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discoid lupus erythematosus

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https://www.readbyqxmd.com/read/29894527/discoid-lupus-erythematosus-following-herpes-zoster
#1
Cynthia O Anyanwu, Lacy L Sommer, Halyna Kuzyshyn, Jeanette M Camacho, Hala M Eid, Warren R Heymann
The isomorphic response is the appearance of new lesions from a preexisting skin condition at a site of trauma. Discoid lupus erythematosus (DLE) may develop on traumatized skin and also may arise at sites of a prior cutaneous eruption. We report the case of a 20-year-old woman with a history of systemic lupus erythematosus (SLE) and DLE who developed a painful, multidermatomal, vesicular rash on the left breast and back consistent with herpes zoster (HZ) during treatment with systemic immunosuppression. Four months after the HZ resolved, the patient developed new-onset DLE lesions within the prior HZ-affected dermatomes...
May 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29885539/intravenous-immunoglobulins-as-a-new-opportunity-to-treat-discoid-lupus-erythematosus-a-case-report-and-review-of-the-literature
#2
REVIEW
Sara Tenti, Marta Fabbroni, Virginia Mancini, Filomena Russo, Mauro Galeazzi, Antonella Fioravanti
Discoid lupus erythematosus (DLE) is a chronic dermatological disease that can lead to scarring, alopecia and dyspigmentation, if not properly treated. Actually, no drugs are specifically approved for the treatment of CLE, although the first-line therapy usually consists of photoprotection associated to topical or oral steroids, topical calcineurin inhibitors and hydroxychloroquine (HCQ). In cases of DLE refractory to these medications, many other agents have been employed, such as dapsone, methotrexate, azathioprine, cyclophosphamide, biologic drugs and Intravenous Immunoglobulin (IVIG)...
June 6, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29882080/s-1-induced-discoid-lupus-erythematosus-like-lesions-and-long-term-complete-response-for-para-aortic-lymph-node-recurrence-of-pancreatic-ductal-adenocarcinoma-a-case-report
#3
Ryosuke Yamaga, Koji Tezuka, Shuichiro Sugawara, Toshihiro Watanabe, Ichiro Hirai, Tamio Suzuki, Wataru Kimura
BACKGROUND: Metastatic recurrence after resection of pancreatic cancer is considered to be an incurable disease, and discoid lupus erythematosus (DLE)-like lesions are known as a side effect of fluorouracil agents. We report a very rare case of metastatic recurrence of pancreatic cancer in a Japanese man with DLE-like lesions in which long-term complete response was achieved through S-1 monotherapy. CASE PRESENTATION: A 65-year-old man who had undergone distal pancreatectomy with splenectomy for pancreatic body cancer and had received adjuvant gemcitabine developed postoperative para-aortic lymph node recurrence 17 months after surgery...
June 7, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29873082/jak-stat-signaling-pathway-inhibition-a-role-for-treatment-of-discoid-lupus-erythematosus-and-dermatomyositis
#4
Jared S Kahn, Sandhya Chowdary Deverapalli, David M Rosmarin
BACKGROUND: Discoid lupus erythematosus (DLE) and dermatomyositis (DM) are inflammatory autoimmune diseases that manifest primarily in the skin but can be linked to systemic complications. Although there is an in-depth understanding of the clinical presentation of these two diseases, much less is known regarding the pathophysiology. This has limited the effective treatment options for patients. OBJECTIVE: An understanding of the pathogenesis of each disease in greater detail will lead to newer targeted medications with less morbidity...
June 5, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29872685/new-biochip-immunofluorescence-test-for-the-serological-diagnosis-of-pemphigus-vulgaris-and-foliaceus-a-review-of-the-literature
#5
REVIEW
Rachel R Xuan, Anes Yang, Dedee F Murrell
The immunoassays that are available for the serological diagnosis of the more common subtypes of autoimmune blistering diseases such as pemphigus vulgaris (PV) and pemphigus foliaceus (PF) include enzyme-linked immunosorbent assay (ELISA) testing to specific antigens desmoglein (Dsg)1 and Dsg3, direct immunofluorescence (DIF), indirect immunofluorescence (IIF), and immunoblotting. A review of the literature on the biochip assay was conducted. Six studies investigated the validity of a new biochip, mosaic-based, IIF test in patients with pemphigus and demonstrated its relatively high sensitivity and specificity (Dsg3: 97...
June 2018: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29858874/a-rare-case-with-prominent-features-of-both-discoid-lupus-erythematosus-and-pemphigus-foliaceus
#6
Aslı Bilgic Temel, Erkan Ergün, Angelique M Poot, Cumhur Ibrahım Bassorgun, Ayşe Akman-Karakaş, Soner Uzun, Erkan Alpsoy, Hendri H Pas, Marcel F Jonkman
The actual concurrence of lupus erythematosus (LE) and pemphigus is a rare phenomenon, that is different from pemphigus erythematosus (PE), which is a variant of pemphigus foliaceus (PF) with LE-like features (1,2). Here, we present a case that has both discoid lupus erythematosus (DLE) and PF. This article is protected by copyright. All rights reserved.
June 2, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#7
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29723351/coexistence-of-chronic-cutaneous-lupus-erythematosus-and-frontal-fibrosing-alopecia
#8
Luciana Lima do Nascimento, Milvia Maria Simões E Silva Enokihara, Mônica Ribeiro de Azevedo Vasconcellos
Lupus erythemathosus is a chronic, relapsing disease with acute, subacute, and chronic lesions. Effluvium telogen occurs in the setting of systemic activity of the disease, and cicatricial alopecia results from discoid lesionsin on the scalp. Other types of alopecia, like alopecia areata, may rarely be found in lupus. Frontal fibrosing alopecia is characterized by frontotemporal hairline recession and eybrow loss. Histophatologically, it cannot be differentiated from lichen planopilaris.It is controversial whether frontal fibrosing alopecia is a subtype of lichen planopilaris...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29719023/maximizing-the-clinical-utility-of-descriptive-lymphoid-pathology-reporting
#9
Timothy H McCalmont
Dermatopathology reporting can be both exact and inexact. Exact reporting represents the use of terminology that corresponds to a disease sui generis, such as discoid lupus erythematosus or disseminated superficial porokeratosis. Inexact reporting can vary greatly amongst various practitioners-both in terms of the exact semantics used and also stylistically-and can be used habitually by pathologists as a means to provide cover for diagnostic uncertainty or inexperience. This article explores the use of descriptive (inexact) reporting as it applies to cutaneous lymphoma and its differential diagnosis...
March 2018: Seminars in Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29700807/clinical-and-dermoscopic-spectrum-of-discoid-lupus-erythematosus-novel-observations-from-lips-and-oral-mucosa
#10
Eman Salah
BACKGROUND: Under dermoscopy, discoid lupus erythematosus (DLE) exhibits specific findings. Commonly DLE lesions affect sun-exposed sites, especially the face. However, most of the dermoscopic reports come from scalp DLE. To our knowledge, the dermoscopic pattern for mucosal and labial DLE has not been previously reported. METHODS: This study included 20 patients with histopathologically confirmed DLE lesions. Full history taking was obtained with photo documentation of lesions including the sites involved, the number of lesions per site, and the total number of lesions affecting every patient...
April 27, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29676592/pulsed-dye-laser-as-an-adjuvant-treatment-for-discoid-lupus-erythematosus-a-randomized-controlled-trial
#11
Pawinee Rerknimitr, Nucharin Tekacharin, Ratchathorn Panchaprateep, Jade Wititsuwannakul, Pattarin Tangtanatakul, Nattiya Hirankarn, Pravit Asawanonda
PURPOSE: To evaluate the efficacy and safety of pulsed-dye laser (PDL) for discoid lupus erythematosus (DLE) in a double blinded, randomized, controlled fashion. METHOD: Forty-eight DLE lesions from nine patients were recruited. The lesions on one side of the body were randomized into the treatment group and the other side served as a control. Treatments with the PDL (595 nm) were delivered every four weeks for four consecutive months. The patients were evaluated at weeks 0, 4, 8, 12, 16 and 24...
May 10, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29669547/cutaneous-lupus-erythematosus-in-dogs-a-comprehensive-review
#12
REVIEW
Thierry Olivry, Keith E Linder, Frane Banovic
Since the first description of discoid lupus erythematosus (LE) in two dogs in 1979, the spectrum of canine cutaneous lupus erythematosus (CLE) variants has expanded markedly.In this review, we first propose an adaptation of the Gilliam-Sontheimer classification of CLE for dogs. We then review the signalment, clinical signs, laboratory and histopathology and treatment outcome of the currently recognized variants of canine CLE, which are vesicular CLE, exfoliative CLE, mucocutaneous LE and facial or generalized discoid LE...
April 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29669194/racial-disparities-in-the-incidence-of-primary-chronic-cutaneous-lupus-erythematosus-in-the-southeastern-united-states-the-georgia-lupus-registry
#13
Cristina Drenkard, Sareeta Parker, Laura D Aspey, Caroline Gordon, Charles G Helmick, Gaobin Bao, S Sam Lim
OBJECTIVE: Relative to SLE, epidemiologic studies on chronic cutaneous lupus erythematosus (CCLE) are rare and limited to populations without racial diversity. We sought to provide minimum estimates of the incidence of primary CCLE (CCLE in absence of SLE) in a predominantly white and black population in the Southestern United States. METHODS: The Georgia Lupus Registry used multiple sources for case finding, including dermatology and rheumatology practices, multispecialty healthcare facilities, and dermatopathology reports...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668590/a-case-report-of-lupus-erythematosus-tumidus-converted-from-discoid-lupus-erythematosus
#14
Xiaomei Chen, Sheng Wang, Li Li
RATIONALE: Lupus erythematosus tumidus (LET) is an uncommon type of cutaneous lupus erythematosus (CLE) that is rarely associated with other forms of lupus erythematosus. PATIENT CONCERNS: We report a 62-year-old Chinese man presented with recurrent erythematous facial plaques for 1 year and a low-grade fever for 1 week. He had been diagnosed as discoid lupus erythematosus (DLE) 1 year before. Physical examination showed diverse lesions, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29644204/verrucous-disseminated-discoid-lupus-erythematosus-with-plantar-and-oral-lesions-in-the-absence-of-systemic-lupus-erthyematosus
#15
Sruthy Manikkath, Raman Balakrishna Venkatta, Sukumaran Pradeep Nair, Gopinathan Nanda Kumar
No abstract text is available yet for this article.
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29599669/x-linked-tlr7-gene-polymorphisms-are-associated-with-diverse-immunological-conditions-but-not-with-discoid-lupus-erythematosus-in-polish-patients
#16
Katarzyna Skonieczna, Anna Woźniacka, Rafał Czajkowski, Jan Styczyński, Anna Krenska, Ewa Robak, Mariusz Gawrych, Sebastian Kaszewski, Mariusz Wysocki, Tomasz Grzybowski
Introduction: Toll-like receptor 7 (TLR7) is an important molecule involved in the development of autoimmunity and the response to different pathogens. Several polymorphisms within the TLR7 gene were previously found to be associated with systemic lupus erythematosus (SLE). However, none of those studies investigated the TLR7 promoter flanking variants rs1634318 and rs1616583. TLR7 gene diversity has not been analyzed with respect to discoid lupus erythematosus (DLE) development, while its role in the human immunological response to fungal infection is not fully known...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29579358/a-22-year-old-woman-with-systemic-lupus-erythematosus-presents-with-two-damaged-kidneys-one-seizure-no-platelets-and-many-possible-diagnoses
#17
Lisa Zickuhr, Leal C Herlitz, Soumya Chatterjee
A 22-year-old woman with a history of systemic lupus erythematosus (SLE) was admitted with progressive edema. Two years before hospitalization, a local rheumatologist diagnosed her with SLE based on a syndrome of oral ulcers, inflammatory arthritis, discoid lupus lesions, and Raynaud phenomenon. Serum analysis revealed high-titer anti-nuclear antibodies, the presence of anti-SSA, anti-SSB, anti-Smith, anti-RNP, anti-histone, and anti-double-stranded DNA antibodies, and low complement (C3 and C4) levels. Hydroxychloroquine and topical clobetasol ointment were started...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29472590/elevated-serum-interleukin-34-level-in-patients-with-systemic-lupus-erythematosus-is-associated-with-disease-activity
#18
Huan Huan Xie, Hui Shen, Li Zhang, Mei Ying Cui, Li Ping Xia, Jing Lu
We measured the interleukin-34 (IL-34) level in sera from patients with systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) using an enzyme-linked immunosorbent assay (ELISA). Blood tests, including assays to determine C-reactive protein (CRP), complement (C) 3, C4, immunoglobulin (Ig) A, IgG, IgM, anti-double-stranded DNA antibody (Anti-dsDNA Ab) and hemoglobin (Hb) levels and white blood cell (WBC) and platelet (PLT) counts, were performed using standard methods. Lupus nephritis (LN) was diagnosed according to the American College of Rheumatology (ACR) renal criteria...
February 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29469721/lupus-and-scleroderma-overlap-features-in-a-28-year-old-man-with-anti-pl-12-anti-synthetase-syndrome
#19
Jasmine Rana, Andrea Primiani Moy, Adriano Piris, Gideon P Smith
A 28-year-old man with clinically and laboratory diagnosed anti-PL-12 anti-synthetase syndrome (AS) in 2009 developed cutaneous lupus lesions, discoid lupus lesions, and sclerodacytly with finger-tip ulcerations four years following his AS diagnosis. Laboratory tests including +ANA, +anti-dsDNA antibody, +anti-Smith antibody, and +anti-RNP antibody in 2014 confirmed the diagnosis of progression to an overlap syndrome including systemic lupus erythematosus. The patient now also has clinical findings (sclerodacytly, Raynaud phenomenon, finger-tip ulcerations) consistent with scleroderma overlap...
September 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29460700/the-lupus-patient-with-positive-rheumatoid-factor
#20
A Fedrigo, T A F G Dos Santos, R Nisihara, T Skare
Background Patients with systemic lupus erythematosus (SLE) may form clusters with clinical manifestations and autoantibodies. Objective The objective of this report is to study whether SLE patients with positive rheumatoid factor (RF) have a special clinical and/or serological profile. Methods A retrospective study of 467 SLE patients seen at a single rheumatology unit was conducted. Epidemiological data (age, gender, age at disease onset, ethnic background and tobacco use), clinical data (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia, arthritis and hypothyroidism) and serological profile (anti-dsDNA, anti-Ro/SS-A, anti-La/SS-B, anti-RNP, anti-Sm, IgG aCL, IgM aCL, lupus anticoagulant, direct Coombs and RF) were collected...
July 2018: Lupus
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