Reham Hammadi, Norbert Kúsz, Csilla Zsuzsanna Dávid, Zoltán Behány, László Papp, Lajos Kemény, Judit Hohmann, Lóránt Lakatos, Andrea Vasas
Ingenol mebutate, isolated from Euphorbia peplus , is an ingenane-type diterpenoid, primarily used for the topical treatment of actinic keratosis, a premalignant skin condition. The aim of our work was to investigate other Euphorbia species to find structurally similar diterpenes that can be used as alternatives to ingenol mebutate. Pharmacological investigation of Euphorbia candelabrum , Euphorbia cotinifolia , Euphorbia ramipressa , and Euphorbia trigona revealed the potent keratinocyte (HPV-Ker cell line) inhibitory activity of these spurge species...
June 14, 2021: Plants (Basel, Switzerland)