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https://www.readbyqxmd.com/read/28088747/decreased-s100b-serum-levels-after-treatment-in-bipolar-patients-in-a-manic-phase
#1
Meng-Chang Tsai, Tiao-Lai Huang
BACKGROUND: Previous studies have suggested that patients with bipolar disorder might have brain damage. The aim of this study was to investigate the serum levels of brain injury biomarkers and S100A10 in bipolar patients in a manic phase, and evaluate the changes in S100B, neuron specific enolase (NSE), heat shock protein 70 (HSP70) and S100A10 after treatment. METHOD: We consecutively enrolled 17 bipolar inpatients in a manic phase and 30 healthy subjects. Serum brain injury biomarkers and S100A10 were measured with assay kits...
January 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28063977/enteric-glial-reactivity-to-systemic-lps-administration-changes-in-gfap-and-s100b-protein
#2
Raphaela da Cunha Franceschi, Patrícia Nardin, Clivia Valle Machado, Lucas Silva Tortorelli, Malcon Andrei Martinez-Pereira, Carolline Zanotto, Carlos Alberto Gonçalves, Denise Maria Zancan
Lipopolysaccharide (LPS) is used to induce inflammation and promotes nervous system activation. Different regions of the brain present heterogeneous glial responses; thus, in order to verify whether systemic LPS-induced inflammation affects the enteric glia differently across the intestinal segments, we evaluated the expressions of two glial activity markers, GFAP and S100B protein, in different intestine segments, at 1h, 24h and 7days after acute systemic LPS administration (0.25 or 2.5mg kg-1) in rats. Histological inflammatory analysis indicated that the cecum was most affected when compared to the duodenum and proximal colon at the highest doses of LPS...
January 4, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28033253/postoperative-cognitive-changes-after-total-knee-arthroplasty-under-regional-anesthesia
#3
Young-Tae Jeon, Byung-Gun Kim, Young Ho Park, Hye-Min Sohn, Jungeun Kim, Seung Chan Kim, Seong Soo An, SangYun Kim
BACKGROUND: The type of postoperative cognitive decline after surgery under spinal anesthesia is unknown. We investigated the type of postoperative cognitive decline after total knee arthroplasty (TKA). Neuropsychological testing was conducted and the changes in cerebrospinal fluid (CSF) biomarkers after surgery were evaluated. METHODS: Fifteen patients who required bilateral TKA at a 1-week interval under spinal anesthesia were included. Neuropsychological tests were performed twice, once the day before the first operation and just before the second operation (usually 1 week after the first test) to determine cognitive decline...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28031000/modeling-the-kinetics-of-serum-glial-fibrillary-acidic-protein-ubiquitin-carboxyl-terminal-hydrolase-l1-and-s100b-concentrations-in-patients-with-traumatic-brain-injury
#4
Robert D Welch, Morgan Ellis, Lawrence M Lewis, Syed Imran Ayaz, Valerie H Mika, Scott R Millis, Linda Papa
Glial fibrillary acidic protein (GFAP), Ubiquitin Carboxyl-Terminal Hydrolase-L1 (UCH-L1), and S100B have been shown to be predictive of patients with brain injury. Kinetics of these biomarkers in injured humans have not been extensively examined. This prospective multi-center study included patients with mild to moderate traumatic brain injury. Blood samples obtained at enrollment and every 6 hours up to 24 hours post-injury were assayed for GFAP, UCH-L1, and S100B. Random effects models examined changes in the biomarkers' level over time...
December 28, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28027282/role-of-rifampin-in-reducing-inflammation-and-neuronal-damage-in-childhood-bacterial-meningitis-a-pilot-randomized-controlled-trial
#5
Lipi Uppal, Sunit Singhi, Pratibha Singhi, Ritu Aggarwal
BACKGROUND: Treatment of acute bacterial meningitis in children with bactericidal antibiotics causes cell wall lysis and a surge in inflammatory cascade, which in turn contributes to neuronal damage and morbidity. Pretreament with a non-bacteriolytic antibiotic, such as rifampin, has been shown to attenuate the inflammatory response in experimental models of bacterial meningitis. In a pilot study in children with bacterial meningitis we have studied markers of inflammatory response and neuronal damage in two groups of children with bacterial meningitis, one group received rifampin pretreatment with ceftriaxone, other group received ceftriaxone alone...
December 23, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27995575/cerebrospinal-fluid-biomarkers-and-hiv-associated-neurocognitive-disorders-in-hiv-infected-individuals-in-rakai-uganda
#6
Mahsa Abassi, Bozena M Morawski, Gertrude Nakigozi, Noeline Nakasujja, Xiangrong Kong, David B Meya, Kevin Robertson, Ronald Gray, Maria J Wawer, Ned Sacktor, David R Boulware
In the USA, increased cerebrospinal fluid (CSF) inflammatory cytokines have been observed in antiretroviral therapy (ART)-naive, HIV-seropositive individuals with HIV-associated neurocognitive disorder (HAND). We characterized the relationship between HAND and CSF biomarker expression in ART-naive, HIV-seropositive individuals in Rakai, Uganda. We analyzed CSF of 78 HIV-seropositive, ART-naive Ugandan adults for 17 cytokines and 20 neurodegenerative biomarkers via Luminex multiplex assay. These adults underwent neurocognitive assessment to determine their degree of HAND...
December 19, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27995066/functional-resting-state-fmri-connectivity-correlates-with-serum-levels-of-the-s100b-protein-in-the-acute-phase-of-traumatic-brain-injury
#7
William Hedley Thompson, Eric Peter Thelin, Anders Lilja, Bo-Michael Bellander, Peter Fransson
The S100B protein is an intra-cellular calcium-binding protein that mainly resides in astrocytes in the central nervous system. The serum level of S100B is used as biomarker for the severity of brain damage in traumatic brain injury (TBI) patients. In this study we investigated the relationship between intrinsic resting-state brain connectivity, measured 1-22 days (mean 8 days) after trauma, and serum levels of S100B in a patient cohort with mild-to-severe TBI in need of neuro-intensive care in the acute phase...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27994924/correlation-between-amitriptyline-induced-cardiotoxic-effects-and-cardiac-s100b-protein-in-isolated-rat-hearts
#8
Nil Hocaoğlu, Nergis Murat, Serap Cilaker Mıcılı, Burç Aydın, Bekir Uğur Ergür, Şule Kalkan
BACKGROUND: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. AIMS: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model. STUDY DESIGN: Animal experimentation, isolated heart model. METHODS: After a stabilization period, isolated hearts were randomized to two groups (n=5 and n=7)...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27989465/neuroprotective-effect-of-sevoflurane-in-general-anaesthesia
#9
Victoria Ramos Ramos, Pablo Mesa Suárez, José Diego Santotoribio, María Ángela González García, Antonio Muñoz Hoyos
INTRODUCTION AND OBJECTIVE: The aim of this study was to evaluate the brain damage caused by inhaled sevoflurane, by determining the concentration of serum S100B protein before and after the exposure to this drug as the only anaesthetic agent. PATIENTS AND METHOD: Paediatric patients undergoing general anaesthesia for the conduct of a nuclear magnetic resonance were included in the study. A venous blood sample was taken from each patient before (basal sample) and after (post-exposure sample) administering the general anaesthesia...
December 15, 2016: Medicina Clínica
https://www.readbyqxmd.com/read/27957604/a-review-of-the-clinical-utility-of-serum-s100b-protein-levels-in-the-assessment-of-traumatic-brain-injury
#10
REVIEW
Eric Peter Thelin, David W Nelson, Bo-Michael Bellander
BACKGROUND: In order to improve injury assessment of brain injuries, protein markers of pathophysiological processes and tissue fate have been introduced in the clinic. The most studied protein "biomarker" of cerebral damage in traumatic brain injury (TBI) is the protein S100B. The aim of this narrative review is to thoroughly analyze the properties and capabilities of this biomarker with focus on clinical utility in the assessment of patients suffering from TBI. RESULTS: S100B has successfully been implemented in the clinic regionally (1) to screen mild TBI patients evaluating the need to perform a head computerized tomography, (2) to predict outcome in moderate-to-severe TBI patients, (3) to detect secondary injury development in brain-injured patients and (4) to evaluate treatment efficacy...
December 12, 2016: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27956799/transient-receptor-potential-vanilloid-1-immunoreactive-signals-in-murine-enteric-glial-cells
#11
Masahiro Yamamoto, Mitsue Nishiyama, Seiichi Iizuka, Shigeaki Suzuki, Norihiro Suzuki, Sadakazu Aiso, Jin Nakahara
AIM: To investigate the possible involvement of transient receptor potential vanilloid 1 (TRPV1) in maturation of enteric glial cells (EGCs). METHODS: Immunohistochemical and immunocytochemical techniques were used to analyze EGC markers in myenteric plexus (MP) as well as cultured MP cells and EGCs using TRPV1 knockout (KO) mice. RESULTS: We detected TRPV1-immunoreactive signals in EGC in the MP of wild-type (WT) but not KO mice. Expression of glial fibrillary acidic protein (GFAP) immunoreactive signals was lower at postnatal day (PD) 6 in KO mice, though the difference was not clear at PD 13 and PD 21...
November 28, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27943583/human-dental-pulp-stem-cells-expressing-stro-1-c-kit-and-cd34-markers-in-peripheral-nerve-regeneration
#12
Gianluca Carnevale, Alessandra Pisciotta, Massimo Riccio, Laura Bertoni, Sara De Biasi, Lara Gibellini, Alessio Zordani, Gian Maria Cavallini, Giovanni Battista La Sala, Giacomo Bruzzesi, Adriano Ferrari, Andrea Cossarizza, Anto de Pol
Peripheral nerve injuries are a commonly encountered clinical problem and often result in long-term functional defects. The application of stem cells able to differentiate in Schwann cells-like cells in vitro and in vivo, could represent an attractive therapeutic approach for the treatment of nerve injuries. Further, stem cells sources sharing the same embryological origin of Schwann cells might be considered a suitable tool. The aim of this study was to demonstrate the ability of a neuroectodermal subpopulation of human STRO-1+/c-Kit+/CD34+ DPSCs, expressing P75(NTR) , Nestin and SOX-10, to differentiate into Schwann cells-like cells in vitro and to promote axonal regeneration in vivo, which led to functional recovery as measured by sustained gait improvement, in animal rat model of peripheral nerve injury...
December 11, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27931233/venlafaxine-ameliorates-the-depression-like-behaviors-and-hippocampal-s100b-expression-in-a-rat-depression-model
#13
Chang-Hong Wang, Jing-Yang Gu, Xiao-Li Zhang, Jiao Dong, Jun Yang, Ying-Li Zhang, Qiu-Fen Ning, Xiao-Wen Shan, Yan Li
BACKGROUND: Accumulating evidence has indicated that S100B may be involved in the pathophysiology of depression. No published study has examined the effect of the antidepressant drug venlafaxine on S100B in animal models of depression. This study investigated S100B expression in the hippocampus and assessed the effect of venlafaxine on S100B mRNA level and protein expression in rats exposed to chronic unpredictable mild stress (CUMS). METHODS: Forty Sprague-Dawley rats were randomly divided into four groups as control, 0, 5 and 10 mg venlafaxine groups...
December 8, 2016: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/27929120/neurofilaments-in-blood-and-csf-for-diagnosis-and-prediction-of-onset-in-creutzfeldt-jakob-disease
#14
Petra Steinacker, Kaj Blennow, Steffen Halbgebauer, Song Shi, Viktoria Ruf, Patrick Oeckl, Armin Giese, Jens Kuhle, Dana Slivarichova, Henrik Zetterberg, Markus Otto
While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated NF heavy chain (pNF-H), tau, S100B, 14-3-3) and prion conversion assay (real-time quaking induced conversion (RT-QuIC)) for sporadic and genetic CJD. Importantly, a Gerstmann-Sträussler-Scheinker mutation carrier in the asymptomatic phase and at disease onset was included as well...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27928847/zinc-protection-in-fetal-rats-for-maternal-mercury-exposure-induced-growth-retardation-is-probably-associated-with-s100b-expression
#15
Zhanping Weng, Zonghua Liu, Shuping Zhang, Hong Tao, Xianghong Ji
AIM: The study was conducted to investigate the effects of maternal mercury exposure on fetal rat development and zinc protection in mercury-exposed rats. METHODS: Pregnant rats were subjected to zinc sulfate pre-feeding, mercury exposure and zinc sulfate co-feeding. The control rats were administered distilled water. On day 19, the placental weight, overall weight, size and tail length of fetal rats, mercury content and S100B level in the placenta were determined using Western blot analysis...
December 8, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27925190/s100a1-and-s100b-calcium-sensors-at-the-cross-roads-of-multiple-chondrogenic-pathways
#16
REVIEW
José Diaz-Romero, Dobrila Nesic
The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 + -activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human articular chondrocytes. Both proteins are homogeneously expressed in all cartilage zones, their expression decreases during chondrocyte dedifferentiation, and can be induced under conditions promoting redifferentiation...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27906424/s100b-in-serum-and-saliva-a-valid-invasive-or-non-invasive-biomarker-in-obstructive-sleep-apnea
#17
M Traxdorf, O Wendler, K Tziridis, J Bauer, C Scherl
OBJECTIVE:   The aim of this prospective study was to determine whether serum or saliva S100B could be established as an invasive or non-invasive biomarker of cerebrovascular stress due to chronic intermittent hypoxia in obstructive sleep apnea (OSA). PATIENTS AND METHODS: S100B levels in serum and saliva were measured by an enzyme-linked immunosorbent assay (ELISA) in 40 patients with polysomnographically confirmed OSA (n=34) or ronchopathy (n=6) and 20 control subjects (n=20)...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27903281/improving-the-clinical-management-of-traumatic-brain-injury-through-the-pharmacokinetic-modeling-of-peripheral-blood-biomarkers
#18
Aaron Dadas, Jolewis Washington, Nicola Marchi, Damir Janigro
BACKGROUND: Blood biomarkers of neurovascular damage are used clinically to diagnose the presence severity or absence of neurological diseases, but data interpretation is confounded by a limited understanding of their dependence on variables other than the disease condition itself. These include half-life in blood, molecular weight, and marker-specific biophysical properties, as well as the effects of glomerular filtration, age, gender, and ethnicity. To study these factors, and to provide a method for markers' analyses, we developed a kinetic model that allows the integrated interpretation of these properties...
November 30, 2016: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/27882497/soluble-tlr2-and-4-concentrations-in-cerebrospinal-fluid-in-hiv-siv-related-neuropathological-conditions
#19
Khutso M Mothapo, J Ten Oever, P Koopmans, F F Stelma, S Burm, J Bajramovic, M M Verbeek, M G Olde Rikkert, M G Netea, G Koopman, A J van der Ven
HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This paper aimed to study the role of soluble TLR2 (sTLR2), sTLR4, and other inflammatory markers in cerebrospinal fluid (CSF) in HIV/Simian immunodeficiency virus (SIV)-related neurological sequelae. We determined sTLR2 and sTLR4 levels in CSF and serum/plasma of SIV-infected rhesus macaques with and without neurological sequelae, as well as in HIV-infected patients with and without cognitive impairments and Alzheimer's disease (AD) patients and matched controls...
November 23, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27870504/chronic-licl-pretreatment-suppresses-thrombin-stimulated-intracellular-calcium-mobilization-through-trpc3-in-astroglioma-cells
#20
Takuji Uemura, Marty Green, Jerry J Warsh
OBJECTIVES: Transient receptor potential canonical type 3 (TRPC3) channels are activated in B lymphoblast cell lines from patients with bipolar disorder (BD), and its expression is reduced by chronic lithium treatment, implicating TRPC3 in the intracellular calcium (Ca(2+) ) dyshomeostasis of BD. Thrombin, via a protease-activated receptor, moderates Ca(2+) signaling and TRPC3 in astrocytes, and also cell proliferation. We examined whether lithium pretreatment attenuates thrombin-stimulated TRPC3 expression and function in astrocytes, and levels of the calcium-binding peptide, S100B, which is expressed mainly in these cells...
November 2016: Bipolar Disorders
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