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Upper tract urothelial carcinoma

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https://www.readbyqxmd.com/read/28644132/risk-of-acute-myocardial-infarction-in-upper-tract-urothelial-carcinoma-patients-receiving-radical-nephroureterectomy-a-population-based-cohort-study
#1
Shih-Yi Lin, Cheng-Li Lin, Chao-Hsiang Chang, His-Chin Wu, I-Kuan Wang, Che-Yi Chou, Ji-An Liang
BACKGROUND: The outcomes of upper tract urothelial carcinoma (UTUC) receiving radical nephroureterectomy were usually limited to small sample size, case-control studies, and often focused on cancer progression. Risk of acute myocardial infarction (AMI) in these patients was never investigated. RESULTS: The overall incidences of AMI were 3.39, 1.44, and 1.70 per 10,000 person-years in the radical nephroureterectomy, nonnephroureterectomy, and non-UTUC cohorts, respectively...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28638274/hypoxia-regulated-microrna-210-overexpression-is-associated-with-tumor-development-and-progression-in-upper-tract-urothelial-carcinoma
#2
Hung-Lung Ke, Wei-Ming Li, Hui-Hui Lin, Wei-Chi Hsu, Ya-Ling Hsu, Lin-Li Chang, Chun-Nung Huang, Ching-Chia Li, Hsin-Ping Chang, Hsin-Chih Yeh, Chien-Feng Li, Wen-Jeng Wu
BACKGROUND: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC). METHODS: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28636553/the-prognostic-and-diagnostic-value-of-circulating-tumor-cells-in-bladder-cancer-and-upper-tract-urothelial-carcinoma-a-meta-analysis-of-30-published-studies
#3
Zheng Zhang, Wei Fan, Qiaoling Deng, Shihui Tang, Ping Wang, Peipei Xu, June Wang, Mingxia Yu
There are inconsistent conclusions in the association between circulating tumor cells (CTCs) and urothelial cancer (UC). We performed a meta-analysis to assess the prognostic and diagnostic value of CTCs in UC. We search Medline, Embase and Web of science for relevant studies. The study was set up according to the inclusion/exclusion criteria. 30 published studies with a total of 2161 urothelial cancer patients were included. Meta-analysis showed that CTC-positive was significantly associated with tumor stage (≤ II vs III, IV) (OR = 4...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28634017/the-over-time-conditional-survival-of-intravesical-recurrence-in-upper-tract-urothelial-carcinoma
#4
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Takayuki Abe, Shuji Mikami, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
PURPOSE: Since a conditional survival (CS) analysis provides better estimates of survival times at each follow-up, we aimed to assess changes in conditional intravesical recurrence-free survival (IVRFS) rates after radical nephroureterectomy (RNU) and how the impact of well-known risk factors evolves over time, particularly in localized upper tract urothelial carcinoma (UTUC) patients. MATERIALS AND METHODS: We identified 364 patients with Ta-3N0M0 UTUC who underwent open or laparoscopic RNU at our three institutions...
June 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28632777/immunohistochemiocal-subtyping-using-ck20-and-ck5-can-identify-urothelial-carcinomas-of-the-upper-urinary-tract-with-a-poor-prognosis
#5
Danijel Sikic, Bastian Keck, Sven Wach, Helge Taubert, Bernd Wullich, Peter J Goebell, Andreas Kahlmeyer, Peter Olbert, Philipp Isfort, Wilhelm Nimphius, Arndt Hartmann, Johannes Giedl
PURPOSE: Genome-wide analyses revealed basal and luminal subtypes of urothelial carcinomas of the bladder. It is unknown if this subtyping can also be applied to upper tract urothelial carcinomas. MATERIALS AND METHODS: Tumor samples from 222 patients with upper tract urothelial carcinomas who were treated with radical nephroureterectomy were analyzed for the expression of seven basal/luminal immunohistochemical markers (CK5, EGFR, CD44, CK20, p63, GATA3, FOXA1)...
2017: PloS One
https://www.readbyqxmd.com/read/28625477/challenges-and-advances-in-the-diagnosis-biology-and-treatment-of-urothelial-upper-tract-and-bladder-carcinomas
#6
REVIEW
Jeanny B Aragon-Ching
Urothelial carcinomas span the bladder, ureter, and renal pelvis, and while there had been stagnation in the field of drug approval for the past two decades, there is now accelerated and regular US FDA approval of 5 immunotherapy agents. However, patients who inherently do not respond or progress on such therapies still represent an area of increased unmet need. In this special Seminars issue, we explore varying aspects of bladder urothelial carcinoma treatment with targeted therapies, the unique presentation and challenges in the treatment of upper tract and renal pelvis tumors, as well as new and emerging diagnostic imaging tools for varying genitourinary cancers...
July 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28611168/rapid-development-and-recurrence-of-translocation-renal-cell-carcinoma
#7
Ned Kinnear, Sam Wreghitt, Derek Barry Hennessey, Peter Liodakis
Translocation renal cell carcinoma (RCC) is a rare aggressive malignancy in adults. A 40-year-old man presented with painless macroscopic haematuria. Initial investigations of renal ultrasound, CT scan, urine culture and urine cytology were normal. On rigid cystoscopy and pyelo-ureteroscopy, bleeding was seen from a normal-appearing right renal upper pole. An arteriovenous malformation was suspected, and laser cautery was performed. Left renal biopsy was performed due to proteinuria and suggested IgA nephropathy...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28604991/ureteroscopy-in-the-diagnosis-of-upper-tract-transitional-cell-cancer-a-10-year-experience-providing-outcome-data-for-informed-consent
#8
Luke Hanna, Vera Chung, Ahmed Ali, Robert Ritchie, Ann Rogers, Mark Sullivan, Stephen Keoghane
PURPOSE: The aim of the study was to assess the effectiveness of ureteroscopy and biopsy in the diagnosis and management of upper tract urothelial carcinoma. METHODS: We retrospectively collated data from pathology, radiology and operating theatre data sets from two large UK hospitals. During the 10-year period examined, 160 patients underwent ureteroscopy prior to nephro-ureterectomy (NU)/distal ureterectomy (DU). RESULTS: Of the 160 patients identified, 140 were ureteroscopically evaluated and biopsied, 104 (74...
June 7, 2017: Urologia
https://www.readbyqxmd.com/read/28601352/comprehensive-genomic-characterization-of-upper-tract-urothelial-carcinoma
#9
Tyler J Moss, Yuan Qi, Liu Xi, Bo Peng, Tae-Beom Kim, Nader E Ezzedine, Maribel E Mosqueda, Charles C Guo, Bogdan A Czerniak, Michael Ittmann, David A Wheeler, Seth P Lerner, Surena F Matin
BACKGROUND: Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and genomic factors compared to bladder cancer. OBJECTIVE: To characterize the genomic landscape of UTUC and provide insights into its biology using comprehensive integrated genomic analyses. DESIGN, SETTING, AND PARTICIPANTS: We collected 31 untreated snap-frozen UTUC samples from two institutions and carried out whole-exome sequencing (WES) of DNA, RNA sequencing (RNAseq), and protein analysis...
June 7, 2017: European Urology
https://www.readbyqxmd.com/read/28600686/a-critical-prognostic-analysis-of-neutrophil-lymphocyte-ratio-for-patients-undergoing-nephroureterectomy-due-to-upper-urinary-tract-urothelial-carcinoma
#10
Mesut Altan, Hakan Bahadır Haberal, Bülent Akdoğan, Haluk Özen
BACKGROUND: To determine preoperative serum complete blood count parameters that affects survival of patients who underwent surgery for upper urinary tract urothelial cancer (UUT-UC). METHODS: Since 1990, 150 patients underwent nephroureterectomy with bladder cuff excision for UUT-UC at Hacettepe University. Patients with a history of muscle-invasive bladder cancer, adjuvant chemotherapy or metastasis at the time of diagnosis were excluded. One hundred and thirteen patients without infective symptoms and with a full set of serum data were evaluated retrospectively...
June 9, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28583528/human-polyomavirus-is-associated-with-earlier-onset-of-upper-urinary-tract-urothelial-carcinoma-in-patients-after-kidney-transplantation
#11
H L Luo, Y T Chen, S C Huang, T C Chen, P H Chiang, S S Lin, Y T Cheng
OBJECTIVES: Polyomavirus has been reported to be oncogenic due to viral integration into the human genome. A relatively high prevalence of upper urinary tract urothelial carcinoma (UTUC) was noted after kidney transplantation (KT) in Taiwan. However, little was known about the impact of polyomavirus on the urothelial cancer behavior. Therefore, the aim of this study is to analyze the characteristics of polyomavirus-related UTUC after KT. METHODS: From 2005 to 2014, 27 patients were found to have UTUCs after KT...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28583527/using-hematuria-as-detection-of-post-kidney-transplantation-upper-urinary-tract-urothelial-carcinoma-is-associated-with-delayed-diagnosis-of-cancer-occurrence
#12
S H Lin, H L Luo, Y T Chen, Y T Cheng
OBJECTIVES: Kidney transplantation (KT) is an important renal replacement therapy for end-stage renal disease (ESRD). The incidence of upper urinary tract urothelial carcinoma (UTUC) is relatively higher in Taiwan. According to our institutional database, early onset of post-KT UTUC is not uncommon. Early detection of post-KT UTUC is an important issue to improve oncologic outcome. Because painless hematuria is a common symptom for UTUC, this study analyzes whether using hematuria as post-KT UTUC screening delayed cancer diagnosis or not...
June 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28579283/optimizing-management-of-upper-tract-urothelial-carcinoma
#13
REVIEW
Matthew T Campbell, Amishi Y Shah, Surena F Matin, Arlene O Siefker-Radtke
Upper tract urothelial cancer (UTUC) is a rare cancer of the urothelium, comprising only a fraction of cases as compared to urothelial tumors of the bladder. As a result, systemic treatment approaches in bladder cancer are often applied to patients with UTUC. Given the anatomical location of these tumors, the age, the comorbid conditions of these patients with UTUC, and the need for radical nephroureterectomy for treatment, most patients have substantial impairment of renal reserve. There is growing evidence for the benefit of perioperative chemotherapy in this disease...
June 1, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28574835/prognostic-micrornas-in-upper-tract-urothelial-carcinoma-multicenter-and-international-validation-study
#14
Laura Izquierdo, Ruth Montalbo, Mercedes Ingelmo-Torres, Carme Mallofré, Miguel Ramírez-Backhaus, Jose Rubio, Antoine G Van der Heijden, Ewout Schaafsma, Antonio Lopez-Beltran, A Blanca, Nathan Lawrentschuk, Antonio Alcaraz, Lourdes Mengual
OBJECTIVE: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients. PATIENTS AND METHODS: Multicenter, international and retrospective study of formalin-fixed paraffin-embedded tissue samples from 103 UTUC patients (45 progressing and 58 non-progressing) who underwent radical nephroureterectomy. Total RNA was isolated and reverse transcribed. The expression of target miRNAs (miR-31-5p and miR-149-5p) and the endogenous control miR-218-5p was evaluated in all samples by reverse transcription quantitative PCR...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28556525/upper-urinary-tract-washings-outperform-voided-urine-specimens-to-detect-upper-tract-high-grade-urothelial-carcinoma
#15
M Lisa Zhang, Dorothy L Rosenthal, Christopher J VandenBussche
BACKGROUND: Cytological examination of voided urine (VU) can reliably diagnose high-grade urothelial carcinoma (HGUC) of the lower urinary tract, but its value in the diagnosis of upper tract HGUC (UTHGUC) is less well-established. To clarify the utility of VU in the setting of UTHGUC, we examined urinary specimens from patients with UTHGUC on follow-up surgical pathology. METHODS: 52 VU specimens (47 patients) with subsequent biopsy-proven UTHGUC were identified over a 12-year period; 32 had a corresponding upper tract urinary washing (UW) specimen...
May 28, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28554752/diagnostic-utility-of-ki-67-immunohistochemistry-in-small-endoscopic-biopsies-of-the-ureter-and-renal-pelvis
#16
Yuichi Koyama, Teppei Morikawa, Jimpei Miyakawa, Yu Miyama, Tohru Nakagawa, Yukio Homma, Masashi Fukayama
Diagnosis of upper urinary tract urothelial carcinoma in ureteroscopic biopsies is challenging. Therefore, an immunohistochemical marker that can differentiate between malignant and benign urothelium and predict final pathological features is necessary. In this study, we investigated Ki-67 expression in 26 ureteroscopic biopsies of the ureter and renal pelvis diagnosed with urothelial carcinoma (UC) and in 13 biopsies with non-neoplastic urothelium, using digital image analysis. The median Ki-67 labeling index was 1...
April 20, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28552573/evaluation-of-the-clinical-utility-of-renin-angiotensin-system-inhibitors-in-patients-undergoing-radical-surgery-for-urothelial-carcinoma-of-the-upper-urinary-tract
#17
Takashi Yoshida, Tomoaki Matsuzaki, Takashi Murota, Gen Kawa, Tadashi Matsuda, Hidefumi Kinoshita
BACKGROUND: Renin-angiotensin system (RAS) inhibitors are effective for treating patients with cancer. The present study evaluated the impact of RAS inhibitors, including angiotensin-2 converting enzyme inhibitors and angiotensin 2 receptor blockers, after patients underwent radical surgery for upper urinary tract urothelial carcinoma (UTUC). METHODS: This retrospective study included 312 patients with nonmetastatic UTUC who underwent radical surgery. The oncological outcomes of patients treated or not treated with RAS inhibitors following surgery were evaluated...
May 10, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28543959/epidemiology-of-urothelial-carcinoma
#18
REVIEW
Jun Miyazaki, Hiroyuki Nishiyama
The epithelium lining is defined as the mucosal surfaces of the renal collecting tubules, calyces and pelvis, as well as the ureter, bladder and urethra. The term "urothelium" is used to refer to these surfaces. Upper tract urothelial carcinoma is a rare subset of urothelial cancers with a poor prognosis. Urinary bladder cancer is the most common malignancy involving the urinary system. Upper tract urothelial carcinoma is more common in men than in women, with a male-to-female ratio of 2:1. The incidence of urinary bladder cancer is also higher in men...
May 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28538387/prognostic-significance-of-urothelial-carcinoma-with-divergent-differentiation-in-upper-urinary-tract-after-radical-nephroureterectomy-without-metastatic-diseases-a-retrospective-cohort-study
#19
Chuan Qin, En-Li Liang, Zhi-Yong Du, Xiao-Yu Qiu, Gang Tang, Fei-Ran Chen, Bo Zhang, Da-Wei Tian, Hai-Long Hu, Chang-Li Wu
To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537436/utilization-and-outcomes-of-nephroureterectomy-for-upper-tract-urothelial-carcinoma-by-surgical-approach
#20
Joseph Rodriguez, Vignesh T Packiam, William R Boysen, Scott C Johnson, Zacharly L Smith, Norm D Smith, Arieh Shalhav, Gary D Steinberg
OBJECTIVES: To compare outcomes and survival of open, robotic, and laparoscopic nephroureterectomy (ONU, RNU, LNU) using population-based data. METHODS: Using the National Cancer Database, we identified patients who underwent nephroureterectomy for localized UTUC between 2010 and 2013. Demographic and clinicopathologic characteristics were compared among the three operative approaches. Multivariate regression analyses were used to determine the impact of approach on performance of lymphadenectomy (LND), positive surgical margins (PSM), and overall survival (OS)...
May 24, 2017: Journal of Endourology
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