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Upper tract urothelial carcinoma

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https://www.readbyqxmd.com/read/29444544/uridine-5-diphospho-glucuronosyltransferase-1a-expression-as-an-independent-prognosticator-in-urothelial-carcinoma-of-the-upper-urinary-tract
#1
Koji Izumi, Satoshi Inoue, Hiroki Ide, Kazutoshi Fujita, Taichi Mizushima, Guiyang Jiang, Seiji Yamaguchi, Hiroaki Fushimi, Norio Nonomura, Hiroshi Miyamoto
OBJECTIVE: To determine the expression status of uridine 5'diphospho-glucuronosyltransferase 1A, a major phase II drug metabolism enzyme, in upper urinary tract urothelial carcinoma, as well as to assess its prognostic significance. METHODS: We immunohistochemically stained for uridine 5'diphospho-glucuronosyltransferase 1A in tissue microarray consisting of 99 upper urinary tract urothelial carcinoma samples and paired non-neoplastic urothelial tissues. We also assessed the effect of uridine 5'diphospho-glucuronosyltransferase 1A knockdown on urothelial cancer cell growth...
February 14, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29436164/investigation-of-estimated-glomerular-filtration-rate-and-its-perioperative-change-in-patients-with-upper-urinary-tract-urothelial-carcinoma-a-multi-institutional-retrospective-study
#2
Dai Koguchi, Kazumasa Matsumoto, Masaomi Ikeda, Yoshinori Taoka, Takahiro Hirayama, Yasukiyo Murakami, Takuji Utsunomiya, Daisuke Matsuda, Norihiko Okuno, Akira Irie, Masatsugu Iwamura
AIM: To investigate the association of perioperative estimated glomerular filtration rate (eGFR) with prognosis in patients with upper urinary tract urothoelial caicinoma (UTUC). METHODS: A total of 433 patients underwent radical nephroureterectomy with excision of the bladder cuff (RNU) at six hospitals affiliated with Kitasato University in Japan. Patients were divided into three groups each in terms of preoperative eGFR: normal eGFR (>60 mL/min/1.73 m 2 ; n = 172), moderately reduced eGFR (45-60 mL/min/1...
February 12, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29435873/oncologic-outcomes-for-open-and-laparoscopic-radical-nephroureterectomy-in-patients-with-upper-tract-urothelial-carcinoma
#3
Koichi Kido, Shingo Hatakeyama, Naoki Fujita, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Ikuya Iwabuchi, Masaru Ogasawara, Toshiaki Kawaguchi, Chikara Ohyama
BACKGROUND: Oncologic benefits of laparoscopic radical nephroureterectomy (LNU) are unclear. We aimed to evaluate the impact of surgical approach for radical nephroureterectomy on oncologic outcomes in patients with locally advanced upper tract urothelial carcinoma (UTUC). METHODS: Of 426 patients who underwent radical nephroureterectomy at five medical centers between February 1995 and February 2017, we retrospectively investigated oncological outcomes in 229 with locally advanced UTUC (stages cT3-4 and/or cN+)...
February 12, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29435297/a-low-psoas-muscle-volume-predicts-longer-hospitalization-and-cancer-recurrence-in-upper-urinary-tract-urothelial-carcinoma
#4
Sohgo Tsutsumi, Takashi Kawahara, Jun-Ichi Teranishi, Masahiro Yao, Hiroji Uemura
The aging population is becoming a primary global problem. The most important alteration that occurs in the body with age, is the loss of skeletal muscle. Previously, sarcopenia, which is associated with the loss of skeletal muscle, has been reported to be associated with the prognosis of cancer and complications. The present study investigated the importance of sarcopenia with regard to the prognosis or postoperative complications of upper urothelial cancer patients who underwent nephro-ureterectomy. A total of sixty patients (male, n=44; female, n=16) underwent nephro-ureterectomy for upper urothelial carcinoma...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29434183/plasmacytoid-urothelial-carcinoma-of-ureter-with-retroperitoneal-metastasis-a-case-report
#5
Alexis Jibril, Andrew C Stevens
BACKGROUND Plasmacytoid is a rare histological variant of urothelial carcinoma (UC). Since the first reported case of plasmacytoid urothelial carcinoma (PUC), in 1991, only about 100 cases have since been reported, with most cases involving the bladder. Urothelial carcinomas of the upper urinary tract represent only 5% of urothelial cancers. To the best of our knowledge, there has only been 1 reported case of PUC of the ureter. PUC is a highly aggressive disease, with a poor prognosis. We present a rare biopsy-proven case of PUC of the ureter with retroperitoneal metastasis...
February 13, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29427584/discordance-between-ureteroscopic-biopsy-and-final-pathology-for-upper-tract-urothelial-carcinoma
#6
Ezra J Margolin, Justin T Matulay, Gen Li, Xiaosong Meng, Brian Chao, Varun Vijay, Hayley Silver, Timothy N Clinton, Laura-Maria Krabbe, Solomon L Woldu, Nirmish Singla, Aditya Bagrodia, Vitaly Margulis, William C Huang, Marc A Bjurlin, Ojas Shah, Christopher B Anderson
INTRODUCTION: We sought to evaluate the discordance between ureteroscopic biopsy and surgical pathology for grading and staging of upper tract urothelial carcinoma (UTUC) and to establish preoperative predictors of aggressive tumors. METHODS: We performed a retrospective review of 314 patients who underwent ureteroscopic biopsy followed by surgical management for UTUC from 2000-2016 at three institutions. Our primary outcomes were muscle-invasive (≥pT2) disease at surgical pathology and upgrading of clinical low-grade (cLG) tumors to pathologic high-grade (pHG)...
February 7, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29415874/confocal-laser-endomicroscopy-for-the-diagnosis-of-urothelial-carcinoma-in-the-bladder-and-the-upper-urinary-tract-protocols-for-two-prospective-explorative-studies
#7
Esmee Iml Liem, Jan Erik Freund, Joyce Baard, D Martijn de Bruin, M Pilar Laguna Pes, C Dilara Savci-Heijink, Ton G van Leeuwen, Theo M de Reijke, Jean Jmch de la Rosette
BACKGROUND: Visual confirmation of a suspicious lesion in the urinary tract is a major corner stone in diagnosing urothelial carcinoma. However, during cystoscopy (for bladder tumors) and ureterorenoscopy (for tumors of the upper urinary tract) no real-time histopathologic information can be obtained. Confocal laser endomicroscopy (CLE) is an optical imaging technique that allows for in vivo high-resolution imaging and may allow real-time tumor grading of urothelial lesions. OBJECTIVE: The primary objective of both studies is to develop descriptive criteria for in vivo CLE images of urothelial carcinoma (low-grade, high-grade, carcinoma in situ) and normal urothelium by comparing CLE images with corresponding histopathology...
February 7, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29396293/genomic-profile-of-urothelial-carcinoma-of-the-upper-tract-from-ureteroscopic-biopsy-feasibility-and-validation-using-matched-radical-nephroureterectomy-specimens
#8
Aditya Bagrodia, Francois Audenet, Eugene J Pietzak, Kwanghee Kim, Katie S Murray, Eugene K Cha, John P Sfakianos, Gopa Iyer, Nirmish Singla, Maria Arcila, Bernard H Bochner, Hikmat A Al-Ahmadie, David B Solit, Jonathan A Coleman
Urothelial carcinoma of the upper tract (UTUC) presents specific challenges regarding accurate staging and tumor sampling. We aimed to assess the feasibility of applying next-generation sequencing to biopsy specimens and gauged the concordance of their genetic profiles with matched radical nephroureterectomy (RNU) specimens. Of the 39 biopsy specimens collected, 36 (92%) had adequate material for sequencing using a hybridization-based exon capture assay (MSK-IMPACT). The most frequently altered genes across the patient cohort were consistent with the urothelial carcinoma-associated alterations identified in a cohort of 130 RNU specimens previously sequenced at our center, including mutations in the TERT promoter (64%), hotspot activating mutations in FGFR3 (64%), and frequent mutations in chromatin remodeling genes...
January 30, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29394848/-a-case-of-urothelial-carcinoma-who-underwent-pancreaticoduodenectomy-and-was-diagnosed-with-groove-pancreatitis-and-preoperatively-suffered-from-duodenal-stenosis
#9
Daisuke Takiuchi, Osakuni Morimoto, Ryohei Wada, Masaya Higashiguchi, Takashi Nonoshita, Kentaro Nishida, Noriko Wada, Kazuya Sakata, Yusuke Akamaru, Hirofumi Ota, Kunitaka Shibata, Hirotsugu Ohashi
We report a case of a highly advanced urothelial carcinoma accompanied by duodenal stenosis with pancreaticoduodenectomy. A6 6-year-old man presented with upper abdominal pain and vomiting. Acute pancreatitis and hydronephrosis were diagnosed with urgent hospitalization, but jaundice appeared, and stenosis of the duodenum was also found. Thus, we suspected groove pancreatitis or pancreatic cancer, and performed pancreaticoduodenectomy. However, poorly differentiated adenocarcinoma was observed in the retroperitoneal dissection surface in the intraoperative rapid tissue and right hemicolectomy, right nephrectomy, and right ureteral resection were added to the diagnosis...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29392926/diagnosis-and-kidney-sparing-treatments-for-upper-tract-urothelial-carcinoma-state-of-the-art
#10
Angelo Territo, Bear Foerster, Shahrokh F Shariat, Morgan Rouprêt, Jose M Gaya, Joan Palou, Alberto Breda
INTRODUCTION: Conservative management of upper tract urothelial cancer (UTUC) is becoming increasingly popular: the key to success is correct selection of patients with low-risk UTUC based on size (≤ 2 cm), focality (single lesion), stage (< T2), and grade (low grade). Despite the recent growing interest in the conservative approach to UTUC, the diagnostic process is still a challenge, and kidney-sparing surgery (KSS) is traditionally reserved for patients with contraindications to radical nephroureterectomy...
February 1, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29381018/prognostic-value-of-preoperative-systemic-inflammation-markers-in-localized-upper-tract-urothelial-cell-carcinoma-a-large-multicenter-cohort-analysis
#11
Sumin Son, Eu C Hwang, Seung I Jung, Dong D Kwon, Seock H Choi, Tae G Kwon, Joon H Noh, Myung K Kim, Ill Y Seo, Chul-Sung Kim, Sung G Kang, Jun Cheon, Hong K Ha, Chang W Jeong, Ja H Ku, Cheol Kwak
BACKGROUND: To investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow prognostic score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated...
January 29, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29379740/recurrent-papillary-renal-cell-carcinoma-with-concomitant-ipsilateral-upper-urinary-tract-urothelial-carcinoma-and-metachronous-urothelial-carcinoma-of-the-bladder
#12
Pooya Banapour, Kian Asanad, Roger Chan, Viet Q Tran
No abstract text is available yet for this article.
March 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29370814/concurrent-renal-cell-carcinoma-and-urothelial-carcinoma-long-term-follow-up-study-of-27-cases
#13
Nienie Qi, Yue Chen, Kan Gong, Hailong Li
BACKGROUND: To investigate the clinical manifestation, diagnosis, treatment, and outcome of simultaneous occurrence of renal cell carcinoma (RCC) and urothelial carcinoma. METHODS: Twenty-seven consecutive patients with synchronous renal cell carcinoma and urothelial carcinoma treated in two tertiary medical centers from March 2005 to December 2015 were retrospectively reviewed. Their clinical, pathological, and prognostic features were evaluated. Kaplan-Meier curves were used to estimate overall survival...
January 25, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29356359/impact-of-body-mass-index-on-the-oncological-outcomes-of-patients-with-upper-and-lower-urinary-tract-cancers-treated-with-radical-surgery-a-multi-institutional-retrospective-study
#14
Yasukiyo Murakami, Kazumasa Matsumoto, Masaomi Ikeda, Takuji Utsunomiya, Takahiro Hirayama, Dai Koguchi, Daisuke Matsuda, Norihiko Okuno, Yoshinori Taoka, Akira Irie, Masatsugu Iwamura
AIM: To evaluate the impact of body mass index (BMI) on the oncological outcomes of urothelial carcinoma (UC) patients. PATIENTS AND METHODS: We retrospectively analyzed data from 818 patients with upper tract urothelial cancer (UTUC) and bladder cancer (BC) who were treated with radical nephroureterectomy (RNU) or radical cystectomy (RC) between 1990 and 2015 at six different institutions in Japan. Patients with distant metastasis at diagnosis and those who received neoadjuvant therapies were excluded, leaving 727 eligible patients (UTUC: n = 441; BC: n = 286)...
January 22, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29348903/the-systemic-inflammation-based-glasgow-prognostic-score-as-a-powerful-prognostic-factor-in-patients-with-upper-tract-urothelial-carcinoma
#15
Teruo Inamoto, Hideyasu Matsuyama, Shigeru Sakano, Naokazu Ibuki, Kiyoshi Takahara, Kazumasa Komura, Tomoaki Takai, Takuya Tsujino, Yuki Yoshikawa, Koichiro Minami, Kazuhiro Nagao, Ryo Inoue, Haruhito Azuma
Introduction and Objective: The combination of C-reactive protein and albumin, the Glasgow Prognostic Score (GPS), had independent prognostic value in patients with varying cancers, except for upper tract urothelial carcinoma (UTUC). The aim of this study was to describe the relationship between GPS and survival in patients with UTUC after adjustment for other prognostic factors. Materials and Methods: We queried 2 UTUC databases. Retrospective clinical series on patients with localized UTUC managed by nephroureterectomy with bladder cuff, for whom data from the Yamaguchi Uro-Oncology Group and Osaka Medical College registry, including age, presence of bladder cancer, pT stage, lymphovascular invasion, C-reactive protein (CRP) and albumin, were analyzed...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29344681/timing-of-blood-transfusion-and-oncologic-outcomes-in-patients-treated-with-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#16
Aditya Bagrodia, Samuel Kaffenberger, Andrew Winer, Katie Murray, Michael Vacchio, Junting Zheng, Irina Ostrovnaya, Bernard H Bochner, Guido Dalbagni, Eugene K Cha, Jonathan A Coleman
PURPOSE: To evaluate the impact of timing of blood transfusion in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU). METHODS: Outcomes of consecutive patients with UTUC treated with RNU were analyzed. Clinicopathologic factors were compared using Fisher's exact test or the Wilcoxon rank-sum test between patients who received any transfusion and no transfusion, and between patients receiving intraoperative transfusion only and patients receiving no transfusion...
January 17, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29343917/editorial-comment-on-effects-of-tumor-size-and-location-on-survival-in-upper-tract-urothelial-carcinoma-after-nephroureterectomy
#17
EDITORIAL
Gagan Prakash, Gagan Gautam
No abstract text is available yet for this article.
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29343916/effects-of-tumor-size-and-location-on-survival-in-upper-tract-urothelial-carcinoma-after-nephroureterectomy
#18
Shreyas S Joshi, Laura L Quast, Sam S Chang, Sanjay G Patel
Introduction: Upper Tract Urothelial Carcinoma (UTUC) is a rare disease with few prognostic determinants. We sought to evaluate the impact of tumor size and location on patient survival following nephroureterectomy for UTUC. Materials and Methods: Data on 8284 patients treated with radical nephroureterectomy for UTUC in the United States between 1998 and 2011 were analyzed from the National Cancer Data Base. Univariable survivorship curves were generated based on pT stage, pN stage, grade, tumor size, and tumor site (renal pelvis vs...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29329444/prevention-of-ivr-a-need-for-investigation
#19
Idir Ouzaid, Evanguelos Xylinas
Intravesical recurrence (IVR) after RNU for UTUC is a frequent event, occurring in 20-50% of patients, mostly in the first postoperative year. Several retrospective studies have shown that predictors of IVR include clinical characteristics, surgical features and as well pathological characteristics (previous history of bladder cancer, pathological stage, lymph node involvement, cis, endoscopic distal ureter, etc.) management. Two prospective studies provide level I evidence for the safety and efficacy of intravesical single postoperative chemotherapy for patients treated with radical nephroureterectomy (RNU) for UTUC in order to prevent IVR...
January 10, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29323434/thulium-laser-ablation-facilitates-retrograde-intra-renal-surgery-for-upper-urinary-tract-urothelial-carcinoma
#20
Takashi Yoshida, Makoto Taguchi, Takaaki Inoue, Hidefumi Kinoshita, Tadashi Matsuda
No abstract text is available yet for this article.
January 11, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
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