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Han-Yu Deng, Gang Li, Jun Luo, Guha Alai
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was: Can definitive chemoradiotherapy (CRT) be an alternative to surgery for early-stage oesophageal cancer? A total of 622 papers were found using the reported search, of which 5 cohort studies represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
July 10, 2018: Interactive Cardiovascular and Thoracic Surgery
Xiaopeng Bai, Guanghui Wang, Yue Sun, Yan Yu, Jude Liu, Decheng Wang, Zhiqin Wang
The mechanism of rod-milling combined with torrefaction as well as its effects on physicochemical and fuel properties of wheat straw were investigated. Rod-milling and hammer-milling samples were torrefied under three temperatures (250, 275, and 300 °C) with a duration time of 30 min. The results indicated that combined rod-milling and torrefaction pretreatment (CRT) significantly elevated carbon content, higher heating value, fuel ratio, and reduced oxygen content and atomic H/C and O/C ratios in wheat straw...
July 7, 2018: Bioresource Technology
W Jeffrey Petty, James J Urbanic, Tamjeed Ahmed, Ryan Hughes, Beverly Levine, Kyle Rusthoven, Michael Papagikos, Jimmy R Ruiz, Brian E Lally, Michael Chan, Hollins Clark, Ralph B D'Agostino, A William Blackstock
PURPOSE: Recent data indicate consolidative radiation therapy (CRT) improves progression free survival (PFS) for patients with oligometastatic non-small cell lung cancer (NSCLC). Data regarding long term outcomes are limited. METHODS AND MATERIALS: In 2010, this prospective, multi-center, single arm, phase II trial was initiated and enrolled patients with oligometastatic NSCLC. Oligometastatic disease was defined as a maximum number of five metastatic lesions for all disease sites including no more than three active extracranial metastatic lesions...
July 9, 2018: International Journal of Radiation Oncology, Biology, Physics
Romain Jouffroy, Anastasia Saade, Jean Pierre Tourtier, Papa Gueye, Emmanuel Bloch-Laine, Patrick Ecollan, Pierre Carli, Benoît Vivien
OBJECTIVES: The early identification of septic shock patients at high risk of poor outcome is essential to early initiate optimal treatments and to decide on hospital admission. Biomarkers are often used to evaluate the severity. In prehospital settings, the availability of biomarkers, such as lactate, is restricted. In this context, clinical tools such as skin mottling score (SMS) and capillary refill time (CRT) are more suitable. In this study, we describe prehospital SMS and CRT's ability to predict mortality of patients with septic shock initially cared in the prehospital setting by a mobile intensive care unit...
July 6, 2018: American Journal of Emergency Medicine
Jeremy Chuang, Jun Gong, Samuel J Klempner, Yanghee Woo, Joseph Chao
The multidisciplinary management of locoregional esophagogastric cancers (GCs) has evolved significantly over the past two decades. While perioperative chemotherapy, adjuvant chemotherapy, and postoperative chemotherapy with chemoradiation (CRT) have demonstrated improved survival when compared to surgery alone, there is no universal standard for resectable gastroesophageal cancer. Current global management patterns vary by geographic region, partly related to phase III data originating from each global region...
June 2018: Journal of Gastrointestinal Oncology
Vivek Verma, Adams Kusi Appiah, Tim Lautenschlaeger, Sebastian Adeberg, Charles B Simone, Chi Lin
Background: Current guidelines recommend chemotherapy (CT) with or without radiotherapy (RT) for unresected intrahepatic cholangiocarcinoma (IC). Although there is currently lack of consensus, previous smaller studies have illustrated the efficacy of local therapy for this population. This investigation evaluated outcomes of chemoradiotherapy (CRT) versus CT alone in unresected IC using a large, contemporary national database. Methods: The National Cancer Data Base (NCDB) was queried for primary IC cases (2004-2013) receiving CT alone or CRT...
June 2018: Journal of Gastrointestinal Oncology
Hassan Kamalzadeh, Shahrooz Yazdani, Mohammad Jalali
In patients with cardiac resynchronization therapy (CRT), loss of left ventricular (LV) stimulation occurs chiefly because of LV lead dislodgement. The occurrence rate of LV lead dislodgement in different reports is between 2% and 12% of patients. LV lead dislodgement precludes clinical improvement. We describe 2 patients with heart failure, fulfilling the criteria for CRT implantation. In both patients, right ventricular and right atrial leads were implanted via the left subclavian vein in the right ventricular apex and the right atrial appendage, respectively...
January 2018: Journal of Tehran Heart Center
Helder Pereira, Tom A Jackson, Benjamin Sieniewicz, Justin Gould, Cheng Yao, Steven Niederer, Christopher A Rinaldi
BACKGROUND: Cardiac resynchronization therapy (CRT) is now generally delivered via quadripolar leads. Assessment of the effect of different vector programs from quadripolar leads on ventricular activation can be now done using non-invasive electrocardiographic mapping (ECM). MATERIAL AND METHODS: In nineteen patients with quadripolar LV leads, activation maps were constructed. The total ventricular activation time (TVaT) and the time for the bulk of ventricular activation (VaT10-90 ) were calculated...
July 2018: Journal of Electrocardiology
Roksana Kisiel, Kamil Fijorek, Paweł Moskal, Piotr Kukla, Tomasz Sondej, Danuta Czarnecka, Marek Jastrzębski
We investigated prognostic value of four recently proposed ECG markers in patients with cardiac resynchronization therapy (CRT): 1./ pathological preimplantation QRS axis, 2./ increase in QRS amplitude in V3 during biventricular pacing, 3./ negative QRS in V1/V2 during left ventricular (LV)-only pacing, 4./ longer QRS duration during LV-only pacing. A longitudinal cohort study was performed (n = 552). RESULTS: During the 9-year observation period the primary endpoint (death from any cause or urgent heart transplantation) was met in 232 patients...
July 2018: Journal of Electrocardiology
Yeon Joo Kim, Su Ssan Kim, Si Yeol Song, Eun Kyung Choi
BACKGROUND: Combined stereotactic body radiotherapy (SBRT) for lung lesions and conventional radiotherapy (CRT) for nodal areas may be more effective than CRT alone in patients with locally advanced lung cancer. METHODS: This study included 21 patients with small primary lung tumors distant from the regional nodal areas. The SBRT dose was 40-60 Gy in 4 fractions. CRT doses were 66 Gy in 30 fractions for non-small cell lung cancer and 52.5 Gy in 25 fractions for small cell lung cancer...
July 11, 2018: Radiation Oncology
Giacomo Borghi, Valerio Tabacchini, René Bakker, Dennis R Schaart
Recently, a monolithic scintillator detector for time-of-flight (TOF) / depth-of-interaction (DOI) positron emission tomography (PET) was developed. It has a detector spatial resolution of ~1.7 mm full-width-at-half-maximum (FWHM), a coincidence resolving time (CRT) of ~215 ps FWHM, and ~4.7 mm FWHM DOI resolution. Here, we demonstrate, for the first time, the imaging performance of this detector in a 70 cm diameter PET geometry. We built a tomographic setup representative of a whole-body clinical scanner, comprising two coaxially rotating arms, each carrying a detector module, and a central, rotating phantom table...
July 11, 2018: Physics in Medicine and Biology
Sophie Giffard-Roisin, Herve Delingette, Thomas Jackson, Jessica Webb, Lauren Fovargue, Jack Lee, C Aldo Rinaldi, Reza Razavi, Nicholas Ayache, Maxime Sermesant
GOAL: Non-invasive cardiac electrophysiology (EP) model personalisation has raised interest for instance in the scope of predicting EP cardiac resynchronization therapy (CRT) response. However, the restricted clinical applicability of current methods is due in particular to the limitation to simple situations and the important computational cost. METHODS: We propose in this manuscript an approach to tackle these two issues. First, we analyse more complex propagation patterns (multiple onsets and scar tissue) using relevance vector regression and shape dimensionality reduction on a large simulated database...
May 23, 2018: IEEE Transactions on Bio-medical Engineering
Rita Ilhão Moreira, Ana Abreu, Guilherme Portugal, Luís Oliveira, Mário Oliveira, Inês Rodrigues, Madalena Coutinho Cruz, Pedro Silva Cunha, Vanessa Santos, Helena Santa Clara, Miguel Mota Carmo, Rui Cruz Ferreira
BACKGROUND: Cardiac autonomic dysfunction as assessed by 123 I-metaiodobenzylguanidine (123 I-mIBG) scintigraphy is associated with poor prognosis in heart failure (HF) patients. Although cardiac resynchronization therapy (CRT) has emerged as an effective therapy in improving outcomes on HF patients, its effect on cardiac sympathetic nervous function is still not fully understood. We aimed to study the value of pre-implantation 123 I-mIBG late heart-to-mediastinum ratio (HMR) as a predictor of response and outcomes after CRT and to correlate modification in this parameter with CRT response and functional improvement...
July 10, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Izumi Tachibana, Yasumasa Nishimura, Masahiro Inada, Kohei Fukuda, Kazuki Ishikawa, Tatsuyuki Nishikawa, Masaki Yokokawa, Kiyoshi Nakamatsu, Shuichi Kanamori, Jin-Ichi Hida
BACKGROUND: Chemoradiotherapy (CRT) is a standard treatment for anal canal cancer although many patients with anal canal cancer undergo surgery in Japan. The efficacy of CRT for anal canal cancer was evaluated retrospectively. METHODS: Medical charts of 13 patients with anal canal cancer treated by definitive CRT from October 2004 to May 2016 were reviewed. Twelve patients had squamous cell carcinoma and one had adeno-squamous carcinoma. PET/CT simulation was performed in nine patients...
July 10, 2018: International Journal of Clinical Oncology
Oliver I Brown, Theodora Nikolaidou, Gowan Beddoes, Angela Hoye, Andrew L Clark
GOAL: The HF-CGM is a proof-of-principle study to investigate whether cardiogoniometry (CGM), a three-dimensional electrocardiographic method, can differentiate between pacing modes in patients with cardiac resynchronisation therapy (CRT). METHODS: At a tertiary cardiology centre, CGM recordings were performed using four pacing modes: no pacing; right ventricular (RV) pacing; left ventricular (LV) pacing and biventricular (BIV) pacing. Three orthogonal CGM planes orientated to the long axis (XY), the frontal plane (YZ) and the short axis (XZ) of the heart were constructed, and the direction of the QRS axis was calculated for each pacing mode in each plane...
November 2, 2017: IEEE Transactions on Bio-medical Engineering
Anthony T C Chan, Edwin P Hui, Roger K C Ngan, Stewart Y Tung, Ashley C K Cheng, Wai T Ng, Victor H F Lee, Brigette B Y Ma, Hoi C Cheng, Frank C S Wong, Herbert H F Loong, Macy Tong, Darren M C Poon, Anil T Ahuja, Ann D King, Ki Wang, Frankie Mo, Benny C Y Zee, K C Allen Chan, Y M Dennis Lo
Purpose The contribution of adjuvant chemotherapy after chemoradiation therapy (CRT) in nasopharyngeal cancer (NPC) remains controversial. Plasma Epstein-Barr virus (EBV) DNA is a potential biomarker of subclinical residual disease in NPC. In this prospective, multicenter, randomized controlled trial, we used plasma EBV DNA to identify patients with NPC at a higher risk of relapse for adjuvant chemotherapy. Patients and Methods Eligible patients with histologically confirmed NPC of Union for International Cancer Control stage IIB to IVB, adequate organ function, and no locoregional disease or distant metastasis were screened by plasma EBV DNA at 6 to 8 weeks after radiotherapy (RT)...
July 10, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Cory Pettit, Amy Webb, Steve Walston, Moumita Chatterjee, Wei Chen, Wendy Frankel, Carlo Croce, Terence M Williams
Purpose: There has been growing interest in using chemoradiation (CRT) for non-operative management of rectal cancer, and identifying patients who might benefit most from this approach is crucial. This study identified miRNAs (miRs) associated with clinical outcomes and treatment resistance by evaluating both pre- and post-CRT expression profiles. Methods: Forty patients, 9 with pathologic complete response (pCR) and 31 with pathologic incomplete response (pIR) were included...
June 22, 2018: Oncotarget
Felix Rommel, Fynn Siegfried, Maximilian Kurz, Max Philipp Brinkmann, Matthias Rothe, Martin Rudolf, Salvatore Grisanti, Mahdy Ranjbar
Purpose: To evaluate the impact of correct anatomical slab segmentation on foveal avascular zone (FAZ) dimensions in the superficial capillary plexus (SCP) and deep capillary plexus (DCP) using optical coherence tomography angiography (OCTA). Methods: Participants with healthy retinas were recruited, and 5 × 5 mm OCTA images were acquired using the Canon HS-100 Angio eXpert module. FAZ size was measured in automatically (AS, manufacturer-based) and manually (MS, anatomical-based) segmented OCTA slabs by two experienced graders...
June 2018: Journal of Current Ophthalmology
Michele Valmasoni, Elisa Sefora Pierobon, Gianpietro Zanchettin, Dario Briscolini, Lucia Moletta, Alberto Ruol, Renato Salvador, Stefano Merigliano
BACKGROUND: Few studies have examined optimal treatment specifically for cervical esophageal carcinoma. This study evaluated the outcome of three common treatment strategies with a focus on the debated role of surgery. METHODS: All patients with cervical esophageal cancer treated at a single center were identified and their outcomes analyzed in terms of morbidity, mortality, and recurrence according to the treatment they received, i.e. surgery alone, definitive platinum-based chemoradiation (CRT), or CRT followed by surgery...
July 9, 2018: Annals of Surgical Oncology
Andrea P Falanga, Pietro Melone, Roberta Cagliani, Nicola Borbone, Stefano D'Errico, Gennaro Piccialli, Paolo A Netti, Daniela Guarnieri
The development of new strategies for enhancing drug delivery to the brain represents a major challenge in treating cerebral diseases. In this paper, we report on the synthesis and structural characterization of a biocompatible nanoparticle (NP) made up of poly(lactic-co-glycolic acid) (PLGA)-polyethylene glycol (PEG) co-polymer (namely PELGA) functionalized with the membranotropic peptide gH625 (gH) and the iron-mimicking peptide CRTIGPSVC (CRT) for transport across the blood-brain barrier (BBB). gH possesses a high translocation potency of the cell membrane...
July 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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