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https://www.readbyqxmd.com/read/29790215/attenuated-nitric-oxide-bioavailability-in-systemic-sclerosis-evidence-from-the-novel-assessment-of-passive-leg-movement
#1
Heather L Clifton, Daniel R Machin, H Jonathan Groot, Tracy M Frech, Anthony J Donato, Russell S Richardson, D Walter Wray
NEW FINDINGS: What is the central question of this study? Do systemic sclerosis (SSc) patients exhibit impaired nitric oxide (NO)-mediated vascular function of the lower limb, and are these decrements correlated with plasma biomarkers for inflammation and oxidative stress? What is the main finding and its importance? Findings indicate impaired NO-mediated vascular function, linked to the incidence of digital ulcers, and a milieu of inflammation and oxidative stress. However, the absence of significant correlations between individual biomarkers and blood flow responses suggests the vasculopathy observed in SSc may not be solely the result of derangements in the redox balance or inflammatory signaling...
May 23, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29787366/parasympathetic-activity-increases-with-digital-microvascular-damage-and-vascular-endothelial-growth-factor-in-systemic-sclerosis
#2
Antonietta Gigante, Domenico Margiotta, Luca Navarini, Marta Liberatori, Biagio Barbano, Luigi Tubani, Antonella Afeltra, Edoardo Rosato
OBJECTIVES: The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF). METHODS: Twenty-seven SSc patients were enrolled...
May 11, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29782427/clinical-profile-of-levamisole-adulterated-cocaine-induced-vasculitis-vasculopathy-a-30-case-series
#3
Carlos Horacio Muñoz-Vahos, Sebastián Herrera-Uribe, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González-Naranjo, Gloria Vásquez-Duque, Mauricio Restrepo-Escobar, Luis Alfonso Correa-Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García
OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#4
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781588/smoking-in-systemic-sclerosis-a-longitudinal-european-scleroderma-trials-and-research-group-study
#5
Veronika K Jaeger, Gabriele Valentini, Eric Hachulla, Franco Cozzi, Oliver Distler, Paolo Airó, Laszlo Czirják, Yannick Allanore, Elise Siegert, Edoardo Rosato, Marco Matucci-Cerinic, Cristian Caimmi, Jörg Henes, Patricia E Carreira, Vanessa Smith, Francesco Del Galdo, Christopher P Denton, Susanne Ullman, Ellen De Langhe, Valeria Riccieri, Juan J Alegre-Sancho, Simona Rednic, Ulf Müller-Ladner, Ulrich A Walker
OBJECTIVES: Data on the role of tobacco exposure in systemic sclerosis (SSc) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations in the EUSTAR database. METHODS: Adult SSc patients with data on smoking history and a 12-24 months follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the comprehensive smoking index (CSI) were assessed using multivariable regression analyses...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29781586/treatment-algorithms-for-systemic-sclerosis-according-to-experts
#6
Andreu Fernández-Codina, Kyle M Walker, Janet E Pope
INTRODUCTION: Treatment for many aspects of systemic sclerosis (SSc) lacks agreement. OBJECTIVES: To generate SSc treatment algorithms endorsed by high percentage of SSc experts. METHODS: Experts from the Scleroderma Clinical Trials Consortium and the Canadian Scleroderma Research group (N=170) were asked whether they agreed with SSc algorithms (from 2012). Two consensus rounds refined agreement; 62 (36%), 54 (32%) and 48 (28%) experts completed surveys...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29779008/intervention-planning-for-the-reduce-maintenance-intervention-a-digital-intervention-to-reduce-reulceration-risk-among-patients-with-a-history-of-diabetic-foot-ulcers
#7
Kate Greenwell, Katy Sivyer, Kavita Vedhara, Lucy Yardley, Frances Game, Trudie Chalder, Gayle Richards, Nikki Drake, Katie Gray, John Weinman, Katherine Bradbury
OBJECTIVES: To develop a comprehensive intervention plan for the REDUCE maintenance intervention to support people who have had diabetic foot ulcers (DFUs) to sustain behaviours that reduce reulceration risk. METHODS: Theory-based, evidence-based and person-based approaches to intervention development were used. In phase I of intervention planning, evidence was collated from a scoping review of the literature and qualitative interviews with patients who have had DFUs (n=20)...
May 18, 2018: BMJ Open
https://www.readbyqxmd.com/read/29763902/prognostic-factors-of-renal-involvement-in-systemic-sclerosis
#8
Edoardo Rosato, Antonietta Gigante, Biagio Barbano, Maria Ludovica Gasperini, Rosario Cianci, Maurizio Muscaritoli
BACKGROUND/AIMS: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was to evaluate type and evolution of renal involvement for a period of five years. METHODS: 121 SSc patients (100 F, 21 M) with mean age of 54.9 ± 13.8, disease duration of 9 ± 6 years, of which 62 had a diffused form and 59 limited form were enrolled...
May 10, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29760620/anti-endothelial-cell-antibodies-do-not-correlate-with-disease-activity-in-systemic-sclerosis
#9
Małgorzata Michalska-Jakubus, Małgorzata Kowal, Michał Adamczyk, Dorota Krasowska
Introduction: Anti-endothelial cell antibodies (AECA) recognize endothelial cell proteins and are thought to play an important role in vascular damage observed in systemic scleroderma (SSc) and many other autoimmune diseases. In SSc, AECA were found to be more common in patients with pulmonary hypertension, digital ulcers and nailfold capillaroscopic changes. Until now, there have been no studies examining the association between AECA positivity with the activity and duration of the disease...
April 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29745551/-design-of-training-system-for-foot-ulcer-patients-based-on-three-axis-accelerometer
#10
Rongguo Yan, Yin Qian, Xiaoye Qiu, Junguo Li
The paper introduces a training system for foot ulcer patients based on three axis accelerometer, which uses three axis accelerometer and Apple mobile phone platform to guide foot ulcer patients to carry out a variety of lower limb muscle tissues training. The acceleration values of three directions for the foot training is obtained by analog-to-digital conversion and transmitted to the Apple mobile phone via its Bluetooth low energy. The Apple mobile phone accomplishes acceleration data preprocessing, numerical filtering and adaptive dual-threshold processing by our developed application program, so as to achieve the purpose of foot gesture recognition...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29733400/acute-and-chronic-effects-of-two-different-intravenous-iloprost-regimens-in-systemic-sclerosis-a-pragmatic-non-randomized-trial
#11
Tommaso Schioppo, Annalisa Orenti, Patrizia Boracchi, Orazio De Lucia, Antonella Murgo, Francesca Ingegnoli
Objectives: I.v. iloprost (ILO) may be used in the treatment of refractory RP and digital ulcers. We aim to evaluate the acute and chronic effects of two different ILO regimens by power Doppler US (PDUS) and nailfold videocapillaroscopy. Methods: In this 3-month single-centre pragmatic non-randomized trial, 96 SSc patients were included and stratified according to ILO treatment as: no ILO (group A), ILO once monthly (group B) and ILO for five consecutive days (group C)...
May 3, 2018: Rheumatology
https://www.readbyqxmd.com/read/29718816/a-post-marketing-surveillance-study-of-chronic-wounds-treated-with-a-native-collagen-calcium-alginate-dressing
#12
Matthew Sabo, Lam Le, Raphael A Yaakov, Marissa Carter, Thomas E Serena
Chronic wounds (ie, wounds that fail to progress through a normal, orderly, timely sequence of repair) continue to pose significant clinical and economic burdens. A prospective, descriptive, 3-week post-marketing surveillance study was conducted across 3 wound care centers in the United States to evaluate the effectiveness of a collagen calcium alginate dressing on chronic wounds in conjunction with standard care (SC) practices (eg, offloading, debridement, compression) to support healing. Eligible participants had to be >18 years of age, have at least 1 chronic wound, and no known sensitivity to collagen...
April 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29718811/a-total-offloading-foot-brace-for-treatment-of-diabetic-foot-ulcers-results-from-a-halted-randomized-controlled-trial
#13
David J Johnson, Barbara J Saar, Andrew J Shevitz, Ann H Kim, Lori Hammer, Daniel E Kendrick, Pamela Moorehead, Vikram S Kashyap
INTRODUCTION: Foot offloading is the mainstay treatment for plantar diabetic foot ulcers (DFUs). OBJECTIVE: This multicenter, single-blinded, randomized controlled trial evaluates the efficacy of a total offloading foot brace for healing plantar DFUs. MATERIALS AND METHODS: Seventeen patients were randomized to standard therapy (ie, reducing stress and pressure via mechanical offloading) or offloading foot brace. Comparison of plantar pressures was performed using digital pressure sensing films...
April 18, 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29706243/practical-suggestions-on-intravenous-iloprost-in-raynaud-s-phenomenon-and-digital-ulcer-secondary-to-systemic-sclerosis-systematic-literature-review-and-expert-consensus
#14
REVIEW
Francesca Ingegnoli, Tommaso Schioppo, Yannick Allanore, Roberto Caporali, Michele Colaci, Oliver Distler, Daniel E Furst, Nicolas Hunzelmann, Florenzo Iannone, Dinesh Khanna, Marco Matucci-Cerinic
BACKGROUND: Systemic sclerosis (SSc) is an autoimmune chronic disease characterized by vascular impairment, immune dysfunction and collagen deposition. Raynaud's phenomenon (RP) and digital ulcers (DU) are prominent features of SSc. Intravenous (IV) iloprost (ILO), according to the recently updated EULAR recommendations, is indicated for RP after failure of oral therapy. Moreover, IV ILO could be useful in DU healing. IV ILO is currently available mainly on the European market approved for RP secondary to SSc with 3-5 days infusion cycle...
April 4, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29692255/juvenile-scleroderma-what-has-changed-in-the-meantime
#15
Amra Adrovic, Sezgin Sahin, Kenan Barut, Ozgur Kasapcopur
BACKGROUND: Juvenile scleroderma is a rarely seen chronic connective tissue disorder characterized by stiffening of the skin. The frequency of the disease was reported as one per million. According to organ involvement, the disease is divided into two main forms: systemic and localized scleroderma. OBJECTIVES: Since it is uncommon in children, many aspects of the disease remain discussable. With this review, we aimed to revise recent findings and new developments in this rare condition...
April 22, 2018: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/29691079/the-scleroderma-hand-manifestations-of-disease-and-approach-to-management
#16
REVIEW
Ariel A Williams, Hannah M Carl, Scott D Lifchez
Scleroderma is a rare autoimmune connective tissue disorder that often affects the hands. Manifestations in the hands include calcium deposits within the soft tissues that cause pain and may ulcerate through the skin, digital ischemia resulting in chronic wounds and digital gangrene, and joint contracture. Because of the underlying disease, patients with scleroderma have poorly vascularized tissue and a deficient soft tissue envelope, which make surgery particularly challenging. However, when undertaken with care, surgical intervention is often the best option for addressing the disabling hand conditions that so often accompany this disease...
April 21, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29678418/a-new-method-to-quantify-liner-deformation-within-a-prosthetic-socket-for-below-knee-amputees
#17
Amy L Lenz, Katie A Johnson, Tamara Reid Bush
Many amputees who wear a leg prosthesis develop significant skin wounds on their residual limb. The exact cause of these wounds is unclear as little work has studied the interface between the prosthetic device and user. Our research objective was to develop a quantitative method for assessing displacement patterns of the gel liner during walking for patients with transtibial amputation. Using a reflective marker system and a custom clear socket, evaluations were conducted with a clear transparent test socket mounted over a plaster limb model and a deformable limb model...
April 13, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29652651/prediction-of-organ-involvement-in-systemic-sclerosis-by-serum-biomarkers-and-peripheral-endothelial-function
#18
Shin-Ya Kawashiri, Ayako Nishino, Takashi Igawa, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Akitomo Okada, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Munetoshi Nakashima, Akinari Mizokami, Naoki Matsuoka, Kiyoshi Migita, Fumihide Ogawa, Satoshi Ikeda, Koji Maemura, Hideki Nakamura, Tomoki Origuchi, Takahiro Maeda, Atsushi Kawakami
OBJECTIVES: To identify prognostic factors among serum biomarkers and endothelial vasodilator function findings in patients with systemic sclerosis (SSc). METHODS: This is a clinical observational study. We assessed 60 consecutive SSc patients (44 limited cutaneous-type, 16 diffuse cutaneous-type). Circulating growth differentiation factor-15 (GDF-15), placenta growth factor (PlGF), endostatin, vascular endothelial growth factor (VEGF), and pentraxin 3 (PTX3) were measured by ELISA...
April 12, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29649067/outpatient-negative-pressure-wound-therapy-following-surgical-debridement-results-and-complications
#19
Eran Tamir, Aharon S Finestone, Itay Wiser, Yoram Anekstein, Gabriel Agar
OBJECTIVE: To present results and complications in a case series of outpatients with diabetic and neuropathic foot ulcers with exposed bone following surgical debridement treated with negative-pressure wound therapy (NPWT). METHODS: Retrospective data were obtained from digital medical records from the Maccabi Health Services High Risk Foot Clinic in Tel Aviv, Israel, between 2009 and 2014. Medical records examined were those of clinic outpatients with exposed bone following partial foot amputation or selective bone debridement (University of Texas grade III-A) treated with NPWT...
April 11, 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29648670/lower-limb-ulcers-in-systemic-sclerosis-a-multicentre-retrospective-case-control-study
#20
Gérôme Bohelay, Sophie Blaise, Pierre Levy, Antoine Claeys, Nathalie Baudot, Jean-Francois Cuny, Hervé Maillard, Florence Granel-Brocard, Thierry Boyé, Catherine Lok, Nathalie Bénéton, Camille Francès, Patricia Senet
Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischemic causes (arterial disease and/or microvascular impairment). A retrospective, multicentre, case-control study was conducted in 2013 and 2014, including 45 systemic sclerosis patients presenting lower-limb ulcers between 2008 and 2013. The estimated prevalence of lower-limb ulcers among systemic sclerosis patients was 12...
April 12, 2018: Acta Dermato-venereologica
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