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https://www.readbyqxmd.com/read/29346440/geographical-distribution-of-soil-transmitted-helminths-and-the-effects-of-community-type-in-south-asia-and-south-east-asia-a-systematic-review
#1
Zachary A Silver, Saravanakumar P Kaliappan, Prasanna Samuel, Srinivasan Venugopal, Gagandeep Kang, Rajiv Sarkar, Sitara S R Ajjampur
BACKGROUND: Soil-transmitted helminth (STH) infections are among the most prevalent neglected tropical diseases (NTD) worldwide. Since the publication of the WHO road map to combat NTD in 2012, there has been a renewed commitment to control STH. In this study, we analysed the geographical distribution and effect of community type on prevalence of hookworm, Trichuris and Ascaris in south Asia and south east Asia. METHODOLOGY: We conducted a systematic review of open-access literature published in PubMed Central and the Global Atlas of Helminth Infection...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346412/a-comparative-analysis-of-preservation-techniques-for-the-optimal-molecular-detection-of-hookworm-dna-in-a-human-fecal-specimen
#2
Marina Papaiakovou, Nils Pilotte, Ben Baumer, Jessica Grant, Kristjana Asbjornsdottir, Fabian Schaer, Yan Hu, Raffi Aroian, Judd Walson, Steven A Williams
BACKGROUND: Proper collection and storage of fecal samples is necessary to guarantee the subsequent reliability of DNA-based soil-transmitted helminth diagnostic procedures. Previous research has examined various methods to preserve fecal samples for subsequent microscopic analysis or for subsequent determination of overall DNA yields obtained following DNA extraction. However, only limited research has focused on the preservation of soil-transmitted helminth DNA in stool samples stored at ambient temperature or maintained in a cold chain for extended periods of time...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346366/testing-for-soil-transmitted-helminth-transmission-elimination-analysing-the-impact-of-the-sensitivity-of-different-diagnostic-tools
#3
Marleen Werkman, James E Wright, James E Truscott, Alice V Easton, Rita G Oliveira, Jaspreet Toor, Alison Ower, Kristjana H Ásbjörnsdóttir, Arianna R Means, Sam H Farrell, Judd L Walson, Roy M Anderson
In recent years, an increased focus has been placed upon the possibility of the elimination of soil-transmitted helminth (STH) transmission using various interventions including mass drug administration. The primary diagnostic tool recommended by the WHO is the detection of STH eggs in stool using the Kato-Katz (KK) method. However, detecting infected individuals using this method becomes increasingly difficult as the intensity of infection decreases. Newer techniques, such as qPCR, have been shown to have greater sensitivity than KK, especially at low prevalence...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29343694/sertraline-paroxetine-and-chlorpromazine-are-rapidly-acting-anthelmintic-drugs-capable-of-clinical-repurposing
#4
Janis C Weeks, William M Roberts, Caitlyn Leasure, Brian M Suzuki, Kristin J Robinson, Heather Currey, Phurpa Wangchuk, Ramon M Eichenberger, Aleen D Saxton, Thomas D Bird, Brian C Kraemer, Alex Loukas, John M Hawdon, Conor R Caffrey, Nicole F Liachko
Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for anthelmintic activity against the soil nematode Caenorhabditis elegans. From this screen, we found that the neuromodulatory drugs sertraline, paroxetine, and chlorpromazine kill C. elegans at multiple life stages including embryos, developing larvae and gravid adults...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329561/strongyloides-stercoralis-and-hookworm-co-infection-spatial-distribution-and-determinants-in-preah-vihear-province-cambodia
#5
Armelle Forrer, Virak Khieu, Fabian Schär, Penelope Vounatsou, Frédérique Chammartin, Hanspeter Marti, Sinuon Muth, Peter Odermatt
BACKGROUND: Strongyloides stercoralis and hookworm are two soil-transmitted helminths (STH) that are highly prevalent in Cambodia. Strongyloides stercoralis causes long-lasting infections and significant morbidity but is largely neglected, while hookworm causes the highest public health burden among STH. The two parasites have the same infection route, i.e. skin penetration. The extent of co-distribution, which could result in potential high co-morbidities, is unknown in highly endemic settings like Cambodia...
January 12, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29302643/burden-and-determinant-factors-of-anemia-among-elementary-school-children-in-northwest-ethiopia-a-comparative-cross-sectional-study
#6
Berhanu Elfu Feleke, Awoke Derbie, Yohannes Zenebe, Daniel Mekonnen, Tadesse Hailu, Begna Tulu, Yesuf Adem, Fetlework Bereded, Fantahun Biadglegne
Background: Anemia is an indicator of both poor nutrition and health. In low-income countries like Ethiopia, the prevalence of anemia remains high due to several determinant factors. There is a lack of regular surveillance system to determine the magnitude of anemia among school age children. The aim of this study was to determine the burden and determinant factors of anemia among school children. Materials and Methods: A comparative cross-sectional study was conducted from March 2014 to May 2014 among elementary school children in Northwest Ethiopia...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29261231/the-study-of-host-immune-responses-elicited-by-the-model-murine-hookworms-nippostrongylus-brasiliensis-and-heligmosomoides-polygyrus
#7
T Bouchery, B Volpe, K Shah, L Lebon, K Filbey, G LeGros, N Harris
Hookworm infections (Necator americanus or Ancylostoma duodenale) represent a major neglected tropical disease, affecting approximately 700 million people worldwide, and can cause severe morbidity due to the need for these worms to feed on host blood. N. brasiliensis and H. polygrus, both rodent parasites, are the two most commonly employed laboratory models of experimental hookworm infection. Both parasites evoke type 2 immune responses, and their use has been instrumental in generating fundamental insight into the molecular mechanisms of type-2 immunity and for understanding how the immune response can control parasite numbers...
December 20, 2017: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/29250439/the-effect-of-deworming-using-triple-dose-albendazole-on-nutritional-status-of-children-in-perobatang-village-southwest-sumba-indonesia
#8
Saleha Sungkar, Asri S Ridwan, Gladys Kusumowidagdo
High prevalence of STH leads to malnutrition, anemia, cognitive impairment, and growth disorders. Triple-dose albendazole 400 mg is a broad-spectrum anthelminthic; however, its effectiveness varies in every region. This study aims to determine the benefits of deworming using triple-dose albendazole on children's nutritional status in Perobatang Village, Southwest Sumba, Indonesia. This pre-post study was conducted in July 2016 and January 2017. Children aged 1-15 years were asked to collect stool for diagnosis of STH infection (Kato-Katz method), were measured for anthropometry status to obtain the nutritional status, and took albendazole 400 mg for three consecutive days...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29250122/estimating-the-health-risk-associated-with-the-use-of-ecological-sanitation-toilets-in-malawi
#9
Save Kumwenda, Chisomo Msefula, Wilfred Kadewa, Bagrey Ngwira, Tracy Morse
Use of Ecological Sanitation (EcoSan) sludge is becoming popular due to increasing price of organic fertilizers in Malawi; however, there is little evidence on the associated risks. Quantitative microbiological risk assessment (QMRA) was done to determine health risks associated with use of EcoSan. Pathogens considered included Escherichia coli (E. coli), Salmonella, and soil transmitted helminths (STHs). Exponential and Beta Poisson models were used to estimate the risk from helminthic and bacterial pathogens, respectively...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/29246169/ancylostoma-ceylanicum-infective-third-stage-larvae-are-activated-by-co-culture-with-ht-29-mtx-intestinal-epithelial-cells
#10
Caitlin M Feather, John M Hawdon, John C March
BACKGROUND: Human hookworm larvae arrest development until they enter an appropriate host. This makes it difficult to access the larvae for studying larval development or host-parasite interactions. While there are in vivo and in vitro animal models of human hookworm infection, there is currently no human, in vitro model. While animal models have provided much insight into hookworm biology, there are limitations to how closely this can replicate human infection. Therefore, we have developed a human, in vitro model of the initial phase of hookworm infection using intestinal epithelial cell culture...
December 15, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29243242/cross-sectional-survey-of-health-management-and-prevalence-of-vector-borne-diseases-endoparasites-and-ectoparasites-in-samoan-dogs
#11
R J Carslake, K E Hill, K Sjölander, S F Hii, D Prattley, E Acke
OBJECTIVE: To determine the prevalence of selected canine vector-borne diseases (Leishmania infantum, Anaplasma spp., Ehrlichia canis, Borrelia burgdorferi and Dirofilaria immitis) and endo- and ectoparasites in Samoan dogs presenting for surgical sterilisation and to report on the general health management of the dogs. METHODS: This study was a prospective serological cross-sectional survey. Management data were obtained for 242 dogs by interview with their owners...
December 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29238615/profile-of-geohelminth-eggs-cysts-and-oocysts-of-protozoans-contaminating-the-soils-of-ten-primary-schools-in-dschang-west-cameroon
#12
Vanessa Rosine Nkouayep, Blandine Ngatou Tchakounté, Josué Wabo Poné
Helminthiasis and protozoans infections have been recognized as an important public health problem. The aim of the present study was to screen soil samples collected from 10 primary schools in the city of Dschang for the presence of soil-transmitted helminth eggs, cysts, and oocysts of protozoans. A total of 400 soil samples were collected around latrines, at playgrounds, and behind classrooms in each school. These samples were examined using the sucrose flotation method. From the result obtained, an overall contamination rate of 7...
2017: Journal of Parasitology Research
https://www.readbyqxmd.com/read/29228009/prevalence-of-anemia-and-associated-factors-among-pregnant-women-in-southern-ethiopia-a-community-based-cross-sectional-study
#13
Meaza Lebso, Anchamo Anato, Eskindir Loha
BACKGROUND: Anemia is defined as a condition in which there is less than the normal hemoglobin (Hb) level in the body. During pregnancy; iron deficiency is associated with multiple adverse outcomes for both mother and infant. Most of the studies conducted in Ethiopia on anemia during pregnancy were conducted at institution level and associated factors are not well studied and documented. Independent factors like, food security status, dietary diversity and intestinal parasites infection were considered by only a few of them...
2017: PloS One
https://www.readbyqxmd.com/read/29216182/the-physicochemical-fingerprint-of-necator-americanus
#14
Veeren M Chauhan, David J Scurr, Thomas Christie, Gary Telford, Jonathan W Aylott, David I Pritchard
Necator americanus, a haematophagous hookworm parasite, infects ~10% of the world's population and is considered to be a significant public health risk. Its lifecycle has distinct stages, permitting its successful transit from the skin via the lungs (L3) to the intestinal tract (L4 maturing to adult). It has been hypothesised that the L3 larval sheath, which is shed during percutaneous infection (exsheathment), diverts the immune system to allow successful infection and reinfection in endemic areas. However, the physicochemical properties of the L3 larval cuticle and sheath, which are in direct contact with the skin and its immune defences, are unknown...
December 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29183397/schistosomiasis-intestinal-helminthiasis-and-nutritional-status-among-preschool-aged-children-in-sub-urban-communities-of-abeokuta-southwest-nigeria
#15
Adebiyi Abdulhakeem Adeniran, Hammed Oladeji Mogaji, Adeyinka A Aladesida, Ibiyemi O Olayiwola, Akinola Stephen Oluwole, Eniola Michael Abe, Dorcas B Olabinke, Oladimeji Michael Alabi, Uwem Friday Ekpo
OBJECTIVE: Schistosomiasis and intestinal helminthiasis are major public health problems with school-aged children considered the most at-risk group. Pre-school aged children (PSAC) are excluded from existing control programs because of limited evidence of infections burden among the group. We assessed the prevalence of infections and effect on nutritional status of preschool aged children in Abeokuta, Southwestern Nigeria. RESULTS: A community-based cross-sectional study involving 241 children aged 0-71 months was conducted in 4 sub-urban communities of Abeokuta...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29183355/intestinal-parasitosis-and-anaemia-among-patients-in-a-health-center-north-ethiopia
#16
Megbaru Alemu, Birhane Kinfe, Desalegn Tadesse, Wondemagegn Mulu, Tadesse Hailu, Endalew Yizengaw
OBJECTIVE: The aim of this cross-sectional study was to determine the magnitude of intestinal parasitosis and anaemia in a Health Center, North Ethiopia. RESULTS: A total of 427 outpatients were enrolled and the median age of the participants was 22 years. The prevalence of intestinal parasitosis was 143 (33.5%). Age, place of residence and occupation were significantly associated with intestinal parasitosis. When we see parasite specific factors, significant associations were observed for source of drinking water (P = 0...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29176840/turning-poop-into-profit-cost-effectiveness-and-soil-transmitted-helminth-infection-risk-associated-with-human-excreta-reuse-in-vietnam
#17
Ngan Tran-Thi, Rachel J Lowe, Janna M Schurer, Tu Vu-Van, Lauren E MacDonald, Phuc Pham-Duc
Human excreta is a low cost source of nutrients vital to plant growth, but also a source of pathogens transmissible to people and animals. We investigated the cost-savings and infection risk of soil transmitted helminths (STHs) in four scenarios where farmers used either inorganic fertilizer or fresh/composted human excreta supplemented by inorganic fertilizer to meet the nutrient requirements of rice paddies in the Red River Delta, Vietnam. Our study included two main components: 1) a risk estimate of STH infection for farmers who handle fresh excreta, determined by systematic review and meta-analysis; and 2) a cost estimate of fertilizing rice paddies, determined by nutrient assessment of excreta, a retailer survey of inorganic fertilizer costs, and a literature review to identify region-specific inputs...
November 27, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29169386/spatiotemporal-distribution-and-population-at-risk-of-soil-transmitted-helminth-infections-following-an-eight-year-school-based-deworming-programme-in-burundi-2007-2014
#18
Mohamad Assoum, Giuseppina Ortu, Maria-Gloria Basáñez, Colleen Lau, Archie C A Clements, Kate Halton, Alan Fenwick, Ricardo J Soares Magalhães
BACKGROUND: Investigating the effect of successive annual deworming rounds on the spatiotemporal distribution of infection prevalence and numbers at risk for soil-transmitted helminths (STHs) can help identify communities nearing elimination and those needing further interventions. In this study, we aim to quantify the impact of an 8-year mass drug administration (MDA) programme (from 2007 to 2014) on the spatiotemporal distribution of prevalence of STH infections and to estimate the number of school-aged children infected with STHs in Burundi...
November 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29168467/temporal-trends-of-intestinal-parasites-in-patients-attending-a-tertiary-care-hospital-in-south-india-a-seven-year-retrospective-analysis
#19
Ira Praharaj, Rajiv Sarkar, Sitara Swarna Rao Ajjampur, Sheela Roy, Gagandeep Kang
BACKGROUND & OBJECTIVES: Intestinal parasitic infections and their associated complications are a major cause of morbidity in the developing world. This retrospective study was done to assess the prevalence of intestinal parasitic infections among patients in a tertiary healthcare setting and to analyze age-, gender- and time-related trends in the prevalence of these intestinal parasites over a seven year period (2006-2012). METHODS: The presence of various intestinal parasites in a tertiary care setting over a seven year period in different age groups was determined by performing routine stool microscopy...
July 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29165212/newly-arrived-african-migrants-to-spain-epidemiology-and-burden-disease
#20
Joaquín Salas-Coronas, María Teresa Cabezas-Fernández, Ana Belén Lozano-Serrano, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, José Ángel Cuenca-Gómez
The aim of this study is to describe the epidemiological profile, clinical characteristics, and microbiological findings in African immigrants newly arrived to Spain attended at a specialized reference unit from October 2004 to February 2017. A common protocol for the screening of imported and cosmopolitan diseases was designed to evaluate patients with ≤ 12 months of stay in Spain. A total of 523 patients were included in the study, 488 (93.3%) of sub-Saharan origin. A high number of helminthic infections were diagnosed in sub-Saharan patients, including geohelminthiasis (hookworms 14...
November 20, 2017: American Journal of Tropical Medicine and Hygiene
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