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https://www.readbyqxmd.com/read/28103447/pharmacotherapy-for-treating-metastatic-clear-cell-renal-cell-carcinoma
#1
Camillo Porta, Silvia Chiellino, Alessandra Ferrari, Sara Mariucci, Wanda Liguigli
Over the past decade metastatic renal cell carcinoma (RCC) treatment landscape has dramatically evolved from the era of cytokines-based immunotherapy (which benefited very few patients, at the expenses of high toxicities) to the present era of targeted agents and novel immunotherapeutics, greatly improving the prognosis of our patients. Areas covered: Here we have reviewed the present status of the medical treatment of metastatic RCC. To do this, we interrogated the Medline database, as well as the proceedings of the main Oncological and Urological conferences for the relevant trials coducted so far...
January 19, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28094199/risk-of-prostate-cancer-diagnosis-and-mortality-in-men-with-a-benign-initial-transrectal-ultrasound-guided-biopsy-set-a-population-based-study
#2
Nina Klemann, M Andreas Røder, J Thomas Helgstrand, Klaus Brasso, Birgitte G Toft, Ben Vainer, Peter Iversen
BACKGROUND: The risk of missing prostate cancer in the transrectal ultrasound-guided systematic biopsies of the prostate in men with suspected prostate cancer is a key problem in urological oncology. Repeat biopsy or MRI-guided biopsies have been suggested to increase sensitivity for diagnosis of prostate cancer, but the risk of disease-specific mortality in men who present with raised prostate-specific antigen (PSA) concentration and a benign initial biopsy result remains unknown. We investigated the risk of overall and prostate cancer-specific mortality in men with a benign initial biopsy set...
January 13, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28089304/management-of-prostate-cancer-in-elderly-patients-recommendations-of-a-task-force-of-the-international-society-of-geriatric-oncology
#3
REVIEW
Jean-Pierre Droz, Gilles Albrand, Silke Gillessen, Simon Hughes, Nicolas Mottet, Stéphane Oudard, Heather Payne, Martine Puts, Gilbert Zulian, Lodovico Balducci, Matti Aapro
CONTEXT: Prostate cancer is the most frequent male cancer. Since the median age of diagnosis is 66 yr, many patients require both geriatric and urologic evaluation if treatment is to be tailored to individual circumstances including comorbidities and frailty. OBJECTIVE: To update the 2014 International Society of Geriatric Oncology (SIOG) guidelines on prostate cancer in men aged >70 yr. The update includes new material on health status evaluation and the treatment of localised, advanced, and castrate-resistant disease...
January 11, 2017: European Urology
https://www.readbyqxmd.com/read/28062895/3d-printed-renal-cancer-models-derived-from-mri-data-application-in-pre-surgical-planning
#4
Nicole Wake, Temitope Rude, Stella K Kang, Michael D Stifelman, James F Borin, Daniel K Sodickson, William C Huang, Hersh Chandarana
OBJECTIVE: To determine whether patient-specific 3D printed renal tumor models change pre-operative planning decisions made by urological surgeons in preparation for complex renal mass surgical procedures. MATERIALS AND METHODS: From our ongoing IRB approved study on renal neoplasms, ten renal mass cases were retrospectively selected based on Nephrometry Score greater than 5 (range 6-10). A 3D post-contrast fat-suppressed gradient-echo T1-weighted sequence was used to generate 3D printed models...
January 7, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28058776/guideline-of-guidelines-non-muscle-invasive-bladder-cancer
#5
REVIEW
Solomon L Woldu, Aditya Bagrodia, Yair Lotan
Non-muscle invasive bladder cancer (NMIBC) represents the vast majority of bladder cancer diagnoses, however this definition represents a spectrum of disease with a variable clinical course notable for significant risk of recurrence and potential for progression. Management involves risk-adapted strategies of cystoscopic surveillance and intravesical therapy with a goal of bladder preservation when safe to do so. Multiple organizational guidelines exist to help practitioners manage this complicated disease process, however adherence to management principles amongt practicing urologists is reportedly low...
January 6, 2017: BJU International
https://www.readbyqxmd.com/read/28058002/the-diagnostic-yield-of-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-recurrent-testicular-seminoma
#6
Athanasios Bantis, Petros Sountoulides, Linda Metaxa, Pavlos Pavlidis, Eleni Aggelonidou, Halil Arif, Athanasios Zisimopoulos
The use of positron emission tomography-computed tomography (PET-CT) scan imaging is undoubtedly a significant evolution in oncological urology, although at present of limited use in every day urology practice. The aim of this study is to highlight the indication and diagnostic accuracy of fluorine-18 fluorodeoxyglucose PET/CT in the staging of a patient with metachronous bilateral testicular seminoma, elevated tumor markers, and equivocal conventional imaging findings.
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28029399/global-burden-of-urologic-cancers-1990-2013
#7
REVIEW
Geolani W Dy, John L Gore, Mohammad H Forouzanfar, Mohsen Naghavi, Christina Fitzmaurice
CONTEXT: Kidney, prostate, and bladder cancers increase with age and are influenced partly by modifiable risk factors. Urological cancer rates may increase substantially amid a growing, aging population. OBJECTIVE: To describe kidney, bladder, and prostate cancer incidence, mortality, and risk factor-attributable bladder and kidney cancer deaths between 1990 and 2013, by age, sex, and development status. EVIDENCE ACQUISITION: Cancer mortality data were derived from global vital registries...
October 28, 2016: European Urology
https://www.readbyqxmd.com/read/28024653/comparison-of-2015-medicare-relative-value-units-for-gender-specific-procedures-gynecologic-and-gynecologic-oncologic-versus-urologic-cpt-coding-has-time-healed-gender-worth
#8
M F Benoit, J F Ma, B A Upperman
BACKGROUND: In 1992, Congress implemented a relative value unit (RVU) payment system to set reimbursement for all procedures covered by Medicare. In 1997, data supported that a significant gender bias existed in reimbursement for gynecologic compared to urologic procedures. The present study was performed to compare work and total RVU's for gender specific procedures effective January 2015 and to evaluate if time has healed the gender-based RVU worth. METHODS: Using the 2015 CPT codes, we compared work and total RVU's for 50 pairs of gender specific procedures...
December 23, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/28009144/robot-assisted-lymphadenectomy-in-urology-pelvic-retroperitoneal-and-inguinal
#9
Giovannalberto Pini, Surena F Matin, Nazareno Suardi, Mihir Desai, Inderbir Gill, James Porter, Robert J Stein, Rene Sotelo, Franco Gaboardi, Francesco Porpiglia
Lymph node dissection represents an essential surgical step in the treatment of the most commonly treated urological cancers. The introduction of robotic surgery has lead to the possibility of treating these diseases with a minimally invasive surgical approach, but the surgical principles of open surgery need to be carefully respected in order to achieve comparable oncological results. Therefore, the robotic approach to urological cancers must include a carefully performed lymph node dissection when indicated...
February 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/28005154/-pathogenesis-of-urological-complications-after-radiation-therapy
#10
Y Tolkach, G Kristiansen
Radiation therapy is a treatment modality that is often used in the uro-oncological setting. The common indication for the radiation therapy in the urological sphere is prostate cancer, whether it is used primarily as a radical approach, or postoperatively as adjuvant or salvage therapy. All urological organs are sensitive to radiation injury with the urinary bladder being the most susceptible with a typical cascade including acute and late changes, arising in the dose-dependent manner. The common indication for radiation therapy in urology is prostate cancer, which collaterally affects the urinary bladder and rarely urethra (especially the bulbo-membranous urethra)...
December 22, 2016: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27998677/clinically-localized-prostate-cancer-in-2017-a-review-of-comparative-effectiveness
#11
REVIEW
Hugh J Lavery, Matthew R Cooperberg
Introducing the topic of comparative effectiveness for prostate cancer treatments with a reminder of the disease's heterogeneity risks tautology. However, the profound variation both in this cancer's biology and its clinical course is increasingly widely recognized, while management alternatives for clinically localized prostate cancer have exploded. Available options now include active surveillance, multiple surgical approaches to prostatectomy, various forms of external-beam and interstitial radiation, and a growing list of energy ablative technologies...
December 17, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27987030/improved-decision-making-in-intermediate-risk-prostate-cancer-a-multicenter-study-on-pathologic-and-oncologic-outcomes-after-radical-prostatectomy
#12
Jean Baptiste Beauval, Guillaume Ploussard, Bastien Cabarrou, Mathieu Roumiguié, Adil Ouzzane, Jérome Gas, Annabelle Goujon, Gautier Marcq, Romain Mathieu, Sébastien Vincendeau, Xavier Cathelineau, Pierre Mongiat-Artus, Laurent Salomon, Michel Soulié, Arnaud Méjean, Alexandre de La Taille, Morgan Rouprêt, François Rozet
BACKGROUND: Prognoses for intermediate-risk prostate cancer (PCa) remain heterogeneous. Improved substratification could optimize treatment and monitoring strategies. The objective was to validate this subclassification in a radical prostatectomy (RP) series. METHODS: Between 2000 and 2011, 4038 patients who underwent RP for intermediate-risk PCa in seven French academic centers were included. Unfavorable intermediate-risk (UIR) PCa was defined as having a primary Gleason score of 4, ≥50% positive biopsy cores (PPBC), or more than one D'Amico intermediate-risk factor (i...
December 16, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27986529/patterns-of-performance-of-surgical-oncology-by-north-american-pediatric-urologists-a-report-from-the-pediatric-urologic-oncology-working-group-puowg-of-the-society-for-pediatric-urology-spu
#13
Nicholas G Cost, Jonathan H Ross, Fernando A Ferrer, Armando J Lorenzo, Margarett Shnorhavorian, Jonathan C Routh, Kathleen Kieran, Michael L Ritchey
PURPOSE: Objective data on patterns of oncology practice amongst pediatric urologists are lacking. Thus, we reviewed surgical case-logs submitted to the American Board of Urology (ABU) by those self-reporting as pediatric urologists. We hypothesized that logs would report a low oncology volume (<5 cases), would identify orchiectomy as the most common oncology case, and that <25% of logs would report a nephrectomy for renal tumors. METHODS: Case-logs submitted for ABU certification, re-certification or pediatric subspecialty certification (PSCE) were reviewed and standardized to represent 12mo practice...
December 13, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27929699/elucidating-trainee-effect-on-outcomes-for-general-gynecologic-and-urologic-oncology-procedures
#14
Megan Sippey, Konstantinos Spaniolas, Kevin R Kasten
BACKGROUND AND OBJECTIVES: Surgical complications delay adjuvant therapy in oncology patients. Current literature remains unclear regarding resident effect on postoperative outcomes, with inappropriate coverage possibly endangering patients in spite of attending oversight. We assessed resident postgraduate year (PGY) effect on 30-day overall morbidity in cancer patients undergoing major intra-abdominal and non-abdominal surgery. METHODS: Patients undergoing non-emergent major intra- and extra-abdominal operations from 2005-2012 were queried using the American College of Surgeons' National Surgical Quality Improvement Program...
December 8, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27889880/the-impact-of-extended-lymph-node-dissection-versus-neoadjuvant-therapy-with-limited-lymph-node-dissection-on-biochemical-recurrence-in-high-risk-prostate-cancer-patients-treated-with-radical-prostatectomy-a-multi-institutional-analysis
#15
Takuma Narita, Takuya Koie, Teppei Ookubo, Koji Mitsuzuka, Shintaro Narita, Hayato Yamamoto, Takamitsu Inoue, Shingo Hatakeyama, Sadafumi Kawamura, Tatsuo Tochigi, Tomonori Habuchi, Yoichi Arai, Chikara Ohyama
The optimal treatment for high-risk prostate cancer (Pca) remains to be established. The current guidelines recommend extended pelvic lymph node dissection (e-PLND) for selected intermediate- and high-risk patients treated with RP. However, the indications, optimal extent, and therapeutic benefits of e-PLND remain unclear. The aim of this study was to assess whether e-PLND confers an oncological benefit for high-risk Pca compared to neoadjuvant luteinizing hormone-releasing hormone and estramustine (LHRH + EMP)...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27884539/intravesical-chemotherapy-use-after-radical-nephroureterectomy-a-national-survey-of-urologic-oncologists
#16
Diane D Lu, Stephen A Boorjian, Jay D Raman
: To determine the use of prophylactic intravesical chemotherapy (pIVC) following radical nephroureterectomy (RNU) and barriers to utilization in a survey study of urologic oncologists. METHODS: A survey instrument was constructed, which queried respondents on professional experience, practice environment, pIVC use, and reasons for not recommending pIVC when applicable. The survey was electronically distributed to members of the Society of Urologic Oncology over an 8-week period...
November 21, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27872478/circulating-tumour-cells-as-biomarkers-of-prostate-bladder-and-kidney-cancer
#17
REVIEW
Michael A Gorin, James E Verdone, Emma van der Toom, Trinity J Bivalacqua, Mohamad E Allaf, Kenneth J Pienta
Circulating tumour cells (CTCs) have been studied as biomarkers of a number of solid malignancies. Potential clinical applications for CTC analysis include early cancer detection, disease staging, monitoring for recurrence, prognostication, and to aid in the selection of therapy. In the field of urologic oncology, CTCs have been most widely studied as prognostic biomarkers of castration-resistant prostate cancer. Additionally, emerging data support a role for CTCs to help identify which patients are most likely to respond to novel androgen-pathway targeted therapies, such as abiraterone and enzalutamide...
November 22, 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27862367/clinical-benefits-of-frozen-section-assessment-during-urological-surgery-does-it-contribute-to-improving-surgical-margin-status-and-patient-outcomes-as-previously-thought
#18
REVIEW
Hiroshi Miyamoto
Despite significant advances in patient selection as well as surgical technique over the past few decades, it is still not uncommon for patients with urological malignancy and positive surgical margins to be observed. Meanwhile, intraoperative pathology consultation with frozen section assessment, which generally provides useful information for the optimal procedure, has been widely utilized for the assessment of surgical margins during urological surgeries. Thus, it remains unanswered whether intraoperative frozen section assessment has an impact on final surgical margin status as well as long-term oncological outcomes...
November 8, 2016: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#19
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27843593/diagnosis-and-treatment-of-bone-metastasis-comprehensive-guideline-of-the-japanese-society-of-medical-oncology-japanese-orthopedic-association-japanese-urological-association-and-japanese-society-for-radiation-oncology
#20
REVIEW
H Shibata, S Kato, I Sekine, K Abe, N Araki, H Iguchi, T Izumi, Y Inaba, I Osaka, S Kato, A Kawai, S Kinuya, M Kodaira, E Kobayashi, T Kobayashi, J Sato, N Shinohara, S Takahashi, Y Takamatsu, K Takayama, K Takayama, U Tateishi, H Nagakura, M Hosaka, H Morioka, T Moriya, T Yuasa, T Yurikusa, K Yomiya, M Yoshida
Diagnosis and treatment of bone metastasis requires various types of measures, specialists and caregivers. To provide better diagnosis and treatment, a multidisciplinary team approach is required. The members of this multidisciplinary team include doctors of primary cancers, radiologists, pathologists, orthopaedists, radiotherapists, clinical oncologists, palliative caregivers, rehabilitation doctors, dentists, nurses, pharmacists, physical therapists, occupational therapists, medical social workers, etc. Medical evidence was extracted from published articles describing meta-analyses or randomised controlled trials concerning patients with bone metastases mainly from 2003 to 2013, and a guideline was developed according to the Medical Information Network Distribution Service Handbook for Clinical Practice Guideline Development 2014...
2016: ESMO Open
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