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https://www.readbyqxmd.com/read/28318650/the-distribution-of-vascular-endothelial-growth-factor-in-human-meniscus-and-a-meniscal-injury-model
#1
Zhichao Lu, Takayuki Furumatsu, Masataka Fujii, Ami Maehara, Toshifumi Ozaki
BACKGROUND: The meniscus plays an important role in controlling the complex biomechanics of the knee. Meniscus injury is common in the knee joint. The perimeniscal capillary plexus supplies the outer meniscus, whereas the inner meniscus is composed of avascular tissue. Angiogenesis factors, such as vascular endothelial growth factor (VEGF), have important roles in promoting vascularization of various tissues. VEGF-mediated neovascularization is beneficial to the healing of injured tissues...
March 15, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28302318/regional-differences-of-tibial-and-femoral-cartilage-in-the-chondrocyte-gene-expression-immunhistochemistry-and-composite-in-different-stages-of-osteoarthritis
#2
A Lahm, D Dabravolski, H Spank, H Merk, J Esser, R Kasch
The function of articular cartilage as an avascular tissue is mainly served by collagen type II and proteoglycan molecules. Within this matrix homeostasis between production and breakdown of the matrix is exceptionally sensitive. The current study was conducted to identify regional differences in specific alterations in cartilage composition during the osteoarthritic process of the human knee joint. Therefor the changes in the expression of the key molecules of the extracellular matrix were measured in dependence of the anatomical side (femoral vs tibial) and associated with immunohistochemistry and quantitative measurement...
February 24, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28301221/diagnosis-of-internal-derangement-of-the-knee-volume-isotropic-turbo-spin-echo-acquisition-mri-with-fat-suppression-versus-without-fat-suppression
#3
Ji Hyun Lee, Young Cheol Yoon, Ki Jeong Park, Joon Ho Wang
OBJECTIVE: The purpose of this study was to compare 3D volume isotropic turbo spin-echo acquisition (VISTA) MRI with and without fat suppression for use in evaluating ligaments, menisci, and cartilage. MATERIALS AND METHODS: Two radiologists retrospectively and independently reviewed 71 MRI studies. Each study consisted of 3D intermediate-weighted VISTA images with fat suppression and without fat suppression. The presence of tears of the anterior cruciate and posterior cruciate ligaments, tears of the medial and lateral menisci, and cartilaginous defects was evaluated...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28282214/clinical-and-radiographic-outcomes-of-meniscus-surgery-and-future-targets-for-biologic-intervention-a-review-of-data-from-the-moon-group
#4
Robert W Westermann, Morgan Jones, David Wasserstein, Kurt P Spindler
Meniscus injury and treatment occurred with the majority of anterior cruciate ligament reconstructions (ACLR) in the multicenter orthopaedic outcomes (MOON) cohort. We describe the patient reported outcomes, radiographic outcomes and predictors of pain from meniscus injuries and treatment in the setting of ACLR. Patient reported outcomes improve significantly following meniscus repair with ACLR, but differences exist based on the meniscus injury laterally (medial or lateral). Patients undergoing medial meniscus repair have worse patient-reported outcomes and more pain compared to those with uninjured menisci...
March 10, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28267400/current-concepts-on-structure-function-relationships-in-the-menisci
#5
S H J Andrews, A B Adesida, Ziad Abusara, N G Shrive
We review current thinking about the structure and function of the menisci and introduce new data about their tibial and femoral surfaces. We show from the literature that the menisci are intricately organized structures that perform many tasks in the knee. As the femur and tibia approach each other when the knee is bearing load, circumferential tension develops in the menisci, enabling the transmission of compressive load between the femoral and tibial cartilage layers. A low shear modulus is necessary for the tissue to adapt its shape to the changing radius of the femur as that bone moves relative to the tibia during joint articulation...
March 7, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28231647/outcome-of-acl-reconstruction-for-chronic-acl-injury-in-knees-without-the-posterior-horn-of-the-medial-meniscus-comparison-with-acl-reconstructed-knees-with-an-intact-medial-meniscus
#6
Kevin Syam, Devendra K Chouhan, Mandeep Singh Dhillon
Purpose: Cadaveric studies have shown that deficiency of the posterior horn of the medial meniscus (PHMM) increases strain on the anterior cruciate ligament (ACL) graft. However, its influence on the clinical and radiological outcome after ACL reconstruction is less discussed and hence evaluated in this study. Materials and Methods: This study included 77 cases of ACL reconstruction with a minimum 18-month follow-up. Of the 77 cases, 41 patients with intact menisci were compared clinically and radiologically with 36 patients with an injury to the PHMM that required various grades of meniscectomy...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28229984/anatomical-knee-variants-in-discoid-lateral-meniscal-tears
#7
Xu-Xu Chen, Jian Li, Tao Wang, Yang Zhao, Hui Kang
BACKGROUND: Discoid lateral meniscus was a common meniscal dysplasia and was predisposed to tear. There were some anatomical knee variants in patients with discoid lateral meniscus. The aim of this study was to analyze the relationship between anatomical knee variants and discoid lateral meniscal tears. METHODS: There were totally 125 cases of discoid lateral meniscus enrolled in this study from February 2008 to December 2013. Eighty-seven patients who underwent arthroscopic surgery for right torn discoid lateral meniscus were enrolled in the torn group...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28224064/anterior-horn-meniscal-repair-using-an-outside-in-suture-technique
#8
Travis J Menge, Chase S Dean, Jorge Chahla, Justin J Mitchell, Robert F LaPrade
The menisci are important structures within the knee that play a critical role in maintaining proper stability, load distribution, and joint lubrication. Injury to the menisci has been found to significantly alter the complex biomechanics of the knee, and thus affect the health and longevity of the native joint. Tears involving the anterior horn are increasingly recognized as an important pathology. Although early treatment of meniscal tears focused primarily on removal of the injured tissue, recent attention on the long-term consequences of partial or total meniscectomy has led to increased attempts at meniscus repair whenever possible...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28214478/accuracy-of-64-section-mdct-in-the-diagnosis-of-cruciate-ligament-tears
#9
E J Heffernan, D E Moran, J F Gerstenmaier, C J McCarthy, C Hegarty, C J McMahon
AIM: To evaluate the accuracy of non-arthrographic 64-section multidetector computed tomography (CT) in the assessment of cruciate ligament tears. A secondary goal was to determine its accuracy in the diagnosis of additional soft-tissue injuries around the knee. MATERIALS AND METHODS: Forty consecutive outpatients underwent same-day magnetic resonance imaging (MRI) and 64-slice multidetector CT (MDCT) of the knee in this prospective study. MDCT images were independently evaluated for integrity of the anterior (ACL) and posterior cruciate ligaments (PCL), medial and lateral menisci, and medial and lateral collateral ligaments...
February 15, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28213703/proximal-tibial-bony-and-meniscal-slopes-are-higher-in-acl-injured-subjects-than-controls-a-comparative-mri-study
#10
Ashraf Elmansori, Timothy Lording, Raphaël Dumas, Khalifa Elmajri, Philippe Neyret, Sébastien Lustig
PURPOSE: Increased tibial slope is reported as a risk factor of non-contact anterior cruciate ligament (ACL) injury, but the effect of the soft tissues on slope remains unclear. The primary aims of this study were to compare the tibial bony and soft tissue slopes between patients with and without ACL injury, and to investigate the relationship between the meniscal slopes (MS) and the tibial bony slope. Our hypothesis was that the menisci would correct the inclination of the bony tibial slope towards the horizontal...
February 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28211591/magnetic-resonance-imaging-of-the-knee-an-overview-and-update-of-conventional-and-state-of-the-art-imaging
#11
Nicholas C Nacey, Matthew G Geeslin, Grady Wilson Miller, Jennifer L Pierce
Magnetic resonance imaging (MRI) has become the preferred modality for imaging the knee to show pathology and guide patient management and treatment. The knee is one of the most frequently injured joints, and knee pain is a pervasive difficulty that can affect all age groups. Due to the diverse pathology, complex anatomy, and a myriad of injury mechanisms of the knee, the MRI knee protocol and sequences should ensure detection of both soft tissue and osseous structures in detail and with accuracy. The knowledge of knee anatomy and the normal or injured MRI appearance of these key structures are critical for precise diagnosis...
February 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28203586/comparison-of-kinematics-and-tibiofemoral-contact-pressures-for-native-and-transplanted-lateral-menisci
#12
Patrick C McCulloch, Donald Dolce, Hugh L Jones, Andrea Gale, Michael G Hogen, Jason Alder, Jeremiah E Palmer, Philip C Noble
BACKGROUND: Lateral meniscus transplantation is a proven treatment option for the meniscus-deficient knee, yet little is known about meniscal kinematics, strain, and tibiofemoral contact pressure changes after transplantation or the effect of altered root position in lateral meniscus transplantation. PURPOSE: To compare the native lateral meniscal kinematics, strain, and tibiofemoral contact pressures to a best-case scenario meniscus transplant with perfectly matched size and position and to determine how sensitive these factors are to subtle changes in shape and position by using a nonanatomic meniscus transplant position...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203112/bone-contusion-progression-from-traumatic-knee-injury-association-of-rate-of-contusion-resolution-with-injury-severity
#13
Douglas R Pedersen, Georges Y El-Khoury, Dan R Thedens, Mothana Saad-Eldine, Phinit Phisitkul, Annunziato Amendola
BACKGROUND: Bone contusions are frequently encountered in magnetic resonance imaging (MRI) evaluation of knee anterior cruciate ligament (ACL) injuries. Their role as indicators of injury severity remains unclear, primarily due to indeterminate levels of joint injury forces and to a lack of preinjury imaging. PURPOSE: The purpose of this study was to 1) quantify bone contusion pathogenesis following traumatic joint injuries using fixed imaging follow-ups, and 2) assess the feasibility of using longitudinal bone contusion volumes as an indicator of knee injury severity...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/28186817/velocity-field-in-a-vertical-foam-film
#14
Jacopo Seiwert, Ronan Kervil, Soniraks Nou, Isabelle Cantat
The drainage of vertical foam films governs their lifetime. For a foam film supported on a rectangular solid frame, when the interface presents a low resistance to shear, the drainage dynamics involves a complex flow pattern at the film scale, leading to a drainage time proportional to the frame width. Using an original velocimetry technique, based on fluorescent foam films and photobleaching, we measure the horizontal and vertical components of the velocity in a draining film, thus providing the first quantitative experimental evidence of this flow pattern...
January 27, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28165810/the-origin-and-distribution-of-cd68-cd163-and-%C3%AE-sma-cells-in-the-early-phase-after-meniscal-resection-in-a-parabiotic-rat-model
#15
Shozaburo Terai, Yusuke Hashimoto, Kumi Orita, Shinya Yamasaki, Junsei Takigami, Takafumi Shinkuma, Takanori Teraoka, Yohei Nishida, Masafumi Takahashi, Hiroaki Nakamura
We previously reported that circulating peripheral blood-borne cells (PBCs) contribute to early-phase meniscal reparative change. Because macrophages and myofibroblasts are important contributors of tissue regeneration, we examined their origin and distribution in the reparative meniscus. Reparative menisci were evaluated at 1, 2, and 4 weeks post-meniscectomy by immunohistochemistry to locate monocytes and macrophages (stained positive for CD68 and CD163), and myofibroblasts (stained positive for αSMA). Of the total number of cells, 13% were CD68(+) at 1 week post-meniscectomy, which decreased to 1% by 4 weeks post-meniscectomy; of these, almost half of CD68(+) cells (49...
February 6, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28164061/arthroscopic-meniscectomy-and-meniscoplasty-for-a-torn-discoid-medial-meniscus-case-report-surgical-technique-and-literature-review
#16
Gokhale Nikhil Abhay, Samant Ashwin, Shahane Sunil, Kapopara Hardik
INTRODUCTION: Normal menisci of the knee are semilunar structures. Sometimes, a meniscus may be found to be thickened and disc like and is called a discoid meniscus. Such a discoid variant is usually found in the lateral meniscus. Its occurrence in the medial meniscus is extremely rare. CASE REPORT: We report a case of an 18-year-old female, who presented to us with knee pain and was found to have a discoid medial meniscus with a tear. We operated on her arthroscopically and performed meniscectomy and meniscoplasty...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28154426/a-new-experiment-for-investigating-evaporation-and-condensation-of-cryogenic-propellants
#17
K Bellur, E F Médici, M Kulshreshtha, V Konduru, D Tyrewala, A Tamilarasan, J McQuillen, J Leao, D S Hussey, D L Jacobson, J Scherschligt, J C Hermanson, C K Choi, J S Allen
Passive and active technologies have been used to control propellant boil-off, but the current state of understanding of cryogenic evaporation and condensation in microgravity is insufficient for designing large cryogenic depots critical to the long-term space exploration missions. One of the key factors limiting the ability to design such systems is the uncertainty in the accommodation coefficients (evaporation and condensation), which are inputs for kinetic modeling of phase change. A novel, combined experimental and computational approach is being used to determine the accommodation coefficients for liquid hydrogen and liquid methane...
March 2016: Cryogenics
https://www.readbyqxmd.com/read/28152576/evaluation-of-novel-biodegradable-three-armed-and-hyper-branched-tissue-adhesives-in-a-meniscus-explant-model
#18
A I Bochyńska, G Hannink, R Verhoeven, D W Grijpma, P Buma
Current treatment methods to repair meniscal tears do not bring fully satisfactory results. Tissue adhesives are considered promising alternatives, since they are easy to apply and cause minimal tissue trauma. The first aim of this study was to analyze the adhesive properties of and tissue response to two recently developed biodegradable block copolymeric three-armed- and hyper-branched tissue adhesives. The second aim was to investigate if tissue surface modification with collagenase improves the attachment of the adhesives and increases the healing potential of the tissue...
February 2, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28130031/comparison-between-intra-and-extra-articular-tension-of-the-graft-during-fixation-in-anterior-cruciate-ligament-reconstruction
#19
Yuichiro Nishizawa, Yuichi Hoshino, Kouki Nagamune, Daisuke Araki, Kanto Nagai, Masahiro Kurosaka, Ryosuke Kuroda
PURPOSE: To evaluate the tension deprivation through the tunnels with and without preconditioning at the time of fixation, and the influences of cyclic loading and pretensioning on graft tension in anatomic single bundle anterior cruciate ligament (ACL) reconstruction using a hamstring tendon. METHODS: Nine fresh-frozen cadaveric knees underwent anatomic ACL reconstruction using hamstring grafts. Each specimen was examined to ensure that there was no severe osteoarthritic change, ligament insufficiency, or torn menisci by manual and arthroscopic evaluation...
January 24, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28121190/the-biology-of-meniscal-pathology-in-osteoarthritis-and-its-contribution-to-joint-disease-beyond-simple-mechanics
#20
James Melrose, Emily S Fuller, Christopher B Little
The meniscal cartilages in the knee function to improve congruity of the medial and lateral femoro-tibial joints, and play critical roles in load distribution and joint stability. Meniscal tears of various configurations are one of the most common conditions of the knee, and are associated with an increased risk of developing osteoarthritis (OA). While this risk has been largely attributed to loss of the biomechanical functions of the menisci, there is accumulating evidence suggesting that other aspects of meniscal biology may play a role in determining the long-term consequences of meniscal damage for joint health...
January 25, 2017: Connective Tissue Research
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