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https://www.readbyqxmd.com/read/28109631/american-brachytherapy-task-group-report-a-pooled-analysis-of-clinical-outcomes-for-high-dose-rate-brachytherapy-for-cervical-cancer
#1
REVIEW
Jyoti Mayadev, Akila Viswanathan, Yu Liu, Chin-Shang Li, Kevin Albuquerque, Antonio L Damato, Sushil Beriwal, Beth Erickson
PURPOSE: Advanced imaging used in combination with brachytherapy (BT) has revolutionized the treatment of patients with cervical cancer. We present a comprehensive review of the literature for definitive radiation with high-dose-rate (HDR) BT. In addition, we investigate potential outcome improvement with image-based brachytherapy (IBBT) compared to studies using traditional Point A dosing. This review extensively investigates acute and late toxicities. METHODS AND MATERIALS: This study reviews the literature from 2000 to 2015 with an emphasis on modern approaches including concurrent chemotherapy (chemoRT), radiation, and HDR BT and IBBT...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/28108550/cardiac-resynchronization-therapy-in-adults-with-congenital-heart-disease
#2
Zeliha Koyak, Joris R de Groot, Ahmed Krimly, Tara M Mackay, Berto J Bouma, Candice K Silversides, Erwin N Oechslin, Ulas Hoke, Lieselot van Erven, Werner Budts, Isabelle C Van Gelder, Barbara J M Mulder, Louise Harris
AIMS: In adults with congenital heart disease (CHD) heart failure is one of the leading causes of morbidity and mortality but experience with and reported outcome of cardiac resynchronization therapy (CRT) is limited. We investigated the efficacy of CRT in adults with CHD. METHODS AND RESULTS: This was a retrospective study including 48 adults with CHD who received CRT since 2003 in four tertiary referral centres. Responders were defined as patients who showed improvement in NYHA functional class and/or systemic ventricular ejection fraction by at least one category...
January 20, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28106889/the-incidence-and-risk-factors-for-the-development-of-vitreomacular-interface-abnormality-in-diabetic-macular-edema-treated-with-intravitreal-injection-of-anti-vegf
#3
C-K Chang, C-K Cheng, C-H Peng
PurposeTo report the incidence and associated factors for the development of vitreomacular interface abnormality (VMIA) in patients with diabetic macular edema (DME) who received intravitreal injection (IVI) of anti-VEGF (Bevacizumab and Ranibizumab) treatment.MethodsA retrospective observational study. Patients with DME followed at least 6 months were reviewed. Baseline best-corrected visual acuity (BCVA), central retinal thickness (CRT) and final BCVA, CRT in eyes with and without VMIA were compared. Multiple logistic regression was also used to investigate the risk factors of VMIA formation in patients with DME treated by anti-VEGF...
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28106887/report-of-12-months-efficacy-and-safety-of-intravitreal-fluocinalone-acetonide-implant-for-the-treatment-of-chronic-diabetic-macular-oedema-a-real-world-result-in-the-united-kingdom
#4
F Alfaqawi, P L Lip, S Elsherbiny, R Chavan, A Mitra, B Mushtaq
: PurposeTo report the 12-months visual and anatomical outcomes of chronic diabetic macular oedema (DMO) treated with ILUVIEN in a real-world clinical practice in a single tertiary referral centre.MethodRetrospective data collection and analysis of consecutive 28 eyes of 23 diabetic patients received ILUVIEN implant for refractory DMO. Standard assessment included visual acuity (VA), central retinal thickness (CRT), slit-lamp biomicroscopy, and Goldmann tonometry for intraocular pressure (IOP) at 1, 6, and 12 months...
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28106543/expression-and-significance-of-calreticulin-in-human-osteosarcoma
#5
Xu-Hua Zhang, Yue Zhang, Wen-Peng Xie, De-Sheng Sun, Yong-Kui Zhang, Yan-Ke Hao, Guo-Qing Tan
BACKGROUND: As one of the endoplasmic reticulum proteins, Calreticulin (CRT) plays a significant role in the body, and it has been used by many researchers as a target for anti-tumor therapy. OBJECTIVE: The main purpose of the present study was to study expression of CRT of osteosarcoma cells, and analyze the distinctions between normal and tumor tissues, pre- and post-chemotherapy patients, and metastatic and non-metastatic tumors in respect to this expression...
January 13, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28105886/interobserver-delineation-uncertainty-in-involved-node-radiation-therapy-inrt-for-early-stage-hodgkin-lymphoma-on-behalf-of-the-radiotherapy-committee-of-the-eortc-lymphoma-group
#6
Marianne C Aznar, Theodore Girinsky, Anne Kiil Berthelsen, Berthe Aleman, Max Beijert, Martin Hutchings, Yolande Lievens, Paul Meijnders, Peter Meidahl Petersen, Deborah Schut, Maja V Maraldo, Richard van der Maazen, Lena Specht
BACKGROUND AND PURPOSE: In early-stage classical Hodgkin lymphoma (HL) the target volume nowadays consists of the volume of the originally involved nodes. Delineation of this volume on a post-chemotherapy CT-scan is challenging. We report on the interobserver variability in target volume definition and its impact on resulting treatment plans. MATERIALS AND METHODS: Two representative cases were selected (1: male, stage IB, localization: left axilla; 2: female, stage IIB, localizations: mediastinum and bilateral neck)...
January 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28104669/sex-specific-outcomes-with-addition-of-defibrillation-to-resynchronisation-therapy-in-patients-with-heart-failure
#7
Sérgio Barra, Rui Providência, Rudolf Duehmke, Serge Boveda, Eloi Marijon, Christian Reitan, Rasmus Borgquist, Didier Klug, Pascal Defaye, Nicolas Sadoul, Jean-Claude Deharo, Iannish Sadien, Kiran Patel, Khang-Li Looi, David Begley, Anthony W Chow, Jean-Yves Le Heuzey, Sharad Agarwal
OBJECTIVE: Among primary prevention patients with heart failure receiving cardiac resynchronisation therapy (CRT), the impact of additional implantable cardioverter defibrillator (ICD) treatment on outcomes and its interaction with sex remains uncertain. We aim to assess whether the addition of the ICD functionality to CRT devices offers a more pronounced survival benefit in men compared with women, as previous research has suggested. METHODS: Observational multicentre cohort study of 5307 consecutive patients with ischaemic or non-ischaemic dilated cardiomyopathy and no history of sustained ventricular arrhythmias having CRT implantation with (cardiac resynchronisation therapy defibrillator (CRT-D), n=4037) or without (cardiac resynchronisation therapy pacemaker (CRT-P), n=1270) defibrillator functionality...
January 19, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28104482/device-pacing-diagnostics-overestimate-effective-crt-pacing-results-of-the-holter-for-efficacy-analysis-of-crt-study-ol%C3%A3-crt-study
#8
Antonio Hernández-Madrid, Domenico Facchin, Ruth Nicholson Klepfer, Subham Ghosh, Roberto Matía, Javier Moreno, Alessandro Locatelli
BACKGROUND: A high percentage of bi-ventricular (BiV) or left ventricular (LV) pacing in CRT devices has been associated with superior clinical outcomes. However, the percent ventricular (V) pacing reported by CRT devices simply indicates the number of paces the device has delivered, not the proportion of pacing that has captured the LV effectively. OBJECTIVE: A beat-by-beat evaluation of effective pacing would provide a more accurate evaluation of CRT delivery...
January 16, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28104154/cost-analysis-of-transplantation-in-japan-performed-with-the-use-of-the-national-database
#9
T Kitazawa, K Matsumoto, S Fujita, K Seto, T Hasegawa
BACKGROUND: When assessing the cost of transplants in Japan, earlier studies have been limited to case series that investigated inpatient cost alone. Few studies have evaluated total cost, which includes inpatient, outpatient, and pharmaceutical costs, or compared costs before and after transplantation. Using the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB), we investigated the total cost of major transplantation and contributing factors. METHODS: We analyzed the cost and complications of patients who underwent a cadaveric renal transplantation (CRT), living renal transplantation (LRT), living-donor liver transplantation (LDLT), allogeneic bone marrow transplantation, autologous bone marrow transplantation, allogeneic peripheral blood stem cell transplantation, or autologous peripheral blood stem cell transplantation (auto-PBSCT) from April 2009 to March 2010...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28102456/efficacy-and-safety-of-a-fixed-bimonthly-ranibizumab-treatment-regimen-in-eyes-with-neovascular-age-related-macular-degeneration-results-from-the-rabimo-trial
#10
Nicolas Feltgen, Thomas Bertelmann, Mirko Bretag, Sebastian Pfeiffer, Reinhard Hilgers, Josep Callizo, Lena Goldammer, Sebastian Bemme, Hans Hoerauf
PURPOSE: To evaluate prospectively the efficacy and safety of a fixed bimonthly ranibizumab treatment regimen (RABIMO) in eyes with neovascular age-related macular degeneration (nAMD) and to compare these results with a pro re nata (PRN) treatment scheme. METHODS: This was a 12-month, phase IV, single center, randomised, non-inferiority study. Following three initial monthly injections, patients were randomised to receive either ranibizumab bimonthly (RABIMO group) or ranibizumab PRN (PRN group) (n = 20 each)...
January 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28100902/prognostic-role-of-neutrophil-to-lymphocyte-ratio-in-locally-advanced-rectal-cancer-treated-with-neoadjuvant-chemoradiotherapy
#11
Jinwen Shen, Yuan Zhu, Wei Wu, Lingnan Zhang, Haixing Ju, Yongtian Fan, Yuping Zhu, Jialin Luo, Peng Liu, Ning Zhou, Ke Lu, Na Zhang, Dechuan Li, Luying Liu
BACKGROUND Increasing evidence suggests that cancer-associated inflammation is associated with poorer outcomes. The neutrophil-to-lymphocyte ratio (NLR), considered as a systemic inflammation marker, is thought to predict prognoses in colorectal cancer. In this study, we explored the association between the NLR and prognoses following neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). MATERIAL AND METHODS From February 2002 to December 2012, a group of 202 patients diagnosed with LARC and receiving neoadjuvant CRT followed by radical surgery was included in our retrospective study...
January 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28099957/results-of-surgical-salvage-treatment-for-anal-canal-cancer-a-retrospective-analysis-with-overview-of-the-literature
#12
Benedetta Pesi, Stefano Scaringi, Carmela Di Martino, Giacomo Batignani, Francesco Giudici, Damiano Bisogni, Francesco Tonelli, Paolo Bechi
BACKGROUND AND AIM: Chemoradiotherapy (CRT) is the gold standard treatment for anal cancer, which permits the maintenance of the anal function. However, about 30-40% of patients develop local disease progression, for which surgery represents a good salvage therapy. The aim of this study is to evaluate survival and morbidity rate in patients who undergo salvage surgery in our single institution, with an overview of the literature. METHODS: A retrospective study was carried out on patients who underwent surgical treatment of anal canal cancer after failure of CRT...
January 19, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28097311/association-of-lymphovascular-space-invasion-with-locoregional-failure-and-survival-in-patients-with-node-negative-oral-tongue-cancers
#13
Richard J Cassidy, Jeffrey M Switchenko, Naresh Jegadeesh, Mutlay Sayan, Matthew J Ferris, Bree R Eaton, Kristin A Higgins, Jeffrey T Wadsworth, Kelly R Magliocca, Nabil F Saba, Jonathan J Beitler
Importance: The indications for adjuvant therapy in resected oral tongue cancers are based on both clinical and pathological factors, with clear evidence for adjuvant radiation in patients with pathologically positive neck lymph nodes, positive margins, and extracapsular extension, but the data for patients with no nodal disease are sparse. Objective: To investigate determinants of failure and survival in patients with node-negative oral tongue cancer. Design, Setting, and Participants: Medical records for patients with oral tongue cancer treated with definitive surgery from 2003 to 2013 were reviewed...
January 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28096551/the-natural-evolution-of-idiophatic-epimacular-membrane
#14
Libor Hejsek, Alexandr Stepanov, Alena Dohnalova, Tereza Rehakova, Nada Jiraskova
BACKGROUND AND AIMS: Epiretinal membrane (ERM) refers to a semi-translucent tissue layer found on the inner surface of the retina especially in older people. Surgical treatment remains controversial, optimal timing for such treatment is difficult to determine and data on the natural evolution of this disorder are limited. In this study we evaluated the natural course of idiopathic epimacular membrane in 49 patients (53 eyes). MATERIALS AND METHODS: Retrospective evaluation of a group of 49 patients (53 eyes) with idiopathic epimacular membrane confirmed by biomicroscopy, photography and optical coherence tomography (OCT)...
January 13, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28096288/mid-regional-pro-atrial-natriuretic-peptide-to-predict-clinical-course-in-heart-failure-patients-undergoing-cardiac-resynchronization-therapy
#15
Mattia Arrigo, Quynh A Truong, Jackie Szymonifka, Mercedes Rivas-Lasarte, Heli Tolppanen, Malha Sadoune, Etienne Gayat, Alain Cohen-Solal, Frank Ruschitzka, James L Januzzi, Jagmeet P Singh, Alexandre Mebazaa
AIMS: Cardiac resynchronization therapy (CRT) induces reverse cardiac remodelling in heart failure (HF), but many patients receiving CRT remain non-responders. This study assessed the role of amino-terminal-pro-B-type natriuretic peptide (NT-proBNP), mid-regional-pro-atrial natriuretic peptide (MR-proANP), and mid-regional-pro-adrenomedullin (MR-proADM) at the time of device implantation to predict favourable clinical course (CRT response and/or risk of MACE) in HF patients receiving CRT...
January 16, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28095814/risk-factors-for-aspiration-pneumonia-after-definitive-chemoradiotherapy-or-bio-radiotherapy-for-locally-advanced-head-and-neck-cancer-a-monocentric-case-control-study
#16
Sadayuki Kawai, Tomoya Yokota, Yusuke Onozawa, Satoshi Hamauchi, Akira Fukutomi, Hirofumi Ogawa, Tsuyoshi Onoe, Tetsuro Onitsuka, Takashi Yurikusa, Akiko Todaka, Takahiro Tsushima, Yukio Yoshida, Yosuke Kito, Keita Mori, Hirofumi Yasui
BACKGROUND: Chemoradiotherapy (CRT) and bio-radiotherapy (BRT) are recognized as standard therapies for head and neck cancer (HNC). Aspiration pneumonia after CRT or BRT is a common late adverse event. Our aim in this study was to evaluate the cause-specific incidence of aspiration pneumonia after CRT or BRT and to identify its clinical risk factors. METHODS: We performed a retrospective analysis of 305 patients with locally advanced HNC treated by CRT or BRT between August 2006 and April 2015...
January 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28094171/the-relationship-of-cognitive-improvement-after-cognitive-remediation-with-social-functioning-in-patients-with-schizophrenia-and-severe-cognitive-deficits
#17
J P Lindenmayer, Samantha Fregenti, Guoxin Kang, Veronica Ozog, Isidora Ljuri, Anzalee Khan, A Goldring, Susan R McGurk
BACKGROUND: This study aims to examine the effects of change in neurocognition on functional outcomes and to examine predictors of change in social functions following a 12-week course of cognitive remediation in patients with schizophrenia and schizoaffective disorder with severe cognitive impairments. METHOD: Level of social functioning was assessed using a performance based measure of functional capacity (PSP) in patients prior to and after the completion of 12-week cognitive remediation treatment (CRT)...
January 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28093791/local-therapy-improves-overall-survival-in-patients-with-newly-diagnosed-metastatic-prostate-cancer
#18
Rahul R Parikh, John Byun, Sharad Goyal, Isaac Yi Kim
BACKGROUND: The role of local therapy, in the form of radiation therapy (RT) or radical prostatectomy(RP), and its association on outcomes is not well established in patients with metastatic prostate cancer. METHODS: Using the National Cancer Database (NCDB), we evaluated patterns of care and outcomes among patients diagnosed with metastatic prostate cancer from 2004 to 2013 treated with local therapy (RP, intensity-modulated radiation therapy [IMRT], or 2D/3D-conformal radiation therapy [CRT])...
January 17, 2017: Prostate
https://www.readbyqxmd.com/read/28092940/a-special-issue-of-crt-celebrating-volume-30
#19
Stephen S Hecht
No abstract text is available yet for this article.
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28092004/bio-based-degradation-of-emerging-endocrine-disrupting-and-dye-based-pollutants-using-cross-linked-enzyme-aggregates
#20
Muhammad Bilal, Muhammad Asgher, Hafiz M N Iqbal, Hongbo Hu, Xuehong Zhang
In this study, manganese peroxidase (MnP) from an indigenous white-rot fungus Ganoderma lucidum IBL-05 was insolubilized in the form of cross-linked enzyme aggregates (CLEAs) using various aggregating agents, i.e., acetone, ammonium sulfate, ethanol, 2-propanol, and tert-butanol, followed by glutaraldehyde (GA) cross-linking. The precipitant type, MnP, and GA concentrations affected the CLEAs activity recovery and aggregation yield. Among precipitants used, acetone appeared to be the most efficient aggregation agent, providing the highest activity recovery and aggregation yield of 31...
January 14, 2017: Environmental Science and Pollution Research International
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