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Upper tract urothelial carcinoma

Sarah Mozafarpour, Natalia Hernandez, Michael Lipkin, Brian Eisner
Over the past 2 decades, ureteroscopy has changed from a procedure considered second-line to shockwave lithotripsy to a commonly performed procedure for renal and ureteral stones. The increase in the use of ureteroscopy is due largely to improvements in technique and technology during this time period. Herein we review outcomes of ureteroscopy in terms of success rates, complications, and unique patient populations. This work will synthesize the data as it pertains to the practice of ureteroscopy for all endourological indications, including stone disease and management of upper tract urothelial carcinoma, as well as review state-of-the-art techniques...
October 12, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Orietta Dalpiaz, Daniel Krieger, Georg C Ehrlich, Kristof Pohlmann, Tatjana Stojakovic, Karl Pummer, Richard Zigeuner, Martin Pichler, Georg C Hutterer
INTRODUCTION: This study is aimed at investigating the potential prognostic impact of the preoperatively assessed platelet-to-lymphocyte ratio (PLR) in a European cohort of patients with non-metastatic upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: Clinicopathological data from 180 consecutive non-metastatic UTUC patients, operated between 1990 and 2012 at a single tertiary academic center, were evaluated retrospectively. The preoperative PLR was assessed one day before surgery...
October 13, 2016: Urologia Internationalis
G J Wirth, A Haitel, M Moschini, F Soria, T Klatte, M R Hassler, K Bensalah, A Briganti, J A Karam, Y Lotan, V Margulis, J D Raman, M Remzi, N Rioux-Leclercq, B D Robinson, M Rouprêt, C G Wood, S F Shariat
PURPOSE: This study aims to determine the significance of androgen receptor (AR) expression in urothelial carcinoma of the upper urinary tract (UTUC). METHODS: AR expression was assessed on tissue microarrays containing specimens of 737 patients with UTUC who underwent radical nephroureterectomy with curative intent. AR expression was correlated with clinical and pathological tumor features as well as recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS)...
October 11, 2016: World Journal of Urology
Chi-Cheng Chen, Chi-Ping Huang, Teng-Fu Hsieh, Wei-Kai Chiu, Wen-Ling Chang, Chih-Rong Shyr
Interactions between infiltrating macrophages in the tumor microenvironment (TME) and tumor cells contribute to tumor progression. The potential impacts of recruited macrophages to the upper urinary tract urothelial cell carcinomas (UUTUCs) progression remain unclear. Here we found human UUTUCs might recruit more macrophages than surrounding normal urothelial cells in human clinical specimens and in in vitro co-culture experiments with UUTUC cells and macrophages. The consequences of recruiting more macrophages to UUTUCs might then enhance UUTUC cell growth, migration and invasion...
2016: American Journal of Cancer Research
Jian Cao, Xiaokun Zhao, Zhaohui Zhong, Lei Zhang, Xuan Zhu, Ran Xu
The effect of pre-operative renal insufficiency on urothelial carcinoma (UC) prognosis has been investigated by numerous studies. While the majority report worse UC outcomes in patients with renal insufficiency, the results between the studies differed wildly. To enable us to better estimate the prognostic value of renal insufficiency on UC, we performed a systematic review and meta-analysis based on the published literature. A total of 16 studies which involved 5,232 patients with UC, investigated the relationship between pre-operative renal insufficiency and disease prognosis...
October 11, 2016: Scientific Reports
Gilhyang Kim, Yul Ri Chung, Bohyun Kim, Boram Song, Kyung Chul Moon
Background: Human epidermal growth factor receptor 2 (HER2) is one of the known oncogenes in urothelial carcinoma. However, the association between HER2 and the prognosis of upper urinary tract urothelial carcinoma (UUTUC) has not yet been fully clarified. The aim of this study was to evaluate HER2 expression using the United States Food and Drug Administration (FDA) criteria and American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) criteria and compare their prognostic significance in UUTUC...
October 10, 2016: Journal of Pathology and Translational Medicine
Georgios Gakis, Peter C Black, Bernard H Bochner, Stephen A Boorjian, Arnulf Stenzl, George N Thalmann, Wassim Kassouf
CONTEXT: Urothelial carcinoma is considered a pan-urothelial disease. As such, the remnant urothelium in the upper urinary tract and urethra following radical cystectomy (RC) remains at risk for secondary urothelial tumors (SUTs). OBJECTIVE: To describe the incidence, diagnosis, treatment, and outcomes of patients with SUTs after RC. EVIDENCE ACQUISITION: A systematic search was conducted using PubMed database according to Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to identify studies between 1970 and 2016 reporting on malignant diseases of the urothelium after RC for bladder cancer...
October 6, 2016: European Urology
Holly L Harper, Jesse K McKenney, Brandie Heald, Andrew Stephenson, Steven C Campbell, Thomas Plesec, Cristina Magi-Galluzzi
Increased risk for upper tract urothelial carcinoma is described in patients with Lynch syndrome, caused by germline mutations in mismatch repair genes. We aimed to identify the frequency of mismatch repair protein loss in upper tract urothelial carcinoma and its potential for identifying an association with Lynch syndrome. We queried our database to identify upper tract urothelial carcinomas. Patients were cross-referenced for history of colorectal carcinoma or other common Lynch syndrome-associated neoplasms to enrich for potential Lynch syndrome cases...
October 7, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Hiroaki Matsumoto, Masaru Munemori, Kosuke Shimizu, Nakanori Fujii, Keita Kobayashi, Ryo Inoue, Yoshiaki Yamamoto, Kazuhiro Nagao, Hideyasu Matsuyama
OBJECTIVES: To investigate the expression levels of E-cadherin, Snail, Twist and Bmi-1 in the human upper tract urothelial carcinoma, and to assess whether these factors could be prognostic markers. METHODS: Immunohistochemistry was carried out to determine the expression of E-cadherin, Snail, Twist and Bmi-1 in upper tract urothelial carcinoma samples from 144 patients that underwent total nephroureterectomy between January 1995 and December 2010. The patient population had a median age of 71 years, and comprised 104 men and 40 women, with a median follow-up period of 40 months...
October 5, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
Pavlos Msaouel, Miao Zhang, Shi-Ming Tu
No abstract text is available yet for this article.
September 7, 2016: Clinical Genitourinary Cancer
Xiao Yang, Peng Li, Xiaheng Deng, Hongquan Dong, Yidong Cheng, Xiaolei Zhang, Chengdi Yang, Jingyuan Tang, Wenbo Yuan, Xiaoting Xu, Jun Tao, Pengchao Li, Haiwei Yang, Qiang Lu, Min Gu, Zengjun Wang
BACKGROUND: Perioperative treatments have been used to improve prognosis in patients with upper tract urothelial carcinoma (UTUC). However, optimal management remains unestablished. METHODS: We searched the Embase, Web of Science and Cochrane databases for studies published before June 20, 2015. All included studies were categorised into three groups on the basis of the outcome reported (overall survival (OS), disease-specific survival (DSS) and recurrence-free survival (RFS))...
September 24, 2016: Oncotarget
Laura-Maria Krabbe, Okyaz Eminaga, Shahrokh F Shariat, Ryan C Hutchinson, Yair Lotan, Arthur I Sagalowsky, Jay D Raman, Christopher G Wood, Alon Z Weizer, Marco Roscigno, Francesco Montorsi, Christian Bolenz, Giacomo Novara, Eiji Kikuchi, Harun Fajkovic, Leonid M Rapoport, Peter V Glybochko, Richard Zigeuner, Mesut Remzi, Karim Bensalah, Wassim Kassouf, Vitaly Margulis
PURPOSE: To develop a prognostic nomogram after extirpative for patients with high-grade UTUC. MATERIALS AND METHODS: Clinical data were available for 2,926 patients diagnosed with high-grade UTUC who underwent extirpative surgery. Cox proportional hazard regression models identified independent prognosticators of relapse in the development cohort (n=838). A backward step-down selection process was applied to achieve the most informative nomogram with the least number of variables...
September 23, 2016: Journal of Urology
Grant P Redrow, Charles C Guo, Maurizio A Brausi, Jonathan A Coleman, Mario I Fernandez, Wassim Kassouf, Francis X Keeley, Vitaly Margulis, Jay D Raman, Morgan Roupret, Shahrokh F Shariat, Philippe E Spiess, George N Thalmann, Surena F Matin
PURPOSE: Carcinoma in situ of the urinary tract is a high-grade form of non-muscle invasive urothelial carcinoma, with poor understanding of this entity in the upper tract (UTCIS). Patient management remains challenging due to knowledge gaps regarding the definition, diagnosis, treatment options, and follow up of disease. We review the available literature for similarities and differences between bladder and upper tract CIS summarizing the best available data. MATERIALS AND METHODS: Thorough review of PubMed and MEDLINE databases was performed from January 1976 through September 2014...
September 21, 2016: Journal of Urology
Eiji Kashiwagi, Kazutoshi Fujita, Seiji Yamaguchi, Hiroaki Fushimi, Hiroki Ide, Satoshi Inoue, Taichi Mizushima, Leonardo O Reis, Rajni Sharma, George J Netto, Norio Nonomura, Hiroshi Miyamoto
To assess the expression status of steroid hormone receptors in upper urinary tract urothelial carcinoma (UUTUC), we immunohistochemically stained for androgen receptor (AR), estrogen receptor-α (ERα), ERβ, glucocorticoid receptor (GR), and progesterone receptor (PR) in 99 UUTUC specimens and paired non-neoplastic urothelial tissues. AR/ERα/ERβ/GR/PR was positive in 20%/18%/62%/63%/16% of tumors, which was significantly lower (except PR) than in benign urothelial tissues [57% (P<0.001)/40% (P = 0.001)/85% (P = 0...
September 16, 2016: Cancer Biology & Therapy
Sara E Wobker, Manju Aron, Jonathan I Epstein
In the upper genitourinary tract of the ureter and renal pelvis, any invasion of urothelial carcinoma (UC) beyond the thin muscularis is considered pT3 disease, which may prompt adjuvant chemotherapy. Ureteroscopy is commonly used in the workup of these lesions to obtain tissue biopsies and cytology specimens, or to place stents for the relief of obstructive symptoms. The current study describes 4 cases in which the presence of small nests of urothelium in periureteral and peripelvic soft tissue was noted after ureteroscopic instrumentation, mimicking high-stage UC...
September 14, 2016: American Journal of Surgical Pathology
Nozomu Kishimoto, Tetsuya Takao, Sohei Kuribayashi, Gaku Yamamichi, Kosuke Nakano, Masataka Kawamura, Koichi Tsutahara, Go Tanigawa, Seiji Yamaguchi
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation associated with recurrence and poor prognosis in numerous cancer types. The aim of this study was to evaluate the use of the NLR as a biomarker for intravesical recurrence (IVR) in patients undergoing radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UTUC) for the first time. METHODS: We retrospectively analyzed the records of 100 patients with UTUC who had undergone RNU between 1999 and 2015 at our institution...
September 10, 2016: International Journal of Clinical Oncology
Hiroki Ide, Eiji Kikuchi, Masayuki Hagiwara, Nozomi Hayakawa, Hiroshi Hongo, Akira Miyajima, Mototsugu Oya
PURPOSE: Aromatic amines, well-known bladder carcinogens, derived from cigarette smoke are activated by acidic urine. We herein determined whether urinary pH levels are associated with bladder recurrence in upper tract urothelial carcinoma patients with a positive smoking history. METHODS: A total of 256 upper tract urothelial carcinoma patients who were surgically treated at our institution between 1990 and 2013 were included. Urinary pH levels were defined as the median of at least two consecutive measurements within 1 month of surgery...
September 9, 2016: Annals of Surgical Oncology
D Fang, T Seisen, K Yang, P Liu, X Fan, N Singla, G Xiong, L Zhang, X Li, L Zhou
OBJECTIVE: To perform a systematic review and meta-analysis of the comparative studies reporting oncological and renal function outcomes of segmental ureterectomy (SU) versus radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUC). MATERIALS AND METHODS: A literature search on Pubmed, Embase, and the Cochrane library was conducted according to the PRISMA guidelines, and a meta-analysis was performed to assess cancer-specific survival (CSS), overall survival (OS), recurrence-free survival (RFS), intravesical recurrence free survival (IVRFS) and surgery-related variations in estimated glomerular filtration rate (eGFR)...
August 25, 2016: European Journal of Surgical Oncology
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