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https://www.readbyqxmd.com/read/28549089/development-of-a-sustained-release-voriconazole-containing-thermogel-for-subconjunctival-injection-in-horses
#1
Rosemary S Cuming, Eva M Abarca, Sue Duran, Anne A Wooldridge, Allison J Stewart, William Ravis, R Jayachandra Babu, Yuh-Jing Lin, Terri Hathcock
Purpose: To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods: In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined for 28 days. A Franz cell diffusion chamber was used to evaluate equine transcorneal and transscleral permeation of voriconazole (1...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28548837/the-role-of-the-hydroxyl-group-in-propofol-protein-target-recognition-insights-from-oniom-studies
#2
Ling Qiu, Jianguo Lin, Qingzhu Liu, Shanshan Wang, Gaochao Lv, Ke Li, Haiming Shi, Zhengkun Huang, Edward J Bertaccini
Propofol (PFL, 1-hydroxyl-2,6-diisopropylbenzene) is currently used widely as one of the most well-known intravenous anesthetics to relieve surgical suffering, but its mechanism of action is not yet clear. Previous experimental studies have demonstrated that the hydroxyl group of PFL plays a dominant role in the molecular recognition of PFL with receptors that lead to hypnosis. To further explore the mechanism of anesthesia induced by PFL in the present work, the exact binding features and interaction details of PFL with three important proteins, human serum albumin (HSA), the pH-gated ion channel from Gloeobacter violaceus (GLIC) and horse spleen apoferritin (HSAF), were investigated systematically by using a rigorous three-layer ONIOM(M06-2X/6-31+G*:PM6:AMBER) method...
May 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28548826/protein-nanocage-based-photo-controlled-nitric-oxide-releasing-platform
#3
Xiao Li, Yajie Zhang, Jian Sun, Weijian Chen, Xuewei Wang, Fenli Shao, Yuyu Zhu, Fude Feng, Yang Sun
A photoactive NO releasing system was constructed by incorporation of NO-bound Fe-S clusters into horse spleen apoferritin cavities with high loading efficacy. The composites retained intact core-shell structure and indicated advantages such as enhanced stability, reduced cytotoxicity, efficient cellular uptake, and photo-controlled NO releasing property.
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28548349/head-withers-and-pelvic-movement-asymmetry-and-their-relative-timing-in-trot-in-racing-thoroughbreds-in-training
#4
T Pfau, K Noordwijk, M F Sepulveda Caviedes, E Persson-Sjodin, A Barstow, B Forbes, M Rhodin
BACKGROUND: Horses show compensatory head movement in hindlimb lameness and compensatory pelvis movement in forelimb lameness but little is known about the relationship of withers movement symmetry with head and pelvic asymmetry in horses with naturally occurring gait asymmetries. Objectives To document head, withers and pelvic movement asymmetry and timing differences in horses with naturally occurring gait asymmetries. STUDY DESIGN: Retrospective analysis of gait data...
May 26, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28547914/the-branching-pattern-of-the-brachiocephalic-trunk-in-the-donkey-equus-asinus
#5
G Akbari, B Asadiahranjani, N Goodarzi, S Shokrollahi
Donkeys are a member of the horse family (Equidae) and share a common ancestor. However, in morphological terms, donkeys and horses are regarded as two separate subgenus. Given variations in the branching pattern of the brachiocephalic trunk (BCT) in different species of animals and the use of donkeys in anatomy courses at colleges of veterinary medicine, we conducted this study in order to investigate the branching patterns of BCT and to describe detailed morphological information regarding donkeys. Seventeen mature donkeys were examined following euthanasia by exsanguination from the common carotid artery under general anaesthesia...
May 26, 2017: Anatomia, Histologia, Embryologia
https://www.readbyqxmd.com/read/28545825/the-effect-of-anesthetic-drug-choice-on-accuracy-of-high-definition-oscillometry-in-laterally-recumbent-horses
#6
Tanya Duke-Novakovski, Barbara Ambros, Cindy Feng, Anthony P Carr
OBJECTIVE: To determine the accuracy of high-definition oscillometry (HDO) for arterial pressure measurement during injectable or inhalation anesthesia in horses. STUDY DESIGN: Prospective, clinical study. ANIMALS: Twenty-four horses anesthetized for procedures requiring lateral recumbency. METHODS: Horses were premedicated with xylazine, and anesthesia induced with diazepam-ketamine. Anesthesia was maintained with xylazine-ketamine-guaifenesin combination [TripleDrip (TD; n = 12) or isoflurane (ISO; n = 12)]...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28545510/effect-of-bone-marrow-derived-mesenchymal-stem-cells-and-stem-cell-supernatant-on-equine-corneal-wound-healing-in-vitro
#7
Amanda B Sherman, Brian C Gilger, Alix K Berglund, Lauren V Schnabel
BACKGROUND: We aimed to determine and compare the in vitro effects of autologous bone marrow-derived mesenchymal stem cells (BM-MSCs) and mesenchymal stem cell supernatant (MSC-Sp) on the wound healing capacity of equine corneal fibroblasts using a scratch assay. METHODS: Bone marrow aspirates and eyes were collected from normal, euthanized horses with subsequent isolation and culture of BM-MSCs and corneal stromal cells. Corneal stromal cells were culture-expanded in the culture well of transwell plates and then treated with an autologous BM-MSC suspension (dose: 2...
May 25, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28545325/mandibular-odontoameloblastoma-in-a-rat-and-a-horse
#8
Brian Murphy, Cynthia Bell, Amanda Koehne, Richard R Dubielzig
Odontoameloblastoma (OA) is a mixed odontogenic tumor that is an ameloblastoma with concurrent histologic evidence of odontoma differentiation. As a mixed tumor, OA is a tripartite lesion comprised of neoplastic odontogenic epithelium, induced dental ectomesenchyme (dental pulp), and mineralized dental matrix. Although rare, OA represents a diagnostic conundrum, as it is histologically closely related to 2 other mixed odontogenic tumors: odontoma (complex and compound) and ameloblastic fibro-odontoma. Herein we describe an OA arising from the mandible of a 4-mo-old Fischer 344 rat that had been exposed in utero to the mutagen ENU (N-ethyl-N-nitrosourea), and a naturally occurring lesion in a 2-y-old Appaloosa horse...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28544084/what-is-your-diagnosis-blood-smear-from-a-horse
#9
Katie M Boes, Nicole M Weinstein
No abstract text is available yet for this article.
May 19, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28543943/assessment-of-horse-owners-ability-to-recognise-equine-laminitis-a-cross-sectional-study-of-93-veterinary-diagnosed-cases-in-great-britain
#10
D Pollard, C E Wylie, K L P Verheyen, J R Newton
BACKGROUND: Use of owner-reported data could further epidemiological knowledge of equine laminitis. However, owner recognition of laminitis has not previously been assessed. OBJECTIVES: The primary objective was to establish whether cases of owner-suspected laminitis would be confirmed as laminitis by the attending veterinary surgeon. Secondary objectives were to compare owner- and veterinary-reported information from veterinary-confirmed cases of equine laminitis...
May 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28543933/repeatability-of-oral-sugar-test-results-glucagon-like-peptide-1-measurements-and-serum-high-molecular-weight-adiponectin-concentrations-in-horses
#11
N Frank, D M Walsh
BACKGROUND: Repeatability of the oral sugar test (OST) has not been evaluated. OBJECTIVES: We hypothesized that OST glucose, insulin, active (aGLP-1) and total (tGLP-1) glucagon-like peptide 1, and high-molecular-weight (HMW) adiponectin results would be repeatable. ANIMALS: Fifty-three horses from a Tennessee research facility (n = 23) and private practice in Missouri (n = 30), including animals with medical histories of equine metabolic syndrome...
May 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28543538/clinical-and-histopathological-features-of-myofibrillar-myopathy-in-warmblood-horses
#12
S J Valberg, A M Nicholson, S S Lewis, R A Reardon, C J Finno
BACKGROUND: To report a novel exertional myopathy, myofibrillar myopathy (MFM), in Warmblood horses. OBJECTIVES: To 1) describe the distinctive clinical and myopathic features of MFM in Warmblood horses, 2) investigate the potential inheritance of MFM in a Warmblood family. STUDY DESIGN: Retrospective selection of MFM cases and prospective evaluation of a Warmblood family. METHODS: Retrospectively, muscle biopsies were selected from Warmblood horses diagnosed with MFM and clinical histories obtained (n = 10)...
May 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28543410/the-diagnosis-of-equine-insulin-dysregulation
#13
REVIEW
F R Bertin, M A de Laat
Insulin dysregulation is the hallmark of Equine Metabolic Syndrome and has received attention because of its direct association with laminitis. In the absence of an adequate treatment for laminitis, a focus on prophylaxis is needed, making early detection of individuals at risk of developing laminitis one of the main challenges in equine endocrinology. Recent studies have shown that insulin dysregulation goes beyond tissue insulin resistance and it is now demonstrated that the equine enteroinsular axis plays a major role in insulin secretion and equine hyperinsulinaemia...
May 22, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28542897/osteoarthritis-in-two-marine-mammals-and-22-land-mammals-learning-from-skeletal-remains
#14
Korakot Nganvongpanit, Ratsadakorn Soponteerakul, Piyatida Kaewkumpai, Veerasak Punyapornwithaya, Kittisak Buddhachat, Raksiri Nomsiri, Patcharaporn Kaewmong, Kongkiat Kittiwatanawong, Rachanchai Chawangwongsanukun, Taweepoke Angkawanish, Chatchote Thitaram, Pasuk Mahakkanukrauh
The occurrence of osteoarthritis (OA) in marine mammals is still questionable. Here we investigated the prevalence of OA in marine (dolphin and dugong) and terrestrial mammals (Asian elephant, Asiatic buffalo, camel, cat, cattle, deer, dog, domestic goat, horse, human, hyena, impala, lion, Malayan tapir, Assam macaque, mule, pig, rabbit, red kangaroo, sheep, tiger and waterbuck). Skeletal remains obtained from five institutes were used as subjects; a total of 45 different parts (locations) of bones were observed for OA lesions...
May 23, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28542345/ancient-mtdna-diversity-reveals-specific-population-development-of-wild-horses-in-switzerland-after-the-last-glacial-maximum
#15
Julia Elsner, Michael Hofreiter, Jörg Schibler, Angela Schlumbaum
On large geographical scales, changes in animal population distribution and abundance are driven by environmental change due to climatic and anthropogenic processes. However, so far, little is known about population dynamics on a regional scale. We have investigated 92 archaeological horse remains from nine sites mainly adjacent to the Swiss Jura Mountains dating from c. 41,000-5,000 years BP. The time frame includes major environmental turning points such as the Last Glacial Maximum (LGM), followed by steppe vegetation, afforestation and initial re-opening of the landscape by human agricultural activities...
2017: PloS One
https://www.readbyqxmd.com/read/28542310/geographic-distribution-of-angiostrongylus-cantonensis-in-wild-rats-rattus-rattus-and-terrestrial-snails-in-florida-usa
#16
Heather D Stockdale Walden, John D Slapcinsky, Shannon Roff, Jorge Mendieta Calle, Zakia Diaz Goodwin, Jere Stern, Rachel Corlett, Julia Conway, Antoinette McIntosh
The parasitic nematode Angiostrongylus cantonensis is a major cause of eosinophilic meningitis in humans, and has been documented in other incidental hosts such as birds, horses, dogs and non-human primates. It is endemic in Hawaii, and there have been sporadic reports in the southern continental United States. This parasite uses rats as definitive hosts and snails as intermediate hosts. In this study, we collected potential definitive and intermediate hosts throughout Florida to ascertain the geographic distribution in the state: Rats, environmental rat fecal samples, and snails were collected from 18 counties throughout the state...
2017: PloS One
https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#17
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28541154/assessment-of-agreement-among-diplomates-of-the-american-college-of-veterinary-anesthesia-and-analgesia-for-scoring-the-recovery-of-horses-from-anesthesia-by-use-of-subjective-grading-scales-and-development-of-a-system-for-evaluation-of-the-recovery-of-horses
#18
Stuart C Clark-Price, Kara M Lascola, Jennifer E Carter, Anderson F da Cunha, Lydia L Donaldson, Thomas J Doherty, Manuel Martin-Flores, Erik H Hofmeister, Stephanie C J Keating, Khursheed R Mama, Diane E Mason, Lysa P Posner, Hiroki Sano, Reza Seddighi, Andre C Shih, Ann B Weil, David J Schaeffer
OBJECTIVE To evaluate agreement among diplomates of the American College of Veterinary Anesthesia and Analgesia for scores determined by use of a simple descriptive scale (SDS) or a composite grading scale (CGS) for quality of recovery of horses from anesthesia and to investigate use of 3-axis accelerometry (3AA) for objective evaluation of recovery. ANIMALS 12 healthy adult horses. PROCEDURES Horses were fitted with a 3AA device and then were anesthetized. Eight diplomates evaluated recovery by use of an SDS, and 7 other diplomates evaluated recovery by use of a CGS...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28541151/morphological-evaluation-of-merkel-cells-and-small-lamellated-sensory-receptors-in-the-equine-foot
#19
Robert M Bowker, Lisa S Lancaster, Diane A Isbell
OBJECTIVE To examine the equine foot for the presence of sensory receptors including Merkel cells and small lamellated Pacinian-like corpuscles (SLPCs). SAMPLE Forefeet obtained from 7 horses following euthanasia for reasons other than foot disease. PROCEDURES Disarticulated feet were cut into either sagittal sections or cross sections and immersed in neutral-buffered 4% formalin. Following fixation, samples were obtained from the midline of the dorsal aspect of the hoof wall and from the frog (cuneus ungulae) between the apex and central sulcus...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28541149/characterization-of-equine-vitamin-d-binding-protein-development-of-an-assay-and-assessment-of-plasma-concentrations-of-the-protein-in-healthy-horses-and-horses-with-gastrointestinal-disease
#20
Tina H Pihl, Stine Jacobsen, Dorthe T Olsen, Peter Højrup, Astrid Grosche, David E Freeman, Pia H Andersen, Gunnar Houen
OBJECTIVE To purify and characterize equine vitamin D-binding protein (VDBP) from equine serum and to evaluate plasma concentrations of VDBP in healthy horses and horses with gastrointestinal injury or disease. ANIMALS 13 healthy laboratory animals (8 mice and 5 rabbits), 61 healthy horses, 12 horses with experimentally induced intestinal ischemia and reperfusion (IR), and 59 horses with acute gastrointestinal diseases. PROCEDURES VDBP was purified from serum of 2 healthy horses, and recombinant equine VDBP was obtained through a commercial service...
June 2017: American Journal of Veterinary Research
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