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Tal Milman, Raed A Joundi, Naif M Alotaibi, Gustavo Saposnik
BACKGROUND: Clinical Inertia is defined as "failure of health care providers to initiate or intensify therapy according to current guidelines". This phenomenon is gaining increasing attention as a major cause of clinicians' failure to adequately manage hypertension, thus leading to an increased incidence of cardiovascular events. We performed a systematic review and meta-analysis of randomized controlled trials to determine whether interventions aimed at reducing clinical inertia in the pharmacological treatment of hypertension improve blood pressure (BP) control...
June 2018: Medicine (Baltimore)
Heeju Ryu, Hoyong Lim, Garam Choi, Young-Jun Park, Minkyoung Cho, Hyeongjin Na, Chul Won Ahn, Young Chul Kim, Wan-Uk Kim, Sang-Hak Lee, Yeonseok Chung
In the version of this article initially published, the third label along the horizontal axis of Fig. 4b (Il13a) and the middle label above each plot in Fig. 6k (Stat-/- ) were incorrect, and the hash marks along the horizontal axis for Fig. 6i were spaced incorrectly. Also, the statistical results in the citation for Supplementary Fig. 5a (*P < 0.05, **P < 0.01 and ***P < 0.001 (unpaired Student's t-test)) in the fifth subsection of Results were incorrect. The correct label for Fig. 4b is Il23a and for Fig...
June 19, 2018: Nature Immunology
Leen Vereenooghe, Samantha Flynn, Richard P Hastings, Dawn Adams, Umesh Chauhan, Sally-Ann Cooper, Nick Gore, Chris Hatton, Kerry Hood, Andrew Jahoda, Peter E Langdon, Rachel McNamara, Chris Oliver, Ashok Roy, Vasiliki Totsika, Jane Waite
OBJECTIVE: Mental health problems are more prevalent in people with than without intellectual disabilities, yet treatment options have received little attention. The aim of this study was to identify and evaluate the effectiveness of pharmacological and psychological interventions in the treatment of mental health problems in children and adults with severe and profound intellectual disabilities, given their difficulties in accessing standard mental health interventions, particularly talking therapies, and difficulties reporting drug side effects...
June 19, 2018: BMJ Open
Katerina Pavenski, Simon Stanworth, Mark Fung, Erica M Wood, Joanne Pink, Michael F Murphy, Heather Hume, Susan Nahirniak, Kathryn E Webert, Susano Tanael, Denise Landry, Nadine Shehata
Many transfusion guidelines are available, but little appraisal of their quality has been undertaken. The quality of guidelines may potentially influence adoption. Our aim was to determine the quality of evidence-based transfusion guidelines (EBG) for red cells and plasma, using the Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument, and assess duplication and consistency of recommendations. MEDLINE and EMBASE were systematically searched for EBG from 2005 to June 3, 2016. Citations were reviewed for inclusion in duplicate...
June 1, 2018: Transfusion Medicine Reviews
I Made Ady Wirawan, Robin F Griffiths, Peter D Larsen
BACKGROUND: This study aims to examine which marker or testing protocols have been suggested for cardiovascular disease (CVD) risk assessment in asymptomatic populations, at which CVD risk level, and how this can be implemented for CVD risk assessment in pilot populations. METHODS: A systematic search was performed using Systematic Reviews Subset on PubMed; the OvidSP interface, including all EBM reviews and EMBASE databases; and the G-I-N International Guideline Library...
July 1, 2018: Aerospace Medicine and Human Performance
Heather Carter-Templeton, Rachel M Frazier, Lin Wu, Tami H Wyatt
PURPOSE: The purpose of this study was to describe the current evidence found in the nursing literature about robotics used to assist or augment nursing care. METHODS: A bibliometric analysis of published research focused on robotics in nursing care was conducted to analyze the trends of publications. A search of the Cumulative Index to Nursing and Allied Health Literature database was conducted. This analysis was used to determine the types and extent of robotic research presented in nursing and allied health literature, journals that publish robotic research, and the origins of the study...
June 19, 2018: Journal of Nursing Scholarship
Lara A Kahale, Maram B Hakoum, Ibrahim G Tsolakian, Charbel F Matar, Irene Terrenato, Francesca Sperati, Maddalena Barba, Victor Ed Yosuico, Holger Schünemann, Elie A Akl
BACKGROUND: Cancer increases the risk of thromboembolic events, especially in people receiving anticoagulation treatments. OBJECTIVES: To compare the efficacy and safety of low molecular weight heparins (LMWHs), direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) for the long-term treatment of venous thromboembolism (VTE) in people with cancer. SEARCH METHODS: We conducted a literature search including a major electronic search of the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE (Ovid), and Embase (Ovid); handsearching conference proceedings; checking references of included studies; use of the 'related citation' feature in PubMed and a search for ongoing studies in trial registries...
June 18, 2018: Cochrane Database of Systematic Reviews
Carolyn S Dewa, Desmond Loong, Austin Trujillo, Sarah Bonato
PURPOSE: People with mental illnesses are at a significantly greater risk of police arrest than the general population. This pattern of arrests has been associated with a phenomenon referred to as the criminalization of mental illness such that people with mental illnesses are inappropriately diverted to the criminal justice system rather than to treatment. To decrease arrests of people with mental illnesses experiencing a crisis, pre-booking diversion programs have been developed to intervene at the point of police contact...
2018: PloS One
Ann Kristin Bjørnnes, Monica Parry, Marit Leegaard, Ana Patricia Ayala, Erica Lenton, Paula Harvey, Judith McFetridge-Durdle, Michael H McGillion, Jennifer Price, Jennifer Stinson, Judy Watt-Watson
Symptom recognition and self-management is instrumental in reducing the number of deaths related to coronary artery disease (CAD) in women. The purpose of this study was to synthesize qualitative research evidence on the self-management of cardiac pain and associated symptoms in women. Seven databases were systematically searched, and the concepts of the Individual and Family Self-Management Theory were used as the framework for data extraction and analysis. Search strategies yielded 22,402 citations, from which 35 qualitative studies were included in a final meta-summary, comprising data from 769 participants, including 437 (57%) women...
June 1, 2018: Qualitative Health Research
Waleed M Sweileh
BACKGROUND: In the past few decades Arab countries had witnessed several intra-regional conflicts and civil wars that led to the creation of millions of refugees and migrants. Assessment of research activity is an indicator of national and international efforts to improve the health of those millions of war victims. Therefore, the aim of this study was to analyze published literature in international Arab migrants. METHODS: Literature in international Arab migrants published during the past three decades (1988-2017) was retrieved using Scopus database...
June 18, 2018: BMC Public Health
Naji C Salloum, Erica Lf Buchalter, Swati Chanani, Gemma Espejo, Mahjabeen S Ismail, Randy O Laine, Maysaa Nageeb, A Benjamin Srivastava, Nicholas Trapp, Ludwig Trillo, Erica Vance, Michael Wenzinger, Sarah M Hartz, Sean P David, Li-Shiun Chen
Smoking cessation treatment outcomes may be heavily influenced by genetic variations among smokers. Therefore, identifying specific variants that affect response to different pharmacotherapies is of major interest to the field. In the current study, we systematically review all studies published in or after the year 1990 which examined one or more gene-drug interactions for smoking cessation treatment. Out of 644 citations, 46 articles met the inclusion criteria for the systematic review. We summarize evidence on several genetic polymorphisms (CHRNA5-A3-B4, CYP2A6, DBH, CHRNA4, COMT, DRD2, DRD4 and CYP2B6) and their potential moderating pharamacotherarpy effects on patient cessation efficacy rates...
June 19, 2018: Pharmacogenomics
Lotte Nygaard Andersen, Maria Kohberg, Birgit Juul-Kristensen, Lene Gram Herborg, Karen Søgaard, Kirsten Kaya Roessler
Background and objective Chronic pain is a growing phenomenon worldwide. It is considered a medical problem because, besides the socio-economic issues involved, pain is often accompanied by psychosocial problems. Apart from the physical pain, living with chronic pain has many additional consequences. People living with chronic pain generally suffer from other physical and psychological consequences. The impact of chronic pain varies enormously between individuals, but the suffering is frequently pervasive and detrimental...
December 29, 2017: Scandinavian Journal of Pain
Veronika Mandlik, Lukas Prantl, Andreas G Schreyer
BACKGROUND:  Contrast extravasation events in daily radiological routine may lead to serious complications, especially during CT examinations. The resulting symptoms may vary from local pain up to skin ulcers, necrosis or even acute compartment syndrome.There are no uniformly accepted radiological guidelines or recommendations regarding detection and treatment of extravasation events and immanent complications in a timely manner. METHOD:  Systematic literature research considering the last 35 years via PubMed using search terms "contrast medium extravasation/paravasation"...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Areti Angeliki Veroniki, Jesmin Antony, Sharon E Straus, Huda M Ashoor, Yaron Finkelstein, Paul A Khan, Marco Ghassemi, Erik Blondal, John D Ivory, Brian Hutton, Kevin Gough, Brenda R Hemmelgarn, Erin Lillie, Afshin Vafaei, Andrea C Tricco
BACKGROUND: Nearly all newly infected children acquire Human Immunodeficiency virus (HIV) via mother-to-child transmission (MTCT) during pregnancy, labour or breastfeeding from untreated HIV-positive mothers. Antiretroviral therapy (ART) is the standard care for pregnant women with HIV. However, evidence of ART effectiveness and harms in infants and children of HIV-positive pregnant women exposed to ART has been largely inconclusive. The aim of our systematic review and network meta-analysis (NMA) was to evaluate the comparative safety and effectiveness of ART drugs in children exposed to maternal HIV and ART (or no ART/placebo) across different study designs...
2018: PloS One
(no author information available yet)
Lara A Boland and Vanessa R Barrs J Feline Med Surg 2017; 19: 933-947 Readers should note that the version of the article that appeared in print in September 2017 and online until June 2018 has been amended. The version now appearing online is the correct one. For information, the following amendments have been made to the original published version. The caption for Figure 6 on page 936 has been amended to 'Lithium heparin blood sample from the cat pictured in Figure 1. This was grossly lipaemic despite fasting, due to hypertriglyceridaemia, which occurs in approximately 7% of cats with HAC'...
June 1, 2018: Journal of Feline Medicine and Surgery
Amir Almasi-Hashiani, Erfan Ayubi, Kamyar Mansori, Mostafa Salehi-Vaziri, Yousef Moradi, Behzad Gholamaliei, Salman Khazaei
Aim: Present study aimed to systematically review and quantitatively synthesize published data about the prevalence of Hepatitis B Virus (HBV) infection among high risk groups in Iran. Background: Determining true burden of Hepatitis B Virus (HBV) infection among high-risk groups relies on knowledge of occurrence measures such as prevalence rate. There is no conclusive and comprehensive data regarding to prevalence of HBV infection among high risk groups in Iran...
2018: Gastroenterology and Hepatology From Bed to Bench
Fang Fang, Yu Bai, Yu Zhang, Andrew Faramand
OBJECTIVE: To determine the effect of the using oil-soluble contrast material (OSCM) vs. water-soluble contrast material (WSCM) for hysterosalpingography on pregnancy rates in infertile women. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Infertile women. INTERVENTION(S): We included randomized controlled trials comparing pregnancy outcomes in women with infertility undergoing hysterosalpingography using OSCM and WSCM...
June 13, 2018: Fertility and Sterility
Jan-Eric Olsson, Solvig Ekblad, Bo Christer Bertilson, Eva Toth-Pal
Objectives: to explore potential users' opinions of a translated and culturally adapted Swedish version of the General Medical Council's MultiSource Feedback Questionnaires. Methods: In this qualitative study, we used content analysis on semi-structured interviews from 44 resident doctors, 29 medical colleagues and 28 patients to analyse their opinions of the Swedish adapted version, created through translation and expert review. Transcribed interview data concerning the informants' general thoughts about the tool were coded manually by three independent coders into categories, compiled as themes, and exemplified by citations...
June 15, 2018: International Journal of Medical Education
Michael Kossmeier, Georg Heinze
MAIN PROBLEM: Citations are widely used for measuring scientific impact. The goal of the present study is to predict citation counts of manuscripts submitted to Transplant International (TI) in the two calendar years following publication. METHODS: We considered a comprehensive set of 21 manuscript, author, and peer review related predictor variables available early in the peer review process. We also evaluated how successfully the peer-review process at TI identified and accepted the most promising manuscripts for publication...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Claire Anderson, Kevin Zhan, Matthew Boyd, Claire Mann
BACKGROUND: The review was carried out to inform the evaluation of the clinical pharmacists in general practice pilot scheme, a world leading initiative to improve health care delivery in England. Around 500 pharmacists are already working in general practice as part of the pilot, launched in July 2015. OBJECTIVES: The review attempts to explain the how pharmacists working in general practice is being implemented in the UK and beyond, what works well, what does not work so well and everything in-between...
June 12, 2018: Research in Social & Administrative Pharmacy: RSAP
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