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discoid lupus erythematosus

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https://www.readbyqxmd.com/read/27837197/comparison-of-ethnicity-gender-age-of-onset-and-outcome-in-south-africans-with-systemic-lupus-erythematosus
#1
A Budhoo, G M Mody, T Dubula, N Patel, P G Mody
Ethnicity, gender and age of onset are reported to influence the expression and outcome of systemic lupus erythematosus. We studied a multi-ethnic cohort of 408 South Africans (91.2% females) comprising 237 (58.1%) Indians, 137 (33.6%) African Blacks, 17 (4.2%) Mixed ethnicity and 17 (4.2%) Whites. The most common manifestations were arthritis (80.6%), photosensitivity (67.2%), oral ulcers (50.0%), malar rash (49.0%) and renal (39.2%). The common laboratory findings were positive anti-nuclear factor (96.8%), haematological (74...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27837194/lenalidomide-for-refractory-cutaneous-manifestations-of-pediatric-systemic-lupus-erythematosus
#2
E Y Wu, L E Schanberg, E C Wershba, C E Rabinovich
OBJECTIVE: Cutaneous manifestations of pediatric systemic lupus erythematosus cause significant morbidity. Lenalidomide, a thalidomide analogue, has shown promise treating cutaneous lupus erythematosus in adults. Our objective was to evaluate lenalidomide's efficacy and safety in treating refractory cutaneous manifestations of pediatric systemic lupus erythematosus. METHODS: We performed a retrospective chart review of 10 adolescents who received lenalidomide for recalcitrant cutaneous lupus erythematosus...
November 10, 2016: Lupus
https://www.readbyqxmd.com/read/27829463/frequency-and-predictors-of-the-lupus-low-disease-activity-state-in-a-multi-national-and-multi-ethnic-cohort
#3
Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Alfred Lok Lee, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V Navarra, Leonid Zamora, Yeong-Jian Wu, Laniyati Hamijoyo, Madelynn Chan, Sean O'Neill, Fiona Goldblatt, Eric Francis Morand, Mandana Nikpour
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity state (LLDAS) has been recently reported, with retrospective validation showing that time spent in LLDAS translates to reduced damage accrual. The objectives of this study were to describe the frequency and identify the predictors of attaining LLDAS in a large multinational cohort of patients with SLE...
November 9, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27747960/clinical-and-microscopic-features-of-generalized-discoid-lupus-erythematosus-in-dogs-10-cases
#4
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
December 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27730061/dermoscopy-of-discoid-lupus-erythematosus
#5
Abhijeet K Jha, Sidharth Sonthalia, Rashmi Sarkar
No abstract text is available yet for this article.
September 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27681518/estrogen-receptor-alpha-gene-esr1-polymorphism-can-contribute-to-clinical-findings-in-systemic-lupus-erythematosus-patients
#6
M N Drehmer, D Andrade, I A Pereira, A R Marrero, Y C N Muniz, I R de Souza, S E Löfgren
BACKGROUND: Estrogens have a modulatory effect on several immune responses, many of which are correlated to autoimmune diseases. Estrogens act through binding to their receptors, and an overexpression of these receptors has been identified in patients with different autoimmune diseases. Here we analyzed the association of a putative functional genetic variant in the main estrogen receptor (ERα) gene (ESR1), and the susceptibility to clinical findings and severity of SLE. METHODS: A total of 426 individuals (266 healthy controls and 160 SLE patients) were genotyped for the polymorphism rs2234693 in the ESR1 gene...
September 27, 2016: Lupus
https://www.readbyqxmd.com/read/27673387/eccrine-duct-dilation-as-a-marker-of-cicatricial-alopecia
#7
Timothy Tan, Joan Guitart, Pedram Gerami, Pedram Yazdan
BACKGROUND: Eccrine duct dilation (EDD) and syringoma-like sweat duct proliferation have been described as reactive changes occurring in a variety of skin conditions. However, extensive evaluation of EDD in scalp biopsies performed for alopecia has not been performed. METHODS: We retrospectively examined 129 cases of cicatricial alopecia (lichen planopilaris, central centrifugal cicatricial alopecia, and discoid lupus erythematosus) and 130 cases of noncicatricial alopecias (androgenetic alopecia, telogen effluvium, and alopecia areata) for the presence of EDD...
September 26, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27660939/addison-disease-and-discoid-lupus-erythematosus-a-rare-association-of-polyglandular-autoimmune-syndrome-type-ii
#8
Emily Baumrin, Guy Webster, Victoria P Werth
No abstract text is available yet for this article.
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27646883/lupus-skin-is-primed-for-il-6-inflammatory-responses-through-a-keratinocyte-mediated-autocrine-type%C3%A2-i%C3%A2-interferon-loop
#9
Jasmine N Stannard, Tamra J Reed, Emily Myers, Lori Lowe, Mrinal K Sarkar, Xianying Xing, Johann E Gudjonsson, J Michelle Kahlenberg
Cutaneous lupus erythematosus is a disfiguring and common manifestation in systemic lupus erythematosus, and the etiology of this predisposition for cutaneous inflammation is unknown. Here, we sought to examine the keratinocyte as an important source of IL-6 and define the mechanism for its increased production in cutaneous lupus erythematosus. Evaluation of discoid and subacute cutaneous lupus erythematosus lesions showed significant epidermal up-regulation of IL-6 compared with control via real-time PCR and immunohistochemistry...
September 16, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27617504/mutilating-squamous-cell-carcinoma-a-rare-complication-of-an-early-plaque-of-discoid-lupus-erythematosus
#10
S Kaur, P Sahu, S Dayal, V K Jain, N Jindal, V Jairath
Cutaneous Squamous cell carcinoma (SCC) is the second most common form of non-melanotic skin cancer after basal cell carcinoma (BCC). It is a well-known complication of discoid lupus erythematosus (DLE) and usually favours the depigmented lesions located over sun-exposed areas. The clinical course of this complication may be aggressive, with a high risk of mortality. Literature describes numerous case reports of SCC complicating the lesions of DLE but mutilating SCC is rarely mentioned. Here in, we report a rare case of mutilating squamous cell carcinoma arising in an early (two years duration) lesion of DLE...
February 22, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27613297/dermoscopy-in-general-dermatology-a-practical-overview
#11
REVIEW
Enzo Errichetti, Giuseppe Stinco
Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon's plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea)...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27610262/squamous-cell-cancer-arising-in-an-african-american-male-cheek-from-discoid-lupus-a-rare-case-and-review-of-the-literature
#12
Emanuel A Shapera, Paul D Kim
A 50-year-old African American male with Discoid Lupus Erythematosus (DLE) presented to the dermatology clinic for a rapidly enlarging left cheek mass. The mass failed to resolve with conservative measures. A biopsy revealed poorly differentiated Squamous Cell Carcinoma (SCC). He was referred to Head and Neck Surgery and successfully underwent a resection with free flap reconstruction. Postoperatively he did well. Squamous cell skin carcinomas arising from lesions of Discoid Lupus are rare and aggressive tumors with greater likelihood of metastases...
2016: Case Reports in Surgery
https://www.readbyqxmd.com/read/27557471/apoptosis-of-keratinocytes-and-serum-dnase-i-activity-in-patients-with-cutaneous-lupus-erythematosus-relationship-with-clinical-and-immunoserological-parameters
#13
D Skiljevic, B Bonaci-Nikolic, D Brasanac, M Nikolic
BACKGROUND: Dysregulation of apoptosis has an important role in the induction of autoimmunity. OBJECTIVE: To evaluate the influence of keratinocyte apoptosis and deoxyribonuclease I (DNase I) activity on the clinical and immunoserological parameters of cutaneous lupus erythematosus (CLE). METHODS: We studied 69 CLE patients (39 with discoid LE (DLE), 12 with subacute CLE (SCLE), 12 with acute and 6 with intermittent CLE). 30/69 patients fulfilled criteria for systemic LE (SLE)...
August 24, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27431977/cutaneous-characteristics-and-association-with-antinuclear-antibodies-in-402-patients-with-different-subtypes-of-lupus-erythematosus
#14
N Patsinakidis, T Gambichler, N Lahner, K Moellenhoff, A Kreuter
BACKGROUND: Lupus erythematosus (LE) is an autoimmune disease characterized by a heterogeneous spectrum of skin manifestations and organ affection, and is frequently associated with serum autoantibodies, which mostly remain positive through the course of the disease. The classification of LE is still a controversial topic. OBJECTIVES: To examine the prevalence and long-term course of autoantibodies in patients with cutaneous LE (CLE) and/or systemic LE (SLE) treated in the outpatient clinic for connective tissue diseases of the department of Dermatology in Bochum, Germany...
December 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27380773/atypical-clinical-presentation-of-primary-and-secondary-cutaneous-follicle-center-lymphoma-fcl-on-the-head-characterized-by-macular-lesions
#15
Cesare Massone, Regina Fink-Puches, Lorenzo Cerroni
BACKGROUND: Primary cutaneous follicle center lymphoma (pcFCL) usually presents with reddish nodules, plaques, and tumors on the head and neck or the back. OBJECTIVE: We sought to describe a peculiar clinical presentation of pcFCL and secondary cutaneous follicle center lymphoma (FCL). METHODS: We report a series of 13 patients (7 male and 6 female; median age 58 years, mean age 58.2 years, age range 26-83 years) with either pcFCL (11 patients) or secondary cutaneous FCL (2 patients) presenting with lesions on the head deviating from the classic clinical manifestations characterized by plaques and tumors...
July 2, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27332581/systemic-lupus-erythematosus
#16
Lynne Pearce
Essential facts Systemic lupus erythematosus (SLE) is a rare, chronic autoimmune disease that causes inflammation in various parts of the body. Its annual incidence is estimated at one in 20,000. Although there is no cure, early diagnosis and appropriate treatment can help to control the symptoms, preventing damage to vital organs. In addition, there are other types of lupus that affect the skin, including discoid lupus erythematosus and subacute cutaneous lupus erythematosus.
June 22, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27297280/relevance-of-trichoscopy-in-the-differential-diagnosis-of-alopecia-a-cross-sectional-study-from-north-india
#17
Minu Jose Chiramel, Vinod Kumar Sharma, Sujay Khandpur, Vishnubhatla Sreenivas
BACKGROUND: Trichoscopy is an office tool used in the diagnosis of alopecia but its utility has not been assessed. OBJECTIVES: To compare the trichoscopic characteristics of different types of alopecia, identify features of diagnostic value, and to determine the utility of trichoscopy in the diagnosis of alopecia. METHODS: A descriptive cross-sectional study was performed in patients with alopecia. After clinical assessment and relevant investigations, trichoscopy was performed using a non-polarized trichoscope (×10)...
November 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27276740/lupus-damage-and-waist-circumference-as-the-independent-risk-factors-for-cardiovascular-disease-in-sle-patients-from-phramongkutklao-hospital
#18
Wittaya Siricheepchaiyan, Pongthorn Narongroeknawin, Rattapon Pakchotanon, Paijit Asavatanabodee, Sumapa Chaiamnuay
BACKGROUND: Cardiovascular disease (CVD) has been reported to be a major cause of both morbidity and premature mortality in systemic lupus erythematosus (SLE) patients. OBJECTIVE: To determine the prevalence of cardiovascular disease and associated risk factors in Thai SLE patients from Phramongkutklao Hospital, Thailand. MATERIAL AND METHOD: A retrospective cross-sectional study was performed to investigate the frequency of CVD in SLE patients in Phramongkutklao Hospital on the basis of medical record documentation...
March 2016: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/27274545/lupus-erythematosus-and-localized-scleroderma-coexistent-at-the-same-sites-a-rare-presentation-of-overlap-syndrome-of-connective-tissue-diseases
#19
Anabella Pascucci, Peter J Lynch, Nasim Fazel
Overlap syndromes are known to occur with connective-tissue diseases (CTDs). Rarely, the overlap occurs at the same tissue site. We report the case of a patient with clinical and histopathologic findings consistent with the presence of discoid lupus erythematosus (DLE) and localized scleroderma within the same lesions. Based on our case and other reported cases in the literature, the following features are common in patients with an overlap of lupus erythematosus (LE) and localized scleroderma: predilection for young women, photodistributed lesions, DLE, linear morphology clinically, and positivity along the dermoepidermal junction on direct immunofluorescence...
May 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27240861/podoplanin-expression-is-correlated-with-the-progression-of-chronic-discoid-lupus-erythematosus-to-lip-squamous-cell-carcinoma
#20
Xing Gao, Liwei Ma, Zengtong Zhou, Xinchun Jian, Wei Liu
Chronic lip discoid lupus erythematosus (DLE) is a potentially malignant disorder that can develop into lip squamous cell carcinoma (LSCC). Podoplanin is a specific marker for lymphatic endothelial cells and plays a role in cancer progression. The objective of this study was to determine the immunoexpression of podoplanin in samples of patients with DLE and its correlation with the risk of progression to LSCC. In a retrospective study, podoplanin expression was determined using immunohistochemistry in samples from 52 patients with DLE, including 44 patients with untransformed DLE and 8 patients with malignant transformed DLE...
October 2016: International Journal of Surgical Pathology
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