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https://www.readbyqxmd.com/read/28110182/a-large-taper-mismatch-is-one-of-the-key-factors-behind-high-wear-rates-and-failure-at-the-taper-junction-of-total-hip-replacements-a-finite-element-wear-analysis
#1
Ariyan Ashkanfar, David J Langton, Thomas J Joyce
Total hip replacement (THR) is one of the most successful orthopaedic surgeries; however, failures can occur due to adverse reactions to wear debris. Recently, a large number of failures linked to the release of metal particles from the taper junction between femoral head and femoral stem have been reported. One possible reason for this may be design variations such as taper mismatches associated with the taper and trunnion angles. Could a large taper mismatch lead to inappropriate contact mechanics and increase relative micromotion and thus wear? In this study, 3D finite element (FE) models of a commercial THR from a perfectly matched interface to large taper mismatches and a wear algorithm were used to investigate the extent of wear that could occur at this junction and identify the optimum tolerances in order to reduce the wear...
January 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28109654/spatial-and-temporal-variation-of-macro-meso-and-microplastic-abundance-on-a-remote-coral-island-of-the-maldives-indian-ocean
#2
Hannes K Imhof, Robert Sigl, Emilia Brauer, Sabine Feyl, Philipp Giesemann, Saskia Klink, Kathrin Leupolz, Martin G J Löder, Lena A Löschel, Jan Missun, Sarah Muszynski, Anja F R M Ramsperger, Isabella Schrank, Susan Speck, Sebastian Steibl, Benjamin Trotter, Isabel Winter, Christian Laforsch
Plastic debris is ubiquitous in the marine environment and the world's shores represent a major sink. However, knowledge about plastic abundance in remote areas is scarce. Therefore, plastic abundance was investigated on a small island of the Maldives. Plastic debris (>1mm) was sampled once in natural long-term accumulation zones at the north shore and at the high tide drift line of the south shore on seven consecutive days to quantify daily plastic accumulation. Reliable identification of plastic debris was ensured by FTIR spectroscopy...
January 18, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28109049/production-of-the-antibiotic-secondary-metabolite-solanapyrone-a-by-the-fungal-plant-pathogen-ascochyta-rabiei-during-fruiting-body-formation-in-saprobic-growth
#3
Wonyong Kim, Jeong-Jin Park, Frank M Dugan, Tobin L Peever, David R Gang, George Vandemark, Weidong Chen
Fungi are noted producers of a diverse array of secondary metabolites, many of which are of pharmacological importance. However, the biological roles of the vast majority of these molecules during the fungal life cycle in nature remain elusive. Solanapyrones are polyketide-derived secondary metabolites produced by diverse fungal species including the plant pathogen Ascochyta rabiei. This molecule was originally thought to function as a phytotoxin facilitating pathogenesis of A. rabiei. Chemical profiling and gene expression studies showed that solanapyrone A was specifically produced during saprobic, but not parasitic growth of A...
January 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28108576/dual-source-computed-tomography-based-analysis-of-stent-performance-its-association-with-valvular-calcification-and-residual-aortic-regurgitation-after-implantation-of-a-balloon-expandable-transcatheter-heart-valve
#4
Julius Gerstmeyer, Maximilian Kütting, Buntaro Fujita, Annika Schuhbäck, Martin Arnold, Jochen Börgermann, Stephan Achenbach, Ulrich Steinseifer, Jan Gummert, Stephan Ensminger
OBJECTIVES: The aim of this study was to investigate the mutual influence of valvular calcifications and transcatheter aortic valve stent geometry during and after implantation of a balloon-expandable SAPIEN(®)/SAPIEN XT(®) prostheses. Aortic valve calcification has been linked with adverse complications after transcatheter aortic valve implantation (TAVI). However, little is known about the fate of the calcifications after TAVI as well as its influence on transcatheter heart valve geometry...
January 20, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28106239/intravitreal-chemotherapy-in-the-management-of-vitreous-disease-in-retinoblastoma
#5
Hayyam Kiratli, İrem Koç, Ali Varan, Canan Akyüz
PURPOSE: To evaluate the therapeutic outcome of intravitreal melphalan injection in the management of vitreous disease in patients with retinoblastoma. We particularly aimed to assess whether higher melphalan dose with lower number of injections was more effective and associated with fewer side effects. METHODS: This retrospective, interventional, noncomparative, and nonrandomized study included 39 eyes of 37 patients. Vitreous seeds were classified as dust, sphere, and cloud types...
January 2, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28105760/aerosol-based-airway-epithelial-cell-delivery-improves-airway-regeneration-and-repair
#6
E Kardia, E S Ch'ng, B H Yahaya
Aerosol-based cell therapy has emerged as a novel and promising therapeutic strategy for treating lung diseases. The goal of this study was to determine the safety and efficacy of aerosol-based airway epithelial cell (AEC) delivery in the setting of acute lung injury induced by tracheal brushing in rabbit. 24 hours following injury, exogenous rabbit AECs were labelled with BrdU and aerosolized using the MicroSprayer® Aerosolizer into the injured airway. Histopathological assessments of the injury in the trachea and lungs were quantitatively scored (1 and 5 d after cell delivery)...
January 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28105717/beyond-food-the-multiple-pathways-for-inclusion-of-materials-into-ancient-dental-calculus
#7
Anita Radini, Efthymia Nikita, Stephen Buckley, Les Copeland, Karen Hardy
Dental calculus (mineralized dental plaque) was first recognised as a potentially useful archaeological deposit in the 1970s, though interest in human dental calculus as a resource material has increased sharply in the past few years. The majority of recent research has focused on the retrieval of plant microfossils embedded in its matrix and interpretation of these finds as largely the result of deliberate consumption of plant-derived food. However, while most of the material described in published works does represent food, dental calculus is in fact a "depositional environment" as material can enter the mouth from a range of sources...
January 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28104934/an-unusual-sigmoid-phytobezoar-in-a-patient-with-a-transplanted-kidney-a-case-report
#8
Paola Milillo, Angelo Pio Moffa, Vincenzo Bertozzi, Roberta Vinci, Luca Macarini
Bezoars are masses formed by the concretion of stomach contents or debris within the gastrointestinal tract. Bezoars are rare and account for only 0.4-4% of all cases of gastrointestinal obstruction and mainly occur in the stomach or small intestine. Intestinal obstruction caused by colonic bezoars is extremely rare. A 39-year-old man with a transplanted kidney came to the hospital because of abdominal pain, constipation, and distension. We performed an abdominal computed tomography scan and found an ovoid intraluminal mass with a mottled gas pattern in the distal sigmoid colon...
October 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28103642/subcutaneous-adipose-tissue-response-to-a-non-invasive-hyperthermic-treatment-using-a-1-060%C3%A2-nm-laser
#9
John W Decorato, Bo Chen, Rafael Sierra
BACKGROUND: We postulated that a hyperthermic treatment using a 1,060 nm laser can cause a controlled adipocyte injury resulting in non-invasive fat reduction. This three-part study identified treatment parameters for a safe and tolerable treatment, demonstrated short- and long-term tissue response, and assessed the potential of this treatment for non-invasive fat reduction. METHODS: In vivo temperature measurements were conducted prior to abdominoplasty via a thermal camera (for surface readings) and thermocouple needle (for subcutaneous readings)...
January 19, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28102826/ceramic-particle-engulfment-by-fibroblasts-does-not-alter-at-all-cell-behavior
#10
Pierre-Antoine Faye, Olivier Roualdes, Fabrice Rossignol, Daniel Jean Hartmann, Alexis Desmoulière
Despite many studies, the impact of ceramic particles on cell behavior remains still unclear. The aim of the present study was to investigate the effects of ceramic nano-sized particles on fibroblastic cells. Fibroblasts (dermal fibroblasts freshly isolated from skin samples and WI26 fibroblastic cells) were cultured in monolayer in the presence of alumina or cerium-zirconia particles (��� 50 nm diameter) at two concentrations (100 or 500 ��g.mL-1). Fluorescent alumina particles were also used. Cell morphology, cytoplasmic ceramic incorporation using confocal and transmission electron microscopy, and migration using silicon insert, were analyzed...
January 19, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28102447/analysing-a-mechanism-of-failure-in-retrieved-magnetically-controlled-spinal-rods
#11
Vasiliki C Panagiotopoulou, Stewart K Tucker, Robert K Whittaker, Harry S Hothi, Johann Henckel, Julian J H Leong, Thomas Ember, John A Skinner, Alister J Hart
PURPOSE: We aim to describe a mechanism of failure in magnetically controlled growth rods which are used for the correction of the early onset scoliosis. METHODS: This retrieval study involved nine magnetically controlled growth rods, of a single design, revised from five patients for metal staining, progression of scoliosis, swelling, fractured actuator pin, and final fusion. All the retrieved rods were radiographed and assessed macroscopically and microscopically for material loss...
January 19, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28100687/a-stripak-complex-mediates-axonal-transport-of-autophagosomes-and-dense-core-vesicles-through-pp2a-regulation
#12
Amanda L Neisch, Thomas P Neufeld, Thomas S Hays
Autophagy plays an essential role in the cellular homeostasis of neurons, facilitating the clearance of cellular debris. This clearance process is orchestrated through the assembly, transport, and fusion of autophagosomes with lysosomes for degradation. The motor protein dynein drives autophagosome motility from distal sites of assembly to sites of lysosomal fusion. In this study, we identify the scaffold protein CKA (connector of kinase to AP-1) as essential for autophagosome transport in neurons. Together with other core components of the striatin-interacting phosphatase and kinase (STRIPAK) complex, we show that CKA associates with dynein and directly binds Atg8a, an autophagosomal protein...
January 18, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28099780/the-genetic-architecture-of-defense-as-resistance-to-and-tolerance-of-bacterial-infection-in-drosophila-melanogaster
#13
Virginia M Howick, Brian P Lazzaro
Defense against pathogenic infection can take two forms: resistance and tolerance. Resistance is the ability of the host to limit a pathogen burden, whereas tolerance is the ability to limit the negative consequences of infection at a given level of infection intensity. Evolutionarily, a tolerance strategy that is independent of resistance could allow the host to avoid mounting a costly immune response and, theoretically, to avoid a coevolutionary arms race between pathogen virulence and host resistance. Biomedically, understanding the mechanisms of tolerance and how they relate to resistance could potentially yield treatment strategies that focus on health improvement instead of pathogen elimination...
January 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28098787/pathological-impairment-cell-cycle-arrest-and-apoptosis-of-thymus-and-bursa-of-fabricius-induced-by-aflatoxin-contaminated-corn-in-broilers
#14
Xi Peng, Shiping Bai, Xuemei Ding, Keying Zhang
This study aimed to evaluate the comparative effects of aflatoxin-contaminated corn on the thymus and bursa of Fabricius (BF) in chickens by detecting histopathological lesions, cell cycle phase distribution and apoptosis. A total of 900 COBB500 male broilers were randomly allocated into five groups. The experiment lasted for six weeks and the five dietary treatments consisted of uncontaminated corn (control), 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups...
January 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28097447/mannose-binding-lectin-mbl-codon-54-rs1800450-polymorphism-predisposes-towards-medium-vessel-vasculitis-in-patients-with-systemic-lupus-erythematosus
#15
Vir Singh Negi, Panneer Devaraju, Durga Prasanna Misra, Vikramraj K Jain, Jignesh Babulal Usdadiya, Paul T Antony, Reena Gulati
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multiple etiological factors. Mannose-binding lectin (MBL) plays a key role in innate immunity by activating antibody-independent lectin complement pathway, opsonisation, phagocytosis, and immune complex (IC) clearance. Genetic polymorphisms in the promoter and coding regions of MBL gene affect the circulatory levels and biological activity of MBL. Defects in MBL can lead to defective opsonisation and, hence, hamper clearance of apoptotic debris, the persistence of which can drive autoantibody formation in lupus...
January 17, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28093082/less-extrusion-debris-during-the-retreatment-of-curved-canals-using-twisted-files-with-higher-rotational-speeds-an-ex-vivo-study
#16
Mengdong Liu, Shijiang Xiong, Fei Tan, Yi Liu
BACKGROUND: Debris extrusion from the apical foramen can be problematic in severely curved canals. This study aimed to assess the use of Twisted Files (TF) at different rotational speeds during retreatment, compared with manual technique using Triple-Flex Files (TFF). METHODS: Forty-eight mesiobuccal root canals were randomized to four groups (n = 12 per group). In groups A, B, and C, gutta-percha was removed using TF at 500, 1000, and 1500 rpm, respectively, while it was removed using TFF in group D...
January 16, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28093080/efficacy-of-fluralaner-against-otodectes-cynotis-infestations-in-dogs-and-cats
#17
Janina Taenzler, Christa de Vos, Rainer K A Roepke, Régis Frénais, Anja R Heckeroth
BACKGROUND: The efficacy of fluralaner for the treatment of Otodectes cynotis infestations in dogs and cats was evaluated after oral (dogs) or topical administration (dogs and cats). Twenty-four dogs and sixteen cats were experimentally infested with O. cynotis and randomly allocated to equal sized groups (n = 8/group). Dog groups were treated once, either orally with fluralaner at a minimum dose of 25 mg/kg body weight, topically with fluralaner at a dose of 25 mg/kg body weight or topically with saline solution (control)...
January 16, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28089553/plastic-debris-straps-on-threatened-blue-shark-prionace-glauca
#18
Ana I Colmenero, Claudio Barría, Elisabetta Broglio, Salvador García-Barcelona
Juveniles of blue shark Prionace glauca caught in pelagic longlines targeting tuna and swordfish in the Atlantic Ocean and the Mediterranean Sea were found entangled with plastic straps around their gill region. The plastic debris were identified as strapping bands and caused several degrees of injuries on the dorsal musculature and pectoral fins. They were also obstructing the gill slits probably causing breathing issues. These records were uploaded in the web site seawatchers.org, and highlight the potential of citizen science in revealing the occurrence of such problems which could help to measure the effects of plastic debris on marine life...
January 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28088671/melatonin-attenuates-titanium-particle-induced-osteolysis-via-activation-of-wnt-%C3%AE-catenin-signaling-pathway
#19
Zichuan Ping, Xuanyang Hu, Liangliang Wang, Jiawei Shi, Yunxia Tao, Xiexing Wu, Zhenyang Hou, Xiaobin Guo, Wen Zhang, Huilin Yang, Yaozeng Xu, Zhirong Wang, Dechun Geng
: Wear debris-induced inhibition of bone regeneration and extensive bone resorption were common features in peri-prosthetic osteolysis (PPO). Here, we investigated the effect of melatonin on titanium particle-stimulated osteolysis in a murine calvariae model and mouse-mesenchymal-stem cells (mMSCs) culture system. Melatonin inhibited titanium particle-induced osteolysis and increased bone formation at osteolytic sites, confirmed by radiological and histomorphometric data. Furthermore, osteoclast numbers decreased dramatically in the low- and high-melatonin administration mice, as respectively, compared with the untreated animals...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28086806/age-related-macular-degeneration-associated-polymorphism-rs10490924-in-arms2-results-in-deficiency-of-a-complement-activator
#20
Sven Micklisch, Yuchen Lin, Saskia Jacob, Marcus Karlstetter, Katharina Dannhausen, Prasad Dasari, Monika von der Heide, Hans-Martin Dahse, Lisa Schmölz, Felix Grassmann, Medhanie Alene, Sascha Fauser, Harald Neumann, Stefan Lorkowski, Diana Pauly, Bernhard H Weber, Antonia M Joussen, Thomas Langmann, Peter F Zipfel, Christine Skerka
BACKGROUND: Age-related macular degeneration (AMD) is the leading cause of blindness in developed countries. The polymorphism rs10490924 in the ARMS2 gene is highly associated with AMD and linked to an indel mutation (del443ins54), the latter inducing mRNA instability. At present, the function of the ARMS2 protein, the exact cellular sources in the retina and the biological consequences of the rs10490924 polymorphism are unclear. METHODS: Recombinant ARMS2 was expressed in Pichia pastoris, and protein functions were studied regarding cell surface binding and complement activation in human serum using fluoresence-activated cell sorting (FACS) as well as laser scanning microscopy (LSM)...
January 5, 2017: Journal of Neuroinflammation
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