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https://www.readbyqxmd.com/read/29683925/short-term-8-weeks-high-intensity-interval-training-in-diseased-cohorts
#1
James E M Blackwell, Brett Doleman, Philip J J Herrod, Samuel Ricketts, Bethan E Phillips, Jonathan N Lund, John P Williams
BACKGROUND & AIM: Exercise training regimes can lead to improvements in measures of cardiorespiratory fitness (CRF), improved general health, and reduced morbidity and overall mortality risk. High intensity interval training (HIIT) offers a time-efficient approach to improve CRF in healthy individuals, but the relative benefits of HIIT compared to traditional training methods are unknown in across different disease cohorts. METHODS: This systematic review and meta-analysis compares CRF gains in randomised controlled trials of short-term (<8 weeks) HIIT vs...
April 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29683475/pharmacological-interventions-for-the-prevention-of-insufficiency-fractures-and-avascular-necrosis-associated-with-pelvic-radiotherapy-in-adults
#2
REVIEW
Qurrat U van den Blink, Kate Garcez, Caroline C Henson, Susan E Davidson, Claire E Higham
BACKGROUND: Pelvic radiotherapy is a treatment delivered to an estimated 150,000 to 300,000 people annually across high-income countries. Fractures due to normal stresses on weakened bone due to radiotherapy are termed insufficiency fractures. Pelvic radiotherapy-related interruption of the blood supply to the hip is termed avascular necrosis and is another recognised complication. The reported incidences of insufficiency fractures are 2.7% to 89% and risk of developing avascular necrosis is 0...
April 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29680585/functional-and-cognitive-impairment-social-functioning-frailty-and-adverse-health-outcomes-in-older-patients-with-esophageal-cancer-a-systematic-review
#3
Floor J van Deudekom, Henk G Klop, Henk H Hartgrink, Jurjen J Boonstra, Irene M Lips, Marije Slingerland, Simon P Mooijaart
BACKGROUND: Older patients with esophageal cancer are at high risk of adverse health outcomes, but the association of geriatric assessment with adverse health outcomes in these patients has not been systematically evaluated. The aim of this systematic review was to study the association of functional and cognitive impairment, social environment and frailty with adverse health outcomes in patients diagnosed with esophageal cancer. METHODS: We searched Pubmed, Embase, Web of Science and Cochrane Library for original studies reporting on associations of functional or cognitive impairment, social environment and frailty with adverse outcomes (mortality, functional or cognitive decline, adverse events during treatment, prolonged length of hospitalization (LOS) and health related quality of life (HRQoL)) after follow-up in patients with esophageal cancer...
April 18, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29679367/a-systematic-review-of-the-quality-of-reporting-of-simulation-studies-about-methods-for-the-analysis-of-complex-longitudinal-patient-reported-outcomes-data
#4
REVIEW
Aynslie M Hinds, Tolulope T Sajobi, Véronique Sebille, Richard Sawatzky, Lisa M Lix
PURPOSE: This study describes the characteristics and quality of reporting for published computer simulation studies about statistical methods to analyze complex longitudinal (i.e., repeated measures) patient-reported outcomes (PROs); we included methods for longitudinal latent variable measurement and growth models and response shift. METHODS: Scopus, PsycINFO, PubMed, EMBASE, and Social Science Citation Index were searched for English-language studies published between 1999 and 2016 using selected keywords...
April 20, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29678965/parents-uptake-of-human-papillomavirus-vaccines-for-their-children-a-systematic-review-and-meta-analysis-of-observational-studies
#5
Peter A Newman, Carmen H Logie, Ashley Lacombe-Duncan, Philip Baiden, Suchon Tepjan, Clara Rubincam, Nick Doukas, Farid Asey
OBJECTIVE: To examine factors associated with parents' uptake of human papillomavirus (HPV) vaccines for their children. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Cochrane Library, AIDSLINE, CINAHL, EMBASE, PsycINFO, Social Sciences Abstracts, Ovid MEDLINE, Scholars Portal, Social Sciences Citation Index and Dissertation Abstracts International from inception through November 2017. METHODS: We included studies that sampled parents and assessed uptake of HPV vaccines for their children (≤18 years) and/or sociodemographics, knowledge, attitudes or other factors associated with uptake...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678454/top-100-cited-articles-on-radiation-exposure-in-medical-imaging-a-bibliometric-analysis
#6
Jason Kinnin, Tarek N Hanna, Marc Jutras, Babar Hasan, Rick Bhatia, Faisal Khosa
BACKGROUND: Bibliometric analyses by highest number of citations can help researchers and funding agencies in determining the most influential articles in a field. The main objective of this analysis was to identify the top 100 cited articles addressing radiation exposure from medical imaging and assess their characteristics. METHODS: Relevant articles were extracted from the Scopus database after a systematic search by researchers using an iteratively defined Boolean search string...
March 20, 2018: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/29678450/effects-of-exercise-training-on-pulmonary-function-in-adults-with-chronic-lung-disease-a-meta-analysis-of-randomized-controlled-trials
#7
REVIEW
Pablo A Salcedo, Jacob B Lindheimer, Jacquelyn C Klein-Adams, Anays M Sotolongo, Michael J Falvo
OBJECTIVE: To quantify the effect of exercise training on indices of pulmonary function in adults with chronic lung disease using meta-analytic techniques. Whole body exercise training is well-known to confer favorable adaptations to multiple organ systems; however, exercise-induced adaptations to the respiratory system are assumed to be limited, if present at all, but have not been systematically reviewed. DATA SOURCES: Eligible trials were identified using a systematic search of Medline, Web of Science, Physiotherapy Evidence Database (PEDro) and GoogleScholar databases...
April 17, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29674680/author-correction-transient-scute-activation-via-a-self-stimulatory-loop-directs-enteroendocrine-cell-pair-specification-from-self-renewing-intestinal-stem-cells
#8
Jun Chen, Na Xu, Chenhui Wang, Pin Huang, Huanwei Huang, Zhen Jin, Zhongsheng Yu, Tao Cai, Renjie Jiao, Rongwen Xi
In the version of this Article originally published, the author had misnumbered the reference citations in the Methods, using numbers 1-14 instead of 46-59. These errors have now been corrected in all online versions of the Article.
April 19, 2018: Nature Cell Biology
https://www.readbyqxmd.com/read/29673836/effects-of-lifestyle-modification-on-cancer-recurrence-overall-survival-and-quality-of-life-in-gynaecological-cancer-survivors-a-systematic-review-and-meta-analysis
#9
REVIEW
Ladan Yeganeh, Cheryce Harrison, Amanda J Vincent, Helena Teede, Jacqueline A Boyle
The benefits of lifestyle interventions for women who have survived gynaecological cancer (GC) remain unclear. This systematic review aimed to determine the effect of lifestyle interventions on cancer recurrence, overall survival and quality of life (QoL) in women with GC. We searched Medline, Embase, PsycINFO and EBM Reviews from June to July 2016 to identify relevant literature. We included randomized controlled trials in which a lifestyle intervention (diet, weight loss, physical activity and/or behavioural interventions) were compared with a control condition (usual care, placebo or other lifestyle interventions) in women who had survived endometrial or ovarian cancer...
May 2018: Maturitas
https://www.readbyqxmd.com/read/29673658/first-trimesters-pregnancy-associated-plasma-protein-a-levels-value-to-predict-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-the-literature
#10
REVIEW
Zahra Hadizadeh Talasaz, Ramin Sadeghi, Fariba Askari, Salmeh Dadgar, Atiyeh Vatanchi
Detecting pregnant women at risk of diabetes in first months can help them by early intervention for delaying or preventing onset of GDM. In this study, we aimed to assess the Predictive value of first trimester Pregnancy related plasma protein-A (PAPP-A) levels for detecting Gestational diabetes Mellitus (GDM). This systematic review and meta-analysis was conducted through probing in databases. PubMed, Scopus, Medline and Google scholar citations were searched to find the published papers from 1974 to 2017...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673548/for-better-or-worse-immune-system-involvement-in-alzheimer-s-disease
#11
EDITORIAL
Emma L Walton
In this issue of the Biomedical Journal, we explore the key role of the immune system in the development of Alzheimer's disease. We also learn more about the link between two disorders related to metabolic imbalances, with findings that could help to inform future screening programs. Finally, we would like to highlight some big news for our journal: the Biomedical Journal will be indexed in the Science Citation Index and receive its first official impact factor from this year.
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29672772/key-barriers-to-gout-care-a-systematic-review-and-thematic-synthesis-of-qualitative-studies
#12
Sharan K Rai, Hyon K Choi, Sally H J Choi, Anne F Townsend, Kam Shojania, Mary A De Vera
Objectives: Gout care remains highly suboptimal, contributing to an increased global disease burden. To understand barriers to gout care, our aim was to provide a systematic review and thematic synthesis of qualitative studies worldwide reporting provider and patient perspectives and experiences with management. Methods: We conducted a mapped search of MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, and Social Sciences Citation Index databases and selected qualitative studies of provider and patient perspectives on gout management...
April 17, 2018: Rheumatology
https://www.readbyqxmd.com/read/29672405/necrotizing-soft-tissue-infection-diagnostic-accuracy-of-physical-examination-imaging-and-lrinec-score-a-systematic-review-and-meta-analysis
#13
Shannon M Fernando, Alexandre Tran, Wei Cheng, Bram Rochwerg, Kwadwo Kyeremanteng, Andrew J E Seely, Kenji Inaba, Jeffrey J Perry
OBJECTIVE: We sought to summarize accuracy of physical examination, imaging, and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score in diagnosis of necrotizing soft tissue infection (NSTI) in adults with a soft tissue infection clinically concerning for NSTI. SUMMARY OF BACKGROUND DATA: NSTI is a life-threatening diagnosis. Delay to diagnosis and surgical management is associated with increased mortality. METHODS: We searched 6 databases from inception through November 2017...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29672201/effects-of-empathic-and-positive-communication-in-healthcare-consultations-a-systematic-review-and-meta-analysis
#14
Jeremy Howick, Andrew Moscrop, Alexander Mebius, Thomas R Fanshawe, George Lewith, Felicity L Bishop, Patriek Mistiaen, Nia W Roberts, Eglė Dieninytė, Xiao-Yang Hu, Paul Aveyard, Igho J Onakpoya
Background Practitioners who enhance how they express empathy and create positive expectations of benefit could improve patient outcomes. However, the evidence in this area has not been recently synthesised. Objective To estimate the effects of empathy and expectations interventions for any clinical condition. Design Systematic review and meta-analysis of randomised trials. Data sources Six databases from inception to August 2017. Study selection Randomised trials of empathy or expectations interventions in any clinical setting with patients aged 12 years or older...
January 1, 2018: Journal of the Royal Society of Medicine
https://www.readbyqxmd.com/read/29670517/computational-models-for-calcium-mediated-astrocyte-functions
#15
REVIEW
Tiina Manninen, Riikka Havela, Marja-Leena Linne
The computational neuroscience field has heavily concentrated on the modeling of neuronal functions, largely ignoring other brain cells, including one type of glial cell, the astrocytes. Despite the short history of modeling astrocytic functions, we were delighted about the hundreds of models developed so far to study the role of astrocytes, most often in calcium dynamics, synchronization, information transfer, and plasticity in vitro , but also in vascular events, hyperexcitability, and homeostasis. Our goal here is to present the state-of-the-art in computational modeling of astrocytes in order to facilitate better understanding of the functions and dynamics of astrocytes in the brain...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29670147/sciride-finder-a-citation-based-paradigm-in-biomedical-literature-search
#16
Adam Volanakis, Konrad Krawczyk
There are more than 26 million peer-reviewed biomedical research items according to Medline/PubMed. This breadth of information is indicative of the progress in biomedical sciences on one hand, but an overload for scientists performing literature searches on the other. A major portion of scientific literature search is to find statements, numbers and protocols that can be cited to build an evidence-based narrative for a new manuscript. Because science builds on prior knowledge, such information has likely been written out and cited in an older manuscript...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669703/physical-activity-sedentary-behavior-and-diet-related-ehealth-and-mhealth-research-bibliometric-analysis
#17
REVIEW
Andre Matthias Müller, Carol A Maher, Corneel Vandelanotte, Melanie Hingle, Anouk Middelweerd, Michael L Lopez, Ann DeSmet, Camille E Short, Nicole Nathan, Melinda J Hutchesson, Louise Poppe, Catherine B Woods, Susan L Williams, Petra A Wark
BACKGROUND: Electronic health (eHealth) and mobile health (mHealth) approaches to address low physical activity levels, sedentary behavior, and unhealthy diets have received significant research attention. However, attempts to systematically map the entirety of the research field are lacking. This gap can be filled with a bibliometric study, where publication-specific data such as citations, journals, authors, and keywords are used to provide a systematic overview of a specific field...
April 18, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29667842/the-role-of-pcsk9-inhibitors-in-the-treatment-of-hypercholesterolemia
#18
Roshni S Patel, Emily M Scopelliti, Oludamilola Olugbile
OBJECTIVE: To evaluate the efficacy, safety, and cost-effectiveness of proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors and describe its place in therapy for the treatment of hypercholesterolemia. DATA SOURCES: A search of MEDLINE, CINAHL, and Clinicaltrials.gov was performed from January 2012 to March 2018 to identify literature pertaining to PCSK9 inhibitors using pre-specified search terms. Additional references were identified from citations of the literature...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29666750/tweet-success-scientific-communication-correlates-with-increased-citations-in-ecology-and-conservation
#19
Clayton T Lamb, Sophie L Gilbert, Adam T Ford
Science communication is seen as critical for the disciplines of ecology and conservation, where research products are often used to shape policy and decision making. Scientists are increasing their online media communication, via social media and news. Such media engagement has been thought to influence or predict traditional metrics of scholarship, such as citation rates. Here, we measure the association between citation rates and the Altmetric Attention Score-an indicator of the amount and reach of the attention an article has received-along with other forms of bibliometric performance (year published, journal impact factor, and article type)...
2018: PeerJ
https://www.readbyqxmd.com/read/29666203/efficacy-and-safety-of-pulmonary-application-of-corticosteroids-in-preterm-infants-with-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#20
Mahin Delara, Bhupendrasinh F Chauhan, Mê-Linh Le, Ahmed M Abou-Setta, Ryan Zarychanski, Geert W 'tJong
BACKGROUND: Systemic corticosteroids as the frontline treatment of respiratory distress syndrome (RDS) in preterm infants are associated with adverse effects on growth and neurodevelopmental outcome, but the pulmonary administration of steroids may help prevent the development of bronchopulmonary dysplasia (BPD) without these side effects. OBJECTIVES: To evaluate the efficacy and safety of pulmonary application of corticosteroids in preterm infants with RDS. METHODS: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials...
April 17, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
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