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https://www.readbyqxmd.com/read/29444704/hpmsc-transplantation-restoring-ovarian-function-in-premature-ovarian-failure-mice-is-associated-with-change-of-th17-tc17-and-th17-treg-cell-ratios-through-the-pi3k-akt-signal-pathway
#1
Na Yin, Yanlin Wang, Xueyan Lu, Ranran Liu, Lianshuang Zhang, Wei Zhao, Wendan Yuan, Qianqian Luo, Hao Wu, Xiying Luan, Hongqin Zhang
BACKGROUND: Human placenta-derived mesenchymal stem cell (hPMSC) transplantation has been demonstrated to be an effective way of recovering ovarian function in mice with autoimmune induced premature ovarian failure (POF). But the exact mechanism remains unclear. The goal of the present study is to investigate the role of immune factors (T-helper 17 (Th17), cytotoxic T (Tc17) and regulatory T (Treg) cells) in the recovery of ovarian function and whether the phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway is involved in the regulation...
February 14, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29414833/increased-proportion-of-tc17-and-th17-cells-and-their-significant-reduction-after-thymectomy-may-be-related-to-disease-progression-in-myasthenia-gravis
#2
Mina Hosseini, Behrouz Robat-Jazi, Vahid Shaygannejad, Shahriar Naffisi, Omid Mirmossayeb, Abbas Rezaei, Marjan Mansourian, Nafiseh Esmaeil
OBJECTIVE: Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies against the neuromuscular junction. The thymus has an important role in the pathogenesis of MG because most patients have thymic pathology, and thymectomy (TE) can reduce the severity of the disease. METHODS: In this study, the frequency of Th17 and Tc17 cells was studied in 12 MG patients (pre-TE and 6 months post-TE) and in 12 healthy controls (HC). RESULTS: The frequency of Tc17 cells in the pre-TE patients was significantly higher than in the HC (p < 0...
February 8, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29396902/differentiation-of-mscs-from-human-ipscs-results-in-downregulation-of-c-myc-dna-replication-pathways-with-immunomodulation-toward-cd4-cd8-cells
#3
Li-Tzu Wang, Shih-Sheng Jiang, Chiao-Hsuan Ting, Pei-Ju Hsu, Chia-Chi Chang, Huey-Kang Sytwu, Ko-Jiunn Liu, B Linju Yen
Multilineage tissue-source mesenchymal stem cells (MSCs) possess strong immunomodulatory properties and are excellent therapeutic agents, but require constant isolation from donors to combat replicative senescence. The differentiation of human induced pluripotent stem cells (iPSCs) into MSCs offers a renewable source of MSCs; however, reports on their immunomodulatory capacity have been discrepant. Using MSCs differentiated from iPSCs reprogrammed using diverse cell types and protocols, and in comparison to human embryonic stem cell (ESC)-MSCs and bone marrow (BM)-MSCs, we performed transcriptome analyses and assessed for functional immunomodulatory properties...
February 3, 2018: Stem Cells
https://www.readbyqxmd.com/read/29378910/mucosal-associated-invariant-t-cells-augment-immunopathology-and-gastritis-in-chronic-helicobacter-pylori-infection
#4
Criselle D'Souza, Troi Pediongco, Huimeng Wang, Jean-Pierre Y Scheerlinck, Lyudmila Kostenko, Robyn Esterbauer, Andrew W Stent, Sidonia B G Eckle, Bronwyn S Meehan, Richard A Strugnell, Hanwei Cao, Ligong Liu, Jeffrey Y W Mak, George Lovrecz, Louis Lu, David P Fairlie, Jamie Rossjohn, James McCluskey, Alison L Every, Zhenjun Chen, Alexandra J Corbett
Mucosal-associated invariant T (MAIT) cells produce inflammatory cytokines and cytotoxic granzymes in response to by-products of microbial riboflavin synthesis. Although MAIT cells are protective against some pathogens, we reasoned that they might contribute to pathology in chronic bacterial infection. We observed MAIT cells in proximity to Helicobacter pylori bacteria in human gastric tissue, and so, using MR1-tetramers, we examined whether MAIT cells contribute to chronic gastritis in a mouse H. pylori SS1 infection model...
January 29, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29369782/pharmacological-inhibitory-profile-of-tak-828f-a-potent-and-selective-orally-available-ror%C3%AE-t-inverse-agonist
#5
Akira Shibata, Keiko Uga, Takayuki Sato, Masaki Sagara, Keiko Igaki, Yoshiki Nakamura, Atsuko Ochida, Mitsunori Kono, Junya Shirai, Satoshi Yamamoto, Masashi Yamasaki, Noboru Tsuchimori
Retinoic acid-related orphan receptor γt (RORγt) is a key master regulator of the differentiation and activation of IL-17 producing CD4+ Th17, CD8+ Tc17 and IL-17/IFN-γ co-producing cells (Th1/17 cells). These cells play critical roles in the pathogenesis of autoimmune diseases such as inflammatory bowel disease and multiple sclerosis. Thus, RORγt is an attractive target for the treatment of these diseases. We discovered TAK-828F, an orally available potent and selective RORγt inverse agonist. The inhibitory effect on the activation and differentiation of Th17 cells by TAK-828F was evaluated in mouse and human primary cells...
January 21, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29205464/interleukin-17-family-cytokines-in-protective-immunity-against-infections-role-of-hematopoietic-cell-derived-and-non-hematopoietic-cell-derived-interleukin-17s
#6
REVIEW
Goro Matsuzaki, Masayuki Umemura
Interleukin (IL)-17 family cytokines consisting of six members participate in immune response in infections, autoimmune diseases and inflammatory diseases. The prototype cytokine of the family, IL-17A, was originally identified from CD4+ T cells which are now termed Th17. Later IL-17A-producing cells are expanded to various hematopoietic cells including CD8+ T cells (Tc17), invariant NKT cells, γ δ T cells, non-T non-B lymphocytes termed type 3 innate lymphoid cells (ILC3), and neutrophils. Some members of the IL-17 family cytokines other than IL-17A were also expressed by CD4+ T cells: IL-17E by Th2 cells, and IL-17F by Th17 cells...
December 2, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29187586/live-attenuated-leishmania-donovani-centrin-gene-deleted-parasites-induce-il-23-dependent-il-17-protective-immune-response-against-visceral-leishmaniasis-in-a-murine-model
#7
Antara Banerjee, Parna Bhattacharya, Pradeep K Dagur, Subir Karmakar, Nevien Ismail, Amritanshu B Joshi, Adovi D Akue, Mark KuKuruga, John Philip McCoy, Ranadhir Dey, Hira L Nakhasi
No vaccine exists against visceral leishmaniasis. To develop effective vaccines, we have previously reported protective role of live attenuated centrin gene-deleted Leishmania donovani (LdCen-/- ) parasites through induction of Th1 type immune response in mice, hamsters, and dogs. In this study, we specifically explored the role of Th17 cells in LdCen-/- -induced host protection in mice. Our results showed that compared with wild-type L. donovani infection, LdCen-/- parasites induce significantly higher expression of Th17 differentiation cytokines in splenic dendritic cells...
November 29, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29180433/a-stat3-dependent-transcriptional-circuitry-inhibits-cytotoxic-gene-expression-in-t-cells
#8
Thomas Ciucci, Melanie S Vacchio, Rémy Bosselut
CD8+ T cells are preprogrammed for cytotoxic differentiation in the thymus as they acquire expression of the transcription factor Runx3. However, a subset of effector CD8+ T cells (Tc17) produce IL-17 and fail to express cytotoxic genes. Here, we show that the transcription factors directing IL-17 production, STAT3 and RORγt, inhibit cytotoxicity despite persistent Runx3 expression. Cytotoxic gene repression did not require the transcription factor Thpok, which in CD4+ T cells restrains Runx3 functions and cytotoxicity; and STAT3 restrained cytotoxic gene expression in CD8+ T cells responding to viral infection in vivo...
November 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29175506/cd26-expression-is-down-regulated-on-cd8-t-cells-in-patients-with-hashimoto-s-thyroiditis
#9
Yalei Liu, Yuan Li, Yan Gong, Nan Yu, Yang Zhang, Ran You, Chenxue Qu, Guizhi Lu, Youyuan Huang, Ying Gao, Yanming Gao, Xiaohui Guo
The immune mechanism underlying Hashimoto's thyroiditis (HT) remains unclear. CD26, also known as dipeptidyl peptidase 4 (DPP-4), is a multifunctional molecule involved in the pathophysiology of autoimmune diseases. This study aimed to investigate the role of CD26 in the pathogenesis of HT. Peripheral blood was drawn from 20 healthy controls and 31 HT patients (19 mild HT patients and 12 severe HT patients). Plasma sCD26 concentrations were measured by ELISA, and sCD26 enzymatic activity was assessed using a luciferase-based assay...
November 23, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29108201/-clinical-features-of-imbalance-between-th1-and-th22-cells-and-its-association-with-disease-progression-in-patients-with-liver-cirrhosis
#10
H Q Wu, J J Zhao, H W Li, Z Zhang
Objective: To investigate the clinical features of imbalance between Th1 and Th22 cells and its association with disease progression in patients with liver cirrhosis, and to explore immune therapeutic strategies for targeted therapy for liver cirrhosis. Methods: In vitro peripheral blood mononucleated cells (PBMCs) were collected by centrifugation. CD3-BV500 and CD8-PerCP-Cy5.5 staining was performed for these cells. IFNγ-PE-Cy7, IL-17a-APC, IL-22-PE, or the corresponding isotype control was added, and then PBMCs were fixed with 1% polyoxymethylene after being washed once by permeabilization-wash buffer...
October 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29054368/an-intermediate-level-of-cd161-expression-defines-a-novel-activated-inflammatory-and-pathogenic-subset-of-cd8-t-cells-involved-in-multiple-sclerosis
#11
Bryan Nicol, Marion Salou, Isabel Vogel, Alexandra Garcia, Emilie Dugast, Jeremy Morille, Stéphanie Kilens, Eric Charpentier, Audrey Donnart, Steven Nedellec, Marylène Jacq-Foucher, Fabienne Le Frère, Sandrine Wiertlewski, Arnaud Bourreille, Sophie Brouard, Laure Michel, Laurent David, Pierre-Antoine Gourraud, Nicolas Degauque, Arnaud B Nicot, Laureline Berthelot, David-Axel Laplaud
Several lines of evidence support a key role for CD8(+) T cells in central nervous system tissue damage of patients with multiple sclerosis. However, the precise phenotype of the circulating CD8(+) T cells that may be recruited from the peripheral blood to invade the CNS remains largely undefined to date. It has been suggested that IL-17 secreting CD8 (Tc17) T cells may be involved, and in humans these cells are characterized by the expression of CD161. We focused our study on a unique and recently described subset of CD8 T cells characterized by an intermediate expression of CD161 as its role in neuroinflammation has not been investigated to date...
October 17, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29033080/reconstitution-of-th17-tc17-and-treg-cells-after-paediatric-haematopoietic-stem-cell-transplantation-impact-of-interleukin-7
#12
Katrine Kielsen, Lars P Ryder, David Lennox-Hvenekilde, Monika Gad, Claus H Nielsen, Carsten Heilmann, Marianne Ifversen, Anders Elm Pedersen, Klaus Müller
Successful reconstitution of T lymphocytes after allogeneic haematopoietic stem cell transplantation (HSCT) is needed to establish the graft-versus-leukaemia effect and an effective anti-microbial defense, but the ratio between functionally different T-cell subsets needs to be balanced to avoid graft-versus-host disease (GVHD). IL-7 is essential for T-cell generation in the thymus and peripheral T-cell homeostasis. High IL-7 levels have been associated with impaired T-cell reconstitution, increased risk of acute GVHD and treatment-related mortality, but the underlying cellular mechanisms behind these associations have not been investigated previously...
October 9, 2017: Immunobiology
https://www.readbyqxmd.com/read/28931653/combined-ox40l-and-mtor-blockade-controls-effector-t-cell-activation-while-preserving-treg-reconstitution-after-transplant
#13
Victor Tkachev, Scott N Furlan, Benjamin Watkins, Daniel J Hunt, Hengqi Betty Zheng, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, John B Schell, Katie Zeleski, Alison Yu, Ian Kirby, Sarah Cooley, Jeffrey S Miller, Bruce R Blazar, Duncan Casson, Phil Bland-Ward, Leslie S Kean
A critical question facing the field of transplantation is how to control effector T cell (Teff) activation while preserving regulatory T cell (Treg) function. Standard calcineurin inhibitor-based strategies can partially control Teffs, but breakthrough activation still occurs, and these agents are antagonistic to Treg function. Conversely, mechanistic target of rapamycin (mTOR) inhibition with sirolimus is more Treg-compatible but is inadequate to fully control Teff activation. In contrast, blockade of OX40L signaling has the capacity to partially control Teff activation despite maintaining Treg function...
September 20, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28900479/loss-of-tff1-promotes-pro-inflammatory-phenotype-with-increase-in-the-levels-of-ror%C3%AE-t-t-lymphocytes-and-il-17-in-mouse-gastric-neoplasia
#14
Mohammed Soutto, Mohamed Saleh, Mohamed S Arredouani, Blanca Piazuelo, Abbes Belkhiri, Wael El-Rifai
Background: TFF1 deficiency induces a mucosal pro-inflammatory phenotype that contributes to gastric tumorigenesis in mouse and human. Methods: We utilized the Tff1-KO mouse model to assess the impact of TFF1 loss on immune cells infiltration in the stomach. We used single cell suspension, flow cytometry, immunohistochemistry, and quantitative PCR (qPCR) assays. Results: The Tff1-KO gastric mucosa demonstrated high chronic inflammatory scores (score: 3-4) at age 2 months, which exacerbated at age 8 months (score: 4-6)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28874444/modulation-of-cd4-and-cd8-t-cell-function-and-cytokine-responses-in-strongyloides-stercoralis-infection-by-interleukin-27-il-27-and-il-37
#15
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Chandrakumar Dolla, Paul Kumaran, Thomas B Nutman, Subash Babu
Strongyloides stercoralis infection is associated with diminished antigen-specific Th1- and Th17-associated responses and enhanced Th2-associated responses. Interleukin-27 (IL-27) and IL-37 are two known anti-inflammatory cytokines that are highly expressed in S. stercoralis infection. We therefore wanted to examine the role of IL-27 and IL-37 in regulating CD4(+) and CD8(+) T cell responses in S. stercoralis infection. To this end, we examined the frequency of Th1/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, and Th22/Tc22 cells in 15 S...
November 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28757467/high-level-expression-and-purification-of-soluble-form-of-human-natural-killer-cell-receptor-nkr-p1-in-hek293s-gnti-cells
#16
Jan Bláha, Barbora Kalousková, Ondřej Skořepa, Samuel Pažický, Petr Novák, Ondřej Vaněk
Human natural killer receptor protein 1 (NKR-P1, CD161, gene klrb1) is a C-type lectin-like receptor of natural killer (NK) cells responsible for recognition of its cognate protein ligand lectin-like transcript 1 (LLT1). NKR-P1 is the single human orthologue of the prototypical rodent NKR-P1 receptors. Naturally, human NKR-P1 is expressed on the surface of NK cells, where it serves as inhibitory receptor; and on T and NKT cells functioning as co-stimulatory receptor promoting secretion of IFNγ. Most notably, it is expressed on Th17 and Tc17 lymphocytes where presumably promotes targeting into LLT1 expressing immunologically privileged niches...
December 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28741316/role-of-cd4-t-cell-helper-subsets-in-immune-response-and-deviation-of-cd8-t-cells-in-mice
#17
Alison Hogg, Yongjun Sui, Shlomo Z Ben-Sasson, William E Paul, Jay A Berzofsky
The ability of different CD4(+) T cell subsets to help CD8(+) T-cell response is not fully understood. Here, we found using the murine system that Th17 cells induced by IL-1β, unlike Th1, were not effective helpers for antiviral CD8 responses as measured by IFNγ-producing cells or protection against virus infection. However, they skewed CD8 responses to a Tc17 phenotype. Thus, the apparent lack of help was actually immune deviation. This skewing depended on both IL-21 and IL-23. To overcome this effect, we inhibited Th17 induction by blocking TGF-β...
July 24, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28665747/analysis-of-immunological-mechanisms-exerted-by-hbsag-hbig-therapeutic-vaccine-combined-with-adefovir-in-chronic-hepatitis-b-patients
#18
Chenliang Zhou, Chaofan Li, Guo-Zhong Gong, Shuang Wang, Ji-Ming Zhang, Dao-Zhen Xu, Li-Min Guo, Hong Ren, Min Xu, Qing Xie, Chen Pan, Jie Xu, Zhongyu Hu, Shuang Geng, Xian Zhou, Xianzheng Wang, Xiaoyu Zhou, Haili Mi, Gan Zhao, Wencong Yu, Yu-Mei Wen, Lihua Huang, Xuan-Yi Wang, Bin Wang
An HBsAg-HBIG therapeutic vaccine (Yeast-derived Immune Complexes, YIC) for chronic hepatitis B (CHB) patients has undergone a series of clinical trials. The HBeAg sero-conversion rate of YIC varied from 21.9% to 14% depending on the immunization protocols from 6 to 12 injections. To analyze the immunological mechanisms exerted by 6 injections of YIC, 44 CHB patients were separately immunized with YIC, alum as adjuvant control or normal saline as blank control, with add on of antiviral drug Adefovir in all groups...
September 2, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28597107/microscopic-colitis-evolved-into-inflammatory-bowel-diseases-is-characterized-by-increased-th1-tc1-cells-in-colonic-mucosal-lamina-propria
#19
Ji Li, Yuchu Yan, Ziran Meng, Shuhong Liu, Paul L Beck, Subrata Ghosh, Jiaming Qian, Xianyong Gui
BACKGROUND: An association between microscopic colitis (MC), i.e., lymphocytic colitis (LC) and collagenous colitis (CC), and inflammatory bowel diseases (IBD) has been noticed. A subset of MC cases may evolve into IBD, and IBD in remission may present as MC in a histologic pattern. Moreover, MC and IBD may coexist in different regions of the bowel. A link between MC and IBD in their pathogenesis is, therefore, suggested. Abnormal mucosal immunity is likely the key. METHODS: We reviewed 2324 MC cases in Calgary over 14 years and identified 20 cases evolved into IBD (IBD transformers)...
October 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28558065/prediabetes-is-associated-with-the-modulation-of-antigen-specific-th1-tc1-and-th17-tc17-responses-in-latent-mycobacterium-tuberculosis-infection
#20
Nathella Pavan Kumar, Kadar Moideen, Chandrakumar Dolla, Paul Kumaran, Subash Babu
Type 2 diabetes mellitus (DM) is associated with the down modulation of Th1, Th2 and Th17 responses in latent Mycobacterium tuberculosis infection but the role of prediabetes (PDM) in this setting is not well understood. To examine the role of CD4+ and CD8+ T cell cytokines in latent tuberculosis (LTB) with coincident PDM, we studied the baseline, mycobacterial, control antigen and mitogen-stimulated T cell cytokine responses in LTB individuals with (LTB-PDM; n = 20) or without (LTB-NDM; n = 20) concomitant prediabetes...
2017: PloS One
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