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https://www.readbyqxmd.com/read/29324934/stem-cells-therapy-the-future-in-the-management-of-systemic-sclerosis-a-case-report
#1
Jung In Song, Silvanie Volz, Maria Eirini Liodaki, Peter Mailänder, Konstantinos Kalousis
OBJECTIVE: Systemic sclerosis (SSc) is a connective tissue disorder of unknown etiology, with heterogeneous clinical manifestations and chronic and often progressive course. The diffuse cutaneous form of SSc (dcSSc) is characterized by thickening of the skin (scleroderma) and distinctive involvement of multiple internal organs. Patients with limited cutaneous SSc (lcSSc) generally have long-standing Raynaud's phenomenon before other manifestations of SSc appear. Over the last decade the Interest of adipose-derived cell therapy in regenerative medicine has increased continuously...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29317991/successful-recanalization-of-long-femoro-crural-occlusive-disease-after-failed-bypass-surgery
#2
Grigorios Korosoglou, Tom Eisele, Dorothea Raupp, Christoph Eisenbach, Sorin Giusca
Patients with critical limb ischemia necessitate immediate intervention to restore blood flow to the affected limb. Endovascular procedures are currently preferred for these patients. We describe the case of an 80-year-old female patient who presented to our department with ischemic rest pain and ulceration of the left limb. The patient had history of left femoral popliteal bypass surgery, femoral thromboendarterectomy and patch angioplasty of the same limb 2 years ago. Doppler sonography and magnetic resonance angiography revealed an occlusion of the left superficial femoral artery (SFA) and popliteal artery and of all three infra-popliteal arteries...
December 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/29313109/clinical-features-of-chronic-enteropathy-associated-with-slco2a1-gene-a-new-entity-clinically-distinct-from-crohn-s-disease
#3
Junji Umeno, Motohiro Esaki, Atsushi Hirano, Yuta Fuyuno, Naoki Ohmiya, Shigeyoshi Yasukawa, Fumihito Hirai, Shuji Kochi, Koichi Kurahara, Shunichi Yanai, Keiichi Uchida, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Manabu Nagayama, Hironori Yamamoto, Daiki Abukawa, Fumihiko Kakuta, Kei Onodera, Toshiyuki Matsui, Toshifumi Hibi, Tsuneyoshi Yao, Takanari Kitazono, Takayuki Matsumoto
BACKGROUND: Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a hereditary disease caused by mutations in the SLCO2A1 gene and characterized by multiple small intestinal ulcers of nonspecific histology. SLCO2A1 is also a causal gene of primary hypertrophic osteoarthropathy (PHO). However, little is known about the clinical features of CEAS or PHO. METHODS: Sixty-five Japanese patients recruited by a nationwide survey of CEAS during 2012-2016 were enrolled in this present study...
January 8, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29301476/the-cutaneous-manifestations-are-significantly-related-to-cerebrovascular-in-a-serbian-cohort-of-patients-with-hughes-syndrome
#4
L Stojanovich, A Djokovic, N Stanisavljevic, M Zdravkovic
Objectives To investigate a possible relationship between cerebrovascular, such as stroke and transient ischaemic attack, and various cutaneous manifestations (livedo reticularis, skin ulcerations, pseudovasculitis lesions, superficial cutaneous necrosis and digital gangrene) in antiphospholipid syndrome (APS). This report is based on a Serbian cohort of APS patients. Methods A total of 508 antiphospholipid syndrome APS patients were assessed: 360 with primary (PAPS) and 148 with APS associated with SLE (SAPS)...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29290301/a-systematic-review-of-tests-for-the-detection-and-diagnosis-of-foot-lesions-causing-lameness-in-dairy-cows
#5
Kate J Dutton-Regester, Tamsin S Barnes, John D Wright, John I Alawneh, Ahmad R Rabiee
Foot lesions causing lameness in dairy cows are important economic and welfare issues. Prompt and correct detection and diagnosis are critical for improving economic and welfare outcomes. Few tests are currently available to aid the dairy farmer in the detection and diagnosis of foot lesions. The objectives of this systematic review were to identify those tests that have been investigated for the detection and diagnosis of foot lesions causing lameness in dairy cows, evaluate the methodological quality of the studies investigating the identified tests, compare the accuracy of the identified test, and determine which tests can be recommended for implementation on the farm based on accuracy and practicality for use by dairy farmers...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29279186/digital-dermatitis-in-dairy-cattle-the-contribution-of-different-disease-classes-to-transmission
#6
Floor Biemans, Piter Bijma, Natasja M Boots, Mart C M de Jong
Digital Dermatitis (DD) is a claw disease mainly affecting the hind feet of dairy cattle. Digital Dermatitis is an infectious disease, transmitted via the environment, where the infectious "agent" is a combination of bacteria. The standardized classification for DD lesions developed by Döpfer et al. (1997) and extended by Berry et al. (2012) has six distinct classes: healthy (M0), an active granulomatous area of 0-2 cm (M1), an ulcerative lesion of >2 cm (M2), an ulcerative lesion covered by a scab (M3), alteration of the skin (M4), and a combination of M4 and M1 (M4...
December 22, 2017: Epidemics
https://www.readbyqxmd.com/read/29276221/effects-of-postprandial-body-position-on-gastrointestinal-motility-the-autonomic-nervous-system-and-subjective-comfort
#7
Ayaka Okano, Shun Masuhara, Sonoka Ota, Chie Motegi, Noriko Takabayashi, Tetsuya Ogino
We examined postprandial body positions' effects on gastrointestinal motility, the autonomic nervous system and subjective comfort, i.e., whether lowering the head after a meal is beneficial for gastrointestinal motility and the prevention of pressure ulcer. We examined 10 healthy subjects and compared 3 body positions: (1) Seated upright. (2) Lying on a bed with the head at 60° and knees up by 20° (60° position). (3) Identical to (2) until post-meal; the head was then lowered to 30° (60°-30° position)...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29273187/distal-syme-hallux-amputation-for-tip-of-toe-wounds-and-gangrene-complicated-by-osteomyelitis-of-the-distal-phalanx-surgical-technique-and-outcome-in-consecutive-cases
#8
Troy J Boffeli, Mark S Goss
Distal hallux gangrene and neuropathic ulceration associated with digit deformity frequently result in osteomyelitis of the distal phalanx. Ideal treatment would involve limited resection to preserve function. We describe our surgical technique and retrospective results for distal Syme hallux amputation with plantar flap closure. An institutional review board-approved review was conducted on cases performed over 8 years. A total of 15 consecutive patients (16 digits) with hallux soft tissue loss who had undergone distal Syme hallux amputation were included...
December 19, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29251541/imagej-a-free-easy-and-reliable-method-to-measure-leg-ulcers-using-digital-pictures
#9
Javier Aragón-Sánchez, Yurena Quintana-Marrero, Cristina Aragón-Hernández, María José Hernández-Herero
Wound measurement to document the healing course of chronic leg ulcers has an important role in the management of these patients. Digital cameras in smartphones are readily available and easy to use, and taking pictures of wounds is becoming a routine in specialized departments. Analyzing digital pictures with appropriate software provides clinicians a quick, clean, and easy-to-use tool for measuring wound area. A set of 25 digital pictures of plain foot and leg ulcers was the basis of this study. Photographs were taken placing a ruler next to the wound in parallel with the healthy skin with the iPhone 6S (Apple Inc, Cupertino, CA), which has a camera of 12 megapixels using the flash...
December 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/29251023/autologous-haematopoietic-stem-cell-transplantation-for-japanese-patients-with-systemic-sclerosis-long-term-follow-up-on-a-phase-ii-trial-and-treatment-related-fatal-cardiomyopathy
#10
Hiroyuki Nakamura, Toshio Odani, Shinsuke Yasuda, Atsushi Noguchi, Yuichiro Fujieda, Masaru Kato, Kenji Oku, Toshiyuki Bohgaki, Junichi Sugita, Tomoyuki Endo, Takanori Teshima, Tatsuya Atsumi
OBJECTIVES: The objective of this study is to elucidate the efficacy and safety of autologous haematopoietic stem cell transplantation (HSCT) for Japanese patients with systemic sclerosis (SSc). METHODS: A phase II clinical trial included SSc patients diagnosed within the last three years having at least one of the following clinical features: diffuse skin sclerosis with modified Rodman total thickness skin score (mRSS) ≥ 15, refractory digital ulcer or interstitial lung disease (ILD)...
January 8, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29230521/correction-to-efficacy-and-safety-of-stress-ulcer-prophylaxis-in-critically-ill-patients-a-network-meta-analysis-of-randomized-trials
#11
Waleed Alhazzani, Fayez Alshamsi, Emilie Belley-Cote, Diane Heels-Ansdell, Romina Brignardello-Petersen, Mustafa Alquraini, Anders Perner, Morten Hylander Møller, Mette Krag, Saleh Almenawer, Bram Rochwerg, Joanna Dionne, Roman Jaeschke, Mohammed Alshahrani, Adam Deane, Dan Perri, Lehana Thebane, Awad Al-Omari, Simon Finfer, Deborah Cook, Gordon Guyatt
Owing to an oversight by the authors, all the figures in the last column of Table 2 (upper section: Number needed to treat; lower section: Number needed to harm) in this article were given without the final digit 0 and are thus 10 times too small.
December 11, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29229192/-late-onset-systemic-sclerosis-a-retrospective-study-of-27-patients-diagnosed-after-the-age-of-70
#12
A Achille, L Journeau, O Espitia, J Connault, A Espitia-Thibault, C Durant, F Perrin, M-A Pistorius, A Néel, M Hamidou, C Agard
BACKGROUND: The aim of this study was to describe special features of patients with systemic sclerosis (SSc) diagnosed after the age of 70. PATIENTS AND METHODS: This is a retrospective study of patients aged above 70 years at the time of diagnosis of SSc and followed at an internal medicine unit between 2000 and 2015. Co-morbidities and clinical characteristics were analyzed, as well as survival at 1, 2 and 3 years. RESULTS: Of 246 patients, 27 (11%) were included (89% women, 96% Caucasians, age 78...
December 8, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29218742/prevalence-of-foot-disorders-in-captive-sardinian-partridges-alectoris-barbara-barbara-bonnaterre-1790-as-useful-indicators-of-fitness-to-natural-environment
#13
M G Cappai, A Abd El-Wahab, G Arru, M Muzzeddu, W Pinna
Foot health represents an issue in wild avifauna breeding practices. In particular, prevalence of digital ulceration (DU) and foot pad dermatitis (FPD) are valid indicators of welfare in wildlife conservation centres and may be interpreted as to fitness for bird's reintroduction into the wild. This study meant to test the effects of raising practices on foot pad health in captive Sardinian partridges (Alectoris barbara barbara Bonnaterre, 1790) reared for biodiversity conservation, to assess welfare and fitness to reintroduction into nature...
December 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29207002/disability-fatigue-pain-and-their-associates-in-early-diffuse-cutaneous-systemic-sclerosis-the-european-scleroderma-observational-study
#14
Sébastien Peytrignet, Christopher P Denton, Mark Lunt, Roger Hesselstrand, Luc Mouthon, Alan Silman, Xiaoyan Pan, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon Vonk, Codrina Ancuta, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir-Gurman, Øyvind Midtvedt, Alison C Jordan, Wendy Stevens, Pia Moinzadeh, Frances C Hall, Christian Agard, Marina E Anderson, Elisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Lorinda Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alexander J MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patricia E Carreira, Anne Laure Fauchais, Eric Hachulla, Jennifer Hamilton, Murat Inanç, John S McLaren, Jacob M van Laar, Sanjay Pathare, Susanna Proudman, Anna Rudin, Joanne Sahhar, Brigitte Coppere, Christine Serratrice, Tom Sheeran, Douglas J Veale, Claire Grange, Georges-Selim Trad, Ariane L Herrick
Objectives: Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features. Methods: Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement...
November 30, 2017: Rheumatology
https://www.readbyqxmd.com/read/29201156/evidence-based-management-of-raynaud-s-phenomenon
#15
REVIEW
Ariane L Herrick
Raynaud's phenomenon (RP) is relevant to the rheumatologist because it may signify an underlying connective tissue disease and also because it can be very challenging to treat, especially when it has progressed to digital ulceration or critical ischaemia. This review article discusses diagnosis (does this patient have an underlying connective tissue disease?), including the role for nailfold capillaroscopy, and treatment. Management of 'uncomplicated' RP is first described and then treatment of RP complicated by progression to digital ulceration or critical ischaemia, highlighting recent advances (including phosphodiesterase type 5 inhibition, and endothelin 1 receptor antagonism) and the evidence base underpinning these...
December 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/29198478/the-evaluation-of-a-home-based-program-for-hands-in-patients-with-systemic-sclerosis
#16
Sibila Floriano Landim, Manoel Barros Bertolo, Marcos Felipe Marcatto de Abreu, Ana Paula Del Rio, Cecilia Carmen Mazon, João Francisco Marques-Neto, Janet L Poole, Eduardo de Paiva Magalhães
STUDY DESIGN: This study used a quasi-experimental design where patients were evaluated before and after participation in the self-management program. INTRODUCTION: Hands are commonly affected in systemic sclerosis (SSc). Strategies to maintain or improve hand function are indicated upon diagnosis and throughout the course of the disease. PURPOSE OF THE STUDY: The purpose of this study was to develop and evaluate a home-based program for hands in patients with SSc...
November 29, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29196241/scleroderma-skin-ulcers-definition-classification-and-treatment-strategies-our-experience-and-review-of-the-literature
#17
REVIEW
Dilia Giuggioli, Andreina Manfredi, Lumetti Federica, Colaci Michele, Clodoveo Ferri
BACKGROUND: Skin ulcers (SU) are one of the most frequent manifestations of systemic sclerosis (SSc). SSc-SU are very painful, often persistent and recurrent; they may lead to marked impairment of patient's activities and quality of life. Despite their severe impact on the whole SSc patient's management, the proposed definition, classification criteria, and therapeutic strategies of SSc-SU are still controversial. OBJECTIVE: The present study aimed to elaborate a comprehensive proposal of definition, classification, and therapeutic strategy of SSc-SU on the basis of our long-term single center experience along with a careful revision of the world literature on the same topic...
November 28, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29164658/successful-treatment-of-raynaud-s-phenomenon-and-digital-ulcers-in-systemic-sclerosis-patients-with-botulinum-toxin-b-injection-assessment-of-peripheral-vascular-disorder-by-angiography-and-dermoscopic-image-of-nail-fold-capillary
#18
Sei-Ichiro Motegi, Akiko Sekiguchi, Shintaro Saito, Hirohisa Ishibuchi, Chikako Kishi, Masahito Yasuda, Osamu Ishikawa
We recently identified the efficacy and safety of a botulinum toxin (BTX)-A/B in Raynaud's phenomenon (RP) and digital ulcers (DU) in Japanese patients with systemic sclerosis (SSc). Detailed assessments of peripheral vascular disorder using angiography and dermoscopic images of nail fold capillaries have not been performed previously. This study aimed to evaluate the effect of BTX-B on SSc-associated peripheral vascular disorder. Two SSc patients who suffered with RP and DU were treated with a BTX-B injection, and thereafter the symptoms of RP were improved and DU healed in both patients...
November 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29155985/a-systematic-review-the-management-and-outcomes-of-ileal-pouch-strictures
#19
Jonathan P Segal, Guy Worley, Samuel O Adegbola, Kapil Sahnan, Philip Tozer, Phillip F C Lung, Omar D Faiz, Susan K Clark, Ailsa L Hart
Background: Restorative proctocolectomy with ileal pouch-anal anastomosis removes the diseased tissue in ulcerative colitis but also allows gastrointestinal continuity and stoma-free living. Pouch strictures are a complication with a reported incidence of 5-38%. The three areas where pouch strictures occur are in the pouch inlet, mid-pouch and pouch-anal anastomosis. Aim: To undertake a systematic review of the literature and to identify management strategies available for pouch-anal, mid-pouch and pre-pouch ileal strictures and their outcomes...
November 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29151514/a-case-of-dermatomyositis-complicated-by-digital-ischemia-and-lung-adenocarcinoma-in-a-patient-with-positive-anti-signal-recognition-particle-antibodies
#20
Takashi Nawata, Makoto Kubo, Hitomi Mitsui, Keiji Oishi, Masatoshi Omoto, Takashi Kanda, Masafumi Yano
A 58-year-old Japanese woman was diagnosed with anti-signal recognition particle (SRP)-positive dermatomyositis associated with Sjögren's syndrome, rheumatoid arthritis and lung adenocarcinoma. She presented with cutaneous lesions, including ulceration of her right middle finger. Tissue specimens obtained from her right deltoid muscle were positive for CD4(+) T-cell infiltration and the sarcolemma showed the upregulation of major histocompatibility complex (MHC) class I antigens. The present case suggests that overlapping autoimmune diseases or complications of malignancy may result in an atypical clinical presentations and histological findings in patients with anti-SRP antibody-positive dermatomyositis...
November 20, 2017: Internal Medicine
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