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https://www.readbyqxmd.com/read/29161665/switchable-electrochemiluminescence-aptasensor-coupled-with-resonance-energy-transfer-for-selective-attomolar-detection-of-hg-2-via-cdte-cds-dendrimer-probe-and-au-nanoparticle-quencher
#1
Bahareh Babamiri, Abdollah Salimi, Rahman Hallaj
In the present study, an ultrasensitive electrochemiluminescence (ECL) aptasensing assay for selective detection of Hg(2+) was designed. In this electrochemiluminescence resonance energy transfer (ECL-RET) approach, Fe3O4@SiO2/dendrimers/QDs exhibited amplified ECL emissions (switch "on" state) and with the hybridization between T-rich ssDNA(S1) immobilized on the Fe3O4@SiO2/dendrimers/QDs and AuNPs modified with complementary aptamer (AuNPs-S2), the ECL of QDs nanocomposites was efficiently quenched (switch "off" state)...
November 10, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29161638/to-what-extent-do-structural-changes-in-catalytic-metal-sites-affect-enzyme-function
#2
Yana Valasatava, Antonio Rosato, Nicholas Furnham, Janet M Thornton, Claudia Andreini
About half of known enzymatic reactions involve metals. Enzymes belonging to the same superfamily often evolve to catalyze different reactions on the same structural scaffold. The work presented here investigates how functional differentiation, within superfamilies that contain metalloenzymes, relates to structural changes at the catalytic metal site. In general, when the catalytic metal site is unchanged across the enzymes of a superfamily, the functional differentiation within the superfamily tends to be low and the mechanism conserved...
November 8, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29161611/the-application-of-ion-mobility-mass-spectrometry-to-metabolomics
#3
REVIEW
Xing Zhang, Kevin Quinn, Charmion Cruickshank-Quinn, Richard Reisdorph, Nichole Reisdorph
Mass spectrometry-based metabolomics is being increasingly utilized in various research fields including investigating human diseases, nutrition, industrial applications, and plant/natural products studies. Although new analytical approaches have enhanced the performance of metabolomic analyses, significant challenges associated with throughput, metabolome coverage, and compound identification still exist. Ion mobility mass spectrometry offers great potential for improving throughput and depth of coverage in metabolomics experiments...
November 18, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29161511/a-customizable-flow-injection-system-for-automated-high-throughput-and-time-sensitive-ion-mobility-spectrometry-and-mass-spectrometry-measurements
#4
Daniel J Orton, Malak M Tfaily, Ronald J Moore, Brian L LaMarche, Xueyun Zheng, Thomas L Fillmore, Rosalie K Chu, Karl K Weitz, Matthew E Monroe, Ryan T Kelly, Richard D Smith, Erin Shammel Baker
To better understand disease conditions and environmental perturbations, multi-omic studies combining proteomic, lipidomic, and metabolomic analyses are vastly increasing in popularity. In a multi-omic study, a single sample is typically extracted in multiple ways and various analyses are performed using different instruments. Thus, one sample becomes many measurements, making high throughput and reproducible evaluations a necessity. One way to address the numerous samples and varying instrumental conditions is to utilize a flow injection analysis (FIA) system for rapid sample injection...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29161496/ion-transport-across-biological-membranes-by-carborane-capped-gold-nanoparticles
#5
Marcin P Grzelczak, Stephen P Danks, Robert C Klip, Domagoj Belic, Adnana Zaulet, Casper Kunstmann-Olsen, Dan F Bradley, Tatsuya Tsukuda, Clara Viñas, Francesc Teixidor, Jonathan J Abramson, Mathias Brust
2-3 nm carborane-capped gold nanoparticles (Au/carborane NPs) can act as artificial ion transporters across biological membranes. The particles themselves are large hydrophobic anions that have the ability to disperse in aqueous media and to partition over both sides of a phospholipid bilayer membrane. Their presence therefore causes a membrane potential that is determined by the relative concentrations of particles on each side of the membrane according to the Nernst-Equation. The particles tend to adsorb to both sides of the membrane and can flip across if changes in membrane potential require their repartitioning...
November 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/29161371/long-term-remineralizing-effect-of-mi-paste-plus-on-regression-of-early-caries-after-orthodontic-fixed-appliance-treatment-a-12-month-follow-up-randomized-controlled-trial
#6
Moniek W Beerens, Jacob M Ten Cate, Mark J Buijs, Monique H van der Veen
Background: Casein-phosphopeptide-amorphous-calcium-fluoride-phosphate (CPP-ACFP) can remineralize subsurface lesions. It is the active ingredient of MI-Paste-Plus® (MPP). The long-term remineralization efficacy is unknown. Objective: To evaluate the long-term effect of MPP versus a placebo paste on remineralization of enamel after fixed orthodontic treatment over a 12-month period. Design: This trial was designed as a prospective, double-blinded, placebo-controlled RCT...
November 17, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29161304/proposal-for-a-common-nomenclature-for-fragment-ions-in-mass-spectra-of-lipids
#7
Josch K Pauling, Martin Hermansson, Jürgen Hartler, Klaus Christiansen, Sandra F Gallego, Bing Peng, Robert Ahrends, Christer S Ejsing
Advances in mass spectrometry-based lipidomics have in recent years prompted efforts to standardize the annotation of the vast number of lipid molecules that can be detected in biological systems. These efforts have focused on cataloguing, naming and drawing chemical structures of intact lipid molecules, but have provided no guidelines for annotation of lipid fragment ions detected using tandem and multi-stage mass spectrometry, albeit these fragment ions are mandatory for structural elucidation and high confidence lipid identification, especially in high throughput lipidomics workflows...
2017: PloS One
https://www.readbyqxmd.com/read/29161280/microbial-caddisfly-bioherm-association-from-the-lower-cretaceous-shinekhudag-formation-mongolia-earliest-record-of-plant-armoring-in-fossil-caddisfly-cases
#8
Tsolmon Adiya, Cari L Johnson, Mark A Loewen, Kathleen A Ritterbush, Kurt N Constenius, Cory M Dinter
Caddisfly larvae construct underwater protective cases using surrounding materials, thus providing information on environmental conditions in both modern and ancient systems. Microbial bioherms associated with caddisfly cases are found in the Berriassian-Hauterivian (~140-130 Ma) Shinekhudag Formation of Mongolia, and yield new insights into aspects of lacustrine paleoecosystems and paleoenvironments. This formation contains the earliest record of plant-armored caddisfly cases and a rare occurrence of microbial-caddisfly association from the Mesozoic...
2017: PloS One
https://www.readbyqxmd.com/read/29161051/a-new-avenue-for-limiting-degradation-in-nanoli4ti5o12-for-ultra-fast-charge-lithium-ion-batteries-hybrid-polymer-inorganic-particles
#9
Jean-Christophe Daigle, Yuichiro Asakawa, Mélanie Beaupré, René Vieillette, Dharminder Laul, Michel L Trudeau, Karim Zaghib
Lithium titanium oxide (Li4Ti5O12)-based cells are a very promising battery technology for ultra-fast charge-discharge and long-life cycle batteries. However, surface reactivity of lithium titanium oxide is still a problem in presence of organic electrolyte which may cause expansion of the pouch cell. In this study, we report on the development of a simple and economical ''grafting onto'' method for forming hybrid polymer-Li4Ti15O12 nanoparticles which can be successfully applied in lithium-ion batteries. This method utilizes a low-cost and scalable hydrophobic polymer which is required for industrial implantation...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29161046/heavy-metal-free-tannin-from-bark-for-sustainable-energy-storage
#10
Alolika Mukhopadhyay, Yucong Jiao, Rui Katahira, Peter N Ciesielski, Michael E Himmel, Hongli Zhu
A novel renewable cathode made from earth-abundant, low-cost materials can contribute to the intermittent storage needs of renewable energy based society. Inspired by Nature, we report for the first-time tannin as a cathode material. Our approach exploits the charge storage mechanism of the redox active quinone moiety. Tannins extracted from tree bark using environmental friendly aqueous solvents has the highest phenol content (5.56 mol g-1) among all the natural phenolic biopolymers, 5000 times higher than lignin...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29161025/e-h-e-b-si-c-bond-activation-by-tuning-structural-and-electronic-properties-of-phosphenium-cations
#11
Nemanja Đorđević, Rakesh Ganguly, Milena Petković, Dragoslav Vidović
In this work, strategic enhancement of electrophilicity of phosphenium cations for the purpose of small-molecule activation was described. Our synthetic methodology for generation of novel two-coordinate phosphorus(III)-based compounds [{C6H4(MeN)2C}2C·PR](2+) ([2a](2+), R = N(i)Pr2; [2b](2+), R = Ph) was based on the exceptional electron-donating properties of the carbodicarbene ligand (CDC). The effects of P-centered substituent exchange and increase in the overall positive charge on small substrate activation were comparatively determined by incorporating the bis(amino)phosphenium ion [((i)Pr2N)2P](+) ([1](+)) in this study...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29161021/recent-advances-in-solid-nano-pores-channel-analysis
#12
Zi Long, Shenshan Zhan, Pengcheng Gao, Yongqian Wang, Xiaoding Lou, Fan Xia
Inspired by the natural phenomenon that various types of transmembrane pores and ion channels in the range of 1-100 nm are found in each biological cell, playing crucial roles in various significant physiological activities such as maintaining cell osmotic balance and stabilizing cell volume, different biomimetic nanodevices (nano-pore/channel) with various characteristics have emerged as an attractive and powerful platform, and have been used for a wide range of applications. As the key components of any nano-pore/channel-based applications, the nano-pore/channel can be broadly sorted into two types, biological and solid state...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29161016/selective-voltage-gated-sodium-channel-peptide-toxins-from-animal-venom-pharmacological-probes-and-analgesic-drug-development
#13
Ying Wu, Hui Ma, Fan Zhang, Chun-Lei Zhang, Xiaohan Zou, Zhengyu Cao
Voltage-gated sodium channels (Navs) play critical roles in action potential generation and propagation. Nav channelopathy as well as pathological sensitization contribute to allodynia and hyperalgesia. Recent evidence has demonstrated the significant roles of Nav subtypes (Nav1.3, 1.7, 1.8 and 1.9) in nociceptive transduction and therefore these Navs may represent attractive targets for analgesic drug discovery. Animal toxins are structurally diverse peptides that are highly potent yet selective on ion channel subtypes and therefore representing valuable probes to elucidate the structures, gating properties and cellular functions of ion channels...
November 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29161005/esi-ms-for-microsized-bioparticles
#14
Abdil Ozdemir, Jung-Lee Lin, Mustafa Gulfen, Szu-Hsueh Lai, Chun-Jen Hsiao, Nelson Gee-Con Chen, Chung-Hsuan Chen
An ESI ion trap mass spectrometer was designed for high throughput and rapid mass analysis of large bio-particles. Mass calibration of the instrument was performed using commercially available polystyrene micro-particles, and the selected sizes of the polystyrene (PS) particles were approximately 3 to 15 µm, which is consistent with the size of the cancer cells selected for this work. It provides the analysis of micro-sized inorganic and bioparticles. Different sizes of MCF-7 breast cancer cells (8 to 15 µm) were used in this study...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160934/highly-efficient-perovskite-solar-cells-based-on-zn2ti3o8-nanoparticles-as-electron-transporting-material-with-efficiency-over-17
#15
Zhong-Ning Chen, Aiying Pang, Deli Shen, Mingdeng Wei
Developing ternary metal oxides as electron transporting layers (ETL) for perovskite solar cell is highly challenging in the field of third-generation photovoltaics. In this study, highly mesoporous zinc titanate oxide (Zn2Ti3O8) scaffold synthesized by ion-exchange method has been successfully used as ETL for the fabrication of methyl ammonium lead halide (CH3NH3PbI3) perovskite solar cells. The optimized devices exhibit 17.21% power conversion efficiency (PCE) with open circuit voltage (Voc) of 1.02 V, short-circuit current density (Jsc) of 21...
November 21, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29160888/iron-iii-complexes-of-2-methyl-6-pyrimidin-2-yl-hydrazonomethyl-phenol-as-spin-crossover-molecular-materials
#16
Juan Yuan, Mei-Jiao Liu, Cai-Ming Liu, Hui-Zhong Kou
Four new mononuclear Fe(iii) complexes 1-4 of 2-methyl-6-(pyrimidin-2-yl-hydrazonomethyl)-phenol (H2L) have been synthesized and characterized by magnetic susceptibility measurements and single-crystal X-ray diffraction analysis. Complexes 1-3 are ionic compounds with the formula [Fe(HL)2]X·nsolvent (X = ClO4(-) (1), BF4(-) (2) and Cl(-) (3)), while complex 4 ([Fe(HL)(L)]) is neutral. The central Fe(iii) ion in complexes 1-4 is coordinated by four nitrogen and two oxygen atoms of two Schiff base ligands HL(-) or L(2-), and the coordination geometries of Fe(III) are all distorted octahedral...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29160872/zinc-ii-cobalt-ii-and-manganese-ii-networks-with-phosphoserine-ligand-synthesis-crystal-structures-and-magnetic-and-proton-conductivity-properties
#17
J Vallejo, I R Salcedo, R M P Colodrero, A Cabeza, A Switlicka, J Cano, M Viciano-Chumillas
A series of zinc(ii), cobalt(ii) and manganese(ii) coordination networks with phosphoserine ligand (H3PSer) are synthesized and characterized. Whereas in compounds 1 and 2 with the general formula [M(HPser)]n [M = Zn (1) and Co (2)], the metal(ii) ion presents a tetrahedral geometry, in [Co(HPSer)(H2O)2]n (3) and [Mn(HPSer)(H2O)]n (4), the metal(ii) ions are in a distorted octahedral geometry. The 3D frameworks are formed by inorganic layers built up from MO4 or MO6 polyhedra and phosphate groups. These layers are linked by the carboxylate groups of the phosphoserine ligand...
November 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29160831/a-novel-detection-method-of-human-serum-albumin-based-on-the-poly-thymine-templated-copper-nanoparticles
#18
Mingjian Chen, Xinying Xiang, Kefeng Wu, Hailun He, Hanchun Chen, Changbei Ma
In this work, we developed a facile fluorescence method for quantitative detection of human serum albumin (HSA) based on the inhibition of poly(thymine) (poly T)-templated copper nanoparticles (CuNPs) in the presence of HSA. Under normal circumstances, poly T-templated CuNPs can display strong fluorescence with excitation/emission peaks at 340/610 nm. However, in the presence of HSA, it will absorb cupric ion, which will prevent the formation of CuNPs. As a result, the fluorescence intensity will become obviously lower in the presence of HSA...
November 21, 2017: Sensors
https://www.readbyqxmd.com/read/29160703/ruthenium-carbon-rich-group-as-a-redox-switchable-metal-coupling-unit-in-linear-trinuclear-complexes
#19
Emmanuel Di Piazza, Corentin Boilleau, Antoine Vacher, Khalissa Merahi, Lucie Norel, Karine Costuas, Thierry Roisnel, Sylvie Choua, Philippe Turek, Stéphane Rigaut
The preparation and properties of novel ruthenium carbon-rich complexes [(Ph-C≡C-)2-nRu(dppe)2(-C≡C-bipyM(hfac)2)n] (n = 1, 2; M = Cu(II), Mn(II); bipy = 2,2'-bipyridin-5-yl) characterized by single-crystal X-ray diffraction and designed for molecular magnetism are reported. With the help of EPR spectroscopy, we show that the neutral ruthenium system sets up a magnetic coupling between two remote paramagnetic Cu(II) units. More specifically, these copper compounds are unique examples of bimetallic and linear heterotrimetallic compounds for which a complete rationalization of the magnetic interactions could be made for exceptionally long distances between the spin carriers (8...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29160465/patient-satisfaction-with-pharmaceutical-services-in-brazilian-primary-health-care
#20
Orlando Mario Soeiro, Noêmia Urruth Leão Tavares, José Miguel do Nascimento, Augusto Afonso Guerra, Ediná Alves Costa, Francisco de Assis Acurcio, Ione Aquemi Guibu, Juliana Álvares, Margô Gomes de Oliveira Karnikowski, Silvana Nair Leite, Karen Sarmento Costa
OBJECTIVE: To evaluate patient satisfaction with pharmaceutical services in Brazilian primary health care. METHODS: This is a cross-sectional, exploratory, and evaluative study on a representative sample from the five Brazilian geopolitical regions resulting from the Pesquisa Nacional sobre Acesso, Utilização e Promoção do Uso Racional de Medicamentos - Serviços, 2015 (PNAUM - National Survey on Access, Use and Promotion of Rational Use of Medicines - Services, 2015)...
November 13, 2017: Revista de Saúde Pública
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