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https://www.readbyqxmd.com/read/29338973/asthma-copd-overlap-a-portuguese-survey
#1
E Padrão, D Araújo, A Todo Bom, C Robalo Cordeiro, J Correia de Sousa, J Cardoso, M Morais-Almeida, R Costa, F Pavão, R B Leite, A Marques
INTRODUCTION: The overlap between asthma and chronic obstructive pulmonary disease (COPD) (ACO) has been discussed for many years but clinical recommendations for this entity have been diverse. This study is intended to reach a consensus on diagnosis, treatment and patient orientation for ACO, within the Portuguese medical community. METHODS: This study was conducted by a multidisciplinary panel of experts from three distinct medical specialties (Pulmonology, Family Medicine and Immunoallergology)...
January 12, 2018: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/29313877/matriclans-shape-populations-insights-from-the-angolan-namib-desert-into-the-maternal-genetic-history-of-southern-africa
#2
Sandra Oliveira, Anne-Maria Fehn, Teresa Aço, Fernanda Lages, Magdalena Gayà-Vidal, Brigitte Pakendorf, Mark Stoneking, Jorge Rocha
OBJECTIVES: Southern Angola is a poorly studied region, inhabited by populations that have been associated with different migratory movements into southern Africa. Apart from Kx'a-speaking San foragers and Bantu-speaking pastoralists, ethnographic and linguistic studies have suggested the existence of an enigmatic array of pre-Bantu communities, like the Kwepe (formerly Khoe-Kwadi speakers), Twa and Kwisi. Here, we evaluate previous peopling hypotheses by assessing the relationships between different southern Angolan populations, based on newly collected linguistic data and complete mtDNA genomes...
January 3, 2018: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29290594/advanced-imaging-utilization-and-cost-savings-among-medicare-shared-savings-program-accountable-care-organizations-an-initial-exploratory-analysis
#3
Andrew B Rosenkrantz, Richard Duszak
INTRODUCTION: The purpose of this study was to explore associations between CT and MRI utilization and cost savings achieved by Medicare Shared Savings Program (MSSP)-participating accountable care organizations (ACOs). METHODS: Summary data were obtained for all MSSP-participating ACOs (n = 214 in 2013; n = 333 in 2014). Multivariable regressions were performed to assess associations of CT and MRI utilization with ACOs' total savings and reaching minimum savings rates to share in Medicare savings...
December 28, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29288956/sequential-and-simultaneous-strategies-for-biorefining-of-wheat-straw-using-room-temperature-ionic-liquids-xylanases-and-cellulases
#4
Eric Husson, Thomas Auxenfans, Mickael Herbaut, Manon Baralle, Virginie Lambertyn, Harivoni Rakotoarivonina, Caroline Rémond, Catherine Sarazin
Sequential and simultaneous strategies for fractioning wheat straw were developed in combining 1-ethyl-3-methyl imidazolium acetate [C2mim][OAc], endo-xylanases from Thermobacillus xylanilyticus and commercial cellulases. After [C2mim][OAc]-pretreatment, hydrolysis catalyzed by endo-xylanases of wheat straw led to efficient xylose production with very competitive yield (97.6 ± 1.3%). Subsequent enzymatic saccharification allowed achieving a total degradation of cellulosic fraction (>99%). These high performances revealed an interesting complementarity of [C2mim][OAc]- and xylanase-pretreatments for increasing enzymatic digestibility of cellulosic fraction in agreement with the structural and morphological changes of wheat straw induced by each of these pretreatment steps...
December 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29279273/bistachybotrysins-a-c-three-phenylspirodrimane-dimers-with-cytotoxicity-from-stachybotrys-chartarum
#5
Jinlian Zhao, Jiamin Feng, Zhen Tan, Jimei Liu, Min Zhang, Ridao Chen, Kebo Xie, Dawei Chen, Yan Li, Xiaoguang Chen, Jungui Dai
Bistachybotrysins A-C (1-3), three phenylspirodrimane dimers representing an unusual [6,6,7,6]-tetracyclic skeleton with a central 2,10-dioxabicyclo[4.3.1]decan-7-ol core fused with two phenyl units, were isolated from a fungal strain, Stachybotrys chartarum CGMCC 3.5365. The structures of 1-3 were elucidated through extensive spectroscopic data analysis, including Mo2(AcO)4-induced and calculated electronic circular dichroism (ECD). 1 and 2 exhibited potent cytotoxicity against four human tumor cell lines with IC50 values in the range of 2...
December 19, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29274987/anterior-capsulorhexis-opening-reduction-after-cataract-surgery-with-subluxated-lenses
#6
Juris Vanags, Renārs Erts, Guna Laganovska
BACKGROUND AND OBJECTIVE: This study sought to evaluate anterior capsulorhexis opening (ACO) reductions after surgery for a subluxated lens. Significant reduction of an ACO supports direct zonular involvement (capsular factors excluded by use of capsular tension rings [CTRs] and modern intraocular lens [IOLs]), and these findings question the long-term efficacy of subluxated lens surgery by means of cataract surgery. A small ACO due to lens mobility, non-enlargement of the ACO, and no lens epithelial cell washing due to an additional risk of further zonular damage were left as additional features to evaluate the possible outcomes of this simplified but still complicated surgery...
December 14, 2017: Medicina
https://www.readbyqxmd.com/read/29274632/medicare-program-medicare-shared-savings-program-extreme-and-uncontrollable-circumstances-policies-for-performance-year-2017-interim-final-rule-with-comment-period
#7
(no author information available yet)
This interim final rule with comment period establishes policies for assessing the financial and quality performance of Medicare Shared Savings Program (Shared Savings Program) Accountable Care Organizations (ACOs) affected by extreme and uncontrollable circumstances during performance year 2017, including the applicable quality reporting period for the performance year. Under the Shared Savings Program, providers of services and suppliers that participate in ACOs continue to receive traditional Medicare fee-for-service (FFS) payments under Parts A and B, but the ACO may be eligible to receive a shared savings payment if it meets specified quality and savings requirements...
December 26, 2017: Federal Register
https://www.readbyqxmd.com/read/29273668/investigating-fractional-exhaled-nitric-oxide-feno-in-chronic-obstructive-pulmonary-disease-copd-and-asthma-copd-overlap-aco-a-scoping-review-protocol
#8
Seyed-Mohammad-Yousof Mostafavi-Pour-Manshadi, Nafiseh Naderi, Miriam Barrecheguren, Abolfazl Dehghan, Jean Bourbeau
INTRODUCTION: During the last decade, many articles have been published, including reviews on fractional exhaled nitric oxide (FeNO) use and utility in clinical practice and for monitoring and identifying eosinophilic airway inflammation, especially in asthma, and evaluating corticosteroid responsiveness. However, the exact role of FeNO in patients with chronic obstructive pulmonary disease (COPD) and its ability to distinguish patients with COPD and those having concomitant asthma, that is, asthma-COPD overlap (ACO) is still unclear and needs to be defined...
December 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/29273476/gasdermin-d-plays-a-key-role-as-a-pyroptosis-executor-of-non-alcoholic-steatohepatitis-in-humans-and-mice
#9
Bing Xu, Mingzuo Jiang, Yi Chu, Weijie Wang, Di Chen, Xiaowei Li, Zhao Zhang, Di Zhang, Daiming Fan, Yongzhan Nie, Feng Shao, Kaichun Wu, Jie Liang
BACKGROUND & AIMS: Gasdermin D (GSDMD)-executed programmed necrosis is involved in inflammation and controls interleukin (IL)-1β release. However, the role of GSDMD in non-alcoholic steatohepatitis (NASH) remains unclear. We investigated the role of GSDMD in the pathogenesis of steatohepatitis. METHODS: Human liver tissues of non-alcoholic fatty liver disease (NAFLD) patients and control subjects were obtained to evaluate GSDMD expression. GSDMD knockout (GSDMD-/-) mice, obese db/db mice and their wild-type (WT) littermates were fed with methionine-and-choline-deficient (MCD) or control diet to induce steatohepatitis...
December 19, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29248621/asthma-is-a-risk-factor-for-respiratory-exacerbations-without-increased-rate-of-lung-function-decline-five-year-follow-up-in-adult-smokers-from-the-copdgene-study
#10
Lystra P Hayden, Megan E Hardin, Weiliang Qiu, David A Lynch, Matthew J Strand, Edwin J van Beek, James D Crapo, Edwin K Silverman, Craig P Hersh
BACKGROUND: Previous investigations in adult smokers from the COPDGene Study have shown that early-life respiratory disease is associated with reduced lung function, COPD, and airway thickening. Using five-year follow-up data we assessed disease progression in subjects with early-life respiratory disease. We hypothesized that there are alternative pathways to reaching reduced FEV1 and subjects with childhood pneumonia, childhood asthma, or asthma-COPD overlap (ACO), would have less lung function decline than subjects without these conditions...
December 14, 2017: Chest
https://www.readbyqxmd.com/read/29232717/the-relationship-of-depression-in-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#11
Jun-Jun Yeh, Cheng-Li Lin, Wu-Huei Hsu, Chia-Hung Kao
PURPOSE: To clarify the relationship between asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression. METHODS: We identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts...
2017: PloS One
https://www.readbyqxmd.com/read/29232135/the-equilibrium-in-protic-ionic-liquids-the-degree-of-proton-transfer-and-thermodynamic-properties
#12
Kaizhou Chen, Yongtao Wang, Jia Yao, Haoran Li
The degree of proton transfer and thermodynamic parameters of six acetate-based protic ionic liquids (PILs) were measured using nuclear magnetic resonance (NMR) spectroscopy and calculated by van't Hoff analytical method, respectively. The degree of proton transfer of these PILs at 298 K spread over a large range, which is from 39.6% (1-methylpyrrolidinium acetate, [MpyrH][AcO]) to 94.4% (1-butylimidazolium acetate, [BuimH][AcO]). The calculated standard enthalpy change of the reaction (∆_r H_m^θ) is from -23...
December 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29231131/impact-of-accountable-care-organizations-on-utilization-care-and-outcomes-a-systematic-review
#13
Brystana G Kaufman, B Steven Spivack, Sally C Stearns, Paula H Song, Emily C O'Brien
Since 2010, more than 900 accountable care organizations (ACOs) have formed payment contracts with public and private insurers in the United States; however, there has not been a systematic evaluation of the evidence studying impacts of ACOs on care and outcomes across payer types. This review evaluates the quality of evidence regarding the association of public and private ACOs with health service use, processes, and outcomes of care. The 42 articles identified studied ACO contracts with Medicare ( N = 24 articles), Medicaid ( N = 5), commercial ( N = 11), and all payers ( N = 2)...
December 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29229474/accuracy-of-a-new-algorithm-to-identify-asthma-copd-overlap-aco-patients-in-a-cohort-of-patients-with-chronic-obstructive-airway-disease
#14
Luis Pérez de Llano, Borja G Cosío, Marc Miravitlles, Vicente Plaza
OBJECTIVES: We aimed to characterize the clinical, functional and inflammatory features of patients diagnosed diagnosed with ACO according to a new algorithm and to compare them with those of other chronic obstructive airway disease (COAD) categories (asthma and COPD). METHODS: ACO was diagnosed in a cohort of COAD patients in those patients with COPD who were either diagnosed with current asthma or showed significant blood eosinophilia (≥300cells/μl) and/or a very positive bronchodilator response (>400ml and >15% in FEV1)...
December 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29216566/new-platinum-ii-and-palladium-ii-complexes-of-coumarin-thiazole-schiff-base-with-a-fluorescent-chemosensor-properties-synthesis-spectroscopic-characterization-x-ray-structure-determination-in-vitro-anticancer-activity-on-various-human-carcinoma-cell-lines-and
#15
Ömer Şahin, Ümmühan Özmen Özdemir, Nurgül Seferoğlu, Zuhal Karagöz Genc, Kerem Kaya, Burcu Aydıner, Suat Tekin, Zeynel Seferoğlu
A new coumarin-thiazole based Schiff base (Ligand, L) and its Pd(II), Pt(II) complexes; ([Pd(L)2] and [Pt(L)2]), were synthesized and characterized using spectrophotometric techniques (NMR, IR, UV-vis, LC-MS), magnetic moment, and conductivity measurements. A single crystal X-ray analysis for only L was done. The crystals of L have monoclinic crystal system and P21/c space group. To gain insight into the structure of L and its complexes, we used density functional theory (DFT) method to optimize the molecules...
November 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29214420/aerobic-reactions-of-antitumor-active-dirhodium-ii-tetraacetate-rh2-ch3coo-4-with-glutathione
#16
Alejandra Enriquez Garcia, Farideh Jalilehvand
The aerobic reaction between glutathione (H3A) and dirhodium(II) tetraacetate, Rh2(AcO)4 (AcO- = CH3COO-), in aqueous solution (pH 7.4) breaks up the direct RhII-RhII bond and its carboxylate framework, as evidenced by UV-Vis spectroscopy. After purifying the reaction product using size exclusion chromatography, electrospray ionization mass spectrometry (ESI-MS) of the solution showed binuclear [Formula: see text] and [Formula: see text] ions. Evaporation yielded a solid compound, [Formula: see text], for which Rh K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy revealed ~ 2 Rh-O (2...
December 6, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29211623/quality-of-care-improves-for-patients-with-diabetes-in-medicare-shared-savings-accountable-care-organizations-organizational-characteristics-associated-with-performance
#17
Taressa K Fraze, Valerie A Lewis, Emily Tierney, Carrie H Colla
Accountable care organizations (ACOs), a primary care-centric delivery and payment model, aim to promote integrated population health, which may improve care for those with chronic conditions such as diabetes. Research has shown that, overall, the ACO model is effective at reducing costs, but there is substantial variation in how effective different types of ACOs are at impacting costs and improving care delivery. This study examines how ACO organizational characteristics - such as composition, staffing, care management, and experiences with health reform - were associated with quality of care delivered to patients with diabetes...
December 6, 2017: Population Health Management
https://www.readbyqxmd.com/read/29210399/an-ion-pair-receptor-comprising-urea-groups-and-n-benzyl-aza-18-crown-6-effective-recognition-and-liquid-liquid-extraction-of-kcl-salt
#18
Maciej Zakrzewski, Dominika Załubiniak, Piotr Piątek
Compound 1 was designed and prepared as a heteroditopic ion-pair receptor that contains two urea groups for anion complexation and N-benzyl-18-crown-6 for cation recognition. These ion-binding domains are assembled together by the l-ornithine scaffold. Qualitative cation coordination studies of receptor 1, supported by quantitative data received for monotopic N-(3-nitrobenzyl)-aza-18-crown-6 (3a), have shown that 1 has a strong affinity for Na+, K+ and NH4+ cations. Anion binding studies revealed that in the absence of cations coordinated to 1 (TBA salts), anions are bound with a relatively moderate strength with the selectivity: BzO- > AcO- > Cl-> NO2- > Br-...
December 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29204975/characteristics-and-disparities-among-primary-care-practices-in-the-united-states
#19
David Michael Levine, Jeffrey A Linder, Bruce E Landon
BACKGROUND: Despite new incentives for US primary care, concerns abound that patient-centered practice capabilities are lagging. OBJECTIVE: Describe the practice structure, patient-centered capabilities, and payment relationships of US primary care practices; identify disparities in practice capabilities. DESIGN: Analysis of the 2015 Medical Organizations Survey (MOS), part of the nationally representative Medical Expenditure Panel Survey (MEPS)...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29200735/therapeutic-effects-of-cyathula-officinalis-kuan-and-its-active-fraction-on-acute-blood-stasis-rat-model-and-identification-constituents-by-hplc-qtof-ms-ms
#20
Yanmei Cao, Cuicui Gu, Fangli Zhao, Yuanlin Tang, Xiaobing Cui, Le Shi, Li Xu, Lian Yin
Background: Cyathula officinalis Kuan is widely used in the clinics for the treatment of blood stasis in China. Objective: To evaluate the improving blood rheology and anti-inflammatory properties of C. officinalis Kuan extract (CO) and its active fraction (ACO) on acute blood stasis model Wistar rats and characterize the correlative constituents. Materials and Methods: CO at 0.26, 0.53, and 1.04 g/kg and ACO at 0.38, 0.75, and 1.5 g/kg were administered to acute blood stasis model Wistar rats for 3 days...
October 2017: Pharmacognosy Magazine
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