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total gastrectomy gastric cancer

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https://www.readbyqxmd.com/read/29341148/outcomes-after-prophylactic-gastrectomy-for-hereditary-diffuse-gastric-cancer
#1
R T van der Kaaij, J P van Kessel, J M van Dieren, P Snaebjornsson, O Balagué, F van Coevorden, L E van der Kolk, K Sikorska, A Cats, J W van Sandick
BACKGROUND: Patients with hereditary diffuse gastric cancer and a CDH1 mutation have a 60-80 per cent lifetime risk of developing diffuse gastric cancer. Total prophylactic gastrectomy eliminates this risk, but is associated with considerable morbidity. The effectiveness (removal of all gastric mucosa) and outcomes of this procedure were evaluated retrospectively. METHODS: All consecutive individuals undergoing a prophylactic gastrectomy for a CDH1 mutation or gastric signet ring cell foci at the authors' institute between 2005 and 2017 were included...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29340922/prevention-of-internal-hernia-during-robotic-total-gastrectomy-for-gastric-cancer
#2
Toshiyasu Ojima, Masaki Nakamura, Mikihito Nakamori, Keiji Hayata, Masahiro Katsuda, Toshiaki Tsuji, Shimpei Maruoka, Hiroki Yamaue
BACKGROUND: Postoperative internal hernia (IH) is a potentially life-threatening acute protrusion of viscus through an iatrogenic mesenteric defect. In our retrospective study of 1943 consecutive gastric cancer (GC) patients who had undergone surgery, the incidence of IH after laparoscopic total gastrectomy (LTG) was 4.9%.1 This high incidence seems to be caused by decreased adhesion formation after LTG. There is no consensus regarding orifice management during robotic total gastrectomy (RTG)...
January 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29338698/enteral-immunonutrition-versus-enteral-nutrition-for-gastric-cancer-patients-undergoing-a-total-gastrectomy-a-systematic-review-and-meta-analysis
#3
Ying Cheng, Junfeng Zhang, Liwei Zhang, Juan Wu, Zhen Zhan
BACKGROUND: Nutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. This meta-analysis aimed to assess the impact of EIN for patients with GC on biochemical, immune indices and clinical outcomes...
January 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29331883/curative-distal-pancreatectomy-in-patients-with-acinar-cell-carcinoma-of-pancreas-diagnosed-by-endoscopic-aspiration-via-esophago-jejunostomy-a-successful-case-report
#4
Takeomi Hamada, Atsushi Nanashima, Masahide Hiyoshi, Makoto Ikenoue, Naoya Imamura, Koichi Yano, Yoshiro Fujii, Yoshimasa Kubota, Tesshin Ban, Hiroshi Kawakami, Yuichiro Sato
INTRODUCTION: This is a case report on the advances in preoperative endoscopic-guided fine-needle-aspiration (FNA) diagnosis for pancreatic carcinoma to achieve a curative operation even in patients who have a history of total gastrectomy. CASE PRESENTATION: A 65-year-old man, who underwent total gastrectomy for gastric cancer 13 years ago, had discomfort in the left lateral abdomen. A 3-cm hypovascular mass accompanying a large distal pseudocyst in the pancreatic tail was observed on computed tomography...
January 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29330531/low-density-neutrophils-ldn-in-postoperative-abdominal-cavity-assist-the-peritoneal-recurrence-through-the-production-of-neutrophil-extracellular-traps-nets
#5
Rihito Kanamaru, Hideyuki Ohzawa, Hideyo Miyato, Shiro Matsumoto, Hidenori Haruta, Kentaro Kurashina, Shin Saito, Yoshinori Hosoya, Hironori Yamaguchi, Hiroharu Yamashita, Yasuyuki Seto, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
Many types of immune cells appear in peritoneal cavity after abdominal surgery. In patients who underwent laparotomy due to gastric cancer, peritoneal lavages were obtained before and after surgical procedure. Cells were recovered from intermediate layer after Ficoll-Hypaque centrifugation and analyzed for phenotypes and functions, especially focused on low density neutrophils (LDN). The number of CD66b (+) LDN with mature phenotype was markedly elevated in postoperative as compared with preoperative lavages...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310358/a-systematic-review-and-meta-analysis-of-robot-assisted-versus-laparoscopically-assisted-gastrectomy-for-gastric-cancer
#6
Yi Wang, Xudong Zhao, Yanjing Song, Aizhen Cai, Hongqing Xi, Lin Chen
BACKGROUND: Robotic-assisted gastrectomy (RAG) has been used for gastric cancer since 2002. This meta-analysis was carried out to evaluate whether RAG is safer and more effective than conventional laparoscopically assisted gastrectomy (LAG) for gastric cancer. METHODS: We performed a manual search for these 2 types of operations (RAG and LAG) in the PubMed, Embase, and the Cochrane Library databases up to April 30, 2016. Twelve nonrandomized controlled trials that reported on RAG and LAG for gastric cancer were included...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29302921/isolated-breast-metastasis-from-gastric-cancer-in-a-male-patient
#7
Hirokazu Kubo, Tetsuya Shimizu, Hitoshi Sekido, Goro Matsuda, Kazuhisa Takeda, Akira Watanabe, Risa Sakamoto, Yuji Yamamoto, Junya Toyoda, Hitoshi Niino
A 72-year-old man underwent total gastrectomy for gastric cancer (por2, T3, N2, Stage IIIA). Eleven courses of postoperative chemotherapy with TS-1 (tegafur/gimeracil/oteracil) were administered. Five months after surgery, the serum carcinoembryonic antigen value was slightly elevated. However, computed tomography did not reveal any metastatic lesions in other organs. Two years after surgery, the patient felt a mass in the left mammary. A 2-cm tumor was palpable in the central portion of the breast. Ultrasonography revealed a hypoechoic tumor, which was Class 3 on aspiration biopsy cytological examination...
January 4, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29302375/laparoscopic-reinforcement-suture-lars-on-staple-line-of-duodenal-stump-using-barbed-suture-in-laparoscopic-gastrectomy-for-gastric-cancer-a-prospective-single-arm-phase-ii-study
#8
Min Chan Kim, Sang Yun Kim, Kwan Woo Kim
Purpose: Laparoscopic gastrectomy is accepted as a standard treatment for patients with early gastric cancer in Korea, Japan, and China. However, duodenal stump leakage remains a fatal complication after gastrectomy. We conducted a prospective phase II study to evaluate the safety of the new technique of laparoscopic reinforcement suture (LARS) on the duodenal stump. Materials and Methods: The estimated number of patients required for this study was 100 for a period of 18 months...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29302373/risk-factors-of-microscopic-invasion-in-early-gastric-cancer
#9
Jong-Ho Choi, Yun-Suhk Suh, Shin-Hoo Park, Seong-Ho Kong, Hyuk-Joon Lee, Woo Ho Kim, Han-Kwang Yang
Purpose: This study aimed to evaluate the clinical significance of microscopic invasion to determine the adequate resection margin in early gastric cancer (EGC). Materials and Methods: A retrospective review was performed that included patients who underwent gastrectomy for clinical early gastric cancer (cEGC) at Seoul National University Hospital between January 2007 and December 2010. After subtracting the microscopic resection margin from the gross resection margin for each proximal or distal resection margin, microscopic invasion was represented by the larger value...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29299363/does-histology-really-influence-gastric-cancer-prognosis
#10
Carrie Luu, Ram Thapa, Katherine Woo, Domenico Coppola, Khaldoun Almhanna, Jose M Pimiento, Dung-Tsa Chen, Daissy Dominguez Marquez, Pamela J Hodul
Background: Gastric cancer (GC) is associated with poor survival despite curative-intent surgical resection and systemic therapy. Our objective is to examine the impact of histology on prognosis as well as the impact of linitis plastica (LP) on survival. Methods: The GC database at a single institution was evaluated for patients who underwent resection from 2000 to 2015. Clinicopathologic characteristics were examined and descriptive statistics was used to analyze four groups of patients based on Lauren classification: intestinal (n=93), diffuse (n=20), diffuse with signet-ring cell features (n=57), and LP (n=40)...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29290772/adjuvant-chemotherapy-improves-survival-in-stage-iii-gastric-cancer-after-d2-surgery
#11
Shin-Chun Chang, Keng-Hao Liu, Chia-Yen Hung, Chun-Yi Tsai, Jun-Te Hsu, Ta-Sen Yeh, Jen-Shi Chen, Yung-Chia Kuo, Yu-Shin Hung, Wen-Chi Chou
Background: Stage III gastric cancer is characterized by locally advanced disease with varying anatomic extent as measured by the 7th edition of the American Joint Committee on Cancer (AJCC) staging system. There are no prognostic factors specifically identified in patients with stage III gastric cancer following extended lymph node dissection (D2) surgery. Materials and Methods: From 2007 to 2014, 534 patients with stage III gastric cancer underwent radical gastrectomy and D2 dissection at the Chang Gung Memorial Hospital...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29288114/efficacy-of-fast-track-surgery-in-laparoscopic-radical-gastrectomy-for-gastric-cancer-a-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Qing Liu, Li Ding, Honglei Jiang, Chundong Zhang, Junzhe Jin
OBJECTIVE: To conduct a systematic review of efficacy and security of fast track surgery (FTS) in laparoscopic radical gastrectomy for gastric cancer. METHODS: We searched PubMed, Embase, and Cochrane Library Databases and supplemented by other searches to collect randomized controlled trials (RCTs) on the comparison of fast track surgery combined with laparoscopy versus laparoscopy separately used in radical gastrectomy for gastric cancer before December 2016. After screening for inclusion, data extraction, and quality assessment, meta-analysis was conducted by the Review Manager 5...
December 26, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29282515/impact-of-the-weekday-of-surgery-on-outcome-in-gastric-cancer-patients-who-underwent-d2-gastrectomy
#13
Felix Berlth, K Messerle, P S Plum, S-H Chon, J von Ambüren, A Hohn, M Dübbers, C J Bruns, S P Mönig, E Bollschweiler, A H Hölscher, H Alakus
BACKGROUND: The impact of the weekday of surgery in major elective cases of the upper-GI has been discussed controversially. The objective of this study was to assess whether weekday of surgery influences outcome in patients undergoing D2-gastrectomy. MATERIALS AND METHODS: Patients who underwent D2-gastrectomy for gastric adenocarcinoma between 1996 and 2016 were included. Weekday of surgery was recognized, and subgroups were analyzed regarding clinical and histopathological differences...
December 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29280035/lymphovascular-invasion-and-lymph-node-metastasis-rates-in-papillary-adenocarcinoma-of-the-stomach-implications-for-endoscopic-resection
#14
Byung-Hoon Min, Sun-Ju Byeon, Jun Haeng Lee, Kyoung-Mee Kim, Ji Yeong An, Min Gew Choi, Jun Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim
BACKGROUND: Current Japanese gastric cancer treatment guidelines recommend the same endoscopic resection criteria for papillary early gastric cancer (EGC) and well-differentiated (WD) or moderately differentiated (MD) EGC. To evaluate the appropriateness of this recommendation, we compared the clinicopathological characteristics of papillary EGC with those of WD, MD, poorly differentiated (PD), and signet ring cell (SRC) EGC. METHODS: A total of 6710 patients who underwent radical gastrectomy for EGC were included...
December 26, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29279692/long-term-survival-of-a-patient-with-adenocarcinoma-of-the-esophagogastric-junction-with-a-portal-vein-tumor-thrombosis-who-underwent-palliative-total-gastrectomy-a-case-report
#15
Sung Don Oh, Sung Jin Oh, Byoung Jo Suh, Jin Yong Shin, Jong Kwon Park
Portal vein tumor thrombosis (PVTT) with advanced gastric cancer is very rare; when it occurs, it exhibits aggressive growth and carries a poor prognosis. In addition, definitive treatment has not been established due to insufficient data. Herein, we report a case of PVTT associated with an adenocarcinoma of the esophagogastric junction that was successfully controlled by means of a palliative total gastrectomy without surgical resection of the PVTT and administration of palliative continuous doxifluridine.
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29260338/a-case-of-ramucirumab-related-gastrointestinal-perforation-in-gastric-cancer-with-small-bowel-metastasis
#16
Shinya Urakawa, Daisuke Sakai, Yasuhiro Miyazaki, Toshihiro Kudo, Aya Katou, Chiaki Inagaki, Koji Tanaka, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Taroh Satoh, Masaki Mori, Yuichiro Doki
BACKGROUND: Ramucirumab is a monoclonal antibody targeting vascular endothelial growth factor receptor 2 (VEGFR-2). Ramucirumab either alone or in combination with paclitaxel (PTX) has been found to be safe and effective for patients with previously treated advanced gastric cancer. One of the serious adverse events associated with ramucirumab is gastrointestinal (GI) perforation. CASE PRESENTATION: We report the case of a 67-year-old man who developed a ramucirumab-related GI perforation while undergoing treatment for gastric cancer with small bowel metastasis...
December 19, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29250509/laparoscopic-reinforcement-suture-on-staple-line-of-duodenal-stump-using-barbed-suture-during-laparoscopic-gastrectomy-for-gastric-cancer
#17
Sang Yun Kim, So Hyun Nam, Jae Seok Min, Min Chan Kim
Purpose: Duodenal stump fistula (DSF) is a serious complication after gastrectomy for gastric cancer. Although risk evaluation and management of DSF were presented by some investigators, there was no technical attempt has been made to prevent DSF during laparoscopic gastrectomy until now. Methods: Consecutive 99 patients were enrolled from April 2014 to February 2016 in 2 institutes. All patients were performed laparoscopic gastrectomy for gastric cancer. After cutting of duodenal stump, laparoscopic reinforcement suture (LARS) commenced with continuous invagination method or interrupted method by barbed suture...
December 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29245951/construction-of-a-model-predicting-the-risk-of-tube-feeding-intolerance-after-gastrectomy-for-gastric-cancer-based-on-225-cases-from-a-single-chinese-center
#18
Wu Xiaoyong, Li Xuzhao, Yu Deliang, Yu Pengfei, Hang Zhenning, Bai Bin, Li Zhengyan, Pang Fangning, Wang Shiqi, Zhao Qingchuan
Identifying patients at high risk of tube feeding intolerance (TFI) after gastric cancer surgery may prevent the occurrence of TFI; however, a predictive model is lacking. We therefore analyzed the incidence of TFI and its associated risk factors after gastric cancer surgery in 225 gastric cancer patients divided into without-TFI (n = 114) and with-TFI (n = 111) groups. A total of 49.3% of patients experienced TFI after gastric cancer. Multivariate analysis identified a history of functional constipation (FC), a preoperative American Society of Anesthesiologists (ASA) score of III, a high pain score at 6-hour postoperation, and a high white blood cell (WBC) count on the first day after surgery as independent risk factors for TFI...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29234941/short-term-surgical-outcomes-of-a-randomized-controlled-trial-comparing-laparoscopic-versus-open-gastrectomy-with-d2-lymph-node-dissection-for-advanced-gastric-cancer
#19
Yan Shi, Xianhui Xu, Yongliang Zhao, Feng Qian, Bo Tang, Yingxue Hao, Huaxing Luo, Jun Chen, Peiwu Yu
BACKGROUND: Laparoscopy-assisted gastrectomy (LAG) has gained acceptance as one of the best treatments for early gastric cancer. However, the application of LAG with D2 lymph node dissection in patients with locally advanced gastric cancer (AGC) remains controversial. METHODS: We launched a prospective randomized controlled trial comparing laparoscopic and open gastrectomy with D2 lymph node dissection for locally AGC to evaluate technical safety and oncologic feasibility...
December 12, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29230588/the-impact-of-advanced-age-on-short-term-outcomes-following-gastric-cancer-resection-an-acs-nsqip-analysis
#20
Trevor D Hamilton, Alyson L Mahar, Barbara Haas, Kaitlyn Beyfuss, Calvin H L Law, Paul J Karanicolas, Natalie G Coburn, Julie Hallet
BACKGROUND: Evidence on short-term outcomes for GC resection in elderly patients is limited by small samples from single-institutions. This study sought to examine the association between advanced age and short-term outcomes of gastrectomy for gastric cancer (GC). METHODS: Using ACS-NSQIP data, patients undergoing gastrectomy for GC (2007-2013) were identified. Primary outcome was 30-day major morbidity. Outcomes were compared across age categories (<65, 65-70, 71-75, 76-80, >80 years old)...
December 11, 2017: Gastric Cancer
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