Hui Yu, Wenyong Yang, Min Cao, Qingqiang Lei, Renbin Yuan, He Xu, Yuqian Cui, Xuerui Chen, Xu Su, Hui Zhuo, Liangbin Lin
T cells play critical role in multiple immune processes including antigen response, tumor immunity, inflammation, self-tolerance maintenance and autoimmune diseases et. Fetal liver or bone marrow-derived thymus-seeding progenitors (TSPs) settle in thymus and undergo T cell-lineage commitment, proliferation, T cell receptor (TCR) rearrangement, and thymic selections driven by microenvironment composed of thymic epithelial cells (TEC), dendritic cells (DC), macrophage and B cells, thus generating T cells with diverse TCR repertoire immunocompetent but not self-reactive...
2024: Frontiers in Immunology