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https://www.readbyqxmd.com/read/29690971/clinical-spectrum-and-outcome-of-cerebral-venous-sinus-thrombosis-in-children
#1
Iram Javed, Tipu Sultan, Zia Ur Rehman, Muhammad Rizwan Yaseen
OBJECTIVE: To determine clinical spectrum, neuroimaging finding and outcome of cerebral venous sinus thrombosis (CVST) in children. STUDY DESIGN: Descriptive and cross-sectional study. PLACE AND DURATION OF STUDY: Department of Paediatric Neurology, Children's Hospital and Institute of Child Health, Lahore, from 2015 to 2016. METHODOLOGY: Data was collected in a predesigned proforma by non-probability purposive sampling technique from all enrolled 32 patients fulfilling the inclusion criteria...
May 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29690709/-influence-of-intravenous-thrombolysis-on-prognosis-of-acute-ischemic-stroke-in-patients-with-moderate-to-severe-leukoaraiosis
#2
Y Y Liu, M Zhang, P Gao, Z X Zhang, X J Zhou, W W Yun
Objective: To investigate the influence of intravenous thrombolysis on prognosis of acute ischemic stroke in patients with moderate to severe leukoaraiosis and to analyze influencing factors of the clinical prognosis. Methods: We consecutively included acute ischemic stroke patients with middle cerebral artery occlusion ( n =101) from Department of Neurology or Emergency, and patients were divided into two groups according to whether on intravenous thrombolysis therapy (IVT) or not. The Fugl-Meyer scale score (FMS) was used to assess motor function outcome and the National Institutes of Health Stroke Scale (NIHSS) score was used to assess neurologic function...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29689584/bedside-ultrasound-guided-percutaneous-needle-aspiration-of-intra-and-extra-axial-intracranial-hemorrhage-in-neonates
#3
Mehmet N Cizmeci, Liesbeth Thewissen, Alexandra Zecic, Peter A Woerdeman, Bart de Boer, Edward Baert, Paul Govaert, Jeroen Dudink, Floris Groenendaal, Maarten Lequin, Linda S de Vries
Intracranial hemorrhage is an important cause of brain injury in the neonatal population and bedside percutaneous needle aspiration has emerged as an alternative due to the major risks that can be caused by standard neurosurgical decompression. We aimed to assess the effectiveness of this minimally invasive bedside technique and conducted a retrospective analysis of all newborn infants with a large extra-axial hemorrhage associated with a parenchymal hemorrhage causing a midline shift, managed at three academic centers over a 15-year period...
April 24, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29689406/hyperperfusion-syndrome-after-trapping-with-high-flow-bypass-for-a-giant-paraclinoid-internal-carotid-artery-aneurysm
#4
Masanao Mohri, Toshiya Ichinose, Naoyuki Uchiyama, Kouichi Misaki, Iku Nambu, Yasushi Takabatake, Mitsutoshi Nakada
BACKGROUND: Hyperperfusion syndrome associated with aneurysm surgery is rare. The occurrence of the syndrome after trapping with high-flow bypass has not been described previously. Herein, we present a case of the syndrome occurring after trapping with high-flow bypass of an unruptured giant paraclinoid internal carotid artery (ICA) aneurysm. CASE DESCRIPTION: The patient was a 68-year-old woman with progressive loss of vision in her left eye. After a diagnosis of a left giant ICA aneurysm, she underwent successful trapping with high-flow bypass...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689403/delayed-cerebral-ischemia-and-vasospasm-after-spontaneous-angiogram-negative-subarachnoid-hemorrhage-an-updated-meta-analysis
#5
Si Un Lee, Eun Pyo Hong, Bong Jun Kim, Sung-Eun Kim, Jin Pyeong Jeon
OBJECT: To provide an update on the clinical outcomes such as delayed cerebral ischemia (DCI) and vasospasm in angiogram-negative subarachnoid hemorrhage (SAH), according to hemorrhage patterns, perimesencephalic SAH (PMH) and non-PMH. METHODS: Online databases from January 1990 to December 2017 were systematically reviewed. A fixed-effect model was used to control heterogeneity. To resolve publication bias, the trim and fill method was used to estimate the number of missing studies and adjusted odds ratio (OR)...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29689391/risk-factors-for-in-hospital-seizures-and-new-onset-epilepsy-in-coil-embolization-of-aneurysmal-subarachnoid-hemorrhage
#6
Suresh K Nathan, Neel Brahme, Ahmed Kashkoush, Katherine Anetakis, Brian T Jankowitz, Parthasarathy D Thirumala
OBJECTIVE: The study aims to determine risk factors for inpatient seizures and long-term epilepsy in patients receiving coil embolization for aneurysm associated subarachnoid hemorrhage. METHODS: A retrospective chart review was conducted for patients admitted at University of Pittsburgh Medical Center from 2010 - 2014 for subarachnoid hemorrhage. Only patients with coil embolization were included. Variables such as subdural hematoma, cerebral infarction, post-operative vasospasm, cerebral edema, and mass effect were collected...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29687859/clinical-diagnosis-of-cerebral-vasospasm-after-subarachnoid-hemorrhage-by-using-transcranial-doppler-sonography
#7
D-D Li, J-Y Chang, C-X Zhou, J-B Cui
OBJECTIVE: To investigate the diagnosis of cerebral vasospasm (CVS) after subarachnoid hemorrhage (SAH) by transcranial Doppler (TCD) sonography. PATIENTS AND METHODS: 90 patients with SAH admitted to the Department of Neurosurgery of Weifang People's Hospital from January 2016 to December 2016 were selected. TCD and digital subtraction angiography (DSA) were used to diagnose the prevalence of CVS in patients. The severity of disease was evaluated (improved-Fisher grading)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29687856/granulocyte-colony-stimulating-factor-improves-neurological-function-and-angiogenesis-in-intracerebral-hemorrhage-rats
#8
S-D Liang, L-Q Ma, Z-Y Gao, Y-Y Zhuang, Y-Z Zhao
OBJECTIVE: Granulocyte colony-stimulating factor (G-CSF) plays a role in regulating phosphatidylinositol-3-kinase/serine/threonine kinase (PI3K/AKT) pathway, affecting cell proliferation and apoptosis, and inducing vascular endothelial growth factor (VEGF) expression. This study investigated the mechanism of G-CSF on angiogenesis and neural protection after intracerebral hemorrhage (ICH). MATERIALS AND METHODS: The rats were divided into four groups, including sham, ICH, ICH+G-CSF, and ICH+G-CSF+LY294002 (PI3K/AKT signaling pathway specific inhibitor)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29686642/efficacy-of-novel-carbon-nanoparticle-antioxidant-therapy-in-a-severe-model-of-reversible-middle-cerebral-artery-stroke-in-acutely-hyperglycemic-rats
#9
Roderic H Fabian, Paul J Derry, Harriett Charmaine Rea, William V Dalmeida, Lizanne G Nilewski, William K A Sikkema, Pitchaiah Mandava, Ah-Lim Tsai, Kimberly Mendoza, Vladimir Berka, James M Tour, Thomas A Kent
Introduction: While oxidative stress can be measured during transient cerebral ischemia, antioxidant therapies for ischemic stroke have been clinically unsuccessful. Many antioxidants are limited in their range and/or capacity for quenching radicals and can generate toxic intermediates overwhelming depleted endogenous protection. We developed a new antioxidant class, 40 nm × 2 nm carbon nanoparticles, hydrophilic carbon clusters, conjugated to poly(ethylene glycol) termed PEG-HCCs...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29686024/causal-impact-of-type-2-diabetes-mellitus-on-cerebral-small-vessel-disease-a-mendelian-randomization-analysis
#10
Junfeng Liu, Loes Rutten-Jacobs, Ming Liu, Hugh S Markus, Matthew Traylor
BACKGROUND AND PURPOSE: The relationship between type 2 diabetes mellitus (T2D) and cerebral small vessel disease (CSVD) is unclear. We aimed to examine the causal effect of T2D, fasting glucose levels, and higher insulin resistance on CSVD using Mendelian randomization. METHODS: Five CSVD phenotypes were studied; 2 were clinical outcomes associated with CSVD (lacunar stroke: n=2191/27 297 and intracerebral hemorrhage [ICH]: n=2254/8195 [deep and lobar ICH]), whereas 3 were radiological markers of CSVD (white matter hyperintensities: n=8429; fractional anisotropy [FA]: n=8357; and mean diffusivity: n=8357)...
April 23, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29685416/phases-score-applied-to-a-prospective-cohort-of-aneurysmal-subarachnoid-hemorrhage-patients
#11
Paul M Foreman, Philipp Hendrix, Mark R Harrigan, Winfield S Fisher, Nilesh A Vyas, Robert H Lipsky, Beverly C Walters, R Shane Tubbs, Mohammadali M Shoja, Christoph J Griessenauer
The treatment of unruptured intracranial aneurysms remains controversial. The PHASES score was developed to predict the 5-year risk of aneurysm rupture. We have assigned PHASES scores to a cohort of aneurysmal subarachnoid hemorrhage (aSAH) patients to assess the distribution of scores and its ability to predict outcome. In this study, the PHASES score was applied to a prospective cohort of aSAH patients that were enrolled in the Cerebral Aneurysm Renin Angiotensin System (CARAS) study. The CARAS study enrolled patients from two academic institutions in the United States from 2012 to 2015...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29685412/posterior-fossa-avms-increased-risk-of-bleeding-and-worse-outcome-compared-to-supratentorial-avms
#12
Nazife Dinc, Johannes Platz, Stephanie Tritt, Johanna Quick-Weller, Michael Eibach, Robert Wolff, Joachim Berkefeld, Volker Seifert, Gerhard Marquardt
Infratentorial AVMs are often considered as potentially hazardous as they are thought to present more often with hemorrhage, may harbor AVM-associated aneurysms more frequently and to be associated with poor outcome. The aim of our study is to compare features of supratentorial and infratentorial AVMs. We retrospectively analyzed 316 consecutive patients with cerebral AVM presenting to our neurovascular center between 2005 and 2015. Location and angioarchitecture of the AVM including AVM-associated aneurysms, bleeding events, and outcome during follow up were analyzed...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29685407/staged-carotid-artery-stenting-in-patients-with-severe-carotid-stenosis-multicenter-experience
#13
Dong Hyun Yoo, Hong Gee Roh, See-Sung Choi, Jusun Moon, Jeongjun Lee, Young Dae Cho, Moon Hee Han, Keun-Hwa Jung, Byung-Woo Yoon, Hyun-Seung Kang
Cerebral hyperperfusion syndrome (CHS) is serious complication after carotid artery stenting (CAS) caused by decreased cerebral vasoreactivity (CVR) due to long standing hypoperfusion of the brain. We hypothesized that partial dilatation of carotid stenosis would allow the recovery of CVR, and prevent CHS when definitive angioplasty with stent is performed afterward. In this study, we aimed to evaluate the safety and efficacy of staged CAS in patients with severe carotid artery stenosis with evident hemodynamic compromise in regard to preventing hyperperfusion syndrome...
April 20, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29684516/reconsideration-of-neurogenic-pulmonary-oedema-as-a-source-of-metastatic-cerebral-abscess-following-subarachnoid-hemorrhages-a-preliminary-study
#14
Ahmet Gökyar, Mehmet D Aydın, Sevilay Özmen, Elif Demirci, Abdullah H Marangoz, Enis Kuruoğlu, Cengiz Çokluk
BACKGROUND: Subarachnoid hemorrhage (SAH) may be a cause of neurogenic pulmonary edema (NPE). It is well known that lymphatic fluid draining by thoracic duct to lungs consists of many dangerous metabolites, degraded tissue particles and microbiological pathogens. However, there is no enough study which investigates if NPE cause septicemia or not. In this study, we retrospectively examined our experimental materials whether there is a meaningful relationship between the NPE and cerebral abscess formation...
April 20, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29683965/effect-of-dexmedetomidine-on-cerebral-vasospasm-and-associated-biomarkers-in-a-rat-subarachnoid-hemorrhage-model
#15
Young Song, Beom Jin Lim, Do-Hyeong Kim, Jin Woo Ju, Dong Woo Han
BACKGROUND: The α2 adrenergic agonist dexmedetomidine (DEX) has huge potential for protecting against cerebral vasospasm, a leading cause of death and disability after subarachnoid hemorrhage (SAH). Biomarker assays for SAH have recently emerged as tools for predicting vasospasm and outcomes. We investigated the effects of DEX on vasospasm and assessed relevant biomarkers in a rat SAH model. METHODS: Male Wistar rats were randomly assigned to sham (n=10), vehicle (n=10), SAH (n=10), or SAH+ DEX (n=10) groups...
April 20, 2018: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/29682077/intracerebral-hemorrhage-with-multiple-intracranial-arterial-stenoses-in-a-synthetic-cannabinoid-spice-user
#16
Seckin Aydin, Odhan Yuksel, Aysegul Esen Aydin, Osman Kizilkilic, Suat Erol Celik
Synthetic cannabinoids (spice), which are used frequently worldwide, are more potent than herbal compounds and also have more side effects in comparison. A 23-year-old male was admitted to the emergency unit with altered consciousness. There was no sign of trauma, and his medical history did not reveal any chronic illness. Computed tomography revealed a large frontal hematoma extending to the ventricular system. The outcomes of cerebral angiography were consistent with multiple intracranial arterial stenoses (MIAS) which can also be seen after cannabis usage...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682069/ruptured-distal-anterior-choroidal-artery-aneurysm-presenting-as-isolated-intraventricular-hemorrhage-case-report-and-comprehensive-review-of-the-literature
#17
Chi Hau Tan, Leon T Lai, Ronil V Chandra
Distal anterior choroidal artery (AChA) aneurysms are infrequent. We discuss the case of a 59-year-old patient who presented with an isolated intraventricular hemorrhage (IVH) secondary to a ruptured distal AChA aneurysm. Initial noninvasive cerebral computed tomography angiography revealed no evidence of an underlying vascular pathology. The patient underwent further digital subtraction cerebral angiography, which revealed an aneurysm arising from the distal AChA segment. The aneurysm was successfully treated with surgical clip ligation...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682058/hemispheric-infarct-following-a-cerebellar-hematoma-a-rare-coincidence
#18
R Girish Menon, Vinod Kumar, I K Laskhman, Rajesh P Nair
Concomitant cerebral infarction developing soon after a parenchymal intracerebral hemorrhage is a rare occurrence. Usually, these remote site changes follow tumor decompression and are associated with hemorrhagic changes rather than infarcts. We report a case of a fatal malignant internal carotid territory infarct in a hospitalized patient being conservatively managed for a vermian hematoma and discuss the probable pathophysiology. Stroke physicians need to be aware that spontaneous intracerebral hematoma patients have a potential threat of developing large vessel occlusion with malignant cerebral infarcts, especially after surgical decompression...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682020/morphometric-analysis-of-dose-dependent-effect-of-progesterone-on-experimental-vasospasm-induced-rat-femoral-arteries
#19
Metin Kasap, Huseyin Canaz, Gokhan Canaz, Mehmet Tokmak, Alper Bingul, Ibrahim Alatas
Objective: Our aim of this study was to determine effective doses of progesterone which has a vasodilatory effect during the early stage of vasospasm. Cerebral vasospasm (CV) is a predominant cause of morbidity and mortality which develops following subarachnoidal hemorrhage (SAH). Etiopathogenesis of CV is multifactorial. Despite many previously performed studies on this issue, the mechanism by which blood and blood products in the subarachnoidal space induce CV has not been clarified yet...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682015/spinal-cerebrospinal-fluid-drainage-for-prevention-of-vasospasm-in-aneurysmal-subarachnoid-hemorrhage-a-prospective-randomized-controlled-study
#20
Sachin Anil Borkar, Manmohanjit Singh, Shashank Sharad Kale, Ashish Suri, Poodipedi Sarat Chandra, Rajender Kumar, Bhawani Shankar Sharma, Shailesh Gaikwad, Ashok Kumar Mahapatra
Introduction: Cerebral vasospasm following aneurysmal subarachnoid hemorrhage (SAH) is a major cause of mortality and morbidity. Despite various treatment modalities, the optimal management of vasospasm remains elusive. In this regard; we undertook a prospective, randomized controlled study to evaluate the effectiveness of lumbar cerebrospinal fluid drainage (LCSFD) for prevention of cerebral vasospasm and its sequelae. Materials and Methods: Patients with aneurysmal SAH who met the inclusion criteria were randomized into two groups - Group I (30 patients) underwent LCSFD whereas Group II (30 patients) did not undergo LCSFD...
April 2018: Asian Journal of Neurosurgery
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