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https://www.readbyqxmd.com/read/28329355/international-recommendations-for-electrocardiographic-interpretation-in-athletes
#1
Sanjay Sharma, Jonathan A Drezner, Aaron Baggish, Michael Papadakis, Mathew G Wilson, Jordan M Prutkin, Andre La Gerche, Michael J Ackerman, Mats Borjesson, Jack C Salerno, Irfan M Asif, David S Owens, Eugene H Chung, Michael S Emery, Victor F Froelicher, Hein Heidbuchel, Carmen Adamuz, Chad A Asplund, Gordon Cohen, Kimberly G Harmon, Joseph C Marek, Silvana Molossi, Josef Niebauer, Hank F Pelto, Marco V Perez, Nathan R Riding, Tess Saarel, Christian M Schmied, David M Shipon, Ricardo Stein, Victoria L Vetter, Antonio Pelliccia, Domenico Corrado
Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural, or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete...
February 20, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28327497/the-mapping-competences-of-the-nurse-case-care-manager-in-the-context-of-intensive-care
#2
Emanuela Alfieri, Anna Chiara Ferrini, Francesca Gianfrancesco, Gianluca Lise, Giovanni Messana, Lorenzo Tirelli, Ana Lorenzo, Leopoldo Sarli
BACKGROUND AND AIMS: Since the recent introduction of the Case/Care Manager's professional figure, it is quite difficult to identify properly his/her own particular features, which could be mainly be found revising mainly in American studies. Therefore, the present study intended to identify the Case/Care Manager's skills and professional profile in an Intensive Care Unit experience, taking into consideration the staff's activities, perception and expectations towards the Case/Care Manager...
March 15, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28325237/global-health-in-radiation-oncology-the-emergence-of-a-new-career-pathway
#3
REVIEW
Danielle Rodin, Mei Ling Yap, Surbhi Grover, John M Longo, Onyinye Balogun, Sandra Turner, Jesper G Eriksen, C Norman Coleman, Meredith Giuliani
The massive global shortfall in radiotherapy equipment and human resources in developing countries is an enormous challenge for international efforts in cancer control. This lack of access to treatment has been long-standing, but there is now a growing consensus about the urgent need to prioritize solutions to this problem and that a global strategy is required for them to be successful. An essential element of making radiotherapy universally accessible is a coordinated approach to clinical training and practice...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28323612/from-particularities-to-context-refining-our-thinking-on-illness-narratives
#4
Annie Le, Kara Miller, Juliet McMullin
This paper examines how illness narratives are used in medical education and their implications for clinicians' thinking and care of patients. Ideally, collecting and reading illness narratives can enhance clinicians' sensitivity and contextual thinking. And yet these narratives have become part of institutionalizing cultural competency requirements in ways that tend to favor standardization. Stereotyping and reductionistic thinking can result from these pedagogic approaches and obscure structural inequities...
March 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28322463/a-tale-of-tale-prep1-pbx1-and-meis1-interconnections-and-competition-in-cancer
#5
REVIEW
Francesco Blasi, Chiara Bruckmann, Dmitry Penkov, Leila Dardaei
We report the latest structural information on PREP1 tumor suppressor, the specific "oncogene" and "tumor suppressive" signatures of MEIS1 and PREP1, the molecular rules regulating PREP1 and MEIS1 binding to DNA, and how these can change depending on the interaction with PBX1, cell-type, neoplastic transformation, and intracellular concentration. As both PREP1 and MEIS1 interact with PBX1 they functionally compete with each other. PREP1, PBX1, and MEIS1 TALE-class homeodomain transcription factors act in an interdependent and integrated way in experimental tumorigenesis...
March 21, 2017: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/28320968/numerosity-representation-is-encoded-in-human-subcortex
#6
Elliot Collins, Joonkoo Park, Marlene Behrmann
Certain numerical abilities appear to be relatively ubiquitous in the animal kingdom, including the ability to recognize and differentiate relative quantities. This skill is present in human adults and children, as well as in nonhuman primates and, perhaps surprisingly, is also demonstrated by lower species such as mosquitofish and spiders, despite the absence of cortical computation available to primates. This ubiquity of numerical competence suggests that representations that connect to numerical tasks are likely subserved by evolutionarily conserved regions of the nervous system...
March 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28319831/structure-based-prediction-of-host-pathogen-protein-interactions
#7
REVIEW
Rachelle Mariano, Stefan Wuchty
The discovery, validation, and characterization of protein-based interactions from different species are crucial for translational research regarding a variety of pathogens, ranging from the malaria parasite Plasmodium falciparum to HIV-1. Here, we review recent advances in the prediction of host-pathogen protein interfaces using structural information. In particular, we observe that current methods chiefly perform machine learning on sequence and domain information to produce large sets of candidate interactions that are further assessed and pruned to generate final, highly probable sets...
March 16, 2017: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/28319583/factor-structure-of-the-cultural-competence-items-in-the-national-home-and-hospice-care-survey
#8
Azza AbuDagga, Constance A Mara, Adam C Carle, Robert Weech-Maldonado
BACKGROUND: There is a need for validated measures of cultural competency practices in home health and hospice care (HHHC). OBJECTIVE: To establish the factor structure of the cultural competency items included in the agency-component of the 2007 public-use National Home and Hospice Care Survey file. DATA SOURCE: We used weighted survey data from 1036 HHHC agencies. RESEARCH DESIGN AND PARTICIPANTS: We used exploratory factor analyses to identify a preliminary factor structure, and then performed confirmatory factor analysis to provide further support for identified factor structure...
March 17, 2017: Medical Care
https://www.readbyqxmd.com/read/28319301/successive-charge-transitions-of-unusually-high-valence-fe-3-5-charge-disproportionation-and-intermetallic-charge-transfer
#9
Yoshiteru Hosaka, Fabio Denis Romero, Noriya Ichikawa, Takashi Saito, Yuichi Shimakawa
A perovskite-structure oxide containing unusually high-valence Fe(3.5+) was obtained by high-pressure synthesis. Instability of the Fe(3.5+) in Ca0.5 Bi0.5 FeO3 is relieved first by charge disproportionation at 250 K and then by intermetallic charge transfer between A-site Bi and B-site Fe at 200 K. These previously unobserved successive charge transitions are due to competing intermetallic and disproportionation charge instabilities. Both transitions change magnetic and structural properties significantly, indicating strong coupling of charge, spin, and lattice in the present system...
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28319202/evolving-notch-polyq-tracts-reveal-possible-solenoid-interference-elements
#10
Albert J Erives
Polyglutamine (polyQ) tracts in regulatory proteins are extremely polymorphic. As functional elements under selection for length, triplet repeats are prone to DNA replication slippage and indel mutations. Many polyQ tracts are also embedded within intrinsically disordered domains, which are less constrained, fast evolving, and difficult to characterize. To identify structural principles underlying polyQ tracts in disordered regulatory domains, here I analyze deep evolution of metazoan Notch polyQ tracts, which can generate alleles causing developmental and neurogenic defects...
2017: PloS One
https://www.readbyqxmd.com/read/28316793/development-and-validation-of-an-instrument-to-measure-collaborative-goal-setting-in-the-care-of-patients-with-diabetes
#11
Heather L Morris, Levent Dumenci, Jennifer E Lafata
OBJECTIVE: Despite known benefits of patient-perceived collaborative goal setting, we have a limited ability to monitor this process in practice. We developed the Patient Measure of Collaborative Goal Setting (PM-CGS) to evaluate the use of collaborative goal setting from the patient's perspective. RESEARCH DESIGN AND METHODS: A random sample of 400 patients aged 40 years or older, receiving diabetes care from the Virginia Commonwealth University Health System between 8/2012 and 8/2013, were mailed a survey containing potential PM-CGS items (n=44) as well as measures of patient demographics, perceived self-management competence, trust in their physician, and self-management behaviors...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28314563/a-biomechanical-approach-to-the-analysis-of-methods-and-procedures-of-bariatric-surgery
#12
Emanuele Luigi Carniel, Alessandro Frigo, Chiara Giulia Fontanella, Giulia Maria De Benedictis, Alessandro Rubini, Luca Barp, Gioela Pluchino, Beatrice Sabbadini, Lino Polese
Bariatric surgery includes a variety of procedures that are performed on obese people and aim at decreasing the intake of food and calories. This goal is usually pursued by reducing stomach capacity and/or absorbing capability. Adjustable gastric banding is the most common and successful operation. In general, bariatric surgical procedures are effective, but are often associated with major complications. Surgical procedure and post-surgical conformation of the stomach are usually defined on clinical and surgical basis only...
March 4, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28306323/a-feasibility-assessment-of-behavioral-based-interviewing-to-improve-candidate-selection-for-a-pulmonary-and-critical-care-medicine-fellowship-program
#13
Geneva Tatem, Maria Kokas, Cathy L Smith, Bruno DiGiovine
Traditional interviews for residency and fellowship training programs are an important component in the selection process, but can be of variable value due to a non-standardized approach. We redesigned the candidate interview process for our large pulmonary and critical care medicine fellowship program in the United States using a behavioral-based interview structure. The primary goal of this approach was to standardize the assessment of candidates within non-cognitive domains with the goal of selecting those with the best fit for our institution's fellowship program...
March 17, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28304259/an-extended-expectation-confirmation-model-for-mobile-nursing-information-system-continuance
#14
Pi-Jung Hsieh, Hui-Min Lai, Chen-Chung Ma, Judith W Alexander, Memg-Yi Lin
Nursing is critical in health care systems and comprises the planning, execution, and documentation of nursing care. To better manage health care information during patient care, the use of a mobile nursing information system (MNIS) provides more time to care for inpatients by reducing time-consuming and redundant paperwork. The purpose of this study was to extend the expectation-confirmation model and explore the roles of nursing professional competency (skill in use), habit (customary use), satisfaction (with use), and frequency of prior use in the context of MNIS continuance usage...
November 1, 2016: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28301761/reaction-mechanisms-on-multiwell-potential-energy-surfaces-in-combustion-and-atmospheric-chemistry
#15
David L Osborn
Chemical reactions occurring on a potential energy surface with multiple wells are ubiquitous in low-temperature combustion and in the oxidation of volatile organic compounds in Earth's atmosphere. The rich variety of structural isomerizations that compete with collisional stabilization makes characterizing such complex-forming reactions challenging. This review describes recent experimental and theoretical advances that deliver increasingly complete views of their reaction mechanisms. New methods for creating reactive intermediates coupled with multiplexed measurements provide many experimental observables simultaneously...
March 15, 2017: Annual Review of Physical Chemistry
https://www.readbyqxmd.com/read/28298442/the-short-variant-of-the-mitochondrial-dynamin-opa1-maintains-mitochondrial-energetics-and-cristae-structure
#16
Hakjoo Lee, Sylvia B Smith, Yisang Yoon
The protein optic atrophy 1 (OPA1) is a dynamin-related protein associated with the inner mitochondrial membrane, and functions in mitochondrial inner membrane fusion and cristae maintenance. Inner membrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1). It is often thought that S-OPA1 is a functionally insignificant proteolytic product of L-OPA1 because the accumulation of S-OPA1 due to L-OPA1 cleavage is observed in mitochondrial fragmentation and dysfunction. However, cells contain a mixture of both L- and S-OPA1 in normal conditions, suggesting the functional significance of maintaining both OPA1 forms, but the differential roles of L- and S-OPA1 in mitochondrial fusion and energetics are ill-defined...
March 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28297714/root-microbiota-drive-direct-integration-of-phosphate-stress-and-immunity
#17
Gabriel Castrillo, Paulo José Pereira Lima Teixeira, Sur Herrera Paredes, Theresa F Law, Laura de Lorenzo, Meghan E Feltcher, Omri M Finkel, Natalie W Breakfield, Piotr Mieczkowski, Corbin D Jones, Javier Paz-Ares, Jeffery L Dangl
Plants live in biogeochemically diverse soils with diverse microbiota. Plant organs associate intimately with a subset of these microbes, and the structure of the microbial community can be altered by soil nutrient content. Plant-associated microbes can compete with the plant and with each other for nutrients, but may also carry traits that increase the productivity of the plant. It is unknown how the plant immune system coordinates microbial recognition with nutritional cues during microbiome assembly. Here we establish that a genetic network controlling the phosphate stress response influences the structure of the root microbiome community, even under non-stress phosphate conditions...
March 15, 2017: Nature
https://www.readbyqxmd.com/read/28295814/an-evaluation-of-national-health-service-s-nhs-care-maker-programme-a-mixed-methods-analysis
#18
Kate Zubairu, Angela Christiansen, Andrew Kirkcaldy, Jennifer A Kirton, Carol Kelly, Paul Simpson, Andrea Gillespie, Jeremy Brown
AIMS: To investigate the impact and sustainability of the Care Maker programme across England from the perspective of those involved in its delivery. BACKGROUND: The Care Maker programme was launched in England in 2013. It aims to support the 'Compassion in Practice' strategy, with particular emphasis on the 6Cs of care, compassion, competence, communication, courage and commitment. Care Makers were recruited in an ambassadorial role. The intention was to inspire individuals throughout the National Health Service in England to bridge national policy with those delivering care...
March 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28295548/interaction-between-stress-induced-by-competition-predation-and-an-insecticide-on-the-response-of-aquatic-invertebrates
#19
Paul J Van den Brink, Sylvan L Klein, Andreu Rico
This study investigated effects of species interactions like competition and (intraguild) predation on the sensitivity of aquatic organisms to the insecticide chlorpyrifos. In the first experiment, combined effects of chlorpyrifos and different levels of intra- and inter-specific interaction were assessed on Gammarus pulex survival using Asellus aquaticus as an interacting species. Intra- and inter-specific interactions increased the time to extinction of G. pulex up to a factor of two, most likely due to the cannibalistic nature of G...
March 10, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28295476/the-interpersonal-work-of-dental-conscious-sedation-a-qualitative-analysis
#20
Stephen M Woolley, Barbara Chadwick, Lesley Pugsley
AIMS: Whilst there is a considerable body of literature examining the pharmacology of conscious sedation, the social tasks required to successfully provide conscious sedation have not been reported. This paper discusses data regarding the interpersonal work integral to effective conscious sedation provision, from a larger qualitative study exploring how patients and clinicians engage with secondary care conscious sedation provided within the UK. METHOD: Semi-structured interviews were conducted with 13 conscious sedation providers and nine patients within UK-based secondary care sedation settings...
March 14, 2017: Community Dentistry and Oral Epidemiology
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