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https://www.readbyqxmd.com/read/29771724/early-impact-of-medicare-accountable-care-organizations-on-inpatient-surgical-spending
#1
Hari Nathan, Jyothi R Thumma, Andrew M Ryan, Justin B Dimick
OBJECTIVE: To evaluate whether hospital participation in accountable care organizations (ACOs) is associated with reduced Medicare spending for inpatient surgery. BACKGROUND: ACOs have proliferated rapidly and now cover more than 32 million Americans. Medicare Shared Savings Program (MSSP) ACOs have shown modest success in reducing medical spending. Whether they have reduced surgical spending remains unknown. METHODS: We used 100% Medicare claims from 2010 to 2014 for patients aged 65 to 99 years undergoing 6 common elective surgical procedures [abdominal aortic aneurysm (AAA) repair, colectomy, coronary artery bypass grafting (CABG), hip or knee replacement, or lung resection]...
May 16, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29768311/impact-of-provider-participation-in-aco-programs-on-preventive-care-services-patient-experiences-and-health-care-expenditures-in-us-adults-aged-18-64
#2
Young-Rock Hong, Kalyani Sonawane, Samantha Larson, Arch G Mainous, Nicole M Marlow
BACKGROUND: Little is known about the impact of accountable care organization (ACO) on US adults aged 18-64. OBJECTIVES: To examine whether having a usual source of care (USC) provider participating in an ACO affects receipt of preventive care services, patient experiences, and health care expenditures among nonelderly Americans. RESEARCH DESIGN: A cross-sectional analysis of the 2015 Medical Organizations Survey linked with the Medical Expenditure Panel Survey...
May 15, 2018: Medical Care
https://www.readbyqxmd.com/read/29767222/mortality-in-asthma-chronic-obstructive-pulmonary-disease-overlap-in-the-united-states
#3
Suchit Kumbhare, Charlie Strange
OBJECTIVES: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is recognized increasingly as a distinct clinical entity and is associated with higher comorbidities compared with patients with asthma and COPD alone. Little is known about the leading causes of death related to ACO in the US general population, however. Our aim was to define the causes of mortality among patients with ACO compared with asthma and COPD in the US population. METHODS: We examined questions using the National Health and Nutrition Examination Survey III database linked to the National Death Index...
May 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29763768/effects-on-estrogen-dependent-and-triple-negative-breast-cancer-cells-growth-of-ni-ii-zn-ii-and-cd-ii-complexes-with-the-schiff-base-derived-from-pyridine-2-carboxaldehyde-and-5-6-diamino-1-3-dimethyluracil-explored-through-the-renin-angiotensin-system-ras
#4
Nuria A Illán-Cabeza, Sonia B Jiménez-Pulido, Francisco Hueso-Ureña, María J Ramírez-Expósito, Purificación Sánchez-Sánchez, José M Martínez-Martos, Miguel N Moreno-Carretero
A series of Ni(II), Zn(II) and Cd(II) complexes with the Schiff base derived from the condensation 1:1 from pyridine-2-carboxaldehyde and 5,6-diamino-1,3-dimethyluracil (6-amino-1,3-dimethyl-5-[(pyridin-2-ylmethylidene)-amino]pyrimidine-2,4(1H,3H)-dione, DAAUPic) were synthesized and subsequently characterized by means of elemental analysis, FT-IR, NMR and nine of them by X-ray diffraction. Except the [Zn(μ-O,O'-AcO)(N5 ,N6 ,N1F -DAAUPicH-1 )]2 and [Cd(O,O'-NO3 )(μ-O4 ,(N5 ,N6 ,N1F )-DAAUPicH-1 )(H2 O)]2 ·2H2 O dimers and the [Cd(μ-S,N-SCN)(N5 ,N6 ,N1F -DAAUPicH-1 )]n chain-like polymer, all of them display monomeric molecular structures...
May 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29762273/patient-engagement-in-aco-practices-and-patient-reported-outcomes-among-adults-with-co-occurring-chronic-disease-and-mental-health-conditions
#5
Susan L Ivey, Stephen M Shortell, Hector P Rodriguez, Yue Emily Wang
BACKGROUND: Accountable care organizations (ACOs) have increased their use of patient activation and engagement strategies, but it is unknown whether they achieve better outcomes for patients with comorbid chronic physical and mental health conditions. OBJECTIVES: To assess the extent to which practices with patient-centered cultures, greater shared decision-making strategies, and better coordination among team members have better patient-reported outcomes (PROs) for patients with diabetes and/or cardiovascular and comorbid mental health diagnoses...
May 12, 2018: Medical Care
https://www.readbyqxmd.com/read/29754074/structure-activity-relationship-of-new-antimalarial-1-aryl-3-susbtituted-propanol-derivatives-synthesis-preliminary-toxicity-profiling-parasite-life-cycle-stage-studies-target-exploration-and-targeted-delivery
#6
Miguel Quiliano, Adriana Pabón, Ernest Moles, Leonardo Bonilla-Ramirez, Isabelle Fabing, Kim Y Fong, Diego A Nieto-Aco, David W Wright, Juan C Pizarro, Ariane Vettorazzi, Adela López de Cerain, Eric Deharo, Xavier Fernández-Busquets, Giovanny Garavito, Ignacio Aldana, Silvia Galiano
Design, synthesis, structure-activity relationship, cytotoxicity studies, in silico drug-likeness, genotoxicity screening, and in vivo studies of new 1-aryl-3-substituted propanol derivatives led to the identification of nine compounds with promising in vitro (55, 56, 61, 64, 66, and 70-73) and in vivo (66 and 72) antimalarial profiles against Plasmodium falciparum and Plasmodium berghei. Compounds 55, 56, 61, 64, 66 and 70-73 exhibited potent antiplasmodial activity against chloroquine-resistant strain FCR-3 (IC50 s < 0...
April 24, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29750029/mortality-in-copd-patients-according-to-clinical-phenotypes
#7
Rafael Golpe, María Suárez-Valor, Irene Martín-Robles, Pilar Sanjuán-López, Esteban Cano-Jiménez, Olalla Castro-Añón, Luis A Pérez de Llano
Purpose: Grouping COPD subjects into clinical phenotypes might be useful for the management of the disease, but the clinical implications of such classification are still not totally clear, especially regarding prognosis. The primary objective of this study was to assess whether the mortality rates were different between four predefined clinical phenotypes. Patients and methods: This is a retrospective, observational study carried out at the COPD clinic of a University Hospital...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29749288/changes-in-quality-of-life-among-enrollees-in-hennepin-health-a-medicaid-expansion-aco
#8
Katherine D Vickery, Nathan D Shippee, Laura M Guzman-Corrales, Cindy Cain, Sarah Turcotte Manser, Tom Walton, Jessica Richards, Mark Linzer
Despite limited program evaluations of Medicaid accountable care organizations (ACOs), no studies have examined if cost-saving goals negatively affect quality of life and health care experiences of low-income enrollees. The Hennepin Health ACO uses an integrated care model to address the physical, behavioral, and social needs of Medicaid expansion enrollees. As part of a larger evaluation, we conducted semistructured interviews with 35 primary care using Hennepin Health members enrolled for 2 or more years...
May 1, 2018: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29744809/identification-of-a-feature-selection-based-pattern-recognition-scheme-for-finger-movement-recognition-from-multichannel-emg-signals
#9
Geethanjali Purushothaman, Raunak Vikas
This paper focuses on identification of an effective pattern recognition scheme with the least number of time domain features for dexterous control of prosthetic hand to recognize the various finger movements from surface electromyogram (EMG) signals. Eight channels EMG from 8 able-bodied subjects for 15 individuals and combined finger activities have been considered in this work. In this work, an attempt has been made to recognize a number of classes with the least number of features. Therefore, EMG signals are pre-processed using dual tree complex wavelet transform to improve the discriminating capability of features and time domain features such as zero crossing, slope sign change, mean absolute value, and waveform length is extracted from the pre-processed data...
May 9, 2018: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29744514/a-newly-developed-highly-selective-zn-2-aco-ion-pair-sensor-through-partner-preference-equal-efficiency-under-solitary-and-colonial-situation
#10
Monaj Karar, Suvendu Paul, Bhaskar Biswas, Tapas Majumdar, Arabinda Mallick
Unusual self-sorting of an ion-pair under highly crowded conditions driven by a synthesized intelligent molecule 2-((E)-(3-((E)-2-hydroxy-3-methoxybenzylideneamino)-2-hydroxypropyl imino)methyl)-6-methoxyphenol, hereafter HBP, is described. When a mixture of various metal salts was allowed to react with HBP, only a specific ion-pair ZnII/AcO- in the solution simultaneously reacted, resulting in high-fidelity ion-pair recognition of HBP. This phenomenon was evidenced by significant changes in the absorption spectra and huge enhancement in emission intensity of HBP...
May 10, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29743925/-gynostemma-pentaphyllum-attenuates-the-progression-of-nonalcoholic-fatty-liver-disease-in-mice-a-biomedical-investigation-integrated-with-in-silico-assay
#11
Ming Hong, Zhe Cai, Lei Song, Yongqiang Liu, Qi Wang, Xiangfei Feng
Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease in developed countries. Oxidative stress plays a critical role in the progression of NAFLD. Modern pharmacological study and clinical trials have demonstrated the remarkable antioxidant activity of Gynostemma pentaphyllum (GP) in chronic liver disease. One aim of this study was to explore the potential protective effects and mechanisms of action of GP extract on NAFLD. The in vivo results showed that GP extract could alleviate fatty degeneration and haptic fibrosis in NAFLD mice...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29738276/psychosocial-risk-factors-and-asthma-among-adults-in-puerto-rico
#12
Yueh-Ying Han, Erick Forno, Glorisa Canino, Juan C Celedón
OBJECTIVE: Asthma and psychosocial stressors are common among Puerto Rican adults living in the United States. We estimated the prevalence of current asthma, and examined potential psychosocial risk factors and current asthma, among adults in Puerto Rico. METHODS: Cross-sectional study of 3,049 Puerto Ricans aged 18-64 years living in Puerto Rico between May 2014 and June 2016. A structured interview was conducted to obtain information on demographics, lifestyles, mental disorders, and respiratory health...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29737573/organizational-attributes-associated-with-medicare-aco-quality-performance
#13
Xi Zhu, Keith Mueller, Huang Huang, Fred Ullrich, Thomas Vaughn, A Clinton MacKinney
PURPOSE: To evaluate associations between geographic, structural, and service-provision attributes of Accountable Care Organizations (ACOs) participating in the Medicare Shared Savings Program (MSSP) and the ACOs' quality performance. METHODOLOGY: We conducted cross-sectional and longitudinal analyses of ACO quality performance using data from the Centers for Medicare and Medicaid Services and additional sources. The sample included 322 and 385 MSSP ACOs that had successfully reported quality measures in 2014 and 2015, respectively...
May 8, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29736282/biomaterial-influence-on-intraocular-lens-performance-an-overview
#14
REVIEW
Cari Pérez-Vives
There is strong evidence that the IOL material is the factor having the greatest impact on posterior capsule opacification (PCO), anterior capsule opacification (ACO) development, and glistening formation after cataract surgery, even though there are other IOL features-such as haptic material and design and edge and optic design-that also have some influence. We reviewed the published literature describing the adverse events that are mainly related to the intraocular lens (IOL) material, such as PCO, ACO, and the subsequent capsule contraction, as well as glistening formation...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29730652/resistin-regulates-fatty-acid-%C3%AE-oxidation-by-suppressing-expression-of-peroxisome-proliferator-activator-receptor-gamma-coactivator-1%C3%AE-pgc-1%C3%AE
#15
Fang He, Jie-Qiong Jin, Qing-Qing Qin, Yong-Qin Zheng, Ting-Ting Li, Yun Zhang, Jun-Dong He
BACKGROUND/AIMS: Abnormal fatty acid β oxidation has been associated with obesity and type 2 diabetes. Resistin is an adipokine that has been considered as a potential factor in obesity-mediated insulin resistance and type 2 diabetes. However, the effect of resistin on fatty acid β oxidation needs to be elucidated. METHODS: We detected the effects of resistin on the expression of fatty acid oxidation (FAO) transcriptional regulatory genes, the fatty acid transport gene, and mitochondrial β-oxidation genes using real-time PCR...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29724382/chronic-airway-obstruction-in-a-population-based-adult-asthma-cohort-prevalence-incidence-and-prognostic-factors
#16
Helena Backman, Sven-Arne Jansson, Caroline Stridsman, Hana Muellerova, Keele Wurst, Linnea Hedman, Anne Lindberg, Eva Rönmark
BACKGROUND: Asthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort. METHODS: During 1986-2001 a large population-based asthma cohort was identified (n = 2055, 19-72y). Subsamples have participated in clinical follow-ups during the subsequent years. The entire cohort was invited to a clinical follow-up including interview, spirometry, and blood sampling in 2012-2014 when n = 983 subjects performed adequate spirometry...
May 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29723553/a-strategic-tension-for-hospitals-moving-upstream-cede-control-but-maintain-accountability
#17
Lauren A Taylor, Caroline Morgan Berchuck, Katherine Gergen Barnett
Health systems are focusing attention on the role that social determinants of health (SDOH) can and should play in health care delivery. This is especially true among accountable care organizations (ACOs) and Medicaid ACOs in particular. In crafting SDOH strategies, senior leadership teams may face an organizational tension in aiming to cede control over dollars, data and patient experience to community-based organizations (CBOs) while also maintaining financial accountability for health outcomes. We review the history of neighborhood health centers (NHCs) in order to foreshadow the types of critiques ACOs are likely to face in working with CBOs...
April 30, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29720300/chronic-obstructive-pulmonary-disease-and-heart-failure-self-management-kits-for-outpatient-transitions-of-care
#18
Paul Boylan, Tina Joseph, Genevieve Hale, Cynthia Moreau, Matthew Seamon, Renee Jones
OBJECTIVE: To develop heart failure (HF) and chronic obstructive pulmonary disease (COPD) self-management kits in an accountable care organization (ACO) to facilitate patients' self-care and prevent hospital readmissions. SETTING: Pharmacists practice in an outpatient-based ACO. They participate in interprofessional office visits with providers and independently manage maintenance pharmacotherapies. PRACTICE DESCRIPTION: Pharmacists collaborate with an interprofessional team within the ACO including physicians, nurses, case managers, and paramedics...
March 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29713158/heterogeneity-of-asthma-and-copd-overlap
#19
Min-Hye Kim, Chin Kook Rhee, Kyungjoo Kim, Sang Hyun Kim, Jung Yeon Lee, Yee Hyung Kim, Kwang Ha Yoo, Young-Joo Cho, Ki-Suck Jung, Jin Hwa Lee
Background: Asthma and COPD are heterogeneous diseases. Patients with both disease features (asthma-COPD overlap [ACO]) are common. However, clinical characteristics and socio-economic burden of ACO are still controversial. The aim of this study was to identify the heterogeneity of ACO and to find out the subtypes with clinical impact among ACO subtypes. Methods: In the Korean National Health and Nutrition Examination Survey (KNHANES) conducted between 2007 and 2012, subjects who were ≥40 years and had prebronchodilator FEV1 /FVC <0...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29697952/in-situ-synthesis-of-cds-graphdiyne-heterojunction-for-enhanced-photocatalytic-activity-of-hydrogen-production
#20
Jia-Xin Lv, Zhi-Ming Zhang, Juan Wang, Xiu-Li Lu, Wen Zhang, Tong-Bu Lu
Hydrogen production through artificial photosynthesis has been regarded as a promising strategy for dealing with energy shortage and environmental problems. In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate. The as-prepared CdS/GD heterojunction exhibits much higher performance for photocatalytic hydrogen evolution compared to that of pristine GD and CdS nanoparticles...
April 26, 2018: ACS Applied Materials & Interfaces
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