, Diana Whaley, Donna Stolz, Joseph Newsome, Alan Wells
BACKGROUND: Transplantation of mesenchymal stem cells (MSC) has been proposed to improve wound healing. However, as these cells only transiently survive in the implantation site, the mechanisms underlying this beneficial healing response are associated with restorative paracrine effects of MSC matricellular factors on resident stromal cells. However, this requires that the recipient has a robust reservoir of viable cells. Here, we examine the influence of MSCs on the behavior of cotransplanted fibroblasts, in a manner to provide augmented cellular reserve to debilitated individuals, specifically focusing on matrix remodeling following in-vivo wounding...
September 5, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28860484/biocomposite-nanofiber-matrices-to-support-ecm-remodeling-by-human-dermal-progenitors-and-enhanced-wound-closure
#6
Fraz Anjum, Natacha A Agabalyan, Holly D Sparks, Nicole L Rosin, Michael S Kallos, Jeff Biernaskie
Cell-based therapies have recently been the focus of much research to enhance skin wound healing. An important challenge will be to develop vehicles for cell delivery that promote survival and uniform distribution of cells across the wound bed. These systems should be stiff enough to facilitate handling, whilst soft enough to limit damage to newly synthesized wound tissue and minimize patient discomfort. Herein, we developed several novel modifiable nanofibre scaffolds comprised of Poly (ε-caprolactone) (PCL) and gelatin (GE)...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858391/pterocarpus-santalinus-l-regulated-ultraviolet-b-irradiation-induced-procollagen-reduction-and-matrix-metalloproteinases-expression-through-activation-of-tgf-%C3%AE-smad-and-inhibition-of-the-mapk-ap-1-pathway-in-normal-human-dermal-fibroblasts
#7
Wei Gao, Pei Lin, Eunson Hwang, Yushuai Wang, Zhengfei Yan, Hien T T Ngo, Tae-Hoo Yi
Ultraviolet light-induced reactive oxygen species (ROS) damage human skin and prematurely cause aging. A growing body of research is focusing on considering plants and plant-derived compounds as anti-photoaging therapeutic material. Pterocarpus santalinus L., as an Indian traditional medicine, possesses antidiabetic, anti-inflammatory and antioxidative effects. Here, we studied the anti-photoaging effects of ethanolic extract of P. santalinus L. heartwood (EPS) on ultraviolet radiation B (UVB)-irradiated normal human dermal fibroblasts (NHDFs)...
August 31, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28852829/pal-12-a-new-anti-aging-hexa-peptoid-inhibits-uvb-induced-photoaging-in-human-dermal-fibroblasts-and-3d-reconstructed-human-full-skin-model-keraskin-ft%C3%A2
#8
Daeun Song, Hyeonji Park, Su-Hyon Lee, Mi Jung Kim, Eun-Joo Kim, Kyung-Min Lim
Peptoids are a class of peptidomimetics whose pharmacological activities are widely investigated owing to their remarkable biological stability. However, the utilities of peptoids as cosmetic functional ingredients have not been fully explored. Here, we investigated anti-aging effects of PAL-12, a new hexa-peptoid, on UVB-induced photoaging in human dermal fibroblasts (HDFs) and a 3D reconstituted human full skin model, Keraskin-FT™. PAL-12 suppressed matrix metalloproteinase-1 (MMP-1) expression induced by UVB irradiation along with the attenuation of MMP-1 secretion as determined by ELISA assay...
August 29, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28846936/a-new-in-vitro-assay-to-test-uvr-protection-of-dermal-extracellular-matrix-components-by-a-flat-spectrum-sunscreen
#9
S A Hibbert, P Costello, C O'Connor, M Bell, C E M Griffiths, R E B Watson, M J Sherratt
The efficacy of topical sunscreens is currently assessed by crude, costly and time consuming in vivo assays. We have previously demonstrated that components of the dermal extracellular matrix (ECM), rich in UV-absorbing amino acids, are susceptible to damage by solar simulated radiation (SSR) in vitro. Here we developed an in vitro method to test the ability of sunscreens to protect fibrillin-rich microfibrils (FRM) and fibronectin, key components of the dermal ECM from UV-induced damage. Solutions of FRM or fibronectin were irradiated without protection, in the presence of a vehicle or a commercially-available flat-spectrum sunscreen...
August 16, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28842435/mesenchymal-stem-cells-correct-impaired-diabetic-wound-healing-by-decreasing-ecm-proteolysis
#10
Junwang Xu, Carlos Zgheib, Maggie Hodges, Robert C Caskey, Junyi Hu, Kenneth W Liechty
Impaired diabetic wound healing is associated with a dermal extracellular matrix protein profile favoring proteolysis; within the healing diabetic wound, this is represented by an increase in activated matrix metalloproteinase (MMPs). Treatment of diabetic wounds with mesenchymal stem cells (MSCs) has been shown to improve wound healing. Using in vitro models of fibroblast co-culture with MSCs and in vivo murine wound healing models, we tested the hypothesis that MSCs correct dysregulation of MMPs in a microRNA-29b dependent mechanism...
August 25, 2017: Physiological Genomics
https://www.readbyqxmd.com/read/28842322/integrin-%C3%AE-4%C3%AE-1-and-tlr4-cooperate-to-induce-fibrotic-gene-expression-in-response-to-fibronectin-s-eda-domain
#11
Rhiannon M Kelsh-Lasher, Anthony Ambesi, Cedya Bertram, Paula J McKeown-Longo
Alternative splicing of fibronectin increases expression of the EDA(+) isoform of fibronectin (EDA(+)Fn), a damage-associated molecular pattern (DAMP) molecule, which promotes fibro-inflammatory disease through the activation of toll-like receptors (TLR). Our studies indicate that the fibronectin EDA domain drives two waves of gene expression in human dermal fibroblasts. The first wave seen at 2 hours consisted of inflammatory genes, VCAM1 and TNF. The second wave evaluated at 24 hours was composed of the fibrosis-associated cytokines, IL-10 and IL-13, and extracellular matrix genes fibronectin and osteopontin...
August 22, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28833753/lactoferrin-induces-tropoelastin-expression-by-activating-the-lipoprotein-receptor-related-protein-1-mediated-phosphatidylinositol-3-kinase-akt-pathway-in-human-dermal-fibroblasts
#12
Mizuyuki Ryu, Asuka Nogami, Tomoya Kitakaze, Naoki Harada, Yasushi A Suzuki, Ryoichi Yamaji
Dermal fibroblasts generate the extracellular matrix component elastin, which is synthesized as tropoelastin (TE) and play a critical role in maintaining skin elasticity. Lactoferrin (Lf), an 80-kDa iron-binding glycoprotein, has biological functions such as antibacterial, antiinflammatory, and anticancer activities. We previously reported that bovine Lf increases TE mRNA expression in human dermal fibroblasts. However, it remains unclear how Lf up-regulates TE expression. Here, we investigated molecular mechanisms underlying this effect...
August 18, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28815554/severe-disruption-and-disorganization-of-dermal-collagen-fibrils-in-early-striae-gravidarum
#13
F Wang, K Calderone, T T Do, N R Smith, Y R Helfrich, T R B Johnson, S Kang, J J Voorhees, G J Fisher
BACKGROUND: Striae gravidarum (SG), or stretch marks of pregnancy, begin as erythematous streaks, and mature into hypopigmented atrophic bands. OBJECTIVES: To investigate molecular alterations that may promote atrophy of SG, we investigated dermal type I collagen fibrils, which provide human skin with support. METHODS: We obtained skin samples of recently developed, erythematous abdominal SG from pregnant women. To examine the organization of collagen fibrils, second-harmonic generation imaging was performed using multiphoton microscopy...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28814429/nintedanib-macrophage-activation-and-ameliorates-vascular-and-fibrotic-manifestations-in-the-fra2-mouse-model-of-systemic-sclerosis
#14
Jingang Huang, Christiane Maier, Yun Zhang, Alina Soare, Clara Dees, Christian Beyer, Ulrike Harre, Chih-Wei Chen, Oliver Distler, Georg Schett, Lutz Wollin, Jörg H W Distler
BACKGROUND: Nintedanib is an inhibitor targeting platelet-derived growth factor receptor, fibroblast growth factor receptor and vascular endothelial growth factor receptor tyrosine kinases that has recently been approved for the treatment of idiopathic pulmonary fibrosis. The aim of this study was to analyse the effects of nintedanib in the fos-related antigen-2 (Fra2) mouse model of systemic sclerosis (SSc). METHODS: The effects of nintedanib on pulmonary arterial hypertension with proliferation of pulmonary vascular smooth muscle cells (PVSMCs) and luminal occlusion, on microvascular disease with apoptosis of microvascular endothelial cells (MVECs) and on fibroblast activation with myofibroblast differentiation and accumulation of extracellular matrix were analysed...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28803240/impact-of-body-site-age-and-gender-on-the-collagen-elastin-index-by-noninvasive-in-vivo-vertical-two-photon-microscopy
#15
Carolin Czekalla, Karl-Heinz Schönborn, Nadine Döge, Sora Jung, Maxim E Darvin, Jürgen Lademann, Martina C Meinke
BACKGROUND/AIMS: Extrinsic and intrinsic skin aging is subject to constant remodeling and degradation processes, primarily in components of the extracellular matrix. While collagen fibers thin out during the aging process, the amorphous elastin fibers accumulate. These are essential formative components of the dermis. So far, these processes have been detected in vertical histological sections of invasive biopsies and recently in noninvasive horizontal scans. METHODS: In this pilot study, a modified noninvasive 2-photon microscope was applied to measure the collagen/elastin index of skin in vivo...
2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28800110/response-of-dermal-fibroblasts-to-biochemical-and-physical-cues-in-aligned-polycaprolactone-silk-fibroin-nanofiber-scaffolds-for-application-in-tendon-tissue-engineering
#16
Chih-Hao Chen, Shih-Hsien Chen, Chang-Yi Kuo, Meng-Lun Li, Jyh-Ping Chen
Silk fibroin (SF) and fiber alignment were introduced into polycaprolactone (PCL)-based electrospun nanofibers as chemical and physical cues for tendon tissue engineering applications. The physicochemical properties of random PCL (RP) nanofibers, random PCL/SF (RPSF) nanofibers and aligned PCL/SF (APSF) nanofibers were characterized for fiber orientation and SF blending effects. An in vitro cell culture with rabbit dermal fibroblasts (RDFBs) on nanofibers indicated that SF promotes cell proliferation to a higher extent than fiber alignment...
August 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28795878/effects-of-prisma%C3%A2-skin-dermal-regeneration-device-containing-glycosaminoglycans-on-human-keratinocytes-and-fibroblasts
#17
Raffaella Belvedere, Valentina Bizzarro, Luca Parente, Francesco Petrella, Antonello Petrella
Prisma® Skin is a new pharmaceutical device developed by Mediolanum Farmaceutici S.p.a. It includes alginates, hyaluronic acid and mainly mesoglycan. The latter is a natural glycosaminoglycan preparation containing chondroitin sulfate, dermatan sulfate, heparan sulfate and heparin and it is used in the treatment of vascular disease. Glycosaminoglycans may contribute to the re-epithelialization in the skin wound healing, as components of the extracellular matrix. Here we describe, for the first time, the effects of Prisma® Skin in in vitro cultures of adult epidermal keratinocytes and dermal fibroblasts...
August 10, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28771114/beneficial-effect-of-aligned-nanofiber-scaffolds-with-electrical-conductivity-for-the-directional-guide-of-cells
#18
Bon Kang Gu, Sang Jun Park, Chun-Ho Kim
Conducting polymer-based scaffolds receive biological and electrical signals from the extracellular matrix (ECM) or peripheral cells, thereby promoting cell growth and differentiation. Chitin, a natural polymer, is widely used as a scaffold because it is biocompatible, biodegradable, and nontoxic. In this study, we used an electrospinning technique to fabricate conductive scaffolds from aligned chitin/polyaniline (Chi/PANi) nanofibers for the directional guidance of cells. Pure chitin and random and aligned Chi/PANi nanofiber scaffolds were characterized using field emission scanning electron microscope (FE-SEM) and by assessing wettability, mechanical properties, and electrical conductivity...
August 3, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28770671/marine-algae-as-attractive-source-to-skin-care
#19
Jean-Yves Berthon, Rachida Nachat-Kappes, Mathieu Bey, Jean-Paul Cadoret, Isabelle Renimel, Edith Filaire
As the largest organ in the human body, the skin has multiple functions of which one of the most important is the protection against various harmful stressors. The keratinised stratified epidermis and an underlying thick layer of collagen-rich dermal connective tissues are important components of the skin. The environmental stressors such as ultraviolet radiation (UVR) and pollution increase the levels of reactive oxygen species (ROS), contributing to clinical manifestations such as wrinkle formation and skin aging...
June 2017: Free Radical Research
https://www.readbyqxmd.com/read/28760620/microcontact-printing-of-polydopamine-on-thermally-expandable-hydrogels-for-controlled-cell-adhesion-and-delivery-of-geometrically-defined-microtissues
#20
Yu Bin Lee, Se-Jeong Kim, Eum Mi Kim, Hayeon Byun, Hyung-Kwan Chang, Jungyul Park, Yu Suk Choi, Heungsoo Shin
Scaffold-free harvest of microtissue with a defined structure has received a great deal of interest in cell-based assay and regenerative medicine. In this study, we developed thermally expandable hydrogels with spatially controlled cell adhesive patterns for rapid harvest of geometrically controlled microtissue. We patterned polydopamine (PD) on to the hydrogel via microcontact printing (μCP), in linear shapes with widths of 50, 100 and 200μm. The hydrogels facilitated formation of spatially controlled strip-like microtissue of human dermal fibroblasts (HDFBs)...
July 28, 2017: Acta Biomaterialia
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