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https://www.readbyqxmd.com/read/28092862/protective-effects-of-total-flavonoids-of-astragalus-against-adjuvant-induced-arthritis-in-rats-by-regulating-opg-rankl-nf-%C3%AE%C2%BAb-pathway
#1
Xin-Yu Liu, Lu Xu, Ying Wang, Jin-Xia Li, Yu Zhang, Chong Zhang, Sha-Sha Wang, Xue-Mei Zhang
BACKGROUND: Astragalus membranaceus Bunge is one of the oldest and most frequently used crude herbs in traditional Chinese medicine. The total flavonoids of Astragalus (TFA) are the main active components isolated from Astragalus membranaceus Bunge. Our recent study has shown its potential immunomodulatory and anti-inflammatory effects in vivo and in vitro. However, its anti-arthritic effects and mechanisms of action involved have not been elucidated. The aim of this study was to evaluate the protective effects and possible mechanisms of TFA on Freund's complete adjuvant (FCA)-induced arthritis in rats...
January 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28090416/post-traumatic-arthritis-of-the-tarsometatarsal-joint-complex-a-case-report
#2
Chirag Kapoor, Amit Patel, Maulik Jhaveri, Paresh Golwala
Tarsometatarsal (TMT) arthritis is characterized by instability and pain in the foot. The commonest cause is post-traumatic arthritis. A Lisfranc injury involves the articulation between the medial cuneiform and the base of the second metatarsal, which is considered a keystone to midfoot integrity. Neglected or undertreated injury to the Lisfranc joint complex leads to secondary arthritis and significant disability. We present a case of a young male patient with a two-year-old neglected Lisfranc joint injury and secondary osteoarthritis of the first, second, and fourth TMT joints, which we treated surgically with arthrodesis using screws, with a good functional outcome on final follow-up...
December 9, 2016: Curēus
https://www.readbyqxmd.com/read/28089127/mini-invasive-treatment-for-brachymetatarsia-of-the-fourth-ray-in-females-percutaneous-osteotomy-with-mini-burr-and-external-fixation-a-case-series
#3
Federico Fusini, Francesco Langella, Ottorino Catani, Fabrizio Sergio, Fabio Zanchini
Brachymetatarsia is a rare disease defined by metatarsal shortening and characterized by aesthetic dissatisfaction with or without pain. The aim of our study was to evaluate the outcomes of fourth ray brachymetatarsia treated with percutaneous osteotomy using a mini-burr and gradual lengthening with external fixation. A total of 7 females were recruited for the study; 6 (85.71%) of whom had a bilateral deformity, for a total of 13 feet affected by fourth ray brachymetatarsia. Percutaneous diaphysis osteotomy with a mini-burr followed by metatarsal elongation was performed...
January 6, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28073655/fusion-of-the-first-metatarsophalangeal-joint-and-second-to-fifth-metatarsal-head-resection-for-rheumatoid-forefoot-deformity
#4
Pierfranco Triolo, Federica Rosso, Roberto Rossi, Raul Cerlon, Umberto Cottino, Davide Edoardo Bonasia
The goals of the present study were to evaluate the mid-term results of first metatarsophalangeal joint fusion combined with second to fifth metatarsal head resection in rheumatoid forefoot deformity and identify the prognostic factors. The inclusion criteria were 2010 American College of Rheumatology and/or European League Against Rheumatism criteria for rheumatoid arthritis; symptomatic forefoot deformity; first metatarsophalangeal joint fusion and second to fifth metatarsal head resection; and a minimum of 4 years of follow-up data available...
January 7, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28073653/rare-lateral-dislocation-of-the-first-metatarsophalangeal-joint-a-case-report-and-review-of-the-literature
#5
Amir Reza Vosoughi, Pascal F Rippstein
Traumatic lateral dislocations of the first metatarsophalangeal (MTP) joint are very rare. A 44-year-old male was referred after a motorcycle to car accident because of an exposed head of the left first metatarsal through a laceration on the medial aspect of the first MTP joint. Radiographs showed a lateral dislocation of the first MTP joint, with concomitant fractures of the neck of the second metatarsal and the base of the third and fourth metatarsal bones. The dislocation was reduced in the emergency department with the patient under conscious sedation after thorough irrigation...
January 7, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28072741/daughter-and-mother-diagnosed-with-hereditary-multiple-exostoses-a-case-report-and-a-review-of-the-literature
#6
Cristina Oana Mărginean, Lorena Elena Meliţ, Maria Oana Mărginean
INTRODUCTION: Hereditary multiple exostoses (HME) or osteochondromatosis is a rare autosomal dominant disease characterized by multiple osteochondromas and skeletal deformities. PATIENT CONCERNS & DIAGNOSES: We present the case of a 5 years and 9 month-old patient who presented with inferior limb pain for approximately 6 months, associating also deformity of the right index finger for a month. Hand X-ray revealed a radiologic abnormality of the right radius, therefore the child was referred to our clinic for further investigations...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069140/the-comparison-of-radiography-and-point-of-care-ultrasonography-in-the-diagnosis-and-management-of-metatarsal-fractures
#7
Nalan Kozaci, Mehmet Oguzhan Ay, Mustafa Avci, Inan Beydilli, Sadullah Turhan, Eda Donertas, Ertan Ararat
OBJECTIVE: It was aimed to compare the efficacy of point-of-care ultrasonography (POCUS) with radiography in the diagnosis and management of metatarsal fracture (MTF). METHODS: Patients aged 5-55 years admitted to emergency room due to low-energy, simple extremity trauma and had a suspected MTF, were included in this prospective study. Patients were evaluated by two different emergency physicians in the emergency room. The first physician performed POCUS examination...
December 23, 2016: Injury
https://www.readbyqxmd.com/read/28068797/percutaneous-hallux-valgus-surgery-without-distal-metatarsal-articular-angle-correction
#8
Eusebio Crespo Romero, Alvaro Arcas Ordoño, Raquel Peñuela Candel, Silvia Gómez Gómez, Angel Arias Arias, Jaime Gálvez González, Ricardo Crespo Romero
BACKGROUND: Many factors are considered predictors of recurrence after hallux valgus (HV) surgery, including preoperative distal metatarsal articular angle (DMAA). The restoration of the bone and joint alignment would be more important than realigning the cartilaginous surface of the metatarsal head. Therefore, is DMAA correction essential for a good clinical and radiological results after HV surgery? This study aims to illustrate the results of percutaneous forefoot surgery (PFS) for correction of HV deformity without DMAA correction...
January 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28065645/mandibular-reconstruction-with-vascularised-bone-flaps-a-systematic-review-over-25-years
#9
REVIEW
J S Brown, D Lowe, A Kanatas, A Schache
To explore the techniques for mandibular reconstruction with composite free flaps and their outcomes, we systematically reviewed reports published between 1990 and 2015. A total of 9499 mandibular defects were reconstructed with 6178 fibular, 1380 iliac crest, 1127 composite radial, 709 scapular, 63 serratus anterior and rib, 32 metatarsal, and 10 lateral arm flaps including humerus. The failure rate was higher for the iliac crest (6.2%, 66/1059) than for fibular, radial, and scapular flaps combined (3.4%, 202/6018) (p<0...
January 5, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28060328/culture-of-murine-embryonic-metatarsals-a-physiological-model-of-endochondral-ossification
#10
Dean A Houston, Katherine A Staines, Vicky E MacRae, Colin Farquharson
The fundamental process of endochondral ossification is under tight regulation in the healthy individual so as to prevent disturbed development and/or longitudinal bone growth. As such, it is imperative that we further our understanding of the underpinning molecular mechanisms involved in such disorders so as to provide advances towards human and animal patient benefit. The mouse metatarsal organ explant culture is a highly physiological ex vivo model for studying endochondral ossification and bone growth as the growth rate of the bones in culture mimic that observed in vivo...
December 3, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28058661/an-old-mismanaged-lisfranc-injury-treated-by-gradual-deformity-correction-followed-by-the-second-stage-internal-fixation
#11
Mehraj D Tantray, Khurshid Kangoo, Asif Nazir, Muzamil Baba, Raja Rameez, Syed Tabish, Syed Shahnawaz
The Lisfranc fracture-dislocation of the foot is uncommon and diagnosis is often missed. The Lisfranc joint involves the articulation between medial cuneiform and base of the second metatarsal and is considered a keystone to structural integrity to the midfoot. The articulation has a stabilization effect on longitudinal and transverse arches of the foot. A neglected or untreated injury to the Lisfranc joint can lead to secondary arthritis and significant morbidity and disability. We present a case of a neglected Lisfranc fracture-dislocation in a 28-year-old female patient who presented 3 months after injury...
January 5, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/28043054/dynamic-plantar-pressure-distribution-strength-capacity-and-postural-control-after-lisfranc-fracture-dislocation
#12
Alexander T Mehlhorn, Markus Walther, Tayfun Yilmaz, Lennart Gunst, Anja Hirschmüller, Norbert P Südkamp, Hagen Schmal
Substantial progress has been made in the operative treatment of Lisfranc fractures, however, the prognosis remains poor. We hypothesized that Lisfranc injuries change the postural control and muscle strength of the lower limb. Both are suggested to correlate with the clinical outcome and quality of life. 17 consecutive patients suffering from a Lisfranc fracture dislocation were registered, underwent open reduction and internal fixation and were followed-up for 50.5±25.7months (Mean±SDM). Biomechanical analysis of muscle strength capacities, postural control and plantar pressure distribution was assessed >6 month postoperatively...
December 19, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28035908/plantar-pressures-increase-with-raising-body-weight-a-standardised-approach-with-paired-sample-using-neutral-shoes
#13
T Hotfiel, H D Carl, F Wendler, A Jendrissek, R Heiß, B Swoboda
BACKGROUND: Plantar pressure leads to stress on plantar tissue and can be seen as risk factor for metatarsal stress fractures or plantar ulcers and is associated with prolonged and complicated recurrence of existing tissue damages. A clear demarcation of a systematic raise of body load regarding its effect on plantar pressure has not been described. OBJECTIVE: Assessing plantar pressure in different conditions of body weight, comparing data to initial body weight...
December 23, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28035313/rare-case-of-tibial-hemimelia-preaxial-polydactyly-and-club-foot
#14
Guinevere Granite, John E Herzenberg, Ronald Wade
A seven-month old female presented with left tibial hemimelia (or congenital tibial aplasia; Weber type VIIb, Jones et al type 1a), seven-toed preaxial polydactyly, and severe club foot (congenital talipes equinovarus). Definitive amputation surgery disarticulated the lower limb at the knee. This case report describes the anatomical findings of a systematic post-amputation examination of the lower limb's superficial dissection, X-rays, and computed tomography (CT) scans. From the X-rays and CT scans, we found curved and overlapping preaxial supernumerary toes, hypoplastic first metatarsal, lack of middle and distal phalanges in one supernumerary toe, three tarsal bones, hypoplastic middle phalanx and no distal phalanx for fourth toe, and no middle or distal phalanges for fifth toe...
December 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28032852/-osteomyelitis-due-to-shewanella-putrefaciens-case-report-and-literature-review
#15
Katia Guinetti-Ortiz, Alejandra Bocanegra-Jesús, Andrea Gómez de la Torre-Del Carpio
Shewanella putrefaciens is a Gram-negative bacillus and marine pathogen that rarely causes disease in humans. We report a case of osteomyelitis by this organism in a 48-year-old male patient, who presented with pain and erythema of the right foot that was initially diagnosed as cellulitis and did not revert despite treatment. He was transferred to Lima where osteomyelitis was diagnosed and started on empirical treatment with partial regression. A biopsy and culture of the compromised area found S. putrefaciens...
November 29, 2016: Medwave
https://www.readbyqxmd.com/read/28032031/fifth-metatarsal-fractures-and-current-treatment
#16
REVIEW
Julia Bowes, Richard Buckley
Metatarsal fractures are one of the most common injuries of the foot. There has been conflicting literature on management of fifth metatarsal fractures due to inconsistency with respect to classification of these fractures. This article provides a thorough review of fifth metatarsal fractures with examination of relevant literature to describe the management of fifth metatarsal fractures especially the proximal fracture. A description of nonoperative and operative management for fifth metatarsal fractures according to anatomical region is provided...
December 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28031504/comparison-of-early-outcome-of-weil-osteotomy-and-distal-metatarsal-mini-invasive-osteotomy-for-lesser-toe-metatarsalgia
#17
Nicholas Eng Meng Yeo, Bryan Loh, Jerry YongQiang Chen, Andy Khye Soon Yew, Sean Yc Ng
PURPOSE: To compare the 6-month outcome of Weil osteotomy with distal metatarsal mini-invasive osteotomy (DMMO) in 33 patients with lesser toe metatarsalgia. METHODS: Records of 33 patients who underwent Weil osteotomy (n=20, 41 toes) or DMMO (n=13, 22 toes) for lesser toe metatarsalgia by a single surgeon were reviewed. 25 of them had a concurrent procedure on the 1st toe. Outcome at 6 months was assessed using the visual analogue score (VAS) for pain, American Orthopaedic Foot and Ankle Society (AOFAS) lesser toe metatarsophalangeal-interphalangeal (MTP-IP) score, and the RAND-36 score...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28018488/relationship-between-patient-reported-outcome-measures-prom-and-three-measures-of-foot-ankle-alignment-in-patients-with-metatarsal-head-pain-a-cross-sectional-study
#18
Manuel González-Sánchez, Esther Velasco-Ramos, Maria Ruiz Muñoz, Antonio I Cuesta-Vargas
BACKGROUND: The aim of the present study is to establish the relationship between foot-ankle patient-reported outcome measures (PROM) and three measures of foot-ankle alignment (MoFAA) in patients with metatarsal head pain. METHODS: A cross-sectional study where 206 patients completed three PROMs and a clinician recorded three MoFAA bilaterally (three times each). A reliability analysis of the MoFAA, a correlation analysis (between MoFAA and PROM) and regression analysis (dependent variable: PROM; independent variables: MoFAA) were performed...
2016: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28008240/a-comparison-between-metatarsal-head-resurfacing-hemiarthroplasty-and-total-metatarsophalangeal-joint-arthroplasty-as-surgical-treatments-for-hallux-rigidus-a-retrospective-study-with-short-to-midterm-follow-up
#19
Musa Ugur Mermerkaya, Houman Adli
PURPOSE: We evaluated the short- to midterm outcomes of metatarsal head-resurfacing hemiarthroplasty and total metatarsophalangeal joint arthroplasty (total joint replacement [TJR]) as surgical treatments for advanced-stage hallux rigidus (HR). PATIENTS AND METHODS: From 2012 to 2014, all data from patients who underwent surgery for the treatment of grades 2-3 HR were retrospectively reviewed, and 45 patients were included in this study. Of these patients, 26 underwent metatarsal head-resurfacing hemiarthroplasty (Group I) and 19 underwent TJR (Group II)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28005495/growth-plate-lesions-of-fattening-bulls
#20
M Levi, K E Dittmer, A Gentile, A Beltrame, M Bolcato, M Morgante, E Fiore, C Benazzi
Lameness related to growth plate lesions is an important problem in the beef industry. This article describes the macroscopic and microscopic lesions in the distal metatarsal physis of bulls from an association of farmers in northeastern Italy. The metatarsal bones of 62 bulls (12 with severe lameness and 50 without lameness), average age 16.44 ± 1.72 months, were examined at the abattoir. The animals came from the same geographic area and shared intensive husbandry practices and a diet based on maize starch...
January 1, 2016: Veterinary Pathology
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