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https://www.readbyqxmd.com/read/27903301/high-prevalence-of-strongyloides-stercoralis-in-school-aged-children-in-a-rural-highland-of-north-western-ethiopia-the-role-of-intensive-diagnostic-work-up
#1
Aranzazu Amor, Esperanza Rodriguez, José M Saugar, Ana Arroyo, Beatriz López-Quintana, Bayeh Abera, Mulat Yimer, Endalew Yizengaw, Derejew Zewdie, Zimman Ayehubizu, Tadesse Hailu, Wondemagegn Mulu, Adriana Echazú, Alejandro J Krolewieki, Pilar Aparicio, Zaida Herrador, Melaku Anegagrie, Agustín Benito
BACKGROUND: Soil-transmitted helminthiases (hookworms, Ascaris lumbricoides and Trichuris trichiura) are extremely prevalent in school-aged children living in poor sanitary conditions. Recent epidemiological data suggest that Strongyloides stercoralis is highly unreported. However, accurate data are essential for conducting interventions aimed at introducing control and elimination programmes. METHODS: We conducted a cross-sectional survey of 396 randomly selected school-aged children in Amhara region in rural area in north-western Ethiopia, to assess the prevalence of S...
December 1, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27895843/severe-anemia-in-malawian-children
#2
Job Cj Calis, Kamija S Phiri, E Brian Faragher, Bernard J Brabin, Imelda Bates, Luis E Cuevas, Rob J de Haan, Ajib I Phiri, Pelani Malange, Mirriam Khoka, Paul Jm Hulshof, Lisette van Lieshout, Marcel Ghm Beld, Yik Y Teo, Kirk A Rockett, Anna Richardson, Dominic P Kwiatkowski, Malcolm E Molyneux, Michaël Boele van Hensbroek
BACKGROUND: Severe anemia is a major cause of sickness and death in African children, yet the causes of anemia in this population have been inadequately studied. METHODS: We conducted a case-control study of 381 preschool children with severe anemia (hemoglobin concentration, <5.0 g per deciliter) and 757 preschool children without severe anemia in urban and rural settings in Malawi. Causal factors previously associated with severe anemia were studied. The data were examined by multivariate analysis and structural equation modeling...
September 2016: Malawi Medical Journal: the Journal of Medical Association of Malawi
https://www.readbyqxmd.com/read/27895280/effectiveness-of-albendazole-for-hookworm-varies-widely-by-community-and-correlates-with-nutritional-factors-a-cross-sectional-study-of-school-age-children-in-ghana
#3
Debbie Humphries, Sara Nguyen, Sunny Kumar, Josephine E Quagraine, Joseph Otchere, Lisa M Harrison, Michael Wilson, Michael Cappello
Mass drug administration (MDA) targeting school-age children is recommended by the World Health Organization for the global control of soil-transmitted helminth (STH) infections. Although considered safe and cost-effective to deliver, benzimidazole anthelminthics are variably effective against the three most common STNs, and widespread use has raised concern about the potential for emerging resistance. To identify factors mediating response to albendazole, we conducted a cross-sectional study of hookworm infection in the Kintampo North Municipality of Ghana in 2011...
November 28, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27888125/initiating-ntd-programs-targeting-schistosomiasis-and-soil-transmitted-helminthiasis-in-two-provinces-of-the-democratic-republic-of-the-congo-establishment-of-baseline-prevalence-for-mass-drug-administration
#4
Achille Kabore, Moudachirou Ibikounle, Jean Jacques Tougoue, Sylvain Mupoyi, Martin Ndombe, Scott Shannon, Eric A Ottesen, Faustin Mukunda, Naomi Awaca
BACKGROUND: Schistosomiasis (SCH) and soil-transmitted helminthiasis (STH) are widely distributed in the Democratic Republic of the Congo (DRC) and constitute a serious public health problem. As recommended by the World Health Organization (WHO), before launching mass chemotherapy to control these diseases, parasitological surveys were conducted in sentinel sites in six health zones (HZs) in Bandundu and Maniema provinces. Baseline prevalence and intensity of infection for SCH and STH were determined to establish the appropriate treatment plan using Praziquantel (PZQ) and Albendazole (ALB)...
November 22, 2016: Acta Tropica
https://www.readbyqxmd.com/read/27881115/intestinal-polyparasitism-with-special-emphasis-to-soil-transmitted-helminths-among-residents-around-gilgel-gibe-dam-southwest-ethiopia-a-community-based-survey
#5
Zeleke Mekonnen, Sultan Suleman, Abdissa Biruksew, Tamirat Tefera, Legese Chelkeba
BACKGROUND: One third of the world population is estimated to be infected with intestinal parasites. The most affected people are children and the poor people living in tropics and subtropics. Polyparasitism (the concurrent infection with multiple intestinal parasite species) is found to be the norm among the same population although accurate estimate of its magnitude is unknown. It was found that polyparasitism might have a greater impact on morbidity than single species infection which might also increase susceptibility to other infections...
November 23, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27853115/prehistoric-pathoecology-as-represented-by-parasites-of-a-mummy-from-the-perua%C3%A3-u-valley-brazil
#6
REVIEW
Karl J Reinhard, Adauto Araújo
Paleopathologists have begun exploring the pathoecology of parasitic diseases in relation to diet and environment. We are summarizing the parasitological findings from a mummy in the site of Lapa do Boquete, a Brazilian cave in the state of Minas Gerais. These findings in context of the archaeology of the site provided insights into the pathoecology of disease transmission in cave and rockshelter environments. We are presenting a description of the site followed by the evidence of hookworm, intestinal fluke, and Trypanosoma infection with resulting Chagas disease in the mummy discovered in the cave...
October 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/27827838/the-proportion-of-anemia-associated-with-iron-deficiency-in-low-medium-and-high-human-development-index-countries-a-systematic-analysis-of-national-surveys
#7
REVIEW
Nicolai Petry, Ibironke Olofin, Richard F Hurrell, Erick Boy, James P Wirth, Mourad Moursi, Moira Donahue Angel, Fabian Rohner
Iron deficiency is commonly assumed to cause half of all cases of anemias, with hereditary blood disorders and infections such as hookworm and malaria being the other major causes. In countries ranked as low, medium, and high by the Human Development Index, we conducted a systematic review of nationally representative surveys that reported the prevalence of iron deficiency, iron deficiency anemia, and anemia among pre-school children and non-pregnant women of reproductive age. Using random effects meta-analyses techniques, data from 23 countries for pre-school children and non-pregnant women of reproductive age was pooled, and the proportion of anemia attributable to iron deficiency was estimated by region, inflammation exposure, anemia prevalence, and urban/rural setting...
November 2, 2016: Nutrients
https://www.readbyqxmd.com/read/27827438/changes-in-duodenal-tissue-associated-microbiota-following-hookworm-infection-and-consecutive-gluten-challenges-in-humans-with-coeliac-disease
#8
Paul Giacomin, Martha Zakrzewski, Timothy P Jenkins, Xiaopei Su, Rafid Al-Hallaf, John Croese, Stefan de Vries, Andrew Grant, Makedonka Mitreva, Alex Loukas, Lutz Krause, Cinzia Cantacessi
A reduced diversity of the gastrointestinal commensal microbiota is associated with the development of several inflammatory diseases. Recent reports in humans and animal models have demonstrated the beneficial therapeutic effects of infections by parasitic worms (helminths) in some inflammatory disorders, such as inflammatory bowel disease (IBD) and coeliac disease (CeD). Interestingly, these studies have described how helminths may alter the intestinal microbiota, potentially representing a mechanism by which they regulate inflammation...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27822385/intestinal-schistosomiasis-among-primary-schoolchildren-in-two-on-shore-communities-in-rorya-district-northwestern-tanzania-prevalence-intensity-of-infection-and-associated-risk-factors
#9
David Z Munisi, Joram Buza, Emmanuel A Mpolya, Safari M Kinung'hi
In Tanzania, Schistosoma mansoni is of great public health importance. Understanding the prevalence and infection intensity is important for targeted, evidence-based control strategies. This study aimed at studying the prevalence, intensity, and risk factors of S. mansoni among schoolchildren in the study area. A cross-sectional study was conducted in Busanga and Kibuyi villages. Sampled 513 schoolchildren provided stool specimens which were examined using kato-katz method. Pretested questionnaire was used to collect sociodemographic data and associated risk factors...
2016: Journal of Parasitology Research
https://www.readbyqxmd.com/read/27821692/combining-footwear-with-public-health-iconography-to-prevent-soil-transmitted-helminth-infections
#10
Sarah B Paige, Sagan Friant, Lucie Clech, Carly Malavé, Catherine Kemigabo, Richard Obeti, Tony L Goldberg
Shoes are effective for blocking soil-transmitted helminths (STHs) that penetrate the skin. Unfortunately, shoe-wearing is uncommon in many areas where STHs are prevalent, in part because local populations are unaware of the health benefits of wearing shoes. This is especially true in low-literacy populations, where information dissemination through written m essages is not possible. We launched a public health intervention that combines a public health image with sandals. The image is a "lenticular image" that combines two alternating pictures to depict the efficacy of shoes for preventing STH infection...
November 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27806046/migrant-workers-in-malaysia-current-implications-of-sociodemographic-and-environmental-characteristics-in-the-transmission-of-intestinal-parasitic-infections
#11
Norhidayu Sahimin, Yvonne A L Lim, Farnaza Ariffin, Jerzy M Behnke, John W Lewis, Siti Nursheena Mohd Zain
A cross-sectional study of intestinal parasitic infections amongst migrant workers in Malaysia was conducted. A total of 388 workers were recruited from five sectors including manufacturing, construction, plantation, domestic and food services. The majority were recruited from Indonesia (n = 167, 43.3%), followed by Nepal (n = 81, 20.9%), Bangladesh (n = 70, 18%), India (n = 47, 12.1%) and Myanmar (n = 23, 5.9.2%). A total of four nematode species (Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis and hookworms), one cestode (Hymenolepis nana) and three protozoan species (Entamoeba histolytica/dispar, Giardia sp...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27797959/hookworm-recombinant-protein-promotes-regulatory-t-cell-responses-that-suppress-experimental-asthma
#12
Severine Navarro, Darren A Pickering, Ivana B Ferreira, Linda Jones, Stephanie Ryan, Sally Troy, Andrew Leech, Peter J Hotez, Bin Zhan, Thewarach Laha, Roger Prentice, Tim Sparwasser, John Croese, Christian R Engwerda, John W Upham, Valerie Julia, Paul R Giacomin, Alex Loukas
In the developed world, declining prevalence of some parasitic infections correlates with increased incidence of allergic and autoimmune disorders. Moreover, experimental human infection with some parasitic worms confers protection against inflammatory diseases in phase 2 clinical trials. Parasitic worms manipulate the immune system by secreting immunoregulatory molecules that offer promise as a novel therapeutic modality for inflammatory diseases. We identify a protein secreted by hookworms, anti-inflammatory protein-2 (AIP-2), that suppressed airway inflammation in a mouse model of asthma, reduced expression of costimulatory markers on human dendritic cells (DCs), and suppressed proliferation ex vivo of T cells from human subjects with house dust mite allergy...
October 26, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27793110/effect-of-anthelminthic-treatment-on-helminth-infection-and-related-anaemia-among-school-age-children-in-northwestern-ethiopia
#13
Yonas Yimam, Abraham Degarege, Berhanu Erko
BACKGROUND: Information about improvements in the health status of population at-risk of helminth infection after anthelminthic treatment helps to evaluate the effectiveness of the large scale deworming program. The objectives of this study were to assess the impact of anthelminthic treatment on the prevalence and intensity of intestinal helminth infection, haemoglobin level and prevalence of anaemia among school-age children. METHODS: A total of 403 children attending Tikur Wuha Elementary School in Jiga, northwestern Ethiopia were enrolled in this study between February and March 2011...
October 28, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27790963/comparison-between-merthiolate-iodine-formalin-and-kato-katz-methods-for-the-diagnosis-of-human-helminth-infections-in-resource-limited-settings
#14
R N Incani, T Homan, E Pinelli, L Mughini-Gras, H Guevara, J Jesus
Diagnosis of intestinal parasites through examination of fresh faecal samples is hampered by its unpleasantness and the urgent need to detect all parasitic forms. In this paper, we compared the standard Kato-Katz (KK) technique with a traditional fixation method, the merthiolate-iodine-formalin (MIF) method. Two hundred and twenty-seven faecal samples from individuals living in a rural setting in Venezuela with high to moderate prevalences of Ascaris lumbricoides (Al), Trichuris trichiura (Tt) and hookworm infections were examined...
October 28, 2016: Journal of Helminthology
https://www.readbyqxmd.com/read/27771803/efficacy-against-nematode-infections-and-safety-of-afoxolaner-plus-milbemycin-oxime-chewable-tablets-in-domestic-dogs-under-field-conditions-in-europe
#15
Steffen Rehbein, Martin Knaus, Yasmina Mallouk, Tatjana Breiltgens, Emanuele Brianti, Balázs Capári, Filipe Dantas-Torres, Michel Gau, Anja Joachim, Karl-Heinz Kaulfuß, Zvezdelina Kirkova, Joerg Lechner, Andrei D Mihalca, Rosamaria Mirabito, Saulius Petkevičius, Dhimitër Rapti, Enstela Shukullari, Michel Sedeilhan, Doris Dollhofer, Katrin Kley, Wilfried Lebon, Martin Visser, Philippe Jeannin
Afoxolaner (AFX) plus milbemycin oxime (MO) combination chewable tablets (NexGard Spectra®, Merial) were evaluated for safety and efficacy against naturally acquired nematode infections in domestic dogs in a multi-centre, positive control, blinded field study using a randomized block design based on the order of presentation for allocation. In total, 408 dogs confirmed positive for naturally acquired infections of intestinal nematodes by pre-treatment faecal examination were studied in ten countries in Europe (Albania, Austria, Bulgaria, France, Germany, Hungary, Italy, Lithuania, Romania and Slovakia)...
October 22, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27751868/microfluidic-platform-for-electrophysiological-recordings-from-host-stage-hookworm-and-ascaris-suum-larvae-a-new-tool-for-anthelmintic-research
#16
Janis C Weeks, William M Roberts, Kristin J Robinson, Melissa Keaney, Jon J Vermeire, Joseph F Urban, Shawn R Lockery, John M Hawdon
The screening of candidate compounds and natural products for anthelmintic activity is important for discovering new drugs against human and animal parasites. We previously validated in Caenorhabditis elegans a microfluidic device ('chip') that records non-invasively the tiny electrophysiological signals generated by rhythmic contraction (pumping) of the worm's pharynx. These electropharyngeograms (EPGs) are recorded simultaneously from multiple worms per chip, providing a medium-throughput readout of muscular and neural activity that is especially useful for compounds targeting neurotransmitter receptors and ion channels...
September 15, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27738113/evolution-of-the-prevalence-of-intestinal-parasitic-infections-among-the-french-armed-forces-in-french-guiana
#17
Jacques-Robert Christen, Marie Mura, Gwenaëlle Roudaut, Anne-Sophie Drogoul, Magalie Demar, Sébastien Briolant, Eric Garnotel, Fabrice Simon, Vincent Pommier De Santi
Two cross-sectional studies were performed 2 years apart in French military personnel deployed from France to French Guiana. In 2011, military medical centres in French Guiana reported 40 cases of intestinal parasitism in service members returning from illegal gold mining sites in the rainforest. In 2013, 48 out of 132 service members returning from French Guiana after a 4-month mission had eosinophilia and seven were infected with hookworm. A presumptive first-line treatment with albendazole could be the most pragmatic strategy...
July 2016: Journal of Travel Medicine
https://www.readbyqxmd.com/read/27724979/intestinal-parasite-infections-and-associated-risk-factors-in-communities-exposed-to-wastewater-in-urban-and-peri-urban-transition-zones-in-hanoi-vietnam
#18
Samuel Fuhrimann, Mirko S Winkler, Phuc Pham-Duc, Dung Do-Trung, Christian Schindler, Jürg Utzinger, Guéladio Cissé
BACKGROUND: Infections with intestinal parasites (helminths and intestinal protozoa) are endemic in Southeast Asia and inappropriate management and reuse of wastewater might exacerbate the risk of human infections. In rapidly growing urban settings, little is known about the extent of intestinal parasite infections. We assessed the point-prevalence and risk factors of intestinal parasite infections in population groups differently exposed to wastewater in urban and peri-urban transition zones in Hanoi, the capital of Vietnam...
October 10, 2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27717859/risk-factors-for-human-helminthiases-in-rural-philippines
#19
Allen G P Ross, Remigio M Olveda, Donald P McManus, Donald A Harn, Delia Chy, Yuesheng Li, Veronica Tallo, Shu-Kay Ng
BACKGROUND: A cross-sectional survey was performed in 2012 among 18 rural barangays in Northern Samar, the Philippines in order to determine the prevalence of single and multiple species helminth infections and the underlying risk factors of acquiring one or more parasites. METHODS: A total of 6976 participants who completed a medical questionnaire and provided a stool sample for examination were included in the final analysis. RESULTS: The overall prevalence rates of Schistosoma japonicum, Ascaris lumbricoides, Trichuris trichiura, and hookworm were found to be moderate to high at 28...
October 4, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27716099/prevalence-of-intestinal-parasitic-infections-and-associated-risk-factors-among-pregnant-women-attending-antenatal-care-center-at-felege-hiwot-referral-hospital-northwest-ethiopia
#20
Adane Derso, Endalkachew Nibret, Abaineh Munshea
BACKGROUND: Parasitic infections affect tens of millions of pregnant women worldwide, and directly or indirectly lead to a spectrum of adverse maternal and fetal/placental effects. The objective of this study was to assess the prevalence of intestinal parasite infections and associated risk factors among pregnant women attending antenatal care center in Felege Hiwot Referral Hospital, Bahir Dar city, northwest Ethiopia. METHODS: A cross-sectional hospital based study was conducted from November 2013 to January 2014 among 384 pregnant women...
September 30, 2016: BMC Infectious Diseases
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