Kihyun Kim, Mark H Lee, Jingook Kim, Kyung Soo Lee, Sung Min Kim, Man Pyo Jung, Joungho Han, Ki Woong Sung, Won Seog Kim, Chul Won Jung, Sung Soo Yoon, Young-Hyuck Im, Won Ki Kang, Keunchil Park, Chan Hyung Park
Invasive pulmonary aspergillosis is a serious infectious complication in immunocompromised patients. Recent reports indicate its favorable clinical outcomes by early diagnosis with chest computed tomography scan. We retrospectively analyzed our experiences with histopathological evaluation by open lung biopsy in 31 patients (32 cases) with hematologic malignancies, suspected of having invasive pulmonary aspergillosis clinically and radiologically. Although the initial computed tomography findings of all cases were highly indicative of invasive pulmonary aspergillosis by demonstrating nodules or masses with a halo sign (16 cases), segmental area of consolidation with ground-glass attenuation (7 cases), both nodules or masses with a halo sign and segmental area of consolidation with ground-glass attenuation (7 cases) and poorly defined centrilobular nodules (2 cases), we could histopathologically confirm invasive fungal infections only in 17 cases (53...
October 2002: American Journal of Hematology