Iliana Bersani, Giuseppe Lapergola, Roberta Patacchiola, Ebe D'Adamo, Liborio Stuppia, Vincenzo de Laurenzi, Verena Damiani, Ivana Cataldo, Katia Clemente, Adele Primavera, Rita Salomone, Elisabetta Barbante, Francesca Campi, Immacolata Savarese, Sara Ronci, Andrea Dotta, Annabella Braguglia, Daniela Longo, Danilo A W Gavilanes, Francesca Gazzolo, Laura Serpero, Maria Chiara Strozzi, Antonio Maconi, Maurizio Cassinari, Roberta Libener, Diego Gazzolo
OBJECTIVES: Seizures (SZ) are one of the main complications occurring in infants undergoing therapeutic hypothermia (TH) due to perinatal asphyxia (PA) and hypoxic ischemic encephalopathy (HIE). Phenobarbital (PB) is the first-line therapeutic strategy, although data on its potential side-effects need elucidation. We investigated whether: i) PB administration in PA-HIE TH-treated infants affects S100B urine levels, and ii) S100B could be a reliable early predictor of SZ. METHODS: We performed a prospective case-control study in 88 PA-HIE TH infants, complicated (n=44) or not (n=44) by SZ requiring PB treatment...
January 30, 2024: Clinical Chemistry and Laboratory Medicine: CCLM