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https://www.readbyqxmd.com/read/29782055/clinical-and-immunological-effects-of-adsorptive-myeloid-lineage-leukocyte-apheresis-in-patients-with-immune-disorders
#1
REVIEW
Takuro Kanekura
Adsorptive granulocyte and monocyte apheresis (GMA) with the Adacolumn® is an extracorporeal treatment, which uses cellulose acetate (CA) beads as adsorptive leukocytapheresis carriers designed to remove elevated and potentially activated myeloid lineage leukocytes. Reports on the clinical efficacy of GMA in patients with skin lesions have appeared in the published work. Dermatological diseases, which are known to respond to GMA, include pyoderma gangrenosum, skin lesions of Behçet's disease, rheumatoid arthritis, pustular psoriasis, psoriatic arthritis, adult-onset Still's disease, Sweet's syndrome, cutaneous allergic vasculitis and systemic lupus erythematosus rashes...
May 21, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29772801/ogt-o-glcnac-transferase-selectively-modifies-multiple-residues-unique-to-lamin-a
#2
Dan N Simon, Amanda Wriston, Qiong Fan, Jeffrey Shabanowitz, Alyssa Florwick, Tejas Dharmaraj, Sherket B Peterson, Yosef Gruenbaum, Cathrine R Carlson, Line M Grønning-Wang, Donald F Hunt, Katherine L Wilson
The LMNA gene encodes lamins A and C with key roles in nuclear structure, signaling, gene regulation, and genome integrity. Mutations in LMNA cause over 12 diseases ('laminopathies'). Lamins A and C are identical for their first 566 residues. However, they form separate filaments in vivo, with apparently distinct roles. We report that lamin A is β- O -linked N -acetylglucosamine- (O -GlcNAc)-modified in human hepatoma (Huh7) cells and in mouse liver. In vitro assays with purified O -GlcNAc transferase (OGT) enzyme showed robust O -GlcNAcylation of recombinant mature lamin A tails (residues 385⁻646), with no detectable modification of lamin B1, lamin C, or 'progerin' (Δ50) tails...
May 17, 2018: Cells
https://www.readbyqxmd.com/read/29761780/-sweet-syndrome-manifestations
#3
Lina Zeraiq, Kim Hein Lindahl, Anette Bygum
Sweet syndrome (SS) exists as classical, malignancy-associated, drug-induced and as the new variants: giant cellulitis-like SS and neutrophilic dermatosis of the hands. SS exhibits different morphologies. Skin manifestations are usually accompanied by fever and neutrocytosis. All variants respond to systemic corticosteroids, but SS can recur. SS may be the first sign of malignancy or recurrence of previous cancer. It is important to be aware of the disease, which may mimic other reactive and febrile diseases, to enable patients to obtain the correct diagnostic set-up and treatment...
May 14, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29761532/dermatological-aspects-of-tularaemia-a-study-of-168-cases
#4
M Polat, T Karapınar, F Sırmatel
BACKGROUND: Tularaemia is a zoonotic infectious disease caused by Francisella tularensis, an aerobic, uncapsulated, gram-negative coccobacillus. Several case reports have appeared on the dermatological manifestations of tularaemia, but relatively few longer-term studies are available. AIM: To identify skin features of tularaemia that aid in its diagnosis. METHODS: In total, 168 patients (68 male, 100 female) diagnosed with tularaemia were retrospectively examined...
May 14, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29750627/the-need-of-interdisciplinary-approach-for-the-treatment-of-children-with-down-syndrome-with-severe-caries-unintentionally-facilitated-by-hypotonia-therapy
#5
Enrique Bimstein, Camilla Miskovich
This manuscript describes a case of a 4-year-old child with Down syndrome involving hypotonia in which the use of sweets to induce oral muscular function contributed to the need to extract all the primary teeth due to extensive caries. The need for interdisciplinary education and practice targeted to the treatment of children with special health care needs is emphasized.
May 11, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29738655/-dietary-patterns-and-metabolic-syndrome-components-in-women-with-excess-weight-18-to-45-years-old
#6
Zugey Hernández-Ruiz, Sonia Rodríguez-Ramírez, Sonia Hernández-Cordero, Eric Monterrubio-Flores
OBJECTIVE: To analyze the association between dietary patterns and metabolic syndrome (MS) components in adult women with excess weight. MATERIAL AND METHODS: Cross-sectional study with anthropometric, dietary, biochemical and blood pressure data. Dietary patterns were identified by factor analysis and multiple logistic regression models were used to analyze associations. RESULTS: The prevalence of altered glucose was 14.6%, of hypertriglyceridemia 40...
March 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29729238/simmering-below-the-surface-sweet-s-syndrome-with-multiple-myeloma-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#7
Eric K Singhi, Benjamin C Li, Joshua C Denny
No abstract text is available yet for this article.
May 2, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29701234/skin-manifestations-in-patients-with-adult-onset-immunodeficiency-due-to-anti-interferon-gamma-autoantibody-a-relationship-with-systemic-infections
#8
Kamonwan Jutivorakool, Prattana Sittiwattanawong, Kornpaka Kantikosum, Cameron P Hurst, Chanat Kumtornrut, Pravit Asawanonda, Jettanong Kleawsongkram, Pawinee Rerknimitr
Adult-onset immunodeficiency due to anti-interferon-γ autoantibody is an emerging acquired immunodeficiency with frequent skin manifestations. A retrospective chart review was conducted and identified 41 patients with the syndrome. Skin involvement was detected in 33 (80%) patients, 15 (45%) with infective skin diseases and 27 (82%) with reactive skin disorders. Reactive lesions were mostly neutrophilic dermatoses e.g. Sweet syndrome. Of note, the presence of neutrophilic dermatoses was highly associated with infections of other sites...
April 27, 2018: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29698346/a-mixed-presentation-of-serotonin-syndrome-vs-neuroleptic-malignant-syndrome-in-a-12-year-old-boy
#9
Christie Sun, Hannah Sweet, Alicia B Minns, Desiree Shapiro, Willough Jenkins
BACKGROUND: Neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS) are serious medical conditions associated with commonly prescribed psychiatric medications. Although the mechanisms differ, they can be clinically difficult to distinguish. We report a case of a pediatric patient with complicated psychiatric history that developed features of both syndromes in the setting of polypharmacy. CASE: A 12-year-old boy with a history of developmental delay, attention-deficit hyperactivity disorder, and posttraumatic stress disorder presented to the emergency department with behavior changes consisting of delayed reactions, gait instability, drooling, and slowed movements...
April 24, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29683894/histiocytoid-sweet-s-syndrome-during-combined-therapy-with-braf-and-mek-inhibitors-for-metastatic-melanoma
#10
Daniel Morgado-Carrasco, Natalia Moreno-Rivera, Xavier Fustà-Novell, Adriana García-Herrera, Cristina Carrera, Susana Puig
No abstract text is available yet for this article.
June 2018: Melanoma Research
https://www.readbyqxmd.com/read/29661175/adherence-to-the-qatar-dietary-guidelines-a-cross-sectional-study-of-the-gaps-determinants-and-association-with-cardiometabolic-risk-amongst-adults
#11
Mohammed Al Thani, Al Anoud Al Thani, Walaa Al-Chetachi, Badria Al Malki, Shamseldin A H Khalifa, Ahmad Haj Bakri, Nahla Hwalla, Farah Naja, Lara Nasreddine
BACKGROUND: The Qatar Dietary Guidelines (QDGs) were developed as part of the national strategy to prevent chronic diseases. This study aims at characterizing gaps between the QDGs and usual dietary and lifestyle patterns in Qatar, identifying demographic and socioeconomic determinants of adherence to the QDGs and investigating the association between adherence and cardiometabolic risk. METHODS: This study is based on the Qatar National STEPwise cross-sectional survey which was conducted on a nationally representative sample of Qatari adults, aged 18 to 64 years (n = 1109)...
April 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29653210/neutrophilic-dermatoses-part-i-pathogenesis-sweet-syndrome-neutrophilic-eccrine-hidradenitis-and-beh%C3%A3-et-s-disease
#12
REVIEW
Caroline A Nelson, Sasha Stephen, Hovik J Ashchyan, William D James, Robert G Micheletti, Misha Rosenbach
Neutrophilic dermatoses are a heterogeneous group of inflammatory skin disorders that present with unique clinical features, but are unified by the presence of a sterile, predominantly neutrophilic infiltrate on histopathology. The morphology of cutaneous lesions associated with these disorders is heterogeneous, which renders diagnosis challenging. Moreover, a thorough evaluation is required to exclude diseases that mimic these disorders and to diagnose potential associated infectious, inflammatory, and neoplastic processes...
April 10, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29599340/myelodysplastic-syndrome-and-sweet-s-syndrome-are-associated-with-a-mutation-in-isocitrate-dehydrogenase-1
#13
Rose Snyder, Tiffany Libby, Patricia Raciti, Bijal Amin, Mark Jacobson, Dinesh Rakheja, Kirsten Fleming, Matthias Bartenstein, Changcheng Zhu, Swati Goel, Amit K Verma, Aditi Shastri
BACKGROUND: Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 (IDH1) gene, which causes DNA hypermethylation and alteration of a number of genes that lead to leukemogenesis. However, the pathogenesis of malignancy-associated SS is unknown...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29574433/concurrent-sweet-s-syndrome-and-myopericarditis-following-mesalamine-therapy
#14
Samuel A Shabtaie, Nicholas Y Tan, Riddhi S Parikh, Konstantinos A Papadakis
Mesalamine, or 5-aminosalicylic acid, is a frequently used medication for the treatment of inflammatory bowel disease (IBD). We report the case of a 40-year-old woman recently diagnosed with IBD and started on mesalamine, who presented with new onset tender skin lesions 3 days following medication administration. One day following the onset of skin lesions, the patient developed acute chest pain, shortness of breath, ECG changes, troponemia, C-reactive protein elevation and pericardial enhancement on cardiac MRI consistent with myopericarditis...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29556590/the-role-of-vascular-laboratory-in-the-management-of-eagle-syndrome
#15
Prince C Esiobu, Mi Jin Yoo, Erin M Kirkham, R Eugene Zierler, Benjamin W Starnes, Matthew P Sweet
Eagle syndrome is caused by an elongated styloid process or calcified stylohyoid ligament. The stylocarotid variant with neurologic symptoms is rare and presents a diagnostic challenge. Patients may present with transient ischemic attacks, syncope, or less well defined symptoms like episodic dizziness. We report use of vascular laboratory testing in the management of Eagle syndrome. In one patient, on Doppler ultrasound examination of the ipsilateral temporal artery, the signal was lost with provocative neck flexion...
March 2018: Journal of Vascular Surgery Cases and Innovative Techniques
https://www.readbyqxmd.com/read/29538086/drug-induced-sweet-syndrome-in-a-man-with-sarcoidosis-are-there-any-common-mechanisms-of-pathogenesis
#16
Elena Gkrouzman, Lisa Chirch, Santhanam Lakshminarayanan
No abstract text is available yet for this article.
March 13, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29527024/cutaneous-adverse-reactions-of-chemotherapy-in-cancer-patients-a-clinicoepidemiological-study
#17
Saumita Ghosh Biswal, Rajesh Datt Mehta
Background: The diagnosis of cutaneous adversities in the cancer patient is especially difficult, given the complexity of their illness and combination protocols used for the treatment. The present study was undertaken to know the spectrum of cutaneous adversities in patients undergoing chemotherapy and the drug(s) most commonly associated with it. Materials and Methods: A total of 1000 patients with malignancies under chemotherapy in the oncology ward and outpatient department were screened in this observational study from January 2013 to February 2015...
January 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29516895/reactive-perforating-leprosy-erythema-multiforme-like-reactions-sweet-s-syndrome-like-reactions-as-atypical-clinical-manifestations-of-type-2-leprosy-reaction
#18
Hendra Gunawan, Yuri Yogya, Risty Hafinah, Rachel Marsella, Devi Ermawaty, Oki Suwarsa
Type 2 leprosy reactions commonly known as erythema nodosum leprosum, but various clinical manifestations of type 2 leprosy reaction were exist. The highlight of this case series was to report various atypical clinical manifestations of type 2 leprosy reaction such as reactive perforating leprosy, erythema multiforme-like reaction, and sweet's syndrome (SS)-like reaction.
January 2018: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/29486570/sweet-syndrome-as-the-leading-symptom-in-the-diagnosis-of-gastric-cancer
#19
Alberto Jacobo Cunquero-Tomás, Jose María Ortiz-Salvador, Vega Iranzo, Carlos Camps
Sweet syndrome is a neutrophilic infiltration of the papillary dermis, which may be associated with the presence of unknown malignancies, either haematological or solid tumours, in 1 out of 5 cases, being considered then as a paraneoplastic syndrome. We present the case of a male with a locally advanced gastric cancer whose final diagnosis was led by the prior debut of Sweet syndrome not explained by other causes.
February 2018: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29483999/sweet-s-syndrome-ss-in-the-course-of-acute-myeloid-leukaemia-aml
#20
Claudio Guarneri, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Ilia Lozev, Serena Gianfaldoni, Ivan Pidakev, Jacopo Lotti, Georgi Tchernev
Firstly described by Robert Douglas Sweet in 1964, febrile neutrophilic dermatosis is a disabling, not only cutaneous disorder, clinically characterised by fever and painful erythematous nodules, with a typical background of neutrophilia. Sweet's syndrome (SS) is a chronic inflammatory reactive disorder of unknown cause and incompletely established pathogenesis, although an interplay between genetic and environmental factors, including infections, is likely to occur. A significant part of cases has been demonstrated to be linked with malignancies, especially in the hematologic setting...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
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