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Upper tract urothelial carcinoma

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https://www.readbyqxmd.com/read/28327458/nfatc1-expression-as-a-prognosticator-in-urothelial-carcinoma-of-the-upper-urinary-tract
#1
Takashi Kawahara, Satoshi Inoue, Kazutoshi Fujita, Taichi Mizushima, Hiroki Ide, Seiji Yamaguchi, Hiroaki Fushimi, Norio Nonomura, Hiroshi Miyamoto
We recently found that NFATc1, a member of the NFAT family and a key regulator of the immune response, could induce bladder carcinogenesis and cancer progression. In this study, we immunohistochemically stained for NFATc1 in upper urinary tract urothelial carcinoma (UUTUC) specimens and paired nonneoplastic urothelial tissues. NFATc1 was positive in 51 [52%; 40 (40%) weak (1+), 9 (9%) moderate (2+), and 2 (2%) strong (3+)] of 99 UUTUCs, which was significantly higher than in benign urothelium [30 (36%) of 83; 28 (34%) weak and 2 (2%) moderate] (0 vs 1+/2+/3+, P=...
March 16, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28322594/development-of-endoscopic-diagnosis-and-treatment-for-chronic-unilateral-hematuria-35-years-experience
#2
Ryuta Tanimoto, Hiromi Kumon, Demetrius H Bagley
PURPOSE: Chronic unilateral hematuria (CUH) is also called lateralizing essential hematuria, benign essential hematuria, and benign lateralizing hematuria, which was defined as intermittent or continuous gross hematuria that cannot be diagnosed with standard radiology and hematology studies, together with unilateral bloody efflux by cystoscopy. CUH is rare, but sometimes confused with malignancy or life threatening hemorrhage. Therefore, it can cause considerable anxiety to not only patients but also urologists...
March 21, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28317587/prolonged-pneumoperitoneum-time-is-an-independent-risk-factor-for-intravesical-recurrence-after-laparoscopic-radical-nephroureterectomy-in-upper-tract-urothelial-carcinoma
#3
Keisuke Shigeta, Eiji Kikuchi, Masayuki Hagiwara, Toshiyuki Ando, Ryuichi Mizuno, Akira Miyajima, Ken Nakagawa, Mototsugu Oya
OBJECTIVE: To evaluate the impact of pneumoperitoneum time on intravesical recurrence (IVR) in upper tract urothelial carcinoma (UTUC) patients who underwent laparoscopic radical nephroureterectomy (LRNU). PATIENTS AND METHODS: We identified 129 UTUC patients who underwent LRNU at our three institutions from 2004 to 2014. We evaluated the association of IVR rate and patient clinico-pathological characteristics including operation time. By retrospectively reviewing all videotapes, we defined pneumoperitoneum time as being from the infusion of pressurized CO2 gas with a pressure of 10-12 mmHg to extirpation of the kidney...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28275513/extending-indications-of-micropercutaneous-nephrolithotomy-it-is-not-just-about-cracking-stones
#4
Arvind P Ganpule, Jaspreet Singh Chhabra, S B Sudharsan, Ankush Jairath, Mohankumar Vijaykumar, Ravindra Sabnis, Mahesh R Desai
OBJECTIVE: To describe our experience and results of using the MicroPerc™ micropercutaneous nephrolithotomy armamentarium (PolyDiagnost, Germany) for unusual indications unexplored using this modality. PATIENTS AND METHODS: We used the MicroPerc™ system for stone clearance in three ureteric calculi, two bladder calculi, one case of urethral calculus, for antegrade biopsy in a case of upper tract urothelial carcinoma, for Deflux® (dextranomer/hyaluronic copolymer, Salix Pharmaceuticals, Uppsala, Sweden) injection in three cases of vesico-ureteric reflux (VUR), and three cases of posterior urethral valve (PUV) fulgurations...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28271274/split-bolus-ct-urogram-is-less-more
#5
Hiram Shaish, Jeffrey H Newhouse
PURPOSE: To determine the accuracy of split-bolus CT urogram (SB-CTU) without special maneuvers for ureteral distention in diagnosing upper urinary tract urothelial carcinoma (UCA). MATERIALS AND METHODS: A hospital database was searched from 1/1/10, to 9/1/15, for SB-CTU exams without special maneuvers for ureteral distention. Accuracy of SB-CTU for detecting upper and lower urinary tract UCA was computed by comparing the prospective radiology report with cystoscopy, ureteroscopy, and/or urologic clinical follow-up...
March 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28263136/lymphoepithelioma-like-carcinoma-of-the-ureter-a-rare-presentation-synchronous-with-conventional-urothelial-carcinoma
#6
Adam J Rensing, Anand Mohapatra, Aaron M Potretzke, Jennifer K Sehn, Robert S Figenshau
Lymphoepithelioma-like carcinoma (LELC) is a rare finding in the upper urinary tract. The presenting clinical findings mimic those of other more common upper-tract tumors, such as urothelial carcinoma. Preoperative imaging has not been shown to reliably predict the diagnosis of LELC. This tumor can be misdiagnosed as a reactive inflammatory lesion or lymphoma if the proper immunohistochemical stains for cytokeratin are not used.
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28263126/fluorescence-in-situ-hybridization-fish-in-the-diagnosis-of-bladder-and-upper-tract-urothelial-carcinoma-the-largest-single-institution-experience-to-date
#7
Leonard G Gomella, Mark J Mann, Ryan C Cleary, Scott G Hubosky, Demetrius H Bagley, Adeep B Thumar, Peter A McCue, Costas D Lallas, Edouard J Trabulsi
INTRODUCTION: We evaluated the UroVysion (Abbott Molecular, IL, USA) fluorescence in situ hybridization (FISH) assay for the diagnosis of urothelial cancer in patients diagnosed with or suspected to have bladder, upper tract urothelial carcinoma (UTUC), and combined upper and lower tract urothelial carcinoma (BC). MATERIALS AND METHODS: A single institution retrospective analysis comparing sensitivity, specificity, positive predictive value, and negative predictive values for FISH and urinary cytology...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28255413/can-lymphovascular-invasion-replace-the-prognostic-value-of-lymph-node-involvement-in-patients-with-upper-tract-urothelial-carcinoma-after-radical-nephroureterectomy
#8
Eun Sang Yoo, Yun-Sok Ha, Jun Nyung Lee, Bum Soo Kim, Bup Wan Kim, Seok-Soo Byun, Young Deuk Choi, Ho Won Kang, Seok-Joong Yun, Wun-Jae Kim, Jeong Hyun Kim, Tae Gyun Kwon
INTRODUCTION: This study aimed to evaluate whether lymphovascular invasion (LVI) can replace lymph node (LN) involvement as a prognostic marker in patients who do not undergo lymph node dissection (LND) during surgery in patients with upper tract urothelial carcinoma (UTUC). METHODS: A total of 505 patients who underwent radical nephroureterectomy (RNU) were recruited from four academic centres and divided into four groups: node negative (N0, Group 1); node positive (N+, Group 2); no LND without LVI (NxLVI-, Group 3); and no LND with LVI (NxLVI+, Group 4)...
July 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28251485/endoscopic-treatment-of-upper-tract-urothelial-carcinoma
#9
REVIEW
Daniel P Verges, Costas D Lallas, Scott G Hubosky, Demetrius H Bagley
PURPOSE OF REVIEW: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. RECENT FINDINGS: The PubMed database was queried using the following medical subject headings (MeSH terms): "carcinoma, transitional cell," "ureter," "ureteral neoplasms," "kidney pelvis," "endoscopy," "laser therapy," "ureteroscopy," "urologic surgical procedures," and "ureteroscopes...
April 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28247639/-renal-tumor-and-urolithiasis-is-there-a-relationship
#10
Yu G Alyaev, A M Pshikhachev, E V Shpot, G N Akopyan, A V Proskura
There is conflicting evidence on the impact of urolithiasis on the risk of developing cancer of kidney and upper urinary tract. Most researchers are of the opinion that there is a definite association between the diseases and clinicians should take the necessary measures to detect possible malignancy of the kidney and upper urinary tract in patients with urolithiasis at the earliest stages. However, the pathophysiological mechanisms that may underlie the development of renal cell carcinoma and urothelial cancer in patients with urolithiasis remain unexplored...
August 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28247066/trends-of-lymphadenectomy-in-upper-tract-urothelial-carcinoma-utuc-patients-treated-with-radical-nephroureterectomy
#11
Marco Moschini, Beat Foerster, Mohammad Abufaraj, Francesco Soria, Thomas Seisen, Morgan Roupret, Pierre Colin, Alexandre De la Taille, Benoit Peyronnet, Karim Bensalah, Roman Herout, Manfred Peter Wirth, Vladimir Novotny, Piotr Chlosta, Marco Bandini, Francesco Montorsi, Giuseppe Simone, Michele Gallucci, Giuseppe Romeo, Kazumasa Matsumoto, Pierre Karakiewicz, Alberto Briganti, Shahrokh F Shariat
INTRODUCTION: To evaluate temporal trends in the delivery and extent of lymphadenectomy (LND) in radical nephroureterectomy (RNU) performed in upper tract urothelial carcinoma (UTUC) patients. METHODS: We evaluated a multi institutional collaborative database composed by 1512 consecutive patients diagnosed with UTUC treated with RNU between 1990 and 2016. Year of surgery were grouped in five periods: 1990-1996, 1997-2002, 2003-2007, 2008-2012 and 2013-2016. Data about LND were available for all patients and numbers of nodes removed and positive were reported by dedicate uropathologists...
February 28, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28241123/upper-urinary-tract-tumors-which-diagnostic-methods-are-needed
#12
Matthias Maruschke, Wolfgang Kram, Annette Zimpfer, Günther Kundt, Oliver W Hakenberg
OBJECTIVES: We reviewed the data of patients with upper urinary tract (UUT) tumors to evaluate the effectiveness of diagnostic procedures. METHODS: This retrospective study evaluated tumor characteristics, imaging procedures, epidemiological and follow-up data of 113 patients. We analyzed the importance of non-invasive and endoscopic diagnosis in addition to imaging as well as the influence of stage and grade on recurrence rate. RESULTS: Most tumors were urothelial carcinomas (92...
February 28, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28216943/non-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-series-among-305-cases-at-a-tertiary-urology-institute
#13
Mohamed Mohamed Elawdy, Diaa-Eldin Taha, Yasser Osman, Mohamed Abd El-Hamid, Mohsen El-Mekresh
Non-transitional cell carcinomas (non-TCC) of the upper urinary tract as squamous cell carcinoma (SCC), adenocarcinoma, and small cell carcinoma (SmCC) are rare with few case reports in the literature. We retrospectively reviewed our patients who surgically treated for upper tract urothelial carcinoma from 1983 to 2013 for non-TCC pathological cancer characteristics and survival. Among 305 patients, only 5 (1.6%) cases were found: One case of SmCC, another had adenocarcinoma, and 3 SCC cases. None of them had intravesical recurrence and the cancer-specific survival for non-TCC cohort is markedly decreased (log-rank = 0...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28212539/fluorescence-in-situ-hybridization-status-of-voided-urine-predicts-invasive-and-high-grade-upper-tract-urothelial-carcinoma
#14
Xiaohong Su, Han Hao, Xuesong Li, Zhisong He, Kan Gong, Cuijian Zhang, Lin Cai, Qian Zhang, Lin Yao, Yi Ding, Yanqing Gong, Dong Fang, Zheng Zhang, Liqun Zhou
Here, we assessed the diagnostic accuracy of fluorescence in situ hybridization (FISH) for detecting aggressive upper tract urothelial carcinoma (UTUC). A total of 210 UTUC patients from a single hospital in China were enrolled in this retrospective study between 2012 and 2016. Patients were classified as FISH-positive or -negative based on FISH analysis of voided urine, and the clinicpathological characteristics of these two patient groups were compared. Patients with positive FISH results had more advanced tumor stages and higher tumor grades than those with negative results...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28197726/icud-guidelines-for-upper-tract-urothelial-carcinoma-a-state-of-the-art-evidence-based-guidance-for-clinical-decisions-regarding-diagnosis-management-and-treatment
#15
EDITORIAL
https://www.readbyqxmd.com/read/28188048/prognostic-value-of-leptin-receptor-overexpression-in-upper-tract-urothelial-carcinomas-in-taiwan
#16
Yi-Chen Lee, Wen-Jeng Wu, Hui-Hui Lin, Wei-Ming Li, Chun-Nung Huang, Wei-Chi Hsu, Lin-Li Chang, Ching-Chia Li, Hsin-Chih Yeh, Chien-Feng Li, Hung-Lung Ke
OBJECTIVES: Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: LEPR expression was examined in 110 tissue samples from patients with UTUC, using immunohistochemistry, and an analysis was performed to identify evidence of association between LEPR expression and different clinicopathologic variables...
January 11, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28174011/prognostic-role-of-neutrophil-to-lymphocyte-ratio-based-markers-during-pre-and-postadjuvant-chemotherapy-in-patients-with-advanced-urothelial-carcinoma-of-upper-urinary-tract
#17
Minyong Kang, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Ja Hyeon Ku
PURPOSE: The aim of the present study was to assess the prognostic significance of neutrophil-to-lymphocyte ratio (NLR)-based markers before and after adjuvant chemotherapy (ACH) in patients with urothelial carcinoma of the upper urinary tract (UTUC) undergoing radical nephroureterectomy (RNU) and ACH. MATERIALS AND METHODS: The data from 112 patients with advanced UTUC who had undergone first-line ACH after RNU from 1994 to 2012 were reviewed. After excluding 22 patients, the clinicopathologic data for 90 patients were analyzed, in particular, the NLR and derived NLR (dNLR) preoperatively and before and after ACH...
January 12, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28169993/the-evolving-genomic-landscape-of-urothelial-carcinoma
#18
REVIEW
Alexander P Glaser, Damiano Fantini, Ali Shilatifard, Edward M Schaeffer, Joshua J Meeks
Survival of patients with urothelial carcinoma (including bladder cancer and upper tract urothelial carcinoma) is limited by our current approaches to staging, surgery, and chemotherapy. Large-scale, next-generation sequencing collaborations, such as The Cancer Genome Atlas, have already identified drivers and vulnerabilities of urothelial carcinoma. This disease has a high degree of mutational heterogeneity and a high frequency of somatic mutations compared with other solid tumours, potentially resulting in an increased neoantigen burden...
February 7, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28152158/association-between-lymph-node-yield-and-survival-among-patients-undergoing-radical-nephroureterectomy-for-urothelial-carcinoma-of-the-upper-tract
#19
Piotr Zareba, Barak Rosenzweig, Andrew G Winer, Jonathan A Coleman
BACKGROUND: Prior studies examining the value of lymph node (LN) dissection (LND) in patients with urothelial carcinoma of the upper urinary tract (UTUC) have produced conflicting results. The objective of the current study was to assess the relationship between LN yield and survival among patients undergoing radical nephroureterectomy (RNU). METHODS: The National Cancer Data Base was used to identify patients with non-metastatic UTUC who were treated with RNU between 2004 and 2012...
February 2, 2017: Cancer
https://www.readbyqxmd.com/read/28144859/pulmonary-metastasis-from-urothelial-carcinoma-of-the-upper-urinary-tract-29%C3%A2-years-after-nephrectomy
#20
Koji Kawaguchi, Toshiki Okasaka, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shuhei Hakiri, Naoki Ozeki, Kohei Yokoi
BACKGROUND: Late pulmonary metastasis from urothelial carcinoma (UC) of the upper urinary tract is extremely rare. CASE PRESENTATION: A 76-year-old man was referred to our hospital due to an abnormal shadow on chest X-ray. He had a history of left nephrectomy with a diagnosis of UC in the renal pelvis 29 years previously. Computed tomography showed a mass lesion in the right middle lobe of the lung that measured 4.9 cm in diameter. A transbronchial biopsy revealed the tumor to be metastatic pulmonary UC, and he underwent right middle lobectomy of the lung...
December 2017: Surgical Case Reports
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