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dextrose in postoperative period

Ranjana Khetarpal, Veena Chatrath, Jagjit Kaur, Anju Bala, Harjeet Singh
BACKGROUND: Intravenous (IV) fluids are an integral part of perioperative management. Intraoperative hyperglycemia is associated with poor clinical outcomes in patients undergoing major surgeries even in nondiabetics. AIM: This study was conducted to observe the effect of different maintenance fluid regimens on intraoperative blood glucose levels in nondiabetic patients undergoing major surgeries under general anesthesia. SETTINGS AND DESIGN: Randomized double-blind study...
September 2016: Anesthesia, Essays and Researches
Benjamin Harris, Christian Schopflin, Clare Khaghani, Mark Edwards
BACKGROUND: Excessive or inadequate intravenous fluid given in the perioperative period can affect outcomes. A number of guidelines exist but these can conflict with the entrenched practice, evidence base and prescriber knowledge. We conducted a multi-centre audit of intraoperative and postoperative intravenous fluid therapy to investigate fluid administration practice and frequency of postoperative electrolyte disturbances. METHODS: A retrospective audit was done in five hospitals of adult patients undergoing elective major abdominal, gastrointestinal tract or orthopaedic surgery...
2015: Perioperative Medicine
A M Mehta, J M Van den Hoven, H Rosing, M J X Hillebrand, B Nuijen, A D R Huitema, J H Beijnen, V J Verwaal
PURPOSE: Oxaliplatin is increasingly becoming the chemotherapeutic drug of choice for the treatment of peritoneal malignancies using cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). Oxaliplatin is unstable in chloride-containing media, resulting in the use of 5% dextrose as the carrier solution in these procedures. Exposure of the peritoneum to 5% dextrose during perfusion times varying from 30 min to 90 min is associated with serious hyperglycemias and electrolyte disturbances...
February 1, 2015: International Journal of Pharmaceutics
Hsiu-Hua Huang, Pi-Chuan Wu, Shiu-Ping Kang, Jui-Ho Wang, Chien-Wei Hsu, Leh-Chii Chwang, Sue-Joan Chang
To assess clinical efficacy of using postoperative branched-chain amino acids (BCAAs)-enriched nutritional support in lower gastrointestinal cancer patients, we conducted a retrospective observational study comparing this regimen with traditional fluid management. Sixty-one eligible colorectal cancer patients consecutively admitted in the Colorectal Surgery Ward to receive postoperative hypocaloric peripheral parenteral nutrition (HPPN) were categorized into dextrose-only control group (n = 20), dextrose plus low-dose BCAA fat group (n = 20), and dextrose plus high-dose BCAA fat group (n = 21)...
2014: Nutrition and Cancer
K K Mukherjee, Pinaki Dutta, Apinderpreet Singh, Prakamya Gupta, Anand Srinivasan, Hemant Bhagat, S N Mathuriya, Viral N Shah, Anil Bhansali
BACKGROUND: Electrolyte imbalance and acute diabetes insipidus (DI) are the most common complications in patients undergoing craniopharyngioma surgery. Improper management of water and electrolyte imbalance is common cause of morbidity and mortality. Data is sparse and controversial regarding the choice of fluid therapy in this population during perioperative period. METHODS: In this retrospective-prospective study involving 73 patients (58 retrospective), the type of fluid therapy was correlated with occurrence of hypernatremia, hyponatremia, DI, morbidity, and mortality...
2014: Surgical Neurology International
Fatih Kahraman, Ahmet Eroglu
AIM: The aim of this study was to investigate the effect of i.v. infusion of magnesium sulphate during spinal anesthesia on duration of spinal block and postoperative pain. METHODS: Forty ASA physical status I and status II, aged between 18 and 65, female patients undergoing abdominal hysterectomy under spinal anesthesia were enrolled in this study. Patients in the magnesium group (Group M, n = 20) received magnesium sulphate 65 mg kg(-1) infusion in 250 mL 5% dextrose at 3...
2014: BioMed Research International
Yalda Jabbari Moghaddam, Mahin Seyedhejazi, Mosoud Naderpour, Yoosef Yaghooblua, Samad E J Golzari, Samad Golzary
BACKGROUND: Adenotonsillectomy is a common otolaryngology surgery. Nausea and vomiting are the most common complications of this procedure with a prevalence ranging from 49% to 73 %. OBJECTIVES: Our aim was to evaluate the effects of short time fasting protocol on decreasing postoperative pain, nausea and vomiting, and initiation of oral feeding after adenotonsillectomy. PATIENTS AND METHODS: 120 children aged 4 to 14 years candidates for adenotonsillectomy were randomly divided into intervention and control groups (n = 120, 60 in each group)...
February 2014: Anesthesiology and Pain Medicine
Mary Ellen McCann, A N J Schouten, Nicole Dobija, Carlos Munoz, Lianne Stephenson, Tina Y Poussaint, C J Kalkman, Paul R Hickey, Linda S de Vries, Robert C Tasker
We report on 6 infants who underwent elective surgery and developed postoperative encephalopathy, which had features most consistent with intraoperative cerebral hypoperfusion. All infants were <48 weeks' postmenstrual age and underwent procedures lasting 120 to 185 minutes. Intraoperative records revealed that most of the measured systolic blood pressure (SBP) values were <60 mm Hg (the threshold for hypotension in awake infants according to the Pediatric Advanced Life Support guidelines) but that only 11% of the measured SBP values were <1 SD of the mean definition of hypotension (<45 mm Hg) as reported in a survey of members of the Society for Pediatric Anesthesia in 2009...
March 2014: Pediatrics
Parul Patel, Minhthy N Meineke, Thomas Rasmussen, Donald L Anderson, Jennifer Brown, Sam Siddighi, Richard L Applegate
BACKGROUND: Postoperative nausea and vomiting (PONV) may occur despite antiemetic prophylaxis and is associated with unanticipated hospital admission, financial impact, and patient dissatisfaction. Previous studies have shown variable impact of IV dextrose on PONV. We sought to determine the relationship of IV dextrose administered during emergence from anesthesia to PONV. METHODS: This was a prospective, double-blind randomized placebo-controlled trial. Adult female ASA physical status I and II nondiabetic patients scheduled for outpatient gynecologic, urologic, or breast surgery were randomly assigned to infusion of 250 mL lactated Ringer's solution (group P; n = 75) or dextrose 5% in lactated Ringer's solution (group D; n = 87) over 2 hours beginning with surgical closing...
July 2013: Anesthesia and Analgesia
Cem Ungor, Kerem Turgut Atasoy, Fatih Taskesen, Burak Cezairli, Ezher Hamza Dayisoylu, Emre Tosun, Figen Cizmeci Senel
OBJECTIVE: Prolotherapy, the rehabilitation of ligaments or tendons by induced proliferation of cells by using dextrose, is a noninvasive and effective method for the treatment of temporomandibular joint (TMJ) dislocation. The aim of this study was to evaluate the efficacy of prolotherapy method for the management of acute or chronic dislocation of TMJ. MATERIALS AND METHODS: In this study, 10 patients with TMJ dislocation (2 acute, 8 chronic) were examined retrospectively...
March 2013: Journal of Craniofacial Surgery
Dhananjay Shukla, Jay Kalliath, Aditi Patwardhan, Naresh B Kannan, Soubhya B Thayyil
CONTEXT: Surgical outcomes of vitrectomy for idiopathic macular hole using a "heavy" Brilliant Blue G (HBBG) solution for staining and removal of the internal limiting membrane (ILM). SETTINGS AND DESIGN: Prospective interventional case series conducted in a tertiary eye care hospital. MATERIALS AND METHODS: Nineteen patients (20 eyes) with idiopathic macular hole were enrolled to undergo vitrectomy with ILM peeling using HBBG. BBG dye was made heavy by mixing with 10% dextrose normal saline (DNS) solution in 2:1 ratio...
November 2012: Indian Journal of Ophthalmology
Yong Liu, Yang Yang, Hui Liu, Yunjun Song, Xihua Jia, Xiaowei Zhang, Jianmei Guo
OBJECTIVE: To investigate the mechanisms of local application of granulocyte macrophage-colony stimulating factor (GM-CSF) on healing of colonic anastomoses impaired by intraperitoneal oxaliplatin in rats. METHODS: Sixty 10-week-old male Wistar rats were made the colonic anastomosis model and randomized into 3 groups, 20 rats in each. The rats received intraperitoneal injection of 5% dextrose in group A, and intraperitoneal injection of 5% dextrose and 10 mL oxaliplatin (25 mg/kg) in group B at 1 day; and 50 microg GM-CSF was injected into the perianastomotic area immediately after operation and 10 mL intraperitoneal oxaliplatin (25 mg/kg) was given at 1 day...
October 2012: Chinese Journal of Reparative and Reconstructive Surgery
Mehmet B Sentürk, Yusuf Cakmak, Gazi Yildiz, Pınar Yildiz
PURPOSE: To assess the efficacy and safety of an intravenous formulation of tranexamic acid to reduce intrapartum and postpartum bleeding in patients giving birth by cesarean section. METHODS: Healthy women with normal pregnancies, at any gestational age, that we performed ceaserean section. Two hundred and twenty-three patients with cesarean section, were enrolled in a double-blind, placebo-controlled study. Tranexamic acid of 20 cc and a 20 cc 5 % dextrose solution was intravenously injected to the patients; both the study group (n = 101) and the control group (n = 122) 10 min before the start of cesarean section...
April 2013: Archives of Gynecology and Obstetrics
Huan-rong Qiu, Shou-yuan Tian, Tie-hu Ye, Bo Zhu
OBJECTIVE: To audite and compare the perioperative practices of intravenous fluids and electrolyte & glucose monitoring in children undergoing operations for scoliosis in 2008, 2010, prior to and after the publication of guideline in 2009. METHODS: Retrospective audit was conducted at Peking Union Medical College Hospital, a tertiary referral teaching hospital in Beijing, China. Children under 14 years old with scoliosis treated surgically in 2008 and 2010 were recruited...
April 3, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Mark G Coulthard, Debbie A Long, Amanda J Ullman, Robert S Ware
OBJECTIVE: To compare the difference in plasma sodium at 16-18 h following major surgery in children who were prescribed either Hartmann's and 5% dextrose or 0.45% saline and 5% dextrose. DESIGN: A prospective, randomised, open label study. SETTING: The paediatric intensive care unit (650 admissions per annum) in a tertiary children's hospital in Brisbane, Australia. PATIENTS: The study group comprised 82 children undergoing spinal instrumentation, craniotomy for brain tumour resection, or cranial vault remodelling...
June 2012: Archives of Disease in Childhood
Mahnoosh Foroughi, Hossein Rahimian, Ali Dabbagh, Masood Majidi, Manoucher Hekmat, Mahmood Beheshti, Mehran Shahzamani
OBJECTIVE: The aim of this study was to clarify the efficacy of perioperative glucose-insulin-potassium (GIK) infusion on preoperative and postoperative N-terminal (NT)-pro-brain natriuretic peptide (BNP) concentrations in patients with a low ejection fraction undergoing isolated on-pump coronary artery bypass graft (CABG) surgery. DESIGN: A double-blind, randomized, controlled study. SETTING: Modarres Hospital, Tehran, Islamic Republic of Iran...
August 2012: Journal of Cardiothoracic and Vascular Anesthesia
Andrea Kopp Lugli, Francesco Donatelli, Thomas Schricker, Christoph H Kindler, Linda Wykes, Franco Carli
Loss of body protein and hyperglycaemia represent typical features of the stress response to surgery and anaesthesia. This appears to be particularly pronounced in patients with diabetes mellitus type 2. The aim of the present study was to highlight the greater benefit of amino acids (AA) as represented by positive protein balance and maintenance of blood glucose homoeostasis compared with dextrose (DEX) in diabetic patients after colorectal surgery. A total of thirteen patients underwent a 5 h stable isotope infusion study (2 h fasted, 3 h fed with an infusion of AA (n 6) or DEX (n 7)) on the second post-operative day...
February 2012: British Journal of Nutrition
Marie-Christine Ross-Huot, André Laferrière, Cho Min Gi, Mina Khorashadi, Thomas Schricker, Terence J Coderre
BACKGROUND: Ischemia-reperfusion (I/R) injuries consist of enhanced oxidative and inflammatory responses along with microvascular dysfunction after prolonged ischemia and reperfusion. Because I/R injuries induce chronic postischemia pain (CPIP) in laboratory animals, it is possible that surgical procedures using prolonged ischemia may result in chronic postoperative pain. Glycemic modulation during ischemia and reperfusion could affect pain after I/R injury because glucose triggers oxidative, inflammatory, and thrombotic reactions, whereas insulin has antioxidative, antiinflammatory, and vasodilatory properties...
September 2011: Anesthesiology
Hamida Refai, Obada Altahhan, Rehab Elsharkawy
PURPOSE: The aim of this study was to assess the efficacy of dextrose prolotherapy for the treatment of temporomandibular joint (TMJ) hypermobility. PATIENTS AND METHODS: A prospective, randomized, double-blind clinical study using a placebo control was carried out. Twelve patients with painful subluxation or dislocation of the TMJ were randomly assigned to 1 of 2 equal-sized groups. Patients in the active group received 4 injections of dextrose solution (2 mL of 10% dextrose and 1 mL of 2% mepivacaine) for each TMJ, each 6 weeks apart, whereas patients in the placebo group received injections of placebo solution (2 mL of saline solution and 1 mL of 2% mepivacaine) on the same schedule...
December 2011: Journal of Oral and Maxillofacial Surgery
M Emirleroglu, B Ekci, V Durgun
OBJECTIVES: The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses. BACKGROUND: Anastomotic leaks and postoperative ileus are among the most important complications in colorectal surgery. Nutritional status of the patient is one of the most important factors of the anastomoses healing. METHODS: Forty Wistar-albino rats were randomly assigned to (1) colon anastomoses + protein-enriched diet + 1 microg neostigmine, (2) colon anastomoses + protein-enriched diet, (3) colon anastomoses + 30 % dextrose + 1 microg neostigmine, (4) colon anastomoses + 30% dextrose...
2011: Bratislavské Lekárske Listy
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