keyword
MENU ▼
Read by QxMD icon Read
search

Upper tract urothelial carcinoma

keyword
https://www.readbyqxmd.com/read/29046434/aristolochic-acids-and-their-derivatives-are-widely-implicated-in-liver-cancers-in-taiwan-and-throughout-asia
#1
Alvin W T Ng, Song Ling Poon, Mi Ni Huang, Jing Quan Lim, Arnoud Boot, Willie Yu, Yuka Suzuki, Saranya Thangaraju, Cedric C Y Ng, Patrick Tan, See-Tong Pang, Hao-Yi Huang, Ming-Chin Yu, Po-Huang Lee, Sen-Yung Hsieh, Alex Y Chang, Bin T Teh, Steven G Rozen
Many traditional pharmacopeias include Aristolochia and related plants, which contain nephrotoxins and mutagens in the form of aristolochic acids and similar compounds (collectively, AA). AA is implicated in multiple cancer types, sometimes with very high mutational burdens, especially in upper tract urothelial cancers (UTUCs). AA-associated kidney failure and UTUCs are prevalent in Taiwan, but AA's role in hepatocellular carcinomas (HCCs) there remains unexplored. Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78% showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes...
October 18, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/29039894/ureteral-orifice-involvement-by-urothelial-carcinoma-long-term-oncologic-and-functional-outcomes
#2
Muammer Altok, Ali F Sahin, Mehmet I Gokce, Gokhan R Ekin, Rauf Taner Divrik
PURPOSE: Bladder cancer (BC) may involve the ureteral orifice, and the resection of the orifice has oncological and functional consequences such as development of upper tract urothelial carcinoma (UTUC), vesicoureteral reflux or ureteral stenosis. The aim of this study was to investigate the oncological and functional outcomes of the ureteral orifice resection in BC patients and determine the predictive factors for UTUC development. MATERIALS AND METHODS: A total of 1359 patients diagnosed with BC, between 1992 and 2012, were reviewed retrospectively...
October 17, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29037861/biologic-behavior-and-long-term-outcomes-of-carcinoma-in-situ-in-upper-urinary-tract-managed-by-radical-nephroureterectomy
#3
Teruo Inamoto, Hideyasu Matsuyama, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Kiyohide Fujimoto, Hiroaki Shiina, Shigeru Sakano, Kazuhiro Nagao, Makito Miyake, Yoshihiro Tatsumi, Hiroaki Yasumoto, Haruhito Azuma
BACKGROUND AND OBJECTIVES: Carcinoma in situ (CIS) in urothelial carcinoma generally has poor prognosis, but the outcomes of pure/primary CIS tumor (p-CIS) and the behavior of concomitant CIS (c-CIS) with pTa-pT4 upper tract urothelial carcinoma (UTUC) managed by nephroureterectomy has not been specified. The aim of our study was to explore the biological and prognostic features of c-CIS, compared with p-CIS. PATIENTS AND METHODS: We queried multicenter UTUC database...
October 13, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29032580/impact-of-ureteroscopy-before-radical-nephroureterectomy-for-upper-tract-urothelial-carcinomas-on-oncologic-outcomes-a-meta-analysis
#4
Run-Qi Guo, Peng Hong, Geng-Yan Xiong, Zhang Lei, Dong Fang, Xue-Song Li, Kai Zhang, Li-Qun Zhou
OBJECTIVES: To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUC) has an impact on oncologic outcomes. MATERIALS AND METHODS: We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described URS performed on patients with UTUC and conducted a standard meta-analysis on survival outcomes. RESULTS: Our meta-analysis included eight eligible studies containing 3,975 patients...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032451/impact-of-body-mass-index-on-the-oncological-outcomes-of-patients-treated-with-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#5
Yohann Dabi, Mohammed El Mrini, Igor Duquesnes, Nicolas Barry Delongchamps, Mathilde Sibony, Marc Zerbib, Evanguelos Xylinas
PURPOSE: To evaluate the association between body mass index (BMI) and oncological outcomes in patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). METHODS: We retrospectively reviewed 237 consecutive patients treated with RNU for UTUC at our institution between 1990 and 2012. Univariable and multivariable cox regression models investigated the association of BMI with disease recurrence, cancer-specific mortality, and overall mortality...
October 14, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29031419/impact-of-surgical-waiting-time-on-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-national-cancer-database-study
#6
Leilei Xia, Benjamin L Taylor, Jose E Pulido, Thomas J Guzzo
PURPOSE: To evaluate the impact of surgical waiting time (SWT) on the survival outcome in patients with upper tract urothelial carcinoma (UTUC). MATERIALS AND METHODS: We identified patients with nonmetastatic UTUC who underwent radical nephroureterectomy (RNU) between 2004 and 2013 in the National Cancer Database. The association between SWT and overall survival (OS) was evaluated using Cox proportional hazards regression. SWT was categorized into 6 groups: SWT ≤ 7 days, SWT 8 to 30 days, SWT 31 to 60 days, SWT 61 to 90 days, SWT 91 to 120 days, and SWT 121 to 180 days...
October 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29029534/is-preoperative-chronic-kidney-disease-status-associated-with-oncologic-outcomes-in-upper-urinary-tract-urothelial-carcinoma-a-multicenter-propensity-score-matched-analysis
#7
Ho Song Yu, Jun Eul Hwang, Ho Seok Chung, Yang Hyun Cho, Myung Soo Kim, Eu Chang Hwang, Kyung Jin Oh, Sun-Ouck Kim, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Kwangsung Park, Soo Bang Ryu, Sung-Hoon Jung, Young Hoe Hur, Joon Hwa Noh, Myung Ki Kim, Ill Young Seo, Chul-Sung Kim, Sung Gu Kang, Seok Ho Kang, Jun Cheon
PURPOSE: The aim of this study was to determine the effect of preoperative chronic kidney disease (CKD) on the prognosis of patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). RESULTS: The median follow-up period was 31.1 months (interquartile range: 16.2-55.7 months). Among the study patients, 224 patients in the non-CKD group were selected via propensity score matching. The median recurrence-free, cancer-specific, and overall survival were significantly shorter for patients with preoperative CKD than for non-CKD patients (p = 0...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28978171/prognostic-scores-based-on-the-preoperative-plasma-fibrinogen-and-serum-albumin-level-as-a-prognostic-factor-in-patients-with-upper-urinary-tract-urothelial-carcinoma
#8
Jianfeng Cui, Meng Yu, Ning Zhang, Shiyu Wang, Yaofeng Zhu, Shouzhen Chen, Kejia Zhu, Jian Du, Hongda Zhao, Xigao Liu, Pengxiang Chen, Wenbo Wang, Dongqing Zhang, Benkang Shi
This study is to clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC). We retrospectively evaluated clinicopathological data on 169 patients who underwent surgery between 2006 and 2013. The FA score was calculated based on cutoff values of 3.53g/L for fibrinogen and 43.56 g/L for albumin. Overall survival and cancer specific survival was assessed using the Kaplan-Meier method and the equivalences of the curves were tested by log-rank tests...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28977980/prognostic-value-of-neutrophil-to-lymphocyte-ratio-in-urothelial-carcinoma-of-the-upper-urinary-tract-and-bladder-a-systematic-review-and-meta-analysis
#9
Xintao Li, Xin Ma, Lu Tang, Baojun Wang, Luyao Chen, Fan Zhang, Xu Zhang
The neutrophil-to-lymphocyte ratio (NLR) is an inflammation marker that has prognostic value for various tumors, but its prognostic value in urothelial carcinoma (UC) remains controversial. This meta-analysis investigated the prognostic value of NLR in UC. A systematic search was performed on PubMed, ISI Web of Science, and Embase for studies focusing on the association between NLR and clinical features or prognosis of UC and published until November 2016. Prognostic outcomes and clinical features were collected and analyzed...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28972702/survival-outcomes-for-patients-with-localized-upper-tract-urothelial-carcinoma-managed-with-non-definitive-treatment
#10
Jamil S Syed, Kevin A Nguyen, Alfredo Suarez-Sarmiento, Katelyn Johnson, Michael S Leapman, Jay D Raman, Brian Shuch
OBJECTIVE: To investigate the outcomes of patients with upper tract urothelial carcinoma (UTUC) with non-definitive therapy, which currently remains unknown. SUBJECTS/PATIENTS AND METHODS: We utilized the Surveillance, Epidemiology, and End Results (SEER) database to identify individuals with a localized, histologically confirmed kidney/renal pelvis and ureteral urothelial carcinoma. Survival analysis using the Kaplan Meier method was performed. A competing risk model evaluated the cumulative incidence and predictors of cancer specific mortality (CSM)...
October 3, 2017: BJU International
https://www.readbyqxmd.com/read/28967037/loss-of-stromal-antigen-2-stag2-expression-in-upper-urinary-tract-carcinoma-differential-prognostic-effect-according-to-the-ki-67-proliferating-index
#11
Jimpei Miyakawa, Teppei Morikawa, Yu Miyama, Tohru Nakagawa, Taketo Kawai, Yukio Homma, Masashi Fukayama
BACKGROUND: Inactivating mutation and consequent expression loss of stromal antigen 2 (STAG2, also known as SA2), a component of the cohesion complex, is one of the most common genetic aberrations in urothelial carcinoma. However, the clinicopathologic or prognostic significance of STAG2 alterations in upper tract urothelial carcinoma (UTUC) is largely unknown. METHODS: This study immunohistochemically examined the expression of STAG2 in 171 patients with UTUC. The correlations of STAG2 loss with clinicopathologic features and patients' prognoses were examined...
October 2, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28940789/personalized-peptide-vaccination-as-second-line-treatment-for-metastatic-upper-tract-urothelial-carcinoma
#12
Shigetaka Suekane, Kousuke Ueda, Kiyoaki Nishihara, Tetsuro Sasada, Takuto Yamashita, Noriko Koga, Shigeru Yutani, Shigeki Shichijo, Kyogo Itoh, Tsukasa Igawa, Masanori Noguchi
This study investigated the applicability of personalized peptide vaccination (PPV) for patients with metastatic upper tract urothelial cancer (mUTUC) after failure of platinum-based chemotherapy. In this single arm, open-label, phase II clinical trial, patients with mUTUC received PPV at a single institution. Personalized peptide vaccination treatment used a maximum of four peptides chosen from 27 candidate peptides according to human leukocyte antigen types and peptide-reactive IgG titers, for six s.c. injections weekly as one cycle...
September 22, 2017: Cancer Science
https://www.readbyqxmd.com/read/28940605/adjuvant-chemotherapy-after-radical-nephroureterectomy-does-not-improve-survival-in-patients-with-upper-tract-urothelial-carcinoma-a-joint-study-by-the-european-association-of-urology-young-academic-urologists-and-the%C3%A2-upper-tract-urothelial-carcinoma-collaboration
#13
Andrea Necchi, Salvatore Lo Vullo, Luigi Mariani, Marco Moschini, Kees Hendricksen, Michael Rink, Roman Sosnowski, Jakub Dobruch, Jay D Raman, Christopher G Wood, Vitaly Margulis, Morgan Roupret, Alberto Briganti, Francesco Montorsi, Evanguelos Xylinas, Shahrokh F Shariat
OBJECTIVE: To analyse the outcomes of adjuvant chemotherapy vs observation in a multicentre cohort of patients with upper tract urothelial carcinoma (UTUC) in order to clarify whether such patients benefit from adjuvant chemotherapy after radical nephroureterectomy (RNU). PATIENTS AND METHODS: Data from 15 centres were collected for a total of 1544 patients, treated between 2000 and 2015. Criteria for patient selection included pT2-4N0/x stage, or lymph node-positive disease, and prior RNU...
September 20, 2017: BJU International
https://www.readbyqxmd.com/read/28938656/the-prognostic-and-diagnostic-value-of-circulating-tumor-cells-in-bladder-cancer-and-upper-tract-urothelial-carcinoma-a-meta-analysis-of-30-published-studies
#14
Zheng Zhang, Wei Fan, Qiaoling Deng, Shihui Tang, Ping Wang, Peipei Xu, June Wang, Mingxia Yu
There are inconsistent conclusions in the association between circulating tumor cells (CTCs) and urothelial cancer (UC). We performed a meta-analysis to assess the prognostic and diagnostic value of CTCs in UC. We search Medline, Embase and Web of science for relevant studies. The study was set up according to the inclusion/exclusion criteria. 30 published studies with a total of 2161 urothelial cancer patients were included. Meta-analysis showed that CTC-positive was significantly associated with tumor stage (≤ II vs III, IV) (OR = 4...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937484/diagnostic-accuracy-of-qualitative-and-quantitative-computed-tomography-analysis-for-diagnosis-of-pathological-grade-and-stage-in-upper-tract-urothelial-cell-carcinoma
#15
Suraj Mammen, Satheesh Krishna, Matthew Quon, Wael M Shabana, Shaheed W Hakim, Trevor A Flood, Nicola Schieda
OBJECTIVE: The aim of this study was to compare grade and stage of upper tract urothelial cell carcinoma (UCC) using computed tomography. MATERIALS AND METHODS: With institutional review board approval, 48 patients with 49 UCC (44 high grade and 5 low grade, 26 ≤ T1 and 23 ≥ T2) underwent nephroureterectomy and preoperative computed tomography between 2013 and 2015. Two blinded radiologists assessed for tumor appearance (filling defect/mass or wall thickening/stricture), margin (smooth or spiculated/irregular), texture (homogeneous, heterogeneous), hydronephrosis, and calcification...
September 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28929209/upper-urinary-tract-effects-after-irreversible-electroporation-ire-of-human-localised-renal-cell-carcinoma-rcc-in-the-irene-pilot-phase-2a-ablate-and-resect-study
#16
J J Wendler, M Pech, J Köllermann, B Friebe, S Siedentopf, S Blaschke, D Schindele, M Porsch, D Baumunk, J Jürgens, F Fischbach, J Ricke, M Schostak, M Böhm, U B Liehr
PURPOSE: Irreversible electroporation (IRE) is a new potential ablation modality for small renal masses. Animal experiments have shown preservation of the urine-collecting system (UCS). The purpose of this clinical study was to perform the first evaluation and comparison of IRE's effects on the renal UCS by using urinary cytology, magnetic-resonance imaging, and resection histology in men after IRE of pT1a renal-cell carcinoma (RCC). METHODS: Seven patients with biopsy-proven RCC pT1a cN0cM0 underwent IRE in a phase 2a pilot ablate-and-resect study (IRENE trial)...
September 19, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28905781/re-effectiveness-of-adjuvant-chemotherapy-after-radical-nephroureterectomy-for-locally-advanced-and-or-positive-regional-lymph%C3%A2-node-upper-tract-urothelial-carcinoma
#17
https://www.readbyqxmd.com/read/28903527/efficacy-of-early-ureteral-ligation-on-prevention-of-intravesical-recurrence-after-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-carcinoma-a-prospective-single-arm-multicenter-clinical-trial
#18
Shinichi Yamashita, Akihiro Ito, Koji Mitsuzuka, Naomasa Ioritani, Shigeto Ishidoya, Yoshihiro Ikeda, Kenji Numahata, Kazuhiko Orikasa, Tatsuo Tochigi, Fumihiko Soma, Takashige Namima, Yoichi Arai
Objective: The rate of intravesical recurrence after radical nephroureterectomy for upper urinary tract urothelial carcinoma is high. Seeding upper urinary tract urothelial carcinoma cells onto the damaged bladder wall is considered to be one of the causes of intravesical recurrence after radical nephroureterectomy. We evaluated the utility of early ureteral ligation in preventing the intravesical recurrence. Methods: This prospective single-arm clinical trial included patients who underwent radical nephroureterectomy for upper urinary tract urothelial carcinoma in the Tohoku Urological Evidence-Based Medicine Study Group between 2012 and 2013...
September 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28901308/utility-of-fluorescence-in-situ-hybridization-analysis-for-detecting-upper-urinary-tract-urothelial-carcinoma
#19
Jiang Yu, Hui Xiong, Chunxiao Wei, Zilian Cui, Xunbo Jin, Jianjun Zhang
OBJECTIVES: The objective of this study was to evaluate the clinical utility of fluorescence in situ hybridization (FISH) in the detection of upper urinary tract-urothelial carcinoma (UUT-UC). METHODS: Between November 2011 and November 2015, voided urine specimens from 52 consecutive patients with UUT-UC and 26 controls were collected for both FISH test and cytology. Sensitivity and specificity of FISH test and cytology were determined and compared. The frequency of chromosomal aberrations was also analyzed...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28889922/the-effect-of-ab0-and-rhesus-blood-grouping-systems-on-oncological-outcome-in-patients-undergoing-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma
#20
Michael Rink, Oliver Engel, Georgios Gakis, Hans Martin Fritsche, Malte W Vetterlein, Armin Soave, Sven Peine, Atiqullah Aziz, Roland Dahlem, Arnulf Stenzl, Maximilian Burger, Shahrokh F Shariat, Margit Fisch, Philipp Gild
OBJECTIVES: To investigate the effect of AB0 and Rhesus factor expression blood group systems on outcomes of upper tract urothelial carcinoma patients treated with radical nephroureterectomy. PATIENTS AND METHODS: We analyzed data from 271 patients with upper tract urothelial carcinoma who underwent radical nephroureterectomy at 3 German academic institutions. Cox and logistic regression models assessed the association of AB0 blood group antigen and Rhesus factor expression with tumor biologic features and outcomes, respectively...
September 7, 2017: Urologic Oncology
keyword
keyword
51392
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"