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Urologic oncology

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https://www.readbyqxmd.com/read/28922687/comparison-of-perioperative-renal-and-oncologic-outcomes-in-robotic-assisted-versus-open-partial-nephrectomy
#1
Jo-Lynn Tan, Mark Frydenberg, Jeremy Grummet, Uri Hanegbi, Ross Snow, Sarah Mann, Kirobel Begashaw, Daniel Moon
BACKGROUND: To compare perioperative, renal and oncological outcomes after robotic-assisted partial nephrectomy (RAPN) versus open partial nephrectomy (OPN) for the treatment of renal tumours. METHODS: All partial nephrectomies performed at a Metropolitan Urology Centre between 2010 and 2016 were analysed. Baseline data was collected for patient demographics, tumour characteristics (tumour size, laterality and polarity, RENAL scores), and perioperative variables (e...
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28921833/guideline-of-guidelines-asymptomatic-microscopic-haematuria
#2
REVIEW
Brian J Linder, Edward J Bass, Hugh Mostafid, Stephen A Boorjian
OBJECTIVE: To review major organizational guidelines on the evaluation and management of asymptomatic microscopic haematuria (AMH). METHODS: This is a review of the haematuria guidelines from 1.) American Urological Association (AUA), 2.) consensus statement from the Canadian Urological Association, Canadian Urologic Oncology Group, and Bladder Cancer Canada, 3.) American College of Physicians (ACP), 4.) Joint Consensus Statement of the Renal Association (RA) and British Association of Urological Surgeons (BAUS), and 5...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28911923/secondary-data-sources-for-health-services-research-in-urologic-oncology
#3
REVIEW
Alexander P Cole, David F Friedlander, Quoc-Dien Trinh
BACKGROUND: Though secondary data analyses of large datasets may reduce logistical and financial barriers required to perform significant and innovative work, such research requires specialized skills in data handling and statistical techniques as well as thorough and detailed knowledge of the data sources being used. OBJECTIVES: To provide an overview of several common types of secondary data, focusing on strengths, weaknesses and examples of how these data may be used for health services research...
September 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#4
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28895564/frontiers-in-robot-assisted-retroperitoneal-oncological-surgery
#5
REVIEW
Wesley W Ludwig, Michael A Gorin, Phillip M Pierorazio, Mohamad E Allaf
Robot assistance has been rapidly adopted by urological surgeons and has become particularly popular for oncological procedures involving the retroperitoneal space. The wide dissemination of robot assistance probably reflects the limited amount of operating space available within the retroperitoneum and the advantages provided by robot-assisted approaches, including 3D imaging, wristed instrumentation and the shorter learning curve compared with that associated with the equivalent laparoscopic techniques. Surgical procedures that have traditionally been performed using an open or laparoscopic approach, such as partial nephrectomy, radical nephrectomy, retroperitoneal lymph node dissection, nephroureterectomy and adrenalectomy, are now often being performed using robot assistance...
September 12, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28890901/performing-all-major-surgical-procedures-robotically-will-prolong-wait-times-for-surgery
#6
Brian M Shinder, Nicholas J Farber, Robert E Weiss, Thomas L Jang, Isaac Y Kim, Eric A Singer, Sammy E Elsamra
This article aimed to assess the burden of scheduling major urologic oncology procedures if all cases were performed robotically and to determine whether this would increase the time a patient would have to wait for surgery. We retrospectively determined the number of prostatectomies, radical nephrectomies, partial nephrectomies, and cystectomies at a single institution for one calendar year. A hypothetical situation was then constructed where all procedures were performed robotically. Using the allotted number of days that each surgeon was able to schedule robotic procedures, we analyzed the amount of time it would take to schedule and complete all cases...
2017: Robot Surg
https://www.readbyqxmd.com/read/28889385/the-n-butyl-n-4-hydroxybutyl-nitrosamine-mouse-urinary-bladder-cancer-model
#7
Paula A Oliveira, Cármen Vasconcelos-Nóbrega, Rui M Gil da Costa, Regina Arantes-Rodrigues
Urinary bladder cancer (UBC) is a common and complex malignancy, with a multifactorial etiology, like environmental factors, such as cigarette smoking, occupational exposure, and genetic factors.UBC exhibits considerable genotypic and phenotypic heterogeneity. Among all UBC lesions, urothelial carcinoma is the most frequently observed histological type. Despite all the developments made in urologic oncology field, therapeutic options remain inadequate. There is urgency for the identification and development of new antineoplastic drugs to replace or improve current protocols and in vivo models have been proven to be essential for this step...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28887095/psychological-distress-in-patients-undergoing-surgery-for-urological-cancer-a-single-centre-cross-sectional-study
#8
Antonio Luigi Pastore, Ana Mir, Serena Maruccia, Giovanni Palleschi, Antonio Carbone, Cristina Lopez, Nuria Camps, Joan Palou
PURPOSE: Interest in the disease-specific psychological well-being of patients with cancer has increased, and it has been estimated that less than half of all patients with cancer are properly identified and subsequently treated for anxiety or depression. The aim of this study is to evaluate psychological distress in uro-oncological patients undergoing different surgeries: radical cystectomy, radical prostatectomy, radical nephrectomy, or transurethral resection (TUR) before the surgery...
September 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28869204/safety-of-live-robotic-surgery-results-from-a-single-institution
#9
Gabriel Ogaya-Pinies, Haidar Abdul-Muhsin, Hariharan Palayapalayam-Ganapathi, Xavier Bonet, Travis Rogers, Bernardo Rocco, Rafael Coelho, Eduardo Hernandez-Cardona, Cathy Jenson, Vipul Patel
BACKGROUND: Live surgery events (LSEs) have become one of the most attended activities at surgical meetings and provide a unique opportunity for the audience to observe the decision-making process used by skilled and experienced surgeons in real time. However, there is an ongoing discussion on whether patients treated during LSE are at higher risk of complications. OBJECTIVE: To examine LSE outcomes for robot-assisted radical prostatectomy (RARP) and establish patient safety and efficacy...
August 28, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28867431/race-and-postoperative-complications-following-urologic-cancer-surgery-an-acs-nsqip-analysis
#10
Daniel C Parker, Elizabeth Handorf, Marc C Smaldone, Robert G Uzzo, Henry Pitt, Adam C Reese
PURPOSE: Racial disparities in complication rates have been demonstrated for a variety of surgical procedures. We hypothesized that African American (AA) patients experience higher postoperative complication rates than whites following urologic oncology procedures. MATERIALS AND METHODS: Patients in American College of Surgeons National Surgical Quality Improvement Program who underwent radical prostatectomy (RP), radical or partial nephrectomy (RN/PN), and radical cystectomy (RC) between 2005 and 2013 were included...
August 31, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28865709/minilaparoscopy-in-urology-systematic-review
#11
A Pérez-Lanzac, R García-Baquero
CONTEXT: There has been a boom in recent years in urological procedures using minilaparoscopy (ML). OBJECTIVE: To conduct a systematic review of the published evidence on ML and its current role in urology. ACQUISITION OF EVIDENCE: We performed a search on MedLine spanning October 1983 to December 2016 according to PRISMA criteria. A total of 6 comparative articles and 13 series were selected for this manuscript. SUMMARY OF THE EVIDENCE: Only 1 study was randomised, 4 studies were prospective and comparative, and most were case series in which the operations were performed with 3-mm instruments...
August 30, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28851578/moving-towards-precision-urologic-oncology-targeting-enzalutamide-resistant-prostate-cancer-and-mutated-forms-of-the-androgen-receptor-using-the-novel-inhibitor-darolutamide-odm-201
#12
Hendrik Borgmann, Nada Lallous, Deniz Ozistanbullu, Eliana Beraldi, Naman Paul, Kush Dalal, Ladan Fazli, Axel Haferkamp, Pascale Lejeune, Artem Cherkasov, Martin E Gleave
Darolutamide (ODM-201) is a novel androgen receptor (AR) antagonist with a chemical structure distinctly different from currently approved AR antagonists that targets both wild-type and mutated ligand binding domain variants to inhibit AR nuclear translocation. Here, we evaluate the activity of darolutamide in enzalutamide-resistant castration resistant prostate cancer (CRPC) as well as in AR mutants detected in patients after treatment with enzalutamide, abiraterone, or bicalutamide. Darolutamide significantly inhibited cell growth and AR transcriptional activity in enzalutamide-resistant MR49F cells in vitro, and led to decreased tumor volume and serum prostate-specific antigen levels in vivo, prolonging survival in mice bearing enzalutamide-resistant MR49F xenografts...
August 26, 2017: European Urology
https://www.readbyqxmd.com/read/28840090/cold-atmospheric-plasma-in-orthopaedic-and-urologic-tumor-therapy
#13
REVIEW
Denis Gümbel, Georg Daeschlein, Axel Ekkernkamp, Axel Kramer, Matthias B Stope
Cold atmospheric plasma (CAP) is a highly reactive ionized physical state thereby provoking divers biological effects. In medical applications, CAP treatment promotes wound healing, provokes immunostimulation, and is antiseptically active. Moreover, CAP interacts with antiproliferative mechanisms suggesting CAP treatment as a promising anticancer strategy. Here we review the current state of science concerning the so far investigated CAP effects on different cancer entities in orthopaedic and urologic oncology...
2017: GMS Hygiene and Infection Control
https://www.readbyqxmd.com/read/28836985/providing-guidance-for-genomics-based-cancer-treatment-decisions-insights-from-stakeholder-engagement-for-post-prostatectomy-radiation-therapy
#14
James Abe, Jennifer M Lobo, Daniel M Trifiletti, Timothy N Showalter
BACKGROUND: Despite the emergence of genomics-based risk prediction tools in oncology, there is not yet an established framework for communication of test results to cancer patients to support shared decision-making. We report findings from a stakeholder engagement program that aimed to develop a framework for using Markov models with individualized model inputs, including genomics-based estimates of cancer recurrence probability, to generate personalized decision aids for prostate cancer patients faced with radiation therapy treatment decisions after prostatectomy...
August 24, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28822555/influence-of-tumor-size-on-outcomes-following-pelvic-exenteration
#15
B Smith, E L Jones, M Kitano, A L Gleisner, N J Lyell, G Cheng, M D McCarter, S Abdel-Misih, F J Backes
OBJECTIVE: Pelvic exenteration (PE) is often the only curative option for locally advanced or recurrent pelvic malignancies. Despite radical surgery, recurrence risk and morbidity remain high. In this study, we sought to determine tumor size effect on perioperative outcomes and subsequent survival in patients undergoing PE. METHODS: Retrospective chart review was performed for female patients who underwent PE at two comprehensive cancer centers from 2000 to 2015...
August 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28813037/concomitant-bladder-cancer-and-prostate-cancer-challenges-and-controversies
#16
REVIEW
Antonio Lopez-Beltran, Liang Cheng, Francesco Montorsi, Maria Scarpelli, Maria R Raspollini, Rodolfo Montironi
Radical cystoprostatectomy (RCP) followed by bilateral pelvic lymphadenectomy and urinary diversion remains the gold-standard therapy for men with localized muscle-invasive bladder cancer (MIBC). Prostate cancer might be incidentally detected at the time of RCP with a reported prevalence of 24-51%. Typically, these patients are considered to have clinically insignificant disease, but data from emerging series challenge this assumption and suggest that some of these tumours might be aggressive, or somehow increase the aggressiveness of the associated MIBC, and can negatively influence the patient's overall survival outcomes...
August 16, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28803033/the-risk-of-tumour-recurrence-in-patients-undergoing-renal-transplantation-for-end-stage-renal-disease-after-previous-treatment-for-a-urological-cancer-a-systematic-review
#17
REVIEW
Romain Boissier, Vital Hevia, Harman Max Bruins, Klemens Budde, Arnaldo Figueiredo, Enrique Lledó-García, Jonathon Olsburgh, Heinz Regele, Claire Fraser Taylor, Rhana Hassan Zakri, Cathy Yuhong Yuan, Alberto Breda
CONTEXT: Renal transplantation is the gold standard renal replacement therapy in end-stage renal disease owing to its superior survival and quality of life compared with dialysis. When the potential recipient has a history of cancer, the waiting period before renal transplantation is usually based on the Cincinnati Registry. OBJECTIVE: To systematically review all available evidence on the risk of cancer recurrence in end-stage renal disease patients with a history of urological cancer...
August 10, 2017: European Urology
https://www.readbyqxmd.com/read/28802569/gender-and-subspecialty-of-urology-faculty-in-department-based-leadership-roles
#18
Julia Han, Stephanie Stillings, Harold Hamann, Russell Terry, Louis Moy
OBJECTIVE: To characterize the current gender and subspecialty of those holding academic departmental administrative and educational leadership roles in urology. METHODS: We conducted a cross-sectional observational study of U.S. Urology Residency Programs in 2016-2017. Inclusion criteria were participation in the Urology Residency Match Program and having a department of urology website. From June 1, 2016 to August 20, 2016, each department's website was queried...
August 9, 2017: Urology
https://www.readbyqxmd.com/read/28797228/oncological-outcomes-in-an-australian-cohort-according-to-the-new-prostate-cancer-grading-groupings
#19
K R Beckmann, A D Vincent, M E O'Callaghan, P Cohen, S Chang, M Borg, S M Evans, D M Roder, K L Moretti
BACKGROUND: A new 5-tiered grading grouping system has recently been endorsed for reporting of prostate cancer (PCa) grade to better reflect escalating risk of progression and cancer death. While several validations of the new grade groupings have been undertaken, most have involved centralised pathological review by specialist urological pathologists. METHODS: Participants included 4268 men with non-metastatic PCa diagnosed between 2006 and 2013 from the multi-institutional South Australia Prostate Cancer Clinical Outcomes Collaborative registry...
August 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28796558/treatment-of-nonmetastatic-muscle-invasive-bladder-cancer-american-urological-association-american-society-of-clinical-oncology-american-society-for-radiation-oncology-society-of-urologic-oncology-clinical-practice-guideline-summary
#20
Sam S Chang, Bernard H Bochner, Roger Chou, Robert Dreicer, Ashish M Kamat, Seth P Lerner, Yair Lotan, Joshua J Meeks, Jeff M Michalski, Todd M Morgan, Diane Z Quale, Jonathan E Rosenberg, Anthony L Zietman, Jeffrey M Holzbeierlein
No abstract text is available yet for this article.
September 2017: Journal of Oncology Practice
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