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Microwave Ablation

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https://www.readbyqxmd.com/read/28643305/-interventional-therapy-of-colorectal-liver-metastasis
#1
Qi Zhang, Gaojun Teng
Colorectal liver metastasis (CRLM) is one of the most difficult and key points in the treatment of colorectal cancer. Approximately 50% to 60% of patients diagnosed as colorectal cancer develops metastasis, and 80% to 90% of CRLM is unresectable. Surgical resection is the first-line treatment for CRLM, while it is only suitable for about 15% patients. Systemic chemotherapy can prolong the survival of CRLM patients, however, a part of CRLM patients are resistant to chemotherapy. With the development of technology and the update of clinical evidence, individual therapy with target drugs and multidisciplinary treatment (MDT) have became a tendency, and minimally invasive interventional therapy has gained more acceptance in the MDT mode of the treatment for CRLM...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28641464/ultrasound-guided-hydrodissection-for-assisting-percutaneous-microwave-ablation-of-renal-cell-carcinomas-adjacent-to-intestinal-tracts-a-preliminary-clinical-study
#2
Zhigang Cheng, Xiaoling Yu, Zhiyu Han, Fangyi Liu, Jie Yu, Ping Liang
PURPOSE: To evaluate the safety and efficacy of the clinical application of hydrodissection under ultrasound (US) guidance for assisting percutaneous microwave ablation (MWA) for the treatment of renal cell carcinomas (RCCs) adjacent to the intestinal tract. MATERIALS AND METHODS: From April 2014 to December 2016, clinical data from 24 patients with 25 RCCs were retrospectively analysed. Percutaneous MWA under the assistance of US-guided hydrodissection were performed to treat RCCs with a mean maximal diameter of 3...
June 22, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28640198/experimental-investigation-of-magnetic-nanoparticle-enhanced-microwave-hyperthermia
#3
Brogan T McWilliams, Hongwang Wang, Valerie J Binns, Sergio Curto, Stefan H Bossmann, Punit Prakash
The objective of this study was to evaluate microwave heating enhancements offered by iron/iron oxide nanoparticles dispersed within tissue-mimicking media for improving efficacy of microwave thermal therapy. The following dopamine-coated magnetic nanoparticles (MNPs) were considered: 10 and 20 nm diameter spherical core/shell Fe/Fe₃O₄, 20 nm edge-length cubic Fe₃O₄, and 45 nm edge-length/10 nm height hexagonal Fe₃O₄. Microwave heating enhancements were experimentally measured with MNPs dissolved in an agar phantom, placed within a rectangular waveguide...
June 22, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28635405/effects-of-microwave-ablation-on-t-cell-subsets-and-cytokines-of-patients-with-hepatocellular-carcinoma
#4
Haiwen Zhang, Xiaowei Hou, Hongjian Cai, Xingjun Zhuang
OBJECTIVES: To investigate the effects of microwave ablation on T-lymphocyte subsets and cytokines in patients with hepatocellular carcinoma. MATERIAL AND METHODS: Peripheral blood was collected from 45 patients with hepatocellular carcinoma treated by microwave ablation before treatment, one week and one month after treatment. T cells (CD3+, CD4+ and CD8+ cells), CD4+ CD25+ Tregs, and CD16+ CD56+ NK cells were analyzed by flow cytometry. Levels of cytokines (IL-2, IFN-γ, TNF-α, IL-12, IL-4, IL-6, IL-8, and IL-10) were determined by a Luminex 200 analyzer...
February 20, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28632268/ball-in-ball-zro2-nanostructure-for-simultaneous-ct-imaging-and-highly-efficient-synergic-microwave-ablation-and-tri-stimuli-responsive-chemotherapy-of-tumors
#5
Dan Long, Meng Niu, Longfei Tan, Changhui Fu, Xiangling Ren, Ke Xu, Hongshan Zhong, Jingzhuo Wang, Laifeng Li, Xianwei Meng
Combined thermo-chemotherapy displays outstanding synergically therapeutic efficiency when compared with standalone thermotherapy and chemotherapy. Herein, we developed a smart tri-stimuli-responsive drug delivery system involving X@BB-ZrO2 NPs (X represents loaded IL, DOX, keratin and tetradecanol) based on novel ball-in-ball-structured ZrO2 nanoparticles (BB-ZrO2 NPs). The microwave energy conversion efficiency of BB-ZrO2 NPs was 41.2% higher than that of traditional single-layer NPs due to the cooperative action of self-reflection and spatial confinement effect of the special two-layer hollow nanostructure...
June 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28629577/comparison-of-ultrasonography-guided-percutaneous-microwave-ablation-for-subcapsular-and-nonsubcapsular-hepatocellular-carcinoma
#6
Fangyi Liu, Xiaoling Yu, Zhigang Cheng, Zhiyu Han, Ya Sun, Ping Liang, Fubo Zhou
PURPOSE: To compare the prognosis of subcapsular and nonsubcapsular hepatocellular carcinoma (HCC) after ultrasonography (US)-guided percutaneous microwave ablation (MWA). MATERIALS AND METHODS: From January 2012 to December 2015, 463 enrollment patients (382 men, 81 women; age range, 24-95 years) with a single HCC underwent US-guided percutaneous MWA. The patients were divided into two groups according to tumor location: subcapsular (n=224) and nonsubcapsular (n=239)...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28613203/-renal-tumors-percutaneous-ablation-by-microwave-initial-experience
#7
Juan Sebastian Toro-Gutierrez, Juan Jose Espejo-Herrero, Maria Sagrario Lombardo-Galera, Maria Eugenia Pérez-Montilla, Miguel Canis-López, Luis Zurera-Tendero, Juan Manuel Rubio
OBJECTIVE: To analyze retrospectively the safety and effectiveness of percutaneous microwave ablation of solid renal tumors, and also review different approach techniques. METHODS: It is a retrospective study approved by the ethics committee of both hospitals. 14 tumors with a mean size of 37 mm (12-50 mm) were treated in a single session, under general anesthesia and with CT guidance, in 14 patients (9 men) with a mean age of 66 years, using the ablation system AMICA by different approaches (trans pulmonary, trans peritoneal and retroperitoneal)...
June 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28612019/thermal-ablation-in-the-management-of-colorectal-cancer-patients-with-oligometastatic-liver-disease
#8
REVIEW
Elena Nadia Petre, Constantinos Sofocleous
BACKGROUND: Surgical resection of limited colorectal liver disease improves long-term survival and can be curative in a subset of selected cases. Image-guided percutaneous ablation therapies have emerged as safe and effective alternative options for selected patients with unresectable colorectal liver metastases (CLM) that can be ablated with margins. Ablation causes focal destruction of tissue and has increasingly been shown to provide durable eradication of tumors. METHODS: A selective review of literature was conducted in PubMed, focusing on recent studies reporting on the safety, efficacy, and long-term outcomes of percutaneous ablation modalities in the treatment of CLM...
March 2017: Visceral Medicine
https://www.readbyqxmd.com/read/28611285/ultrasound-guided-percutaneous-microwave-ablation-of-benign-breast-lesions
#9
Jie Yu, Bao-Hua Chen, Jing Zhang, Han Wu, Yan Huang, Meng-Juan Mu, Ping Liang
The benign breast lesions (BBLs) share a high incidence for women and therapy methods with minimal invasion and better cosmetic outcome are thirsted for. In this study, 122 patients with 198 biopsy-proved BBLs were enrolled. Ultrasound (US)-guided microwave ablation (MWA) was performed with local anesthesia from November, 2013 to April, 2016. The mean longest tumor size assessed was 1.6±0.7 cm (ranging 0.7-4.9 cm). MWA was successfully performed in all cases including 85 lesions adjacent to the skin, pectoralis and areola...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28599296/microwave-ablation-combined-with-egfr-tkis-versus-only-egfr-tkis-in-advanced-nsclc-patients-with-egfr-sensitive-mutations
#10
Zhigang Wei, Xin Ye, Xia Yang, Aimin Zheng, Guanghui Huang, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Yang Ni
We conducted this retrospective study to investigate whether microwave ablation (MWA) of primary tumor sites plus epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) could improve survival in advanced non small cell lung cancer (NSCLC) with EGFR mutations. MWA was conducted at the primary tumor sites, followed by EGFR-TKIs in the MWA plus EGFR-TKIs group. EGFR-TKIs were administered until disease progression or intolerable toxicity. The primary endpoint was progression-free survival (PFS); secondary endpoints were overall survival (OS) and objective response rate (ORR)...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28595851/delineation-of-post-procedure-ablation-regions-with-electrode-displacement-elastography-with-a-comparison-to-acoustic-radiation-force-impulse-imaging
#11
Wenjun Yang, Tomy Varghese, Timothy Ziemlewicz, Marci Alexander, Meghan Lubner, James Louis Hinshaw, Shane Wells, Fred T Lee
We compared a quasi-static ultrasound elastography technique, referred to as electrode displacement elastography (EDE), with acoustic radiation force impulse imaging (ARFI) for monitoring microwave ablation (MWA) procedures on patients diagnosed with liver neoplasms. Forty-nine patients recruited to this study underwent EDE and ARFI with a Siemens Acuson S2000 system after an MWA procedure. On the basis of visualization results from two observers, the ablated region in ARFI images was recognizable on 20 patients on average in conjunction with B-mode imaging, whereas delineable ablation boundaries could be generated on 4 patients on average...
June 5, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28588777/the-combination-of-systemic-chemotherapy-and-local-treatment-may-improve-the-survival-of-patients-with-unresectable-metastatic-colorectal-cancer
#12
Jiemin Zhao, Liangrong Shi, Mei Ji, Jun Wu, Changping Wu
With the development of systemic chemotherapy, the survival time of patients with advanced colorectal cancer (CRC) has increased. In addition, local treatments, such as microwave ablation and radioactive seed implantation, have been shown to be effective. However, the number of studies reporting on the effect of systemic chemotherapy combined with local treatments is limited. The present study was conducted to determine the effect of local treatment combined with systemic chemotherapy in patients with initial unresectable metastatic CRC (mCRC)...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28579685/decision-making-in-interventional-oncology-ablative-options-in-the-lung
#13
REVIEW
Kyungmouk Steve Lee, Joseph P Erinjeri
Image-guided ablation is safe and effective for the treatment of both primary and metastatic tumors in the lung. This article reviews the three most commonly used ablative options: radiofrequency ablation, microwave ablation, and cryoablation. We describe the advantages of each ablation modality in the lung and how to choose the most appropriate ablation device based on patient and tumor characteristics. The optimal technique for lung ablation is discussed and technical tips for improving clinical outcome are described...
June 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28579684/decision-making-thermal-ablation-options-for-small-renal-masses
#14
REVIEW
Colin J McCarthy, Debra A Gervais
Renal cell carcinoma is a relatively common tumor, with an estimated 63,000 new cases being diagnosed in the United States in 2016. Surgery, be it with partial or total nephrectomy, is considered the mainstay of treatment for many patients. However, those patients with small renal masses, typically less than 3 to 4 cm in size who are deemed unsuitable for surgery, may be suitable for percutaneous thermal ablation. We review the various treatment modalities, including radiofrequency ablation, microwave ablation, and cryoablation; discuss the advantages and disadvantages of each method; and review the latest data concerning the performance of the various ablative modalities compared with each other, and compared with surgery...
June 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28572150/percutaneous-spinal-ablation-in-a-sheep-model-protective-capacity-of-an-intact-cortex-correlation-of-ablation-parameters-with-ablation-zone-size-and-correlation-of-postablation-mri-and-pathologic-findings
#15
A N Wallace, T J Hillen, M V Friedman, Z S Zohny, B H Stephens, S C Greco, M R Talcott, J W Jennings
BACKGROUND AND PURPOSE: Despite the growing use of percutaneous ablation therapy for the treatment of metastatic spine disease, several issues have yet to be fully addressed. Our aims were to determine whether the vertebral body cortex protects against ablation-induced spinal cord injury; correlate radiofrequency, cryo-, and microwave ablation parameters with resulting spinal ablation zone dimensions and describe normal spinal marrow postablation changes on MR imaging. MATERIALS AND METHODS: Ten thoracolumbar vertebrae in 3 sheep were treated with radiofrequency ablation, cryoablation, or microwave ablation under fluoroscopic guidance...
June 1, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28571327/the-covalent-interaction-between-dihydrogen-and-gold-a-rotational-spectroscopic-study-of-h2-aucl
#16
Daniel A Obenchain, Derek S Frank, G S Grubbs, Herbert M Pickett, Stewart E Novick
The pure rotational transitions of H2-AuCl have been measured using a pulsed-jet cavity Fourier transform microwave spectrometer equipped with a laser ablation source. The structure was found to be T-shaped, with the H-H bond interacting with the gold atom. Both (35)Cl and (37)Cl isotopologues have been measured for both ortho and para states of H2. Rotational constants, quartic centrifugal distortion constants, and nuclear quadrupole coupling constants for gold and chlorine have been determined. The use of the nuclear spin-nuclear spin interaction terms Daa, Dbb, and Dcc for H2 were required to fit the ortho state of hydrogen, as well as a nuclear-spin rotation constant Caa...
May 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28560833/use-of-microwave-ablation-in-the-treatment-of-patients-with-multiple-primary-malignant-tumors
#17
Yue Han, Na Shao, Xiaoming Xi, Xuezhi Hao
A 56-year-old man was admitted to our hospital in 2007, complaining of an irritating cough. Computed tomography examination demonstrated a mass in the right lung and enlargement of the hilar and mediastinal lymph nodes. Small cell lung cancer was confirmed by pathological examination after fibro-bronchoscope biopsy. The patient was treated with received sequential chemotherapy and radiotherapy. Preventive radiotherapy of the whole brain was performed after complete remission of the lung disease. Seven years after diagnosis, follow-up computed tomography revealed masses in both the liver and kidney...
May 31, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28559824/microwave-ablation-and-immune-activation-in-the-treatment-of-recurrent-colorectal-lung-metastases-a-case-report
#18
Magnus Bäcklund, Jacob Freedman
We present a patient with colorectal metastases confined to the lungs and treated with multiple resections until this was not an option anymore, followed by stereotactic body radiation therapy until this option was drained. Then, the patient was successfully treated with multiple microwave ablations combined with immunological activation targeting the programmed cell death 1 receptor (PD-1), possibly instigating a powerful abscopal effect. Techniques, doses, and radiological findings are presented.
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28545682/percutaneous-microwave-ablation-of-renal-cancers-under-ct-guidance-safety-and-efficacy-with-a-2-year-follow-up
#19
P Chan, S Vélasco, G Vesselle, S Boucebci, G Herpe, B Debaene, P Ingrand, J Irani, J-P Tasu
AIM: To evaluate the safety and efficiency of percutaneous microwave ablation (MWA) of renal cell carcinomas (RCC) carried out under computed tomography (CT) guidance. MATERIALS AND METHODS: A retrospective study was performed on RCC that was either histologically proven or diagnosed at imaging (Bosniak IV cyst) and treated by MWA under general anaesthesia with CT guidance. Indications for percutaneous ablation were based on the American Urological Association recommendations...
May 22, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28543540/computational-modeling-of-915-mhz-microwave-ablation-comparative-assessment-of-temperature-dependent-tissue-dielectric-models
#20
Garron Deshazer, Mark Hagmann, Derek Merck, Jan Sebek, Kent B Moore, Punit Prakash
PURPOSE: The objective of this study is to develop a computational model for simulating 915 MHz microwave ablation (MWA), and verify the simulation predictions of transient temperature profiles against experimental measurements. Due to the limited experimental data characterizing temperature-dependent changes of tissue dielectric properties at 915 MHz, we comparatively assess two temperature dependent approaches of modeling of dielectric properties: model A- piecewise linear temperature dependencies based on existing, but limited, experimental data, and model B- similar to model A, but augmented with linear decrease in electrical conductivity above 95 °C, as guided by our experimental measurements...
May 23, 2017: Medical Physics
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