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Personality, risk factor, drug abuse,

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https://www.readbyqxmd.com/read/28666811/%C3%AE-6%C3%AE-2-subunit-containing-nicotinic-acetylcholine-receptors-exert-opposing-actions-on-rapid-dopamine-signaling-in-the-nucleus-accumbens-of-rats-with-high-versus-low-response-to-novelty
#1
Cody A Siciliano, J Michael McIntosh, Sara R Jones, Mark J Ferris
Determining neurobiological factors that contribute to individual variance in drug addiction vulnerability allows for identification of at-risk populations, use of preventative measures and personalized medicine in the treatment of substance use disorders. Rodents that exhibit high locomotor activity when exploring an inescapable novel environment (high-responder; HR) are more susceptible to the reinforcing effects of many abused compounds, including nicotine, as compared to animals that exhibit low locomotor activity (low-responder; LR)...
June 27, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28660681/the-role-of-affective-temperament-as-a-predictor-of-relapse-in-alcohol-dependence
#2
Sofia Paulino, Samuel Pombo, Fátima Ismail, Maria Luísa Figueira, Otto Lesch
BACKGROUND: Personality traits have been proposed as relapse risk factors in alcohol use disorders. So far, no study has assessed the association between affective temperamental traits and the prospective relapse risk. METHODS: This was a 3-month prospective naturalistic study, designed to assess the impact of affective temperaments in relapse. A sample of 61 alcohol-dependent patients was collected from an ambulatory clinical setting. Socio-demographic information, drinking and substance use habits, drinking status, craving and affective temperament traits were assessed...
June 29, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28602472/neglect-educational-success-and-young-people-in-out-of-home-care-cross-sectional-and-longitudinal-analyses
#3
Nicholas G Tessier, Aoife O'Higgins, Robert J Flynn
Maltreated young persons in out-of-home care often have poor educational outcomes, heightening their risk of long-term psychosocial disadvantage (Forsman, Brännström, Vinnerljung, & Hjern, 2016). In their systematic reviews, Romano, Babchishin, Marquis, and Fréchette (2014) and O'Higgins, Sebba, and Gardner (in press) found evidence that neglect was more often linked with low academic achievement, whereas abuse was more likely to be associated with behavioral difficulties. In large samples of young persons in out-of-home care in Ontario, Canada, who had experienced mainly neglect, we investigated risk and protective factors as predictors of educational success...
June 8, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28599210/long-term-recall-of-social-relationships-related-to-addiction-and-hiv-risk-behaviors
#4
R L Stout, T Janssen, J M Braciszewski, A Vose-O'Neal
BACKGROUND: Social relationships have been demonstrated as a key predictor of relapse among addicted persons and are likely to be important determinants of HIV risk behaviors also. However, the degree to which this population can reliably and consistently identify important people (IPs) in retrospect has been understudied. METHODS: Using the modified Important People and Activities questionnaire, we investigated to what degree IPs were dropped, added, or retained, and whether data about individual IPs were reported accurately on 6- and 12-month follow up periods using a sample of 50 drug or alcohol abusing participants...
August 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28492958/psychometric-validation-of-the-posit-for-screening-alcohol-and-other-drugs-risk-consumption-among-adolescents
#5
Manuel Araujo, Sandra Golpe, Teresa Braña, Jesús Varela, Antonio Rial
Early detection of alcohol and drug abuse among adolescents is decisive not only for rapid referral and intervention in cases of risk, but also as an indicator for use in the evaluation of prevention programs and public policies to reduce consumption. One of the most widely-used screening instruments in the world is the Problem Oriented Screening Instrument for Teenagers (POSIT) (Rahdert, 1991), whose substance use and abuse subscale (POSITUAS) is a brief tool of enormous applied potential. However, there is still no empirical validation study that would ensure its good psychometric performance in Spain...
July 14, 2017: Adicciones
https://www.readbyqxmd.com/read/28491887/risk-factors-for-surgical-site-infection-after-cholecystectomy
#6
David K Warren, Katelin B Nickel, Anna E Wallace, Daniel Mines, Fang Tian, William J Symons, Victoria J Fraser, Margaret A Olsen
BACKGROUND: There are limited data on risk factors for surgical site infection (SSI) after open or laparoscopic cholecystectomy. METHODS: A retrospective cohort of commercially insured persons aged 18-64 years was assembled using International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) procedure or Current Procedural Terminology, 4th edition codes for cholecystectomy from December 31, 2004 to December 31, 2010. Complex procedures and patients (eg, cancer, end-stage renal disease) and procedures with pre-existing infection were excluded...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28428763/adhd-lifestyles-and-comorbidities-a-call-for-an-holistic-perspective-from-medical-to-societal-intervening-factors
#7
REVIEW
Simon Weissenberger, Radek Ptacek, Martina Klicperova-Baker, Andreja Erman, Katerina Schonova, Jiri Raboch, Michal Goetz
The review examines Attention Deficit Hyperactivity Disorder (ADHD in its Child and Adult form) and its various presentations (Hyperactive Impulsive, Inattentive, and Combined) with a particular focus on environmental (incl. social factors), lifestyles and comorbidities. It is argued that ADHD is best understood in a holistic and interactive context and a vast empirical literature is presented to illustrate the point: Environmental factors include stress in general as well as exposure to toxins (phthalates, bisphenol A)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28405265/socio-epidemiologic-aspects-and-cutaneous-side-effects-of-permanent-tattoos-in-germany-tattoos-are-not-restricted-to-a-specific-social-phenotype
#8
Cornelia Sigrid Lissi Müller, Angela Oertel, Rebecca Körner, Claudia Pföhler, Thomas Vogt
Background: More and more people of all age classes have a tattoo. Intriguingly, there are multiple prejudices in the general population and published data that concern tattooed persons, such as being criminals, having a low education, being alcohol or drug abusers, or more risky in their life style. Objective: To obtain and to evaluate sociodemographic data on tattooed persons, to investigate the incidence of tattoo-related cutaneous complications and to define personal risk factors and course of the persons after being tattooed concerning behavior of personal environment...
2017: Dermato-endocrinology
https://www.readbyqxmd.com/read/28280383/nurses-and-opioids-results-of-a-bi-national-survey-on-mental-models-regarding-opioid-administration-in-hospitals
#9
Charlotte Guest, Fabian Sobotka, Athina Karavasopoulou, Stephen Ward, Carsten Bantel
OBJECTIVE: Pain remains insufficiently treated in hospitals. Increasing evidence suggests human factors contribute to this, due to nurses failing to administer opioids. This behavior might be the consequence of nurses' mental models about opioids. As personal experience and conceptions shape these models, the aim of this prospective survey was to identify model-influencing factors. MATERIAL AND METHODS: A questionnaire was developed comprising of 14 statements concerning ideations about opioids and seven questions concerning demographics, indicators of adult learning, and strength of religious beliefs...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28252529/immunodeficiency-aids-related-pneumonia-and-risk-of-lung-cancer-among-hiv-infected-individuals
#10
Julia L Marcus, Wendy A Leyden, Chun R Chao, Michael A Horberg, Daniel B Klein, Charles P Quesenberry, William J Towner, Michael J Silverberg
OBJECTIVE: The objective is to clarify the role of immunodeficiency and pneumonia in elevated lung cancer risk among HIV-infected individuals. DESIGN: Cohort study of HIV-infected and HIV-uninfected adults in a large integrated healthcare system in California during 1996-2011. METHODS: We used Poisson models to obtain rate ratios for lung cancer associated with HIV infection, overall and stratified by recent CD4 cells/μl (HIV-uninfected as reference group), with χ tests for trends across CD4 strata...
April 24, 2017: AIDS
https://www.readbyqxmd.com/read/28241797/changes-in-mortality-rates-and-causes-of-death-in-a-population-based-cohort-of-persons-living-with-and-without-hiv-from-1996-to-2012
#11
Oghenowede Eyawo, Conrado Franco-Villalobos, Mark W Hull, Adriana Nohpal, Hasina Samji, Paul Sereda, Viviane D Lima, Jeannie Shoveller, David Moore, Julio S G Montaner, Robert S Hogg
BACKGROUND: Non-HIV/AIDS-related diseases are gaining prominence as important causes of morbidity and mortality among people living with HIV. The purpose of this study was to characterize and compare changes over time in mortality rates and causes of death among a population-based cohort of persons living with and without HIV in British Columbia (BC), Canada. METHODS: We analysed data from the Comparative Outcomes And Service Utilization Trends (COAST) study; a retrospective population-based study created via linkage between the BC Centre for Excellence in HIV/AIDS and Population Data BC, and containing data for HIV-infected individuals and the general population of BC, respectively...
February 27, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28236511/do-patient-characteristics-moderate-the-effect-of-extended-release-naltrexone-xr-ntx-for-opioid-use-disorder
#12
Peter D Friedmann, Donna Wilson, Edward V Nunes, Randall Hoskinson, Joshua D Lee, Michael Gordon, Sean M Murphy, Richard J Bonnie, Donna T Chen, Tamara Y Boney, Charles P O'Brien
BACKGROUND: Extended release naltrexone (XR-NTX) injected intramuscularly monthly has been shown to reduce relapse in persons with opioid use disorder. Baseline factors, including patients' demographics, comorbidities and lifestyle, may help identify patients who will benefit most or least from XR-NTX treatment. METHODS: Potential moderators of XR-NTX's effect were examined in the largest North American randomized open-label effectiveness trial of XR-NTX. Relapse status (Yes/No) at 6-month follow-up was regressed on treatment group (XR-NTX, N=153; or Treatment-as-Usual [TAU], N=155), baseline covariates, and their two-way interaction to identify moderator effects...
February 21, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28228053/hiv-related-pneumococcal-disease-prevention-in-adults
#13
REVIEW
Charles Feldman, Ronald Anderson, Theresa Rossouw
HIV-infected persons are particularly susceptible to the development of severe pneumococcal disease, even in the setting of combination antiretroviral therapy (cART), due to slow, incomplete recovery of anti-pneumococcal host defenses. This risk is increased by avoidable aspects of lifestyle, particularly smoking, which intensify immunosuppression. Clearly, more effective preventive measures are needed to counter this threat. Areas covered: This is a detailed review of the published literature focusing on currently available strategies for prevention of pneumococcal infection in HIV-infected patients, including cotrimoxazole prophylaxis, cART, pneumococcal vaccination, and smoking cessation strategies...
March 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28188400/-juvenile-stroke-what-is-important
#14
M Fischer, B Eckert, J Röther
Stroke in young adults is a diagnostic and therapeutic challenge for all persons involved. Approximately 15% of ischemic strokes occur in young adults. Lack of awareness of the symptoms in emergency departments often results in delayed diagnosis and access to specific therapeutic options, such as revascularization. The causes are often heterogeneous and necessitate specific investigations. The etiology of juvenile stroke includes drug abuse, vasculitis and arteriopathies, such as reversible vasoconstriction syndrome and posterior reversible encephalopathy syndrome, although the prevalence of classical vascular risk factors is high...
February 10, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28165441/intravenous-drugs-abuse-as-the-main-risk-factor-of-increasing-hepatitis-c-infection-prevalence-in-prisoners-in-zenica-bosnia-and-herzegovina
#15
Harun Hodžić, Amel Bajramović, Zarema Obradović, Mersiha Mahmić-Kaknjo
Aim To determine the prevalence of hepatitis C virus infection (HCV) among prisoners in Zenica prison, and to investigate the relation between HCV and risky behaviors: intravenous drugs use (IDU), tattooing, promiscuity. Methods This cross-sectional study conducted at the High Security Penitentiary in Zenica involved 200 convicted persons who gave their consents for the research. Their blood was tested by AraGen Hepatitis C Test. Risky behaviors (IDU, tattooing, promiscuity) were tested by an anonymous self-administered questionnaire...
February 1, 2017: Medicinski Glasnik
https://www.readbyqxmd.com/read/28077602/diagnoses-of-sexual-abuse-and-their-common-registered-comorbidities-in-the-total-population-of-stockholm
#16
Gita Rajan, Gunnar Ljunggren, Per Wändell, Lars Wahlström, Carl-Göran Svedin, Axel C Carlsson
BACKGROUND: Prior research based on self-reports has proven sexual abuse to be a risk factor for pain and psychiatric disorders. However, less is known about how this is reflected within the healthcare system. The aim of this study was to study the 2-year prevalence of diagnosis of sexual abuse and concomitant conditions. METHODS: Using data from VAL, the study population included all living persons in Stockholm County, Sweden, between 1 January 2008 and 31 December 2014 (N=2 549 496)...
January 11, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28017185/failure-to-get-into-substance-abuse-treatment
#17
Dennis G Fisher, Grace L Reynolds, Laura H D'Anna, David W Hosmer, Kholoud Hardan-Khalil
Among substance abusers in the US, the discrepancy in the number who access substance abuse treatment and the number who need treatment is sizable. This results in a major public health problem of access to treatment. The purpose of this study was to examine characteristics of Persons Who Use Drugs (PWUDs) that either hinder or facilitate access to treatment. 2646 participants were administered the Risk Behavior Assessment (RBA) and the Barratt Impulsiveness Scale. The RBA included the dependent variable which was responses to the question "During the last year, have you ever tried, but been unable, to get into a drug treatment or detox program?" In multivariate analysis, factors associated with being unable to access treatment included: Previously been in drug treatment (OR=4...
February 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28013099/gender-differences-in-substance-abuse-ptsd-and-intentional-self-harm-among-veterans-health-administration-patients
#18
Jaimie L Gradus, Sarah Leatherman, Andrew Curreri, Lisa G Myers, Ryan Ferguson, Matthew Miller
BACKGROUND: Epidemiologic studies have reported substance abuse and posttraumatic stress disorder (PTSD) diagnoses as risk factors for suicide among Veterans Health Administration (VHA) patients. Research on risk factors for suicide may not generalize to our understanding of non-fatal intentional self-harm (ISH), given the evidence that these outcomes have unique risk factors. The aims of this study were to examine (1) gender-stratified rates of non-fatal ISH in VHA patients with alcohol abuse/dependence, drug abuse/dependence, and PTSD and (2) gender-stratified interaction between alcohol abuse and dependence and drug abuse and dependence and PTSD in predicting non-fatal ISH...
November 21, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27907114/rates-and-predictors-of-non-adherence-to-antiretroviral-therapy-among-hiv-positive-individuals-in-kenya-results-from-the-second-kenya-aids-indicator-survey-2012
#19
Irene N Mukui, Lucy Ng'ang'a, John Williamson, Joyce N Wamicwe, Shobha Vakil, Abraham Katana, Andrea A Kim
INTRODUCTION: Understanding the levels and associated factors of non-adherence to antiretroviral therapy (ART) is crucial in designing interventions to improve adherence and health outcomes of ART. We assessed non-adherence to ART among HIV-infected persons reporting ART use in a nationally representative survey in Kenya. METHODS: The Kenya AIDS Indicator Survey 2012 was a population-based, household survey of persons aged 18 months-64 years conducted in 2012-2013...
2016: PloS One
https://www.readbyqxmd.com/read/27866392/drug-caused-deaths-in-australian-medical-practitioners-and-health-care-professionals
#20
Jennifer L Pilgrim, Rhyse Dorward, Olaf H Drummer
BACKGROUND AND AIMS: There are numerous factors putting health-care professionals (HCP) at a higher risk of substance abuse and premature death, including high-stress jobs, access to controlled substances, long hours of practice and constant contact with the critically ill. This study aimed to examine fatal drug toxicity in this high-risk cohort, in order to: (1) estimate the rate of drug-caused deaths of Australian HCPs; (2) describe the key characteristics of the cohort; and (3) examine the relationship between HCP occupation and drug type, or intent...
March 2017: Addiction
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