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https://www.readbyqxmd.com/read/28100811/the-molecular-speciation-of-soil-transmitted-helminth-eggs-collected-from-school-children-across-six-endemic-countries
#1
Santosh George, Peter Geldhof, Marco Albonico, Shaali M Ame, Jeffrey M Bethony, Dirk Engels, Zeleke Mekonnen, Antonio Montresor, Sopheak Hem, Louis-Albert Tchuem-Tchuenté, Nguyen Thu Huong, Gagandeep Kang, Jozef Vercruysse, Bruno Levecke
BACKGROUND: The diagnosis of soil-transmitted helminths (STHs; Ascaris, Trichuris and hookworms) is traditionally based on the demonstration of eggs in stool using microscopic techniques. While molecular techniques are more appropriate to speciate STH species they are seldom applied. In this study we speciated STH eggs from stool using molecular techniques to gain insights into the distribution of both human and animal STH species in the human host. METHODS: We speciated 207 STH egg isolates from stool collected during the baseline survey of six drug efficacy trials conducted in Brazil, Cambodia, Cameroon, Ethiopia, Tanzania and Vietnam applying a PCR - restriction fragment length polymorphisms based approach...
January 18, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28098549/diffuse-unilateral-subacute-neuroretinitis-caused-by-ancylostoma-hookworm
#2
Sven Poppert, Martin Heideking, Hansjürgen Agostini, Moritz Fritzenwanker, Nicole Wüppenhorst, Birgit Muntau, Philipp Henneke, Winfried Kern, Jürgen Krücken, Bernd Junker, Markus Hufnagel
Diffuse unilateral subacute neuroretinitis is an ocular infectious disease caused by several distinct nematodes. Definite identification of the involved nematodes is rarely achieved. We report on the molecular-based genetic identification of an Ancylostoma ceylanicum hookworm implicated in a case of diffuse unilateral subacute neuroretinitis in a child.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28098526/ancylostoma-ceylanicum-hookworm-in-the-solomon-islands
#3
Richard S Bradbury, Sze Fui Hii, Humpress Harrington, Richard Speare, Rebecca Traub
Although hookworm is highly prevalent in the Solomon Islands, the species involved are unknown. We initiated this study in response to finding Ancylostoma ceylanicum hookworm in a peacekeeper in Australia who had returned from the Solomon Islands. Kato-Katz fecal surveys performed in 2013 and 2014 in 2 village groups in East Malaita, Solomon Islands, identified hookworm-positive samples. These specimens were tested by cytochrome oxidase 1 (cox-1) gene multiplex PCR and sequenced. Of 66 positive specimens, 54 (81...
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28095659/molecular-characterization-of-nippostrongylus-brasiliensis-nematoda-heligmosomatidae-from-mus-musculus-in-india
#4
Anshu Chaudhary, Urvashi Goswami, Hridaya Shanker Singh
Mus musculus (Rodentia: Muridae) has generally been infected with a rodent hookworm Nippostrongylus brasiliensis. In this report, we present morphological and molecular identification of N. brasiliensis by light and scanning electron microscopy and PCR amplification of mitochondrial cytochrome c oxidase subunit 1 (cox1) gene and the protein sequences encoded by cox1 gene, respectively. Despite the use of N. brasiliensis in many biochemistry studies from India, their taxonomic identification was not fully understood, especially at the species level, and no molecular data is available in GenBank from India...
December 2016: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28091387/prevalence-of-intestinal-parasites-in-cats-and-their-importance-in-terms-of-public-health
#5
Umut Fikret Korkmaz, Sami Gökpınar, Kader Yıldız
OBJECTIVE: This study aimed to detect the prevalence of intestinal parasites in cats by fecal examination. METHODS: A total of 100 fecal samples were collected from owned and stray cats in the Kırıkkale province. Epidemiological data on the sampled cats (e.g., age, race, and sex) were recorded. The samples were macroscopically investigated for the presence of cestode proglottids. The fecal smears were stained with Giemsa and Carbol fuchsin stains. The samples were prepared by centrifugal flotation with a saturated sugar solution...
December 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28080916/aerobic-microflora-and-endoparasites-of-freshly-shot-wild-agouti-dasyprocta-leporina-in-trinidad-west-indies
#6
Rod Suepaul, Roxanne Charles, Francis Dziva
The agouti ( Dasyprocta leporina ) is a New World wild rodent hunted for its meat in Trinidad and other Latin American countries. Studies on agouti under captive conditions have yielded some data on health-related aspects, but relatively very little is known about their wild counterparts. The environment of the agouti can influence the microflora and parasites harbored by the animals, which may contain zoonotic pathogens. Here, the microflora found on the nasal mucosa and sections of the intestinal tract and endoparasites of freshly shot agouti from various areas of Trinidad are described...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28078983/cutaneous-larva-migrans
#7
Alexander K C Leung, Benjamin Barankin, Kam Lun Hon
BACKGROUND: Cutaneous larva migrans is one of the most common skin diseases reported in travelers returning from tropical regions. Western physicians, however, are often not familiar of this condition. OBJECTIVE: To review in depth the epidemiology, pathophysiology, clinical manifestations, complications, and treatment of cutaneous larva migrans. METHODS: A PubMed search was completed in Clinical Queries using the key term "cutaneous larva migrans"...
January 10, 2017: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/28077747/first-molecular-identifications-of-necator-americanus-and-ancylostoma-ceylanicum-infecting-rural-communities-in-lower-myanmar
#8
Win Pa Pa Aung, Thi Thi Htoon, Htay Htay Tin, Oranuch Sanpool, Jurairat Jongthawin, Lakkhana Sadaow, Issarapong Phosuk, Rutchanee Ropai, Pewpan M Intapan, Wanchai Maleewong
Hookworms are enteric parasitic roundworms infecting an estimated 400 million persons worldwide. Herein, we provide the first molecular identifications of human hookworms from certain parts of rural Lower Myanmar. DNA was extracted from hookworm-positive stool samples, as determined by microscopy. DNA sequences of the partial internal transcribed spacer 1, full length 5.8S gene, and partial internal transcribed spacer 2 were determined and compared with available hookworm sequences from public databases. Of the 11 polymerase chain reaction-positive samples, eight (Bago Region, N = 4; Mon State, N = 4) yielded sequences with high similarity to those of Necator americanus A further three sequences (Mon State, N = 2; Bago Region, N = 1) showed high similarity with those of Ancylostoma ceylanicum The latter is primarily a parasite of dogs and represents a zoonosis...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28057071/parasitic-infections-and-maternal-anaemia-among-expectant-mothers-in-the-dangme-east-district-of-ghana
#9
Samuel Crowther Kofi Tay, Emmanuel Agbeko Nani, Williams Walana
BACKGROUND: Parasitic infections are of public health concern globally, particular among at risk groups such as pregnant women in developing countries. The presence of these parasites during pregnancy potentiate adverse effects to both the mother and the unborn baby. This study sought to establish the prevalence of some parasitic agents among antenatal attendees in the Dangme East District of Ghana. A cross-sectional prospective study was conduct between April and July, 2012. Venous blood specimens were collected from each participant for haemoglobin estimation and malaria microscopy...
January 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056024/a-double-blind-randomized-controlled-trial-of-maternal-postpartum-deworming-to-improve-infant-weight-gain-in-the-peruvian-amazon
#10
Layla S Mofid, Martín Casapía, Eder Aguilar, Hermánn Silva, Antonio Montresor, Elham Rahme, William D Fraser, Grace S Marquis, Jozef Vercruysse, Lindsay H Allen, Brittany Blouin, Hugo Razuri, Lidsky Pezo, Theresa W Gyorkos
BACKGROUND: Nutritional interventions targeting the critical growth and development period before two years of age can have the greatest impact on health trajectories over the life course. Compelling evidence has demonstrated that interventions investing in maternal health in the first 1000 days of life are beneficial for both mothers and their children. One such potential intervention is deworming integrated into maternal postpartum care in areas where soil-transmitted helminth (STH) infections are endemic...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27988408/risk-of-human-helminthiases-geospatial-distribution-and-targeted-control
#11
Weiwei Yu, Allen G Ross, Remigio M Olveda, Donald A Harn, Yuesheng Li, Delia Chy, Gail M Williams
OBJECTIVES: We conducted a cross-sectional survey in 2012 among 22 rural barangays in Northern Samar, the Philippines in order to determine the prevalence of single and multiple species helminth infections, their geospatial distribution and underlying risk factors. METHODS: A total of 10,434 individuals who had completed both a medical questionnaire and a stool examination were included in the analysis. Barangay specific prevalence rates were displayed in ArcMap...
December 14, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27979381/differential-effect-of-mass-deworming-and-targeted-deworming-for-soil-transmitted-helminth-control-in-children-a-systematic-review-and-meta-analysis
#12
Naomi E Clarke, Archie C A Clements, Suhail A Doi, Dongxu Wang, Suzy J Campbell, Darren Gray, Susana V Nery
BACKGROUND: Soil-transmitted helminth infections are a major global health issue, causing substantial morbidity in the world's poorest populations. Regular delivery of anthelmintic drugs is the mainstay for global soil-transmitted helminth control. Deworming campaigns are often targeted to school-aged children, who are at high risk of soil-transmitted-helminth-associated morbidity. However, findings from modelling studies suggest that deworming campaigns should be expanded community-wide for effective control of soil-transmitted helminth transmission...
December 12, 2016: Lancet
https://www.readbyqxmd.com/read/27978433/exploiting-old-pathogens-to-create-new-therapeutics
#13
Tiffany Bouchery, Nicola L Harris
Intestinal worms are well known for their potent immuno-modulatory capacity. In a recent study, Navarro et al. (2016) identify a secreted hookworm protein that can suppress allergic responses in both mice and humans. This represents an exciting strategy for treating chronic inflammatory disorders such as allergy.
December 14, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27955788/mass-deworming-to-improve-developmental-health-and-wellbeing-of-children-in-low-income-and-middle-income-countries-a-systematic-review-and-network-meta-analysis
#14
Vivian A Welch, Elizabeth Ghogomu, Alomgir Hossain, Shally Awasthi, Zulfiqar A Bhutta, Chisa Cumberbatch, Robert Fletcher, Jessie McGowan, Shari Krishnaratne, Elizabeth Kristjansson, Salim Sohani, Shalini Suresh, Peter Tugwell, Howard White, George A Wells
BACKGROUND: Soil-transmitted helminthiasis and schistosomiasis, considered among the neglected tropical diseases by WHO, affect more than a third of the world's population, with varying intensity of infection. We aimed to evaluate the effects of mass deworming for soil-transmitted helminths (with or without deworming for schistosomiasis or co-interventions) on growth, educational achievement, cognition, school attendance, quality of life, and adverse effects in children in endemic helminth areas...
January 2017: Lancet Global Health
https://www.readbyqxmd.com/read/27936031/schistosoma-mansoni-infections-undernutrition-and-anaemia-among-primary-schoolchildren-in-two-onshore-villages-in-rorya-district-north-western-tanzania
#15
David Zadock Munisi, Joram Buza, Emmanuel A Mpolya, Safari M Kinung'hi
BACKGROUND: Undernutrition and anaemia remains to be a major public health problem in many developing countries, where they mostly affect children. Intestinal parasitic infections are known to affect both growth and haemoglobin levels. Much has been reported on the impact of geohelminths on anaemia and undernutrition, leaving that of Schistosoma mansoni not well studied. Therefore this study intended to determine the association between S.mansoni infections, anaemia and undernutrition among schoolchildren in Rorya district, Northwestern Tanzania...
2016: PloS One
https://www.readbyqxmd.com/read/27930648/isothermal-diagnostic-assays-for-monitoring-single-nucleotide-polymorphisms-in-necator-americanus-associated-with-benzimidazole-drug-resistance
#16
Nour Rashwan, Catherine Bourguinat, Kathy Keller, Nipul Kithsiri Gunawardena, Nilanthi de Silva, Roger Prichard
BACKGROUND: Soil-transmitted helminths (STHs) are the most prevalent intestinal helminths of humans, and a major cause of morbidity in tropical and subtropical countries. The benzimidazole (BZ) drugs albendazole (ABZ) and mebendazole (MBZ) are used for treatment of human STH infections and this use is increasing dramatically with massive drug donations. Frequent and prolonged use of these drugs could lead to the emergence of anthelmintic resistance as has occurred in nematodes of livestock...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27929101/hookworm-infection
#17
Alex Loukas, Peter J Hotez, David Diemert, Maria Yazdanbakhsh, James S McCarthy, Rodrigo Correa-Oliveira, John Croese, Jeffrey M Bethony
Hookworms are soil-transmitted nematode parasites that can reside for many years in the small intestine of their human hosts; Necator americanus is the predominant infecting species. Adult worms feed on the blood of a host and can cause iron deficiency anaemia, especially in high-risk populations (children and women of childbearing age). Almost 500 million people in developing tropical countries are infected, and simulation models estimate that hookworm infection is responsible for >4 million disability-adjusted life years lost annually...
December 8, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27929029/hookworm-infection
#18
(no author information available yet)
No abstract text is available yet for this article.
December 8, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27923048/contribution-of-wastewater-irrigation-to-soil-transmitted-helminths-infection-among-vegetable-farmers-in-kumasi-ghana
#19
Isaac Dennis Amoah, Amina Abubakari, Thor Axel Stenström, Robert Clement Abaidoo, Razak Seidu
Wastewater irrigation is associated with several benefits but can also lead to significant health risks. The health risk for contracting infections from Soil Transmitted Helminths (STHs) among farmers has mainly been assessed indirectly through measured quantities in the wastewater or on the crops alone and only on a limited scale through epidemiological assessments. In this study we broadened the concept of infection risks in the exposure assessments by measurements of the concentration of STHs both in wastewater used for irrigation and the soil, as well as the actual load of STHs ova in the stool of farmers and their family members (165 and 127 in the wet and dry seasons respectively) and a control group of non-farmers (100 and 52 in the wet and dry seasons, respectively)...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27903301/high-prevalence-of-strongyloides-stercoralis-in-school-aged-children-in-a-rural-highland-of-north-western-ethiopia-the-role-of-intensive-diagnostic-work-up
#20
Aranzazu Amor, Esperanza Rodriguez, José M Saugar, Ana Arroyo, Beatriz López-Quintana, Bayeh Abera, Mulat Yimer, Endalew Yizengaw, Derejew Zewdie, Zimman Ayehubizu, Tadesse Hailu, Wondemagegn Mulu, Adriana Echazú, Alejandro J Krolewieki, Pilar Aparicio, Zaida Herrador, Melaku Anegagrie, Agustín Benito
BACKGROUND: Soil-transmitted helminthiases (hookworms, Ascaris lumbricoides and Trichuris trichiura) are extremely prevalent in school-aged children living in poor sanitary conditions. Recent epidemiological data suggest that Strongyloides stercoralis is highly unreported. However, accurate data are essential for conducting interventions aimed at introducing control and elimination programmes. METHODS: We conducted a cross-sectional survey of 396 randomly selected school-aged children in Amhara region in rural area in north-western Ethiopia, to assess the prevalence of S...
December 1, 2016: Parasites & Vectors
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