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https://www.readbyqxmd.com/read/28993683/short-term-changes-in-the-proteome-of-human-cerebral-organoids-induced-by-5-meo-dmt
#1
Vanja Dakic, Juliana Minardi Nascimento, Rafaela Costa Sartore, Renata de Moraes Maciel, Draulio B de Araujo, Sidarta Ribeiro, Daniel Martins-de-Souza, Stevens K Rehen
Dimethyltryptamines are entheogenic serotonin-like molecules present in traditional Amerindian medicine recently associated with cognitive gains, antidepressant effects, and changes in brain areas related to attention. Legal restrictions and the lack of adequate experimental models have limited the understanding of how such substances impact human brain metabolism. Here we used shotgun mass spectrometry to explore proteomic differences induced by 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) on human cerebral organoids...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837531/preoperative-opioid-use-is-a-predictor-of-poor-return-to-work-in-workers-compensation-patients-after-lumbar-diskectomy
#2
Jeffrey A O'Donnell, Joshua T Anderson, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
STUDY DESIGN: Retrospective cohort. OBJECTIVE: Determine the impact of preoperative opioid use in workers' compensation (WC) patients undergoing lumbar diskectomy (LD). SUMMARY OF BACKGROUND DATA: The prevalence of back pain among opioid users approached 60%. Long term opioid dependence in spine surgery patients is roughly 20%. Despite pervasive use, there is no evidence to support long-term opioid analgesic use for back pain. METHODS: 10,592 patients received compensation from the Ohio Bureau of Workers' Compensation for a lumbar disc herniation between 2005-2012...
August 23, 2017: Spine
https://www.readbyqxmd.com/read/28731391/malpractice-litigation-following-spine-surgery
#3
Alan H Daniels, Roy Ruttiman, Adam E M Eltorai, J Mason DePasse, Bielinsky A Brea, Mark A Palumbo
OBJECTIVE Adverse events related to spine surgery sometimes lead to litigation. Few studies have evaluated the association between spine surgical complications and medical malpractice proceedings, outcomes, and awards. The aim of this study was to identify the most frequent causes of alleged malpractice in spine surgery and to gain insight into patient demographic and clinical characteristics associated with medical negligence litigation. METHODS A search for "spine surgery" spanning February 1988 to May 2015 was conducted utilizing the medicolegal research service VerdictSearch (ALM Media Properties, LLC)...
October 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28673825/the-medico-legal-landscape-of-spine-surgery-how-do-surgeons-fare
#4
Melvin C Makhni, Paul J Park, Jesus Jimenez, Comron S Saifi, Jon-Michael Caldwell, Alex Ha, Bianca Figueroa-Santana, Ronald A Lehman, Mark Weidenbaum
BACKGROUND CONTEXT: Due to the limited and confidential nature of most legal data, scarce literature is available to physicians about reasons for litigation in spine surgery. In order to optimally compensate patients while protecting physicians, further understanding of the medico-legal landscape is needed for high-risk procedures such as spine surgery. Based on these, surgeons can explore ways to better protect both their patients and themselves. PURPOSE: To characterize the current medico-legal environment of spine surgery by analyzing a recent dataset of malpractice litigation...
June 30, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28652118/analysis-of-patients-with-myelopathy-due-to-benign-intradural-spinal-tumors-with-concomitant-lumbar-degenerative-diseases-misdiagnosed-and-erroneously-treated-with-lumbar-surgery
#5
Kang Lu, Hao-Kuang Wang, Po-Chou Liliang, Chih-Hui Yang, Cheng-Yo Yen, Yu-Duan Tsai, Po-Yuan Chen, Cien-Leong Chye, Kuo-Wei Wang, Cheng-Loong Liang, Han-Jung Chen
OBJECTIVE: When a cervical or thoracic benign intradural spinal tumor (BIST) coexists with lumbar degenerative diseases (LDD), diagnosis can be difficult. Symptoms of BIST-myelopathy can be mistaken as being related to LDD. Worse, an unnecessary lumbar surgery could be performed. This study was conducted to analyze cases in which an erroneous lumbar surgery was undertaken in the wake of failure to identify BIST-associated myelopathy. METHODS: Cases were found in a hospital database...
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28627924/clusters-of-financially-incentivized-chronic-pain-patients-using-the-minnesota-multiphasic-personality-inventory-2-restructured-form-mmpi-2-rf
#6
Luis E Aguerrevere, Matthew R Calamia, Kevin W Greve, Kevin J Bianchini, Kelly L Curtis, Veronica Ramirez
The Minnesota Multiphasic Personality Inventory (MMPI)-2 Restructured Form (MMPI-2-RF) has been shown to have clinical utility in the assessment of individuals with chronic pain (e.g., predicting surgical outcomes). The purpose of this study was to explore the ability of the MMPI-2-RF Validity Scales in profiling patients with chronic pain who had external financial incentive (e.g., workers' compensation claims) and determine the associations between Validity Scale response patterns and important outcomes. Cluster analysis identified 2 similarly sized clusters of patients with very different MMPI-2-RF profiles...
June 19, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28498071/assessment-of-malpractice-claims-due-to-spinal-epidural-abscess
#7
J Mason DePasse, Roy Ruttiman, Adam E M Eltorai, Mark A Palumbo, Alan H Daniels
OBJECTIVE Spinal epidural abscesses (SEAs) can be difficult to diagnose and may result in neurological compromise or even death. Delays in diagnosis or treatment may worsen the prognosis. While SEA presents a high risk for litigation, little is known about the medicolegal ramifications of this condition. An enhanced understanding of potential legal implications is important for practicing spine surgeons, emergency medicine physicians, and internists. METHODS The VerdictSearch database, a large legal-claims database, was queried for "epidural abscess"-related legal cases...
October 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28359979/variation-in-selection-criteria-and-approaches-to-surgery-for-lumbar-spinal-stenosis-among-patients-treated-in-boston-and-norway
#8
Greger Lønne, Andrew J Schoenfeld, Thomas D Cha, Øystein P Nygaard, John Anker H Zwart, Tore Solberg
OBJECTIVES: There are no uniform guidelines regarding when to operate or the ideal surgical intervention in Lumbar Spinal Stenosis (LSS). Understanding the presence of practice-based variation between different localities is critical. We sought to compare patient-reported pre-operative pain, disability, and health-related quality of life as indications for surgery between Boston and Norway, and the use of decompression alone vs. decompression and arthrodesis. PATIENTS AND METHODS: This study included 3826 patients; 1886 from Boston and 1940 from Norway...
March 21, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28081582/-expert-evidence-in-whiplash-injury
#9
Florin M Bucur, Martin Schwarze, Marcus Schiltenwolf
The assessment of cervical spine injuries is not a problem - provided full evidence of primary physical damage can be ensured. MRI examinations of the cervical spine carried out soon after the accident provide the best evidence. The assessment is more difficult if only clinical abnormalities are documented by the doctors after the accident in the diagnosis of cervical spine distortion, as functional results of this type are not specific and are also common in the general population. The legal rules of evidence must be taken into account in the summary assessment of the consequences of cervical spine injuries...
January 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/27968857/surgical-treatment-of-patients-with-lung-cancer-and-bone-metastases-a-prospective-observational-study
#10
Wang Zhiyu, Zhang Rui, Wang Shuai, Zhao Hui
BACKGROUND: As life expectancy improves in patients with lung cancer and bone metastases, effective surgical treatment to relieve pain and improve quality of life and neurological function is increasingly needed. Indications for surgery in patients with bone metastases are controversial. We aimed to assess a protocol for the surgery of patients with lung cancer and bone metastases. METHODS: We developed a surgical protocol for both spinal and appendicular metastases...
October 2016: Lancet
https://www.readbyqxmd.com/read/27938361/evaluation-of-the-efficacy-of-a-short-course-personalized-self-management-and-intensive-spa-therapy-intervention-as-active-prevention-of-musculoskeletal-disorders-of-the-upper-extremities-muska-a-research-protocol-for-a-randomized-controlled-trial
#11
Charlotte Lanhers, Bruno Pereira, Chloé Gay, Christian Hérisson, Christine Levyckyj, Arnaud Dupeyron, Emmanuel Coudeyre
BACKGROUND: Musculoskeletal disorders (MSDs) constitute a major occupational health problem in the working population, substantially impacting the quality of life of employees. They also cause considerable economic cost to the healthcare system, with, notably, the reimbursement of treatments and compensation for lost income. MSDs manifest as localized pain or functional difficulty in one or more anatomical areas, such as the cervical spine, shoulder, elbow, hand, and wrist. Although prevalence varies depending on the region considered and the method of assessment, a prevalence of 30% is found in different epidemiological studies...
December 9, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27920614/spine-care-as-a-framework-for-the-chiropractic-identity
#12
REVIEW
Michael Schneider, Donald Murphy, Jan Hartvigsen
OBJECTIVE: The purpose of this commentary is to provide an argument for the role and identity of chiropractors as spine care providers within the context of the greater health care system. DISCUSSION: Surveys of the general public and chiropractors indicate that the majority of patients seek chiropractic services for back and neck pain. Insurance company utilization data confirm these findings. Regulatory and legal language found in chiropractic practice acts reveals that most jurisdictions define the chiropractic scope of practice as based on a foundation of spine care...
December 2016: Journal of Chiropractic Humanities
https://www.readbyqxmd.com/read/27885641/apophyseal-ossification-of-the-iliac-crest-in-forensic-age-estimation-computed-tomography-standards-for-modern-australian-subadults
#13
Nicolene Lottering, Clair L Alston-Knox, Donna M MacGregor, Maree T Izatt, Caroline A Grant, Clayton J Adam, Laura S Gregory
This study contrasts the ontogeny of the iliac crest apophysis using conventional radiography and multislice computed tomography (MSCT), providing probabilistic information for age estimation of modern Australian subadults. Retrospective abdominopelvic MSCT data acquired from 524 Australian individuals aged 7-25 and surveillance radiographs of adolescent idiopathic scoliosis patients included in the Paediatric Spine Research Group Progression Study (n = 531) were assessed. Ossification scoring of pseudo-radiographs and three-dimensional (3D) volume-rendered reconstructions using Risser (1958) quantitative descriptors indicate discrepancies in age estimates, stage allocation, and conflicting morphological progression...
November 25, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27747539/risk-factors-associated-with-legal-interventions
#14
Alfreda Holloway-Beth, Linda Forst, Julia Lippert, Sherry Brandt-Rauf, Sally Freels, Lee Friedman
BACKGROUND: Current research regarding injuries caused during interactions between police officers and civilians is conducted intermittently or on a very narrow sample frame which provides very little clinical information about the injuries suffered or the adverse outcomes. The aim of this study is to identify comorbid risk factors and describe acute outcomes of medically treated traumatic injuries occurring as a result of contact with law enforcement personnel. METHODS: For this retrospective study, patients injured as a result of contact with law enforcement personnel were identified using ICD-9 external cause of injury codes from medical record databases of patients treated in all hospitals and trauma units in Illinois between 2000 and 2009...
December 2016: Injury Epidemiology
https://www.readbyqxmd.com/read/27383337/health-conditions-of-prisoners-in-the-state-of-rio-de-janeiro-brazil
#15
Maria Cecília de Souza Minayo, Adalgisa Peixoto Ribeiro
We present the results of a quantitative and qualitative study on the living conditions and health of prisoners in the state of Rio de Janeiro. The goal was to produce strategic information to support the action of public officials who work in prisons. The results show that prisoners are young (average age: 30 years), poor, mostly black and brown (70.5%), have little education (only 1.5% of them have a higher education), and have been in prison for less than four years. Among the problems that indirectly affect their health, we emphasize: overcrowding (1...
June 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27172279/defensive-medicine-in-u-s-spine-neurosurgery
#16
Ryan S Din, Sandra C Yan, David J Cote, Michael A Acosta, Timothy R Smith
STUDY DESIGN: Observational cross-sectional survey. OBJECTIVE: To compare defensive practices of U.S. spine and nonspine neurosurgeons in the context of state medical liability risk. SUMMARY OF BACKGROUND DATA: Defensive medicine is a commonly reported and costly phenomenon in neurosurgery. Although state liability risk is thought to contribute greatly to defensive practice, variation within neurosurgical specialties has not been well explored...
February 2017: Spine
https://www.readbyqxmd.com/read/27108260/assessment-of-the-effectiveness-of-sfcr-patient-information-sheets-before-scheduled-spinal-surgery
#17
R Madkouri, M Grelat, A Vidon-Buthion, M Lleu, J Beaurain, K-L Mourier
INTRODUCTION: Patient information is an essential component of any surgical procedure as it allows the surgeon to collect informed consent. This is a legal obligation in the civil code and a professional obligation in the code of medical ethics. As a result, the French spinal surgery society (SFCR) decided to make a model information sheet available on the Internet. The goal of this prospective study was to evaluate the impact of this information sheet when given to patients before scheduled spinal surgery...
June 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27004163/new-regulations-for-medical-devices-rationale-advances-and-impact-on-research-and-patient-care
#18
Gerold Labek, Harald Schöffl, Christian Ioan Stoica
A series of events relating to inferior medical devices has brought about changes in the legal requirements regarding quality control on the part of regulators. Apart from clinical studies, register and routine data will play an essential role in this context. To ensure adequate use of these data, adapted methodologies are required as register data in fact represent a new scientific entity. For the interpretation of register and routine data several limitations of published data should be taken into account...
March 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/26924516/-aspects-of-expert-opinions-of-avulsion-fractures
#19
F Schröter
The apophyses as secondary ossification centers are connected with the bone by cartilage. During the growth phase of puberty, the apophyseal plate is a mechanical weak spot. Especially, apophyses in the hip and pelvic area are exposed to considerable tensile and sheer stresses due to the strong muscles which are inserted here. The frequency of injuries to the apophyses correlates with the extent of sporting activities. For athletes participating in "Youth Train for the Olympics", this is the most common injury of all...
March 2016: Der Orthopäde
https://www.readbyqxmd.com/read/26807346/risk-factors-associated-with-legal-interventions
#20
Alfreda Holloway-Beth, Linda Forst, Julia Lippert, Sherry Brandt-Rauf, Sally Freels, Lee Friedman
BACKGROUND: Current research regarding injuries caused during interactions between police officers and civilians is conducted intermittently or on a very narrow sample frame which provides very little clinical information about the injuries suffered or the adverse outcomes. The aim of this study is to identify comorbid risk factors and describe acute outcomes of medically treated traumatic injuries occurring as a result of contact with law enforcement personnel. METHODS: For this retrospective study, patients injured as a result of contact with law enforcement personnel were identified using ICD-9 external cause of injury codes from medical record databases of patients treated in all hospitals and trauma units in Illinois between 2000 and 2009...
2016: Injury Epidemiology
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