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https://www.readbyqxmd.com/read/28320040/mitochondria-as-a-target-for-the-cardioprotective-effects-of-cydonia-oblonga-mill-and-ficus-carica-l-in-doxorubicin-induced-cardiotoxicity
#1
Saman Gholami, Mir-Jamal Hosseini, Leila Jafari, Fatemeh Omidvar, Mohammad Kamalinejad, Vida Mashayekhi, Seyed Hojjat Hosseini, Azin Kardan, Jalal Pourahmad, Mohammad Reza Eskandari
Quince (Cydonia oblonga Mill.) and fig (Ficus carica L.) exhibit a broad spectrum of pharmacological activities. Regarding the cardiotoxic effect of doxorubicin (DOX) is mediated mainly through mitochondrial oxidative stress and dysfunction; the present study evaluated the cardioprotective effects of the aqueous extracts of Cydonia oblonga Mill. fruit (ACO) and Ficus carica L. fruit (AFC) against DOX-induced cardiotoxicity. Cardiomyocytes toxicity was induced in male Sprague Dawley rats by intraperitoneal (ip) injections of 2...
March 20, 2017: Drug Research
https://www.readbyqxmd.com/read/28319986/perceived-ethics-dilemmas-among-pioneer-accountable-care-organizations
#2
Craig R Westling, Thom Walsh, William A Nelson
This study of Pioneer accountable care organizations (ACOs) suggests that the ACO model is creating moral distress for physicians and business leaders in seven critical ways:Despite an overall sense of optimism associated with the ACO model, our research identified an underlying sense of moral distress at most sites. A clear opportunity exists for ACOs to use a more comprehensive, coordinated approach to proactively resolving ethical dilemmas while continuing the march toward risk-based contracts.
January 2017: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28319619/cost-of-diagnosing-psoriasis-and-rosacea-for-dermatologists-versus-primary-care-physicians
#3
Dane Hill, Steven R Feldman
Growing incentives to control health care costs may cause accountable care organizations (ACOs) to reconsider how skin disease is best managed. Limited data have suggested that disease management by a primary care physician (PCP) may be less costly than seeing a specialist, though it is not clear if the same is true for the management of skin disease. This study assessed the cost of seeing a dermatologist versus a PCP for diagnosis of psoriasis and rosacea.
February 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28301037/primary-care-for-diabetes-mellitus-patients-from-the-perspective-of-the-care-model-for-chronic-conditions
#4
Maria Aparecida Salci, Betina Hörner Schlindwein Meirelles, Denise Maria Guerreiro Vieira da Silva
Objective: to assess the health care Primary Health Care professionals provide to diabetes mellitus patients from the perspective of the Modelo de Atenção às Condições Crônicas. Method: qualitative study, using the theoretical framework of Complex Thinking and the Modelo de Atenção às Condições Crônicas and the methodological framework of assessment research. To collect the data, 38 interviews were held with health professionals and managers; observation of the activities by the health teams; and analysis of 25 files of people who received this care...
March 9, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28301029/assessment-of-the-culture-of-safety-in-public-hospitals-in-brazil
#5
Rhanna Emanuela Fontenele Lima de Carvalho, Lidyane Parente Arruda, Nayanne Karen Pinheiro do Nascimento, Renata Lopes Sampaio, Maria Lígia Silva Nunes Cavalcante, Ana Carolina Pinto Costa
Objective: to assess the culture of safety in three public hospitals. Method: transversal study undertaken in three Brazilian public hospitals, with health professionals through applying the Safety Attitudes Questionnaire (SAQ). Scores greater than or equal to 75 were considered positive. Results: a total of 573 professionals participated in the study, including nurse technicians and auxiliary nurses 292 (51%), nurses 105 (18.3%), physicians 59 (10...
March 2, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28293840/assay-methods-for-acs-activity-and-acs-phosphorylation-by-map-kinases-in-vitro-and-in-vivo
#6
Xiaomin Han, Guojing Li, Shuqun Zhang
Ethylene, a gaseous phytohormone, has profound effects on plant growth, development, and adaptation to the environment. Ethylene-regulated processes begin with the induction of ethylene biosynthesis. There are two key steps in ethylene biosynthesis. The first is the biosynthesis of 1-aminocyclopropane-1-carboxylic acid (ACC) from S-Adenosyl-Methionine (SAM), a common precursor in many metabolic pathways, which is catalyzed by ACC synthase (ACS). The second is the oxidative cleavage of ACC to form ethylene under the action of ACC oxidase (ACO)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28287130/a-high-concentrate-diet-induced-milk-fat-decline-via-glucagon-mediated-activation-of-amp-activated-protein-kinase-in-dairy-cows
#7
Lin Li, Yang Cao, Zhenglu Xie, Yuanshu Zhang
Dairy cows are often fed a high-concentrate (HC) diet to meet lactation demands; however, long-term concentrate feeding is unhealthy and decreases milk fat. Therefore, we investigated the effects of liver lipid metabolism on milk fat synthesis. Ten lactating Holstein cows were assigned randomly into HC and LC (low-concentrate) diet groups. After 20 weeks of feeding, milk fat declined, and lipopolysaccharide levels in the jugular, portal, and hepatic veins increased in the HC group. Liver consumption and release of nonesterified fatty acid (NEFA) into the bloodstream also decreased...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28283854/management-of-the-asthma-copd-overlap-syndrome-acos-a-review-of-the-evidence
#8
REVIEW
Kristin L Hines, R Stokes Peebles
PURPOSE OF REVIEW: Examine the definition of the asthma-COPD overlap syndrome (ACOS) and current treatment strategies. RECENT FINDINGS: Patients with the ACOS have a lower quality of life and suffer from more complications than those affected by either disease alone. Diagnosis of ACOS is difficult because of the clinical similarities between the two diseases and the various phenotypes that comprise the syndrome. Defining treatment strategies for ACOS has been challenging because many clinical trials for asthma therapy have purposefully excluded patients with features of COPD, and COPD clinical trials have not included patients who might have an asthmatic component to their disease...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28282995/understanding-copd-overlap-syndromes
#9
Tuang Yeow Poh, Micheál Mac Aogáin, Adrian Kwok Wai Chan, Anthony Chau Ang Yii, Valerie Fei Lee Yong, Pei Yee Tiew, Mariko Siyue Koh, Sanjay Haresh Chotirmall
Chronic obstructive pulmonary disease accounts for a large burden of lung disease. It can 'overlap' with other respiratory diseases including bronchiectasis, fibrosis and obstructive sleep apnea (OSA). While COPD alone confers morbidity and mortality, common features with contrasting clinical outcomes can occur in COPD 'overlap syndromes'. Areas Covered: Given the large degree of heterogeneity in COPD, individual variation to treatment is adopted based on its observed phenotype, which in turn overlaps with features of other respiratory disease states such as asthma...
March 10, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28279063/symposium-oncology-leadership-in-asia
#10
Dong-Young Noh, Jae Kyung Roh, Yeul Hong Kim, Kazuhiro Yoshida, Hideo Baba, Marie Cherry Lynn Samson-Fernando, Sanjeev Misra, Zeba Aziz, Rainy Umbas, Yogendra P Singh, Tony Shu Kam Mok, Han-Kwang Yang, Hideyuki Akaza
The Symposium on "Oncology Leadership in Asia" was held as part of the official program of the 42nd Annual Meeting of the Korean Cancer Association. Given the increasing incidence of cancer in all countries and regions of Asia, regardless of developmental stage, and also in light of the recognized need for Asian countries to enhance collaboration in cancer prevention, research, treatment and follow-up, the symposium was held with the aim of bringing together oncology specialists from eight countries and regions in Asia to present the status in their own national context and discuss the key challenges and requirements in order to establish a greater Asian presence in the area of cancer control and research...
March 9, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28268257/risk-factors-for-incident-asthma-and-copd-in-a-cohort-of-young-adults
#11
Lisbet Krogh Traulsen, Jesper Baelum, Anders Halling, Gert Thomsen, Trine Thilsing, David Sherson, Torben Sigsgaard, Øyvind Omland, Tine Malling, Lars Rauff Skadhauge
INTRODUCTION: The aim of the study was to describe potential shared risk factors for incident asthma and COPD in a population-based, nine-year follow-up study. METHODS: From a cohort of 1,191 individuals, aged 20-44, who participated in baseline survey including spirometry, bronchial challenge, and skin prick test (SPT) 742 subjects (62%) were reexamined at follow-up in 2012-2014. RESULTS: A total of 27 incident cases of asthma and 22 cases of COPD were identified at follow-up corresponding to an incidence rate of 5...
March 7, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28264915/structural-analysis-of-the-role-of-tpx2-in-branching-microtubule-nucleation
#12
Raymundo Alfaro-Aco, Akanksha Thawani, Sabine Petry
The mitotic spindle consists of microtubules (MTs), which are nucleated by the γ-tubulin ring complex (γ-TuRC). How the γ-TuRC gets activated at the right time and location remains elusive. Recently, it was uncovered that MTs nucleate from preexisting MTs within the mitotic spindle, which requires the protein TPX2, but the mechanism basis for TPX2 action is unknown. Here, we investigate the role of TPX2 in branching MT nucleation. We establish the domain organization of Xenopus laevis TPX2 and define the minimal TPX2 version that stimulates branching MT nucleation, which we find is unrelated to TPX2's ability to nucleate MTs in vitro...
March 6, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28264789/optical-sensing-of-hydrogen-sulphate-using-rhodamine-6g-hydrazide-from-aqueous-medium
#13
Yachana Upadhyay, Shilpa Bothra, Rajender Kumar, Heung-Jin Choi, Suban K Sahoo
This communication reports the application of rhodamine 6G hydrazide (L) for the selective colorimetric and turn-on fluorescent sensing of hydrogen sulphate ions from aqueous medium. The ring opening of the colourless spirocyclic form of L was selectively triggered in the presence of HSO4(-) among the other tested anions (F(-), Cl(-), Br(-), I(-), AcO(-), H2PO4(-), NO3(-), ClO4(-), CN(-), HO(-), AsO3(3-) and SO4(2-)), which gives rise to a pink colour and strong fluorescence in the visible region. Sensor L showed a detection limit down to micromolar range without any interference from the other tested competitive anions...
February 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28263208/a-taxonomy-of-hospitals-participating-in-medicare-accountable-care-organizations
#14
Gloria J Bazzoli, David W Harless, Askar S Chukmaitov
BACKGROUND: Medicare was an early innovator of accountable care organizations (ACOs), establishing the Medicare Shared Savings Program (MSSP) and Pioneer programs in 2012-2013. Existing research has documented that ACOs bring together an array of health providers with hospitals serving as important participants. PURPOSE: Hospitals vary markedly in their service structure and organizational capabilities, and thus, one would expect hospital ACO participants to vary in these regards...
March 3, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28261248/comparative-transcriptomic-analysis-reveals-that-ethylene-h2o2-mediated-hypersensitive-response-and-programmed-cell-death-determine-the-compatible-interaction-of-sand-pear-and-alternaria-alternata
#15
Hong Wang, Jing Lin, Youhong Chang, Cai-Zhong Jiang
A major restriction on sand pear (Pyrus pyrifolia) production is black spot disease caused by the necrotrophic fungus Alternaria alternata. However, the pear response mechanism to A. alternata is unknown at the molecular level. Here, host responses of a resistant cultivar Cuiguan (CG) and a susceptible cultivar Sucui1 (SC1) to A. alternata infection were investigated. We found that the primary necrotic lesion formed at 1 dpi and the expansion of lesions was aggressive in SC1. Data from transcriptomic profiles using RNA-Seq technology identified a large number of differentially expressed genes (DEGs) between CG and SC1 in the early phase of A...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28260876/heterogeneity-of-asthma-copd-overlap-syndrome
#16
Hyonsoo Joo, Deokjae Han, Jae Ha Lee, Chin Kook Rhee
Many patients suffering from asthma or COPD have overlapping features of both diseases. However, a phenotypical approach for evaluating asthma-COPD overlap syndrome (ACOS) has not been established. In this report, we examined the phenotypes in patients with ACOS. Patients diagnosed with ACOS between 2011 and 2015 were identified and classified into four phenotype groups. Group A was composed of patients who smoked <10 pack years and had blood eosinophil counts ≥300. Group B was composed of patients who smoked <10 pack years and had blood eosinophil counts <300...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28255811/sagittal-lung-ct-measurements-in-the-evaluation-of-asthma-copd-overlap-syndrome-a-distinctive-phenotype-from-copd-alone
#17
Yanjuan Qu, Yiyuan Cao, Meiyan Liao, Zhiyan Lu
OBJECTIVES: This study aimed at investigating the capability of sagittal-lung computed tomography (CT) measurements in differentiating chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS). METHODS: Clinical and high-resolution CT of 229 patients including 123 pure COPD patients and 106 ACOS patients were included. Sagittal-lung CT measurements in terms of bilateral lung height (LH), anterior-posterior lung diameter (APLD), diaphragm height (DH), and anterior sterno-diaphragmatic angle (ASDA), as well as inter-pulmonary septum length (IPSL) on axial images were measured both before and after bronchodilator (BD) administration...
March 3, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28254707/harnessing-a-pyrimidine-based-molecular-switch-to-construct-reversible-test-strips-for-f-aco-with-respect-to-al-3-a-colorimetric-approach
#18
Arghyadeep Bhattacharyya, Soumen Ghosh, Subhash Chandra Makhal, Nikhil Guchhait
We report novel compound 4-nitro-2-((pyrimidin-2-ylamino) methyl) phenol (1) synthesized by the condensation of 5-nitro salicylaldehyde with 2-amino pyridine. Compound 1 serves as a dual signalling chromogenic receptor for F(-)/AcO(-) and Al(3+) ions. The chromogenic response of 1 towards the aforementioned analytes is reversible with respect to either Al(3+)/X (=F/AcO)(-) or X(F/AcO)(-)/Al(3+). The limit of detection of 1 for F(-) and AcO(-) are 1.0025×10(-7)M and 0.79×10(-7)M, respectively. The optical switching has been rationalized on the basis of UV-Vis titrations and (1)H NMR titrations respectively...
February 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28243078/a-belgian-survey-on-the-diagnosis-of-asthma-copd-overlap-syndrome
#19
Didier Cataldo, Jean-Louis Corhay, Eric Derom, Renaud Louis, Eric Marchand, Alain Michils, Vincent Ninane, Rudi Peché, Charles Pilette, Walter Vincken, Wim Janssens
INTRODUCTION: Patients with chronic airway disease may present features of both asthma and COPD, commonly referred to as asthma-COPD overlap syndrome (ACOS). Recommendations on their diagnosis are diffuse and inconsistent. This survey aimed to identify consensus on criteria for diagnosing ACOS. METHODS: A Belgian expert panel developed a survey on ACOS diagnosis, which was completed by 87 pulmonologists. Answers chosen by ≥70% of survey respondents were considered as useful criteria for ACOS diagnosis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28239746/induction-of-sa-signaling-pathway-and-ethylene-biosynthesis-in-trichoderma-harzianum-treated-tomato-plants-after-infection-of-the-root-knot-nematode-meloidogyne-incognita
#20
Paola Leonetti, Maria Chiara Zonno, Sergio Molinari, Claudio Altomare
Salicylic acid-signaling pathway and ethylene biosynthesis were induced in tomato treated with Trichoderma harzianum when infected by root-knot nematodes and limited the infection by activation of SAR and ethylene production. Soil pre-treatment with Trichoderma harzianum (Th) strains ITEM 908 (T908) and T908-5 decreased susceptibility of tomato to Meloidogyne incognita, as assessed by restriction in nematode reproduction and development. The effect of T. harzianum treatments on plant defense was detected by monitoring the expression of the genes PR-1/PR-5 and JERF3/ACO, markers of the SA- and JA/ET-dependent signaling pathways, respectively...
February 26, 2017: Plant Cell Reports
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