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https://www.readbyqxmd.com/read/29352626/differences-between-sexes-in-the-standard-and-advanced-dimensioning-of-lateral-meniscal-allografts
#1
Patrycja Mickiewicz, Michał Walczak, Michał Łaszczyca, Damian Kusz, Zygmunt Wróbel
BACKGROUND: There are many different methods of meniscal allograft measurements, which depend on individual tissue bank procedures. Due to the lack of a standardised method of dimensioning, measurement results may vary between individual cases. Consequently, allograft may be mismatched to the patient's knee anatomy. The purpose of this study was to measure four meniscal dimensions - two standard and two specific - and then compare them between sexes. METHODS: Fourteen cadaveric lateral menisci (seven male and seven female) were scanned using a microtomography scanner...
January 15, 2018: Knee
https://www.readbyqxmd.com/read/29351654/what-is-the-role-of-imaging-in-the-clinical-diagnosis-of-osteoarthritis-and-disease-management
#2
Xia Wang, Win Min Oo, James M Linklater
While OA is predominantly diagnosed on the basis of clinical criteria, imaging may aid with differential diagnosis in clinically suspected cases. While plain radiographs are traditionally the first choice of imaging modality, MRI and US also have a valuable role in assessing multiple pathologic features of OA, although each has particular advantages and disadvantages. Although modern imaging modalities provide the capability to detect a wide range of osseous and soft tissue (cartilage, menisci, ligaments, synovitis, effusion) OA-related structural damage, this extra information has not yet favourably influenced the clinical decision-making and management process...
January 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29311146/impact-of-broad-regulatory-regions-on-gdf5-expression-and-function-in-knee-development-and-susceptibility-to-osteoarthritis
#3
Steve K Pregizer, Ata M Kiapour, Mariel Young, Hao Chen, Michael Schoor, Zun Liu, Jiaxue Cao, Vicki Rosen, Terence D Capellini
OBJECTIVES: Given the role of growth and differentiation factor 5 (GDF5) in knee development and osteoarthritis risk, we sought to characterise knee defects resulting from Gdf5 loss of function and how its regulatory regions control knee formation and morphology. METHODS: The brachypodism (bp) mouse line, which harbours an inactivating mutation in Gdf5, was used to survey how Gdf5 loss of function impacts knee morphology, while two transgenic Gdf5 reporter bacterial artificial chromosome mouse lines were used to assess the spatiotemporal activity and function of Gdf5 regulatory sequences in the context of clinically relevant knee anatomical features...
January 8, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29304778/inflammation-and-glucose-homeostasis-are-associated-with-specific-structural-features-among-adults-without-knee-osteoarthritis-a-cross-sectional-study-from-the-osteoarthritis-initiative
#4
Alina C Stout, Mary F Barbe, Charles B Eaton, Mamta Amin, Fatimah Al-Eid, Lori Lyn Price, Bing Lu, Grace H Lo, Ming Zhang, Jincheng Pang, Timothy E McAlindon, Jeffrey B Driban
BACKGROUND: Greater age and body mass index are strong risk factors for osteoarthritis (OA). Older and overweight individuals may be more susceptible to OA because these factors alter tissue turnover in menisci, articular cartilage, and bone via altered glucose homeostasis and inflammation. Understanding the role of inflammation and glucose homeostasis on structural features of early-stage OA may help identify therapeutic targets to delay or prevent the onset of OA among subsets of adults with these features...
January 5, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29275548/optical-spectroscopic-characterization-of-human-meniscus-biomechanical-properties
#5
Juho Ala-Myllymäki, Elvis K Danso, Juuso T J Honkanen, Rami K Korhonen, Juha Töyräs, Isaac O Afara
This study investigates the capacity of optical spectroscopy in the visible (VIS) and near-infrared (NIR) spectral ranges for estimating the biomechanical properties of human meniscus. Seventy-two samples obtained from the anterior, central, and posterior locations of the medial and lateral menisci of 12 human cadaver joints were used. The samples were subjected to mechanical indentation, then traditional biomechanical parameters (equilibrium and dynamic moduli) were calculated. In addition, strain-dependent fibril network modulus and permeability strain-dependency coefficient were determined via finite-element modeling...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29275250/porous-micropillar-structures-for-retaining-low-surface-tension-liquids
#6
Damena D Agonafer, Hyoungsoon Lee, Pablo A Vasquez, Yoonjin Won, Ki Wook Jung, Srilakshmi Lingamneni, Binjian Ma, Li Shan, Shuai Shuai, Zichen Du, Tanmoy Maitra, James W Palko, Kenneth E Goodson
The ability to manipulate fluid interfaces, e.g., to retain liquid behind or within porous structures, can be beneficial in multiple applications, including microfluidics, biochemical analysis, and the thermal management of electronic systems. While there are a variety of strategies for controlling the disposition of liquid water via capillarity, such as the use of chemically modified porous adhesive structures and capillary stop valves or surface geometric features, methods that work well for low surface tension liquids are far more difficult to implement...
December 14, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29273257/are-outcomes-after-meniscal-repair-age-dependent-a-systematic-review
#7
REVIEW
Shane D Rothermel, Dallas Smuin, Aman Dhawan
PURPOSE: To determine if the failure rate and functional outcome after arthroscopic meniscus suture repair are age dependent. METHODS: A systematic review was conducted using a computerized search of the electronic databases MEDLINE and ScienceDirect in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Extracted data from each included study were recorded on a standardized form. Studies were included if they (1) were English-language studies in peer-reviewed journals, (2) used a distinct age cut-off to evaluate outcome of meniscal surgery for those above and below the specified cut-off, and (3) used meniscal repairs using suture based technique with inside-out, outside-in, or all-inside techniques...
December 19, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29260438/novel-flat-and-wide-meniscal-repair-material-improves-the-ultimate-load-of-knot-breakage-in-a-porcine-trans-capsular-meniscal-repair-model
#8
Hiroyuki Yokoi, Tatsuo Mae, Ryo Iuchi, Yasuhiro Take, Yuta Tachibana, Kazunori Shimomura, Tomoki Ohori, Konsei Shino, Hideki Yoshikawa, Ken Nakata
BACKGROUND: In the meniscal repair procedures, a high ultimate load capacity and low cyclic creep at the repair site are favorable and lead to good biological incorporation of the tear site after surgery. Previous biomechanical tensile tests of the meniscal sutures have identified the suture knot as the weakest point. We hypothesized that the strength of a suture knot depends on the suture shape, and therefore, we compared three differently shaped suture materials composed of the same material and quantity per length...
December 19, 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29258882/transcriptome-comparison-of-meniscus-from-patients-with-and-without-osteoarthritis
#9
Robert H Brophy, Bo Zhang, Lei Cai, Rick W Wright, Linda J Sandell, Muhammad Farooq Rai
OBJECTIVE: To assess the impact of osteoarthritis (OA) on the meniscus by comparing transcripts and biological processes in the meniscus between patients with and without OA. DESIGN: RNA microarrays were used to identify transcripts differentially expressed (DE) in meniscus obtained from 12 OA and 12 non-OA patients. The non-OA specimens were obtained at the time of arthroscopic partial meniscectomy (APM). Real-time PCR was performed on selected transcripts. Biological processes and gene-networking was examined computationally...
December 16, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29249200/anatomical-variant-of-the-meniscus-related-to-posterior-junction-a-case-report
#10
David Sadigursky, Lucas Cortizo Garcia, Rodrigo Rêgo Martins, Gustavo Castro De Queiroz, Rogério Jamil Fernandes Carneiro, Paulo Oliveira Colavolpe
BACKGROUND: There are several reports on anatomical differences of the meniscus. However, there are only a few reports on abnormalities in both menisci and anatomical differences in anterior cruciate ligament insertions. CASE PRESENTATION: This is a case report of a 36-year-old Hispanic man presenting symptoms, including knee pain, locking, and effusion, with an anatomical abnormality of the menisci corresponding to the fusion of the posterior horns of the menisci in tandem with the insertion of the posterior meniscus fibers in the anterior cruciate ligament...
December 18, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29207986/risk-of-total-subtotal-meniscectomy-for-respective-medial-and-lateral-meniscus-injury-correlation-with-tear-type-duration-of-complaint-age-gender-and-acl-rupture-in-6034-asian-patients
#11
Dong Jiang, Xiao Luo, Yingfang Ao, Xi Gong, Yong-Jian Wang, Hai-Jun Wang, Yu Miao, Nan Li, Ji-Ying Zhang, Jia-Kuo Yu
BACKGROUND: To evaluate the risk factor associated with total or subtotal meniscectomy for respective medial and lateral meniscus injury. METHODS: The data of all the meniscus injured patients undergoing arthroscopy in our institute between January 15th, 2000 and December 31st, 2008 was collected and 6034 patients with 7241 injured menisci met the inclusion criteria. The mean patient age was 33.6 ± 14.9 years and there were 4785 males and 2456 females with 3568 medial and 3673 lateral menisci...
December 5, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29205258/sustained-intra-cartilage-delivery-of-low-dose-dexamethasone-using-a-cationic-carrier-for-treatment-of-post-traumatic-osteoarthritis
#12
A G Bajpayee, R E De la Vega, M Scheu, N H Varady, I A Yannatos, L A Brown, Y Krishnan, T J Fitzsimons, P Bhattacharya, E H Frank, A J Grodzinsky, R M Porter
Disease-modifying osteoarthritis drugs (DMOADs) should reach their intra-tissue target sites at optimal doses for clinical efficacy. The dense, negatively charged matrix of cartilage poses a major hindrance to the transport of potential therapeutics. In this work, electrostatic interactions were utilised to overcome this challenge and enable higher uptake, full-thickness penetration and enhanced retention of dexamethasone (Dex) inside rabbit cartilage. This was accomplished by using the positively charged glycoprotein avidin as nanocarrier, conjugated to Dex by releasable linkers...
December 5, 2017: European Cells & Materials
https://www.readbyqxmd.com/read/29188421/arthroscopic-partial-meniscectomy-in-young-patients-with-symptomatic-discoid-lateral-meniscus-an-average-10-year-follow-up-study
#13
Chang-Rack Lee, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Nam-Ki Kim
INTRODUCTION: The aim of this study is to evaluate mid-to-long-term clinical and radiological outcomes after an arthroscopic partial meniscectomy for symptomatic discoid lateral meniscus (DLM) in young patients and to determine whether degeneration of the residual meniscus and articular cartilage progresses during the follow-up period using magnetic resonance imaging (MRI). MATERIALS AND METHODS: We retrospectively reviewed patients aged ≤ 40 years at surgery who underwent arthroscopic partial meniscectomy for symptomatic DLM and were followed up for ≥ 5 years...
November 29, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29187260/histological-changes-of-the-meniscus-following-an-osteochondral-lesion
#14
G M Peretti, I Tessaro, L Montanari, U Polito, A Di Giancamillo, M Di Giancamillo, A Marmotti, A Montaruli, E Roveda, L Mangiavini
In the last few years, different tissue engineering strategies have been developed for the repair of osteochondral lesions. When the osteochondral scaffold is implanted on the femoral condyle, the meniscus might be affected by the implant and might undergo a progressive degeneration. The aim of our study is to analyze the morphological changes of the meniscus following an osteochondral lesion and the implant of a biphasic scaffold. A critical osteochondral defect was generated in the medial femoral condyle of mature sheep...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29183885/can-we-predict-the-clinical-outcome-of-arthroscopic-partial-meniscectomy-a-systematic-review
#15
REVIEW
Susanne M Eijgenraam, Max Reijman, Sita M A Bierma-Zeinstra, Daan T van Yperen, Duncan E Meuffels
NHS-PROSPERO REGISTRATION NUMBER: 42016048592 OBJECTIVE: In order to make a more evidence-based selection of patients who would benefit the most from arthroscopic partial meniscectomy (APM), knowledge of prognostic factors is essential. We conducted a systematic review of predictors for the clinical outcome following APM. DESIGN: Systematic review DATA SOURCES: Medline, Embase, Cochrane Central Register, Web of Science, SPORTDiscus, PubMed Publisher, Google Scholar INCLUSION CRITERIA: Report an association between factor(s) and clinical outcome; validated questionnaire; follow-up >1 year...
November 28, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29170181/multiple-hybrid-sutures-of-bucket-handle-injury-on-the-lateral-and-medial-meniscus-of-the-knee
#16
Diego Costa Astur, Bruno Silveira Pavei, Camila Cohen Kaleka, Moises Cohen
The objective of the study is to show possibilities of several combinations of suture techniques in a rare bicompartmental bucket handle injury. According to specific injury characteristics, combined suturing techniques were used. The option for different meniscal suture techniques in the two knee compartments allowed the patient, after completing the treatment, to return to his activities with a preserved meniscus. Although meniscectomy continues to be a chosen technique in bucket handle injury, we attempted to show a case of bicompartmental meniscal suture with different techniques...
November 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29145286/bilateral-discoid-medial-meniscus-associated-with-meniscal-tears-and-hypoplasia-of-the-medial-femoral-condyle-a-case-report
#17
Hong-De Wang, Shi-Jun Gao
RATIONALE: Bilateral discoid medial menisci is an extremely rare abnormality of the knee joint. The presence of a discoid medial meniscus has been associated with magnetic resonance imaging (MRI) and radiographic changes in the tibial region, such as cupping of the medial tibial plateau and tibial physis collapse. While discoid medial meniscal tears with hypoplasia of the femoral medial condyles have not been previously reported. Herein, we report a case of bilateral discoid medial menisci associated with meniscal tears and femoral bone changes...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29130880/two-patients-and-two-knee-cysts
#18
Hale Ersoy, Stephen J Pomeranz
Differential diagnosis of a cystic lesion adjacent to menisci can be a challenge even when the case presents as seemingly straightforward. To "tell the story" as accurately as possible, the radiologist must be familiar with the natural history of these lesions as well as distinctive imaging features and must take all relevant factors into consideration, such as patient's age, activity level, and surgical history. This article presents two cases to illustrate how imaging features affect the report and management plan...
October 2017: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29106743/quantifying-meniscal-kinematics-in-dogs
#19
Brian H Park, Scott A Banks, Antonio Pozzi
The dog has been used extensively as an experimental model to study meniscal treatments such as meniscectomy, meniscal repair, transplantation and regeneration. However, there is very little information on meniscal kinematics in the dog. This study used MR imaging to quantify in vitro meniscal kinematics in loaded dog knees in four distinct poses: extension, flexion, internal and external rotation. A new method was used to track the meniscal poses along the convex and posteriorly tilted tibial plateau. Meniscal displacements were large, displacing 13...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29103976/accelerating-knee-mr-imaging-compressed-sensing-in-isotropic-three-dimensional-fast-spin-echo-sequence
#20
Seung Hyun Lee, Young Han Lee, Jin-Suck Suh
PURPOSE: To compare image quality between compressed sensing (CS)-3D-fast spin-echo (FSE) and conventional 3D-FSE sequences for knee magnetic resonance imaging (MRI). METHODS: Knee MRI of 43 patients (male:female, 14:29; mean age, 53years) were acquired using conventional and CS-3D-FSE with an acceleration factor of 1.5. Overall image quality was assessed by correlation coefficient, root-mean-square error (RMSE), and structural similarity (SSIM) index. Regional image quality was evaluated using signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs)...
November 15, 2017: Magnetic Resonance Imaging
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