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https://www.readbyqxmd.com/read/28629476/stromal-vascular-fraction-cells-for-the-treatment-of-critical-limb-ischemia-a-pilot-study
#1
Adas Darinskas, Mindaugas Paskevicius, Gintaras Apanavicius, Gintaris Vilkevicius, Liutauras Labanauskas, Thomas E Ichim, Rytis Rimdeika
BACKGROUND: Cell-based therapy is being explored as an alternative treatment option for critical limb ischemia (CLI), a disease associated with high amputation and mortality rates and poor quality of life. However, therapeutic potential of uncultured adipose-derived stromal vascular fraction (SVF) cells has not been evaluated as a possible treatment. In this pilot study, we investigated the efficacy of multiple injections of autologous uncultured adipose-derived SVF cells to treat patients with CLI...
June 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28619741/saddle-nose-and-bilateral-cauliflower-ear-deformities-with-pyoderma-gangrenosum-like-ulcers-cavitary-pulmonary-lesions-digital-gangrene-and-pulselessness-in-a-young-female
#2
Sweta Subhadarshani, Vishal Gupta, Anurag Chahal, Kaushal K Verma
We report a young female who presented with saddle-nose and bilateral cauliflower ear deformities along with pyoderma gangrenosum-like ulcers, digital gangrene and pulselessness. Subsequently, she was found to have bilateral conductive hearing loss, a corneal opacity, mild aortic regurgitation and radiological evidence of cavitary changes in lungs and aortoarteritis. Our patient had a constellation of symptoms which posed a diagnostic challenge. Finally, a diagnosis of relapsing polychondritis with several unusual features was made...
June 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28612500/using-image-j-to-document-healing-in-ulcers-of-the-foot-in-diabetes
#3
William J Jeffcoate, Alison J Musgrove, Nadina B Lincoln
The aim of the study was to assess the reliability of measuring the cross-sectional area of diabetic foot ulcers using Image J software. The inter- and intra-rater reliability of ulcer area measures were assessed using digital images of acetate tracings of ulcers of the foot affecting 31 participants in an off-loading randomised trial. Observations were made independently by five specialist podiatrists, one of whom was experienced in the use of Image J software and educated the other four in a single session...
June 13, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28602918/angiogenic-and-angiostatic-factors-in-renal-scleroderma-associated-vasculopathy
#4
Antonietta Gigante, Navarini Luca, Margiotta Domenico, Amoroso Antonio, Barbano Biagio, Cianci Rosario, Afeltra Antonella, Rosato Edoardo
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis. Intrarenal resistance index are considered markers of renal vasculopathy. The aim of the study is to evaluate angiogenic and angiostatic factors (VEGF and endostatin) in SSc patients and to correlate with intrarenal hemodynamic parameters...
June 8, 2017: Microvascular Research
https://www.readbyqxmd.com/read/28598975/vitamin-d-deficiency-and-clinical-correlations-in-systemic-sclerosis-patients-a-retrospective-analysis-for-possible-future-developments
#5
Amelia Chiara Trombetta, Vanessa Smith, Emanuele Gotelli, Massimo Ghio, Sabrina Paolino, Carmen Pizzorni, Amber Vanhaecke, Barbara Ruaro, Alberto Sulli, Maurizio Cutolo
OBJECTIVE: Assessment of serum 25-hydroxyvitamin D (25(OH)D) correlations with clinical parameters and evaluation of the efficacy of standard oral supplementation in systemic sclerosis (SSc) patients. METHODS: 154 SSc patients were recruited, in all seasons. Serum 25(OH)D concentrations were evaluated using LIAISON 25-OH (Diasorin, Italy). Medsger disease severity scale (DSS), nailfold videocapillaroscopy (NVC) and all instrumental exam contemplated by international guidelines were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28598784/a-pilot-study-using-high-frequency-ultrasound-to-measure-digital-ulcers-a-possible-outcome-measure-in-systemic-sclerosis-clinical-trials
#6
Michael Hughes, Tonia Moore, Joanne Manning, Graham Dinsdale, Ariane L Herrick, Andrea Murray
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June 7, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28580415/kid-project-an-internet-based-digital-video-atlas-of-capsule-endoscopy-for-research-purposes
#7
Anastasios Koulaouzidis, Dimitris K Iakovidis, Diana E Yung, Emanuele Rondonotti, Uri Kopylov, John N Plevris, Ervin Toth, Abraham Eliakim, Gabrielle Wurm Johansson, Wojciech Marlicz, Georgios Mavrogenis, Artur Nemeth, Henrik Thorlacius, Gian Eugenio Tontini
BACKGROUND AND AIMS:  Capsule endoscopy (CE) has revolutionized small-bowel (SB) investigation. Computational methods can enhance diagnostic yield (DY); however, incorporating machine learning algorithms (MLAs) into CE reading is difficult as large amounts of image annotations are required for training. Current databases lack graphic annotations of pathologies and cannot be used. A novel database, KID, aims to provide a reference for research and development of medical decision support systems (MDSS) for CE...
June 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28579046/pathogenesis-and-treatment-of-toe-lesions-in-cattle-including-nonhealing-toe%C3%A2-lesions
#8
REVIEW
Johann Kofler
Toe lesions in cattle include apical white line disease, thin soles, toe ulcers, toe necrosis, digital dermatitis-associated toe ulcers/toe necrosis, and fracture of the claw capsule and the apex of the distal phalanx. For anatomic reasons, the early stages of toe abnormalities (thin sole, apical white line disease, toe ulcer) are at risk of developing into a bone infection. The prevalence of toe lesions differs in dairy herds and feedlots: it is low at the animal level in feedlots and dairies; however, the herd prevalence of toe lesions can reach 50% in dairy herds with endemic digital dermatitis infection...
July 2017: Veterinary Clinics of North America. Food Animal Practice
https://www.readbyqxmd.com/read/28576600/the-role-of-nailfoldcapillaroscopy-in-the-assessment-of-internal-organ-involvement-in-systemic-sclerosis-a-critical-review
#9
REVIEW
Stergios Soulaidopoulos, Eva Triantafyllidou, Alexandros Garyfallos, George D Kitas, Theodoros Dimitroulas
Endothelial dysfunction and microvascular damage constitute the hallmarks of systemic sclerosis (SSc), explaining much of the pathophysiology and clinical manifestations of the disease. Nailfold videocapillaroscopy (NVC) is an established method for the assessment of the microvasculature, aiding in distinguishing different types of structural vascular abnormalities. Until recently, NVC was used in the diagnosis of SSc as well as in the assessment and follow-up of peripheral digital vasculopathy. On the top of digital ulcers, internal organ involvement such as myocardial dysfunction, pulmonary vascular and/or parenchymal lung disease characterizes severe SSc imparting a high risk of mortality...
May 30, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28576149/survival-and-quality-of-life-in-incident-systemic-sclerosis-related-pulmonary-arterial-hypertension
#10
Kathleen Morrisroe, Wendy Stevens, Molla Huq, David Prior, Jo Sahhar, Gene-Siew Ngian, David Celermajer, Jane Zochling, Susanna Proudman, Mandana Nikpour
BACKGROUND: Pulmonary arterial hypertension (PAH) is a leading cause of mortality in systemic sclerosis (SSc). We sought to determine survival, predictors of mortality, and health-related quality of life (HRQoL) related to PAH in a large SSc cohort with PAH. METHODS: We studied consecutive SSc patients with newly diagnosed (incident) World Health Organization (WHO) Group 1 PAH enrolled in a prospective cohort between 2009 and 2015. Survival methods were used to determine age and sex-adjusted standardised mortality ratio (SMR) and years of life lost (YLL), and to identify predictors of mortality...
June 2, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28575546/quantifying-digital-ulcers-in-systemic-sclerosis-reliability-of-digital-planimetry-in-measuring-lesion-size
#11
V Simpson, M Hughes, J Wilkinson, A L Herrick, G Dinsdale
Objective Digital ulcers (DUs) are a major problem in patients with systemic sclerosis (SSc), causing severe pain, and impairment of hand function. In addition, DUs heal slowly and sometimes become infected, which can lead to gangrene and necessitate amputation, without appropriate intervention. A reliable, objective method for assessing DU healing or progression is needed in both clinical and research arenas. The objectives were: (1) to compare two digital planimetry methods of DU area measurement (ellipse and free hand region-of-interest [ROI]) applied to photographs of DUs, and (2) to assess reliability of photographic calibration and the two area measurement methods...
June 2, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28549916/utility-of-carotid-ultrasonography-in-management-of-an-atypical-high-vascular-risk-patient-with-recurrent-calcified-cerebral-embolic-stroke
#12
John W Liang, Jesse Weinberger, Aaron Tansy
OBJECTIVE: To describe a case of recurrent calcified cerebral emboli (CCE)-related acute ischemic stroke (AIS) and the diagnostic utility of plaque morphology characterization on carotid ultrasound. BACKGROUND: CCE are a rare cause of AIS. CCE-related AIS has been previously reported only in high vascular-risk patients such as those with severe carotid stenosis, widespread atheromatous disease, or cardiac valvular disease. CCE-related AIS from a carotid origin has not been reported in patients without carotid stenosis...
May 23, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28545512/tie2-as-a-novel-key-factor-of-microangiopathy-in-systemic-sclerosis
#13
Falk Moritz, Janine Schniering, Jörg H W Distler, Renate E Gay, Steffen Gay, Oliver Distler, Britta Maurer
BACKGROUND: The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth factor (VEGF), hypoxia, and inflammation, acts as an antagonist. Tie2 signalling is also attenuated by soluble Tie2 (sTie2), the extracellular domain of the receptor, which is shed upon stimulation with VEGF. Herein, we investigate the role of Ang/Tie2 in the peripheral vasculopathy in systemic sclerosis (SSc) including animal models...
May 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28544177/giant-orf-tumor-in-an-immunocompromised-patient
#14
L Polivka, P Moguelet, J F Meritet, N Ouali, C Francès, P Senet
Herein, we report the efficacy and the safety of open-spray cryotherapy in an immunocompromised woman presenting with tumor-like orf lesion. A 58-year-old woman was referred with a 4-month history of an undiagnosed, painful, ulcerated, tumor-like lesion on the last phalanx of the fifth digit of her left hand. Six months earlier, the woman had received a cadaveric kidney transplant for an indication of focal segmental glomerulosclerosis. This article is protected by copyright. All rights reserved.
May 23, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28541450/macrocirculation-versus-microcirculation-and-digital-ulcers-in-systemic-sclerosis-patients-macro-microcirculation-and-scleroderma
#15
Maurizio Cutolo, Barbara Ruaro, Vanessa Smith
No abstract text is available yet for this article.
May 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/28507181/fli1-deficiency-induces-cxcl6-expression-in-dermal-fibroblasts-and-endothelial-cells-contributing-to-the-development-of-fibrosis-and-vasculopathy-in-systemic-sclerosis
#16
Takashi Taniguchi, Yoshihide Asano, Kouki Nakamura, Takashi Yamashita, Ryosuke Saigusa, Yohei Ichimura, Takehiro Takahashi, Tetsuo Toyama, Ayumi Yoshizaki, Shinichi Sato
OBJECTIVE: CXCL6, a chemokine with proangiogenic property, is reported to be involved in vasculopathy associated with systemic sclerosis (SSc). We investigated the contribution of CXCL6 to SSc development by focusing on the association of friend leukemia virus integration 1 (Fli1) deficiency, a potential predisposing factor of SSc, with CXCL6 expression and clinical correlation of serum CXCL6 levels. METHODS: mRNA levels of target genes and the binding of Fli1 to the CXCL6 promoter were evaluated by quantitative reverse transcription-PCR and chromatin immunoprecipitation, respectively...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28499034/functional-disability-and-its-predictors-in-systemic-sclerosis-a-study-from-the-desscipher-project-within-the-eustar-group
#17
Veronika K Jaeger, Oliver Distler, Britta Maurer, Laszlo Czirják, Veronika Lóránd, Gabriele Valentini, Serena Vettori, Francesco Del Galdo, Giuseppina Abignano, Christopher Denton, Svetlana Nihtyanova, Yannick Allanore, Jerome Avouac, Gabriele Riemekasten, Elise Siegert, Dörte Huscher, Marco Matucci-Cerinic, Serena Guiducci, Marc Frerix, Ingo H Tarner, Beata Garay Toth, Beat Fankhauser, Jörg Umbricht, Anastasia Zakharova, Carina Mihai, Franco Cozzi, Sule Yavuz, Nicolas Hunzelmann, Simona Rednic, Alessandra Vacca, Tim Schmeiser, Valeria Riccieri, Paloma García de la Peña Lefebvre, Armando Gabrielli, Brigitte Krummel-Lorenz, Duska Martinovic, Codrina Ancuta, Vanessa Smith, Ulf Müller-Ladner, Ulrich A Walker
Objectives.: The multisystem manifestations of SSc can greatly impact patients' quality of life. The aim of this study was to identify factors associated with disability in SSc. Methods.: SSc patients from the prospective DeSScipher cohort who had completed the scleroderma health assessment questionnaire (SHAQ), a disability score that combines the health assessment questionnaire and five visual analogue scales, were included in this analysis. The effect of factors possibly associated with disability was analysed with multiple linear regressions...
May 11, 2017: Rheumatology
https://www.readbyqxmd.com/read/28488332/dermoscopic-features-of-digital-mucous-cysts-a-study-of-23-cases
#18
Je Byeong Chae, Jungyoon Ohn, Je-Ho Mun
Digital mucous cysts (DMC) are common benign myxoid cysts typically located on the fingers and toes. Recently, dermoscopic patterns of DMC were reported. However, only a small number of cases were described in the published work; therefore, information on this topic is scarce in the published work. We investigated dermoscopic patterns of histopathologically diagnosed DMC. In total, 23 cases were enrolled in this study. Polarized dermoscopy revealed vascular patterns in 13 cases (56.5%), with arborizing vascular patterns, dotted vessels, linear vessels and polymorphous vessels in eight (34...
May 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28482872/disturbed-microcirculation-in-the-hands-of-patients-with-systemic-sclerosis-detected-by-fluorescence-optical-imaging-a-pilot-study
#19
Stefanie Friedrich, Susanne Lüders, Stephanie Gabriele Werner, Anne-Marie Glimm, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Marina Backhaus, Sarah Ohrndorf
BACKGROUND: Utilising fluorescence optical imaging (FOI), the distribution of an intravenously applied colouring agent indocyanine green (ICG) can be analysed with the potential to identify malperfusion by little to no tissue enhancement. Systemic sclerosis (SSc) is characterised by the presence of digital ulcers reflecting progressive vasculopathy. The objective was to investigate the potential of FOI in the detection of disturbed microcirculation in the hands and fingers of patients with SSc and to link FOI findings to clinical signs of ischemia such as digital ulcers and pitting scars...
May 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28479757/premature-ovarian-failure-an-unusual-manifestation-of-systemic-sclerosis
#20
Aruna Nigam, Anupam Prakash, Shikha Sharma, Narendra Kumar
A 31-year-old woman presented with secondary amenorrhoea and inability to conceive, which was of 3 years duration. She had Raynaud's phenomenon for 16 years, primary hypothyroidism for 5 years, digital ulcers for 4 years and skin tightening for 2 years. She had an expressionless face, with loss of wrinkles and restriction of the mouth opening along with flexion contractures of the hands and the terminal digit resorptions. Investigations showed Antinuclear antibodies (ANA) and anti-Scl 70 positivity confirming the presence of systemic sclerosis (SSc)...
January 2017: Journal of Human Reproductive Sciences
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