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https://www.readbyqxmd.com/read/28914051/chromosome-centric-human-proteome-project-allies-with-developmental-biology-a-case-study-of-the-role-of-y-chromosome-genes-in-organ-development
#1
Anna Meyfour, Paria Pooyan, Sara Pahlavan, Mostafa Rezaei-Tavirani, Hamid Gourabi, Hossein Baharvand, Ghasem Hosseini Salekdeh
One of the main goals of Chromosome-Centric Human Proteome Project is to identify protein evidence for missing proteins (MPs). Here, we present a case study of the role of Y chromosome genes in organ development and how to overcome the challenges facing MPs identification by employing human pluripotent stem cell differentiation into cells of different organs yielding unprecedented biological insight into adult silenced proteins. Y chromosome is a male-specific sex chromosome which escapes meiotic recombination...
September 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28912458/y-chromosome-mitochondrial-dna-and-childhood-behavioural-traits
#2
Laurence J Howe, A Mesut Erzurumluoglu, George Davey Smith, Santiago Rodriguez, Evie Stergiakouli
Many psychiatric traits are sexually dimorphic in terms of prevalence, age of onset, progression and prognosis; sex chromosomes could play a role in these differences. In this study we evaluated the association between Y chromosome and mitochondrial DNA haplogroups with sexually-dimorphic behavioural and psychiatric traits. The study sample included 4,211 males and 4,009 females with mitochondrial DNA haplogroups and 4,788 males with Y chromosome haplogroups who are part of the Avon Longitudinal Study of Parents and Children (ALSPAC) based in the United Kingdom...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903432/genetic-variation-and-forensic-characteristic-analysis-of-25-strs-of-a-novel-fluorescence-co-amplification-system-in-chinese-southern-shaanxi-han-population
#3
Yao-Shun Liu, Jian-Gang Chen, Ting Mei, Yu-Xin Guo, Hao-Tian Meng, Jian-Fei Li, Yuan-Yuan Wei, Xiao-Ye Jin, Bo-Feng Zhu, Li-Ping Zhang
We analyzed the genetic polymorphisms of 15 autosomal and 10 Y-chromosomal STR loci in 214 individuals of Han population from Southern Shaanxi of China and studied the genetic relationships between Southern Shaanxi Han and other populations. We observed a total of 150 alleles at 15 autosomal STR loci with the corresponding allelic frequencies ranging from 0.0023 to 0.5210, and the combined power of discrimination and exclusion for the 15 autosomal STR loci were 0.99999999999999998866 and 0.999998491, respectively...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903352/analysis-of-bos-taurus-and-sus-scrofa-x-and-y-chromosome-transcriptome-highlights-reproductive-driver-genes
#4
Faheem Ahmed Khan, Hui Liu, Hao Zhou, Kai Wang, Muhammad Tahir Ul Qamar, Nuruliarizki Shinta Pandupuspitasari, Zhang Shujun
The biology of sperm, its capability of fertilizing an egg and its role in sex ratio are the major biological questions in reproductive biology. To answer these question we integrated X and Y chromosome transcriptome across different species: Bos taurus and Sus scrofa and identified reproductive driver genes based on Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. Our strategy resulted in 11007 and 10445 unique genes consisting of 9 and 11 reproductive modules in Bos taurus and Sus scrofa, respectively...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28900279/next-generation-sequencing-plus-ngs-with-y-chromosomal-markers-for-forensic-pedigree-searches
#5
Xiaoqin Qian, Jiayi Hou, Zheng Wang, Yi Ye, Min Lang, Tianzhen Gao, Jing Liu, Yiping Hou
There is high demand for forensic pedigree searches with Y-chromosome short tandem repeat (Y-STR) profiling in large-scale crime investigations. However, when two Y-STR haplotypes have a few mismatched loci, it is difficult to determine if they are from the same male lineage because of the high mutation rate of Y-STRs. Here we design a new strategy to handle cases in which none of pedigree samples shares identical Y-STR haplotype. We combine next generation sequencing (NGS), capillary electrophoresis and pyrosequencing under the term 'NGS+' for typing Y-STRs and Y-chromosomal single nucleotide polymorphisms (Y-SNPs)...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28894175/sexual-congruency-in-the-connectome-and-translatome-of-vta-dopamine-neurons
#6
Amanda S Chung, Samara M Miller, Yanjun Sun, Xiangmin Xu, Larry S Zweifel
The ventral tegmental area (VTA) dopamine system is important for reward, motivation, emotion, learning, and memory. Dysfunctions in the dopamine system are linked to multiple neurological and neuropsychiatric disorders, many of which present with sex differences. Little is known about the extent of heterogeneity in the basic organization of VTA dopamine neurons with regard to sex. Here, we characterized the cell-specific connectivity of VTA dopamine neurons, their mRNA translational profile, and basic electrophysiological characteristics in a common strain of mice...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28888135/strseq-a-catalog-of-sequence-diversity-at-human-identification-short-tandem-repeat-loci
#7
Katherine Butler Gettings, Lisa A Borsuk, David Ballard, Martin Bodner, Bruce Budowle, Laurence Devesse, Jonathan King, Walther Parson, Christopher Phillips, Peter M Vallone
The STR Sequencing Project (STRSeq) was initiated to facilitate the description of sequence-based alleles at the Short Tandem Repeat (STR) loci targeted in human identification assays. This international collaborative effort, which has been endorsed by the ISFG DNA Commission, provides a framework for communication among laboratories. The initial data used to populate the project are the aggregate alleles observed in targeted sequencing studies across four laboratories: National Institute of Standards and Technology (N=1786), Kings College London (N=1043), University of North Texas Health Sciences Center (N=839), and University of Santiago de Compostela (N=944), for a total of 4612 individuals...
September 1, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28885981/from-surnames-to-linguistic-and-genetic-diversity-five-centuries-of-internal-migrations-in-spain
#8
Roberto Rodríguez-Díaz, María José Blanco-Villegas, Franz Manni
In a previous study concerning 33,753 single Spanish surnames (considered as tokens) occurring 51,419,788 times we have shown that the present-day geography of contemporary surname variability in Spain still corresponds to the political geography of the country at the end of the Middle Ages. Here we reprocess the same database, by clustering surnames with Self-Organizing Maps (SOMs) according to their geographic distribution, to identify the monophyletic surnames showing a geo-historical origin in one of the 47 provinces of continental Spain...
September 1, 2017: Journal of Anthropological Sciences, Rivista di Antropologia: JASS
https://www.readbyqxmd.com/read/28884802/a-female-viking-warrior-confirmed-by-genomics
#9
Charlotte Hedenstierna-Jonson, Anna Kjellström, Torun Zachrisson, Maja Krzewińska, Veronica Sobrado, Neil Price, Torsten Günther, Mattias Jakobsson, Anders Götherström, Jan Storå
OBJECTIVES: The objective of this study has been to confirm the sex and the affinity of an individual buried in a well-furnished warrior grave (Bj 581) in the Viking Age town of Birka, Sweden. Previously, based on the material and historical records, the male sex has been associated with the gender of the warrior and such was the case with Bj 581. An earlier osteological classification of the individual as female was considered controversial in a historical and archaeological context...
September 8, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28884289/dispersals-of-the-siberian-y-chromosome-haplogroup-q-in-eurasia
#10
Yun-Zhi Huang, Horolma Pamjav, Pavel Flegontov, Vlastimil Stenzl, Shao-Qing Wen, Xin-Zhu Tong, Chuan-Chao Wang, Ling-Xiang Wang, Lan-Hai Wei, Jing-Yi Gao, Li Jin, Hui Li
The human Y-chromosome has proven to be a powerful tool for tracing the paternal history of human populations and genealogical ancestors. The human Y-chromosome haplogroup Q is the most frequent haplogroup in the Americas. Previous studies have traced the origin of haplogroup Q to the region around Central Asia and Southern Siberia. Although the diversity of haplogroup Q in the Americas has been studied in detail, investigations on the diffusion of haplogroup Q in Eurasia and Africa are still limited. In this study, we collected 39 samples from China and Russia, investigated 432 samples from previous studies of haplogroup Q, and analyzed the single nucleotide polymorphism (SNP) subclades Q1a1a1-M120, Q1a2a1-L54, Q1a1b-M25, Q1a2-M346, Q1a2a1a2-L804, Q1a2b2-F1161, Q1b1a-M378, and Q1b1a1-L245...
September 7, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28881049/classical-gonadoblastoma-its-relationship-to-the-dissecting-variant-and-undifferentiated-gonadal-tissue
#11
REVIEW
Lawrence M Roth, Liang Cheng
Classical gonadoblastoma occurs almost entirely in the dysgenetic gonads of an individual who has a disorder of sex development. Approximately 40% of such neoplasms are bilateral. Almost all gonadoblastomas occur in patients who have a Y chromosome or part thereof; testis specific protein Y-encoded 1 (TSPY1) is the putative gene. If a gonad in a patient who has a disorder of sex development contains germ cells with delayed maturation and also harbors the TSPY1 gene, the cells can undergo transformation to classical gonadoblastoma...
September 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28876295/y-chromosome-dna-in-women-s-vaginal-samples-as-a-biomarker-of-recent-vaginal-sex-and-condom-use-with-male-partners-in-the-hpv-infection-and-transmission-among-couples-through-heterosexual-activity-cohort-study
#12
Talía Malagón, Ann Burchell, Mariam El-Zein, Julie Guénoun, Pierre-Paul Tellier, François Coutlée, Eduardo L Franco
BACKGROUND: Y chromosome DNA from male epithelial and sperm cells was detected in vaginal samples after unprotected sex in experimental studies. We assessed the strength of this association in an observational setting to examine the utility of Y chromosome DNA as a biomarker of recent sexual behaviors in epidemiological studies. METHODS: The HPV (human papillomavirus) Infection and Transmission Among Couples Through Heterosexual Activity cohort study enrolled 502 women attending a university or college in Montréal, Canada, and their male partners from 2005 to 2010...
August 4, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28874168/holocentric-chromosome-evolution-in-kissing-bugs-hemiptera-reduviidae-triatominae-diversification-of-repeated-sequences
#13
Sebastián Pita, Pedro Lorite, Jesús Vela, Pablo Mora, Teresa Palomeque, Khoa Pham Thi, Francisco Panzera
BACKGROUND: The analysis of the chromosomal and genome evolution in organisms with holocentric chromosomes is restricted by the lack of primary constriction or centromere. An interesting group is the hemipteran subfamily Triatominae, vectors of Chagas disease, which affects around 6 to 7 million people worldwide. This group exhibits extensive variability in the number and chromosomal location of repeated sequences such as heterochromatin and ribosomal genes. This paper tries to reveal the significant differences of the repeated sequences among Triatoma species through the use of genomic DNA probes...
September 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28874128/relationship-of-genetic-causes-and-inhibin-b-in-non-obstructive-azoospermia-spermatogenic-failure
#14
Qing-Jun Chu, Rui Hua, Chen Luo, Qing-Jie Chen, Biao Wu, Song Quan, Yong-Tong Zhu
BACKGROUND: Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels. Till now, few studies have concerned the relationship of genetic causes and inhibin B in NOA. METHODS: In this retrospective study, 322 men with NOA in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. The level of follicle stimulating hormone (FSH), inhibin B, Y chromosome microdeletion test (YCMD) and karyotype were measured...
September 6, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28873375/non-invasive-prenatal-testing-for-sex-chromosome-aneuploidy-in-routine-clinical-practice
#15
Louise Kornman, Ricardo Palma-Dias, Debbie Nisbet, Fergus Scott, Melody Menezes, Fabricio da Silva Costa, Andrew McLennan
OBJECTIVES: To assess the accuracy of non-invasive prenatal testing (NIPT) for sex chromosome aneuploidy (SCA) in routine clinical practice and to review counselling and sonographic issues arising in SCA cases. METHODS: Three specialist Australian obstetric ultrasound and prenatal diagnosis practices offering NIPT after 10 weeks' gestation participated in this study. NIPT was reported for chromosomes 21, 18, 13, X, and Y. RESULTS: NIPT screening was performed in 5,267 singleton pregnancies...
September 6, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28872195/goat-domestication-and-breeding-a-jigsaw-of-historical-biological-and-molecular-data-with-missing-pieces
#16
REVIEW
M Amills, J Capote, G Tosser-Klopp
Domestic goats (Capra hircus) are spread across the five continents with a census of 1 billion individuals. The worldwide population of goats descends from a limited number of bezoars (Capra aegagrus) domesticated 10 000 YBP (years before the present) in the Fertile Crescent. The extraordinary adaptability and hardiness of goats favoured their rapid spread over the Old World, reaching the Iberian Peninsula and Southern Africa 7000 YBP and 2000 YBP respectively. Molecular studies have revealed one major mitochondrial haplogroup A and five less frequent haplogroups B, C, D, F and G...
September 4, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28860320/cross-species-y-chromosome-function-between-malaria-vectors-of-the-anopheles-gambiae%C3%A2-species-complex
#17
Federica Bernardini, Roberto Galizi, Mariana Wunderlich, Chrysanthi Taxiarchi, Nace Kranjc, Kyros Kyrou, Andrew Hammond, Tony Nolan, Mara N K Lawniczak, Philippos Aris Papathanos, Andrea Crisanti, Nikolai Windbichler
Y chromosome function, structure and evolution is poorly understood in many species including the Anopheles genus of mosquitoes, an emerging model system for studying speciation that also represents the major vectors of malaria. While the Anopheline Y had previously been implicated in male mating behavior, recent data from the Anopheles gambiae complex suggests that, apart from the putative primary sex-determiner, no other genes are conserved on the Y. Studying the functional basis of the evolutionary divergence of the Y chromosome in the gambiae complex is complicated by complete F1 male hybrid sterility...
August 31, 2017: Genetics
https://www.readbyqxmd.com/read/28855362/a-father-effect-explains-sex-ratio-bias
#18
Aurelio F Malo, Felipe Martinez-Pastor, Francisco Garcia-Gonzalez, Julián Garde, Jonathan D Ballou, Robert C Lacy
Sex ratio allocation has important fitness consequences, and theory predicts that parents should adjust offspring sex ratio in cases where the fitness returns of producing male and female offspring vary. The ability of fathers to bias offspring sex ratios has traditionally been dismissed given the expectation of an equal proportion of X- and Y-chromosome-bearing sperm (CBS) in ejaculates due to segregation of sex chromosomes at meiosis. This expectation has been recently refuted. Here we used Peromyscus leucopus to demonstrate that sex ratio is explained by an exclusive effect of the father, and suggest a likely mechanism by which male-driven sex-ratio bias is attained...
August 30, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28854642/papio-baboon-species-indicative-alu-elements
#19
Jerilyn A Walker, Vallmer E Jordan, Cody J Steely, Thomas O Beckstrom, Cullen L McDaniel, Corey P St Romain, Emily C Bennett, Arianna Robichaux, Brooke N Clement, Miriam K Konkel, Mark A Batzer
The genus of Papio (baboon) has six recognized species separated into Northern and Southern clades, each comprised of three species distributed across the African continent. Geographic origin and phenotypic variants such as coat color and body size have commonly been used to identify different species. The existence of multiple hybrid zones, both ancient and current, have complicated efforts to characterize the phylogeny of Papio baboons. More recently, mitochondrial DNA (mtDNA) and Y-chromosome genetic markers have been utilized for species identification with particular focus on the hybrid zones...
June 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28853720/the-y-chromosome-a-blueprint-for-men-s-health
#20
REVIEW
Akhlaq A Maan, James Eales, Artur Akbarov, Joshua Rowland, Xiaoguang Xu, Mark A Jobling, Fadi J Charchar, Maciej Tomaszewski
The Y chromosome has long been considered a 'genetic wasteland' on a trajectory to completely disappear from the human genome. The perception of its physiological function was restricted to sex determination and spermatogenesis. These views have been challenged in recent times with the identification of multiple ubiquitously expressed Y-chromosome genes and the discovery of several unexpected associations between the Y chromosome, immune system and complex polygenic traits. The collected evidence suggests that the Y chromosome influences immune and inflammatory responses in men, translating into genetically programmed susceptibility to diseases with a strong immune component...
August 30, 2017: European Journal of Human Genetics: EJHG
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