Criselle D'Souza, Troi Pediongco, Huimeng Wang, Jean-Pierre Y Scheerlinck, Lyudmila Kostenko, Robyn Esterbauer, Andrew W Stent, Sidonia B G Eckle, Bronwyn S Meehan, Richard A Strugnell, Hanwei Cao, Ligong Liu, Jeffrey Y W Mak, George Lovrecz, Louis Lu, David P Fairlie, Jamie Rossjohn, James McCluskey, Alison L Every, Zhenjun Chen, Alexandra J Corbett
Mucosal-associated invariant T (MAIT) cells produce inflammatory cytokines and cytotoxic granzymes in response to by-products of microbial riboflavin synthesis. Although MAIT cells are protective against some pathogens, we reasoned that they might contribute to pathology in chronic bacterial infection. We observed MAIT cells in proximity to Helicobacter pylori bacteria in human gastric tissue, and so, using MR1-tetramers, we examined whether MAIT cells contribute to chronic gastritis in a mouse H. pylori SS1 infection model...
January 29, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists