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https://www.readbyqxmd.com/read/29780848/controlled-human-hookworm-infection-accelerating-human-hookworm-vaccine-development
#1
David Diemert, Doreen Campbell, Jill Brelsford, Caitlyn Leasure, Guangzhao Li, Jin Peng, Maria Zumer, Naji Younes, Maria Elena Bottazzi, Rojelio Mejia, David I Pritchard, John M Hawdon, Jeffrey M Bethony
Background: Controlled human hookworm infection (CHHI) is a central component of a proposed hookworm vaccination-challenge model (HVCM) to test the efficacy of candidate vaccines. Critical to CHHI is the manufacture of Necator americanus infective larvae ( Na L3) according to current Good Manufacturing Practice (cGMP) and the determination of an inoculum of Na L3 that is safe and reliably induces patent infection. Methods: cGMP-grade Na L3 were produced for a phase 1 trial in 20 healthy, hookworm-naïve adults in the United States, who received either 25 or 50 Na L3...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29775454/in-vivo-and-in-vitro-studies-of-cry5b-and-nicotinic-acetylcholine-receptor-agonist-anthelmintics-reveal-a-powerful-and-unique-combination-therapy-against-intestinal-nematode-parasites
#2
Yan Hu, Melanie Miller, Bo Zhang, Thanh-Thanh Nguyen, Martin K Nielsen, Raffi V Aroian
BACKGROUND: The soil-transmitted nematodes (STNs) or helminths (hookworms, whipworms, large roundworms) infect the intestines of ~1.5 billion of the poorest peoples and are leading causes of morbidity worldwide. Only one class of anthelmintic or anti-nematode drugs, the benzimidazoles, is currently used in mass drug administrations, which is a dangerous situation. New anti-nematode drugs are urgently needed. Bacillus thuringiensis crystal protein Cry5B is a powerful, promising new candidate...
May 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29774300/epidemiology-of-intestinal-parasite-infections-in-three-departments-of-south-central-c%C3%A3-te-d-ivoire-before-the-implementation-of-a-cluster-randomised-trial
#3
Gaoussou Coulibaly, Mamadou Ouattara, Kouassi Dongo, Eveline Hürlimann, Fidèle K Bassa, Naférima Koné, Clémence Essé, Richard B Yapi, Bassirou Bonfoh, Jürg Utzinger, Giovanna Raso, Eliézer K N'Goran
Hundreds of millions of people are infected with helminths and intestinal protozoa, particularly children in low- and middle-income countries. Preventive chemotherapy is the main strategy to control helminthiases. However, rapid re-infection occurs in settings where there is a lack of clean water, sanitation and hygiene. In August and September 2014, we conducted a cross-sectional epidemiological survey in 56 communities of three departments of south-central Côte d'Ivoire. Study participants were invited to provide stool and urine samples...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29772478/bacillus-thuringiensis-cry5b-protein-as-a-new-pan-hookworm-cure
#4
Yan Hu, Thanh-Thanh Nguyen, Alice C Y Lee, Joseph F Urban, Melanie M Miller, Bin Zhan, David J Koch, Jason B Noon, Ambily Abraham, Ricardo Toshio Fujiwara, Dwight D Bowman, Gary R Ostroff, Raffi V Aroian
Hookworms are intestinal nematode parasites that infect nearly half a billion people and are globally one of the most important contributors to iron-deficiency anemia. These parasites have significant impacts in developing children, pregnant women and working adults. Of all the soil-transmitted helminths or nematodes (STNs), hookworms are by far the most important, with disease burdens conservatively estimated at four million DALYs (Disability-Adjusted Life Years) and with productivity losses of up to US$139 billion annually...
May 4, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29770668/-surveillance-of-soil-borne-nematodiasis-in-population-in-hefei-city-2012-2015
#5
Pan Xiao-Xiang, An Jin-Sheng, Zhu Li, Wei Hong-Sheng
OBJECTIVE: To analyze the surveillance results of soil-borne nematodiasis in Hefei City from 2012 to 2015, so as to provide the evidence formulating the Hefei "Thirteen-five" parasitic disease prevention strategy. METHODS: The population in monitoring points in Changfeng County, Lujiang City and Chaohu County were investigated for Ascaris lumbricoides , Trichuristrichiura and hookworm infections with Kato-Katz technique every year from 2012 to 2015, and the children aged less than 6 years were checked for Enterobius vermicularis infection by using the cellophane tape method...
February 10, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29770664/-survey-and-analysis-of-major-human-parasitic-diseases-in-chongqing-city
#6
Li Shan-Shan, Luo Fei, Xie Jun, Yuan Yi
OBJECTIVE: To investigate the epidemic of major human parasitic diseases in Chongqing City, so as to provide a reference for developing prevention and control strategies. METHODS: According to the unified methods formulated by the national investigation scheme and stratified cluster random sampling, 36 rural pilots and 50 urban pilots were selected in Chongqing City. The number of the objects investigated in individual pilot was defined over 250. RESULTS: Totally 22 263 residents were detected...
March 2, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29760697/hookworm-secreted-extracellular-vesicles-interact-with-host-cells-and-prevent-inducible-colitis-in-mice
#7
Ramon M Eichenberger, Stephanie Ryan, Linda Jones, Geraldine Buitrago, Ramona Polster, Marcela Montes de Oca, Jennifer Zuvelek, Paul R Giacomin, Lindsay A Dent, Christian R Engwerda, Matthew A Field, Javier Sotillo, Alex Loukas
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such potent suppressors of inflammation that they have been used in clinical trials to treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description of helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from different helminths have been characterized and their salient roles in parasite-host interactions have been highlighted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29746467/disentangling-complex-parasite-interactions-protection-against-cerebral-malaria-by-one-helminth-species-is-jeopardized-by-co-infection-with-another
#8
Jessica L Abbate, Vanessa O Ezenwa, Jean-François Guégan, Marc Choisy, Mathieu Nacher, Benjamin Roche
Multi-species interactions can often have non-intuitive consequences. However, the study of parasite interactions has rarely gone beyond the effects of pairwise combinations of species, and the outcomes of multi-parasite interactions are poorly understood. We investigated the effects of co-infection by four gastrointestinal helminth species on the development of cerebral malaria among Plasmodium falciparum-infected patients. We characterized associations among the helminth parasite infra-community, and then tested for independent (direct) and co-infection dependent (indirect) effects of helminths on cerebral malaria risk...
May 10, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29744977/the-management-of-anaemia-and-haematinic-deficiencies-in-pregnancy-and-post-partum
#9
REVIEW
N B A Roy, S Pavord
Anaemia is one of the most common disorders in the world (24·8% of the world population) (de Benoist 2008) and affects patients of all ages and ethnic origins. Underlying causes and prevalences vary by age group and socioeconomic background, but pregnant women everywhere are at high risk of anaemia, the vast majority of cases being due to iron deficiency. One in four pregnant women in Europe are thought to have iron deficiency anaemia (Daru et al., March 2016), whereas in parts of Africa, where hookworm infestation is common, this has been estimated to be as high as 38% (Stevens et al...
April 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29726969/prevalence-of-strongyloides-stercoralis-infection-and-other-soil-transmitted-helminths-by-cross-sectional-survey-in-a-rural-community-in-gisagara-district-southern-province-rwanda
#10
Aloys Tuyizere, Alphonse Ndayambaje, Timothy D Walker, Claude Bayingana, Cyprien Ntirenganya, Vincent Dusabejambo, DeVon C Hale
Background: Strongyloides stercoralis is one of the most neglected tropical diseases. Sparse, dated central African and Rwandan data on seroprevalence are available to guide public health efforts and clinical care. Methods: In February 2016 we conducted a community-based cross-sectional study among 539 asymptomatic participants in a rural area in the Gisagara District, Southern Province, Rwanda. Direct faecal smear (DFS) and modified Koga agar plate culture (APC) were used to detect S...
May 2, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29705768/soil-transmitted-helminth-infections-and-nutritional-status-in-ecuador-findings-from-a-national-survey-and-implications-for-control-strategies
#11
Ana L Moncayo, Raquel Lovato, Philip J Cooper
OBJECTIVE: The estimation of prevalence and intensity of soil-transmitted helminth (STH) infections at a country-level is an essential prerequisite for the implementation of a rational control programme. The aim of this present study was to estimate the prevalence and distribution of STH infections and malnutrition in school-age children in rural areas of Ecuador. DESIGN: Cross-sectional study from October 2011 to May 2012. SETTING: Eighteen rural schools were randomly selected from the three ecological regions of Ecuador (coastal, highlands and Amazon basin)...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29702653/efficacy-and-safety-of-co-administered-ivermectin-plus-albendazole-for-treating-soil-transmitted-helminths-a-systematic-review-meta-analysis-and-individual-patient-data-analysis
#12
Marta S Palmeirim, Eveline Hürlimann, Stefanie Knopp, Benjamin Speich, Vicente Belizario, Serene A Joseph, Michel Vaillant, Piero Olliaro, Jennifer Keiser
BACKGROUND: The soil-transmitted helminths (STH), Ascaris lumbricoides, Trichuris trichiura and hookworms infect 1.5 billion people worldwide and cause an estimated burden of 3.3 million disability-adjusted life years (DALYs). Current control strategies focus on morbidity reduction through preventive chemotherapy (PC) but the most commonly used recommended drugs (albendazole and mebendazole) are particularly inefficacious against T. trichiura. This, together with the threat of emerging drug resistance, calls for new control strategies, including co-administration with other anthelminthics...
April 27, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29699040/-epidemiology-related-to-soil-borne-nematode-disease-in-danzhou-city-hainan-province
#13
B Hu, G Z Chen, P Huang
Objective: To understand the prevalence, trend and related factors on soil-borne nematode in Danzhou city to provide information for prevention and control of the disease. Methods: According to the guidelines set by the National National soil-borne nematode technical solutions, one village was randomly chosen from every township as the monitoring location, in the east, west, south and north parts of Danzhou city. A total of 200 residents aged 3 years and over were randomly selected in each monitoring site, with modified Kato thick smear and Cellophane tape anal swab used for microscopy...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29695368/hookworm-in-the-eye
#14
Zui Tao, Ying Wang, Shasha Yu, Zheng Qin Yin, Yong Liu, Shiying Li
No abstract text is available yet for this article.
May 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29673735/efficacy-and-tolerability-of-triple-drug-therapy-with-albendazole-pyrantel-pamoate-and-oxantel-pamoate-compared-with-albendazole-plus-oxantel-pamoate-pyrantel-pamoate-plus-oxantel-pamoate-and-mebendazole-plus-pyrantel-pamoate-and-oxantel-pamoate-against-hookworm
#15
Wendelin Moser, Somphou Sayasone, Syda Xayavong, Bangon Bounheuang, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser
BACKGROUND: Albendazole and mebendazole are commonly used to control hookworm, but have shortcomings in their efficacy profiles. We assessed whether triple drug therapy (TDT) with albendazole, pyrantel pamoate, and oxantel pamoate was more effective than the co-administration of two drugs for the treatment of hookworm infections. METHODS: A randomised, single-blind trial was done from Sept 27 until Nov 17, 2017, in Laos. Children (6-15 years) from six schools were invited to participate...
April 16, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29666698/prevalence-of-intestinal-parasites-and-associated-factors-among-pulmonary-tuberculosis-suspected-patients-attending-university-of-gondar-hospital-gondar-northwest-ethiopia
#16
Yalewayker Tegegne, Tadelo Wondmagegn, Ligabaw Worku, Ayalew Jejaw Zeleke
Introduction: Intestinal parasitic infections are among the major public health problems in developing countries. Hence, it is significant to explore coinfection with intestinal parasites and pulmonary tuberculosis because coinfection increases the complexity of control and prevention of pulmonary tuberculosis and parasitic diseases. Objective: To assess the prevalence of intestinal parasites among pulmonary tuberculosis suspected patients. Method: Institutional based cross-sectional study was conducted at University of Gondar Hospital from March to May, 2017...
2018: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29622908/soil-contamination-rate-prevalence-intensity-of-infection-of-geohelminths-and-associated-risk-factors-among-residents-in-bazou-west-cameroon
#17
Blandine Ngatou Tchakounté, Vanessa Rosine Nkouayep, Josué Wabo Poné
Background: Soil-transmitted helminths (STH) infections remain an important public health problem in the tropics. This study aimed to evaluate the soil contamination rate and prevalence of infestations of geohelminth among residents in Bazou. Methods: Four hundred (400) soil samples and 182 stool specimens were collected respectively from four sites and from inhabitants aged 1 to 40 years and above in 12 households. A questionnaire was administered to evaluate risk factors of STH-infections...
January 2018: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29611504/albendazole-treatment-improves-work-capacity-in-women-smallholder-farmers-infected-with-hookworm-a-double-blind-randomized-control-trial
#18
Margaret Salmon, Christian Salmon, Maurice Masoda, Jean-Maurice Salumu, Carmine Bozzi, Phil Nieburg, Lisa M Harrison, Debbie Humphries, Naomi Abaca Uvon, Sarah K Wendel, Clint Trout, Michael Cappello
An estimated 4.7 billion people live in regions exposed to soil-transmitted helminths, intestinal parasites that have significant impacts on the health of women smallholder farmers. The goal of this trial was to determine whether treatment with albendazole impacts the work capacity of these farmers. This is a prospective double-blind, randomized effectiveness trial. Participants ( N = 250) were randomly selected from safe motherhood groups in the Democratic Republic of Congo. Prevalence/intensity of hookworm infection, hemoglobin, and demographics was obtained...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29611502/empowering-girls-and-women-through-hookworm-prevention
#19
Peter J Hotez
No abstract text is available yet for this article.
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29609247/-stratified-sampling-survey-of-major-human-parasitic-diseases-in-henan-province
#20
B L Xu, H W Zhang, Y Deng, Z L Chen, W Q Chen, D L Lu, Y L Zhang, Y L Zhao, X M Lin, Q Huang, C Y Yang, Y Liu, R M Zhou, P Li, J S Chen, L J He, D Qian
Objective: To understand the prevalence of major human parasitic diseases and related factors in Henan province. Methods: This stratified sampling survey was carried out according to the requirement of national survey protocol of major human parasitic diseases, 2014-2015. The prevalence of soil-transmitted helminths infection, taeniasis and intestinal protozoiasis were surveyed in 104 sites selected from 35 counties (districts) and the prevalence of clonorchiasis was surveyed in 62 sites selected from 37 townships...
March 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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